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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:B9D1-ALDH16A1 (FusionGDB2 ID:HG27077TG126133)

Fusion Gene Summary for B9D1-ALDH16A1

Fusion gene summary

Fusion gene information	Fusion gene name: B9D1-ALDH16A1
	Fusion gene ID: hg27077tg126133
		Hgene	Tgene
	Gene symbol	B9D1	ALDH16A1
	Gene ID	27077	126133
	Gene name	B9 domain containing 1	aldehyde dehydrogenase 16 family member A1
	Synonyms	B9\|EPPB9\|JBTS27\|MKS9\|MKSR-1\|MKSR1	-
	Cytomap	('B9D1')('ALDH16A1') 17p11.2	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	B9 domain-containing protein 1B9 protein domain 1MKS1-related protein 1endothelial precursor protein B9	aldehyde dehydrogenase family 16 member A1
	Modification date	20200313	20200313
	UniProtAcc	.	Q8IZ83
	Ensembl transtripts involved in fusion gene	ENST00000261499, ENST00000268841, ENST00000395615, ENST00000395616, ENST00000461069, ENST00000477478, ENST00000575403, ENST00000468679,
Fusion gene scores	* DoF score	5 X 5 X 5=125	9 X 10 X 7=630
	# samples	5	13
	** MAII score	log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/630*10)=-2.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: B9D1 [Title/Abstract] AND ALDH16A1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	B9D1(19263633)-ALDH16A1(49961743), # samples:2
Anticipated loss of major functional domain due to fusion event.	B9D1-ALDH16A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. B9D1-ALDH16A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across B9D1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ALDH16A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-E7-A7DV-01A	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+

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Fusion Gene ORF analysis for B9D1-ALDH16A1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000261499	ENST00000598015	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-3UTR	ENST00000268841	ENST00000598015	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-3UTR	ENST00000395615	ENST00000598015	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-3UTR	ENST00000395616	ENST00000598015	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-3UTR	ENST00000461069	ENST00000598015	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-3UTR	ENST00000477478	ENST00000598015	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-3UTR	ENST00000575403	ENST00000598015	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000261499	ENST00000433981	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000261499	ENST00000455361	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000261499	ENST00000540132	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000268841	ENST00000433981	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000268841	ENST00000455361	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000268841	ENST00000540132	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000395615	ENST00000433981	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000395615	ENST00000455361	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000395615	ENST00000540132	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000395616	ENST00000433981	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000395616	ENST00000455361	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000395616	ENST00000540132	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000461069	ENST00000433981	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000461069	ENST00000455361	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000461069	ENST00000540132	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000477478	ENST00000433981	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000477478	ENST00000455361	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000477478	ENST00000540132	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000575403	ENST00000433981	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000575403	ENST00000455361	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000575403	ENST00000540132	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
Frame-shift	ENST00000477478	ENST00000293350	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
Frame-shift	ENST00000575403	ENST00000293350	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
In-frame	ENST00000261499	ENST00000293350	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
In-frame	ENST00000268841	ENST00000293350	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
In-frame	ENST00000395615	ENST00000293350	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
In-frame	ENST00000395616	ENST00000293350	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
In-frame	ENST00000461069	ENST00000293350	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
intron-3CDS	ENST00000468679	ENST00000293350	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
intron-3UTR	ENST00000468679	ENST00000598015	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
intron-intron	ENST00000468679	ENST00000433981	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
intron-intron	ENST00000468679	ENST00000455361	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+
intron-intron	ENST00000468679	ENST00000540132	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000461069	B9D1	chr17	19263633	-	ENST00000293350	ALDH16A1	chr19	49961743	+	3077	177	45	2495	816
ENST00000395615	B9D1	chr17	19263633	-	ENST00000293350	ALDH16A1	chr19	49961743	+	3039	139	7	2457	816
ENST00000261499	B9D1	chr17	19263633	-	ENST00000293350	ALDH16A1	chr19	49961743	+	3176	276	144	2594	816
ENST00000395616	B9D1	chr17	19263633	-	ENST00000293350	ALDH16A1	chr19	49961743	+	3196	296	164	2614	816
ENST00000268841	B9D1	chr17	19263633	-	ENST00000293350	ALDH16A1	chr19	49961743	+	3132	232	100	2550	816

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000461069	ENST00000293350	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+	0.015219837	0.9847802
ENST00000395615	ENST00000293350	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+	0.015524163	0.9844758
ENST00000261499	ENST00000293350	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+	0.014386122	0.9856139
ENST00000395616	ENST00000293350	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+	0.01439599	0.98560405
ENST00000268841	ENST00000293350	B9D1	chr17	19263633	-	ALDH16A1	chr19	49961743	+	0.014228753	0.9857713

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Fusion Genomic Features for B9D1-ALDH16A1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
B9D1	chr17	19263632	-	ALDH16A1	chr19	49961742	+	9.45E-06	0.9999906
B9D1	chr17	19263632	-	ALDH16A1	chr19	49961742	+	9.45E-06	0.9999906

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for B9D1-ALDH16A1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:19263633/chr19:49961743)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ALDH16A1 Q8IZ83
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

B9D1

chr17:19263633

chr19:49961743

ENST00000261499

9_127

205.0

Domain

C2 B9-type

Hgene

B9D1

chr17:19263633

chr19:49961743

ENST00000268841

9_127

154.0

Domain

C2 B9-type

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Fusion Gene Sequence for B9D1-ALDH16A1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>8785_8785_1_B9D1-ALDH16A1_B9D1_chr17_19263633_ENST00000261499_ALDH16A1_chr19_49961743_ENST00000293350_length(transcript)=3176nt_BP=276nt
CGCGCACTCGCGTGGCCTTCGCGAAGGTGTCGCTGCCAAGAAACGTGTCCTGCGCGCTACGCCGTCTGTTTCTAGGGCAACGCCGGCGTC
TCTTAGCAACCGCGCGCGGCCTAGGTGGGTCCCCCCGGCACCCCCAGACCTGCCATGGCGACCGCGAGTCCTAGCGTCTTTCTACTCATG
GTCAACGGGCAGGTGGAGAGCGCCCAGTTTCCAGAGTATGATGACCTCTACTGCAAGTACTGCTTTGTGTACGGCCAGGACTGGGCCCCC
ACAGCGGCCTGGCTGGACACCCAGGACCGGTGCTTGGGCCACTATGTGAATGGGAAGTGGTTAAAGCCTGAACACAGAAATTCAGTGCCT
TGCCAGGATCCCATCACAGGAGAGAACTTGGCCAGTTGCCTGCAGGCACAGGCCGAGGATGTGGCTGCAGCCGTGGAGGCAGCCAGGATG
GCATTTAAGGGCTGGAGTGCGCACCCCGGCGTCGTCCGGGCCCAGCACCTGACCAGGCTGGCCGAGGTGATCCAGAAGCACCAGCGGCTG
CTGTGGACCCTGGAATCCCTGGTGACTGGGCGGGCTGTTCGAGAGGTTCGAGACGGGGACGTCCAGCTGGCCCAGCAGCTGCTCCACTAC
CATGCAATCCAGGCATCCACCCAGGAGGAGGCACTGGCAGGCTGGGAGCCCATGGGAGTAATTGGCCTCATCCTGCCACCCACATTCTCC
TTCCTTGAGATGATGTGGAGGATTTGCCCTGCCCTGGCTGTGGGCTGCACCGTGGTGGCCCTCGTGCCCCCGGCCTCCCCGGCGCCCCTC
CTCCTGGCCCAGCTGGCGGGGGAGCTGGGCCCCTTCCCGGGAATCCTGAATGTCCTCAGTGGCCCTGCGTCCCTGGTGCCCATCCTGGCC
TCCCAGCCTGGAATCCGGAAGGTGGCCTTCTGCGGAGCCCCGGAGGAAGGGCGTGCCCTTCGACGGAGCCTGGCGGGAGAGTGTGCGGAG
CTGGGCCTGGCGCTGGGGACGGAGTCGCTGCTGCTGCTGACGGACACGGCGGACGTAGACTCGGCCGTGGAGGGTGTCGTGGACGCCGCC
TGGTCCGACCGCGGCCCGGGTGGCCTCAGGCTCCTCATCCAGGAGTCTGTGTGGGATGAAGCCATGAGACGGCTGCAGGAGCGGATGGGG
CGGCTTCGGAGTGGCCGAGGGCTGGATGGGGCCGTGGACATGGGGGCCCGGGGGGCTGCCGCATGTGACCTGGTCCAGCGCTTTGTGCGT
GAGGCCCAGAGCCAGGGTGCACAGGTGTTCCAGGCTGGTGATGTGCCTTCGGAACGCCCATTCTATCCCCCAACCTTGGTCTCCAACCTG
CCCCCAGCCTCCCCATGTGCCCAGGTGGAGGTGCCGTGGCCTGTGGTCGTGGCCTCCCCCTTCCGCACAGCCAAGGAGGCACTGTTGGTG
GCCAACGGGACGCCCCGCGGGGGCAGCGCCAGTGTGTGGAGCGAGAGGCTGGGGCAGGCGCTGGAGCTGGGCTATGGGCTCCAGGTGGGC
ACTGTCTGGATCAACGCCCACGGCCTCAGAGACCCTTCGGTGCCCACAGGCGGCTGCAAGGAGAGTGGGTGTTCCTGGCACGGGGGCCCA
GACGGGCTGTATGAGTATCTGCGGCCCTCAGGGACCCCTGCCCGGCTGTCCTGCCTCTCCAAGAACCTGAACTATGACACCTTTGGCCTC
GCTGTTCCCTCAACCCTGCCGGCTGGGCCTGAAATAGGGCCCAGCCCAGCACCCCCCTATGGGCTCTTCGTTGGGGGCCGTTTCCAGGCT
CCTGGGGCCCGAAGCTCCAGGCCCATCCGGGATTCGTCTGGCAACCTCCATGGCTACGTGGCTGAGGGTGGAGCCAAGGACATCCGAGGT
GCTGTGGAGGCCGCTCACCAGGCTTTCCCTGGCTGGGCGGGCCAGTCCCCAGGAGCCCGGGCAGCCCTGCTGTGGGCCCTGGCGGCTGCA
CTGGAGCGCCGGAAGTCTACCCTGGCCTCGAGGCTGGAGAGGCAGGGAGCGGAGCTCAAGGCTGCGGAGGCGGAGGTGGAGCTGAGCGCA
AGACGACTTCGGGCGTGGGGGGCCCGGGTGCAGGCCCAAGGCCACACCCTGCAGGTAGCCGGGCTGAGAGGCCCTGTGCTGCGCCTGCGG
GAGCCGCTGGGTGTGCTGGCTGTGGTGTGTCCGGACGAGTGGCCCCTGCTTGCCTTCGTGTCCCTGCTGGCTCCCGCCCTGGCCTACGGC
AACACTGTGGTCATGGTGCCCAGTGCGGCCTGTCCTCTGCTGGCCCTGGAGGTCTGCCAGGACATGGCCACCGTGTTCCCAGCAGGCCTG
GCCAACGTGGTGACAGGAGACCGGGACCATCTGACCCGCTGCCTGGCCTTGCACCAAGACGTCCAGGCCATGTGGTATTTCGGATCAGCC
CAGGGTTCCCAGTTTGTCGAGTGGGCCTCGGCAGGAAACCTCAAACCGGTGTGGGCGAGCAGGGGCTGCCCGCGGGCCTGGGACCAGGAG
GCCGAGGGGGCAGGCCCAGAGCTGGGGCTGCGAGTGGCGCGGACCAAGGCCCTGTGGCTGCCTATGGGGGACTGATGCCTGAGCGCCACC
TACTGCATTTTGGACACCTCACACCAAGGGGAGATGCACCCCACAGACACCTGGGACTTTCCCCTTCTGGTTCCTGTGTCTCCCAATAAA
CTCTCTGACCAACCCTAGCTGTGCTTCTGCGAGAAGAAAGGGTGTAGCAACTTCTGGCAGATATGAGGCTTTTTTCTTTTTTTTTTTTTT
TTTTGAGACAACGTCTGGCTCTGTCACCCAGGCTGGAGCGCAGTGGCACAATCTCGGCCCACTGCAGCCTCGACCTCTGGGGCTCAAGGG
ATCCTCATGCCTCAGCCTCATATGTAGCTGGGGCCACAGACATGCACCACCACACCTGGCTCGAGGCCATTTTAGTTCTGAGGTTGAGCA
GCTCAGGAGCCGGCTCCAGCACGGTGCTGTGTTTGTGAAACAGAGAAAGGGGACCCCCGAGGACCCCAGACAGGGCCTTAGGACTCTCAT
ATCTTCTTGTCTTCTCCATCTGGTGGCTCTTGCTCTCTGGTTTTCTCTACCTTTTCATGGCCCCAGAATCCATATGCAGTAAAGGAACTC

>8785_8785_1_B9D1-ALDH16A1_B9D1_chr17_19263633_ENST00000261499_ALDH16A1_chr19_49961743_ENST00000293350_length(amino acids)=816AA_BP=44
MATASPSVFLLMVNGQVESAQFPEYDDLYCKYCFVYGQDWAPTAAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQA
EDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPM
GVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQPGIRKVAFCGAPEEGR
ALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARG
AAACDLVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLG
QALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAP
PYGLFVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQGAE
LKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEV
CQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAEGAGPELGLRVARTKAL

--------------------------------------------------------------
>8785_8785_2_B9D1-ALDH16A1_B9D1_chr17_19263633_ENST00000268841_ALDH16A1_chr19_49961743_ENST00000293350_length(transcript)=3132nt_BP=232nt
GTGTCCTGCGCGCTACGCCGTCTGTTTCTAGGGCAACGCCGGCGTCTCTTAGCAACCGCGCGCGGCCTAGGTGGGTCCCCCCGGCACCCC
CAGACCTGCCATGGCGACCGCGAGTCCTAGCGTCTTTCTACTCATGGTCAACGGGCAGGTGGAGAGCGCCCAGTTTCCAGAGTATGATGA
CCTCTACTGCAAGTACTGCTTTGTGTACGGCCAGGACTGGGCCCCCACAGCGGCCTGGCTGGACACCCAGGACCGGTGCTTGGGCCACTA
TGTGAATGGGAAGTGGTTAAAGCCTGAACACAGAAATTCAGTGCCTTGCCAGGATCCCATCACAGGAGAGAACTTGGCCAGTTGCCTGCA
GGCACAGGCCGAGGATGTGGCTGCAGCCGTGGAGGCAGCCAGGATGGCATTTAAGGGCTGGAGTGCGCACCCCGGCGTCGTCCGGGCCCA
GCACCTGACCAGGCTGGCCGAGGTGATCCAGAAGCACCAGCGGCTGCTGTGGACCCTGGAATCCCTGGTGACTGGGCGGGCTGTTCGAGA
GGTTCGAGACGGGGACGTCCAGCTGGCCCAGCAGCTGCTCCACTACCATGCAATCCAGGCATCCACCCAGGAGGAGGCACTGGCAGGCTG
GGAGCCCATGGGAGTAATTGGCCTCATCCTGCCACCCACATTCTCCTTCCTTGAGATGATGTGGAGGATTTGCCCTGCCCTGGCTGTGGG
CTGCACCGTGGTGGCCCTCGTGCCCCCGGCCTCCCCGGCGCCCCTCCTCCTGGCCCAGCTGGCGGGGGAGCTGGGCCCCTTCCCGGGAAT
CCTGAATGTCCTCAGTGGCCCTGCGTCCCTGGTGCCCATCCTGGCCTCCCAGCCTGGAATCCGGAAGGTGGCCTTCTGCGGAGCCCCGGA
GGAAGGGCGTGCCCTTCGACGGAGCCTGGCGGGAGAGTGTGCGGAGCTGGGCCTGGCGCTGGGGACGGAGTCGCTGCTGCTGCTGACGGA
CACGGCGGACGTAGACTCGGCCGTGGAGGGTGTCGTGGACGCCGCCTGGTCCGACCGCGGCCCGGGTGGCCTCAGGCTCCTCATCCAGGA
GTCTGTGTGGGATGAAGCCATGAGACGGCTGCAGGAGCGGATGGGGCGGCTTCGGAGTGGCCGAGGGCTGGATGGGGCCGTGGACATGGG
GGCCCGGGGGGCTGCCGCATGTGACCTGGTCCAGCGCTTTGTGCGTGAGGCCCAGAGCCAGGGTGCACAGGTGTTCCAGGCTGGTGATGT
GCCTTCGGAACGCCCATTCTATCCCCCAACCTTGGTCTCCAACCTGCCCCCAGCCTCCCCATGTGCCCAGGTGGAGGTGCCGTGGCCTGT
GGTCGTGGCCTCCCCCTTCCGCACAGCCAAGGAGGCACTGTTGGTGGCCAACGGGACGCCCCGCGGGGGCAGCGCCAGTGTGTGGAGCGA
GAGGCTGGGGCAGGCGCTGGAGCTGGGCTATGGGCTCCAGGTGGGCACTGTCTGGATCAACGCCCACGGCCTCAGAGACCCTTCGGTGCC
CACAGGCGGCTGCAAGGAGAGTGGGTGTTCCTGGCACGGGGGCCCAGACGGGCTGTATGAGTATCTGCGGCCCTCAGGGACCCCTGCCCG
GCTGTCCTGCCTCTCCAAGAACCTGAACTATGACACCTTTGGCCTCGCTGTTCCCTCAACCCTGCCGGCTGGGCCTGAAATAGGGCCCAG
CCCAGCACCCCCCTATGGGCTCTTCGTTGGGGGCCGTTTCCAGGCTCCTGGGGCCCGAAGCTCCAGGCCCATCCGGGATTCGTCTGGCAA
CCTCCATGGCTACGTGGCTGAGGGTGGAGCCAAGGACATCCGAGGTGCTGTGGAGGCCGCTCACCAGGCTTTCCCTGGCTGGGCGGGCCA
GTCCCCAGGAGCCCGGGCAGCCCTGCTGTGGGCCCTGGCGGCTGCACTGGAGCGCCGGAAGTCTACCCTGGCCTCGAGGCTGGAGAGGCA
GGGAGCGGAGCTCAAGGCTGCGGAGGCGGAGGTGGAGCTGAGCGCAAGACGACTTCGGGCGTGGGGGGCCCGGGTGCAGGCCCAAGGCCA
CACCCTGCAGGTAGCCGGGCTGAGAGGCCCTGTGCTGCGCCTGCGGGAGCCGCTGGGTGTGCTGGCTGTGGTGTGTCCGGACGAGTGGCC
CCTGCTTGCCTTCGTGTCCCTGCTGGCTCCCGCCCTGGCCTACGGCAACACTGTGGTCATGGTGCCCAGTGCGGCCTGTCCTCTGCTGGC
CCTGGAGGTCTGCCAGGACATGGCCACCGTGTTCCCAGCAGGCCTGGCCAACGTGGTGACAGGAGACCGGGACCATCTGACCCGCTGCCT
GGCCTTGCACCAAGACGTCCAGGCCATGTGGTATTTCGGATCAGCCCAGGGTTCCCAGTTTGTCGAGTGGGCCTCGGCAGGAAACCTCAA
ACCGGTGTGGGCGAGCAGGGGCTGCCCGCGGGCCTGGGACCAGGAGGCCGAGGGGGCAGGCCCAGAGCTGGGGCTGCGAGTGGCGCGGAC
CAAGGCCCTGTGGCTGCCTATGGGGGACTGATGCCTGAGCGCCACCTACTGCATTTTGGACACCTCACACCAAGGGGAGATGCACCCCAC
AGACACCTGGGACTTTCCCCTTCTGGTTCCTGTGTCTCCCAATAAACTCTCTGACCAACCCTAGCTGTGCTTCTGCGAGAAGAAAGGGTG
TAGCAACTTCTGGCAGATATGAGGCTTTTTTCTTTTTTTTTTTTTTTTTTGAGACAACGTCTGGCTCTGTCACCCAGGCTGGAGCGCAGT
GGCACAATCTCGGCCCACTGCAGCCTCGACCTCTGGGGCTCAAGGGATCCTCATGCCTCAGCCTCATATGTAGCTGGGGCCACAGACATG
CACCACCACACCTGGCTCGAGGCCATTTTAGTTCTGAGGTTGAGCAGCTCAGGAGCCGGCTCCAGCACGGTGCTGTGTTTGTGAAACAGA
GAAAGGGGACCCCCGAGGACCCCAGACAGGGCCTTAGGACTCTCATATCTTCTTGTCTTCTCCATCTGGTGGCTCTTGCTCTCTGGTTTT

>8785_8785_2_B9D1-ALDH16A1_B9D1_chr17_19263633_ENST00000268841_ALDH16A1_chr19_49961743_ENST00000293350_length(amino acids)=816AA_BP=44
MATASPSVFLLMVNGQVESAQFPEYDDLYCKYCFVYGQDWAPTAAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQA
EDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPM
GVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQPGIRKVAFCGAPEEGR
ALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARG
AAACDLVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLG
QALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAP
PYGLFVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQGAE
LKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEV
CQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAEGAGPELGLRVARTKAL

--------------------------------------------------------------
>8785_8785_3_B9D1-ALDH16A1_B9D1_chr17_19263633_ENST00000395615_ALDH16A1_chr19_49961743_ENST00000293350_length(transcript)=3039nt_BP=139nt
ACCTGCCATGGCGACCGCGAGTCCTAGCGTCTTTCTACTCATGGTCAACGGGCAGGTGGAGAGCGCCCAGTTTCCAGAGTATGATGACCT
CTACTGCAAGTACTGCTTTGTGTACGGCCAGGACTGGGCCCCCACAGCGGCCTGGCTGGACACCCAGGACCGGTGCTTGGGCCACTATGT
GAATGGGAAGTGGTTAAAGCCTGAACACAGAAATTCAGTGCCTTGCCAGGATCCCATCACAGGAGAGAACTTGGCCAGTTGCCTGCAGGC
ACAGGCCGAGGATGTGGCTGCAGCCGTGGAGGCAGCCAGGATGGCATTTAAGGGCTGGAGTGCGCACCCCGGCGTCGTCCGGGCCCAGCA
CCTGACCAGGCTGGCCGAGGTGATCCAGAAGCACCAGCGGCTGCTGTGGACCCTGGAATCCCTGGTGACTGGGCGGGCTGTTCGAGAGGT
TCGAGACGGGGACGTCCAGCTGGCCCAGCAGCTGCTCCACTACCATGCAATCCAGGCATCCACCCAGGAGGAGGCACTGGCAGGCTGGGA
GCCCATGGGAGTAATTGGCCTCATCCTGCCACCCACATTCTCCTTCCTTGAGATGATGTGGAGGATTTGCCCTGCCCTGGCTGTGGGCTG
CACCGTGGTGGCCCTCGTGCCCCCGGCCTCCCCGGCGCCCCTCCTCCTGGCCCAGCTGGCGGGGGAGCTGGGCCCCTTCCCGGGAATCCT
GAATGTCCTCAGTGGCCCTGCGTCCCTGGTGCCCATCCTGGCCTCCCAGCCTGGAATCCGGAAGGTGGCCTTCTGCGGAGCCCCGGAGGA
AGGGCGTGCCCTTCGACGGAGCCTGGCGGGAGAGTGTGCGGAGCTGGGCCTGGCGCTGGGGACGGAGTCGCTGCTGCTGCTGACGGACAC
GGCGGACGTAGACTCGGCCGTGGAGGGTGTCGTGGACGCCGCCTGGTCCGACCGCGGCCCGGGTGGCCTCAGGCTCCTCATCCAGGAGTC
TGTGTGGGATGAAGCCATGAGACGGCTGCAGGAGCGGATGGGGCGGCTTCGGAGTGGCCGAGGGCTGGATGGGGCCGTGGACATGGGGGC
CCGGGGGGCTGCCGCATGTGACCTGGTCCAGCGCTTTGTGCGTGAGGCCCAGAGCCAGGGTGCACAGGTGTTCCAGGCTGGTGATGTGCC
TTCGGAACGCCCATTCTATCCCCCAACCTTGGTCTCCAACCTGCCCCCAGCCTCCCCATGTGCCCAGGTGGAGGTGCCGTGGCCTGTGGT
CGTGGCCTCCCCCTTCCGCACAGCCAAGGAGGCACTGTTGGTGGCCAACGGGACGCCCCGCGGGGGCAGCGCCAGTGTGTGGAGCGAGAG
GCTGGGGCAGGCGCTGGAGCTGGGCTATGGGCTCCAGGTGGGCACTGTCTGGATCAACGCCCACGGCCTCAGAGACCCTTCGGTGCCCAC
AGGCGGCTGCAAGGAGAGTGGGTGTTCCTGGCACGGGGGCCCAGACGGGCTGTATGAGTATCTGCGGCCCTCAGGGACCCCTGCCCGGCT
GTCCTGCCTCTCCAAGAACCTGAACTATGACACCTTTGGCCTCGCTGTTCCCTCAACCCTGCCGGCTGGGCCTGAAATAGGGCCCAGCCC
AGCACCCCCCTATGGGCTCTTCGTTGGGGGCCGTTTCCAGGCTCCTGGGGCCCGAAGCTCCAGGCCCATCCGGGATTCGTCTGGCAACCT
CCATGGCTACGTGGCTGAGGGTGGAGCCAAGGACATCCGAGGTGCTGTGGAGGCCGCTCACCAGGCTTTCCCTGGCTGGGCGGGCCAGTC
CCCAGGAGCCCGGGCAGCCCTGCTGTGGGCCCTGGCGGCTGCACTGGAGCGCCGGAAGTCTACCCTGGCCTCGAGGCTGGAGAGGCAGGG
AGCGGAGCTCAAGGCTGCGGAGGCGGAGGTGGAGCTGAGCGCAAGACGACTTCGGGCGTGGGGGGCCCGGGTGCAGGCCCAAGGCCACAC
CCTGCAGGTAGCCGGGCTGAGAGGCCCTGTGCTGCGCCTGCGGGAGCCGCTGGGTGTGCTGGCTGTGGTGTGTCCGGACGAGTGGCCCCT
GCTTGCCTTCGTGTCCCTGCTGGCTCCCGCCCTGGCCTACGGCAACACTGTGGTCATGGTGCCCAGTGCGGCCTGTCCTCTGCTGGCCCT
GGAGGTCTGCCAGGACATGGCCACCGTGTTCCCAGCAGGCCTGGCCAACGTGGTGACAGGAGACCGGGACCATCTGACCCGCTGCCTGGC
CTTGCACCAAGACGTCCAGGCCATGTGGTATTTCGGATCAGCCCAGGGTTCCCAGTTTGTCGAGTGGGCCTCGGCAGGAAACCTCAAACC
GGTGTGGGCGAGCAGGGGCTGCCCGCGGGCCTGGGACCAGGAGGCCGAGGGGGCAGGCCCAGAGCTGGGGCTGCGAGTGGCGCGGACCAA
GGCCCTGTGGCTGCCTATGGGGGACTGATGCCTGAGCGCCACCTACTGCATTTTGGACACCTCACACCAAGGGGAGATGCACCCCACAGA
CACCTGGGACTTTCCCCTTCTGGTTCCTGTGTCTCCCAATAAACTCTCTGACCAACCCTAGCTGTGCTTCTGCGAGAAGAAAGGGTGTAG
CAACTTCTGGCAGATATGAGGCTTTTTTCTTTTTTTTTTTTTTTTTTGAGACAACGTCTGGCTCTGTCACCCAGGCTGGAGCGCAGTGGC
ACAATCTCGGCCCACTGCAGCCTCGACCTCTGGGGCTCAAGGGATCCTCATGCCTCAGCCTCATATGTAGCTGGGGCCACAGACATGCAC
CACCACACCTGGCTCGAGGCCATTTTAGTTCTGAGGTTGAGCAGCTCAGGAGCCGGCTCCAGCACGGTGCTGTGTTTGTGAAACAGAGAA
AGGGGACCCCCGAGGACCCCAGACAGGGCCTTAGGACTCTCATATCTTCTTGTCTTCTCCATCTGGTGGCTCTTGCTCTCTGGTTTTCTC

>8785_8785_3_B9D1-ALDH16A1_B9D1_chr17_19263633_ENST00000395615_ALDH16A1_chr19_49961743_ENST00000293350_length(amino acids)=816AA_BP=44
MATASPSVFLLMVNGQVESAQFPEYDDLYCKYCFVYGQDWAPTAAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQA
EDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPM
GVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQPGIRKVAFCGAPEEGR
ALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARG
AAACDLVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLG
QALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAP
PYGLFVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQGAE
LKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEV
CQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAEGAGPELGLRVARTKAL

--------------------------------------------------------------
>8785_8785_4_B9D1-ALDH16A1_B9D1_chr17_19263633_ENST00000395616_ALDH16A1_chr19_49961743_ENST00000293350_length(transcript)=3196nt_BP=296nt
CTGCGCCTGCGCATGCCACACGCGCACTCGCGTGGCCTTCGCGAAGGTGTCGCTGCCAAGAAACGTGTCCTGCGCGCTACGCCGTCTGTT
TCTAGGGCAACGCCGGCGTCTCTTAGCAACCGCGCGCGGCCTAGGTGGGTCCCCCCGGCACCCCCAGACCTGCCATGGCGACCGCGAGTC
CTAGCGTCTTTCTACTCATGGTCAACGGGCAGGTGGAGAGCGCCCAGTTTCCAGAGTATGATGACCTCTACTGCAAGTACTGCTTTGTGT
ACGGCCAGGACTGGGCCCCCACAGCGGCCTGGCTGGACACCCAGGACCGGTGCTTGGGCCACTATGTGAATGGGAAGTGGTTAAAGCCTG
AACACAGAAATTCAGTGCCTTGCCAGGATCCCATCACAGGAGAGAACTTGGCCAGTTGCCTGCAGGCACAGGCCGAGGATGTGGCTGCAG
CCGTGGAGGCAGCCAGGATGGCATTTAAGGGCTGGAGTGCGCACCCCGGCGTCGTCCGGGCCCAGCACCTGACCAGGCTGGCCGAGGTGA
TCCAGAAGCACCAGCGGCTGCTGTGGACCCTGGAATCCCTGGTGACTGGGCGGGCTGTTCGAGAGGTTCGAGACGGGGACGTCCAGCTGG
CCCAGCAGCTGCTCCACTACCATGCAATCCAGGCATCCACCCAGGAGGAGGCACTGGCAGGCTGGGAGCCCATGGGAGTAATTGGCCTCA
TCCTGCCACCCACATTCTCCTTCCTTGAGATGATGTGGAGGATTTGCCCTGCCCTGGCTGTGGGCTGCACCGTGGTGGCCCTCGTGCCCC
CGGCCTCCCCGGCGCCCCTCCTCCTGGCCCAGCTGGCGGGGGAGCTGGGCCCCTTCCCGGGAATCCTGAATGTCCTCAGTGGCCCTGCGT
CCCTGGTGCCCATCCTGGCCTCCCAGCCTGGAATCCGGAAGGTGGCCTTCTGCGGAGCCCCGGAGGAAGGGCGTGCCCTTCGACGGAGCC
TGGCGGGAGAGTGTGCGGAGCTGGGCCTGGCGCTGGGGACGGAGTCGCTGCTGCTGCTGACGGACACGGCGGACGTAGACTCGGCCGTGG
AGGGTGTCGTGGACGCCGCCTGGTCCGACCGCGGCCCGGGTGGCCTCAGGCTCCTCATCCAGGAGTCTGTGTGGGATGAAGCCATGAGAC
GGCTGCAGGAGCGGATGGGGCGGCTTCGGAGTGGCCGAGGGCTGGATGGGGCCGTGGACATGGGGGCCCGGGGGGCTGCCGCATGTGACC
TGGTCCAGCGCTTTGTGCGTGAGGCCCAGAGCCAGGGTGCACAGGTGTTCCAGGCTGGTGATGTGCCTTCGGAACGCCCATTCTATCCCC
CAACCTTGGTCTCCAACCTGCCCCCAGCCTCCCCATGTGCCCAGGTGGAGGTGCCGTGGCCTGTGGTCGTGGCCTCCCCCTTCCGCACAG
CCAAGGAGGCACTGTTGGTGGCCAACGGGACGCCCCGCGGGGGCAGCGCCAGTGTGTGGAGCGAGAGGCTGGGGCAGGCGCTGGAGCTGG
GCTATGGGCTCCAGGTGGGCACTGTCTGGATCAACGCCCACGGCCTCAGAGACCCTTCGGTGCCCACAGGCGGCTGCAAGGAGAGTGGGT
GTTCCTGGCACGGGGGCCCAGACGGGCTGTATGAGTATCTGCGGCCCTCAGGGACCCCTGCCCGGCTGTCCTGCCTCTCCAAGAACCTGA
ACTATGACACCTTTGGCCTCGCTGTTCCCTCAACCCTGCCGGCTGGGCCTGAAATAGGGCCCAGCCCAGCACCCCCCTATGGGCTCTTCG
TTGGGGGCCGTTTCCAGGCTCCTGGGGCCCGAAGCTCCAGGCCCATCCGGGATTCGTCTGGCAACCTCCATGGCTACGTGGCTGAGGGTG
GAGCCAAGGACATCCGAGGTGCTGTGGAGGCCGCTCACCAGGCTTTCCCTGGCTGGGCGGGCCAGTCCCCAGGAGCCCGGGCAGCCCTGC
TGTGGGCCCTGGCGGCTGCACTGGAGCGCCGGAAGTCTACCCTGGCCTCGAGGCTGGAGAGGCAGGGAGCGGAGCTCAAGGCTGCGGAGG
CGGAGGTGGAGCTGAGCGCAAGACGACTTCGGGCGTGGGGGGCCCGGGTGCAGGCCCAAGGCCACACCCTGCAGGTAGCCGGGCTGAGAG
GCCCTGTGCTGCGCCTGCGGGAGCCGCTGGGTGTGCTGGCTGTGGTGTGTCCGGACGAGTGGCCCCTGCTTGCCTTCGTGTCCCTGCTGG
CTCCCGCCCTGGCCTACGGCAACACTGTGGTCATGGTGCCCAGTGCGGCCTGTCCTCTGCTGGCCCTGGAGGTCTGCCAGGACATGGCCA
CCGTGTTCCCAGCAGGCCTGGCCAACGTGGTGACAGGAGACCGGGACCATCTGACCCGCTGCCTGGCCTTGCACCAAGACGTCCAGGCCA
TGTGGTATTTCGGATCAGCCCAGGGTTCCCAGTTTGTCGAGTGGGCCTCGGCAGGAAACCTCAAACCGGTGTGGGCGAGCAGGGGCTGCC
CGCGGGCCTGGGACCAGGAGGCCGAGGGGGCAGGCCCAGAGCTGGGGCTGCGAGTGGCGCGGACCAAGGCCCTGTGGCTGCCTATGGGGG
ACTGATGCCTGAGCGCCACCTACTGCATTTTGGACACCTCACACCAAGGGGAGATGCACCCCACAGACACCTGGGACTTTCCCCTTCTGG
TTCCTGTGTCTCCCAATAAACTCTCTGACCAACCCTAGCTGTGCTTCTGCGAGAAGAAAGGGTGTAGCAACTTCTGGCAGATATGAGGCT
TTTTTCTTTTTTTTTTTTTTTTTTGAGACAACGTCTGGCTCTGTCACCCAGGCTGGAGCGCAGTGGCACAATCTCGGCCCACTGCAGCCT
CGACCTCTGGGGCTCAAGGGATCCTCATGCCTCAGCCTCATATGTAGCTGGGGCCACAGACATGCACCACCACACCTGGCTCGAGGCCAT
TTTAGTTCTGAGGTTGAGCAGCTCAGGAGCCGGCTCCAGCACGGTGCTGTGTTTGTGAAACAGAGAAAGGGGACCCCCGAGGACCCCAGA
CAGGGCCTTAGGACTCTCATATCTTCTTGTCTTCTCCATCTGGTGGCTCTTGCTCTCTGGTTTTCTCTACCTTTTCATGGCCCCAGAATC

>8785_8785_4_B9D1-ALDH16A1_B9D1_chr17_19263633_ENST00000395616_ALDH16A1_chr19_49961743_ENST00000293350_length(amino acids)=816AA_BP=44
MATASPSVFLLMVNGQVESAQFPEYDDLYCKYCFVYGQDWAPTAAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQA
EDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPM
GVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQPGIRKVAFCGAPEEGR
ALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARG
AAACDLVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLG
QALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAP
PYGLFVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQGAE
LKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEV
CQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAEGAGPELGLRVARTKAL

--------------------------------------------------------------
>8785_8785_5_B9D1-ALDH16A1_B9D1_chr17_19263633_ENST00000461069_ALDH16A1_chr19_49961743_ENST00000293350_length(transcript)=3077nt_BP=177nt
CCGCGCGCGGCCTAGGTGGGTCCCCCCGGCACCCCCAGACCTGCCATGGCGACCGCGAGTCCTAGCGTCTTTCTACTCATGGTCAACGGG
CAGGTGGAGAGCGCCCAGTTTCCAGAGTATGATGACCTCTACTGCAAGTACTGCTTTGTGTACGGCCAGGACTGGGCCCCCACAGCGGCC
TGGCTGGACACCCAGGACCGGTGCTTGGGCCACTATGTGAATGGGAAGTGGTTAAAGCCTGAACACAGAAATTCAGTGCCTTGCCAGGAT
CCCATCACAGGAGAGAACTTGGCCAGTTGCCTGCAGGCACAGGCCGAGGATGTGGCTGCAGCCGTGGAGGCAGCCAGGATGGCATTTAAG
GGCTGGAGTGCGCACCCCGGCGTCGTCCGGGCCCAGCACCTGACCAGGCTGGCCGAGGTGATCCAGAAGCACCAGCGGCTGCTGTGGACC
CTGGAATCCCTGGTGACTGGGCGGGCTGTTCGAGAGGTTCGAGACGGGGACGTCCAGCTGGCCCAGCAGCTGCTCCACTACCATGCAATC
CAGGCATCCACCCAGGAGGAGGCACTGGCAGGCTGGGAGCCCATGGGAGTAATTGGCCTCATCCTGCCACCCACATTCTCCTTCCTTGAG
ATGATGTGGAGGATTTGCCCTGCCCTGGCTGTGGGCTGCACCGTGGTGGCCCTCGTGCCCCCGGCCTCCCCGGCGCCCCTCCTCCTGGCC
CAGCTGGCGGGGGAGCTGGGCCCCTTCCCGGGAATCCTGAATGTCCTCAGTGGCCCTGCGTCCCTGGTGCCCATCCTGGCCTCCCAGCCT
GGAATCCGGAAGGTGGCCTTCTGCGGAGCCCCGGAGGAAGGGCGTGCCCTTCGACGGAGCCTGGCGGGAGAGTGTGCGGAGCTGGGCCTG
GCGCTGGGGACGGAGTCGCTGCTGCTGCTGACGGACACGGCGGACGTAGACTCGGCCGTGGAGGGTGTCGTGGACGCCGCCTGGTCCGAC
CGCGGCCCGGGTGGCCTCAGGCTCCTCATCCAGGAGTCTGTGTGGGATGAAGCCATGAGACGGCTGCAGGAGCGGATGGGGCGGCTTCGG
AGTGGCCGAGGGCTGGATGGGGCCGTGGACATGGGGGCCCGGGGGGCTGCCGCATGTGACCTGGTCCAGCGCTTTGTGCGTGAGGCCCAG
AGCCAGGGTGCACAGGTGTTCCAGGCTGGTGATGTGCCTTCGGAACGCCCATTCTATCCCCCAACCTTGGTCTCCAACCTGCCCCCAGCC
TCCCCATGTGCCCAGGTGGAGGTGCCGTGGCCTGTGGTCGTGGCCTCCCCCTTCCGCACAGCCAAGGAGGCACTGTTGGTGGCCAACGGG
ACGCCCCGCGGGGGCAGCGCCAGTGTGTGGAGCGAGAGGCTGGGGCAGGCGCTGGAGCTGGGCTATGGGCTCCAGGTGGGCACTGTCTGG
ATCAACGCCCACGGCCTCAGAGACCCTTCGGTGCCCACAGGCGGCTGCAAGGAGAGTGGGTGTTCCTGGCACGGGGGCCCAGACGGGCTG
TATGAGTATCTGCGGCCCTCAGGGACCCCTGCCCGGCTGTCCTGCCTCTCCAAGAACCTGAACTATGACACCTTTGGCCTCGCTGTTCCC
TCAACCCTGCCGGCTGGGCCTGAAATAGGGCCCAGCCCAGCACCCCCCTATGGGCTCTTCGTTGGGGGCCGTTTCCAGGCTCCTGGGGCC
CGAAGCTCCAGGCCCATCCGGGATTCGTCTGGCAACCTCCATGGCTACGTGGCTGAGGGTGGAGCCAAGGACATCCGAGGTGCTGTGGAG
GCCGCTCACCAGGCTTTCCCTGGCTGGGCGGGCCAGTCCCCAGGAGCCCGGGCAGCCCTGCTGTGGGCCCTGGCGGCTGCACTGGAGCGC
CGGAAGTCTACCCTGGCCTCGAGGCTGGAGAGGCAGGGAGCGGAGCTCAAGGCTGCGGAGGCGGAGGTGGAGCTGAGCGCAAGACGACTT
CGGGCGTGGGGGGCCCGGGTGCAGGCCCAAGGCCACACCCTGCAGGTAGCCGGGCTGAGAGGCCCTGTGCTGCGCCTGCGGGAGCCGCTG
GGTGTGCTGGCTGTGGTGTGTCCGGACGAGTGGCCCCTGCTTGCCTTCGTGTCCCTGCTGGCTCCCGCCCTGGCCTACGGCAACACTGTG
GTCATGGTGCCCAGTGCGGCCTGTCCTCTGCTGGCCCTGGAGGTCTGCCAGGACATGGCCACCGTGTTCCCAGCAGGCCTGGCCAACGTG
GTGACAGGAGACCGGGACCATCTGACCCGCTGCCTGGCCTTGCACCAAGACGTCCAGGCCATGTGGTATTTCGGATCAGCCCAGGGTTCC
CAGTTTGTCGAGTGGGCCTCGGCAGGAAACCTCAAACCGGTGTGGGCGAGCAGGGGCTGCCCGCGGGCCTGGGACCAGGAGGCCGAGGGG
GCAGGCCCAGAGCTGGGGCTGCGAGTGGCGCGGACCAAGGCCCTGTGGCTGCCTATGGGGGACTGATGCCTGAGCGCCACCTACTGCATT
TTGGACACCTCACACCAAGGGGAGATGCACCCCACAGACACCTGGGACTTTCCCCTTCTGGTTCCTGTGTCTCCCAATAAACTCTCTGAC
CAACCCTAGCTGTGCTTCTGCGAGAAGAAAGGGTGTAGCAACTTCTGGCAGATATGAGGCTTTTTTCTTTTTTTTTTTTTTTTTTGAGAC
AACGTCTGGCTCTGTCACCCAGGCTGGAGCGCAGTGGCACAATCTCGGCCCACTGCAGCCTCGACCTCTGGGGCTCAAGGGATCCTCATG
CCTCAGCCTCATATGTAGCTGGGGCCACAGACATGCACCACCACACCTGGCTCGAGGCCATTTTAGTTCTGAGGTTGAGCAGCTCAGGAG
CCGGCTCCAGCACGGTGCTGTGTTTGTGAAACAGAGAAAGGGGACCCCCGAGGACCCCAGACAGGGCCTTAGGACTCTCATATCTTCTTG
TCTTCTCCATCTGGTGGCTCTTGCTCTCTGGTTTTCTCTACCTTTTCATGGCCCCAGAATCCATATGCAGTAAAGGAACTCTCTGGAATA

>8785_8785_5_B9D1-ALDH16A1_B9D1_chr17_19263633_ENST00000461069_ALDH16A1_chr19_49961743_ENST00000293350_length(amino acids)=816AA_BP=44
MATASPSVFLLMVNGQVESAQFPEYDDLYCKYCFVYGQDWAPTAAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQA
EDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPM
GVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQPGIRKVAFCGAPEEGR
ALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARG
AAACDLVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLG
QALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAP
PYGLFVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQGAE
LKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEV
CQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAEGAGPELGLRVARTKAL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for B9D1-ALDH16A1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for B9D1-ALDH16A1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for B9D1-ALDH16A1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	B9D1	C3280155	MECKEL SYNDROME, TYPE 9	3	GENOMICS_ENGLAND
Hgene	B9D1	C3714506	Meckel syndrome type 1	3	GENOMICS_ENGLAND
Hgene	B9D1	C4277690	Ciliopathies	3	GENOMICS_ENGLAND
Hgene	B9D1	C4310706	JOUBERT SYNDROME 27	3	GENOMICS_ENGLAND;UNIPROT
Hgene	B9D1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	B9D1	C0152427	Polydactyly	1	GENOMICS_ENGLAND
Hgene	B9D1	C0238198	Gastrointestinal Stromal Tumors	1	CTD_human
Hgene	B9D1	C0265215	Meckel-Gruber syndrome	1	ORPHANET
Hgene	B9D1	C0431399	Familial aplasia of the vermis	1	ORPHANET
Hgene	B9D1	C3179349	Gastrointestinal Stromal Sarcoma	1	CTD_human
Hgene	B9D1	C4551568	Joubert syndrome 1	1	ORPHANET
Tgene		C0018099	Gout	1	CTD_human
Tgene		C0268117	Gout, HPRT-Related	1	CTD_human
Tgene		C0740394	Hyperuricemia	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:B9D1-ALDH16A1 (FusionGDB2 ID:HG27077TG126133)

Fusion Gene Summary for B9D1-ALDH16A1

Fusion Gene ORF analysis for B9D1-ALDH16A1

Fusion Genomic Features for B9D1-ALDH16A1

Fusion Protein Features for B9D1-ALDH16A1

Fusion Gene Sequence for B9D1-ALDH16A1

Fusion Gene PPI Analysis for B9D1-ALDH16A1

Related Drugs for B9D1-ALDH16A1

Related Diseases for B9D1-ALDH16A1

Fusion Gene Studies
in Kim Lab