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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARFIP1-FBXW7 (FusionGDB2 ID:HG27236TG55294)

Fusion Gene Summary for ARFIP1-FBXW7

check button Fusion gene summary
Fusion gene informationFusion gene name: ARFIP1-FBXW7
Fusion gene ID: hg27236tg55294
HgeneTgene
Gene symbol

ARFIP1

FBXW7

Gene ID

27236

55294

Gene nameADP ribosylation factor interacting protein 1F-box and WD repeat domain containing 7
SynonymsHSU52521AGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10|hAgo|hCdc4
Cytomap('ARFIP1')('FBXW7')

4q31.3

4q31.3

Type of geneprotein-codingprotein-coding
Descriptionarfaptin-1F-box/WD repeat-containing protein 7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligaseF-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)F-box protein FBW7F-box protein FBX30F-box protein SEL-10archipelagohomolog of
Modification date2020031320200327
UniProtAcc

P53367

.
Ensembl transtripts involved in fusion geneENST00000353617, ENST00000356064, 
ENST00000405727, ENST00000429148, 
ENST00000451320, ENST00000511289, 
ENST00000511289, ENST00000353617, 
ENST00000356064, ENST00000405727, 
ENST00000451320, ENST00000429148, 
Fusion gene scores* DoF score11 X 7 X 7=5396 X 6 X 4=144
# samples 117
** MAII scorelog2(11/539*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARFIP1 [Title/Abstract] AND FBXW7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARFIP1(153701378)-FBXW7(153271276), # samples:1
Anticipated loss of major functional domain due to fusion event.FBXW7-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXW7-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXW7-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
FBXW7-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FBXW7-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARFIP1

GO:0006886

intracellular protein transport

12606037

HgeneARFIP1

GO:0050708

regulation of protein secretion

12606037

TgeneFBXW7

GO:0016567

protein ubiquitination

12354302|15103331

TgeneFBXW7

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

15103331|17434132

TgeneFBXW7

GO:0031398

positive regulation of protein ubiquitination

12628165

TgeneFBXW7

GO:0045741

positive regulation of epidermal growth factor-activated receptor activity

20208556

TgeneFBXW7

GO:0050821

protein stabilization

20208556

TgeneFBXW7

GO:0051443

positive regulation of ubiquitin-protein transferase activity

12628165

TgeneFBXW7

GO:1901800

positive regulation of proteasomal protein catabolic process

23858059

TgeneFBXW7

GO:1903378

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

23858059

TgeneFBXW7

GO:2000060

positive regulation of ubiquitin-dependent protein catabolic process

20208556



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8527-01AARFIP1chr4

153701378

+FBXW7chr4

153271276

-


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Fusion Gene ORF analysis for ARFIP1-FBXW7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000353617ENST00000281708ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-3CDSENST00000353617ENST00000603548ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-3CDSENST00000356064ENST00000281708ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-3CDSENST00000356064ENST00000603548ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-intronENST00000353617ENST00000263981ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-intronENST00000353617ENST00000296555ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-intronENST00000353617ENST00000393956ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-intronENST00000353617ENST00000603841ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-intronENST00000353617ENST00000604095ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-intronENST00000353617ENST00000604872ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-intronENST00000356064ENST00000263981ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-intronENST00000356064ENST00000296555ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-intronENST00000356064ENST00000393956ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-intronENST00000356064ENST00000603841ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-intronENST00000356064ENST00000604095ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
5UTR-intronENST00000356064ENST00000604872ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-3CDSENST00000405727ENST00000281708ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-3CDSENST00000405727ENST00000603548ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-3CDSENST00000429148ENST00000281708ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-3CDSENST00000429148ENST00000603548ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-3CDSENST00000451320ENST00000281708ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-3CDSENST00000451320ENST00000603548ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-3CDSENST00000511289ENST00000281708ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-3CDSENST00000511289ENST00000603548ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000405727ENST00000263981ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000405727ENST00000296555ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000405727ENST00000393956ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000405727ENST00000603841ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000405727ENST00000604095ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000405727ENST00000604872ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000429148ENST00000263981ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000429148ENST00000296555ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000429148ENST00000393956ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000429148ENST00000603841ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000429148ENST00000604095ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000429148ENST00000604872ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000451320ENST00000263981ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000451320ENST00000296555ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000451320ENST00000393956ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000451320ENST00000603841ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000451320ENST00000604095ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000451320ENST00000604872ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000511289ENST00000263981ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000511289ENST00000296555ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000511289ENST00000393956ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000511289ENST00000603841ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000511289ENST00000604095ARFIP1chr4

153701378

+FBXW7chr4

153271276

-
intron-intronENST00000511289ENST00000604872ARFIP1chr4

153701378

+FBXW7chr4

153271276

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARFIP1-FBXW7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ARFIP1-FBXW7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:153701378/:153271276)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARFIP1

P53367

.
FUNCTION: Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:9038142, PubMed:22981988). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARFIP1-FBXW7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARFIP1-FBXW7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARFIP1-FBXW7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARFIP1-FBXW7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma2CGI;CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human;UNIPROT
TgeneC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneC0014170Endometrial Neoplasms1CTD_human
TgeneC0017638Glioma1CTD_human
TgeneC0259783mixed gliomas1CTD_human
TgeneC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneC0476089Endometrial Carcinoma1CGI;CTD_human
TgeneC0555198Malignant Glioma1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0919532Genomic Instability1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1368275Pigmented Basal Cell Carcinoma1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human
TgeneC4721806Carcinoma, Basal Cell1CTD_human