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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:AKAP8L-EPS15L1 (FusionGDB2 ID:HG26993TG58513)

Fusion Gene Summary for AKAP8L-EPS15L1

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP8L-EPS15L1
Fusion gene ID: hg26993tg58513
HgeneTgene
Gene symbol

AKAP8L

EPS15L1

Gene ID

26993

58513

Gene nameA-kinase anchoring protein 8 likeepidermal growth factor receptor pathway substrate 15 like 1
SynonymsHA95|HAP95|NAKAP|NAKAP95EPS15R
Cytomap('AKAP8L')('EPS15L1')

19p13.12

19p13.11

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 8-likeA kinase (PRKA) anchor protein 8-likeAKAP8-like proteinhelicase A-binding protein 95 kDahomologous to AKAP95 proteinneighbor of A-kinase anchoring protein 95neighbor of AKAP95testis tissue sperm-binding protein Li 90mPepidermal growth factor receptor substrate 15-like 1epidermal growth factor receptor substrate EPS15Reps15-related protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000397410, ENST00000595465, 
ENST00000595879, 
Fusion gene scores* DoF score9 X 10 X 6=54012 X 10 X 6=720
# samples 1313
** MAII scorelog2(13/540*10)=-2.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP8L [Title/Abstract] AND EPS15L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKAP8L(15529722)-EPS15L1(16532287), # samples:1
Anticipated loss of major functional domain due to fusion event.AKAP8L-EPS15L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP8L-EPS15L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP8L-EPS15L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP8L-EPS15L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKAP8L

GO:0006397

mRNA processing

17594903

HgeneAKAP8L

GO:0010793

regulation of mRNA export from nucleus

11402034

HgeneAKAP8L

GO:0045944

positive regulation of transcription by RNA polymerase II

11884601


check buttonFusion gene breakpoints across AKAP8L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across EPS15L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1L2-01AAKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-


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Fusion Gene ORF analysis for AKAP8L-EPS15L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000397410ENST00000248070AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
In-frameENST00000397410ENST00000455140AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
In-frameENST00000397410ENST00000535753AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
In-frameENST00000397410ENST00000594975AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
In-frameENST00000397410ENST00000597937AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
In-frameENST00000397410ENST00000602009AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
In-frameENST00000595465ENST00000248070AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
In-frameENST00000595465ENST00000455140AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
In-frameENST00000595465ENST00000535753AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
In-frameENST00000595465ENST00000594975AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
In-frameENST00000595465ENST00000597937AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
In-frameENST00000595465ENST00000602009AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
intron-3CDSENST00000595879ENST00000248070AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
intron-3CDSENST00000595879ENST00000455140AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
intron-3CDSENST00000595879ENST00000535753AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
intron-3CDSENST00000595879ENST00000594975AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
intron-3CDSENST00000595879ENST00000597937AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-
intron-3CDSENST00000595879ENST00000602009AKAP8Lchr19

15529722

-EPS15L1chr19

16532287

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397410AKAP8Lchr1915529722-ENST00000455140EPS15L1chr1916532287-25511441802084634
ENST00000397410AKAP8Lchr1915529722-ENST00000248070EPS15L1chr1916532287-21361441801946588
ENST00000397410AKAP8Lchr1915529722-ENST00000535753EPS15L1chr1916532287-19871441801616478
ENST00000397410AKAP8Lchr1915529722-ENST00000594975EPS15L1chr1916532287-17011441801622480
ENST00000397410AKAP8Lchr1915529722-ENST00000602009EPS15L1chr1916532287-28331441801157325
ENST00000397410AKAP8Lchr1915529722-ENST00000597937EPS15L1chr1916532287-28331441801157325
ENST00000595465AKAP8Lchr1915529722-ENST00000455140EPS15L1chr1916532287-25231161522056634
ENST00000595465AKAP8Lchr1915529722-ENST00000248070EPS15L1chr1916532287-21081161521918588
ENST00000595465AKAP8Lchr1915529722-ENST00000535753EPS15L1chr1916532287-19591161521588478
ENST00000595465AKAP8Lchr1915529722-ENST00000594975EPS15L1chr1916532287-16731161521594480
ENST00000595465AKAP8Lchr1915529722-ENST00000602009EPS15L1chr1916532287-28051161521129325
ENST00000595465AKAP8Lchr1915529722-ENST00000597937EPS15L1chr1916532287-28051161521129325

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397410ENST00000455140AKAP8Lchr1915529722-EPS15L1chr1916532287-0.0096048070.99039525
ENST00000397410ENST00000248070AKAP8Lchr1915529722-EPS15L1chr1916532287-0.0071667540.99283326
ENST00000397410ENST00000535753AKAP8Lchr1915529722-EPS15L1chr1916532287-0.0047739080.995226
ENST00000397410ENST00000594975AKAP8Lchr1915529722-EPS15L1chr1916532287-0.0053726190.9946274
ENST00000397410ENST00000602009AKAP8Lchr1915529722-EPS15L1chr1916532287-0.0014039620.998596
ENST00000397410ENST00000597937AKAP8Lchr1915529722-EPS15L1chr1916532287-0.0014039620.998596
ENST00000595465ENST00000455140AKAP8Lchr1915529722-EPS15L1chr1916532287-0.0092327640.9907672
ENST00000595465ENST00000248070AKAP8Lchr1915529722-EPS15L1chr1916532287-0.0067988580.9932012
ENST00000595465ENST00000535753AKAP8Lchr1915529722-EPS15L1chr1916532287-0.0045860480.9954139
ENST00000595465ENST00000594975AKAP8Lchr1915529722-EPS15L1chr1916532287-0.0050234470.99497664
ENST00000595465ENST00000602009AKAP8Lchr1915529722-EPS15L1chr1916532287-0.001435980.99856406
ENST00000595465ENST00000597937AKAP8Lchr1915529722-EPS15L1chr1916532287-0.001435980.99856406

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Fusion Genomic Features for AKAP8L-EPS15L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AKAP8L-EPS15L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:15529722/chr19:16532287)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823386_553264865.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824386_553264911.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822386_553264755.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816386_553264602.0Coiled coilOntology_term=ECO:0000255
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823750_816264865.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824750_816264911.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822750_816264755.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816750_816264602.0Compositional biasNote=Pro-rich
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823275_365264865.0DomainEH 3
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824275_365264911.0DomainEH 3
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822275_365264755.0DomainEH 3
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816275_365264602.0DomainEH 3
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823618_835264865.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824618_835264911.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822618_835264755.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816618_835264602.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823618_620264865.0RepeatNote=1
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823640_642264865.0RepeatNote=2
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823645_647264865.0RepeatNote=3
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823650_652264865.0RepeatNote=4
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823656_658264865.0RepeatNote=5
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823661_663264865.0RepeatNote=6
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823667_669264865.0RepeatNote=7
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823685_687264865.0RepeatNote=8
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823690_692264865.0RepeatNote=9
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823709_711264865.0RepeatNote=10
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823728_730264865.0RepeatNote=11
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823754_756264865.0RepeatNote=12
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823806_808264865.0RepeatNote=13
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823812_814264865.0RepeatNote=14
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823833_835264865.0RepeatNote=15
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824618_620264911.0RepeatNote=1
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824640_642264911.0RepeatNote=2
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824645_647264911.0RepeatNote=3
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824650_652264911.0RepeatNote=4
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824656_658264911.0RepeatNote=5
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824661_663264911.0RepeatNote=6
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824667_669264911.0RepeatNote=7
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824685_687264911.0RepeatNote=8
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824690_692264911.0RepeatNote=9
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824709_711264911.0RepeatNote=10
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824728_730264911.0RepeatNote=11
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824754_756264911.0RepeatNote=12
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824806_808264911.0RepeatNote=13
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824812_814264911.0RepeatNote=14
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824833_835264911.0RepeatNote=15
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822618_620264755.0RepeatNote=1
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822640_642264755.0RepeatNote=2
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822645_647264755.0RepeatNote=3
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822650_652264755.0RepeatNote=4
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822656_658264755.0RepeatNote=5
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822661_663264755.0RepeatNote=6
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822667_669264755.0RepeatNote=7
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822685_687264755.0RepeatNote=8
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822690_692264755.0RepeatNote=9
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822709_711264755.0RepeatNote=10
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822728_730264755.0RepeatNote=11
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822754_756264755.0RepeatNote=12
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822806_808264755.0RepeatNote=13
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822812_814264755.0RepeatNote=14
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822833_835264755.0RepeatNote=15
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816618_620264602.0RepeatNote=1
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816640_642264602.0RepeatNote=2
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816645_647264602.0RepeatNote=3
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816650_652264602.0RepeatNote=4
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816656_658264602.0RepeatNote=5
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816661_663264602.0RepeatNote=6
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816667_669264602.0RepeatNote=7
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816685_687264602.0RepeatNote=8
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816690_692264602.0RepeatNote=9
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816709_711264602.0RepeatNote=10
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816728_730264602.0RepeatNote=11
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816754_756264602.0RepeatNote=12
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816806_808264602.0RepeatNote=13
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816812_814264602.0RepeatNote=14
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816833_835264602.0RepeatNote=15

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000397410-11441_524647.0Compositional biasNote=Gly/Tyr-rich
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000397410-114589_5974647.0Compositional biasNote=Pro-rich
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000397410-114602_6084647.0Compositional biasNote=Pro-rich
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000595465-11441_524586.0Compositional biasNote=Gly/Tyr-rich
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000595465-114589_5974586.0Compositional biasNote=Pro-rich
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000595465-114602_6084586.0Compositional biasNote=Pro-rich
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000397410-114274_2794647.0MotifNuclear localization signal
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000397410-114280_2964647.0MotifNuclear export signal (NES)
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000397410-114362_3644647.0MotifNuclear localization signal
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000595465-114274_2794586.0MotifNuclear localization signal
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000595465-114280_2964586.0MotifNuclear export signal (NES)
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000595465-114362_3644586.0MotifNuclear localization signal
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000397410-1141_2684647.0RegionSufficient for activation of CTE-mediated expression
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000595465-1141_2684586.0RegionSufficient for activation of CTE-mediated expression
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000397410-114391_4134647.0Zinc fingerC2H2 AKAP95-type 1
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000397410-114484_5074647.0Zinc fingerC2H2 AKAP95-type 2
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000595465-114391_4134586.0Zinc fingerC2H2 AKAP95-type 1
HgeneAKAP8Lchr19:15529722chr19:16532287ENST00000595465-114484_5074586.0Zinc fingerC2H2 AKAP95-type 2
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823172_184264865.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824172_184264911.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822172_184264755.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816172_184264602.0Calcium bindingOntology_term=ECO:0000255
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823127_215264865.0DomainEH 2
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000248070823159_194264865.0DomainEF-hand
TgeneEPS15L1chr19:15529722chr19:16532287ENST0000024807082315_104264865.0DomainEH 1
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824127_215264911.0DomainEH 2
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000455140824159_194264911.0DomainEF-hand
TgeneEPS15L1chr19:15529722chr19:16532287ENST0000045514082415_104264911.0DomainEH 1
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822127_215264755.0DomainEH 2
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000535753822159_194264755.0DomainEF-hand
TgeneEPS15L1chr19:15529722chr19:16532287ENST0000053575382215_104264755.0DomainEH 1
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816127_215264602.0DomainEH 2
TgeneEPS15L1chr19:15529722chr19:16532287ENST00000597937816159_194264602.0DomainEF-hand
TgeneEPS15L1chr19:15529722chr19:16532287ENST0000059793781615_104264602.0DomainEH 1


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Fusion Gene Sequence for AKAP8L-EPS15L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3374_3374_1_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000397410_EPS15L1_chr19_16532287_ENST00000248070_length(transcript)=2136nt_BP=144nt
GAGCCAATGCGGTCGGGAGGCGGGGCTCGGGTGTGTGTGGAGGGGACCCTGTGGTTAGCAGCAGCTATCGCAGCGTCGGATGTTCAGAGC
AGCAGAAGCCGGCGTCGTCGGATGTTGTGTTGCCCGCCACCATGAGCTACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAG
ATGCGATTTGATGAGATATTCCTGAAGACCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCG
GGCCTCACCCAGAACCTTCTAGCACACATATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCT
ATGTATTTCATTCAGCAGAAGGTCAGTAAAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACG
CCCGGCCCGGACAGTTCAGGCTCTCTCGGCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTA
CAAAGAGAGAAATATTCACTGGAACAAGACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAAT
GACCTAGACCGGGAAACAAGCAGTTTGCAGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAG
GCCAAGCTCCGAGACATGCTGAGCGACGTCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCT
CAGGAATCTGACTTAAAGTCCCAGGAAGACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAG
CAGAGCATTCAGGCTGGGCGAGTCCAGCTGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAA
CTTTCCCAGCTGCATGAAAGCCGCCAGGAGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTG
ACCGACCTGGCCAACCTGAGCGAAGGCGTCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGATGATCCTTTCAAAAATAAAGCCTTG
TTATTTAGCAACAACACGCAAGAGTTGCATCCGGATCCTTTCCAGACAGAAGACCCCTTCAAATCTGACCCATTTAAAGGAGCTGACCCC
TTCAAAGGCGACCCGTTCCAGAATGACCCCTTTGCAGAACAGCAGACAACTTCAACAGATCCATTTGGAGGGGACCCTTTCAAAGAAAGT
GACCCATTCCGTGGCTCTGCCACTGACGACTTCTTCAAGAAACAGACAAAGAATGACCCATTTACCTCGGATCCATTCACGAAAAACCCT
TCCTTACCTTCGAAGCTCGACCCCTTTGAATCCAGTGATCCCTTTTCATCCTCCAGTGTCTCCTCAAAAGGATCAGATCCCTTTGGAACC
TTAGATCCCTTCGGAAGTGGGTCCTTCAATAGTGCTGAAGGCTTTGCCGACTTCAGCCAGATGTCCAAGCCCCCACCTTCTGGCCCTTTC
ACCTCCTCCTTGGGAGGGGCAGGATTCTCAGATGACCCCTTTAAAAGTAAACAGGACACTCCTGCTCTGCCTCCGAAGAAACCTGCTCCT
CCACGGCCTAAACCGCCCAGCGGTAAAAGTACACCTGTAAGCCAGCTTGGTTCCGCAGACTTTCCCGAGGCCCCCGATCCATTCCAGCCA
CTCGGGGCTGACAGCGGCGACCCGTTCCAAAGTAAAAAGGGGTTTGGGGACCCGTTTAGTGGAAAAGACCCATTTGTCCCCTCCTCTGCA
GCTAAACCTTCTAAGGCCTCTGCCTCGGGCTTTGCAGACTTCACCTCTGTAAGTTGAGTCCTCCGCCTCCGGGCCACCCCACTCCCTTCC
GCTTGCAGCTTCCCTGGGATTTTTGTCTCCTTTTAAAGGCAAACCTCCCAGCTTCTTTAGCCTCTTGGTACCTCACACTCTCTGTCCCTC

>3374_3374_1_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000397410_EPS15L1_chr19_16532287_ENST00000248070_length(amino acids)=588AA_BP=
MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT
PGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQK
AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK
LSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADP
FKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKGSDPFGT
LDPFGSGSFNSAEGFADFSQMSKPPPSGPFTSSLGGAGFSDDPFKSKQDTPALPPKKPAPPRPKPPSGKSTPVSQLGSADFPEAPDPFQP

--------------------------------------------------------------
>3374_3374_2_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000397410_EPS15L1_chr19_16532287_ENST00000455140_length(transcript)=2551nt_BP=144nt
GAGCCAATGCGGTCGGGAGGCGGGGCTCGGGTGTGTGTGGAGGGGACCCTGTGGTTAGCAGCAGCTATCGCAGCGTCGGATGTTCAGAGC
AGCAGAAGCCGGCGTCGTCGGATGTTGTGTTGCCCGCCACCATGAGCTACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAG
ATGCGATTTGATGAGATATTCCTGAAGACCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCG
GGCCTCACCCAGAACCTTCTAGCACACATATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCT
ATGTATTTCATTCAGCAGAAGGTCAGTAAAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACG
CCCGGCCCGGACAGTTCAGGCTCTCTCGGCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTA
CAAAGAGAGAAATATTCACTGGAACAAGACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAAT
GACCTAGACCGGGAAACAAGCAGTTTGCAGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAG
GCCAAGCTCCGAGACATGCTGAGCGACGTCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCT
CAGGAATCTGACTTAAAGTCCCAGGAAGACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAG
CAGAGCATTCAGGCTGGGCGAGTCCAGCTGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAA
CTTTCCCAGCTGCATGAAAGCCGCCAGGAGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTG
ACCGACCTGGCCAACCTGAGCGAAGGCGTCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGATGATCCTTTCAAAAATAAAGCCTTG
TTATTTAGCAACAACACGCAAGAGTTGCATCCGGATCCTTTCCAGACAGAAGACCCCTTCAAATCTGACCCATTTAAAGGAGCTGACCCC
TTCAAAGGCGACCCGTTCCAGAATGACCCCTTTGCAGAACAGCAGACAACTTCAACAGATCCATTTGGAGGGGACCCTTTCAAAGAAAGT
GACCCATTCCGTGGCTCTGCCACTGACGACTTCTTCAAGAAACAGACAAAGAATGACCCATTTACCTCGGATCCATTCACGAAAAACCCT
TCCTTACCTTCGAAGCTCGACCCCTTTGAATCCAGTGATCCCTTTTCATCCTCCAGTGTCTCCTCAAAAGGATCAGATCCCTTTGGAACC
TTAGATCCCTTCGGAAGTGGGTCCTTCAATAGTGCTGAAGGCTTTGCCGACTTCAGCCAGATGTCCAAGCCCCCACCTTCTGGCCCTTTC
ACCTCCTCCTTGGGAGGGGCAGGATTCTCAGATGACCCCTTTAAAAGTAAACAGGACACTCCTGCTCTGCCTCCGAAGAAACCTGCTCCT
CCACGGCCTAAACCGCCCAGCGGTAAAAGTACACCTGTAAGCCAGCTTGGTTCCGCAGACTTTCCCGAGGCCCCCGATCCATTCCAGCCA
CTCGGGGCTGACAGCGGCGACCCGTTCCAAAGTAAAAAGGGGTTTGGGGACCCGTTTAGTGGAAAAGACCCATTTGTCCCCTCCTCTGCA
GCTAAACCTTCTAAGGCCTCTGCCTCGGGCTTTGCAGACTTCACCTCTTTTGGCAATGAGGAGCAGCAGCTGGCGTGGGCCAAGCGGGAG
AGCGAGAAGGCGGAACAGGAGAGGCTGGCGCGGCTGCGGCGGCAGGAGCAGGAGGACCTGGAACTGGCCATCGCGCTCAGCAAGGCTGAC
ATGCCTGCCGCCTAGGCGAGGGCCGTGTGTAGGCGGGACAGGGCACGGGCGGGTTCCAGAGAGGGGGCAGTGCAGATGTCTATATATACA
CACACACACCGTCGCCACCGTACTCCAAGGACCGGGACTCGGGGGCTTGTTCAGGGTGAGCAGACTCGGCTGCAAGACCTGGAAAGGTCA
CATCTCCTGGGGAAGCCCTTACAGAGGCCTTGGCCACCACTTCTGCAGGTCCGTCTCTCCACTGTGCCATCCCCCCCGGGGCTGACTGCC
TCCCGCTCTTCCTCTGGGGACGAACACACAGCGGTCAGTCGAGGAGAGGAAGCACCCAGGGCTTCCCCGCCTCCTCCCTACTCATAGCTG
CAGACATCCCCACCCGCCCTCCCACGCATCAGTCAGACACTCCCCCAGTGGTGTATGCACTCGTTGTATAAAATGAAGTTTGAATGATTA

>3374_3374_2_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000397410_EPS15L1_chr19_16532287_ENST00000455140_length(amino acids)=634AA_BP=
MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT
PGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQK
AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK
LSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADP
FKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKGSDPFGT
LDPFGSGSFNSAEGFADFSQMSKPPPSGPFTSSLGGAGFSDDPFKSKQDTPALPPKKPAPPRPKPPSGKSTPVSQLGSADFPEAPDPFQP
LGADSGDPFQSKKGFGDPFSGKDPFVPSSAAKPSKASASGFADFTSFGNEEQQLAWAKRESEKAEQERLARLRRQEQEDLELAIALSKAD

--------------------------------------------------------------
>3374_3374_3_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000397410_EPS15L1_chr19_16532287_ENST00000535753_length(transcript)=1987nt_BP=144nt
GAGCCAATGCGGTCGGGAGGCGGGGCTCGGGTGTGTGTGGAGGGGACCCTGTGGTTAGCAGCAGCTATCGCAGCGTCGGATGTTCAGAGC
AGCAGAAGCCGGCGTCGTCGGATGTTGTGTTGCCCGCCACCATGAGCTACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAG
ATGCGATTTGATGAGATATTCCTGAAGACCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCG
GGCCTCACCCAGAACCTTCTAGCACACATATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCT
ATGTATTTCATTCAGCAGAAGGTCAGTAAAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACG
CCCGGCCCGGACAGTTCAGGCTCTCTCGGCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTA
CAAAGAGAGAAATATTCACTGGAACAAGACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAAT
GACCTAGACCGGGAAACAAGCAGTTTGCAGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAG
GCCAAGCTCCGAGACATGCTGAGCGACGTCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCT
CAGGAATCTGACTTAAAGTCCCAGGAAGACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAG
CAGAGCATTCAGGCTGGGCGAGTCCAGCTGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAA
CTTTCCCAGCTGCATGAAAGCCGCCAGGAGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTG
ACCGACCTGGCCAACCTGAGCGAAGGCGTCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGATGATCCTTTCAAAAATAAAGCCTTG
TTATTTAGCAACAACACGCAAGAGTTGCATCCGGATCCTTTCCAGACAGAAGACCCCTTCAAATCTGACCCATTTAAAGGAGCTGACCCC
TTCAAAGGCGACCCGTTCCAGAATGACCCCTTTGCAGAACAGCAGACAACTTCAACAGATCCATTTGGAGGGGACCCTTTCAAAGAAAGT
GACCCATTCCGTGGCTCTGCCACTGACGACTTCTTCAAGAAACAGACAAAGAATGACCCATTTACCTCGGATCCATTCACGAAAAACCCT
TCCTTACCTTCGAAGCTCGACCCCTTTGAATCCAGTGATCCCTTTTCATCCTCCAGTGTCTCCTCAAAAGGATCAGATCCCTTTGGAACC
TTAGATCCCTTCGGAAGTGGGTCCTTCAATAGTGCTGAAGGCTTTGCCGACTTCAGCCAGATGTCCAAGGTAAAAGTACACCTGTAAGCC
AGCTTGGTTCCGCAGACTTTCCCGAGGCCCCCGATCCATTCCAGCCACTCGGGGCTGACAGCGGCGACCCGTTCCAAAGTAAAAAGGGGT
TTGGGGACCCGTTTAGTGGAAAAGACCCATTTGTCCCCTCCTCTGCAGCTAAACCTTCTAAGGCCTCTGCCTCGGGCTTTGCAGACTTCA
CCTCTGTAAGTTGAGTCCTCCGCCTCCGGGCCACCCCACTCCCTTCCGCTTGCAGCTTCCCTGGGATTTTTGTCTCCTTTTAAAGGCAAA
CCTCCCAGCTTCTTTAGCCTCTTGGTACCTCACACTCTCTGTCCCTCGCGTTATTTATTCTACACTGCCACTTCTGTAAGAAAAACAGTT

>3374_3374_3_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000397410_EPS15L1_chr19_16532287_ENST00000535753_length(amino acids)=478AA_BP=
MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT
PGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQK
AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK
LSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADP
FKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKGSDPFGT

--------------------------------------------------------------
>3374_3374_4_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000397410_EPS15L1_chr19_16532287_ENST00000594975_length(transcript)=1701nt_BP=144nt
GAGCCAATGCGGTCGGGAGGCGGGGCTCGGGTGTGTGTGGAGGGGACCCTGTGGTTAGCAGCAGCTATCGCAGCGTCGGATGTTCAGAGC
AGCAGAAGCCGGCGTCGTCGGATGTTGTGTTGCCCGCCACCATGAGCTACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAG
ATGCGATTTGATGAGATATTCCTGAAGACCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCG
GGCCTCACCCAGAACCTTCTAGCACACATATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCT
ATGTATTTCATTCAGCAGAAGGTCAGTAAAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACG
CCCGGCCCGGACAGTTCAGGCTCTCTCGGCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTA
CAAAGAGAGAAATATTCACTGGAACAAGACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAAT
GACCTAGACCGGGAAACAAGCAGTTTGCAGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAG
GCCAAGCTCCGAGACATGCTGAGCGACGTCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCT
CAGGAATCTGACTTAAAGTCCCAGGAAGACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAG
CAGAGCATTCAGGCTGGGCGAGTCCAGCTGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAA
CTTTCCCAGCTGCATGAAAGCCGCCAGGAGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTG
ACCGACCTGGCCAACCTGAGCGAAGGCGTCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGTAAAGGATGATCCTTTCAAAAATAAA
GCCTTGTTATTTAGCAACAACACGCAAGAGTTGCATCCGGATCCTTTCCAGACAGAAGACCCCTTCAAATCTGACCCATTTAAAGGAGCT
GACCCCTTCAAAGGCGACCCGTTCCAGAATGACCCCTTTGCAGAACAGCAGACAACTTCAACAGATCCATTTGGAGGGGACCCTTTCAAA
GAAAGTGACCCATTCCGTGGCTCTGCCACTGACGACTTCTTCAAGAAACAGACAAAGAATGACCCATTTACCTCGGATCCATTCACGAAA
AACCCTTCCTTACCTTCGAAGCTCGACCCCTTTGAATCCAGTGATCCCTTTTCATCCTCCAGTGTCTCCTCAAAAGGATCAGATCCCTTT
GGAACCTTAGATCCCTTCGGAAGTGGGTCCTTCAATAGTGCTGAAGGCTTTGCCGACTTCAGCCAGATGTCCAAGGTAAAAGTACACCTG

>3374_3374_4_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000397410_EPS15L1_chr19_16532287_ENST00000594975_length(amino acids)=480AA_BP=
MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT
PGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQK
AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK
LSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMVKDDPFKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGA
DPFKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKGSDPF

--------------------------------------------------------------
>3374_3374_5_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000397410_EPS15L1_chr19_16532287_ENST00000597937_length(transcript)=2833nt_BP=144nt
GAGCCAATGCGGTCGGGAGGCGGGGCTCGGGTGTGTGTGGAGGGGACCCTGTGGTTAGCAGCAGCTATCGCAGCGTCGGATGTTCAGAGC
AGCAGAAGCCGGCGTCGTCGGATGTTGTGTTGCCCGCCACCATGAGCTACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAG
ATGCGATTTGATGAGATATTCCTGAAGACCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCG
GGCCTCACCCAGAACCTTCTAGCACACATATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCT
ATGTATTTCATTCAGCAGAAGGTCAGTAAAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACG
CCCGGCCCGGACAGTTCAGGCTCTCTCGGCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTA
CAAAGAGAGAAATATTCACTGGAACAAGACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAAT
GACCTAGACCGGGAAACAAGCAGTTTGCAGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAG
GCCAAGCTCCGAGACATGCTGAGCGACGTCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCT
CAGGAATCTGACTTAAAGTCCCAGGAAGACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAG
CAGAGCATTCAGGCTGGGCGAGTCCAGCTGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAA
CTTTCCCAGCTGCATGAAAGCCGCCAGGAGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTG
ACCGACCTGGCCAACCTGAGCGAAGGCGTCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGTAAAGGTTGAATAAACGTATTACAGT
ATGGGGCTCTGGTCCCCTGGTGTGACAGCAGAACATCCCACCCGCCAGATCTGTTCATGGCCAACGTTGGTTCCAGCCAAGTGCAGGCGG
CTGTCTGTTGTTTTTGCTGCCACTTTGCGCGTTCACACCAGGCCTTGCAGCCTGGCACAGGTGGCCATGCTGAATCCTGGCTTCCAGAAC
AAAGTCCAAGATAGGCCTGGATCCTTTCAGAACCTGTTTTGAATGCCCTCCATCTCTGCGGAAGTATTTACATTGGGCCAACCACCCAAG
TTCAGAGGGCTTCTCAAACTTAACCAAAATTGGATCAGTTTCTGCTCATTGTGGAAACCCCACATTCTACTAATCAGGGGGCAGGGGACA
TCTGAGGGGCATGTGTCTATGTGTATGTGTGTTTCCACAAGGAACACCTTGAAAAGCAAATGTGTTGCTAAAGATGAGGAAGTAATGGCA
AGCAGCGCCCCAGGGTGTTGCTCTTTCAAGTAAGAATTGGCCTCTCCTGAAATTTTGGTTATGTTTAAAAACCTCTGCACTTTACTCTGA
CCTCATGACCCTGGAGTTGTGATCAGGCCTGGGGCAGGGGACTGTCGGCCCCTTACATTTTTGAGAGCTCTTGAGCCCCTGATACCAAGA
CAGGTGTGACCTTTTCCTTAGGTGGTCACATCCCCCCTGTTCACACCAGAGTCTGCCCCTGCAGCCTCGAACCTGGGGACATGTAGTTTC
CCATTTCGTCTTGGTGCTGTTCCGGGAGCGGATGGGCCGGGCCGCGCATGTCTGGATGTTTCCTTGGTGCTCTGCTGCCTCCAGCAGCTC
TCTCCGTGCTGCCACCCTCTCTCCCAGGGCTCCTCCCTGGAGCCCTTCTGCTCCTGGGCCTCTGTACGTCATGGATTCCTCTTCCTCCCT
GGAATAAGAGTGAGCGCTCGTGCTCTCTAAACACCACACTTGCCTCTTTATGTTCAATGCTTGATGTGTTTCTTTTCTCAGCAGCCAAGT
CCTCAGTCCCAAGGATTTATGGGGAAGCACACGCGTCCCCTGGGCTGCTGGGAAGGCACTGCTGGCGAGCTCATCTGTCTCTTGTGTCTG
GCCCCCGCTGGGTGCACCGCCTCCCTCTTTCCTCCCATACTCTCTTTTCTCGTGGACTCGTAATGAGGTGGTTTCCATAGCCGCCCCCGG
GCCCGTCATCATCAGCTTTATCGTCTAAATTTAAACGATGAGCATTCATCCTTCATGAGTTACGAGAAGCCAGAACTCCTCGCTTTGCTC
CCTGGCTGTTCTTGGCGTGTGTGTTTCCGTCTCACAACCCGGCTCCTACTTTCCCCATCTGGCATTGTCCCCTGGCACCGCTTTTGGCTT
GTCCTGCTCAGTCTTCGTTCAGGGAACAGCTTCCTCTTAAATGTCCCTTTTGCAGGTTTTTAGAAACCGGTTTTCTTGGATAAAAGTTGG
CAGTGAAGTGGCAGTTTGCAAGTGGCCAGTGATTCCCCCAACTCCAAAGACAGATTTTTACCTTTCTGGTTATTTTTGTTCATCTTTTGG
GCAGGGCAAAGGTTACCTGAGACACAATTACTTTGGGAATGTAGATTAAGATACGTTACATGGAAACTTGCAACTGGCATCCGAAAGAAA

>3374_3374_5_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000397410_EPS15L1_chr19_16532287_ENST00000597937_length(amino acids)=325AA_BP=
MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT
PGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQK
AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK

--------------------------------------------------------------
>3374_3374_6_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000397410_EPS15L1_chr19_16532287_ENST00000602009_length(transcript)=2833nt_BP=144nt
GAGCCAATGCGGTCGGGAGGCGGGGCTCGGGTGTGTGTGGAGGGGACCCTGTGGTTAGCAGCAGCTATCGCAGCGTCGGATGTTCAGAGC
AGCAGAAGCCGGCGTCGTCGGATGTTGTGTTGCCCGCCACCATGAGCTACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAG
ATGCGATTTGATGAGATATTCCTGAAGACCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCG
GGCCTCACCCAGAACCTTCTAGCACACATATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCT
ATGTATTTCATTCAGCAGAAGGTCAGTAAAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACG
CCCGGCCCGGACAGTTCAGGCTCTCTCGGCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTA
CAAAGAGAGAAATATTCACTGGAACAAGACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAAT
GACCTAGACCGGGAAACAAGCAGTTTGCAGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAG
GCCAAGCTCCGAGACATGCTGAGCGACGTCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCT
CAGGAATCTGACTTAAAGTCCCAGGAAGACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAG
CAGAGCATTCAGGCTGGGCGAGTCCAGCTGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAA
CTTTCCCAGCTGCATGAAAGCCGCCAGGAGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTG
ACCGACCTGGCCAACCTGAGCGAAGGCGTCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGTAAAGGTTGAATAAACGTATTACAGT
ATGGGGCTCTGGTCCCCTGGTGTGACAGCAGAACATCCCACCCGCCAGATCTGTTCATGGCCAACGTTGGTTCCAGCCAAGTGCAGGCGG
CTGTCTGTTGTTTTTGCTGCCACTTTGCGCGTTCACACCAGGCCTTGCAGCCTGGCACAGGTGGCCATGCTGAATCCTGGCTTCCAGAAC
AAAGTCCAAGATAGGCCTGGATCCTTTCAGAACCTGTTTTGAATGCCCTCCATCTCTGCGGAAGTATTTACATTGGGCCAACCACCCAAG
TTCAGAGGGCTTCTCAAACTTAACCAAAATTGGATCAGTTTCTGCTCATTGTGGAAACCCCACATTCTACTAATCAGGGGGCAGGGGACA
TCTGAGGGGCATGTGTCTATGTGTATGTGTGTTTCCACAAGGAACACCTTGAAAAGCAAATGTGTTGCTAAAGATGAGGAAGTAATGGCA
AGCAGCGCCCCAGGGTGTTGCTCTTTCAAGTAAGAATTGGCCTCTCCTGAAATTTTGGTTATGTTTAAAAACCTCTGCACTTTACTCTGA
CCTCATGACCCTGGAGTTGTGATCAGGCCTGGGGCAGGGGACTGTCGGCCCCTTACATTTTTGAGAGCTCTTGAGCCCCTGATACCAAGA
CAGGTGTGACCTTTTCCTTAGGTGGTCACATCCCCCCTGTTCACACCAGAGTCTGCCCCTGCAGCCTCGAACCTGGGGACATGTAGTTTC
CCATTTCGTCTTGGTGCTGTTCCGGGAGCGGATGGGCCGGGCCGCGCATGTCTGGATGTTTCCTTGGTGCTCTGCTGCCTCCAGCAGCTC
TCTCCGTGCTGCCACCCTCTCTCCCAGGGCTCCTCCCTGGAGCCCTTCTGCTCCTGGGCCTCTGTACGTCATGGATTCCTCTTCCTCCCT
GGAATAAGAGTGAGCGCTCGTGCTCTCTAAACACCACACTTGCCTCTTTATGTTCAATGCTTGATGTGTTTCTTTTCTCAGCAGCCAAGT
CCTCAGTCCCAAGGATTTATGGGGAAGCACACGCGTCCCCTGGGCTGCTGGGAAGGCACTGCTGGCGAGCTCATCTGTCTCTTGTGTCTG
GCCCCCGCTGGGTGCACCGCCTCCCTCTTTCCTCCCATACTCTCTTTTCTCGTGGACTCGTAATGAGGTGGTTTCCATAGCCGCCCCCGG
GCCCGTCATCATCAGCTTTATCGTCTAAATTTAAACGATGAGCATTCATCCTTCATGAGTTACGAGAAGCCAGAACTCCTCGCTTTGCTC
CCTGGCTGTTCTTGGCGTGTGTGTTTCCGTCTCACAACCCGGCTCCTACTTTCCCCATCTGGCATTGTCCCCTGGCACCGCTTTTGGCTT
GTCCTGCTCAGTCTTCGTTCAGGGAACAGCTTCCTCTTAAATGTCCCTTTTGCAGGTTTTTAGAAACCGGTTTTCTTGGATAAAAGTTGG
CAGTGAAGTGGCAGTTTGCAAGTGGCCAGTGATTCCCCCAACTCCAAAGACAGATTTTTACCTTTCTGGTTATTTTTGTTCATCTTTTGG
GCAGGGCAAAGGTTACCTGAGACACAATTACTTTGGGAATGTAGATTAAGATACGTTACATGGAAACTTGCAACTGGCATCCGAAAGAAA

>3374_3374_6_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000397410_EPS15L1_chr19_16532287_ENST00000602009_length(amino acids)=325AA_BP=
MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT
PGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQK
AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK

--------------------------------------------------------------
>3374_3374_7_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000595465_EPS15L1_chr19_16532287_ENST00000248070_length(transcript)=2108nt_BP=116nt
GGGTGTGTGTGGAGGGGACCCTGTGGTTAGCAGCAGCTATCGCAGCGTCGGATGTTCAGAGCAGCAGAAGCCGGCGTCGTCGGATGTTGT
GTTGCCCGCCACCATGAGCTACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAGATGCGATTTGATGAGATATTCCTGAAGA
CCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCGGGCCTCACCCAGAACCTTCTAGCACACA
TATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCTATGTATTTCATTCAGCAGAAGGTCAGTA
AAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACGCCCGGCCCGGACAGTTCAGGCTCTCTCG
GCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTACAAAGAGAGAAATATTCACTGGAACAAG
ACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAATGACCTAGACCGGGAAACAAGCAGTTTGC
AGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAGGCCAAGCTCCGAGACATGCTGAGCGACG
TCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCTCAGGAATCTGACTTAAAGTCCCAGGAAG
ACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAGCAGAGCATTCAGGCTGGGCGAGTCCAGC
TGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAACTTTCCCAGCTGCATGAAAGCCGCCAGG
AGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTGACCGACCTGGCCAACCTGAGCGAAGGCG
TCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGATGATCCTTTCAAAAATAAAGCCTTGTTATTTAGCAACAACACGCAAGAGTTGC
ATCCGGATCCTTTCCAGACAGAAGACCCCTTCAAATCTGACCCATTTAAAGGAGCTGACCCCTTCAAAGGCGACCCGTTCCAGAATGACC
CCTTTGCAGAACAGCAGACAACTTCAACAGATCCATTTGGAGGGGACCCTTTCAAAGAAAGTGACCCATTCCGTGGCTCTGCCACTGACG
ACTTCTTCAAGAAACAGACAAAGAATGACCCATTTACCTCGGATCCATTCACGAAAAACCCTTCCTTACCTTCGAAGCTCGACCCCTTTG
AATCCAGTGATCCCTTTTCATCCTCCAGTGTCTCCTCAAAAGGATCAGATCCCTTTGGAACCTTAGATCCCTTCGGAAGTGGGTCCTTCA
ATAGTGCTGAAGGCTTTGCCGACTTCAGCCAGATGTCCAAGCCCCCACCTTCTGGCCCTTTCACCTCCTCCTTGGGAGGGGCAGGATTCT
CAGATGACCCCTTTAAAAGTAAACAGGACACTCCTGCTCTGCCTCCGAAGAAACCTGCTCCTCCACGGCCTAAACCGCCCAGCGGTAAAA
GTACACCTGTAAGCCAGCTTGGTTCCGCAGACTTTCCCGAGGCCCCCGATCCATTCCAGCCACTCGGGGCTGACAGCGGCGACCCGTTCC
AAAGTAAAAAGGGGTTTGGGGACCCGTTTAGTGGAAAAGACCCATTTGTCCCCTCCTCTGCAGCTAAACCTTCTAAGGCCTCTGCCTCGG
GCTTTGCAGACTTCACCTCTGTAAGTTGAGTCCTCCGCCTCCGGGCCACCCCACTCCCTTCCGCTTGCAGCTTCCCTGGGATTTTTGTCT
CCTTTTAAAGGCAAACCTCCCAGCTTCTTTAGCCTCTTGGTACCTCACACTCTCTGTCCCTCGCGTTATTTATTCTACACTGCCACTTCT

>3374_3374_7_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000595465_EPS15L1_chr19_16532287_ENST00000248070_length(amino acids)=588AA_BP=
MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT
PGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQK
AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK
LSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADP
FKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKGSDPFGT
LDPFGSGSFNSAEGFADFSQMSKPPPSGPFTSSLGGAGFSDDPFKSKQDTPALPPKKPAPPRPKPPSGKSTPVSQLGSADFPEAPDPFQP

--------------------------------------------------------------
>3374_3374_8_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000595465_EPS15L1_chr19_16532287_ENST00000455140_length(transcript)=2523nt_BP=116nt
GGGTGTGTGTGGAGGGGACCCTGTGGTTAGCAGCAGCTATCGCAGCGTCGGATGTTCAGAGCAGCAGAAGCCGGCGTCGTCGGATGTTGT
GTTGCCCGCCACCATGAGCTACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAGATGCGATTTGATGAGATATTCCTGAAGA
CCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCGGGCCTCACCCAGAACCTTCTAGCACACA
TATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCTATGTATTTCATTCAGCAGAAGGTCAGTA
AAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACGCCCGGCCCGGACAGTTCAGGCTCTCTCG
GCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTACAAAGAGAGAAATATTCACTGGAACAAG
ACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAATGACCTAGACCGGGAAACAAGCAGTTTGC
AGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAGGCCAAGCTCCGAGACATGCTGAGCGACG
TCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCTCAGGAATCTGACTTAAAGTCCCAGGAAG
ACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAGCAGAGCATTCAGGCTGGGCGAGTCCAGC
TGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAACTTTCCCAGCTGCATGAAAGCCGCCAGG
AGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTGACCGACCTGGCCAACCTGAGCGAAGGCG
TCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGATGATCCTTTCAAAAATAAAGCCTTGTTATTTAGCAACAACACGCAAGAGTTGC
ATCCGGATCCTTTCCAGACAGAAGACCCCTTCAAATCTGACCCATTTAAAGGAGCTGACCCCTTCAAAGGCGACCCGTTCCAGAATGACC
CCTTTGCAGAACAGCAGACAACTTCAACAGATCCATTTGGAGGGGACCCTTTCAAAGAAAGTGACCCATTCCGTGGCTCTGCCACTGACG
ACTTCTTCAAGAAACAGACAAAGAATGACCCATTTACCTCGGATCCATTCACGAAAAACCCTTCCTTACCTTCGAAGCTCGACCCCTTTG
AATCCAGTGATCCCTTTTCATCCTCCAGTGTCTCCTCAAAAGGATCAGATCCCTTTGGAACCTTAGATCCCTTCGGAAGTGGGTCCTTCA
ATAGTGCTGAAGGCTTTGCCGACTTCAGCCAGATGTCCAAGCCCCCACCTTCTGGCCCTTTCACCTCCTCCTTGGGAGGGGCAGGATTCT
CAGATGACCCCTTTAAAAGTAAACAGGACACTCCTGCTCTGCCTCCGAAGAAACCTGCTCCTCCACGGCCTAAACCGCCCAGCGGTAAAA
GTACACCTGTAAGCCAGCTTGGTTCCGCAGACTTTCCCGAGGCCCCCGATCCATTCCAGCCACTCGGGGCTGACAGCGGCGACCCGTTCC
AAAGTAAAAAGGGGTTTGGGGACCCGTTTAGTGGAAAAGACCCATTTGTCCCCTCCTCTGCAGCTAAACCTTCTAAGGCCTCTGCCTCGG
GCTTTGCAGACTTCACCTCTTTTGGCAATGAGGAGCAGCAGCTGGCGTGGGCCAAGCGGGAGAGCGAGAAGGCGGAACAGGAGAGGCTGG
CGCGGCTGCGGCGGCAGGAGCAGGAGGACCTGGAACTGGCCATCGCGCTCAGCAAGGCTGACATGCCTGCCGCCTAGGCGAGGGCCGTGT
GTAGGCGGGACAGGGCACGGGCGGGTTCCAGAGAGGGGGCAGTGCAGATGTCTATATATACACACACACACCGTCGCCACCGTACTCCAA
GGACCGGGACTCGGGGGCTTGTTCAGGGTGAGCAGACTCGGCTGCAAGACCTGGAAAGGTCACATCTCCTGGGGAAGCCCTTACAGAGGC
CTTGGCCACCACTTCTGCAGGTCCGTCTCTCCACTGTGCCATCCCCCCCGGGGCTGACTGCCTCCCGCTCTTCCTCTGGGGACGAACACA
CAGCGGTCAGTCGAGGAGAGGAAGCACCCAGGGCTTCCCCGCCTCCTCCCTACTCATAGCTGCAGACATCCCCACCCGCCCTCCCACGCA
TCAGTCAGACACTCCCCCAGTGGTGTATGCACTCGTTGTATAAAATGAAGTTTGAATGATTAATATAAAATATTTTAATACAAAACAAGA

>3374_3374_8_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000595465_EPS15L1_chr19_16532287_ENST00000455140_length(amino acids)=634AA_BP=
MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT
PGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQK
AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK
LSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADP
FKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKGSDPFGT
LDPFGSGSFNSAEGFADFSQMSKPPPSGPFTSSLGGAGFSDDPFKSKQDTPALPPKKPAPPRPKPPSGKSTPVSQLGSADFPEAPDPFQP
LGADSGDPFQSKKGFGDPFSGKDPFVPSSAAKPSKASASGFADFTSFGNEEQQLAWAKRESEKAEQERLARLRRQEQEDLELAIALSKAD

--------------------------------------------------------------
>3374_3374_9_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000595465_EPS15L1_chr19_16532287_ENST00000535753_length(transcript)=1959nt_BP=116nt
GGGTGTGTGTGGAGGGGACCCTGTGGTTAGCAGCAGCTATCGCAGCGTCGGATGTTCAGAGCAGCAGAAGCCGGCGTCGTCGGATGTTGT
GTTGCCCGCCACCATGAGCTACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAGATGCGATTTGATGAGATATTCCTGAAGA
CCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCGGGCCTCACCCAGAACCTTCTAGCACACA
TATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCTATGTATTTCATTCAGCAGAAGGTCAGTA
AAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACGCCCGGCCCGGACAGTTCAGGCTCTCTCG
GCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTACAAAGAGAGAAATATTCACTGGAACAAG
ACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAATGACCTAGACCGGGAAACAAGCAGTTTGC
AGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAGGCCAAGCTCCGAGACATGCTGAGCGACG
TCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCTCAGGAATCTGACTTAAAGTCCCAGGAAG
ACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAGCAGAGCATTCAGGCTGGGCGAGTCCAGC
TGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAACTTTCCCAGCTGCATGAAAGCCGCCAGG
AGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTGACCGACCTGGCCAACCTGAGCGAAGGCG
TCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGATGATCCTTTCAAAAATAAAGCCTTGTTATTTAGCAACAACACGCAAGAGTTGC
ATCCGGATCCTTTCCAGACAGAAGACCCCTTCAAATCTGACCCATTTAAAGGAGCTGACCCCTTCAAAGGCGACCCGTTCCAGAATGACC
CCTTTGCAGAACAGCAGACAACTTCAACAGATCCATTTGGAGGGGACCCTTTCAAAGAAAGTGACCCATTCCGTGGCTCTGCCACTGACG
ACTTCTTCAAGAAACAGACAAAGAATGACCCATTTACCTCGGATCCATTCACGAAAAACCCTTCCTTACCTTCGAAGCTCGACCCCTTTG
AATCCAGTGATCCCTTTTCATCCTCCAGTGTCTCCTCAAAAGGATCAGATCCCTTTGGAACCTTAGATCCCTTCGGAAGTGGGTCCTTCA
ATAGTGCTGAAGGCTTTGCCGACTTCAGCCAGATGTCCAAGGTAAAAGTACACCTGTAAGCCAGCTTGGTTCCGCAGACTTTCCCGAGGC
CCCCGATCCATTCCAGCCACTCGGGGCTGACAGCGGCGACCCGTTCCAAAGTAAAAAGGGGTTTGGGGACCCGTTTAGTGGAAAAGACCC
ATTTGTCCCCTCCTCTGCAGCTAAACCTTCTAAGGCCTCTGCCTCGGGCTTTGCAGACTTCACCTCTGTAAGTTGAGTCCTCCGCCTCCG
GGCCACCCCACTCCCTTCCGCTTGCAGCTTCCCTGGGATTTTTGTCTCCTTTTAAAGGCAAACCTCCCAGCTTCTTTAGCCTCTTGGTAC

>3374_3374_9_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000595465_EPS15L1_chr19_16532287_ENST00000535753_length(amino acids)=478AA_BP=
MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT
PGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQK
AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK
LSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADP
FKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKGSDPFGT

--------------------------------------------------------------
>3374_3374_10_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000595465_EPS15L1_chr19_16532287_ENST00000594975_length(transcript)=1673nt_BP=116nt
GGGTGTGTGTGGAGGGGACCCTGTGGTTAGCAGCAGCTATCGCAGCGTCGGATGTTCAGAGCAGCAGAAGCCGGCGTCGTCGGATGTTGT
GTTGCCCGCCACCATGAGCTACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAGATGCGATTTGATGAGATATTCCTGAAGA
CCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCGGGCCTCACCCAGAACCTTCTAGCACACA
TATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCTATGTATTTCATTCAGCAGAAGGTCAGTA
AAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACGCCCGGCCCGGACAGTTCAGGCTCTCTCG
GCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTACAAAGAGAGAAATATTCACTGGAACAAG
ACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAATGACCTAGACCGGGAAACAAGCAGTTTGC
AGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAGGCCAAGCTCCGAGACATGCTGAGCGACG
TCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCTCAGGAATCTGACTTAAAGTCCCAGGAAG
ACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAGCAGAGCATTCAGGCTGGGCGAGTCCAGC
TGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAACTTTCCCAGCTGCATGAAAGCCGCCAGG
AGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTGACCGACCTGGCCAACCTGAGCGAAGGCG
TCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGTAAAGGATGATCCTTTCAAAAATAAAGCCTTGTTATTTAGCAACAACACGCAAG
AGTTGCATCCGGATCCTTTCCAGACAGAAGACCCCTTCAAATCTGACCCATTTAAAGGAGCTGACCCCTTCAAAGGCGACCCGTTCCAGA
ATGACCCCTTTGCAGAACAGCAGACAACTTCAACAGATCCATTTGGAGGGGACCCTTTCAAAGAAAGTGACCCATTCCGTGGCTCTGCCA
CTGACGACTTCTTCAAGAAACAGACAAAGAATGACCCATTTACCTCGGATCCATTCACGAAAAACCCTTCCTTACCTTCGAAGCTCGACC
CCTTTGAATCCAGTGATCCCTTTTCATCCTCCAGTGTCTCCTCAAAAGGATCAGATCCCTTTGGAACCTTAGATCCCTTCGGAAGTGGGT
CCTTCAATAGTGCTGAAGGCTTTGCCGACTTCAGCCAGATGTCCAAGGTAAAAGTACACCTGTAAGCCAGCTTGGTTCCGCAGACTTTCC

>3374_3374_10_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000595465_EPS15L1_chr19_16532287_ENST00000594975_length(amino acids)=480AA_BP=
MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT
PGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQK
AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK
LSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMVKDDPFKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGA
DPFKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKGSDPF

--------------------------------------------------------------
>3374_3374_11_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000595465_EPS15L1_chr19_16532287_ENST00000597937_length(transcript)=2805nt_BP=116nt
GGGTGTGTGTGGAGGGGACCCTGTGGTTAGCAGCAGCTATCGCAGCGTCGGATGTTCAGAGCAGCAGAAGCCGGCGTCGTCGGATGTTGT
GTTGCCCGCCACCATGAGCTACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAGATGCGATTTGATGAGATATTCCTGAAGA
CCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCGGGCCTCACCCAGAACCTTCTAGCACACA
TATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCTATGTATTTCATTCAGCAGAAGGTCAGTA
AAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACGCCCGGCCCGGACAGTTCAGGCTCTCTCG
GCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTACAAAGAGAGAAATATTCACTGGAACAAG
ACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAATGACCTAGACCGGGAAACAAGCAGTTTGC
AGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAGGCCAAGCTCCGAGACATGCTGAGCGACG
TCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCTCAGGAATCTGACTTAAAGTCCCAGGAAG
ACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAGCAGAGCATTCAGGCTGGGCGAGTCCAGC
TGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAACTTTCCCAGCTGCATGAAAGCCGCCAGG
AGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTGACCGACCTGGCCAACCTGAGCGAAGGCG
TCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGTAAAGGTTGAATAAACGTATTACAGTATGGGGCTCTGGTCCCCTGGTGTGACAG
CAGAACATCCCACCCGCCAGATCTGTTCATGGCCAACGTTGGTTCCAGCCAAGTGCAGGCGGCTGTCTGTTGTTTTTGCTGCCACTTTGC
GCGTTCACACCAGGCCTTGCAGCCTGGCACAGGTGGCCATGCTGAATCCTGGCTTCCAGAACAAAGTCCAAGATAGGCCTGGATCCTTTC
AGAACCTGTTTTGAATGCCCTCCATCTCTGCGGAAGTATTTACATTGGGCCAACCACCCAAGTTCAGAGGGCTTCTCAAACTTAACCAAA
ATTGGATCAGTTTCTGCTCATTGTGGAAACCCCACATTCTACTAATCAGGGGGCAGGGGACATCTGAGGGGCATGTGTCTATGTGTATGT
GTGTTTCCACAAGGAACACCTTGAAAAGCAAATGTGTTGCTAAAGATGAGGAAGTAATGGCAAGCAGCGCCCCAGGGTGTTGCTCTTTCA
AGTAAGAATTGGCCTCTCCTGAAATTTTGGTTATGTTTAAAAACCTCTGCACTTTACTCTGACCTCATGACCCTGGAGTTGTGATCAGGC
CTGGGGCAGGGGACTGTCGGCCCCTTACATTTTTGAGAGCTCTTGAGCCCCTGATACCAAGACAGGTGTGACCTTTTCCTTAGGTGGTCA
CATCCCCCCTGTTCACACCAGAGTCTGCCCCTGCAGCCTCGAACCTGGGGACATGTAGTTTCCCATTTCGTCTTGGTGCTGTTCCGGGAG
CGGATGGGCCGGGCCGCGCATGTCTGGATGTTTCCTTGGTGCTCTGCTGCCTCCAGCAGCTCTCTCCGTGCTGCCACCCTCTCTCCCAGG
GCTCCTCCCTGGAGCCCTTCTGCTCCTGGGCCTCTGTACGTCATGGATTCCTCTTCCTCCCTGGAATAAGAGTGAGCGCTCGTGCTCTCT
AAACACCACACTTGCCTCTTTATGTTCAATGCTTGATGTGTTTCTTTTCTCAGCAGCCAAGTCCTCAGTCCCAAGGATTTATGGGGAAGC
ACACGCGTCCCCTGGGCTGCTGGGAAGGCACTGCTGGCGAGCTCATCTGTCTCTTGTGTCTGGCCCCCGCTGGGTGCACCGCCTCCCTCT
TTCCTCCCATACTCTCTTTTCTCGTGGACTCGTAATGAGGTGGTTTCCATAGCCGCCCCCGGGCCCGTCATCATCAGCTTTATCGTCTAA
ATTTAAACGATGAGCATTCATCCTTCATGAGTTACGAGAAGCCAGAACTCCTCGCTTTGCTCCCTGGCTGTTCTTGGCGTGTGTGTTTCC
GTCTCACAACCCGGCTCCTACTTTCCCCATCTGGCATTGTCCCCTGGCACCGCTTTTGGCTTGTCCTGCTCAGTCTTCGTTCAGGGAACA
GCTTCCTCTTAAATGTCCCTTTTGCAGGTTTTTAGAAACCGGTTTTCTTGGATAAAAGTTGGCAGTGAAGTGGCAGTTTGCAAGTGGCCA
GTGATTCCCCCAACTCCAAAGACAGATTTTTACCTTTCTGGTTATTTTTGTTCATCTTTTGGGCAGGGCAAAGGTTACCTGAGACACAAT
TACTTTGGGAATGTAGATTAAGATACGTTACATGGAAACTTGCAACTGGCATCCGAAAGAAAAACTGTTTTTATCCTGTTGTACAAATAC

>3374_3374_11_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000595465_EPS15L1_chr19_16532287_ENST00000597937_length(amino acids)=325AA_BP=
MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT
PGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQK
AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK

--------------------------------------------------------------
>3374_3374_12_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000595465_EPS15L1_chr19_16532287_ENST00000602009_length(transcript)=2805nt_BP=116nt
GGGTGTGTGTGGAGGGGACCCTGTGGTTAGCAGCAGCTATCGCAGCGTCGGATGTTCAGAGCAGCAGAAGCCGGCGTCGTCGGATGTTGT
GTTGCCCGCCACCATGAGCTACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAGATGCGATTTGATGAGATATTCCTGAAGA
CCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCGGGCCTCACCCAGAACCTTCTAGCACACA
TATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCTATGTATTTCATTCAGCAGAAGGTCAGTA
AAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACGCCCGGCCCGGACAGTTCAGGCTCTCTCG
GCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTACAAAGAGAGAAATATTCACTGGAACAAG
ACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAATGACCTAGACCGGGAAACAAGCAGTTTGC
AGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAGGCCAAGCTCCGAGACATGCTGAGCGACG
TCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCTCAGGAATCTGACTTAAAGTCCCAGGAAG
ACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAGCAGAGCATTCAGGCTGGGCGAGTCCAGC
TGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAACTTTCCCAGCTGCATGAAAGCCGCCAGG
AGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTGACCGACCTGGCCAACCTGAGCGAAGGCG
TCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGTAAAGGTTGAATAAACGTATTACAGTATGGGGCTCTGGTCCCCTGGTGTGACAG
CAGAACATCCCACCCGCCAGATCTGTTCATGGCCAACGTTGGTTCCAGCCAAGTGCAGGCGGCTGTCTGTTGTTTTTGCTGCCACTTTGC
GCGTTCACACCAGGCCTTGCAGCCTGGCACAGGTGGCCATGCTGAATCCTGGCTTCCAGAACAAAGTCCAAGATAGGCCTGGATCCTTTC
AGAACCTGTTTTGAATGCCCTCCATCTCTGCGGAAGTATTTACATTGGGCCAACCACCCAAGTTCAGAGGGCTTCTCAAACTTAACCAAA
ATTGGATCAGTTTCTGCTCATTGTGGAAACCCCACATTCTACTAATCAGGGGGCAGGGGACATCTGAGGGGCATGTGTCTATGTGTATGT
GTGTTTCCACAAGGAACACCTTGAAAAGCAAATGTGTTGCTAAAGATGAGGAAGTAATGGCAAGCAGCGCCCCAGGGTGTTGCTCTTTCA
AGTAAGAATTGGCCTCTCCTGAAATTTTGGTTATGTTTAAAAACCTCTGCACTTTACTCTGACCTCATGACCCTGGAGTTGTGATCAGGC
CTGGGGCAGGGGACTGTCGGCCCCTTACATTTTTGAGAGCTCTTGAGCCCCTGATACCAAGACAGGTGTGACCTTTTCCTTAGGTGGTCA
CATCCCCCCTGTTCACACCAGAGTCTGCCCCTGCAGCCTCGAACCTGGGGACATGTAGTTTCCCATTTCGTCTTGGTGCTGTTCCGGGAG
CGGATGGGCCGGGCCGCGCATGTCTGGATGTTTCCTTGGTGCTCTGCTGCCTCCAGCAGCTCTCTCCGTGCTGCCACCCTCTCTCCCAGG
GCTCCTCCCTGGAGCCCTTCTGCTCCTGGGCCTCTGTACGTCATGGATTCCTCTTCCTCCCTGGAATAAGAGTGAGCGCTCGTGCTCTCT
AAACACCACACTTGCCTCTTTATGTTCAATGCTTGATGTGTTTCTTTTCTCAGCAGCCAAGTCCTCAGTCCCAAGGATTTATGGGGAAGC
ACACGCGTCCCCTGGGCTGCTGGGAAGGCACTGCTGGCGAGCTCATCTGTCTCTTGTGTCTGGCCCCCGCTGGGTGCACCGCCTCCCTCT
TTCCTCCCATACTCTCTTTTCTCGTGGACTCGTAATGAGGTGGTTTCCATAGCCGCCCCCGGGCCCGTCATCATCAGCTTTATCGTCTAA
ATTTAAACGATGAGCATTCATCCTTCATGAGTTACGAGAAGCCAGAACTCCTCGCTTTGCTCCCTGGCTGTTCTTGGCGTGTGTGTTTCC
GTCTCACAACCCGGCTCCTACTTTCCCCATCTGGCATTGTCCCCTGGCACCGCTTTTGGCTTGTCCTGCTCAGTCTTCGTTCAGGGAACA
GCTTCCTCTTAAATGTCCCTTTTGCAGGTTTTTAGAAACCGGTTTTCTTGGATAAAAGTTGGCAGTGAAGTGGCAGTTTGCAAGTGGCCA
GTGATTCCCCCAACTCCAAAGACAGATTTTTACCTTTCTGGTTATTTTTGTTCATCTTTTGGGCAGGGCAAAGGTTACCTGAGACACAAT
TACTTTGGGAATGTAGATTAAGATACGTTACATGGAAACTTGCAACTGGCATCCGAAAGAAAAACTGTTTTTATCCTGTTGTACAAATAC

>3374_3374_12_AKAP8L-EPS15L1_AKAP8L_chr19_15529722_ENST00000595465_EPS15L1_chr19_16532287_ENST00000602009_length(amino acids)=325AA_BP=
MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT
PGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQK
AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AKAP8L-EPS15L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneEPS15L1chr19:15529722chr19:16532287ENST0000024807082315_368264.0865.0DAB2
TgeneEPS15L1chr19:15529722chr19:16532287ENST0000045514082415_368264.0911.0DAB2
TgeneEPS15L1chr19:15529722chr19:16532287ENST0000053575382215_368264.0755.0DAB2
TgeneEPS15L1chr19:15529722chr19:16532287ENST0000059793781615_368264.0602.0DAB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKAP8L-EPS15L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKAP8L-EPS15L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0265554Ectrodactyly1ORPHANET