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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AMFR-FTO (FusionGDB2 ID:HG267TG79068)

Fusion Gene Summary for AMFR-FTO

check button Fusion gene summary
Fusion gene informationFusion gene name: AMFR-FTO
Fusion gene ID: hg267tg79068
HgeneTgene
Gene symbol

AMFR

FTO

Gene ID

267

79068

Gene nameautocrine motility factor receptorFTO alpha-ketoglutarate dependent dioxygenase
SynonymsGP78|RNF45ALKBH9|BMIQ14|GDFD
Cytomap('AMFR')('FTO')

16q13

16q12.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase AMFRRING finger protein 45RING-type E3 ubiquitin transferase AMFRalpha-ketoglutarate-dependent dioxygenase FTOAlkB homolog 9U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTOU6 small nuclear RNA N(6)-methyladenosine-demethylase FTOfat mass and obesity associatedfat mass and obesity-associated protei
Modification date2020032720200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000290649, ENST00000564283, 
Fusion gene scores* DoF score7 X 5 X 5=17512 X 10 X 7=840
# samples 815
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/840*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AMFR [Title/Abstract] AND FTO [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAMFR(56401356)-FTO(53967897), # samples:1
Anticipated loss of major functional domain due to fusion event.AMFR-FTO seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AMFR-FTO seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AMFR-FTO seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AMFR-FTO seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAMFR

GO:0000209

protein polyubiquitination

17310145|19103148

HgeneAMFR

GO:0030433

ubiquitin-dependent ERAD pathway

11724934|17872946

HgeneAMFR

GO:0051865

protein autoubiquitination

24810856

HgeneAMFR

GO:0070936

protein K48-linked ubiquitination

12847084|24424410

TgeneFTO

GO:0006307

DNA dealkylation involved in DNA repair

18775698|20376003

TgeneFTO

GO:0035552

oxidative single-stranded DNA demethylation

18775698|20376003

TgeneFTO

GO:0035553

oxidative single-stranded RNA demethylation

18775698|22002720|25452335|26457839|28002401|30197295

TgeneFTO

GO:0042245

RNA repair

18775698

TgeneFTO

GO:0061157

mRNA destabilization

28002401|30197295

TgeneFTO

GO:0070989

oxidative demethylation

18775698

TgeneFTO

GO:0080111

DNA demethylation

18775698


check buttonFusion gene breakpoints across AMFR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FTO (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-WP-A9GB-01AAMFRchr16

56401356

-FTOchr16

53967897

+


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Fusion Gene ORF analysis for AMFR-FTO

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000290649ENST00000472835AMFRchr16

56401356

-FTOchr16

53967897

+
In-frameENST00000290649ENST00000394647AMFRchr16

56401356

-FTOchr16

53967897

+
In-frameENST00000290649ENST00000431610AMFRchr16

56401356

-FTOchr16

53967897

+
In-frameENST00000290649ENST00000460382AMFRchr16

56401356

-FTOchr16

53967897

+
In-frameENST00000290649ENST00000463855AMFRchr16

56401356

-FTOchr16

53967897

+
In-frameENST00000290649ENST00000471389AMFRchr16

56401356

-FTOchr16

53967897

+
intron-3CDSENST00000564283ENST00000394647AMFRchr16

56401356

-FTOchr16

53967897

+
intron-3CDSENST00000564283ENST00000431610AMFRchr16

56401356

-FTOchr16

53967897

+
intron-3CDSENST00000564283ENST00000460382AMFRchr16

56401356

-FTOchr16

53967897

+
intron-3CDSENST00000564283ENST00000463855AMFRchr16

56401356

-FTOchr16

53967897

+
intron-3CDSENST00000564283ENST00000471389AMFRchr16

56401356

-FTOchr16

53967897

+
intron-intronENST00000564283ENST00000472835AMFRchr16

56401356

-FTOchr16

53967897

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000290649AMFRchr1656401356-ENST00000471389FTOchr1653967897+1211518102112088625
ENST00000290649AMFRchr1656401356-ENST00000394647FTOchr1653967897+226118102112088625
ENST00000290649AMFRchr1656401356-ENST00000431610FTOchr1653967897+231218102112088625
ENST00000290649AMFRchr1656401356-ENST00000460382FTOchr1653967897+316118102112088625
ENST00000290649AMFRchr1656401356-ENST00000463855FTOchr1653967897+463718102112088625

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000290649ENST00000471389AMFRchr1656401356-FTOchr1653967897+0.0046803740.99531966
ENST00000290649ENST00000394647AMFRchr1656401356-FTOchr1653967897+0.0280000570.9719999
ENST00000290649ENST00000431610AMFRchr1656401356-FTOchr1653967897+0.0265611070.9734389
ENST00000290649ENST00000460382AMFRchr1656401356-FTOchr1653967897+0.0134273710.9865726
ENST00000290649ENST00000463855AMFRchr1656401356-FTOchr1653967897+0.0073849760.992615

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Fusion Genomic Features for AMFR-FTO


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AMFRchr1656401355-FTOchr1653967896+1.46E-060.99999857
AMFRchr1656401355-FTOchr1653967896+1.46E-060.99999857

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AMFR-FTO


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:56401356/chr16:53967897)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAMFRchr16:56401356chr16:53967897ENST00000290649-1214456_498533644.0DomainCUE
HgeneAMFRchr16:56401356chr16:53967897ENST00000290649-1214122_142533644.0TransmembraneHelical
HgeneAMFRchr16:56401356chr16:53967897ENST00000290649-1214145_165533644.0TransmembraneHelical
HgeneAMFRchr16:56401356chr16:53967897ENST00000290649-1214186_206533644.0TransmembraneHelical
HgeneAMFRchr16:56401356chr16:53967897ENST00000290649-1214215_235533644.0TransmembraneHelical
HgeneAMFRchr16:56401356chr16:53967897ENST00000290649-1214276_296533644.0TransmembraneHelical
HgeneAMFRchr16:56401356chr16:53967897ENST00000290649-1214429_449533644.0TransmembraneHelical
HgeneAMFRchr16:56401356chr16:53967897ENST00000290649-121482_102533644.0TransmembraneHelical
HgeneAMFRchr16:56401356chr16:53967897ENST00000290649-1214341_379533644.0Zinc fingerRING-type
TgeneFTOchr16:56401356chr16:53967897ENST0000043161025213_22414107.0RegionLoop L1%3B predicted to block binding of double-stranded DNA or RNA
TgeneFTOchr16:56401356chr16:53967897ENST0000043161025231_23414107.0RegionSubstrate binding
TgeneFTOchr16:56401356chr16:53967897ENST0000043161025316_31814107.0RegionAlpha-ketoglutarate binding
TgeneFTOchr16:56401356chr16:53967897ENST000004316102532_32714107.0RegionFe2OG dioxygenase domain
TgeneFTOchr16:56401356chr16:53967897ENST0000046038214213_22414107.0RegionLoop L1%3B predicted to block binding of double-stranded DNA or RNA
TgeneFTOchr16:56401356chr16:53967897ENST0000046038214231_23414107.0RegionSubstrate binding
TgeneFTOchr16:56401356chr16:53967897ENST0000046038214316_31814107.0RegionAlpha-ketoglutarate binding
TgeneFTOchr16:56401356chr16:53967897ENST000004603821432_32714107.0RegionFe2OG dioxygenase domain
TgeneFTOchr16:56401356chr16:53967897ENST0000046385503213_22435128.0RegionLoop L1%3B predicted to block binding of double-stranded DNA or RNA
TgeneFTOchr16:56401356chr16:53967897ENST0000046385503231_23435128.0RegionSubstrate binding
TgeneFTOchr16:56401356chr16:53967897ENST0000046385503316_31835128.0RegionAlpha-ketoglutarate binding
TgeneFTOchr16:56401356chr16:53967897ENST000004638550332_32735128.0RegionFe2OG dioxygenase domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAMFRchr16:56401356chr16:53967897ENST00000290649-1214622_640533644.0RegionVCP/p97-interacting motif (VIM)
TgeneFTOchr16:56401356chr16:53967897ENST0000047138969213_224413506.0RegionLoop L1%3B predicted to block binding of double-stranded DNA or RNA
TgeneFTOchr16:56401356chr16:53967897ENST0000047138969231_234413506.0RegionSubstrate binding
TgeneFTOchr16:56401356chr16:53967897ENST0000047138969316_318413506.0RegionAlpha-ketoglutarate binding
TgeneFTOchr16:56401356chr16:53967897ENST000004713896932_327413506.0RegionFe2OG dioxygenase domain


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Fusion Gene Sequence for AMFR-FTO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4215_4215_1_AMFR-FTO_AMFR_chr16_56401356_ENST00000290649_FTO_chr16_53967897_ENST00000394647_length(transcript)=2261nt_BP=1810nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGGCTCATCAGATTCAAGAGATGTTTCCCCA
GGTTCCATACCATCTGGTACTGCAGGACCTCCAGCTGACACGCTCAGTTGAAATAACAACAGACAATATTTTAGAAGGACGGATTCAAGT
ACCTTTTCCTACACAGCGGTCAGATAGCATCAGACCTGCATTGAACAGTCCTGTGGAAAGGCCAAGCAGTGACCAGGAAGAGGGAGAAAC
TTCTGCTCAGACAAATGCTGTGCTTCATGAAGTTAAAAGAGAGGGGCTCCCCGTGGAACAAAGGAATGAAATCTTGACTGCCATCCTTGC
CTCGCTCACTGCACGCCAGAACCTGAGGAGAGAATGGCATGCCAGGTGCCAGTCACGAATTGCCCGAACATTACCTGCTGATCAGAAGCC
AGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCACAGACATCGTTTCAGAACTCAGAGGTCAGCT
TCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGGCTTTTCTCCTCCAACGTTGTCATGGGCTTAA
GCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAAAACAGCTAGGAAATGGTGCCCATGAAGTTTT

>4215_4215_1_AMFR-FTO_AMFR_chr16_56401356_ENST00000290649_FTO_chr16_53967897_ENST00000394647_length(amino acids)=625AA_BP=533
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTNAVLHE

--------------------------------------------------------------
>4215_4215_2_AMFR-FTO_AMFR_chr16_56401356_ENST00000290649_FTO_chr16_53967897_ENST00000431610_length(transcript)=2312nt_BP=1810nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGGCTCATCAGATTCAAGAGATGTTTCCCCA
GGTTCCATACCATCTGGTACTGCAGGACCTCCAGCTGACACGCTCAGTTGAAATAACAACAGACAATATTTTAGAAGGACGGATTCAAGT
ACCTTTTCCTACACAGCGGTCAGATAGCATCAGACCTGCATTGAACAGTCCTGTGGAAAGGCCAAGCAGTGACCAGGAAGAGGGAGAAAC
TTCTGCTCAGACAAATGCTGTGCTTCATGAAGTTAAAAGAGAGGGGCTCCCCGTGGAACAAAGGAATGAAATCTTGACTGCCATCCTTGC
CTCGCTCACTGCACGCCAGAACCTGAGGAGAGAATGGCATGCCAGGTGCCAGTCACGAATTGCCCGAACATTACCTGCTGATCAGAAGCC
AGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCACAGACATCGTTTCAGAACTCAGAGGTCAGCT
TCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGGCTTTTCTCCTCCAACGTTGTCATGGGCTTAA
GCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAAAACAGCTAGGAAATGGTGCCCATGAAGTTTT

>4215_4215_2_AMFR-FTO_AMFR_chr16_56401356_ENST00000290649_FTO_chr16_53967897_ENST00000431610_length(amino acids)=625AA_BP=533
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTNAVLHE

--------------------------------------------------------------
>4215_4215_3_AMFR-FTO_AMFR_chr16_56401356_ENST00000290649_FTO_chr16_53967897_ENST00000460382_length(transcript)=3161nt_BP=1810nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGGCTCATCAGATTCAAGAGATGTTTCCCCA
GGTTCCATACCATCTGGTACTGCAGGACCTCCAGCTGACACGCTCAGTTGAAATAACAACAGACAATATTTTAGAAGGACGGATTCAAGT
ACCTTTTCCTACACAGCGGTCAGATAGCATCAGACCTGCATTGAACAGTCCTGTGGAAAGGCCAAGCAGTGACCAGGAAGAGGGAGAAAC
TTCTGCTCAGACAAATGCTGTGCTTCATGAAGTTAAAAGAGAGGGGCTCCCCGTGGAACAAAGGAATGAAATCTTGACTGCCATCCTTGC
CTCGCTCACTGCACGCCAGAACCTGAGGAGAGAATGGCATGCCAGGTGCCAGTCACGAATTGCCCGAACATTACCTGCTGATCAGAAGCC
AGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCACAGACATCGTTTCAGAACTCAGAGGTCAGCT
TCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGGCTTTTCTCCTCCAACGTTGTCATGGGCTTAA
GCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAAAACAGCTAGGAAATGGTGCCCATGAAGTTTT
AAATGTTTTAAAATGACCCTGTGTTATAGTCTGATTTGGTGTTAAACAGGACCTTCTTCCCCCAAAATTGTTCAGATTATAAAATGTGAG
CCATTCAGCCCCCAAGGTCCAGGGCAGGCGACAGGAACGAGCCCAGCGTGTGACAAAGCCTAACCTACTTTCCTCTTTCCCAAGCTTTTT
CAGAGACTCTGGAGTGGACCCAGCCCTCTGGGGAAAGACAGAACTTAGAGACATCCCAGTTACTCACCACACCCATAGTGCTGTCCAATA
TGGTAGCCACTAGCTAGCTGTGGCTACTTCAATTTAAATTCAGTTTTAATTTTAATTAAAAATGCAGCTCTTCAGTCGCCCTGGCCACAT
TTCAAGTGCTTAACAGCCTCATGTGGCTAGTGACTGCTGTATTGGACGGTACAGATATGGAACATTTTCATCATCGAAGAAAGTCCTATT
GGACAACACTTCTATAAAAAGTTTGAGAGCAGGAATTCTCATTTCCATTCGTCTGTAGCTTCTATCCCCAAAGGCAAAGAAACTAAAAGA
GAAATGACTCATTGAAGATTGGCCTCTTTCCTTTCTCTAAGACAAACCTAAGTAAAAGCCTGAGCTTTGAGTCCTATGCTCAGCACACGG
GAAGGAGATGTTAATAATTAAAATAAAGTTGATATCCTGTCTTTAGGGAGTTCCCTTGATCTCTTGAAAGAGACACAGCCCCATTTACAT
TATTTCGTGGATTTCACCAGCATAGTATAGTTTTTTTCTGTAAGTCCCTCATTCTTATGTAATAACAGGTGGAACTGAGGTTTGAAGAAC
CTCAGTGGCCCATCCTGATGACATTGGAGACTCAAAGAGACAAGAGAGAGTAGGGTTTAAAACCTGAGCTTTAAGACTCCCACTAGCTTC

>4215_4215_3_AMFR-FTO_AMFR_chr16_56401356_ENST00000290649_FTO_chr16_53967897_ENST00000460382_length(amino acids)=625AA_BP=533
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTNAVLHE

--------------------------------------------------------------
>4215_4215_4_AMFR-FTO_AMFR_chr16_56401356_ENST00000290649_FTO_chr16_53967897_ENST00000463855_length(transcript)=4637nt_BP=1810nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGGCTCATCAGATTCAAGAGATGTTTCCCCA
GGTTCCATACCATCTGGTACTGCAGGACCTCCAGCTGACACGCTCAGTTGAAATAACAACAGACAATATTTTAGAAGGACGGATTCAAGT
ACCTTTTCCTACACAGCGGTCAGATAGCATCAGACCTGCATTGAACAGTCCTGTGGAAAGGCCAAGCAGTGACCAGGAAGAGGGAGAAAC
TTCTGCTCAGACAAATGCTGTGCTTCATGAAGTTAAAAGAGAGGGGCTCCCCGTGGAACAAAGGAATGAAATCTTGACTGCCATCCTTGC
CTCGCTCACTGCACGCCAGAACCTGAGGAGAGAATGGCATGCCAGGTGCCAGTCACGAATTGCCCGAACATTACCTGCTGATCAGAAGCC
AGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCACAGACATCGTTTCAGAACTCAGAGGTCAGCT
TCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGGCTTTTCTCCTCCAACGTTGTCATGGGCTTAA
GCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAAAACAGCTAGGAAATGGTGCCCATGAAGTTTT
AAATGTTTTAAAATGACCCTGTGTTATAGTCTGATTTGGTGTTAAACAGGACCTTCTTCCCCCAAAATTGTTCAGATTATAAAATGTGAG
CCATTCAGCCCCCAAGGTCCAGGGCAGGCGACAGGAACGAGCCCAGCGTGTGACAAAGCCTAACCTACTTTCCTCTTTCCCAAGCTTTTT
CAGAGACTCTGGAGTGGACCCAGCCCTCTGGGGAAAGACAGAACTTAGAGACATCCCAGTTACTCACCACACCCATAGTGCTGTCCAATA
TGGTAGCCACTAGCTAGCTGTGGCTACTTCAATTTAAATTCAGTTTTAATTTTAATTAAAAATGCAGCTCTTCAGTCGCCCTGGCCACAT
TTCAAGTGCTTAACAGCCTCATGTGGCTAGTGACTGCTGTATTGGACGGTACAGATATGGAACATTTTCATCATCGAAGAAAGTCCTATT
GGACAACACTTCTATAAAAAGTTTGAGAGCAGGAATTCTCATTTCCATTCGTCTGTAGCTTCTATCCCCAAAGGCAAAGAAACTAAAAGA
GAAATGACTCATTGAAGATTGGCCTCTTTCCTTTCTCTAAGACAAACCTAAGTAAAAGCCTGAGCTTTGAGTCCTATGCTCAGCACACGG
GAAGGAGATGTTAATAATTAAAATAAAGTTGATATCCTGTCTTTAGGGAGTTCCCTTGATCTCTTGAAAGAGACACAGCCCCATTTACAT
TATTTCGTGGATTTCACCAGCATAGTATAGTTTTTTTCTGTAAGTCCCTCATTCTTATGTAATAACAGGTGGAACTGAGGTTTGAAGAAC
CTCAGTGGCCCATCCTGATGACATTGGAGACTCAAAGAGACAAGAGAGAGTAGGGTTTAAAACCTGAGCTTTAAGACTCCCACTAGCTTC
GTGTCCTTTGGCATGTTAACGTGCCTCAGTTTCCTCATCTGTATAATGGGGATATATGAAAGGCACCAGTCCTAAGGTGAACATTAAGTG
AGATGATTCTAGTTACAGACTTAGAACAATTTCCAGCACATAGTTAAATATCCAGGAAATTCTGGTACTGTTATGTGTGGGTGAGCTGAC
CTGGATGTAGATGTTTTCCTCTCTCTTGCTGACCCCTCCGCCAGTTTTGTCTTGTGATGCCATTAACACATCTCTCCCTTTCTGACCTGG
CTCCTGCCCATTGGTGTCCCAAGAAATCGTGAGAATAGTTAGCCCCCCGTCTCCCCAGCCTGTTGCTTTCTCGTGTAGTTGTTCACAGTA
GTTGAGAAGTTGAAGAGCTTTTGCCTATTGAAGGTGCACTGAGAATAAACTCTTTCCTGCCACCAGAATTGCAGTGGTTCACGGCCTGCA
CTCATTCCCATGAATGCAGTTAATAGCCACAGAAATGTCACATTAAGCAAAGCAGCCAGGGTCTCATCGTGTTGAGACTCGAGTCTCTCA
GACCTTGGATTCATTCCCTGGTGTCTTTGAGCCTCAGTTTCCTCATTGGTAAAAGAGAAGTGAAGCAGTGTCTCACAGGGTCATTACAGA
GATTAAATGAAATAAATGAAATAACATAGACCAGGAGGGCGTGGTGTTTAAAAGTCACAGATGGGGCACCCTCGGGCCATCCAGCCCAGT
GTTTTCTTTAGCCCCTATGATGTTCATTTTTTGTTATATCCCATTAGGTGCCCATATTTAAAAATTGGGAGATTTCACATAAAATTAAAA
GGTCTGCATTTTCTTTTTTCTTTTCTTTTTTTTTTTTTTTGAGACACAGTCTCACTCTGTCACCAGGCTAGAGTGCAGTGGCACGATCTC
AGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACGTGCCACCACGC
CCAGCTAATTTTTGTATTTTTAGCAGAGATGGGGTTTCACCACATTGGCCAGGATGGTCTCGATCTCAACCTCGTGATCCACCCACCTCG
GTCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCGCGCCAAGCCAAGGTCTGCATTTTTCTTTAGAACTCAGAACACCCAATAGTCC
TAGGCCCCCATCCTCGCATGGCAGCAAGCTAAATAAGCATCTTCCCACTGCGAGTTGGGGCATGACCCAGCCTATGGTTTGCCATACTCC
CTCTTTTTCTCCGTTTTTTCATTAATTGTGAACCTGACCTGCATCACCCTTTCATGTCAGTGCTCTCCAAACCTGCTTGCTTGCACCCCT
CTAGTCGAAATATTTTGTGCTTACCCCAATATATGTGTGTGACTATTGAACTCTATTCGTAGACTGCTTGTACTAATGTCATTTGCATCA

>4215_4215_4_AMFR-FTO_AMFR_chr16_56401356_ENST00000290649_FTO_chr16_53967897_ENST00000463855_length(amino acids)=625AA_BP=533
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTNAVLHE

--------------------------------------------------------------
>4215_4215_5_AMFR-FTO_AMFR_chr16_56401356_ENST00000290649_FTO_chr16_53967897_ENST00000471389_length(transcript)=12115nt_BP=1810nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGGCTCATCAGATTCAAGAGATGTTTCCCCA
GGTTCCATACCATCTGGTACTGCAGGACCTCCAGCTGACACGCTCAGTTGAAATAACAACAGACAATATTTTAGAAGGACGGATTCAAGT
ACCTTTTCCTACACAGCGGTCAGATAGCATCAGACCTGCATTGAACAGTCCTGTGGAAAGGCCAAGCAGTGACCAGGAAGAGGGAGAAAC
TTCTGCTCAGACAAATGCTGTGCTTCATGAAGTTAAAAGAGAGGGGCTCCCCGTGGAACAAAGGAATGAAATCTTGACTGCCATCCTTGC
CTCGCTCACTGCACGCCAGAACCTGAGGAGAGAATGGCATGCCAGGTGCCAGTCACGAATTGCCCGAACATTACCTGCTGATCAGAAGCC
AGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCACAGACATCGTTTCAGAACTCAGAGGTCAGCT
TCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGGCTTTTCTCCTCCAACGTTGTCATGGGCTTAA
GCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAAAACAGCTAGGAAATGGTGCCCATGAAGTTTT
AAATGTTTTAAAATGACCCTGTGTTATAGTCTGATTTGGTGTTAAACAGGACCTTCTTCCCCCAAAATTGTTCAGATTATAAAATGTGAG
CCATTCAGCCCCCAAGGTCCAGGGCAGGCGACAGGAACGAGCCCAGCGTGTGACAAAGCCTAACCTACTTTCCTCTTTCCCAAGCTTTTT
CAGAGACTCTGGAGTGGACCCAGCCCTCTGGGGAAAGACAGAACTTAGAGACATCCCAGTTACTCACCACACCCATAGTGCTGTCCAATA
TGGTAGCCACTAGCTAGCTGTGGCTACTTCAATTTAAATTCAGTTTTAATTTTAATTAAAAATGCAGCTCTTCAGTCGCCCTGGCCACAT
TTCAAGTGCTTAACAGCCTCATGTGGCTAGTGACTGCTGTATTGGACGGTACAGATATGGAACATTTTCATCATCGAAGAAAGTCCTATT
GGACAACACTTCTATAAAAAGTTTGAGAGCAGGAATTCTCATTTCCATTCGTCTGTAGCTTCTATCCCCAAAGGCAAAGAAACTAAAAGA
GAAATGACTCATTGAAGATTGGCCTCTTTCCTTTCTCTAAGACAAACCTAAGTAAAAGCCTGAGCTTTGAGTCCTATGCTCAGCACACGG
GAAGGAGATGTTAATAATTAAAATAAAGTTGATATCCTGTCTTTAGGGAGTTCCCTTGATCTCTTGAAAGAGACACAGCCCCATTTACAT
TATTTCGTGGATTTCACCAGCATAGTATAGTTTTTTTCTGTAAGTCCCTCATTCTTATGTAATAACAGGTGGAACTGAGGTTTGAAGAAC
CTCAGTGGCCCATCCTGATGACATTGGAGACTCAAAGAGACAAGAGAGAGTAGGGTTTAAAACCTGAGCTTTAAGACTCCCACTAGCTTC
GTGTCCTTTGGCATGTTAACGTGCCTCAGTTTCCTCATCTGTATAATGGGGATATATGAAAGGCACCAGTCCTAAGGTGAACATTAAGTG
AGATGATTCTAGTTACAGACTTAGAACAATTTCCAGCACATAGTTAAATATCCAGGAAATTCTGGTACTGTTATGTGTGGGTGAGCTGAC
CTGGATGTAGATGTTTTCCTCTCTCTTGCTGACCCCTCCGCCAGTTTTGTCTTGTGATGCCATTAACACATCTCTCCCTTTCTGACCTGG
CTCCTGCCCATTGGTGTCCCAAGAAATCGTGAGAATAGTTAGCCCCCCGTCTCCCCAGCCTGTTGCTTTCTCGTGTAGTTGTTCACAGTA
GTTGAGAAGTTGAAGAGCTTTTGCCTATTGAAGGTGCACTGAGAATAAACTCTTTCCTGCCACCAGAATTGCAGTGGTTCACGGCCTGCA
CTCATTCCCATGAATGCAGTTAATAGCCACAGAAATGTCACATTAAGCAAAGCAGCCAGGGTCTCATCGTGTTGAGACTCGAGTCTCTCA
GACCTTGGATTCATTCCCTGGTGTCTTTGAGCCTCAGTTTCCTCATTGGTAAAAGAGAAGTGAAGCAGTGTCTCACAGGGTCATTACAGA
GATTAAATGAAATAAATGAAATAACATAGACCAGGAGGGCGTGGTGTTTAAAAGTCACAGATGGGGCACCCTCGGGCCATCCAGCCCAGT
GTTTTCTTTAGCCCCTATGATGTTCATTTTTTGTTATATCCCATTAGGTGCCCATATTTAAAAATTGGGAGATTTCACATAAAATTAAAA
GGTCTGCATTTTCTTTTTTCTTTTCTTTTTTTTTTTTTTTGAGACACAGTCTCACTCTGTCACCAGGCTAGAGTGCAGTGGCACGATCTC
AGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACGTGCCACCACGC
CCAGCTAATTTTTGTATTTTTAGCAGAGATGGGGTTTCACCACATTGGCCAGGATGGTCTCGATCTCAACCTCGTGATCCACCCACCTCG
GTCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCGCGCCAAGCCAAGGTCTGCATTTTTCTTTAGAACTCAGAACACCCAATAGTCC
TAGGCCCCCATCCTCGCATGGCAGCAAGCTAAATAAGCATCTTCCCACTGCGAGTTGGGGCATGACCCAGCCTATGGTTTGCCATACTCC
CTCTTTTTCTCCGTTTTTTCATTAATTGTGAACCTGACCTGCATCACCCTTTCATGTCAGTGCTCTCCAAACCTGCTTGCTTGCACCCCT
CTAGTCGAAATATTTTGTGCTTACCCCAATATATGTGTGTGACTATTGAACTCTATTCGTAGACTGCTTGTACTAATGTCATTTGCATCA
TAAAATATTCATATCCAATAAACATATTAAAAGGATGAGATAAGAAACCGAGAGATTTTGCTGTTTTTTTCCTTTTGCATGGATGAGCCA
GCTTCACTGTCCTGGGTGGGGCCCAGGTGGAATTAGTTCTCAAAGTCCTCCAGGTGGAGTCAGGGAATGTGCAACAGGGTTGGAGAAATC
ACTACTTTAAGTGAATCCGAAAGGTGAGATCACATTTGCTCTAAAGAAATGGTGATCCCAGCACTTTGGGAGGCTGAGGCAGCAGATCAC
TGGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACACGGTGAAACCCCGTCTCTACTGAAAACACAAAAATTAGCTGGGTGTGGTGGTGTG
TGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGCAAATCGCTTGGCCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCATGCCACT
GCACTCCAGCCTGGGCCACGGAGCGAGAGAAGAAAGAAATGGTGACTTTCATTGATCATGTGTTTGAGGATTTCATGTGCTCTCCAGGGA
GGTTTCAGGTGGGTAGAAGGAGGTGGGCAAGACCCAATAAAAAAGCAGCTGGTGCGGGCAATGACAATGAACTCGTATCCTGCAGGGTCA
AAGGAAGGCTTGCTTCTGCTGTGAATTGGAGAAGGACTTTCCTGGAAGCACAGGCCCAGAAATCGCACCCTTCTCCCCATGTGTGCGGAT
AAGGGACCACTTCCATCAGCAGCAGCCCCCTCCTGCTTTCCTGCCAGTCCTCCCTGTGGTCCCAGGTCTCTTGAGAAAAGTGATCTAAGA
GATCCCTTTGCAATGAGGTGCTACTGACTGCCCTACCTCCCTCCCTTCCTCCCATGAATGTTTCTTGGTGCTGACCACAGCCTCAGCAAT
GAGGCAAGCCTGGGGACCCAAGACAGATCTCTGCCTCCCAGGCTAGTGGATGCCCTGGGATATGTAGTCACCAAAATAGGAACTTACCCC
ATAGTGGGGAAATAGACAGTAAGCAGCAAATCAATAACAAGAGTGTTCCAGATGGTTGTAAGTGCCAGGAAGGGAACCAACTGGGAGAGG
GACAAGAGGAGATGGTGACTGACCAAGGGGACCTTGATCAGGCTGTGGGGAAGGGAGGTGGTTGGGAAGAGCTTCCCAGGAAAGGGGACG
GCGGGCCCAGGCAGGAGAGCCTTGGGAGGGGGTGCCCAAGGAAGGAAAAGGGCCCTGAGCCTGAAGCCGAGAAGACCAGGAGGGGAGAAG
GGGAGATGTAGGGCAGAGCAGACGGGAGCCGCTCGGGTTTTATTCCACACACCCCAGGAAGCATGAGAGGGTTTCAAGCAGCAAGGGCAT
GGAAGTAACTTGGTGAGATATTTTTATGCATTAGATCATCGCTCTATCTGGATTCCAGAGGGTCTCTGAGAGAGCAAACAGCTTAATCCA
AAGGAGCGGCTTTCCAACTGGGAATGTCCCCCTGGCTGGGTGAGATCTCAAGATGGCCTGCGGCCCCTCTAGATTGCCTGCCTACAGAGT
TCACTCTAAACAGCCCCTCCCCTCCACACCCCAGCAGATCCATTCCTGACGCCCTCACTGGCAGGCTCCAGCCCCACAGAGCTTTCTAGA
CATAAAAGAGCAGGGTCATGGCATCATTGGTGACACAATTTTAGTAATAAGCTTCAAAACCCATCACTCCACTGAATCCAGGGATGCCAG
AATTGAGAGTCCATAGGACCCGTTTAACGGATCCCACATTCAGTAGACGGTTTTTTGTATGCTTCGAGGGAAGGAAGGTATTTTCAAATG
CAACTTCTTTTTTTTTTTTCTTGCTCTAGTTAGGGCTGATTTTACCACTGGGCAAATTGCATACATTTGGATCCATGCCACGCTAAAAAC
TGTTTATTTTGGAGATCTGTCAGAGGCAAGCACATGGAAGACAAGGGGATTCTGGTTTGAAAAGGCAATTCTCATCCAGACAGATTCAGA
TGGAGAGGAGCGGTGTGGATTAAAATGCGCCGAAGTGGTAATGCCGTTTATCCCGTTTGCCTTTGTTACTCTGTGATTAAATGGTATTTT
TAATTAAGTTTCATTGGGAGCCATAGGTATCGCGGTGGTGAAATCAATTTGACAACCATAAAGGGGAGAGACGGCACAGGCGTGTTGTGA
TGATTGCGGCTGTAGGGAAAGCCGGGCAGCTTGCAGAGGATGGGTGGGAGGAGGGGAAGCCGGCTAAGAATGACTTCCTGCAAGACAGCA
AGGGCACCCCTGGGCCACTGCTGTGTTTGGGAGGCAGGTTTTGGGGGTTGTCAGAAGGCATTCACCTGGTTCTCTCGCTCACCTGAGACA
CCCGATAGATTCCTGGAAACTCCAGGAAAGTATCTGAAGATCTGGTTCTCCATTCTCTCTTATTAACAAGGAGAACCACAAGTGCCCCCC
AGATCCCGGCTAGAAGGACCAGACAGCTTTCCACCCCGGTTCCCAGGCAGCCCTGCTCCCATAGTCCTGTGTCCCATCGGCCCCATGCTC
CCAGGACAGTCCTAATTCCCACCTCTCAGAACCTTGTCAGCCAAGTTCTTCCTGCTCTCTGGCCCAAATCCTCCTCCTACATTGGAAACT
GAGCCTCTCTGCATCCTCTGCTCTTTCTATCCCGCTGTCATTCATCAGATTTTCCAAATCTTTGGATTCCTGAGTGGCAGAAGAGGTTTT
CTGAGTTTAAGTTCTGATTCTGTGTGTGATTCTCACTCTACCACCTCTTCAAACCTTTGTTGTCTTATCTACAAAATAGAATAGTAGTAA
TCCATCACCTAAGGTTGTTGTGAAGGTTCAATAAGTTAATGCGTATTTAAAATGCCTCCCACAGTACCTGACATATACTGGGCTTCAGTG
AGGTACTAGCTATTATTATTAACCAAGTTTCCTGTGGTAACAGTTGTAGCTTTGTGACTGGGCCAAATCACTTAACCCCTCTGCGCTCCA
GTCTTTGTTTCTATAATGGGGATGATGATAATGCCTAGCTCATTGGATTGTTCTGTCCCCTACGATCAGCCATGTTAAGTGATTCATATC
ATGTCTGGTACTTAAAAATCACGCCACGCATGTACATTATTATGATGAAAAATATGATCCGTGATATCCTGACCAAAATATTAAAGGGAC
TAAAGATAGCTGTGGCTTGTTCAAGAAGAATATTGTGTCACTATCCCATATATTATCCCATTTGCTCTTCACAGCTTCCATTTTTCGCTA
GGCGGATGGCATGGAACTTTTTATAAATGAGATATTATGAAAAATGATGTTTTAGGACTCTCATTTCTACAGTGGGAGTAGGTCACCCAT
TGCAATTTTGGATTTGCTTAAAAAAATTCTTGCCATCACCTTCTAATGGATGATCTGTGTACAACAATTGTTTATTGACTCTGAATGTCT
AAGTACCAGGGTCAGTCTATTTCAAGGGGAGGGAAGCATTAATTAACCTCCAGCATTAGATTCAGTGATTCTTTTCCAATGATGCAGTTC
ATGACTTTGCTCGCATTTACTTTTCATCAATCCTGAAAGAATTGAGGTAAAATAGTTCCTCTGCACATGTGTGTCAAGCTAAATGGATAA
CAGCAGATACAGATCTGTTTGCCTGTCTGCACTTGCCTTTAGACAAAATTCATCAATTTTACAAAAGCCACTGACTAAACATGGCACCAA
TACAAATGAAGCACTTCTAGCAGGCGGAGATTCCCTTTGTTTCTGATCTGGTAAATGCGGTAGTTTCCTGCTGAGAGATGGGAAGTGCTG
GCCTAGGACAGCAAGGTGCCCTACAGGTGGGGCCAAAAGGGTCAAGACCGTTCTACAGGAAGTTTAGGAGAAGTTCAATGGTTCCAGATC
CTGTGTGCTTCGGGTAATTCTGACCCTCTTCATTAGTGATAATGGCATGAAGCTCTTTCACACAGTCTTTTTTTTTTTTCTTTTTTTTTT
TCAGACAGGGTCTCACCCTGTCACGTAGGCTGGAGTGCAGTGGTGAGATCACGGCTCACTGCAGCCTCGACTTCATGGGCTCAAGCGATT
CTCCTGCCTCAGCCTCCTAAGTAGTCGGGATCATAGGCACTTGCCACCACATCCGGCTAATTTTTTTGTAGAGACAGGATTTCACCACAT
TACACAGGCTGGTTTCAAACTCCGAGGCTCAAGTGATCTGCCTGCATCGGCCTCCCAAAGCGCTGAGATTACAAGCGTGAGCCACTACGC
CTTGCCCTCCACACAGCCTTGCTTGGTGTTAAAGATTAAACAAAGACCACAGGTGATCACTGTCTTCGTGGTGCCAGTTTCAAGGGCACC
CTTCTTCCCTTCCCAGCCTCCGAGAGAAGGAGAGAGGGTCCACAAGCCAGATCCATCCCCATCCACACAGGTAAAACCACGACTGTGCAG
CTAGCAGGTGGAGATAACATTTGGAAAAAGGCTTTGTAAATGCTAAAGTCCTACTCAAGTCCAAGGGAGAGAAATTATTATTATTCGTTT
TGTGAAACCAATTTAGTTTGGCTGGGTAATGGAAGAATTTCTACATACATTCATTACTTCTGATCAGGCAAGACCAGTCTGACACAGGAA
CAGTCTATGGCTCACTCTTAAAGCCACAGCAGGCTGCCAGGGCTTGGAGAAATAGAAACCTCTCTTGCACAAGAATAGTCTCAATGAATC
ATGTTAAGGCCTCTTTAGGTTTTTCAGACTCCATGCACCCTGTGGAAACTGCCTTTCTTGAGTAGAGGTACGTTCAGCACTTCATAAAAT
AATCTTGGAGCCTCCAGACACACGGATGGAGGAGCATGATTTCATTTGTTTCTTTGCAAAACTGCTGTCCCCAACTGAAAAACCTGATTA
TCCTTTCAAATAGGGAATTCGGCTTTCCACGTTGGAACCAGAACAGTTAACCTTCAAACCCCCAAGGCTTGCAAGAGATGAATCAGTTTC
TCAGACAGCCAAAGCCGTGGCTTATAACTCATCCAACCCAGAAAACTGGACCGCTGGTCACCTTCCTTCCCCCTGCCCCCAACTCTGCAG
ACAGAGGTTTCCCGTTGATTATGCCTTGATTAGAGTCAGGAGAGAAGCAAACCAGGTATATAGGATTCCATTATCCTTCCCTCCTCTGCT
CCCAACCAGGGTCACGCTGAGAGGGATCTCGGTGAACATGTGAACAATCAAGCCATGTTTACCATGGACGTTTAGTTTTCTTTTCTCAAA
ATCAAAACAGAGTTTAGTAGGCAGCGTATTTCATACATGCCCCTTGATCAATGGAATGATCTGTCAGAAGCCATTAAAGCCCCCATTAGC
TTGAATGCATTCAAAGCTAAACTATTGGATCATTTAAGGGCTGCAGTGATTGTTTTTAATATACCGTACATTGATTTCTCCCTGTGAGCA
GCAACATAAGTTTGAAACTAACTGTGTATGACTAAGGCTCCATTTGCTGTCTCCAACCCTCTGTGAGAAGCATGGTTTCACTTCGACCAG
AAATGTCTGTGTATAGTTTTCAAAGAGATGCAGACCCTGTTCGATTTCCCAAGATTTAGACTGGGTCGGGTTGTTATTTCTTTTTTCCCT
GAGCTTTCTCCCATTTCTTTGTGCCCATTAAGTGAGCTGTGCGTGCAGAATGGGAGAGGCATCCCTGCCAAGGACTTCAAGTGAAAGGCG
GTGGGAGAAATTGTTCTGAAAGCATGAAGCCCAGCTGAGGCCAAAATCAAAGTGAATTTGACAGCCTTGGGCCAGCAAAACTCTGTACCC
AGCAGAAAACAATAGATGTGTGGCTGTGTCAGGGGCATCCTCACTGGGACATAGCTTGGGGAGCTGAAGGTACCTTGGAAGGGCCAGATG
AGGAAGCTAGCCAAGGCCACAGGCCTTCCTTTGACTGCCATATTGCCAGCTCTTCATAGTATTGACTCTTCAGTCTTAGCCAACACACAC
TTGTTGATTCCTTCCGGAATGTCAGACTCTGCTAGCAACACAAGGTCCCTGTCCTCAAAATCCTATTCTTAATCAGCATTTCTAATTTCT
GCCCTTTGCTCATTTTAATACAGAGCCTGAGGATAGGAGAGCAGCGTGGTGAAAGAAGCAATAGTTACCACATTTGCAAAGGCACATACC
CCAAAGAGAAGTTTTTAATATGTCACACCCATATTTTATAGATGGGGCAATGGAAGTCCAGATGGGAGAAGTTATTTCAGGTGAATTATA
GAAACTGGATTTCAAGTTTCTGATAAGTATTGAATTTGGGAAGGCTGTGAACATTCTTGAGCCCCCCTCCCAAGTTCACCTTCAACATCC
TAAAGCAGGTTGAAGAGGAAGATGGTTCCAGGTCACTTACAAGAACAGGAACAGCCCCTCCCTCCAAATTTGAGCCCAGAAAGGAGAACC
TTTGTTACTCTAGAAAACAGTGTGTGTGCTATTGTTTTCTCCATAGGTCACAAACATCCACAAGATATTGGTGATTTTACATATTATTAG
AGCCACTGAAATTTATGATGCAGGATATTAACGTCAAAGAGGCCAAGATGCATCATTCAGAACACTGGCAGGTCAAGCAGAAACCACCGT
AGTAAAATTGAAAGCTGGAGTCAGCAAAGTATAGCCCACAGCCAAATCTGGCCCATCCCCTGTTCTTATAAAGTTTTATTGGAACGCAGC
CATGCTCATCGGTTTATGTATTATCTATGGCTGTTTCCAACTACAGTGGCAGAGCTGAATAGTTGCAAAGGACCATAGGGCTATCAAAGC
CCCAAATAGTCATTGTCTGACCCTTCATAGAAAAATTTTGCTGAACTGTAGTCTAGCTCCAAGGATTGTTGTATCACCTGTGATCGTGCC
TATTAAGCAATTAACGTCATGTCTAGTACTTAGTAATGACTCAGCATGTATCAATTACGATGATAAATATTATCATGGCATCCAAACCAA
AATACTCATGCCAACATCTCTCTGTACAGAAACATGGAAAAAGAGCGATGCTATTAAGGAGGAAAATGGAGCCAGGAGCAAAACCTAAGG
CTATTTCTGAACTAAAGAGGCCTGAATAAGGTAGTGAAAGGACCAGGGAAAGCCTTCCCACGGGGATGGAGAGCCACCTCCTCCCCGGCT
TTCTGGTTCAGATGTCTTGTCTCAACAGACGGCAGATTCGCAGGGAAGCAGGCCGAGCCTGATCTTTTCTCCGCTAGAACTGCTCAACAG
GTGAAGAATCTTTTTCCAGCACTCCTGAGCCCTTCGGGTCGCGGAACAGTGCGAAGATTATTCCAATGCCTCATTCGGAGAGGTGATAAT
CTGGTCTGTGGTTTCTTTTTCGGTGGGGCATGGGGTGGGGGTGAGTGTCATGCTTTCTAAGGCACAGGGCTGACTAAAGGGTGTCCTATT
TATAAGTCAGTAAAACACAGCGGCTTCATACTCTGTGCTTATTACCCAGAAGCCCCGGCTCTTAGAGTTTCTATTAAGATGTACCTCATA

>4215_4215_5_AMFR-FTO_AMFR_chr16_56401356_ENST00000290649_FTO_chr16_53967897_ENST00000471389_length(amino acids)=625AA_BP=533
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTNAVLHE

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Fusion Gene PPI Analysis for AMFR-FTO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AMFR-FTO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AMFR-FTO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAMFRC0002395Alzheimer's Disease1CTD_human
HgeneAMFRC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneAMFRC0005695Bladder Neoplasm1CTD_human
HgeneAMFRC0011265Presenile dementia1CTD_human
HgeneAMFRC0235874Disease Exacerbation1CTD_human
HgeneAMFRC0276496Familial Alzheimer Disease (FAD)1CTD_human
HgeneAMFRC0494463Alzheimer Disease, Late Onset1CTD_human
HgeneAMFRC0546126Acute Confusional Senile Dementia1CTD_human
HgeneAMFRC0750900Alzheimer's Disease, Focal Onset1CTD_human
HgeneAMFRC0750901Alzheimer Disease, Early Onset1CTD_human
TgeneC0028754Obesity6CTD_human
TgeneC2752001Growth Retardation, Developmental Delay, Coarse Facies, And Early Death4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0001973Alcoholic Intoxication, Chronic3PSYGENET
TgeneC0011581Depressive disorder3PSYGENET
TgeneC0005910Body Weight2CTD_human
TgeneC0011570Mental Depression2PSYGENET
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneC0025202melanoma1CTD_human
TgeneC0043094Weight Gain1CTD_human
TgeneC0525045Mood Disorders1PSYGENET
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC2362324Pediatric Obesity1CTD_human
TgeneC4317171Adolescent Obesity1CTD_human
TgeneC4521075Childhood Overweight1CTD_human
TgeneC4553478Infantile Obesity1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human
TgeneC4704955Infant Overweight1CTD_human
TgeneC4704956Adolescent Overweight1CTD_human