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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:GNAO1-FAM81A (FusionGDB2 ID:HG2775TG145773) |
Fusion Gene Summary for GNAO1-FAM81A |
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Fusion gene information | Fusion gene name: GNAO1-FAM81A | Fusion gene ID: hg2775tg145773 | Hgene | Tgene | Gene symbol | GNAO1 | FAM81A | Gene ID | 2775 | 145773 |
Gene name | G protein subunit alpha o1 | family with sequence similarity 81 member A | |
Synonyms | EIEE17|G-ALPHA-o|GNAO|HLA-DQB1|NEDIM | - | |
Cytomap | ('GNAO1')('FAM81A') 16q13 | 15q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | guanine nucleotide-binding protein G(o) subunit alphaGO2-q chimeric G-proteinguanine nucleotide binding protein (G protein), alpha activating activity polypeptide Oguanine nucleotide-binding regulatory protein 2 | protein FAM81A | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P09471 | Q8TBF8 | |
Ensembl transtripts involved in fusion gene | ENST00000262493, ENST00000262494, ENST00000569295, | ||
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 6 X 6 X 3=108 |
# samples | 4 | 6 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GNAO1 [Title/Abstract] AND FAM81A [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | GNAO1(56390777)-FAM81A(59732524), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for GNAO1-FAM81A |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for GNAO1-FAM81A |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for GNAO1-FAM81A |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:56390777/:59732524) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
GNAO1 | FAM81A |
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for GNAO1-FAM81A |
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Fusion Gene PPI Analysis for GNAO1-FAM81A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for GNAO1-FAM81A |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for GNAO1-FAM81A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GNAO1 | C0393706 | Early infantile epileptic encephalopathy with suppression bursts | 13 | CLINGEN;ORPHANET |
Hgene | GNAO1 | C3463992 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1 | 13 | CLINGEN |
Hgene | GNAO1 | C4552072 | X-linked infantile spasms | 13 | CLINGEN |
Hgene | GNAO1 | C0026650 | Movement Disorders | 6 | CLINGEN |
Hgene | GNAO1 | C4479569 | NEURODEVELOPMENTAL DISORDER WITH INVOLUNTARY MOVEMENTS | 6 | GENOMICS_ENGLAND;UNIPROT |
Hgene | GNAO1 | C3809606 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 17 | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | GNAO1 | C0036341 | Schizophrenia | 2 | PSYGENET |
Hgene | GNAO1 | C0014544 | Epilepsy | 1 | CTD_human |
Hgene | GNAO1 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
Hgene | GNAO1 | C0086189 | Drug Withdrawal Symptoms | 1 | CTD_human |
Hgene | GNAO1 | C0086237 | Epilepsy, Cryptogenic | 1 | CTD_human |
Hgene | GNAO1 | C0087169 | Withdrawal Symptoms | 1 | CTD_human |
Hgene | GNAO1 | C0236018 | Aura | 1 | CTD_human |
Hgene | GNAO1 | C0543888 | Epileptic encephalopathy | 1 | GENOMICS_ENGLAND |
Hgene | GNAO1 | C0751111 | Awakening Epilepsy | 1 | CTD_human |
Hgene | GNAO1 | C1535926 | Neurodevelopmental Disorders | 1 | CTD_human |
Hgene | GNAO1 | C2239176 | Liver carcinoma | 1 | CTD_human |