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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GNAL-CSNK1E (FusionGDB2 ID:HG2774TG1454)

Fusion Gene Summary for GNAL-CSNK1E

check button Fusion gene summary
Fusion gene informationFusion gene name: GNAL-CSNK1E
Fusion gene ID: hg2774tg1454
HgeneTgene
Gene symbol

GNAL

CSNK1E

Gene ID

2774

1454

Gene nameG protein subunit alpha Lcasein kinase 1 epsilon
SynonymsDYT25CKIe|CKIepsilon|HCKIE
Cytomap('GNAL')('CSNK1E')

18p11.21

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein G(olf) subunit alphaadenylate cyclase-stimulating G alpha protein, olfactory typeguanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory typeguanine nucleotide binding protein casein kinase I isoform epsilon
Modification date2020031320200329
UniProtAcc

P38405

P49674

Ensembl transtripts involved in fusion geneENST00000590972, ENST00000269162, 
ENST00000334049, ENST00000423027, 
ENST00000535121, ENST00000602628, 
Fusion gene scores* DoF score9 X 9 X 3=24310 X 5 X 6=300
# samples 911
** MAII scorelog2(9/243*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/300*10)=-1.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNAL [Title/Abstract] AND CSNK1E [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGNAL(11753944)-CSNK1E(38699253), # samples:2
Anticipated loss of major functional domain due to fusion event.GNAL-CSNK1E seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
GNAL-CSNK1E seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
GNAL-CSNK1E seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCSNK1E

GO:0006468

protein phosphorylation

15917222|17244647

TgeneCSNK1E

GO:0018105

peptidyl-serine phosphorylation

25500533

TgeneCSNK1E

GO:0032091

negative regulation of protein binding

23109420

TgeneCSNK1E

GO:0060070

canonical Wnt signaling pathway

14722104

TgeneCSNK1E

GO:1903827

regulation of cellular protein localization

17244647



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A03V-01AGNALchr18

11753944

-CSNK1Echr22

38699253

-
ChimerDB4BRCATCGA-AO-A03V-01AGNALchr18

11753944

+CSNK1Echr22

38699253

-


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Fusion Gene ORF analysis for GNAL-CSNK1E

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000590972ENST00000359867GNALchr18

11753944

+CSNK1Echr22

38699253

-
3UTR-3CDSENST00000590972ENST00000396832GNALchr18

11753944

+CSNK1Echr22

38699253

-
3UTR-3CDSENST00000590972ENST00000400206GNALchr18

11753944

+CSNK1Echr22

38699253

-
3UTR-3CDSENST00000590972ENST00000403904GNALchr18

11753944

+CSNK1Echr22

38699253

-
3UTR-3CDSENST00000590972ENST00000405675GNALchr18

11753944

+CSNK1Echr22

38699253

-
3UTR-3CDSENST00000590972ENST00000413574GNALchr18

11753944

+CSNK1Echr22

38699253

-
3UTR-intronENST00000590972ENST00000498529GNALchr18

11753944

+CSNK1Echr22

38699253

-
5CDS-intronENST00000269162ENST00000498529GNALchr18

11753944

+CSNK1Echr22

38699253

-
5CDS-intronENST00000334049ENST00000498529GNALchr18

11753944

+CSNK1Echr22

38699253

-
5CDS-intronENST00000423027ENST00000498529GNALchr18

11753944

+CSNK1Echr22

38699253

-
5CDS-intronENST00000535121ENST00000498529GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000269162ENST00000359867GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000269162ENST00000396832GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000269162ENST00000400206GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000269162ENST00000403904GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000269162ENST00000405675GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000269162ENST00000413574GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000334049ENST00000359867GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000334049ENST00000396832GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000334049ENST00000400206GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000334049ENST00000403904GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000334049ENST00000405675GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000334049ENST00000413574GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000423027ENST00000359867GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000423027ENST00000396832GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000423027ENST00000400206GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000423027ENST00000403904GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000423027ENST00000405675GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000423027ENST00000413574GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000535121ENST00000359867GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000535121ENST00000396832GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000535121ENST00000400206GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000535121ENST00000403904GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000535121ENST00000405675GNALchr18

11753944

+CSNK1Echr22

38699253

-
Frame-shiftENST00000535121ENST00000413574GNALchr18

11753944

+CSNK1Echr22

38699253

-
intron-3CDSENST00000602628ENST00000359867GNALchr18

11753944

+CSNK1Echr22

38699253

-
intron-3CDSENST00000602628ENST00000396832GNALchr18

11753944

+CSNK1Echr22

38699253

-
intron-3CDSENST00000602628ENST00000400206GNALchr18

11753944

+CSNK1Echr22

38699253

-
intron-3CDSENST00000602628ENST00000403904GNALchr18

11753944

+CSNK1Echr22

38699253

-
intron-3CDSENST00000602628ENST00000405675GNALchr18

11753944

+CSNK1Echr22

38699253

-
intron-3CDSENST00000602628ENST00000413574GNALchr18

11753944

+CSNK1Echr22

38699253

-
intron-intronENST00000602628ENST00000498529GNALchr18

11753944

+CSNK1Echr22

38699253

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GNAL-CSNK1E


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for GNAL-CSNK1E


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:11753944/:38699253)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNAL

P38405

CSNK1E

P49674

FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. {ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GNAL-CSNK1E


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GNAL-CSNK1E


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GNAL-CSNK1E


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GNAL-CSNK1E


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGNALC3554447DYSTONIA 255GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNALC0005586Bipolar Disorder1PSYGENET
HgeneGNALC0013421Dystonia1CTD_human
HgeneGNALC0036341Schizophrenia1PSYGENET
HgeneGNALC0393588Dystonia, Paroxysmal1CTD_human
HgeneGNALC0393593Dystonia Disorders1CTD_human
HgeneGNALC0393598Idiopathic familial dystonia1CTD_human
HgeneGNALC0393610Dystonia, Diurnal1CTD_human
HgeneGNALC0743332Focal Dystonia1CTD_human
HgeneGNALC0751093Dystonia, Limb1CTD_human
HgeneGNALC0752197Adult-Onset Dystonias1CTD_human
HgeneGNALC0752198Adult-Onset Idiopathic Focal Dystonias1CTD_human
HgeneGNALC0752199Adult-Onset Idiopathic Torsion Dystonias1CTD_human
HgeneGNALC0752200Autosomal Dominant Familial Dystonia1CTD_human
HgeneGNALC0752201Autosomal Recessive Familial Dystonia1CTD_human
HgeneGNALC0752202Childhood Onset Dystonias1CTD_human
HgeneGNALC0752203Dystonia, Primary1CTD_human
HgeneGNALC0752205Dystonia, Secondary1CTD_human
HgeneGNALC0752206Dystonias, Sporadic1CTD_human
HgeneGNALC0752207Familial Dystonia1CTD_human
HgeneGNALC0752208Pseudodystonia1CTD_human
HgeneGNALC4316810Writer's Cramp1CTD_human
TgeneC0005586Bipolar Disorder5PSYGENET
TgeneC0036341Schizophrenia2PSYGENET