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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPA2-ARFIP1 (FusionGDB2 ID:HG27068TG27236)

Fusion Gene Summary for PPA2-ARFIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPA2-ARFIP1
Fusion gene ID: hg27068tg27236
HgeneTgene
Gene symbol

PPA2

ARFIP1

Gene ID

27068

27236

Gene nameinorganic pyrophosphatase 2ADP ribosylation factor interacting protein 1
SynonymsHSPC124|SCFAI|SCFI|SID6-306HSU52521
Cytomap('PPA2')('ARFIP1')

4q24

4q31.3

Type of geneprotein-codingprotein-coding
Descriptioninorganic pyrophosphatase 2, mitochondrialPPase 2pyrophosphatase (inorganic) 2pyrophosphatase SID6-306pyrophosphate phospho-hydrolase 2arfaptin-1
Modification date2020031320200313
UniProtAcc.

P53367

Ensembl transtripts involved in fusion geneENST00000310267, ENST00000341695, 
ENST00000348706, ENST00000357415, 
ENST00000380004, ENST00000509426, 
ENST00000354147, ENST00000432483, 
Fusion gene scores* DoF score10 X 9 X 7=63010 X 10 X 11=1100
# samples 1119
** MAII scorelog2(11/630*10)=-2.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1100*10)=-2.53343220008107
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPA2 [Title/Abstract] AND ARFIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPA2(106367539)-ARFIP1(153784757), # samples:1
PPA2(106367540)-ARFIP1(153784758), # samples:1
Anticipated loss of major functional domain due to fusion event.PPA2-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPA2-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPA2-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARFIP1

GO:0006886

intracellular protein transport

12606037

TgeneARFIP1

GO:0050708

regulation of protein secretion

12606037


check buttonFusion gene breakpoints across PPA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ARFIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4HB-01APPA2chr4

106367540

-ARFIP1chr4

153784758

+
ChimerDB4STADTCGA-HU-A4HBPPA2chr4

106367539

-ARFIP1chr4

153784757

+


Top

Fusion Gene ORF analysis for PPA2-ARFIP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000310267ENST00000511289PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-3UTRENST00000310267ENST00000511289PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-3UTRENST00000341695ENST00000511289PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-3UTRENST00000341695ENST00000511289PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-3UTRENST00000348706ENST00000511289PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-3UTRENST00000348706ENST00000511289PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-3UTRENST00000357415ENST00000511289PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-3UTRENST00000357415ENST00000511289PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-3UTRENST00000380004ENST00000511289PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-3UTRENST00000380004ENST00000511289PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000310267ENST00000353617PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000310267ENST00000353617PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000310267ENST00000356064PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000310267ENST00000356064PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000310267ENST00000405727PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000310267ENST00000405727PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000310267ENST00000429148PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000310267ENST00000429148PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000341695ENST00000353617PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000341695ENST00000353617PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000341695ENST00000356064PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000341695ENST00000356064PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000341695ENST00000405727PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000341695ENST00000405727PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000341695ENST00000429148PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000341695ENST00000429148PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000348706ENST00000353617PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000348706ENST00000353617PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000348706ENST00000356064PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000348706ENST00000356064PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000348706ENST00000405727PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000348706ENST00000405727PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000348706ENST00000429148PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000348706ENST00000429148PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000357415ENST00000353617PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000357415ENST00000353617PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000357415ENST00000356064PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000357415ENST00000356064PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000357415ENST00000405727PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000357415ENST00000405727PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000357415ENST00000429148PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000357415ENST00000429148PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000380004ENST00000353617PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000380004ENST00000353617PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000380004ENST00000356064PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000380004ENST00000356064PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000380004ENST00000405727PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000380004ENST00000405727PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5CDS-intronENST00000380004ENST00000429148PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5CDS-intronENST00000380004ENST00000429148PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5UTR-3CDSENST00000509426ENST00000451320PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5UTR-3CDSENST00000509426ENST00000451320PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5UTR-3UTRENST00000509426ENST00000511289PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5UTR-3UTRENST00000509426ENST00000511289PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5UTR-intronENST00000509426ENST00000353617PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5UTR-intronENST00000509426ENST00000353617PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5UTR-intronENST00000509426ENST00000356064PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5UTR-intronENST00000509426ENST00000356064PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5UTR-intronENST00000509426ENST00000405727PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5UTR-intronENST00000509426ENST00000405727PPA2chr4

106367539

-ARFIP1chr4

153784757

+
5UTR-intronENST00000509426ENST00000429148PPA2chr4

106367540

-ARFIP1chr4

153784758

+
5UTR-intronENST00000509426ENST00000429148PPA2chr4

106367539

-ARFIP1chr4

153784757

+
Frame-shiftENST00000310267ENST00000451320PPA2chr4

106367540

-ARFIP1chr4

153784758

+
Frame-shiftENST00000310267ENST00000451320PPA2chr4

106367539

-ARFIP1chr4

153784757

+
In-frameENST00000341695ENST00000451320PPA2chr4

106367540

-ARFIP1chr4

153784758

+
In-frameENST00000341695ENST00000451320PPA2chr4

106367539

-ARFIP1chr4

153784757

+
In-frameENST00000348706ENST00000451320PPA2chr4

106367540

-ARFIP1chr4

153784758

+
In-frameENST00000348706ENST00000451320PPA2chr4

106367539

-ARFIP1chr4

153784757

+
In-frameENST00000357415ENST00000451320PPA2chr4

106367540

-ARFIP1chr4

153784758

+
In-frameENST00000357415ENST00000451320PPA2chr4

106367539

-ARFIP1chr4

153784757

+
In-frameENST00000380004ENST00000451320PPA2chr4

106367540

-ARFIP1chr4

153784758

+
In-frameENST00000380004ENST00000451320PPA2chr4

106367539

-ARFIP1chr4

153784757

+
intron-3CDSENST00000354147ENST00000451320PPA2chr4

106367540

-ARFIP1chr4

153784758

+
intron-3CDSENST00000354147ENST00000451320PPA2chr4

106367539

-ARFIP1chr4

153784757

+
intron-3CDSENST00000432483ENST00000451320PPA2chr4

106367540

-ARFIP1chr4

153784758

+
intron-3CDSENST00000432483ENST00000451320PPA2chr4

106367539

-ARFIP1chr4

153784757

+
intron-3UTRENST00000354147ENST00000511289PPA2chr4

106367540

-ARFIP1chr4

153784758

+
intron-3UTRENST00000354147ENST00000511289PPA2chr4

106367539

-ARFIP1chr4

153784757

+
intron-3UTRENST00000432483ENST00000511289PPA2chr4

106367540

-ARFIP1chr4

153784758

+
intron-3UTRENST00000432483ENST00000511289PPA2chr4

106367539

-ARFIP1chr4

153784757

+
intron-intronENST00000354147ENST00000353617PPA2chr4

106367540

-ARFIP1chr4

153784758

+
intron-intronENST00000354147ENST00000353617PPA2chr4

106367539

-ARFIP1chr4

153784757

+
intron-intronENST00000354147ENST00000356064PPA2chr4

106367540

-ARFIP1chr4

153784758

+
intron-intronENST00000354147ENST00000356064PPA2chr4

106367539

-ARFIP1chr4

153784757

+
intron-intronENST00000354147ENST00000405727PPA2chr4

106367540

-ARFIP1chr4

153784758

+
intron-intronENST00000354147ENST00000405727PPA2chr4

106367539

-ARFIP1chr4

153784757

+
intron-intronENST00000354147ENST00000429148PPA2chr4

106367540

-ARFIP1chr4

153784758

+
intron-intronENST00000354147ENST00000429148PPA2chr4

106367539

-ARFIP1chr4

153784757

+
intron-intronENST00000432483ENST00000353617PPA2chr4

106367540

-ARFIP1chr4

153784758

+
intron-intronENST00000432483ENST00000353617PPA2chr4

106367539

-ARFIP1chr4

153784757

+
intron-intronENST00000432483ENST00000356064PPA2chr4

106367540

-ARFIP1chr4

153784758

+
intron-intronENST00000432483ENST00000356064PPA2chr4

106367539

-ARFIP1chr4

153784757

+
intron-intronENST00000432483ENST00000405727PPA2chr4

106367540

-ARFIP1chr4

153784758

+
intron-intronENST00000432483ENST00000405727PPA2chr4

106367539

-ARFIP1chr4

153784757

+
intron-intronENST00000432483ENST00000429148PPA2chr4

106367540

-ARFIP1chr4

153784758

+
intron-intronENST00000432483ENST00000429148PPA2chr4

106367539

-ARFIP1chr4

153784757

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341695PPA2chr4106367539-ENST00000451320ARFIP1chr4153784757+3639472311500489
ENST00000348706PPA2chr4106367539-ENST00000451320ARFIP1chr4153784757+3622455141483489
ENST00000380004PPA2chr4106367539-ENST00000451320ARFIP1chr4153784757+3568401141429471
ENST00000357415PPA2chr4106367539-ENST00000451320ARFIP1chr4153784757+3667500141528504
ENST00000341695PPA2chr4106367540-ENST00000451320ARFIP1chr4153784758+3639472311500489
ENST00000348706PPA2chr4106367540-ENST00000451320ARFIP1chr4153784758+3622455141483489
ENST00000380004PPA2chr4106367540-ENST00000451320ARFIP1chr4153784758+3568401141429471
ENST00000357415PPA2chr4106367540-ENST00000451320ARFIP1chr4153784758+3667500141528504

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341695ENST00000451320PPA2chr4106367539-ARFIP1chr4153784757+7.57E-050.9999243
ENST00000348706ENST00000451320PPA2chr4106367539-ARFIP1chr4153784757+7.44E-050.9999256
ENST00000380004ENST00000451320PPA2chr4106367539-ARFIP1chr4153784757+5.26E-050.9999474
ENST00000357415ENST00000451320PPA2chr4106367539-ARFIP1chr4153784757+8.31E-050.9999169
ENST00000341695ENST00000451320PPA2chr4106367540-ARFIP1chr4153784758+7.57E-050.9999243
ENST00000348706ENST00000451320PPA2chr4106367540-ARFIP1chr4153784758+7.44E-050.9999256
ENST00000380004ENST00000451320PPA2chr4106367540-ARFIP1chr4153784758+5.26E-050.9999474
ENST00000357415ENST00000451320PPA2chr4106367540-ARFIP1chr4153784758+8.31E-050.9999169

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Fusion Genomic Features for PPA2-ARFIP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPA2chr4106367539-ARFIP1chr4153784757+3.66E-081
PPA2chr4106367539-ARFIP1chr4153784757+3.66E-081
PPA2chr4106367539-ARFIP1chr4153784757+3.66E-081
PPA2chr4106367539-ARFIP1chr4153784757+3.66E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPA2-ARFIP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:106367539/chr4:153784757)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARFIP1

P53367

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:9038142, PubMed:22981988). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARFIP1chr4:106367539chr4:153784757ENST0000035361719153_35331374.0DomainAH
TgeneARFIP1chr4:106367539chr4:153784757ENST0000035606418153_35331342.0DomainAH
TgeneARFIP1chr4:106367539chr4:153784757ENST0000040572718153_35331342.0DomainAH
TgeneARFIP1chr4:106367539chr4:153784757ENST0000045132019153_35331374.0DomainAH
TgeneARFIP1chr4:106367540chr4:153784758ENST0000035361719153_35331374.0DomainAH
TgeneARFIP1chr4:106367540chr4:153784758ENST0000035606418153_35331342.0DomainAH
TgeneARFIP1chr4:106367540chr4:153784758ENST0000040572718153_35331342.0DomainAH
TgeneARFIP1chr4:106367540chr4:153784758ENST0000045132019153_35331374.0DomainAH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PPA2-ARFIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67275_67275_1_PPA2-ARFIP1_PPA2_chr4_106367539_ENST00000341695_ARFIP1_chr4_153784757_ENST00000451320_length(transcript)=3639nt_BP=472nt
CCGCGCGCACAGCAGGACCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTT
GGGGACCAGTGCAGGGACCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCT
CTTCTTTAAGAATGTAACTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGAAAATGGCATTCCTAT
GAAGAAAGCACGAAATGATGAATATGAGAATCTGTTTAATATGATTGTAGAAATACCTCGGTGGACAAATGCTAAAATGGAGATTGCCAC
CAAGGAGCCAATGAATCCCATTAAACAATATGTAAAGGATGGAAAGCTACGCTATGTGGCGAATATCTTCCCTTACAAGGGTTATATATG
GAATTATGGTACCCTCCCTCAGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAATTACATCTCATGGCTTTGA
CAATACCAAAGAGGGTGTTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTATGTCTCCTAGCAGGGTTGC
AGCTAGTCGACTGGCTCAGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAAGTGGACCAGTTATTCTAGC
AGATGAAATTAAAAATCCTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGTGTACTCGACAGATTATCTC
TGAGAAGCTAGGCCGTGGCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATAACAAGAAAAAATATGAAAA
TATTTTAAAACTGGCTCAAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAGATGCATTTGCTGACCTGAG
TTTGAAGTCACTAGAACTTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATGGAGAGACTCTTCTTGGGGC
CATTAATTTTTTCATTGCTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAATGACTGTGAAACAGTATGAAAGTGCCAG
GATTGAATATGATGCATATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGCCAAAGATTGAGCAGTCACA
GCATCTCTTCCAAGCACATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTCTAGAAGAAAATAAGGTTAA
AGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACACTTAAACA
GTTCCATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAAAAAGAAAGTCG
CGTTGTTATATTTCTAAACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTGATTCTTGCACA
AACAGCTTTAATTTTTCCCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTATAATCTGAACAC
AATAATTTTCCTTTTTGAGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGAGATTTGCACTG
ACAAGATAAAAATTCAAGGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTTGTATCAACATC
AGATATTTTATATGTGAATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGCAGAGTAAAGTT
ATATGGTGTTCCTGCAGCGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTTTTTAAAAATGA
ATCTGTACCACTGTAATTTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAGCTTATGAATTT
GCTTCACCCGAAGTCATTGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTTTTTTGACAGGT
GGACGTGGGAATGGAAATTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCATTTTGATAGAAG
TGAATACATAGACAGCTTTTATTGACTTCCATATGTAACAATACCGTTTAAGCCTTAAATCACAGATATGTGCCTTCTCAGATACAGTAA
TTCTTGTTCAACCAATGTACAAAATCCATAAAGAAACCCCTGTTGGATAATGTTTGATGTGTCTATTCCTTCCATGGAATGGAGCACTAT
GTATGAATGTTGGGTTTCTTTGTACTTGTTAAGCCACATTTGAGGTTTATGGTAAAAATCATCTTTTGAGTTTGCTCTTTGGTTTTTCTT
CATTCCTTTTGAGGATTGGGAAAACAGAAAGATTCTTTGATTTGGGTAATGAAGAGGTAATTTGGGACAGTGTGGTGGTACCAGGAAGAA
AGAGGATTGGAAAGGCCAGTACTGTTTTAGTTGCTCGGCACTGTTGGTTTTGTTTTAATGTGGTTGCCCTGTCCACTACATGGTTCTATC
AGTAGTGTAATCCATTTTCAATGTAAAGCTCTTTTAGTTTTTGTCATAGACATAAATTAATATTTTGAGAGGCATCCCTCACCTGTTCAT
TTCTTCTGTGTTGAAATGAAGTACTTAAAATTACCGTTATACATGAACTTTGTGGACTGTAAGATTTGTTATATATGTTCAAATGCCTTT
TAGCTGGCTTTTTAATTAATATGCCTGTTTTGAGTGCTTAATACAATGTAATGTGATTGTAAATCATACCTATTTTAAATCATTCCTTCC
TGTATATTTGTACTCAGAGAGCCTTATTTTATTCTTCCAGCAGAATTACTACTTGTGATAGTTCATTTACATTCCCCAGAATGTGCCTCT
AGTGTGAATTTTGTATTCTTATTAAACGTGTTTGCTGCAGTAAATCGTTTCTCTGGACCTTCATAGTTTAAGAAGTAACTATTTGGAAAT
TCTGAAGACACATAATTTGCGTTTTCTGAACCTTAAAAAAAAAGGTACTTCTGTCACTTATAATTGTTTTAGCTCAGTAAGCTATTTTTT
TTCAATGTGAATCTCTTTTGAGAGCTGAACATGTCCATTCTTAACCACATTTCAATAACAGTTACTGTAGCTAAGGAGCTAAATAGTTTC
ATGGATTAATTTTTTTCAGAATAAATTTAAAATATCCATGATTCTGATAGTGGGCACATGACCAAAAGAAAAAAGTAAATCAATATATTT
AGCCAATGGTACATTTACTTTGTTAGGAATGTAATTTATGTTCATTATAGAAAAGAATTAGAAGAAAATTTCAAGTAATAGAAGATAAGT

>67275_67275_1_PPA2-ARFIP1_PPA2_chr4_106367539_ENST00000341695_ARFIP1_chr4_153784757_ENST00000451320_length(amino acids)=489AA_BP=147
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYEN
LFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQDLKHSLPSGLGLSETQITSHGFDNTKEGVIEAG
AFQGSPAPPLPSVMSPSRVAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTV
DLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNT
LVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFH

--------------------------------------------------------------
>67275_67275_2_PPA2-ARFIP1_PPA2_chr4_106367539_ENST00000348706_ARFIP1_chr4_153784757_ENST00000451320_length(transcript)=3622nt_BP=455nt
CCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTGGGGACCAGTGCAGGGA
CCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAA
CTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGAAAATGGCATTCCTATGAAGAAAGCACGAAATG
ATGAATATGAGAATCTGTTTAATATGATTGTAGAAATACCTCGGTGGACAAATGCTAAAATGGAGATTGCCACCAAGGAGCCAATGAATC
CCATTAAACAATATGTAAAGGATGGAAAGCTACGCTATGTGGCGAATATCTTCCCTTACAAGGGTTATATATGGAATTATGGTACCCTCC
CTCAGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAATTACATCTCATGGCTTTGACAATACCAAAGAGGGTG
TTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTATGTCTCCTAGCAGGGTTGCAGCTAGTCGACTGGCTC
AGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAAGTGGACCAGTTATTCTAGCAGATGAAATTAAAAATC
CTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGTGTACTCGACAGATTATCTCTGAGAAGCTAGGCCGTG
GCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATAACAAGAAAAAATATGAAAATATTTTAAAACTGGCTC
AAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAGATGCATTTGCTGACCTGAGTTTGAAGTCACTAGAAC
TTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATGGAGAGACTCTTCTTGGGGCCATTAATTTTTTCATTG
CTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAATGACTGTGAAACAGTATGAAAGTGCCAGGATTGAATATGATGCAT
ATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGCCAAAGATTGAGCAGTCACAGCATCTCTTCCAAGCAC
ATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTCTAGAAGAAAATAAGGTTAAAGTATTGCACAATCAGC
TGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACACTTAAACAGTTCCATATCAAATTGA
AAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAAAAAGAAAGTCGCGTTGTTATATTTCTAA
ACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTGATTCTTGCACAAACAGCTTTAATTTTTC
CCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTATAATCTGAACACAATAATTTTCCTTTTTG
AGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGAGATTTGCACTGACAAGATAAAAATTCAA
GGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTTGTATCAACATCAGATATTTTATATGTGA
ATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGCAGAGTAAAGTTATATGGTGTTCCTGCAG
CGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTTTTTAAAAATGAATCTGTACCACTGTAAT
TTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAGCTTATGAATTTGCTTCACCCGAAGTCAT
TGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTTTTTTGACAGGTGGACGTGGGAATGGAAA
TTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCATTTTGATAGAAGTGAATACATAGACAGCT
TTTATTGACTTCCATATGTAACAATACCGTTTAAGCCTTAAATCACAGATATGTGCCTTCTCAGATACAGTAATTCTTGTTCAACCAATG
TACAAAATCCATAAAGAAACCCCTGTTGGATAATGTTTGATGTGTCTATTCCTTCCATGGAATGGAGCACTATGTATGAATGTTGGGTTT
CTTTGTACTTGTTAAGCCACATTTGAGGTTTATGGTAAAAATCATCTTTTGAGTTTGCTCTTTGGTTTTTCTTCATTCCTTTTGAGGATT
GGGAAAACAGAAAGATTCTTTGATTTGGGTAATGAAGAGGTAATTTGGGACAGTGTGGTGGTACCAGGAAGAAAGAGGATTGGAAAGGCC
AGTACTGTTTTAGTTGCTCGGCACTGTTGGTTTTGTTTTAATGTGGTTGCCCTGTCCACTACATGGTTCTATCAGTAGTGTAATCCATTT
TCAATGTAAAGCTCTTTTAGTTTTTGTCATAGACATAAATTAATATTTTGAGAGGCATCCCTCACCTGTTCATTTCTTCTGTGTTGAAAT
GAAGTACTTAAAATTACCGTTATACATGAACTTTGTGGACTGTAAGATTTGTTATATATGTTCAAATGCCTTTTAGCTGGCTTTTTAATT
AATATGCCTGTTTTGAGTGCTTAATACAATGTAATGTGATTGTAAATCATACCTATTTTAAATCATTCCTTCCTGTATATTTGTACTCAG
AGAGCCTTATTTTATTCTTCCAGCAGAATTACTACTTGTGATAGTTCATTTACATTCCCCAGAATGTGCCTCTAGTGTGAATTTTGTATT
CTTATTAAACGTGTTTGCTGCAGTAAATCGTTTCTCTGGACCTTCATAGTTTAAGAAGTAACTATTTGGAAATTCTGAAGACACATAATT
TGCGTTTTCTGAACCTTAAAAAAAAAGGTACTTCTGTCACTTATAATTGTTTTAGCTCAGTAAGCTATTTTTTTTCAATGTGAATCTCTT
TTGAGAGCTGAACATGTCCATTCTTAACCACATTTCAATAACAGTTACTGTAGCTAAGGAGCTAAATAGTTTCATGGATTAATTTTTTTC
AGAATAAATTTAAAATATCCATGATTCTGATAGTGGGCACATGACCAAAAGAAAAAAGTAAATCAATATATTTAGCCAATGGTACATTTA
CTTTGTTAGGAATGTAATTTATGTTCATTATAGAAAAGAATTAGAAGAAAATTTCAAGTAATAGAAGATAAGTACCTTCCCAAGTGAATA

>67275_67275_2_PPA2-ARFIP1_PPA2_chr4_106367539_ENST00000348706_ARFIP1_chr4_153784757_ENST00000451320_length(amino acids)=489AA_BP=147
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYEN
LFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQDLKHSLPSGLGLSETQITSHGFDNTKEGVIEAG
AFQGSPAPPLPSVMSPSRVAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTV
DLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNT
LVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFH

--------------------------------------------------------------
>67275_67275_3_PPA2-ARFIP1_PPA2_chr4_106367539_ENST00000357415_ARFIP1_chr4_153784757_ENST00000451320_length(transcript)=3667nt_BP=500nt
CCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTGGGGACCAGTGCAGGGA
CCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAA
CTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGACACTGAGGCTCAAGGCATTTTTATAGACTTGT
CTAAGATCTGGGAAAATGGCATTCCTATGAAGAAAGCACGAAATGATGAATATGAGAATCTGTTTAATATGATTGTAGAAATACCTCGGT
GGACAAATGCTAAAATGGAGATTGCCACCAAGGAGCCAATGAATCCCATTAAACAATATGTAAAGGATGGAAAGCTACGCTATGTGGCGA
ATATCTTCCCTTACAAGGGTTATATATGGAATTATGGTACCCTCCCTCAGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAG
AAACCCAAATTACATCTCATGGCTTTGACAATACCAAAGAGGGTGTTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGC
CATCTGTTATGTCTCCTAGCAGGGTTGCAGCTAGTCGACTGGCTCAGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACAC
AGACAAAAAGTGGACCAGTTATTCTAGCAGATGAAATTAAAAATCCTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACA
CCTATAAGTGTACTCGACAGATTATCTCTGAGAAGCTAGGCCGTGGCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATAT
TAAGGGATAACAAGAAAAAATATGAAAATATTTTAAAACTGGCTCAAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGC
AACTTGGAGATGCATTTGCTGACCTGAGTTTGAAGTCACTAGAACTTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGG
CTAAAAATGGAGAGACTCTTCTTGGGGCCATTAATTTTTTCATTGCTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAA
TGACTGTGAAACAGTATGAAAGTGCCAGGATTGAATATGATGCATATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAA
ACACTCTGCCAAAGATTGAGCAGTCACAGCATCTCTTCCAAGCACATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAAT
TGAAATTTCTAGAAGAAAATAAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATC
AGAAGCAGCTTGAACAGACACTTAAACAGTTCCATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAA
ATCACAGCGGAAAATAAAAAGAAAGTCGCGTTGTTATATTTCTAAACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGG
TGACAAGCATTATAGTGATTCTTGCACAAACAGCTTTAATTTTTCCCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAAT
GTAAACATAGTTTCTATAATCTGAACACAATAATTTTCCTTTTTGAGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTT
TGAAAACATCTAATAGAGATTTGCACTGACAAGATAAAAATTCAAGGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAG
GGAGGTTTACATGATTTGTATCAACATCAGATATTTTATATGTGAATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAA
AAAAGAAACTATTTTGCAGAGTAAAGTTATATGGTGTTCCTGCAGCGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGA
GTTGTGGCAAATACCTTTTTAAAAATGAATCTGTACCACTGTAATTTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATT
TCTGTGAGGCTTTTAAGCTTATGAATTTGCTTCACCCGAAGTCATTGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTG
CTTAAGAGAATTTTTTTTTTTGACAGGTGGACGTGGGAATGGAAATTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGT
TTTTGGGTCAGTTCCATTTTGATAGAAGTGAATACATAGACAGCTTTTATTGACTTCCATATGTAACAATACCGTTTAAGCCTTAAATCA
CAGATATGTGCCTTCTCAGATACAGTAATTCTTGTTCAACCAATGTACAAAATCCATAAAGAAACCCCTGTTGGATAATGTTTGATGTGT
CTATTCCTTCCATGGAATGGAGCACTATGTATGAATGTTGGGTTTCTTTGTACTTGTTAAGCCACATTTGAGGTTTATGGTAAAAATCAT
CTTTTGAGTTTGCTCTTTGGTTTTTCTTCATTCCTTTTGAGGATTGGGAAAACAGAAAGATTCTTTGATTTGGGTAATGAAGAGGTAATT
TGGGACAGTGTGGTGGTACCAGGAAGAAAGAGGATTGGAAAGGCCAGTACTGTTTTAGTTGCTCGGCACTGTTGGTTTTGTTTTAATGTG
GTTGCCCTGTCCACTACATGGTTCTATCAGTAGTGTAATCCATTTTCAATGTAAAGCTCTTTTAGTTTTTGTCATAGACATAAATTAATA
TTTTGAGAGGCATCCCTCACCTGTTCATTTCTTCTGTGTTGAAATGAAGTACTTAAAATTACCGTTATACATGAACTTTGTGGACTGTAA
GATTTGTTATATATGTTCAAATGCCTTTTAGCTGGCTTTTTAATTAATATGCCTGTTTTGAGTGCTTAATACAATGTAATGTGATTGTAA
ATCATACCTATTTTAAATCATTCCTTCCTGTATATTTGTACTCAGAGAGCCTTATTTTATTCTTCCAGCAGAATTACTACTTGTGATAGT
TCATTTACATTCCCCAGAATGTGCCTCTAGTGTGAATTTTGTATTCTTATTAAACGTGTTTGCTGCAGTAAATCGTTTCTCTGGACCTTC
ATAGTTTAAGAAGTAACTATTTGGAAATTCTGAAGACACATAATTTGCGTTTTCTGAACCTTAAAAAAAAAGGTACTTCTGTCACTTATA
ATTGTTTTAGCTCAGTAAGCTATTTTTTTTCAATGTGAATCTCTTTTGAGAGCTGAACATGTCCATTCTTAACCACATTTCAATAACAGT
TACTGTAGCTAAGGAGCTAAATAGTTTCATGGATTAATTTTTTTCAGAATAAATTTAAAATATCCATGATTCTGATAGTGGGCACATGAC
CAAAAGAAAAAAGTAAATCAATATATTTAGCCAATGGTACATTTACTTTGTTAGGAATGTAATTTATGTTCATTATAGAAAAGAATTAGA

>67275_67275_3_PPA2-ARFIP1_PPA2_chr4_106367539_ENST00000357415_ARFIP1_chr4_153784757_ENST00000451320_length(amino acids)=504AA_BP=162
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEDTEAQGIFIDLSKIWE
NGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQDLKHSLPSGLGLSETQIT
SHGFDNTKEGVIEAGAFQGSPAPPLPSVMSPSRVAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCT
RQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGE
TLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLE

--------------------------------------------------------------
>67275_67275_4_PPA2-ARFIP1_PPA2_chr4_106367539_ENST00000380004_ARFIP1_chr4_153784757_ENST00000451320_length(transcript)=3568nt_BP=401nt
CCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTGGGGACCAGTGCAGGGA
CCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAA
CTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGAAAATGGCATTCCTATGAAGAAAGCACGAAATG
ATGAATATGAGATTGCCACCAAGGAGCCAATGAATCCCATTAAACAATATGTAAAGGATGGAAAGCTACGCTATGTGGCGAATATCTTCC
CTTACAAGGGTTATATATGGAATTATGGTACCCTCCCTCAGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAA
TTACATCTCATGGCTTTGACAATACCAAAGAGGGTGTTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTA
TGTCTCCTAGCAGGGTTGCAGCTAGTCGACTGGCTCAGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAA
GTGGACCAGTTATTCTAGCAGATGAAATTAAAAATCCTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGT
GTACTCGACAGATTATCTCTGAGAAGCTAGGCCGTGGCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATA
ACAAGAAAAAATATGAAAATATTTTAAAACTGGCTCAAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAG
ATGCATTTGCTGACCTGAGTTTGAAGTCACTAGAACTTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATG
GAGAGACTCTTCTTGGGGCCATTAATTTTTTCATTGCTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAATGACTGTGA
AACAGTATGAAAGTGCCAGGATTGAATATGATGCATATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGC
CAAAGATTGAGCAGTCACAGCATCTCTTCCAAGCACATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTC
TAGAAGAAAATAAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGC
TTGAACAGACACTTAAACAGTTCCATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCG
GAAAATAAAAAGAAAGTCGCGTTGTTATATTTCTAAACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCA
TTATAGTGATTCTTGCACAAACAGCTTTAATTTTTCCCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATA
GTTTCTATAATCTGAACACAATAATTTTCCTTTTTGAGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACAT
CTAATAGAGATTTGCACTGACAAGATAAAAATTCAAGGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTA
CATGATTTGTATCAACATCAGATATTTTATATGTGAATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAAC
TATTTTGCAGAGTAAAGTTATATGGTGTTCCTGCAGCGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCA
AATACCTTTTTAAAAATGAATCTGTACCACTGTAATTTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGG
CTTTTAAGCTTATGAATTTGCTTCACCCGAAGTCATTGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGA
ATTTTTTTTTTTGACAGGTGGACGTGGGAATGGAAATTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTC
AGTTCCATTTTGATAGAAGTGAATACATAGACAGCTTTTATTGACTTCCATATGTAACAATACCGTTTAAGCCTTAAATCACAGATATGT
GCCTTCTCAGATACAGTAATTCTTGTTCAACCAATGTACAAAATCCATAAAGAAACCCCTGTTGGATAATGTTTGATGTGTCTATTCCTT
CCATGGAATGGAGCACTATGTATGAATGTTGGGTTTCTTTGTACTTGTTAAGCCACATTTGAGGTTTATGGTAAAAATCATCTTTTGAGT
TTGCTCTTTGGTTTTTCTTCATTCCTTTTGAGGATTGGGAAAACAGAAAGATTCTTTGATTTGGGTAATGAAGAGGTAATTTGGGACAGT
GTGGTGGTACCAGGAAGAAAGAGGATTGGAAAGGCCAGTACTGTTTTAGTTGCTCGGCACTGTTGGTTTTGTTTTAATGTGGTTGCCCTG
TCCACTACATGGTTCTATCAGTAGTGTAATCCATTTTCAATGTAAAGCTCTTTTAGTTTTTGTCATAGACATAAATTAATATTTTGAGAG
GCATCCCTCACCTGTTCATTTCTTCTGTGTTGAAATGAAGTACTTAAAATTACCGTTATACATGAACTTTGTGGACTGTAAGATTTGTTA
TATATGTTCAAATGCCTTTTAGCTGGCTTTTTAATTAATATGCCTGTTTTGAGTGCTTAATACAATGTAATGTGATTGTAAATCATACCT
ATTTTAAATCATTCCTTCCTGTATATTTGTACTCAGAGAGCCTTATTTTATTCTTCCAGCAGAATTACTACTTGTGATAGTTCATTTACA
TTCCCCAGAATGTGCCTCTAGTGTGAATTTTGTATTCTTATTAAACGTGTTTGCTGCAGTAAATCGTTTCTCTGGACCTTCATAGTTTAA
GAAGTAACTATTTGGAAATTCTGAAGACACATAATTTGCGTTTTCTGAACCTTAAAAAAAAAGGTACTTCTGTCACTTATAATTGTTTTA
GCTCAGTAAGCTATTTTTTTTCAATGTGAATCTCTTTTGAGAGCTGAACATGTCCATTCTTAACCACATTTCAATAACAGTTACTGTAGC
TAAGGAGCTAAATAGTTTCATGGATTAATTTTTTTCAGAATAAATTTAAAATATCCATGATTCTGATAGTGGGCACATGACCAAAAGAAA
AAAGTAAATCAATATATTTAGCCAATGGTACATTTACTTTGTTAGGAATGTAATTTATGTTCATTATAGAAAAGAATTAGAAGAAAATTT

>67275_67275_4_PPA2-ARFIP1_PPA2_chr4_106367539_ENST00000380004_ARFIP1_chr4_153784757_ENST00000451320_length(amino acids)=471AA_BP=129
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYEI
ATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQDLKHSLPSGLGLSETQITSHGFDNTKEGVIEAGAFQGSPAPPLPSVMSPSR
VAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKY
ENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYES
ARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTL

--------------------------------------------------------------
>67275_67275_5_PPA2-ARFIP1_PPA2_chr4_106367540_ENST00000341695_ARFIP1_chr4_153784758_ENST00000451320_length(transcript)=3639nt_BP=472nt
CCGCGCGCACAGCAGGACCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTT
GGGGACCAGTGCAGGGACCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCT
CTTCTTTAAGAATGTAACTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGAAAATGGCATTCCTAT
GAAGAAAGCACGAAATGATGAATATGAGAATCTGTTTAATATGATTGTAGAAATACCTCGGTGGACAAATGCTAAAATGGAGATTGCCAC
CAAGGAGCCAATGAATCCCATTAAACAATATGTAAAGGATGGAAAGCTACGCTATGTGGCGAATATCTTCCCTTACAAGGGTTATATATG
GAATTATGGTACCCTCCCTCAGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAATTACATCTCATGGCTTTGA
CAATACCAAAGAGGGTGTTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTATGTCTCCTAGCAGGGTTGC
AGCTAGTCGACTGGCTCAGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAAGTGGACCAGTTATTCTAGC
AGATGAAATTAAAAATCCTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGTGTACTCGACAGATTATCTC
TGAGAAGCTAGGCCGTGGCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATAACAAGAAAAAATATGAAAA
TATTTTAAAACTGGCTCAAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAGATGCATTTGCTGACCTGAG
TTTGAAGTCACTAGAACTTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATGGAGAGACTCTTCTTGGGGC
CATTAATTTTTTCATTGCTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAATGACTGTGAAACAGTATGAAAGTGCCAG
GATTGAATATGATGCATATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGCCAAAGATTGAGCAGTCACA
GCATCTCTTCCAAGCACATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTCTAGAAGAAAATAAGGTTAA
AGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACACTTAAACA
GTTCCATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAAAAAGAAAGTCG
CGTTGTTATATTTCTAAACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTGATTCTTGCACA
AACAGCTTTAATTTTTCCCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTATAATCTGAACAC
AATAATTTTCCTTTTTGAGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGAGATTTGCACTG
ACAAGATAAAAATTCAAGGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTTGTATCAACATC
AGATATTTTATATGTGAATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGCAGAGTAAAGTT
ATATGGTGTTCCTGCAGCGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTTTTTAAAAATGA
ATCTGTACCACTGTAATTTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAGCTTATGAATTT
GCTTCACCCGAAGTCATTGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTTTTTTGACAGGT
GGACGTGGGAATGGAAATTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCATTTTGATAGAAG
TGAATACATAGACAGCTTTTATTGACTTCCATATGTAACAATACCGTTTAAGCCTTAAATCACAGATATGTGCCTTCTCAGATACAGTAA
TTCTTGTTCAACCAATGTACAAAATCCATAAAGAAACCCCTGTTGGATAATGTTTGATGTGTCTATTCCTTCCATGGAATGGAGCACTAT
GTATGAATGTTGGGTTTCTTTGTACTTGTTAAGCCACATTTGAGGTTTATGGTAAAAATCATCTTTTGAGTTTGCTCTTTGGTTTTTCTT
CATTCCTTTTGAGGATTGGGAAAACAGAAAGATTCTTTGATTTGGGTAATGAAGAGGTAATTTGGGACAGTGTGGTGGTACCAGGAAGAA
AGAGGATTGGAAAGGCCAGTACTGTTTTAGTTGCTCGGCACTGTTGGTTTTGTTTTAATGTGGTTGCCCTGTCCACTACATGGTTCTATC
AGTAGTGTAATCCATTTTCAATGTAAAGCTCTTTTAGTTTTTGTCATAGACATAAATTAATATTTTGAGAGGCATCCCTCACCTGTTCAT
TTCTTCTGTGTTGAAATGAAGTACTTAAAATTACCGTTATACATGAACTTTGTGGACTGTAAGATTTGTTATATATGTTCAAATGCCTTT
TAGCTGGCTTTTTAATTAATATGCCTGTTTTGAGTGCTTAATACAATGTAATGTGATTGTAAATCATACCTATTTTAAATCATTCCTTCC
TGTATATTTGTACTCAGAGAGCCTTATTTTATTCTTCCAGCAGAATTACTACTTGTGATAGTTCATTTACATTCCCCAGAATGTGCCTCT
AGTGTGAATTTTGTATTCTTATTAAACGTGTTTGCTGCAGTAAATCGTTTCTCTGGACCTTCATAGTTTAAGAAGTAACTATTTGGAAAT
TCTGAAGACACATAATTTGCGTTTTCTGAACCTTAAAAAAAAAGGTACTTCTGTCACTTATAATTGTTTTAGCTCAGTAAGCTATTTTTT
TTCAATGTGAATCTCTTTTGAGAGCTGAACATGTCCATTCTTAACCACATTTCAATAACAGTTACTGTAGCTAAGGAGCTAAATAGTTTC
ATGGATTAATTTTTTTCAGAATAAATTTAAAATATCCATGATTCTGATAGTGGGCACATGACCAAAAGAAAAAAGTAAATCAATATATTT
AGCCAATGGTACATTTACTTTGTTAGGAATGTAATTTATGTTCATTATAGAAAAGAATTAGAAGAAAATTTCAAGTAATAGAAGATAAGT

>67275_67275_5_PPA2-ARFIP1_PPA2_chr4_106367540_ENST00000341695_ARFIP1_chr4_153784758_ENST00000451320_length(amino acids)=489AA_BP=147
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYEN
LFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQDLKHSLPSGLGLSETQITSHGFDNTKEGVIEAG
AFQGSPAPPLPSVMSPSRVAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTV
DLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNT
LVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFH

--------------------------------------------------------------
>67275_67275_6_PPA2-ARFIP1_PPA2_chr4_106367540_ENST00000348706_ARFIP1_chr4_153784758_ENST00000451320_length(transcript)=3622nt_BP=455nt
CCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTGGGGACCAGTGCAGGGA
CCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAA
CTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGAAAATGGCATTCCTATGAAGAAAGCACGAAATG
ATGAATATGAGAATCTGTTTAATATGATTGTAGAAATACCTCGGTGGACAAATGCTAAAATGGAGATTGCCACCAAGGAGCCAATGAATC
CCATTAAACAATATGTAAAGGATGGAAAGCTACGCTATGTGGCGAATATCTTCCCTTACAAGGGTTATATATGGAATTATGGTACCCTCC
CTCAGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAATTACATCTCATGGCTTTGACAATACCAAAGAGGGTG
TTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTATGTCTCCTAGCAGGGTTGCAGCTAGTCGACTGGCTC
AGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAAGTGGACCAGTTATTCTAGCAGATGAAATTAAAAATC
CTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGTGTACTCGACAGATTATCTCTGAGAAGCTAGGCCGTG
GCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATAACAAGAAAAAATATGAAAATATTTTAAAACTGGCTC
AAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAGATGCATTTGCTGACCTGAGTTTGAAGTCACTAGAAC
TTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATGGAGAGACTCTTCTTGGGGCCATTAATTTTTTCATTG
CTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAATGACTGTGAAACAGTATGAAAGTGCCAGGATTGAATATGATGCAT
ATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGCCAAAGATTGAGCAGTCACAGCATCTCTTCCAAGCAC
ATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTCTAGAAGAAAATAAGGTTAAAGTATTGCACAATCAGC
TGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACACTTAAACAGTTCCATATCAAATTGA
AAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAAAAAGAAAGTCGCGTTGTTATATTTCTAA
ACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTGATTCTTGCACAAACAGCTTTAATTTTTC
CCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTATAATCTGAACACAATAATTTTCCTTTTTG
AGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGAGATTTGCACTGACAAGATAAAAATTCAA
GGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTTGTATCAACATCAGATATTTTATATGTGA
ATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGCAGAGTAAAGTTATATGGTGTTCCTGCAG
CGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTTTTTAAAAATGAATCTGTACCACTGTAAT
TTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAGCTTATGAATTTGCTTCACCCGAAGTCAT
TGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTTTTTTGACAGGTGGACGTGGGAATGGAAA
TTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCATTTTGATAGAAGTGAATACATAGACAGCT
TTTATTGACTTCCATATGTAACAATACCGTTTAAGCCTTAAATCACAGATATGTGCCTTCTCAGATACAGTAATTCTTGTTCAACCAATG
TACAAAATCCATAAAGAAACCCCTGTTGGATAATGTTTGATGTGTCTATTCCTTCCATGGAATGGAGCACTATGTATGAATGTTGGGTTT
CTTTGTACTTGTTAAGCCACATTTGAGGTTTATGGTAAAAATCATCTTTTGAGTTTGCTCTTTGGTTTTTCTTCATTCCTTTTGAGGATT
GGGAAAACAGAAAGATTCTTTGATTTGGGTAATGAAGAGGTAATTTGGGACAGTGTGGTGGTACCAGGAAGAAAGAGGATTGGAAAGGCC
AGTACTGTTTTAGTTGCTCGGCACTGTTGGTTTTGTTTTAATGTGGTTGCCCTGTCCACTACATGGTTCTATCAGTAGTGTAATCCATTT
TCAATGTAAAGCTCTTTTAGTTTTTGTCATAGACATAAATTAATATTTTGAGAGGCATCCCTCACCTGTTCATTTCTTCTGTGTTGAAAT
GAAGTACTTAAAATTACCGTTATACATGAACTTTGTGGACTGTAAGATTTGTTATATATGTTCAAATGCCTTTTAGCTGGCTTTTTAATT
AATATGCCTGTTTTGAGTGCTTAATACAATGTAATGTGATTGTAAATCATACCTATTTTAAATCATTCCTTCCTGTATATTTGTACTCAG
AGAGCCTTATTTTATTCTTCCAGCAGAATTACTACTTGTGATAGTTCATTTACATTCCCCAGAATGTGCCTCTAGTGTGAATTTTGTATT
CTTATTAAACGTGTTTGCTGCAGTAAATCGTTTCTCTGGACCTTCATAGTTTAAGAAGTAACTATTTGGAAATTCTGAAGACACATAATT
TGCGTTTTCTGAACCTTAAAAAAAAAGGTACTTCTGTCACTTATAATTGTTTTAGCTCAGTAAGCTATTTTTTTTCAATGTGAATCTCTT
TTGAGAGCTGAACATGTCCATTCTTAACCACATTTCAATAACAGTTACTGTAGCTAAGGAGCTAAATAGTTTCATGGATTAATTTTTTTC
AGAATAAATTTAAAATATCCATGATTCTGATAGTGGGCACATGACCAAAAGAAAAAAGTAAATCAATATATTTAGCCAATGGTACATTTA
CTTTGTTAGGAATGTAATTTATGTTCATTATAGAAAAGAATTAGAAGAAAATTTCAAGTAATAGAAGATAAGTACCTTCCCAAGTGAATA

>67275_67275_6_PPA2-ARFIP1_PPA2_chr4_106367540_ENST00000348706_ARFIP1_chr4_153784758_ENST00000451320_length(amino acids)=489AA_BP=147
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYEN
LFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQDLKHSLPSGLGLSETQITSHGFDNTKEGVIEAG
AFQGSPAPPLPSVMSPSRVAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTV
DLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNT
LVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFH

--------------------------------------------------------------
>67275_67275_7_PPA2-ARFIP1_PPA2_chr4_106367540_ENST00000357415_ARFIP1_chr4_153784758_ENST00000451320_length(transcript)=3667nt_BP=500nt
CCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTGGGGACCAGTGCAGGGA
CCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAA
CTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGACACTGAGGCTCAAGGCATTTTTATAGACTTGT
CTAAGATCTGGGAAAATGGCATTCCTATGAAGAAAGCACGAAATGATGAATATGAGAATCTGTTTAATATGATTGTAGAAATACCTCGGT
GGACAAATGCTAAAATGGAGATTGCCACCAAGGAGCCAATGAATCCCATTAAACAATATGTAAAGGATGGAAAGCTACGCTATGTGGCGA
ATATCTTCCCTTACAAGGGTTATATATGGAATTATGGTACCCTCCCTCAGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAG
AAACCCAAATTACATCTCATGGCTTTGACAATACCAAAGAGGGTGTTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGC
CATCTGTTATGTCTCCTAGCAGGGTTGCAGCTAGTCGACTGGCTCAGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACAC
AGACAAAAAGTGGACCAGTTATTCTAGCAGATGAAATTAAAAATCCTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACA
CCTATAAGTGTACTCGACAGATTATCTCTGAGAAGCTAGGCCGTGGCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATAT
TAAGGGATAACAAGAAAAAATATGAAAATATTTTAAAACTGGCTCAAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGC
AACTTGGAGATGCATTTGCTGACCTGAGTTTGAAGTCACTAGAACTTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGG
CTAAAAATGGAGAGACTCTTCTTGGGGCCATTAATTTTTTCATTGCTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAA
TGACTGTGAAACAGTATGAAAGTGCCAGGATTGAATATGATGCATATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAA
ACACTCTGCCAAAGATTGAGCAGTCACAGCATCTCTTCCAAGCACATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAAT
TGAAATTTCTAGAAGAAAATAAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATC
AGAAGCAGCTTGAACAGACACTTAAACAGTTCCATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAA
ATCACAGCGGAAAATAAAAAGAAAGTCGCGTTGTTATATTTCTAAACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGG
TGACAAGCATTATAGTGATTCTTGCACAAACAGCTTTAATTTTTCCCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAAT
GTAAACATAGTTTCTATAATCTGAACACAATAATTTTCCTTTTTGAGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTT
TGAAAACATCTAATAGAGATTTGCACTGACAAGATAAAAATTCAAGGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAG
GGAGGTTTACATGATTTGTATCAACATCAGATATTTTATATGTGAATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAA
AAAAGAAACTATTTTGCAGAGTAAAGTTATATGGTGTTCCTGCAGCGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGA
GTTGTGGCAAATACCTTTTTAAAAATGAATCTGTACCACTGTAATTTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATT
TCTGTGAGGCTTTTAAGCTTATGAATTTGCTTCACCCGAAGTCATTGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTG
CTTAAGAGAATTTTTTTTTTTGACAGGTGGACGTGGGAATGGAAATTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGT
TTTTGGGTCAGTTCCATTTTGATAGAAGTGAATACATAGACAGCTTTTATTGACTTCCATATGTAACAATACCGTTTAAGCCTTAAATCA
CAGATATGTGCCTTCTCAGATACAGTAATTCTTGTTCAACCAATGTACAAAATCCATAAAGAAACCCCTGTTGGATAATGTTTGATGTGT
CTATTCCTTCCATGGAATGGAGCACTATGTATGAATGTTGGGTTTCTTTGTACTTGTTAAGCCACATTTGAGGTTTATGGTAAAAATCAT
CTTTTGAGTTTGCTCTTTGGTTTTTCTTCATTCCTTTTGAGGATTGGGAAAACAGAAAGATTCTTTGATTTGGGTAATGAAGAGGTAATT
TGGGACAGTGTGGTGGTACCAGGAAGAAAGAGGATTGGAAAGGCCAGTACTGTTTTAGTTGCTCGGCACTGTTGGTTTTGTTTTAATGTG
GTTGCCCTGTCCACTACATGGTTCTATCAGTAGTGTAATCCATTTTCAATGTAAAGCTCTTTTAGTTTTTGTCATAGACATAAATTAATA
TTTTGAGAGGCATCCCTCACCTGTTCATTTCTTCTGTGTTGAAATGAAGTACTTAAAATTACCGTTATACATGAACTTTGTGGACTGTAA
GATTTGTTATATATGTTCAAATGCCTTTTAGCTGGCTTTTTAATTAATATGCCTGTTTTGAGTGCTTAATACAATGTAATGTGATTGTAA
ATCATACCTATTTTAAATCATTCCTTCCTGTATATTTGTACTCAGAGAGCCTTATTTTATTCTTCCAGCAGAATTACTACTTGTGATAGT
TCATTTACATTCCCCAGAATGTGCCTCTAGTGTGAATTTTGTATTCTTATTAAACGTGTTTGCTGCAGTAAATCGTTTCTCTGGACCTTC
ATAGTTTAAGAAGTAACTATTTGGAAATTCTGAAGACACATAATTTGCGTTTTCTGAACCTTAAAAAAAAAGGTACTTCTGTCACTTATA
ATTGTTTTAGCTCAGTAAGCTATTTTTTTTCAATGTGAATCTCTTTTGAGAGCTGAACATGTCCATTCTTAACCACATTTCAATAACAGT
TACTGTAGCTAAGGAGCTAAATAGTTTCATGGATTAATTTTTTTCAGAATAAATTTAAAATATCCATGATTCTGATAGTGGGCACATGAC
CAAAAGAAAAAAGTAAATCAATATATTTAGCCAATGGTACATTTACTTTGTTAGGAATGTAATTTATGTTCATTATAGAAAAGAATTAGA

>67275_67275_7_PPA2-ARFIP1_PPA2_chr4_106367540_ENST00000357415_ARFIP1_chr4_153784758_ENST00000451320_length(amino acids)=504AA_BP=162
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEDTEAQGIFIDLSKIWE
NGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQDLKHSLPSGLGLSETQIT
SHGFDNTKEGVIEAGAFQGSPAPPLPSVMSPSRVAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCT
RQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGE
TLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLE

--------------------------------------------------------------
>67275_67275_8_PPA2-ARFIP1_PPA2_chr4_106367540_ENST00000380004_ARFIP1_chr4_153784758_ENST00000451320_length(transcript)=3568nt_BP=401nt
CCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTGGGGACCAGTGCAGGGA
CCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAA
CTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGAAAATGGCATTCCTATGAAGAAAGCACGAAATG
ATGAATATGAGATTGCCACCAAGGAGCCAATGAATCCCATTAAACAATATGTAAAGGATGGAAAGCTACGCTATGTGGCGAATATCTTCC
CTTACAAGGGTTATATATGGAATTATGGTACCCTCCCTCAGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAA
TTACATCTCATGGCTTTGACAATACCAAAGAGGGTGTTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTA
TGTCTCCTAGCAGGGTTGCAGCTAGTCGACTGGCTCAGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAA
GTGGACCAGTTATTCTAGCAGATGAAATTAAAAATCCTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGT
GTACTCGACAGATTATCTCTGAGAAGCTAGGCCGTGGCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATA
ACAAGAAAAAATATGAAAATATTTTAAAACTGGCTCAAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAG
ATGCATTTGCTGACCTGAGTTTGAAGTCACTAGAACTTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATG
GAGAGACTCTTCTTGGGGCCATTAATTTTTTCATTGCTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAATGACTGTGA
AACAGTATGAAAGTGCCAGGATTGAATATGATGCATATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGC
CAAAGATTGAGCAGTCACAGCATCTCTTCCAAGCACATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTC
TAGAAGAAAATAAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGC
TTGAACAGACACTTAAACAGTTCCATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCG
GAAAATAAAAAGAAAGTCGCGTTGTTATATTTCTAAACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCA
TTATAGTGATTCTTGCACAAACAGCTTTAATTTTTCCCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATA
GTTTCTATAATCTGAACACAATAATTTTCCTTTTTGAGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACAT
CTAATAGAGATTTGCACTGACAAGATAAAAATTCAAGGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTA
CATGATTTGTATCAACATCAGATATTTTATATGTGAATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAAC
TATTTTGCAGAGTAAAGTTATATGGTGTTCCTGCAGCGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCA
AATACCTTTTTAAAAATGAATCTGTACCACTGTAATTTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGG
CTTTTAAGCTTATGAATTTGCTTCACCCGAAGTCATTGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGA
ATTTTTTTTTTTGACAGGTGGACGTGGGAATGGAAATTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTC
AGTTCCATTTTGATAGAAGTGAATACATAGACAGCTTTTATTGACTTCCATATGTAACAATACCGTTTAAGCCTTAAATCACAGATATGT
GCCTTCTCAGATACAGTAATTCTTGTTCAACCAATGTACAAAATCCATAAAGAAACCCCTGTTGGATAATGTTTGATGTGTCTATTCCTT
CCATGGAATGGAGCACTATGTATGAATGTTGGGTTTCTTTGTACTTGTTAAGCCACATTTGAGGTTTATGGTAAAAATCATCTTTTGAGT
TTGCTCTTTGGTTTTTCTTCATTCCTTTTGAGGATTGGGAAAACAGAAAGATTCTTTGATTTGGGTAATGAAGAGGTAATTTGGGACAGT
GTGGTGGTACCAGGAAGAAAGAGGATTGGAAAGGCCAGTACTGTTTTAGTTGCTCGGCACTGTTGGTTTTGTTTTAATGTGGTTGCCCTG
TCCACTACATGGTTCTATCAGTAGTGTAATCCATTTTCAATGTAAAGCTCTTTTAGTTTTTGTCATAGACATAAATTAATATTTTGAGAG
GCATCCCTCACCTGTTCATTTCTTCTGTGTTGAAATGAAGTACTTAAAATTACCGTTATACATGAACTTTGTGGACTGTAAGATTTGTTA
TATATGTTCAAATGCCTTTTAGCTGGCTTTTTAATTAATATGCCTGTTTTGAGTGCTTAATACAATGTAATGTGATTGTAAATCATACCT
ATTTTAAATCATTCCTTCCTGTATATTTGTACTCAGAGAGCCTTATTTTATTCTTCCAGCAGAATTACTACTTGTGATAGTTCATTTACA
TTCCCCAGAATGTGCCTCTAGTGTGAATTTTGTATTCTTATTAAACGTGTTTGCTGCAGTAAATCGTTTCTCTGGACCTTCATAGTTTAA
GAAGTAACTATTTGGAAATTCTGAAGACACATAATTTGCGTTTTCTGAACCTTAAAAAAAAAGGTACTTCTGTCACTTATAATTGTTTTA
GCTCAGTAAGCTATTTTTTTTCAATGTGAATCTCTTTTGAGAGCTGAACATGTCCATTCTTAACCACATTTCAATAACAGTTACTGTAGC
TAAGGAGCTAAATAGTTTCATGGATTAATTTTTTTCAGAATAAATTTAAAATATCCATGATTCTGATAGTGGGCACATGACCAAAAGAAA
AAAGTAAATCAATATATTTAGCCAATGGTACATTTACTTTGTTAGGAATGTAATTTATGTTCATTATAGAAAAGAATTAGAAGAAAATTT

>67275_67275_8_PPA2-ARFIP1_PPA2_chr4_106367540_ENST00000380004_ARFIP1_chr4_153784758_ENST00000451320_length(amino acids)=471AA_BP=129
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYEI
ATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQDLKHSLPSGLGLSETQITSHGFDNTKEGVIEAGAFQGSPAPPLPSVMSPSR
VAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKY
ENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYES
ARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTL

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Fusion Gene PPI Analysis for PPA2-ARFIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPA2-ARFIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPA2-ARFIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPA2C4310663SUDDEN CARDIAC FAILURE, ALCOHOL-INDUCED2CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePPA2C4310664SUDDEN CARDIAC FAILURE, INFANTILE2CTD_human;GENOMICS_ENGLAND;UNIPROT