Fusion gene information | Fusion gene name: BRPF3-N4BP2L2 |
Fusion gene ID: hg27154tg10443 | | Hgene | Tgene | Gene symbol | BRPF3 | N4BP2L2 | Gene ID | 27154 | 10443 | Gene name | bromodomain and PHD finger containing 3 | NEDD4 binding protein 2 like 2 |
Synonyms | - | 92M18.3|CG005|CG016|PFAAP5 |
Cytomap | ('BRPF3')('N4BP2L2') 6p21.31 | 13q13.1 |
Type of gene | protein-coding | protein-coding |
Description | bromodomain and PHD finger-containing protein 3 | NEDD4-binding protein 2-like 2phosphonoformate immuno-associated protein 5protein from BRCA2 region |
Modification date | 20200327 | 20200320 |
UniProtAcc | . | . |
Ensembl transtripts involved in fusion gene | ENST00000339717, ENST00000357641, ENST00000443324, ENST00000534400, ENST00000534694, ENST00000543502,
| |
Fusion gene scores | * DoF score | 6 X 5 X 6=180 | 24 X 15 X 7=2520 |
# samples | 6 | 27 |
** MAII score | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(27/2520*10)=-3.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 |
Context | PubMed: BRPF3 [Title/Abstract] AND N4BP2L2 [Title/Abstract] AND fusion [Title/Abstract] |
Most frequent breakpoint | BRPF3(36168351)-N4BP2L2(33054769), # samples:1
|
Anticipated loss of major functional domain due to fusion event. | BRPF3-N4BP2L2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. BRPF3-N4BP2L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. BRPF3-N4BP2L2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
|
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |