Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:AHDC1-MORN1 (FusionGDB2 ID:HG27245TG79906)

Fusion Gene Summary for AHDC1-MORN1

check button Fusion gene summary
Fusion gene informationFusion gene name: AHDC1-MORN1
Fusion gene ID: hg27245tg79906
HgeneTgene
Gene symbol

AHDC1

MORN1

Gene ID

27245

79906

Gene nameAT-hook DNA binding motif containing 1MORN repeat containing 1
SynonymsMRD25-
Cytomap('AHDC1')('MORN1')

1p36.11-p35.3

1p36.32

Type of geneprotein-codingprotein-coding
DescriptionAT-hook DNA-binding motif-containing protein 1MORN repeat-containing protein 1
Modification date2020031320200313
UniProtAcc

Q5TGY3

Q5T089

Ensembl transtripts involved in fusion geneENST00000247087, ENST00000374011, 
ENST00000480033, 
Fusion gene scores* DoF score15 X 11 X 10=16505 X 5 X 3=75
# samples 185
** MAII scorelog2(18/1650*10)=-3.1963972128035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AHDC1 [Title/Abstract] AND MORN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAHDC1(27873772)-MORN1(2268289), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-B0-4690-01AAHDC1chr1

27873772

-MORN1chr1

2268289

-
ChimerDB4KIRCTCGA-B0-4690-01AAHDC1chr1

27879403

-MORN1chr1

2268289

-


Top

Fusion Gene ORF analysis for AHDC1-MORN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000247087ENST00000378531AHDC1chr1

27873772

-MORN1chr1

2268289

-
3UTR-3CDSENST00000374011ENST00000378531AHDC1chr1

27873772

-MORN1chr1

2268289

-
3UTR-5UTRENST00000247087ENST00000606372AHDC1chr1

27873772

-MORN1chr1

2268289

-
3UTR-5UTRENST00000374011ENST00000606372AHDC1chr1

27873772

-MORN1chr1

2268289

-
3UTR-intronENST00000247087ENST00000378529AHDC1chr1

27873772

-MORN1chr1

2268289

-
3UTR-intronENST00000374011ENST00000378529AHDC1chr1

27873772

-MORN1chr1

2268289

-
5UTR-3CDSENST00000247087ENST00000378531AHDC1chr1

27879403

-MORN1chr1

2268289

-
5UTR-3CDSENST00000374011ENST00000378531AHDC1chr1

27879403

-MORN1chr1

2268289

-
5UTR-5UTRENST00000247087ENST00000606372AHDC1chr1

27879403

-MORN1chr1

2268289

-
5UTR-5UTRENST00000374011ENST00000606372AHDC1chr1

27879403

-MORN1chr1

2268289

-
5UTR-intronENST00000247087ENST00000378529AHDC1chr1

27879403

-MORN1chr1

2268289

-
5UTR-intronENST00000374011ENST00000378529AHDC1chr1

27879403

-MORN1chr1

2268289

-
intron-3CDSENST00000480033ENST00000378531AHDC1chr1

27873772

-MORN1chr1

2268289

-
intron-3CDSENST00000480033ENST00000378531AHDC1chr1

27879403

-MORN1chr1

2268289

-
intron-5UTRENST00000480033ENST00000606372AHDC1chr1

27873772

-MORN1chr1

2268289

-
intron-5UTRENST00000480033ENST00000606372AHDC1chr1

27879403

-MORN1chr1

2268289

-
intron-intronENST00000480033ENST00000378529AHDC1chr1

27873772

-MORN1chr1

2268289

-
intron-intronENST00000480033ENST00000378529AHDC1chr1

27879403

-MORN1chr1

2268289

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for AHDC1-MORN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


Top

Fusion Protein Features for AHDC1-MORN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:27873772/:2268289)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AHDC1

Q5TGY3

MORN1

Q5T089


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for AHDC1-MORN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for AHDC1-MORN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for AHDC1-MORN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for AHDC1-MORN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAHDC1C4014419AHDC1-related intellectual disability, obstructive sleep apnea, mild dysmorphism syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0032460Polycystic Ovary Syndrome1CTD_human
TgeneC1136382Sclerocystic Ovaries1CTD_human