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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:GNAS-SEC63 (FusionGDB2 ID:HG2778TG11231)

Fusion Gene Summary for GNAS-SEC63

Fusion gene summary

Fusion gene information	Fusion gene name: GNAS-SEC63
	Fusion gene ID: hg2778tg11231
		Hgene	Tgene
	Gene symbol	GNAS	SEC63
	Gene ID	2778	11231
	Gene name	GNAS complex locus	SEC63 homolog, protein translocation regulator
	Synonyms	AHO\|C20orf45\|GNAS1\|GPSA\|GSA\|GSP\|NESP\|PITA3\|POH\|SCG6\|SgVI	DNAJC23\|ERdj2\|PCLD2\|PRO2507\|SEC63L
	Cytomap	('GNAS')('SEC63') 20q13.32	6q21
	Type of gene	protein-coding	protein-coding
	Description	protein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha	translocation protein SEC63 homologSEC63 protein translocation regulatorSEC63-like protein
	Modification date	20200329	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000265620, ENST00000306090, ENST00000313949, ENST00000354359, ENST00000371075, ENST00000371085, ENST00000371095, ENST00000371100, ENST00000371102, ENST00000464624, ENST00000306120, ENST00000371081, ENST00000371098, ENST00000371099,
Fusion gene scores	* DoF score	44 X 25 X 16=17600	38 X 14 X 15=7980
	# samples	51	39
	** MAII score	log2(51/17600*10)=-5.10893437155316 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(39/7980*10)=-4.3548427173601 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GNAS [Title/Abstract] AND SEC63 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GNAS(57486241)-SEC63(108214782), # samples:1
Anticipated loss of major functional domain due to fusion event.	GNAS-SEC63 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GNAS-SEC63 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GNAS-SEC63 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GNAS-SEC63 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GNAS-SEC63 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. GNAS-SEC63 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. GNAS-SEC63 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across GNAS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SEC63 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-EM-A3OB-01A	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-

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Fusion Gene ORF analysis for GNAS-SEC63

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000265620	ENST00000460009	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
5CDS-intron	ENST00000306090	ENST00000460009	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
5CDS-intron	ENST00000313949	ENST00000460009	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
5CDS-intron	ENST00000354359	ENST00000460009	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
5CDS-intron	ENST00000371075	ENST00000460009	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
5CDS-intron	ENST00000371085	ENST00000460009	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
5CDS-intron	ENST00000371095	ENST00000460009	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
5CDS-intron	ENST00000371100	ENST00000460009	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
5CDS-intron	ENST00000371102	ENST00000460009	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
5CDS-intron	ENST00000464624	ENST00000460009	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
Frame-shift	ENST00000313949	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
Frame-shift	ENST00000371075	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
Frame-shift	ENST00000464624	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
In-frame	ENST00000265620	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
In-frame	ENST00000306090	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
In-frame	ENST00000354359	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
In-frame	ENST00000371085	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
In-frame	ENST00000371095	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
In-frame	ENST00000371100	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
In-frame	ENST00000371102	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
intron-3CDS	ENST00000306120	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
intron-3CDS	ENST00000371081	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
intron-3CDS	ENST00000371098	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
intron-3CDS	ENST00000371099	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
intron-intron	ENST00000306120	ENST00000460009	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
intron-intron	ENST00000371081	ENST00000460009	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
intron-intron	ENST00000371098	ENST00000460009	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-
intron-intron	ENST00000371099	ENST00000460009	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000371100	GNAS	chr20	57486241	-	ENST00000369002	SEC63	chr6	108214782	-	8683	4029	531	3665	1044
ENST00000371102	GNAS	chr20	57486241	-	ENST00000369002	SEC63	chr6	108214782	-	8092	3438	3	3074	1023
ENST00000371095	GNAS	chr20	57486241	-	ENST00000369002	SEC63	chr6	108214782	-	6585	1931	1582	2	527
ENST00000371085	GNAS	chr20	57486241	-	ENST00000369002	SEC63	chr6	108214782	-	6626	1972	1623	1	541
ENST00000354359	GNAS	chr20	57486241	-	ENST00000369002	SEC63	chr6	108214782	-	6629	1975	1626	1	542
ENST00000265620	GNAS	chr20	57486241	-	ENST00000369002	SEC63	chr6	108214782	-	6520	1866	1517	0	506
ENST00000306090	GNAS	chr20	57486241	-	ENST00000369002	SEC63	chr6	108214782	-	6296	1642	1299	1	433

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000371100	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-	0.000848319	0.9991517
ENST00000371102	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-	0.000364992	0.999635
ENST00000371095	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-	0.000438183	0.99956185
ENST00000371085	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-	0.000435959	0.999564
ENST00000354359	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-	0.000340468	0.99965954
ENST00000265620	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-	0.000259932	0.99974006
ENST00000306090	ENST00000369002	GNAS	chr20	57486241	-	SEC63	chr6	108214782	-	0.000389695	0.99961036

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Fusion Genomic Features for GNAS-SEC63

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for GNAS-SEC63

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:57486241/chr6:108214782)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371100

641_667

1159

1038.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371100

730_756

1159

1038.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371102

641_667

1145

1024.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371102

730_756

1145

1024.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000313949

78_142

729

26.333333333333332

Compositional bias

Glu-rich

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371075

78_142

730

36.333333333333336

Compositional bias

Glu-rich

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371100

358_522

1159

1038.0

Compositional bias

Ala-rich

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371102

358_522

1145

1024.0

Compositional bias

Ala-rich

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000265620

39_394

501

380.0

Domain

G-alpha

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000306090

39_394

500

381.0

Domain

G-alpha

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000354359

39_394

517

396.0

Domain

G-alpha

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371085

39_394

516

395.0

Domain

G-alpha

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371095

39_394

502

381.0

Domain

G-alpha

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371100

682_1037

1159

1038.0

Domain

G-alpha

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371102

682_1037

1145

1024.0

Domain

G-alpha

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000265620

197_204

501

380.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000265620

223_227

501

380.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000265620

292_295

501

380.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000265620

47_55

501

380.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000306090

197_204

500

381.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000306090

223_227

500

381.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000306090

292_295

500

381.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000306090

47_55

500

381.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000354359

197_204

517

396.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000354359

223_227

517

396.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000354359

292_295

517

396.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000354359

47_55

517

396.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371085

197_204

516

395.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371085

223_227

516

395.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371085

292_295

516

395.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371085

47_55

516

395.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371095

197_204

502

381.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371095

223_227

502

381.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371095

292_295

502

381.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371095

47_55

502

381.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371100

690_698

1159

1038.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371100

840_847

1159

1038.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371100

866_870

1159

1038.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371100

935_938

1159

1038.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371102

690_698

1145

1024.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371102

840_847

1145

1024.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371102

866_870

1145

1024.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371102

935_938

1145

1024.0

Nucleotide binding

GTP

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000265620

196_204

501

380.0

Region

G2 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000265620

219_228

501

380.0

Region

G3 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000265620

288_295

501

380.0

Region

G4 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000265620

364_369

501

380.0

Region

G5 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000265620

42_55

501

380.0

Region

G1 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000306090

196_204

500

381.0

Region

G2 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000306090

219_228

500

381.0

Region

G3 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000306090

288_295

500

381.0

Region

G4 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000306090

364_369

500

381.0

Region

G5 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000306090

42_55

500

381.0

Region

G1 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000354359

196_204

517

396.0

Region

G2 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000354359

219_228

517

396.0

Region

G3 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000354359

288_295

517

396.0

Region

G4 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000354359

364_369

517

396.0

Region

G5 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000354359

42_55

517

396.0

Region

G1 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371085

196_204

516

395.0

Region

G2 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371085

219_228

516

395.0

Region

G3 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371085

288_295

516

395.0

Region

G4 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371085

364_369

516

395.0

Region

G5 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371085

42_55

516

395.0

Region

G1 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371095

196_204

502

381.0

Region

G2 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371095

219_228

502

381.0

Region

G3 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371095

288_295

502

381.0

Region

G4 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371095

364_369

502

381.0

Region

G5 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371095

42_55

502

381.0

Region

G1 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371100

1007_1012

1159

1038.0

Region

G5 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371100

685_698

1159

1038.0

Region

G1 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371100

839_847

1159

1038.0

Region

G2 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371100

862_871

1159

1038.0

Region

G3 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371100

931_938

1159

1038.0

Region

G4 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371102

1007_1012

1145

1024.0

Region

G5 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371102

685_698

1145

1024.0

Region

G1 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371102

839_847

1145

1024.0

Region

G2 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371102

862_871

1145

1024.0

Region

G3 motif

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371102

931_938

1145

1024.0

Region

G4 motif

Tgene

SEC63

chr20:57486241

chr6:108214782

ENST00000369002

597_635

761.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SEC63

chr20:57486241

chr6:108214782

ENST00000369002

734_760

761.0

Compositional bias

Note=Asp/Glu-rich (highly acidic)

Tgene

SEC63

chr20:57486241

chr6:108214782

ENST00000369002

104_165

761.0

Domain

Tgene

SEC63

chr20:57486241

chr6:108214782

ENST00000369002

197_541

761.0

Domain

Note=SEC63 1

Tgene

SEC63

chr20:57486241

chr6:108214782

ENST00000369002

637_714

761.0

Domain

Note=SEC63 2

Tgene

SEC63

chr20:57486241

chr6:108214782

ENST00000369002

1_14

761.0

Topological domain

Lumenal

Tgene

SEC63

chr20:57486241

chr6:108214782

ENST00000369002

210_760

761.0

Topological domain

Cytoplasmic

Tgene

SEC63

chr20:57486241

chr6:108214782

ENST00000369002

36_69

761.0

Topological domain

Cytoplasmic

Tgene

SEC63

chr20:57486241

chr6:108214782

ENST00000369002

91_188

761.0

Topological domain

Lumenal

Tgene

SEC63

chr20:57486241

chr6:108214782

ENST00000369002

15_35

761.0

Transmembrane

Helical

Tgene

SEC63

chr20:57486241

chr6:108214782

ENST00000369002

189_209

761.0

Transmembrane

Helical

Tgene

SEC63

chr20:57486241

chr6:108214782

ENST00000369002

70_90

761.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000306120

238_476

626.0

Compositional bias

Pro-rich

Hgene

GNAS

chr20:57486241

chr6:108214782

ENST00000371098

78_142

20.333333333333332

Compositional bias

Glu-rich

Top

Fusion Gene Sequence for GNAS-SEC63

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>33644_33644_1_GNAS-SEC63_GNAS_chr20_57486241_ENST00000265620_SEC63_chr6_108214782_ENST00000369002_length(transcript)=6520nt_BP=1866nt
GGGCGGCGGCGGGGGCCCGGCCGAGGCAATAAGAGCGGCGGCGGCGGCAGCGGCGGCAGCAGCTCCCGCAGCTCCTGCTCTGGTCCGCCT
CGGCCCGGCGGCGGCCATCAGCCCCCTCGGCCTCGGCTCGAGGGGCGGGGAGCTGCGCGCGCCCCTCGGTCCGACCGACACCCTCCCCTT
CCCGCCCGTCCGCGCGCCCCGCGGCCCGCGGCCCGCAGTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCG
CCCGGCGCTGCCCCGGCCCTCCCGGCCCGCGTGAGGCCGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCC
GCCATGGGCTGCCTCGGGAACAGTAAGACCGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAG
CTGCAGAAGGACAAGCAGGTCTACCGGGCCACGCACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAG
ATGAGGATCCTGCATGTTAATGGGTTTAATGGAGATGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATTGAA
ACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTG
ATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAA
CGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGAT
CAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGACGTG
GGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAAC
ATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACC
ATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAA
TTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGATGAG
TTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGT
GTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAG
CCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTCCCT
TCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAAAAG
GAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAA
TGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAATTGGAAGTTCATGAGGCTAAGCCT
GTGCCAGAAAATCACCCACAGTGGGATACAGCAATAGAGGGGGATGAAGACCAGGAGGACAGTGAGGGCTTTGAAGATAGCTTTGAGGAA
GAAGAGGAGGAAGAAGAAGATGATGACTAAGCAGTACTCTGAATGGACCACAGTGTTTGCACATATTTGCAATTTTTTGCTGTTTTGGAA
GTGTATCATAAACCAGAAACAGTACAGAACTGATGTTGAGGGAGGTGTAGTTTTTTTACTCTTGAAATGGGTGCATAATATAACTAGGCA
GTGGCGGTGCCTTGGTACAACCTGAAAAATGTTAAGGCTTATTGAAACCTTTCAAGTAGGGGATGGTACATTTATTTCATCTGCAAATGA
TAATAAATCCTTTGTTATTATAACTGTCCAGAAGTGTGGGCTATGTATTATCTGATCAGTCTATGGTCCCAGTAAAAGTAAAGATGCAGG
AAACACAGTCTGTAAATGAGCGACTTTTCTTTGTTCAGCTTTAGTTTTAGCAAACACCACAAATATGTTTTAAGTAACATCGCTCAAGTT
TAAGTAACATCGCTCAAGTTGATAATCTCTTGATAAGCTCTGTTGTTGACATTTTGCAGTGATACAACAGCTCCACTCATAGATTTAAAC
TTTTATTTTTACTTATCTTGGTCATAAGTTGGCATTCTCTCACATTCCACATGATATAGAGGGCTACGTTTTGGAATTTTCCTTTTCTTA
ATTGCCCAGAGTTATCAGACAGATTATAAAAATGGCTTTTAATGGCTTAAACCATTTCTAAACCTCTATCTTAGCAGATCAATGCAGGAT
CTAATTCTTTTGATAAGTTCTAGCTCTAAAAGTGATAGTGGGACTGTATGTTTTCTGATACTGGTGGCTTATGTTATTAAACCTTTTTTA
AAAAAGGTTCACTCTAAAAGCTGAACTACATCCTTAGTTTTCAGTCTACTTGACTCTATCAGGAGCTTTTTAAGGAAAGTAAGTATAACA
TGCAAAGGAAGCTTTTTTTGTATTCATTTTGGACTCCTGTCAATAAAAATAGAAGTTTGTTGACTCGTTTTATGTTTCAATGGTGTGTGT
CTTTTTACTATCAGGACATAAATAGGGCAATCCACTTCTTTATTTTTCAACTAAAGATTGAATAGTATTGTACATTACTGCTAAAGTGAC
TGCTATTTCTGTATACTGTAGAAAAACCCAGGAGTGAGAGGGATTTCCCCTCATAGTACAACTGGAAGGATAGTGCTTGTAAAGAGTAGA
GATGTGTACATGATGAATCATTGAGGGAGGGTGGATATTTTTATTCCTAGATATGGAGGAAACATAAGTCTGTAGTATTATAAAACTGAT
TGTAATAATTCTTTCCTATCAAAATCTCCATAGGTCAAAATATTGTTGGAATACTAAAATTTGCAACCTTGTTTACTTTAAAAGGTTGCC
ACTTTCAGTGCAGAATACTACCGGCATCTTGTTACTGCAATAGTTGGAAATAAAATGTGAAAATTAGCAAAACCATGAATGGTTTTTTTG
GTTCTAAATTTAAGATGTAATATTTCCTATAAAAGGGTGAAAGCAGTTTCTTTCTCTATAACCTCAATCACCAGTTTAGTGAGAGCCTTT
CTTGGCAGGCAGGAGGCAGTGTCACTGAGGATTTTTTTCATTTACTTCATTGTACAAGTAGGAGGGTGGGTTTAATTTTCAAATCAGGTT
CTGCTGTGAAGCACCAGTGTCTTGAGGCAGCTACTGATTACCTAAGTGTGGTGGCAGGGGGTAAGCCAGCTGGTGTCAAGTGAAAGGAGG
GATTAGAGAAAACAGGTGTGGCACGAAGGCAAGGAAACTGAGCAGACAAGACAGAACAATGTGTAGAATGCATATTTCCTAGTTTTCTTG
AAAGATTTCAAGAAAAGTTGTTTTTTTTTTTCTAGTGGCTACTTTGCCTTAAAGAGGCTTTATAAGTTCATTCACACAGCTGGCTTCTCT
GGTTTTAAGATTCTGGAGAGGATGATAACCTAGTAACACCACAGTGCTTAAAAAAAAAAAAAAAAAAAAAACTACCATCACCAGAAAATT
CCACCAGTTTGTTTTCCTTTTCTCTTTGTGTGATGTGTATGTACTTCCCAACTAAGTAAAATAAAATTTCCTCTAGTGAGTGCTTTAGGT
AACCTCTTTCCATATGGCAGTAGTGAAAGAACTGAGCCTTCAGTTGATAGTTCTTCTCTCTCCAGCAAGTCGCTAAACTCCACATCCCTT
CGTTTTTCCTCTGGAATGAGAATAACAAACTATCCTAGTTTGCATTTAATCTAATGGAAACTTGAGCAAAGTTTCAATTTTCTTCCTATA
AAGAAACTGACATTTTGTCAACAATTGATGAGCCTATAGATCATACAGTGTATAGGAAGTGAAATTGAAACAGTTAAATTATGTGATATT
TTTCTCTAATTGGTAAAGTACCTATTAAAATACAGCTGTTCATGAGGAGACTTACCACAATTCAAAGTGTAGCAGTTGTGTATTTTAGCA
TTATAATATTTGATTGAGGCCCTGAGGTGTTAATATCTCAATCTCAGAGTTAGATGTTCATGTCCTTTTTGAATTTTTTAAACATTTTTC
ATAATTTTTTTTTTAAGTTAGGGAGCACATTGAGTGAAGTTCTCTGTGTAGAACAATACCTTCTGCTCTGCTTCTCCCAGCTTTCACTGA
GGGCTGGAAAAGGACAGGCCTGTCCAGCTGTACTGTCCCACTGTGTATGGGGAAGCTCAGGCTCTGGTGGAAGCAGGGGGCGTGGATGTC
AAACAACTGATGTGGAAACAGGGAGGGAGAGATATAATGAGGCTCTCTAGGCATGTTATTTTTGACCACAAGTTTTGTTCAGTTTGCTTC
AGCCAATCCAAACCATATACTAGAGTGTTCTGTAGTCACAATTCTTATTTCAAATGTAATTCAGCACCTTACATAATTTTTGAGAGGTTG
TCATTCATCACATATTTACTGAGTTTCTATGTGCCAGGCTCTGTGACTGGATACTGGAGCTATCAAAATGAAAAAAATAGTGTTAAGAAC
TCACTCGCTGGTGTTAGAGCAGGTAGATGAGTGGCAATCCATTTAAATCCATTTGCCTTGGCTATTATTTGGAATGCCTTTTTTTTTTTT
TAGTCTATCTACTGTAGGCAGAAGAATTATTTCTTTAGGGGCTAGCTGTTTATTTTGCTGGCCTTTTTTTCTCTCTTTCTCTTTTTCTTC
TTAAGACGGAGTCTCGCTCTGTCCTCCAGGCTGGAGGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCCGCCTCCCAGCTTCAAGC
GATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTGCAGGTGCATGCCACCACACCCAGCTAATTTTTTAATTTTTAGTAGAGATGGGA
TTTTGCCACGTTGTCCAGCCTGGTCTCGAACTCCTGGCCTCAAGTGATCAGCCCTCCTCAGCCTCCCAAAGTGCTGGCATTACAGGCATG
AGCCACTGCGCCCAGCCTGTTGGGTTTTTTTGGAAAAAAAACAAAAACAACAAATCATCATCCTTTCCTTTAAAATGTTTTTTTTTTTTT
AAGAAACAATTTTCCCACAAACGGTCTGATTTAACTCCATGAAATCCTCTATTTAGACTGCCTTAAAGTGAAATAACTGTTGGTGAACCA
TAACATTTTGCCAGCTGTGTAGTGATTAGTCCAAATATGTCTCAAGAAGTTAGCACCAAGCATTCTCATCCATTTAAACTTGATGCTAGG
GCTATTTTGCAAAACTTAAAAAGATGCGATCTTGTACATATTTCTGTAACCTGAGCTGAAAACCCAAATAACAATCATTGACATACTTTA
GGGCTATTGTTTCAGGTGGGGGTGTATACATCCCAGGGGCGTGGAGATGATCAATCCATTGAGGAAGTATTAAGATGATTATTTGTATTT
AATCTCATCCTTTTAAATTTCTATTTTTGTGTGTTTTATAATGTACATAATATATTGTACAATTGTACACTTCTATTATTTATAAATAAA
CATTTATTGGTGCATTAAGTAGAGCTGAAGTTTCCTGCACCAGGCAAGCCTGGAAATTATCAGTATACTGTGTTTCTGAGATCAGACTCC
TATATGGGTTTGGATCAGATTAAACCATTGAAGGAAAAACAAGAATGGTGGTGGCTTTACATTGCAGATAGGAAGGAGCAGACATTAATA
TCCATGCCATATCATGTGTGTACGCTGAAAGATACAGAGGAGGAGTGGCAAGAATTACAACAAAGCATACAGCGAAAAGAGAGAGCTCTA
TTGGAAACCAAATCAAAAATAACACATCCTGTGTATAGCCTTTACTTTCCTGAGGAAGCTGCAGTAAAGGAAGATGAAGAAGAAGTTTCA
GATAAGGGCAGTGATTCTGAAGAAGAAGAAACCAATAGAGATTCCCAAAGTGAGAAAGATGATGGTAGTGACAGAGACTCTGATAGAGAG
CAAGATGAAAAACAAAACAAAGATGATGAAGCAAAAAAAAAAGAAACCTTTAAAAAAAAAACCTACACCTGTGCTATTACCACAGTCAAA

>33644_33644_1_GNAS-SEC63_GNAS_chr20_57486241_ENST00000265620_SEC63_chr6_108214782_ENST00000369002_length(amino acids)=506AA_BP=
MGVPFLEQLVLTKVHALNDVTAVVEHTADVLSVHSAGEMRVAVVTPISTGSADPQKLISNEVLGPGHAWVLSGLGSSILRSSVASKFWKV
VLNLRFPSKDFLSEQILLVEEQDHRDGAQPSVVPDALEEVQSLLQAVGLVVLPDDHVVAAAGHHEDDGSHIVEALDPLAAFIALATHVKH
VEVDFVHLELGLKDSRSQDTAAKQVLIARHIVSLLDHVDLVQEVLGTVNQLVLVGAFVAGTHSFILPQSLGMLIEFGREVKVRHVHHTQD
VVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLISIKPINMQDPHLLHNGAFTRFSSTQQQQAVRGPVDLLVLLQLLLD
LFVGLTLRLLLVALVLGLTVPEAAHGGGGGGGARPGCGGGGRGRPHAGREGRGSAGRAGRARARLLGKERAGRTAGRGPRGARTGGKGRV

--------------------------------------------------------------
>33644_33644_2_GNAS-SEC63_GNAS_chr20_57486241_ENST00000306090_SEC63_chr6_108214782_ENST00000369002_length(transcript)=6296nt_BP=1642nt
CAGCGGCGGCAGCAGCTCCCGCAGCTCCTGCTCTGGTCCGCCTCGGCCCGGCGGCGGCCATCAGCCCCCTCGGCCTCGGCTCGAGGGGCG
GGGAGCTGCGCGCGCCCCTCGGTCCGACCGACACCCTCCCCTTCCCGCCCCCATGGGCTGCCTCGGGAACAGTAAGACCGAGGACCAGCG
CAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGCCACGCACCGCCT
GCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGACAGTGA
GAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGT
GGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTA
TGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTA
CTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAAT
CTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTG
CTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCA
GGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCT
CGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGA
GCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCA
CTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCA
CCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTA
CAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCA
GCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAA
AAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATC
AAAATAAAAATTAAATGTGAGCTTGGAAGTTCATGAGGCTAAGCCTGTGCCAGAAAATCACCCACAGTGGGATACAGCAATAGAGGGGGA
TGAAGACCAGGAGGACAGTGAGGGCTTTGAAGATAGCTTTGAGGAAGAAGAGGAGGAAGAAGAAGATGATGACTAAGCAGTACTCTGAAT
GGACCACAGTGTTTGCACATATTTGCAATTTTTTGCTGTTTTGGAAGTGTATCATAAACCAGAAACAGTACAGAACTGATGTTGAGGGAG
GTGTAGTTTTTTTACTCTTGAAATGGGTGCATAATATAACTAGGCAGTGGCGGTGCCTTGGTACAACCTGAAAAATGTTAAGGCTTATTG
AAACCTTTCAAGTAGGGGATGGTACATTTATTTCATCTGCAAATGATAATAAATCCTTTGTTATTATAACTGTCCAGAAGTGTGGGCTAT
GTATTATCTGATCAGTCTATGGTCCCAGTAAAAGTAAAGATGCAGGAAACACAGTCTGTAAATGAGCGACTTTTCTTTGTTCAGCTTTAG
TTTTAGCAAACACCACAAATATGTTTTAAGTAACATCGCTCAAGTTTAAGTAACATCGCTCAAGTTGATAATCTCTTGATAAGCTCTGTT
GTTGACATTTTGCAGTGATACAACAGCTCCACTCATAGATTTAAACTTTTATTTTTACTTATCTTGGTCATAAGTTGGCATTCTCTCACA
TTCCACATGATATAGAGGGCTACGTTTTGGAATTTTCCTTTTCTTAATTGCCCAGAGTTATCAGACAGATTATAAAAATGGCTTTTAATG
GCTTAAACCATTTCTAAACCTCTATCTTAGCAGATCAATGCAGGATCTAATTCTTTTGATAAGTTCTAGCTCTAAAAGTGATAGTGGGAC
TGTATGTTTTCTGATACTGGTGGCTTATGTTATTAAACCTTTTTTAAAAAAGGTTCACTCTAAAAGCTGAACTACATCCTTAGTTTTCAG
TCTACTTGACTCTATCAGGAGCTTTTTAAGGAAAGTAAGTATAACATGCAAAGGAAGCTTTTTTTGTATTCATTTTGGACTCCTGTCAAT
AAAAATAGAAGTTTGTTGACTCGTTTTATGTTTCAATGGTGTGTGTCTTTTTACTATCAGGACATAAATAGGGCAATCCACTTCTTTATT
TTTCAACTAAAGATTGAATAGTATTGTACATTACTGCTAAAGTGACTGCTATTTCTGTATACTGTAGAAAAACCCAGGAGTGAGAGGGAT
TTCCCCTCATAGTACAACTGGAAGGATAGTGCTTGTAAAGAGTAGAGATGTGTACATGATGAATCATTGAGGGAGGGTGGATATTTTTAT
TCCTAGATATGGAGGAAACATAAGTCTGTAGTATTATAAAACTGATTGTAATAATTCTTTCCTATCAAAATCTCCATAGGTCAAAATATT
GTTGGAATACTAAAATTTGCAACCTTGTTTACTTTAAAAGGTTGCCACTTTCAGTGCAGAATACTACCGGCATCTTGTTACTGCAATAGT
TGGAAATAAAATGTGAAAATTAGCAAAACCATGAATGGTTTTTTTGGTTCTAAATTTAAGATGTAATATTTCCTATAAAAGGGTGAAAGC
AGTTTCTTTCTCTATAACCTCAATCACCAGTTTAGTGAGAGCCTTTCTTGGCAGGCAGGAGGCAGTGTCACTGAGGATTTTTTTCATTTA
CTTCATTGTACAAGTAGGAGGGTGGGTTTAATTTTCAAATCAGGTTCTGCTGTGAAGCACCAGTGTCTTGAGGCAGCTACTGATTACCTA
AGTGTGGTGGCAGGGGGTAAGCCAGCTGGTGTCAAGTGAAAGGAGGGATTAGAGAAAACAGGTGTGGCACGAAGGCAAGGAAACTGAGCA
GACAAGACAGAACAATGTGTAGAATGCATATTTCCTAGTTTTCTTGAAAGATTTCAAGAAAAGTTGTTTTTTTTTTTCTAGTGGCTACTT
TGCCTTAAAGAGGCTTTATAAGTTCATTCACACAGCTGGCTTCTCTGGTTTTAAGATTCTGGAGAGGATGATAACCTAGTAACACCACAG
TGCTTAAAAAAAAAAAAAAAAAAAAAACTACCATCACCAGAAAATTCCACCAGTTTGTTTTCCTTTTCTCTTTGTGTGATGTGTATGTAC
TTCCCAACTAAGTAAAATAAAATTTCCTCTAGTGAGTGCTTTAGGTAACCTCTTTCCATATGGCAGTAGTGAAAGAACTGAGCCTTCAGT
TGATAGTTCTTCTCTCTCCAGCAAGTCGCTAAACTCCACATCCCTTCGTTTTTCCTCTGGAATGAGAATAACAAACTATCCTAGTTTGCA
TTTAATCTAATGGAAACTTGAGCAAAGTTTCAATTTTCTTCCTATAAAGAAACTGACATTTTGTCAACAATTGATGAGCCTATAGATCAT
ACAGTGTATAGGAAGTGAAATTGAAACAGTTAAATTATGTGATATTTTTCTCTAATTGGTAAAGTACCTATTAAAATACAGCTGTTCATG
AGGAGACTTACCACAATTCAAAGTGTAGCAGTTGTGTATTTTAGCATTATAATATTTGATTGAGGCCCTGAGGTGTTAATATCTCAATCT
CAGAGTTAGATGTTCATGTCCTTTTTGAATTTTTTAAACATTTTTCATAATTTTTTTTTTAAGTTAGGGAGCACATTGAGTGAAGTTCTC
TGTGTAGAACAATACCTTCTGCTCTGCTTCTCCCAGCTTTCACTGAGGGCTGGAAAAGGACAGGCCTGTCCAGCTGTACTGTCCCACTGT
GTATGGGGAAGCTCAGGCTCTGGTGGAAGCAGGGGGCGTGGATGTCAAACAACTGATGTGGAAACAGGGAGGGAGAGATATAATGAGGCT
CTCTAGGCATGTTATTTTTGACCACAAGTTTTGTTCAGTTTGCTTCAGCCAATCCAAACCATATACTAGAGTGTTCTGTAGTCACAATTC
TTATTTCAAATGTAATTCAGCACCTTACATAATTTTTGAGAGGTTGTCATTCATCACATATTTACTGAGTTTCTATGTGCCAGGCTCTGT
GACTGGATACTGGAGCTATCAAAATGAAAAAAATAGTGTTAAGAACTCACTCGCTGGTGTTAGAGCAGGTAGATGAGTGGCAATCCATTT
AAATCCATTTGCCTTGGCTATTATTTGGAATGCCTTTTTTTTTTTTTAGTCTATCTACTGTAGGCAGAAGAATTATTTCTTTAGGGGCTA
GCTGTTTATTTTGCTGGCCTTTTTTTCTCTCTTTCTCTTTTTCTTCTTAAGACGGAGTCTCGCTCTGTCCTCCAGGCTGGAGGAGTGCAG
TGGCACGATCTCAGCTCACTGCAACCTCCGCCTCCCAGCTTCAAGCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTGCAGGTGC
ATGCCACCACACCCAGCTAATTTTTTAATTTTTAGTAGAGATGGGATTTTGCCACGTTGTCCAGCCTGGTCTCGAACTCCTGGCCTCAAG
TGATCAGCCCTCCTCAGCCTCCCAAAGTGCTGGCATTACAGGCATGAGCCACTGCGCCCAGCCTGTTGGGTTTTTTTGGAAAAAAAACAA
AAACAACAAATCATCATCCTTTCCTTTAAAATGTTTTTTTTTTTTTAAGAAACAATTTTCCCACAAACGGTCTGATTTAACTCCATGAAA
TCCTCTATTTAGACTGCCTTAAAGTGAAATAACTGTTGGTGAACCATAACATTTTGCCAGCTGTGTAGTGATTAGTCCAAATATGTCTCA
AGAAGTTAGCACCAAGCATTCTCATCCATTTAAACTTGATGCTAGGGCTATTTTGCAAAACTTAAAAAGATGCGATCTTGTACATATTTC
TGTAACCTGAGCTGAAAACCCAAATAACAATCATTGACATACTTTAGGGCTATTGTTTCAGGTGGGGGTGTATACATCCCAGGGGCGTGG
AGATGATCAATCCATTGAGGAAGTATTAAGATGATTATTTGTATTTAATCTCATCCTTTTAAATTTCTATTTTTGTGTGTTTTATAATGT
ACATAATATATTGTACAATTGTACACTTCTATTATTTATAAATAAACATTTATTGGTGCATTAAGTAGAGCTGAAGTTTCCTGCACCAGG
CAAGCCTGGAAATTATCAGTATACTGTGTTTCTGAGATCAGACTCCTATATGGGTTTGGATCAGATTAAACCATTGAAGGAAAAACAAGA
ATGGTGGTGGCTTTACATTGCAGATAGGAAGGAGCAGACATTAATATCCATGCCATATCATGTGTGTACGCTGAAAGATACAGAGGAGGA
GTGGCAAGAATTACAACAAAGCATACAGCGAAAAGAGAGAGCTCTATTGGAAACCAAATCAAAAATAACACATCCTGTGTATAGCCTTTA
CTTTCCTGAGGAAGCTGCAGTAAAGGAAGATGAAGAAGAAGTTTCAGATAAGGGCAGTGATTCTGAAGAAGAAGAAACCAATAGAGATTC
CCAAAGTGAGAAAGATGATGGTAGTGACAGAGACTCTGATAGAGAGCAAGATGAAAAACAAAACAAAGATGATGAAGCAAAAAAAAAAGA

>33644_33644_2_GNAS-SEC63_GNAS_chr20_57486241_ENST00000306090_SEC63_chr6_108214782_ENST00000369002_length(amino acids)=433AA_BP=
MGVPFLEQLVLTKVHALNDVTAVVEHTADVLSVHSAGEMRVAVVTPISTGSADPQKLISNEVLGPGHAWVLSGLGSSILRSSVASKFWKV
VLNLRFPSKDFLSEQILLVEEQDHRDGAQPSVVPDALEEVQSLLQAVGLVVLPDDHVVAAAGHHEDDGSHIVEALDPLAAFIALATHVKH
VEVDFVHLELGLKDSRSQDTAAKQVLIARHIVSLLDHVDLVQEVLGTVNQLVLVGAFVAGTHSFILPQSLGMLIEFGREVKVRHVHHTQD
VVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLTVSIKPINMQDPHLLHNGAFTRFSSTQQQQAVRGPVDLLVLLQLLL

--------------------------------------------------------------
>33644_33644_3_GNAS-SEC63_GNAS_chr20_57486241_ENST00000354359_SEC63_chr6_108214782_ENST00000369002_length(transcript)=6629nt_BP=1975nt
TCGCCGCCGCCGCCTCCTCCTCCCCCCGCCTCCCCCCGCCCGCCGCGGCGCTTTTGGCTCGGGGCGGCGGCGGGGGCCCGGCCGAGGCAA
TAAGAGCGGCGGCGGCGGCAGCGGCGGCAGCAGCTCCCGCAGCTCCTGCTCTGGTCCGCCTCGGCCCGGCGGCGGCCATCAGCCCCCTCG
GCCTCGGCTCGAGGGGCGGGGAGCTGCGCGCGCCCCTCGGTCCGACCGACACCCTCCCCTTCCCGCCCGTCCGCGCGCCCCGCGGCCCGC
GGCCCGCAGTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCGCCCGGCGCTGCCCCGGCCCTCCCGGCCCG
CGTGAGGCCGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGAC
CGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGC
CACGCACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAA
TGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGCAGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAA
CCTGAAAGAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGT
GGACTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGG
AGTGCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGC
TGACTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAA
CTTCCACATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGT
GGCCAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAA
CAACAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGAT
TGAGGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAA
GTACTTCATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGA
CACTGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAA
CCCCCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATT
AACAAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTA
AGGCGGCCTACAGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAA
ATGAAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAATTGGA
AGTTCATGAGGCTAAGCCTGTGCCAGAAAATCACCCACAGTGGGATACAGCAATAGAGGGGGATGAAGACCAGGAGGACAGTGAGGGCTT
TGAAGATAGCTTTGAGGAAGAAGAGGAGGAAGAAGAAGATGATGACTAAGCAGTACTCTGAATGGACCACAGTGTTTGCACATATTTGCA
ATTTTTTGCTGTTTTGGAAGTGTATCATAAACCAGAAACAGTACAGAACTGATGTTGAGGGAGGTGTAGTTTTTTTACTCTTGAAATGGG
TGCATAATATAACTAGGCAGTGGCGGTGCCTTGGTACAACCTGAAAAATGTTAAGGCTTATTGAAACCTTTCAAGTAGGGGATGGTACAT
TTATTTCATCTGCAAATGATAATAAATCCTTTGTTATTATAACTGTCCAGAAGTGTGGGCTATGTATTATCTGATCAGTCTATGGTCCCA
GTAAAAGTAAAGATGCAGGAAACACAGTCTGTAAATGAGCGACTTTTCTTTGTTCAGCTTTAGTTTTAGCAAACACCACAAATATGTTTT
AAGTAACATCGCTCAAGTTTAAGTAACATCGCTCAAGTTGATAATCTCTTGATAAGCTCTGTTGTTGACATTTTGCAGTGATACAACAGC
TCCACTCATAGATTTAAACTTTTATTTTTACTTATCTTGGTCATAAGTTGGCATTCTCTCACATTCCACATGATATAGAGGGCTACGTTT
TGGAATTTTCCTTTTCTTAATTGCCCAGAGTTATCAGACAGATTATAAAAATGGCTTTTAATGGCTTAAACCATTTCTAAACCTCTATCT
TAGCAGATCAATGCAGGATCTAATTCTTTTGATAAGTTCTAGCTCTAAAAGTGATAGTGGGACTGTATGTTTTCTGATACTGGTGGCTTA
TGTTATTAAACCTTTTTTAAAAAAGGTTCACTCTAAAAGCTGAACTACATCCTTAGTTTTCAGTCTACTTGACTCTATCAGGAGCTTTTT
AAGGAAAGTAAGTATAACATGCAAAGGAAGCTTTTTTTGTATTCATTTTGGACTCCTGTCAATAAAAATAGAAGTTTGTTGACTCGTTTT
ATGTTTCAATGGTGTGTGTCTTTTTACTATCAGGACATAAATAGGGCAATCCACTTCTTTATTTTTCAACTAAAGATTGAATAGTATTGT
ACATTACTGCTAAAGTGACTGCTATTTCTGTATACTGTAGAAAAACCCAGGAGTGAGAGGGATTTCCCCTCATAGTACAACTGGAAGGAT
AGTGCTTGTAAAGAGTAGAGATGTGTACATGATGAATCATTGAGGGAGGGTGGATATTTTTATTCCTAGATATGGAGGAAACATAAGTCT
GTAGTATTATAAAACTGATTGTAATAATTCTTTCCTATCAAAATCTCCATAGGTCAAAATATTGTTGGAATACTAAAATTTGCAACCTTG
TTTACTTTAAAAGGTTGCCACTTTCAGTGCAGAATACTACCGGCATCTTGTTACTGCAATAGTTGGAAATAAAATGTGAAAATTAGCAAA
ACCATGAATGGTTTTTTTGGTTCTAAATTTAAGATGTAATATTTCCTATAAAAGGGTGAAAGCAGTTTCTTTCTCTATAACCTCAATCAC
CAGTTTAGTGAGAGCCTTTCTTGGCAGGCAGGAGGCAGTGTCACTGAGGATTTTTTTCATTTACTTCATTGTACAAGTAGGAGGGTGGGT
TTAATTTTCAAATCAGGTTCTGCTGTGAAGCACCAGTGTCTTGAGGCAGCTACTGATTACCTAAGTGTGGTGGCAGGGGGTAAGCCAGCT
GGTGTCAAGTGAAAGGAGGGATTAGAGAAAACAGGTGTGGCACGAAGGCAAGGAAACTGAGCAGACAAGACAGAACAATGTGTAGAATGC
ATATTTCCTAGTTTTCTTGAAAGATTTCAAGAAAAGTTGTTTTTTTTTTTCTAGTGGCTACTTTGCCTTAAAGAGGCTTTATAAGTTCAT
TCACACAGCTGGCTTCTCTGGTTTTAAGATTCTGGAGAGGATGATAACCTAGTAACACCACAGTGCTTAAAAAAAAAAAAAAAAAAAAAA
CTACCATCACCAGAAAATTCCACCAGTTTGTTTTCCTTTTCTCTTTGTGTGATGTGTATGTACTTCCCAACTAAGTAAAATAAAATTTCC
TCTAGTGAGTGCTTTAGGTAACCTCTTTCCATATGGCAGTAGTGAAAGAACTGAGCCTTCAGTTGATAGTTCTTCTCTCTCCAGCAAGTC
GCTAAACTCCACATCCCTTCGTTTTTCCTCTGGAATGAGAATAACAAACTATCCTAGTTTGCATTTAATCTAATGGAAACTTGAGCAAAG
TTTCAATTTTCTTCCTATAAAGAAACTGACATTTTGTCAACAATTGATGAGCCTATAGATCATACAGTGTATAGGAAGTGAAATTGAAAC
AGTTAAATTATGTGATATTTTTCTCTAATTGGTAAAGTACCTATTAAAATACAGCTGTTCATGAGGAGACTTACCACAATTCAAAGTGTA
GCAGTTGTGTATTTTAGCATTATAATATTTGATTGAGGCCCTGAGGTGTTAATATCTCAATCTCAGAGTTAGATGTTCATGTCCTTTTTG
AATTTTTTAAACATTTTTCATAATTTTTTTTTTAAGTTAGGGAGCACATTGAGTGAAGTTCTCTGTGTAGAACAATACCTTCTGCTCTGC
TTCTCCCAGCTTTCACTGAGGGCTGGAAAAGGACAGGCCTGTCCAGCTGTACTGTCCCACTGTGTATGGGGAAGCTCAGGCTCTGGTGGA
AGCAGGGGGCGTGGATGTCAAACAACTGATGTGGAAACAGGGAGGGAGAGATATAATGAGGCTCTCTAGGCATGTTATTTTTGACCACAA
GTTTTGTTCAGTTTGCTTCAGCCAATCCAAACCATATACTAGAGTGTTCTGTAGTCACAATTCTTATTTCAAATGTAATTCAGCACCTTA
CATAATTTTTGAGAGGTTGTCATTCATCACATATTTACTGAGTTTCTATGTGCCAGGCTCTGTGACTGGATACTGGAGCTATCAAAATGA
AAAAAATAGTGTTAAGAACTCACTCGCTGGTGTTAGAGCAGGTAGATGAGTGGCAATCCATTTAAATCCATTTGCCTTGGCTATTATTTG
GAATGCCTTTTTTTTTTTTTAGTCTATCTACTGTAGGCAGAAGAATTATTTCTTTAGGGGCTAGCTGTTTATTTTGCTGGCCTTTTTTTC
TCTCTTTCTCTTTTTCTTCTTAAGACGGAGTCTCGCTCTGTCCTCCAGGCTGGAGGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCT
CCGCCTCCCAGCTTCAAGCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTGCAGGTGCATGCCACCACACCCAGCTAATTTTTTA
ATTTTTAGTAGAGATGGGATTTTGCCACGTTGTCCAGCCTGGTCTCGAACTCCTGGCCTCAAGTGATCAGCCCTCCTCAGCCTCCCAAAG
TGCTGGCATTACAGGCATGAGCCACTGCGCCCAGCCTGTTGGGTTTTTTTGGAAAAAAAACAAAAACAACAAATCATCATCCTTTCCTTT
AAAATGTTTTTTTTTTTTTAAGAAACAATTTTCCCACAAACGGTCTGATTTAACTCCATGAAATCCTCTATTTAGACTGCCTTAAAGTGA
AATAACTGTTGGTGAACCATAACATTTTGCCAGCTGTGTAGTGATTAGTCCAAATATGTCTCAAGAAGTTAGCACCAAGCATTCTCATCC
ATTTAAACTTGATGCTAGGGCTATTTTGCAAAACTTAAAAAGATGCGATCTTGTACATATTTCTGTAACCTGAGCTGAAAACCCAAATAA
CAATCATTGACATACTTTAGGGCTATTGTTTCAGGTGGGGGTGTATACATCCCAGGGGCGTGGAGATGATCAATCCATTGAGGAAGTATT
AAGATGATTATTTGTATTTAATCTCATCCTTTTAAATTTCTATTTTTGTGTGTTTTATAATGTACATAATATATTGTACAATTGTACACT
TCTATTATTTATAAATAAACATTTATTGGTGCATTAAGTAGAGCTGAAGTTTCCTGCACCAGGCAAGCCTGGAAATTATCAGTATACTGT
GTTTCTGAGATCAGACTCCTATATGGGTTTGGATCAGATTAAACCATTGAAGGAAAAACAAGAATGGTGGTGGCTTTACATTGCAGATAG
GAAGGAGCAGACATTAATATCCATGCCATATCATGTGTGTACGCTGAAAGATACAGAGGAGGAGTGGCAAGAATTACAACAAAGCATACA
GCGAAAAGAGAGAGCTCTATTGGAAACCAAATCAAAAATAACACATCCTGTGTATAGCCTTTACTTTCCTGAGGAAGCTGCAGTAAAGGA
AGATGAAGAAGAAGTTTCAGATAAGGGCAGTGATTCTGAAGAAGAAGAAACCAATAGAGATTCCCAAAGTGAGAAAGATGATGGTAGTGA
CAGAGACTCTGATAGAGAGCAAGATGAAAAACAAAACAAAGATGATGAAGCAAAAAAAAAAGAAACCTTTAAAAAAAAAACCTACACCTG

>33644_33644_3_GNAS-SEC63_GNAS_chr20_57486241_ENST00000354359_SEC63_chr6_108214782_ENST00000369002_length(amino acids)=542AA_BP=
MGVPFLEQLVLTKVHALNDVTAVVEHTADVLSVHSAGEMRVAVVTPISTGSADPQKLISNEVLGPGHAWVLSGLGSSILRSSVASKFWKV
VLNLRFPSKDFLSEQILLVEEQDHRDGAQPSVVPDALEEVQSLLQAVGLVVLPDDHVVAAAGHHEDDGSHIVEALDPLAAFIALATHVKH
VEVDFVHLELGLKDSRSQDTAAKQVLIARHIVSLLDHVDLVQEVLGTVNQLVLVGAFVAGTHSFILPQSLGMLIEFGREVKVRHVHHTQD
VVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLTAIAVAPCSLRVLFAALSIKPINMQDPHLLHNGAFTRFSSTQQQQA
VRGPVDLLVLLQLLLDLFVGLTLRLLLVALVLGLTVPEAAHGGGGGGGARPGCGGGGRGRPHAGREGRGSAGRAGRARARLLGKERAGRT
AGRGPRGARTGGKGRVSVGPRGARSSPPLEPRPRGLMAAAGPRRTRAGAAGAAAAAAAAAALIASAGPPPPPRAKSAAAGGGRRGEEEAA

--------------------------------------------------------------
>33644_33644_4_GNAS-SEC63_GNAS_chr20_57486241_ENST00000371085_SEC63_chr6_108214782_ENST00000369002_length(transcript)=6626nt_BP=1972nt
TCGCCGCCGCCGCCTCCTCCTCCCCCCGCCTCCCCCCGCCCGCCGCGGCGCTTTTGGCTCGGGGCGGCGGCGGGGGCCCGGCCGAGGCAA
TAAGAGCGGCGGCGGCGGCAGCGGCGGCAGCAGCTCCCGCAGCTCCTGCTCTGGTCCGCCTCGGCCCGGCGGCGGCCATCAGCCCCCTCG
GCCTCGGCTCGAGGGGCGGGGAGCTGCGCGCGCCCCTCGGTCCGACCGACACCCTCCCCTTCCCGCCCGTCCGCGCGCCCCGCGGCCCGC
GGCCCGCAGTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCGCCCGGCGCTGCCCCGGCCCTCCCGGCCCG
CGTGAGGCCGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGAC
CGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGC
CACGCACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAA
TGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCT
GAAAGAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGA
CTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGT
GCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGA
CTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTT
CCACATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGC
CAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAA
CAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGA
GGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTA
CTTCATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACAC
TGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCC
CCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATTAAC
AAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGG
CGGCCTACAGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATG
AAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAATTGGAAGT
TCATGAGGCTAAGCCTGTGCCAGAAAATCACCCACAGTGGGATACAGCAATAGAGGGGGATGAAGACCAGGAGGACAGTGAGGGCTTTGA
AGATAGCTTTGAGGAAGAAGAGGAGGAAGAAGAAGATGATGACTAAGCAGTACTCTGAATGGACCACAGTGTTTGCACATATTTGCAATT
TTTTGCTGTTTTGGAAGTGTATCATAAACCAGAAACAGTACAGAACTGATGTTGAGGGAGGTGTAGTTTTTTTACTCTTGAAATGGGTGC
ATAATATAACTAGGCAGTGGCGGTGCCTTGGTACAACCTGAAAAATGTTAAGGCTTATTGAAACCTTTCAAGTAGGGGATGGTACATTTA
TTTCATCTGCAAATGATAATAAATCCTTTGTTATTATAACTGTCCAGAAGTGTGGGCTATGTATTATCTGATCAGTCTATGGTCCCAGTA
AAAGTAAAGATGCAGGAAACACAGTCTGTAAATGAGCGACTTTTCTTTGTTCAGCTTTAGTTTTAGCAAACACCACAAATATGTTTTAAG
TAACATCGCTCAAGTTTAAGTAACATCGCTCAAGTTGATAATCTCTTGATAAGCTCTGTTGTTGACATTTTGCAGTGATACAACAGCTCC
ACTCATAGATTTAAACTTTTATTTTTACTTATCTTGGTCATAAGTTGGCATTCTCTCACATTCCACATGATATAGAGGGCTACGTTTTGG
AATTTTCCTTTTCTTAATTGCCCAGAGTTATCAGACAGATTATAAAAATGGCTTTTAATGGCTTAAACCATTTCTAAACCTCTATCTTAG
CAGATCAATGCAGGATCTAATTCTTTTGATAAGTTCTAGCTCTAAAAGTGATAGTGGGACTGTATGTTTTCTGATACTGGTGGCTTATGT
TATTAAACCTTTTTTAAAAAAGGTTCACTCTAAAAGCTGAACTACATCCTTAGTTTTCAGTCTACTTGACTCTATCAGGAGCTTTTTAAG
GAAAGTAAGTATAACATGCAAAGGAAGCTTTTTTTGTATTCATTTTGGACTCCTGTCAATAAAAATAGAAGTTTGTTGACTCGTTTTATG
TTTCAATGGTGTGTGTCTTTTTACTATCAGGACATAAATAGGGCAATCCACTTCTTTATTTTTCAACTAAAGATTGAATAGTATTGTACA
TTACTGCTAAAGTGACTGCTATTTCTGTATACTGTAGAAAAACCCAGGAGTGAGAGGGATTTCCCCTCATAGTACAACTGGAAGGATAGT
GCTTGTAAAGAGTAGAGATGTGTACATGATGAATCATTGAGGGAGGGTGGATATTTTTATTCCTAGATATGGAGGAAACATAAGTCTGTA
GTATTATAAAACTGATTGTAATAATTCTTTCCTATCAAAATCTCCATAGGTCAAAATATTGTTGGAATACTAAAATTTGCAACCTTGTTT
ACTTTAAAAGGTTGCCACTTTCAGTGCAGAATACTACCGGCATCTTGTTACTGCAATAGTTGGAAATAAAATGTGAAAATTAGCAAAACC
ATGAATGGTTTTTTTGGTTCTAAATTTAAGATGTAATATTTCCTATAAAAGGGTGAAAGCAGTTTCTTTCTCTATAACCTCAATCACCAG
TTTAGTGAGAGCCTTTCTTGGCAGGCAGGAGGCAGTGTCACTGAGGATTTTTTTCATTTACTTCATTGTACAAGTAGGAGGGTGGGTTTA
ATTTTCAAATCAGGTTCTGCTGTGAAGCACCAGTGTCTTGAGGCAGCTACTGATTACCTAAGTGTGGTGGCAGGGGGTAAGCCAGCTGGT
GTCAAGTGAAAGGAGGGATTAGAGAAAACAGGTGTGGCACGAAGGCAAGGAAACTGAGCAGACAAGACAGAACAATGTGTAGAATGCATA
TTTCCTAGTTTTCTTGAAAGATTTCAAGAAAAGTTGTTTTTTTTTTTCTAGTGGCTACTTTGCCTTAAAGAGGCTTTATAAGTTCATTCA
CACAGCTGGCTTCTCTGGTTTTAAGATTCTGGAGAGGATGATAACCTAGTAACACCACAGTGCTTAAAAAAAAAAAAAAAAAAAAAACTA
CCATCACCAGAAAATTCCACCAGTTTGTTTTCCTTTTCTCTTTGTGTGATGTGTATGTACTTCCCAACTAAGTAAAATAAAATTTCCTCT
AGTGAGTGCTTTAGGTAACCTCTTTCCATATGGCAGTAGTGAAAGAACTGAGCCTTCAGTTGATAGTTCTTCTCTCTCCAGCAAGTCGCT
AAACTCCACATCCCTTCGTTTTTCCTCTGGAATGAGAATAACAAACTATCCTAGTTTGCATTTAATCTAATGGAAACTTGAGCAAAGTTT
CAATTTTCTTCCTATAAAGAAACTGACATTTTGTCAACAATTGATGAGCCTATAGATCATACAGTGTATAGGAAGTGAAATTGAAACAGT
TAAATTATGTGATATTTTTCTCTAATTGGTAAAGTACCTATTAAAATACAGCTGTTCATGAGGAGACTTACCACAATTCAAAGTGTAGCA
GTTGTGTATTTTAGCATTATAATATTTGATTGAGGCCCTGAGGTGTTAATATCTCAATCTCAGAGTTAGATGTTCATGTCCTTTTTGAAT
TTTTTAAACATTTTTCATAATTTTTTTTTTAAGTTAGGGAGCACATTGAGTGAAGTTCTCTGTGTAGAACAATACCTTCTGCTCTGCTTC
TCCCAGCTTTCACTGAGGGCTGGAAAAGGACAGGCCTGTCCAGCTGTACTGTCCCACTGTGTATGGGGAAGCTCAGGCTCTGGTGGAAGC
AGGGGGCGTGGATGTCAAACAACTGATGTGGAAACAGGGAGGGAGAGATATAATGAGGCTCTCTAGGCATGTTATTTTTGACCACAAGTT
TTGTTCAGTTTGCTTCAGCCAATCCAAACCATATACTAGAGTGTTCTGTAGTCACAATTCTTATTTCAAATGTAATTCAGCACCTTACAT
AATTTTTGAGAGGTTGTCATTCATCACATATTTACTGAGTTTCTATGTGCCAGGCTCTGTGACTGGATACTGGAGCTATCAAAATGAAAA
AAATAGTGTTAAGAACTCACTCGCTGGTGTTAGAGCAGGTAGATGAGTGGCAATCCATTTAAATCCATTTGCCTTGGCTATTATTTGGAA
TGCCTTTTTTTTTTTTTAGTCTATCTACTGTAGGCAGAAGAATTATTTCTTTAGGGGCTAGCTGTTTATTTTGCTGGCCTTTTTTTCTCT
CTTTCTCTTTTTCTTCTTAAGACGGAGTCTCGCTCTGTCCTCCAGGCTGGAGGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCCG
CCTCCCAGCTTCAAGCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTGCAGGTGCATGCCACCACACCCAGCTAATTTTTTAATT
TTTAGTAGAGATGGGATTTTGCCACGTTGTCCAGCCTGGTCTCGAACTCCTGGCCTCAAGTGATCAGCCCTCCTCAGCCTCCCAAAGTGC
TGGCATTACAGGCATGAGCCACTGCGCCCAGCCTGTTGGGTTTTTTTGGAAAAAAAACAAAAACAACAAATCATCATCCTTTCCTTTAAA
ATGTTTTTTTTTTTTTAAGAAACAATTTTCCCACAAACGGTCTGATTTAACTCCATGAAATCCTCTATTTAGACTGCCTTAAAGTGAAAT
AACTGTTGGTGAACCATAACATTTTGCCAGCTGTGTAGTGATTAGTCCAAATATGTCTCAAGAAGTTAGCACCAAGCATTCTCATCCATT
TAAACTTGATGCTAGGGCTATTTTGCAAAACTTAAAAAGATGCGATCTTGTACATATTTCTGTAACCTGAGCTGAAAACCCAAATAACAA
TCATTGACATACTTTAGGGCTATTGTTTCAGGTGGGGGTGTATACATCCCAGGGGCGTGGAGATGATCAATCCATTGAGGAAGTATTAAG
ATGATTATTTGTATTTAATCTCATCCTTTTAAATTTCTATTTTTGTGTGTTTTATAATGTACATAATATATTGTACAATTGTACACTTCT
ATTATTTATAAATAAACATTTATTGGTGCATTAAGTAGAGCTGAAGTTTCCTGCACCAGGCAAGCCTGGAAATTATCAGTATACTGTGTT
TCTGAGATCAGACTCCTATATGGGTTTGGATCAGATTAAACCATTGAAGGAAAAACAAGAATGGTGGTGGCTTTACATTGCAGATAGGAA
GGAGCAGACATTAATATCCATGCCATATCATGTGTGTACGCTGAAAGATACAGAGGAGGAGTGGCAAGAATTACAACAAAGCATACAGCG
AAAAGAGAGAGCTCTATTGGAAACCAAATCAAAAATAACACATCCTGTGTATAGCCTTTACTTTCCTGAGGAAGCTGCAGTAAAGGAAGA
TGAAGAAGAAGTTTCAGATAAGGGCAGTGATTCTGAAGAAGAAGAAACCAATAGAGATTCCCAAAGTGAGAAAGATGATGGTAGTGACAG
AGACTCTGATAGAGAGCAAGATGAAAAACAAAACAAAGATGATGAAGCAAAAAAAAAAGAAACCTTTAAAAAAAAAACCTACACCTGTGC

>33644_33644_4_GNAS-SEC63_GNAS_chr20_57486241_ENST00000371085_SEC63_chr6_108214782_ENST00000369002_length(amino acids)=541AA_BP=
MGVPFLEQLVLTKVHALNDVTAVVEHTADVLSVHSAGEMRVAVVTPISTGSADPQKLISNEVLGPGHAWVLSGLGSSILRSSVASKFWKV
VLNLRFPSKDFLSEQILLVEEQDHRDGAQPSVVPDALEEVQSLLQAVGLVVLPDDHVVAAAGHHEDDGSHIVEALDPLAAFIALATHVKH
VEVDFVHLELGLKDSRSQDTAAKQVLIARHIVSLLDHVDLVQEVLGTVNQLVLVGAFVAGTHSFILPQSLGMLIEFGREVKVRHVHHTQD
VVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLTIAVAPCSLRVLFAALSIKPINMQDPHLLHNGAFTRFSSTQQQQAV
RGPVDLLVLLQLLLDLFVGLTLRLLLVALVLGLTVPEAAHGGGGGGGARPGCGGGGRGRPHAGREGRGSAGRAGRARARLLGKERAGRTA
GRGPRGARTGGKGRVSVGPRGARSSPPLEPRPRGLMAAAGPRRTRAGAAGAAAAAAAAAALIASAGPPPPPRAKSAAAGGGRRGEEEAAA

--------------------------------------------------------------
>33644_33644_5_GNAS-SEC63_GNAS_chr20_57486241_ENST00000371095_SEC63_chr6_108214782_ENST00000369002_length(transcript)=6585nt_BP=1931nt
CTCGCCGCCGCCGCCTCCTCCTCCCCCCGCCTCCCCCCGCCCGCCGCGGCGCTTTTGGCTCGGGGCGGCGGCGGGGGCCCGGCCGAGGCA
ATAAGAGCGGCGGCGGCGGCAGCGGCGGCAGCAGCTCCCGCAGCTCCTGCTCTGGTCCGCCTCGGCCCGGCGGCGGCCATCAGCCCCCTC
GGCCTCGGCTCGAGGGGCGGGGAGCTGCGCGCGCCCCTCGGTCCGACCGACACCCTCCCCTTCCCGCCCGTCCGCGCGCCCCGCGGCCCG
CGGCCCGCAGTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCGCCCGGCGCTGCCCCGGCCCTCCCGGCCC
GCGTGAGGCCGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGA
CCGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGG
CCACGCACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTA
ATGGAGACAGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACC
TGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTCC
CTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTG
ACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCC
TGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCA
AGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAGA
CCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACA
AGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGG
ATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTG
GAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATCA
TTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTG
AAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCC
CCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTC
TCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAGC
ATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAATTGGAAGTTCATGAGGCTAAGCCTGTGCCAGAAAATCACCCACAGTGGG
ATACAGCAATAGAGGGGGATGAAGACCAGGAGGACAGTGAGGGCTTTGAAGATAGCTTTGAGGAAGAAGAGGAGGAAGAAGAAGATGATG
ACTAAGCAGTACTCTGAATGGACCACAGTGTTTGCACATATTTGCAATTTTTTGCTGTTTTGGAAGTGTATCATAAACCAGAAACAGTAC
AGAACTGATGTTGAGGGAGGTGTAGTTTTTTTACTCTTGAAATGGGTGCATAATATAACTAGGCAGTGGCGGTGCCTTGGTACAACCTGA
AAAATGTTAAGGCTTATTGAAACCTTTCAAGTAGGGGATGGTACATTTATTTCATCTGCAAATGATAATAAATCCTTTGTTATTATAACT
GTCCAGAAGTGTGGGCTATGTATTATCTGATCAGTCTATGGTCCCAGTAAAAGTAAAGATGCAGGAAACACAGTCTGTAAATGAGCGACT
TTTCTTTGTTCAGCTTTAGTTTTAGCAAACACCACAAATATGTTTTAAGTAACATCGCTCAAGTTTAAGTAACATCGCTCAAGTTGATAA
TCTCTTGATAAGCTCTGTTGTTGACATTTTGCAGTGATACAACAGCTCCACTCATAGATTTAAACTTTTATTTTTACTTATCTTGGTCAT
AAGTTGGCATTCTCTCACATTCCACATGATATAGAGGGCTACGTTTTGGAATTTTCCTTTTCTTAATTGCCCAGAGTTATCAGACAGATT
ATAAAAATGGCTTTTAATGGCTTAAACCATTTCTAAACCTCTATCTTAGCAGATCAATGCAGGATCTAATTCTTTTGATAAGTTCTAGCT
CTAAAAGTGATAGTGGGACTGTATGTTTTCTGATACTGGTGGCTTATGTTATTAAACCTTTTTTAAAAAAGGTTCACTCTAAAAGCTGAA
CTACATCCTTAGTTTTCAGTCTACTTGACTCTATCAGGAGCTTTTTAAGGAAAGTAAGTATAACATGCAAAGGAAGCTTTTTTTGTATTC
ATTTTGGACTCCTGTCAATAAAAATAGAAGTTTGTTGACTCGTTTTATGTTTCAATGGTGTGTGTCTTTTTACTATCAGGACATAAATAG
GGCAATCCACTTCTTTATTTTTCAACTAAAGATTGAATAGTATTGTACATTACTGCTAAAGTGACTGCTATTTCTGTATACTGTAGAAAA
ACCCAGGAGTGAGAGGGATTTCCCCTCATAGTACAACTGGAAGGATAGTGCTTGTAAAGAGTAGAGATGTGTACATGATGAATCATTGAG
GGAGGGTGGATATTTTTATTCCTAGATATGGAGGAAACATAAGTCTGTAGTATTATAAAACTGATTGTAATAATTCTTTCCTATCAAAAT
CTCCATAGGTCAAAATATTGTTGGAATACTAAAATTTGCAACCTTGTTTACTTTAAAAGGTTGCCACTTTCAGTGCAGAATACTACCGGC
ATCTTGTTACTGCAATAGTTGGAAATAAAATGTGAAAATTAGCAAAACCATGAATGGTTTTTTTGGTTCTAAATTTAAGATGTAATATTT
CCTATAAAAGGGTGAAAGCAGTTTCTTTCTCTATAACCTCAATCACCAGTTTAGTGAGAGCCTTTCTTGGCAGGCAGGAGGCAGTGTCAC
TGAGGATTTTTTTCATTTACTTCATTGTACAAGTAGGAGGGTGGGTTTAATTTTCAAATCAGGTTCTGCTGTGAAGCACCAGTGTCTTGA
GGCAGCTACTGATTACCTAAGTGTGGTGGCAGGGGGTAAGCCAGCTGGTGTCAAGTGAAAGGAGGGATTAGAGAAAACAGGTGTGGCACG
AAGGCAAGGAAACTGAGCAGACAAGACAGAACAATGTGTAGAATGCATATTTCCTAGTTTTCTTGAAAGATTTCAAGAAAAGTTGTTTTT
TTTTTTCTAGTGGCTACTTTGCCTTAAAGAGGCTTTATAAGTTCATTCACACAGCTGGCTTCTCTGGTTTTAAGATTCTGGAGAGGATGA
TAACCTAGTAACACCACAGTGCTTAAAAAAAAAAAAAAAAAAAAAACTACCATCACCAGAAAATTCCACCAGTTTGTTTTCCTTTTCTCT
TTGTGTGATGTGTATGTACTTCCCAACTAAGTAAAATAAAATTTCCTCTAGTGAGTGCTTTAGGTAACCTCTTTCCATATGGCAGTAGTG
AAAGAACTGAGCCTTCAGTTGATAGTTCTTCTCTCTCCAGCAAGTCGCTAAACTCCACATCCCTTCGTTTTTCCTCTGGAATGAGAATAA
CAAACTATCCTAGTTTGCATTTAATCTAATGGAAACTTGAGCAAAGTTTCAATTTTCTTCCTATAAAGAAACTGACATTTTGTCAACAAT
TGATGAGCCTATAGATCATACAGTGTATAGGAAGTGAAATTGAAACAGTTAAATTATGTGATATTTTTCTCTAATTGGTAAAGTACCTAT
TAAAATACAGCTGTTCATGAGGAGACTTACCACAATTCAAAGTGTAGCAGTTGTGTATTTTAGCATTATAATATTTGATTGAGGCCCTGA
GGTGTTAATATCTCAATCTCAGAGTTAGATGTTCATGTCCTTTTTGAATTTTTTAAACATTTTTCATAATTTTTTTTTTAAGTTAGGGAG
CACATTGAGTGAAGTTCTCTGTGTAGAACAATACCTTCTGCTCTGCTTCTCCCAGCTTTCACTGAGGGCTGGAAAAGGACAGGCCTGTCC
AGCTGTACTGTCCCACTGTGTATGGGGAAGCTCAGGCTCTGGTGGAAGCAGGGGGCGTGGATGTCAAACAACTGATGTGGAAACAGGGAG
GGAGAGATATAATGAGGCTCTCTAGGCATGTTATTTTTGACCACAAGTTTTGTTCAGTTTGCTTCAGCCAATCCAAACCATATACTAGAG
TGTTCTGTAGTCACAATTCTTATTTCAAATGTAATTCAGCACCTTACATAATTTTTGAGAGGTTGTCATTCATCACATATTTACTGAGTT
TCTATGTGCCAGGCTCTGTGACTGGATACTGGAGCTATCAAAATGAAAAAAATAGTGTTAAGAACTCACTCGCTGGTGTTAGAGCAGGTA
GATGAGTGGCAATCCATTTAAATCCATTTGCCTTGGCTATTATTTGGAATGCCTTTTTTTTTTTTTAGTCTATCTACTGTAGGCAGAAGA
ATTATTTCTTTAGGGGCTAGCTGTTTATTTTGCTGGCCTTTTTTTCTCTCTTTCTCTTTTTCTTCTTAAGACGGAGTCTCGCTCTGTCCT
CCAGGCTGGAGGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCCGCCTCCCAGCTTCAAGCGATTCTTCTGCCTCAGCCTCCTGAG
TAGCTGGGACTGCAGGTGCATGCCACCACACCCAGCTAATTTTTTAATTTTTAGTAGAGATGGGATTTTGCCACGTTGTCCAGCCTGGTC
TCGAACTCCTGGCCTCAAGTGATCAGCCCTCCTCAGCCTCCCAAAGTGCTGGCATTACAGGCATGAGCCACTGCGCCCAGCCTGTTGGGT
TTTTTTGGAAAAAAAACAAAAACAACAAATCATCATCCTTTCCTTTAAAATGTTTTTTTTTTTTTAAGAAACAATTTTCCCACAAACGGT
CTGATTTAACTCCATGAAATCCTCTATTTAGACTGCCTTAAAGTGAAATAACTGTTGGTGAACCATAACATTTTGCCAGCTGTGTAGTGA
TTAGTCCAAATATGTCTCAAGAAGTTAGCACCAAGCATTCTCATCCATTTAAACTTGATGCTAGGGCTATTTTGCAAAACTTAAAAAGAT
GCGATCTTGTACATATTTCTGTAACCTGAGCTGAAAACCCAAATAACAATCATTGACATACTTTAGGGCTATTGTTTCAGGTGGGGGTGT
ATACATCCCAGGGGCGTGGAGATGATCAATCCATTGAGGAAGTATTAAGATGATTATTTGTATTTAATCTCATCCTTTTAAATTTCTATT
TTTGTGTGTTTTATAATGTACATAATATATTGTACAATTGTACACTTCTATTATTTATAAATAAACATTTATTGGTGCATTAAGTAGAGC
TGAAGTTTCCTGCACCAGGCAAGCCTGGAAATTATCAGTATACTGTGTTTCTGAGATCAGACTCCTATATGGGTTTGGATCAGATTAAAC
CATTGAAGGAAAAACAAGAATGGTGGTGGCTTTACATTGCAGATAGGAAGGAGCAGACATTAATATCCATGCCATATCATGTGTGTACGC
TGAAAGATACAGAGGAGGAGTGGCAAGAATTACAACAAAGCATACAGCGAAAAGAGAGAGCTCTATTGGAAACCAAATCAAAAATAACAC
ATCCTGTGTATAGCCTTTACTTTCCTGAGGAAGCTGCAGTAAAGGAAGATGAAGAAGAAGTTTCAGATAAGGGCAGTGATTCTGAAGAAG
AAGAAACCAATAGAGATTCCCAAAGTGAGAAAGATGATGGTAGTGACAGAGACTCTGATAGAGAGCAAGATGAAAAACAAAACAAAGATG
ATGAAGCAAAAAAAAAAGAAACCTTTAAAAAAAAAACCTACACCTGTGCTATTACCACAGTCAAAGCAACAGAAACAAAAGCAGGCAAAT

>33644_33644_5_GNAS-SEC63_GNAS_chr20_57486241_ENST00000371095_SEC63_chr6_108214782_ENST00000369002_length(amino acids)=527AA_BP=
MGVPFLEQLVLTKVHALNDVTAVVEHTADVLSVHSAGEMRVAVVTPISTGSADPQKLISNEVLGPGHAWVLSGLGSSILRSSVASKFWKV
VLNLRFPSKDFLSEQILLVEEQDHRDGAQPSVVPDALEEVQSLLQAVGLVVLPDDHVVAAAGHHEDDGSHIVEALDPLAAFIALATHVKH
VEVDFVHLELGLKDSRSQDTAAKQVLIARHIVSLLDHVDLVQEVLGTVNQLVLVGAFVAGTHSFILPQSLGMLIEFGREVKVRHVHHTQD
VVHSELVLGVGQLHGGHQVAHGGHNGFNRLFQVVFDVLHFGCLLTVSIKPINMQDPHLLHNGAFTRFSSTQQQQAVRGPVDLLVLLQLLL
DLFVGLTLRLLLVALVLGLTVPEAAHGGGGGGGARPGCGGGGRGRPHAGREGRGSAGRAGRARARLLGKERAGRTAGRGPRGARTGGKGR

--------------------------------------------------------------
>33644_33644_6_GNAS-SEC63_GNAS_chr20_57486241_ENST00000371100_SEC63_chr6_108214782_ENST00000369002_length(transcript)=8683nt_BP=4029nt
AAAGACTCCAAATCAGTCAGGGAGAGGAGTGGAAGGAGCCAAAACGTCCCTGCGAGGCCTGCGCTCACCAGCCCCCTTACCCAAAGTCCC
GGGCCCCTGGCGCCAGGAGCAGGCTCCTGGAGCCGGAGCCAGCTCGGCACTGGAACCGGCGTCCTCTGGTGGCAGAGAGAGAGCGCTACT
GGCGATTTTCGGACCGAATCGGCACGCTCGTCAGATCCAAGCAGGCGGGACTGGCCTGGAGCAAAAAGAAAGAGAGAGGAGGGCGTAAGG
ATAGACCAAGGAAGAGGGGCTGGGGGGCAGCCTGGGGGCATGAAAAGTGGCCAGGAAGGAGCCAAGACTCCACCAGCAACAATTGAGTTG
CTTCAGCCTCAGTCTAGGGTTCCTTCCAGGCCTTGAACCCCCCAACCTCACAAGGGTTGGAAAGTGAGGCCGGTGAACTTTCCAGCTGGT
ACTTTGATTTTAAAATAATAATAATAATTTTTTCACCCTAGTTCGGTTGGGTGCTCCATCTTACGGAGCCCCAAACTTATTTTGAGAGGC
CGCCACCGTGTTATGGGCGTGCGCAACTGCCTCTACGGCAATAATATGTCAGGACAACGCGATATCCCCCCTGAAATCGGGGAACAGCCC
GAGCAACCACCTTTGGAGGCCCCAGGGGCAGCTGCCCCCGGTGCTGGGCCTAGCCCAGCCGAAGAGATGGAGACCGAACCGCCTCACAAC
GAGCCCATCCCCGTCGAGAATGATGGCGAGGCCTGTGGACCCCCAGAGGTCTCCAGACCCAACTTTCAGGTCCTCAACCCGGCATTCAGG
GAAGCTGGAGCCCATGGAAGCTACAGCCCACCTCCTGAGGAAGCAATGCCCTTCGAGGCTGAACAGCCCAGCTTGGGAGGCTTCTGGCCT
ACACTGGAGCAGCCTGGATTCCCCAGTGGGGTCCATGCAGGCCTTGAGGCCTTCGGCCCAGCACTCATGGAGCCCGGAGCCTTCAGTGGT
GCCAGACCAGGCCTGGGAGGATACAGCCCTCCACCAGAAGAAGCTATGCCCTTTGAGTTTGACCAGCCTGCCCAGAGAGGCTGCAGTCAA
CTTCTCTTACAGGTCCCAGACCTTGCTCCAGGAGGCCCAGGTGCTGCAGGGGTCCCCGGAGCTCCTCCCGAGGAGCCCCAAGCCCTCAGG
CCTGCAAAGGCTGGCTCCAGAGGAGGCTACAGCCCTCCCCCTGAGGAGACTATGCCATTTGAGCTTGATGGAGAAGGATTTGGGGACGAC
AGCCCACCCCCGGGGCTTTCCCGAGTTATCGCACAAGTCGACGGCAGCAGCCAGTTCGCGGCAGTCGCGGCCTCGAGTGCGGTCCGCCTC
ACTCCCGCCGCGAACGCGCCTCCCCTCTGGGTCCCAGGCGCCATCGGCAGCCCATCCCAAGAGGCTGTCAGACCTCCTTCTAACTTCACG
GGCAGCAGCCCCTGGATGGAGATCTCCGGACCCCCGTTCGAGATTGGCAGCGCCCCCGCTGGGGTCGACGACACTCCCGTCAACATGGAC
AGCCCCCCAATCGCGCTTGACGGCCCGCCCATCAAGGTCTCCGGAGCCCCAGATAAGAGAGAGCGAGCAGAGAGACCCCCAGTTGAGGAG
GAAGCAGCAGAGATGGAAGGAGCCGCTGATGCCGCGGAGGGAGGAAAAGTACCCTCTCCGGGGTACGGATCCCCTGCCGCCGGGGCAGCC
TCAGCGGATACCGCTGCCAGGGCAGCCCCTGCAGCCCCAGCCGATCCTGACTCCGGGGCAACCCCAGAAGATCCCGACTCCGGGACAGCA
CCAGCCGATCCTGACTCCGGGGCATTCGCAGCCGATCCCGACTCCGGGGCAGCCCCTGCCGCCCCAGCCGATCCCGACTCCGGGGCGGCC
CCTGACGCCCCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCCCCAGCCGATCCAGATGCCGGGGCGGCCCCTGAGGCTCCCGCCGCC
CCTGCGGCTGCTGAGACCCGGGCAGCCCATGTCGCCCCAGCTGCGCCAGACGCAGGGGCTCCCACTGCCCCAGCCGCTTCTGCCACCCGG
GCAGCCCAAGTCCGCCGGGCGGCCTCTGCAGCCCCTGCCTCCGGGGCCAGACGCAAGATCCATCTCAGACCCCCCAGCCCCGAGATCCAG
GCTGCCGATCCGCCTACTCCGCGGCCTACTCGCGCGTCTGCCTGGCGGGGCAAGTCCGAGAGCAGCCGCGGCCGCCGCGTGTACTACGAT
GAAGGGGTGGCCAGCAGCGACGATGACTCCAGCGGAGACGAGTCCGACGATGGGACCTCCGGATGCCTCCGCTGGTTTCAGCATCGGCGA
AATCGCCGCCGCCGAAAGCCCCAGCGCAACTTACTCCGCAACTTTCTCGTGCAAGCCTTCGGGGGCTGCTTCGGTCGATCTGAGAGTCCC
CAGCCCAAAGCCTCGCGCTCTCTCAAGGTCAAGAAGGTACCCCTGGCGGAGAAGCGCAGACAGATGCGCAAAGAAGCCCTGGAGAAGCGG
GCCCAGAAGCGCGCAGAGAAGAAACGCAGTAAGCTCATCGACAAACAACTCCAGGACGAAAAGATGGGCTACATGTGTACGCACCGCCTG
CTGCTTCTAGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGC
GAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATT
GAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGT
GTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTAC
GAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGC
GATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGAC
GTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTAC
AACATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGC
ACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCA
GAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGAT
GAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGC
CGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTA
AAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTC
CCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAA
AAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAAC
AAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAATTGGAAGTTCATGAGGCTAAG
CCTGTGCCAGAAAATCACCCACAGTGGGATACAGCAATAGAGGGGGATGAAGACCAGGAGGACAGTGAGGGCTTTGAAGATAGCTTTGAG
GAAGAAGAGGAGGAAGAAGAAGATGATGACTAAGCAGTACTCTGAATGGACCACAGTGTTTGCACATATTTGCAATTTTTTGCTGTTTTG
GAAGTGTATCATAAACCAGAAACAGTACAGAACTGATGTTGAGGGAGGTGTAGTTTTTTTACTCTTGAAATGGGTGCATAATATAACTAG
GCAGTGGCGGTGCCTTGGTACAACCTGAAAAATGTTAAGGCTTATTGAAACCTTTCAAGTAGGGGATGGTACATTTATTTCATCTGCAAA
TGATAATAAATCCTTTGTTATTATAACTGTCCAGAAGTGTGGGCTATGTATTATCTGATCAGTCTATGGTCCCAGTAAAAGTAAAGATGC
AGGAAACACAGTCTGTAAATGAGCGACTTTTCTTTGTTCAGCTTTAGTTTTAGCAAACACCACAAATATGTTTTAAGTAACATCGCTCAA
GTTTAAGTAACATCGCTCAAGTTGATAATCTCTTGATAAGCTCTGTTGTTGACATTTTGCAGTGATACAACAGCTCCACTCATAGATTTA
AACTTTTATTTTTACTTATCTTGGTCATAAGTTGGCATTCTCTCACATTCCACATGATATAGAGGGCTACGTTTTGGAATTTTCCTTTTC
TTAATTGCCCAGAGTTATCAGACAGATTATAAAAATGGCTTTTAATGGCTTAAACCATTTCTAAACCTCTATCTTAGCAGATCAATGCAG
GATCTAATTCTTTTGATAAGTTCTAGCTCTAAAAGTGATAGTGGGACTGTATGTTTTCTGATACTGGTGGCTTATGTTATTAAACCTTTT
TTAAAAAAGGTTCACTCTAAAAGCTGAACTACATCCTTAGTTTTCAGTCTACTTGACTCTATCAGGAGCTTTTTAAGGAAAGTAAGTATA
ACATGCAAAGGAAGCTTTTTTTGTATTCATTTTGGACTCCTGTCAATAAAAATAGAAGTTTGTTGACTCGTTTTATGTTTCAATGGTGTG
TGTCTTTTTACTATCAGGACATAAATAGGGCAATCCACTTCTTTATTTTTCAACTAAAGATTGAATAGTATTGTACATTACTGCTAAAGT
GACTGCTATTTCTGTATACTGTAGAAAAACCCAGGAGTGAGAGGGATTTCCCCTCATAGTACAACTGGAAGGATAGTGCTTGTAAAGAGT
AGAGATGTGTACATGATGAATCATTGAGGGAGGGTGGATATTTTTATTCCTAGATATGGAGGAAACATAAGTCTGTAGTATTATAAAACT
GATTGTAATAATTCTTTCCTATCAAAATCTCCATAGGTCAAAATATTGTTGGAATACTAAAATTTGCAACCTTGTTTACTTTAAAAGGTT
GCCACTTTCAGTGCAGAATACTACCGGCATCTTGTTACTGCAATAGTTGGAAATAAAATGTGAAAATTAGCAAAACCATGAATGGTTTTT
TTGGTTCTAAATTTAAGATGTAATATTTCCTATAAAAGGGTGAAAGCAGTTTCTTTCTCTATAACCTCAATCACCAGTTTAGTGAGAGCC
TTTCTTGGCAGGCAGGAGGCAGTGTCACTGAGGATTTTTTTCATTTACTTCATTGTACAAGTAGGAGGGTGGGTTTAATTTTCAAATCAG
GTTCTGCTGTGAAGCACCAGTGTCTTGAGGCAGCTACTGATTACCTAAGTGTGGTGGCAGGGGGTAAGCCAGCTGGTGTCAAGTGAAAGG
AGGGATTAGAGAAAACAGGTGTGGCACGAAGGCAAGGAAACTGAGCAGACAAGACAGAACAATGTGTAGAATGCATATTTCCTAGTTTTC
TTGAAAGATTTCAAGAAAAGTTGTTTTTTTTTTTCTAGTGGCTACTTTGCCTTAAAGAGGCTTTATAAGTTCATTCACACAGCTGGCTTC
TCTGGTTTTAAGATTCTGGAGAGGATGATAACCTAGTAACACCACAGTGCTTAAAAAAAAAAAAAAAAAAAAAACTACCATCACCAGAAA
ATTCCACCAGTTTGTTTTCCTTTTCTCTTTGTGTGATGTGTATGTACTTCCCAACTAAGTAAAATAAAATTTCCTCTAGTGAGTGCTTTA
GGTAACCTCTTTCCATATGGCAGTAGTGAAAGAACTGAGCCTTCAGTTGATAGTTCTTCTCTCTCCAGCAAGTCGCTAAACTCCACATCC
CTTCGTTTTTCCTCTGGAATGAGAATAACAAACTATCCTAGTTTGCATTTAATCTAATGGAAACTTGAGCAAAGTTTCAATTTTCTTCCT
ATAAAGAAACTGACATTTTGTCAACAATTGATGAGCCTATAGATCATACAGTGTATAGGAAGTGAAATTGAAACAGTTAAATTATGTGAT
ATTTTTCTCTAATTGGTAAAGTACCTATTAAAATACAGCTGTTCATGAGGAGACTTACCACAATTCAAAGTGTAGCAGTTGTGTATTTTA
GCATTATAATATTTGATTGAGGCCCTGAGGTGTTAATATCTCAATCTCAGAGTTAGATGTTCATGTCCTTTTTGAATTTTTTAAACATTT
TTCATAATTTTTTTTTTAAGTTAGGGAGCACATTGAGTGAAGTTCTCTGTGTAGAACAATACCTTCTGCTCTGCTTCTCCCAGCTTTCAC
TGAGGGCTGGAAAAGGACAGGCCTGTCCAGCTGTACTGTCCCACTGTGTATGGGGAAGCTCAGGCTCTGGTGGAAGCAGGGGGCGTGGAT
GTCAAACAACTGATGTGGAAACAGGGAGGGAGAGATATAATGAGGCTCTCTAGGCATGTTATTTTTGACCACAAGTTTTGTTCAGTTTGC
TTCAGCCAATCCAAACCATATACTAGAGTGTTCTGTAGTCACAATTCTTATTTCAAATGTAATTCAGCACCTTACATAATTTTTGAGAGG
TTGTCATTCATCACATATTTACTGAGTTTCTATGTGCCAGGCTCTGTGACTGGATACTGGAGCTATCAAAATGAAAAAAATAGTGTTAAG
AACTCACTCGCTGGTGTTAGAGCAGGTAGATGAGTGGCAATCCATTTAAATCCATTTGCCTTGGCTATTATTTGGAATGCCTTTTTTTTT
TTTTAGTCTATCTACTGTAGGCAGAAGAATTATTTCTTTAGGGGCTAGCTGTTTATTTTGCTGGCCTTTTTTTCTCTCTTTCTCTTTTTC
TTCTTAAGACGGAGTCTCGCTCTGTCCTCCAGGCTGGAGGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCCGCCTCCCAGCTTCA
AGCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTGCAGGTGCATGCCACCACACCCAGCTAATTTTTTAATTTTTAGTAGAGATG
GGATTTTGCCACGTTGTCCAGCCTGGTCTCGAACTCCTGGCCTCAAGTGATCAGCCCTCCTCAGCCTCCCAAAGTGCTGGCATTACAGGC
ATGAGCCACTGCGCCCAGCCTGTTGGGTTTTTTTGGAAAAAAAACAAAAACAACAAATCATCATCCTTTCCTTTAAAATGTTTTTTTTTT
TTTAAGAAACAATTTTCCCACAAACGGTCTGATTTAACTCCATGAAATCCTCTATTTAGACTGCCTTAAAGTGAAATAACTGTTGGTGAA
CCATAACATTTTGCCAGCTGTGTAGTGATTAGTCCAAATATGTCTCAAGAAGTTAGCACCAAGCATTCTCATCCATTTAAACTTGATGCT
AGGGCTATTTTGCAAAACTTAAAAAGATGCGATCTTGTACATATTTCTGTAACCTGAGCTGAAAACCCAAATAACAATCATTGACATACT
TTAGGGCTATTGTTTCAGGTGGGGGTGTATACATCCCAGGGGCGTGGAGATGATCAATCCATTGAGGAAGTATTAAGATGATTATTTGTA
TTTAATCTCATCCTTTTAAATTTCTATTTTTGTGTGTTTTATAATGTACATAATATATTGTACAATTGTACACTTCTATTATTTATAAAT
AAACATTTATTGGTGCATTAAGTAGAGCTGAAGTTTCCTGCACCAGGCAAGCCTGGAAATTATCAGTATACTGTGTTTCTGAGATCAGAC
TCCTATATGGGTTTGGATCAGATTAAACCATTGAAGGAAAAACAAGAATGGTGGTGGCTTTACATTGCAGATAGGAAGGAGCAGACATTA
ATATCCATGCCATATCATGTGTGTACGCTGAAAGATACAGAGGAGGAGTGGCAAGAATTACAACAAAGCATACAGCGAAAAGAGAGAGCT
CTATTGGAAACCAAATCAAAAATAACACATCCTGTGTATAGCCTTTACTTTCCTGAGGAAGCTGCAGTAAAGGAAGATGAAGAAGAAGTT
TCAGATAAGGGCAGTGATTCTGAAGAAGAAGAAACCAATAGAGATTCCCAAAGTGAGAAAGATGATGGTAGTGACAGAGACTCTGATAGA
GAGCAAGATGAAAAACAAAACAAAGATGATGAAGCAAAAAAAAAAGAAACCTTTAAAAAAAAAACCTACACCTGTGCTATTACCACAGTC

>33644_33644_6_GNAS-SEC63_GNAS_chr20_57486241_ENST00000371100_SEC63_chr6_108214782_ENST00000369002_length(amino acids)=1044AA_BP=
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG
EGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVR
ACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVAS
SSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYF

--------------------------------------------------------------
>33644_33644_7_GNAS-SEC63_GNAS_chr20_57486241_ENST00000371102_SEC63_chr6_108214782_ENST00000369002_length(transcript)=8092nt_BP=3438nt
GTTATGGGCGTGCGCAACTGCCTCTACGGCAATAATATGTCAGGACAACGCGATATCCCCCCTGAAATCGGGGAACAGCCCGAGCAACCA
CCTTTGGAGGCCCCAGGGGCAGCTGCCCCCGGTGCTGGGCCTAGCCCAGCCGAAGAGATGGAGACCGAACCGCCTCACAACGAGCCCATC
CCCGTCGAGAATGATGGCGAGGCCTGTGGACCCCCAGAGGTCTCCAGACCCAACTTTCAGGTCCTCAACCCGGCATTCAGGGAAGCTGGA
GCCCATGGAAGCTACAGCCCACCTCCTGAGGAAGCAATGCCCTTCGAGGCTGAACAGCCCAGCTTGGGAGGCTTCTGGCCTACACTGGAG
CAGCCTGGATTCCCCAGTGGGGTCCATGCAGGCCTTGAGGCCTTCGGCCCAGCACTCATGGAGCCCGGAGCCTTCAGTGGTGCCAGACCA
GGCCTGGGAGGATACAGCCCTCCACCAGAAGAAGCTATGCCCTTTGAGTTTGACCAGCCTGCCCAGAGAGGCTGCAGTCAACTTCTCTTA
CAGGTCCCAGACCTTGCTCCAGGAGGCCCAGGTGCTGCAGGGGTCCCCGGAGCTCCTCCCGAGGAGCCCCAAGCCCTCAGGCCTGCAAAG
GCTGGCTCCAGAGGAGGCTACAGCCCTCCCCCTGAGGAGACTATGCCATTTGAGCTTGATGGAGAAGGATTTGGGGACGACAGCCCACCC
CCGGGGCTTTCCCGAGTTATCGCACAAGTCGACGGCAGCAGCCAGTTCGCGGCAGTCGCGGCCTCGAGTGCGGTCCGCCTCACTCCCGCC
GCGAACGCGCCTCCCCTCTGGGTCCCAGGCGCCATCGGCAGCCCATCCCAAGAGGCTGTCAGACCTCCTTCTAACTTCACGGGCAGCAGC
CCCTGGATGGAGATCTCCGGACCCCCGTTCGAGATTGGCAGCGCCCCCGCTGGGGTCGACGACACTCCCGTCAACATGGACAGCCCCCCA
ATCGCGCTTGACGGCCCGCCCATCAAGGTCTCCGGAGCCCCAGATAAGAGAGAGCGAGCAGAGAGACCCCCAGTTGAGGAGGAAGCAGCA
GAGATGGAAGGAGCCGCTGATGCCGCGGAGGGAGGAAAAGTACCCTCTCCGGGGTACGGATCCCCTGCCGCCGGGGCAGCCTCAGCGGAT
ACCGCTGCCAGGGCAGCCCCTGCAGCCCCAGCCGATCCTGACTCCGGGGCAACCCCAGAAGATCCCGACTCCGGGACAGCACCAGCCGAT
CCTGACTCCGGGGCATTCGCAGCCGATCCCGACTCCGGGGCAGCCCCTGCCGCCCCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCC
CCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCCCCAGCCGATCCAGATGCCGGGGCGGCCCCTGAGGCTCCCGCCGCCCCTGCGGCT
GCTGAGACCCGGGCAGCCCATGTCGCCCCAGCTGCGCCAGACGCAGGGGCTCCCACTGCCCCAGCCGCTTCTGCCACCCGGGCAGCCCAA
GTCCGCCGGGCGGCCTCTGCAGCCCCTGCCTCCGGGGCCAGACGCAAGATCCATCTCAGACCCCCCAGCCCCGAGATCCAGGCTGCCGAT
CCGCCTACTCCGCGGCCTACTCGCGCGTCTGCCTGGCGGGGCAAGTCCGAGAGCAGCCGCGGCCGCCGCGTGTACTACGATGAAGGGGTG
GCCAGCAGCGACGATGACTCCAGCGGAGACGAGTCCGACGATGGGACCTCCGGATGCCTCCGCTGGTTTCAGCATCGGCGAAATCGCCGC
CGCCGAAAGCCCCAGCGCAACTTACTCCGCAACTTTCTCGTGCAAGCCTTCGGGGGCTGCTTCGGTCGATCTGAGAGTCCCCAGCCCAAA
GCCTCGCGCTCTCTCAAGGTCAAGAAGGTACCCCTGGCGGAGAAGCGCAGACAGATGCGCAAAGAAGCCCTGGAGAAGCGGGCCCAGAAG
CGCGCAGAGAAGAAACGCAGTAAGCTCATCGACAAACAACTCCAGGACGAAAAGATGGGCTACATGTGTACGCACCGCCTGCTGCTTCTA
GGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGACAGTGAGAAGGCAACC
AAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCC
AACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCC
AAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGAC
AAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACC
AAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGAT
GTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTG
AACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAA
GTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAG
GACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTAC
CCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAG
TACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTA
ATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAG
ATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAA
AACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAA
TTAAATGTGAGCAAAGAATTGGAAGTTCATGAGGCTAAGCCTGTGCCAGAAAATCACCCACAGTGGGATACAGCAATAGAGGGGGATGAA
GACCAGGAGGACAGTGAGGGCTTTGAAGATAGCTTTGAGGAAGAAGAGGAGGAAGAAGAAGATGATGACTAAGCAGTACTCTGAATGGAC
CACAGTGTTTGCACATATTTGCAATTTTTTGCTGTTTTGGAAGTGTATCATAAACCAGAAACAGTACAGAACTGATGTTGAGGGAGGTGT
AGTTTTTTTACTCTTGAAATGGGTGCATAATATAACTAGGCAGTGGCGGTGCCTTGGTACAACCTGAAAAATGTTAAGGCTTATTGAAAC
CTTTCAAGTAGGGGATGGTACATTTATTTCATCTGCAAATGATAATAAATCCTTTGTTATTATAACTGTCCAGAAGTGTGGGCTATGTAT
TATCTGATCAGTCTATGGTCCCAGTAAAAGTAAAGATGCAGGAAACACAGTCTGTAAATGAGCGACTTTTCTTTGTTCAGCTTTAGTTTT
AGCAAACACCACAAATATGTTTTAAGTAACATCGCTCAAGTTTAAGTAACATCGCTCAAGTTGATAATCTCTTGATAAGCTCTGTTGTTG
ACATTTTGCAGTGATACAACAGCTCCACTCATAGATTTAAACTTTTATTTTTACTTATCTTGGTCATAAGTTGGCATTCTCTCACATTCC
ACATGATATAGAGGGCTACGTTTTGGAATTTTCCTTTTCTTAATTGCCCAGAGTTATCAGACAGATTATAAAAATGGCTTTTAATGGCTT
AAACCATTTCTAAACCTCTATCTTAGCAGATCAATGCAGGATCTAATTCTTTTGATAAGTTCTAGCTCTAAAAGTGATAGTGGGACTGTA
TGTTTTCTGATACTGGTGGCTTATGTTATTAAACCTTTTTTAAAAAAGGTTCACTCTAAAAGCTGAACTACATCCTTAGTTTTCAGTCTA
CTTGACTCTATCAGGAGCTTTTTAAGGAAAGTAAGTATAACATGCAAAGGAAGCTTTTTTTGTATTCATTTTGGACTCCTGTCAATAAAA
ATAGAAGTTTGTTGACTCGTTTTATGTTTCAATGGTGTGTGTCTTTTTACTATCAGGACATAAATAGGGCAATCCACTTCTTTATTTTTC
AACTAAAGATTGAATAGTATTGTACATTACTGCTAAAGTGACTGCTATTTCTGTATACTGTAGAAAAACCCAGGAGTGAGAGGGATTTCC
CCTCATAGTACAACTGGAAGGATAGTGCTTGTAAAGAGTAGAGATGTGTACATGATGAATCATTGAGGGAGGGTGGATATTTTTATTCCT
AGATATGGAGGAAACATAAGTCTGTAGTATTATAAAACTGATTGTAATAATTCTTTCCTATCAAAATCTCCATAGGTCAAAATATTGTTG
GAATACTAAAATTTGCAACCTTGTTTACTTTAAAAGGTTGCCACTTTCAGTGCAGAATACTACCGGCATCTTGTTACTGCAATAGTTGGA
AATAAAATGTGAAAATTAGCAAAACCATGAATGGTTTTTTTGGTTCTAAATTTAAGATGTAATATTTCCTATAAAAGGGTGAAAGCAGTT
TCTTTCTCTATAACCTCAATCACCAGTTTAGTGAGAGCCTTTCTTGGCAGGCAGGAGGCAGTGTCACTGAGGATTTTTTTCATTTACTTC
ATTGTACAAGTAGGAGGGTGGGTTTAATTTTCAAATCAGGTTCTGCTGTGAAGCACCAGTGTCTTGAGGCAGCTACTGATTACCTAAGTG
TGGTGGCAGGGGGTAAGCCAGCTGGTGTCAAGTGAAAGGAGGGATTAGAGAAAACAGGTGTGGCACGAAGGCAAGGAAACTGAGCAGACA
AGACAGAACAATGTGTAGAATGCATATTTCCTAGTTTTCTTGAAAGATTTCAAGAAAAGTTGTTTTTTTTTTTCTAGTGGCTACTTTGCC
TTAAAGAGGCTTTATAAGTTCATTCACACAGCTGGCTTCTCTGGTTTTAAGATTCTGGAGAGGATGATAACCTAGTAACACCACAGTGCT
TAAAAAAAAAAAAAAAAAAAAAACTACCATCACCAGAAAATTCCACCAGTTTGTTTTCCTTTTCTCTTTGTGTGATGTGTATGTACTTCC
CAACTAAGTAAAATAAAATTTCCTCTAGTGAGTGCTTTAGGTAACCTCTTTCCATATGGCAGTAGTGAAAGAACTGAGCCTTCAGTTGAT
AGTTCTTCTCTCTCCAGCAAGTCGCTAAACTCCACATCCCTTCGTTTTTCCTCTGGAATGAGAATAACAAACTATCCTAGTTTGCATTTA
ATCTAATGGAAACTTGAGCAAAGTTTCAATTTTCTTCCTATAAAGAAACTGACATTTTGTCAACAATTGATGAGCCTATAGATCATACAG
TGTATAGGAAGTGAAATTGAAACAGTTAAATTATGTGATATTTTTCTCTAATTGGTAAAGTACCTATTAAAATACAGCTGTTCATGAGGA
GACTTACCACAATTCAAAGTGTAGCAGTTGTGTATTTTAGCATTATAATATTTGATTGAGGCCCTGAGGTGTTAATATCTCAATCTCAGA
GTTAGATGTTCATGTCCTTTTTGAATTTTTTAAACATTTTTCATAATTTTTTTTTTAAGTTAGGGAGCACATTGAGTGAAGTTCTCTGTG
TAGAACAATACCTTCTGCTCTGCTTCTCCCAGCTTTCACTGAGGGCTGGAAAAGGACAGGCCTGTCCAGCTGTACTGTCCCACTGTGTAT
GGGGAAGCTCAGGCTCTGGTGGAAGCAGGGGGCGTGGATGTCAAACAACTGATGTGGAAACAGGGAGGGAGAGATATAATGAGGCTCTCT
AGGCATGTTATTTTTGACCACAAGTTTTGTTCAGTTTGCTTCAGCCAATCCAAACCATATACTAGAGTGTTCTGTAGTCACAATTCTTAT
TTCAAATGTAATTCAGCACCTTACATAATTTTTGAGAGGTTGTCATTCATCACATATTTACTGAGTTTCTATGTGCCAGGCTCTGTGACT
GGATACTGGAGCTATCAAAATGAAAAAAATAGTGTTAAGAACTCACTCGCTGGTGTTAGAGCAGGTAGATGAGTGGCAATCCATTTAAAT
CCATTTGCCTTGGCTATTATTTGGAATGCCTTTTTTTTTTTTTAGTCTATCTACTGTAGGCAGAAGAATTATTTCTTTAGGGGCTAGCTG
TTTATTTTGCTGGCCTTTTTTTCTCTCTTTCTCTTTTTCTTCTTAAGACGGAGTCTCGCTCTGTCCTCCAGGCTGGAGGAGTGCAGTGGC
ACGATCTCAGCTCACTGCAACCTCCGCCTCCCAGCTTCAAGCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTGCAGGTGCATGC
CACCACACCCAGCTAATTTTTTAATTTTTAGTAGAGATGGGATTTTGCCACGTTGTCCAGCCTGGTCTCGAACTCCTGGCCTCAAGTGAT
CAGCCCTCCTCAGCCTCCCAAAGTGCTGGCATTACAGGCATGAGCCACTGCGCCCAGCCTGTTGGGTTTTTTTGGAAAAAAAACAAAAAC
AACAAATCATCATCCTTTCCTTTAAAATGTTTTTTTTTTTTTAAGAAACAATTTTCCCACAAACGGTCTGATTTAACTCCATGAAATCCT
CTATTTAGACTGCCTTAAAGTGAAATAACTGTTGGTGAACCATAACATTTTGCCAGCTGTGTAGTGATTAGTCCAAATATGTCTCAAGAA
GTTAGCACCAAGCATTCTCATCCATTTAAACTTGATGCTAGGGCTATTTTGCAAAACTTAAAAAGATGCGATCTTGTACATATTTCTGTA
ACCTGAGCTGAAAACCCAAATAACAATCATTGACATACTTTAGGGCTATTGTTTCAGGTGGGGGTGTATACATCCCAGGGGCGTGGAGAT
GATCAATCCATTGAGGAAGTATTAAGATGATTATTTGTATTTAATCTCATCCTTTTAAATTTCTATTTTTGTGTGTTTTATAATGTACAT
AATATATTGTACAATTGTACACTTCTATTATTTATAAATAAACATTTATTGGTGCATTAAGTAGAGCTGAAGTTTCCTGCACCAGGCAAG
CCTGGAAATTATCAGTATACTGTGTTTCTGAGATCAGACTCCTATATGGGTTTGGATCAGATTAAACCATTGAAGGAAAAACAAGAATGG
TGGTGGCTTTACATTGCAGATAGGAAGGAGCAGACATTAATATCCATGCCATATCATGTGTGTACGCTGAAAGATACAGAGGAGGAGTGG
CAAGAATTACAACAAAGCATACAGCGAAAAGAGAGAGCTCTATTGGAAACCAAATCAAAAATAACACATCCTGTGTATAGCCTTTACTTT
CCTGAGGAAGCTGCAGTAAAGGAAGATGAAGAAGAAGTTTCAGATAAGGGCAGTGATTCTGAAGAAGAAGAAACCAATAGAGATTCCCAA
AGTGAGAAAGATGATGGTAGTGACAGAGACTCTGATAGAGAGCAAGATGAAAAACAAAACAAAGATGATGAAGCAAAAAAAAAAGAAACC

>33644_33644_7_GNAS-SEC63_GNAS_chr20_57486241_ENST00000371102_SEC63_chr6_108214782_ENST00000369002_length(amino acids)=1023AA_BP=
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGA
HGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAA
NAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAP
ADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKA
SRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGDSEKATK
VQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDK
IDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALN
LFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GNAS-SEC63

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GNAS-SEC63

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GNAS-SEC63

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	GNAS	C3494506	Pseudohypoparathyroidism, Type Ia	17	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	GNAS	C0242292	McCune-Albright Syndrome	7	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	GNAS	C0016065	Polyostotic fibrous dysplasia	5	CTD_human;ORPHANET
Hgene	GNAS	C1864100	PSEUDOHYPOPARATHYROIDISM, TYPE IB	5	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	GNAS	C2931404	Albright's hereditary osteodystrophy	4	CTD_human;GENOMICS_ENGLAND
Hgene	GNAS	C0033806	Pseudohypoparathyroidism	3	CTD_human
Hgene	GNAS	C0334041	Osteoma cutis	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	GNAS	C0014130	Endocrine System Diseases	2	CTD_human
Hgene	GNAS	C0016064	Fibrous Dysplasia, Monostotic	2	ORPHANET
Hgene	GNAS	C0034013	Precocious Puberty	2	CTD_human
Hgene	GNAS	C0221263	Cafe-au-Lait Spots	2	CTD_human
Hgene	GNAS	C0271527	Cryptogenic sexual precocity	2	CTD_human
Hgene	GNAS	C0342543	Central Precocious Puberty	2	CTD_human
Hgene	GNAS	C1504412	Testotoxicosis	2	CTD_human
Hgene	GNAS	C1857451	Acth-Independent Macronodular Adrenal Hyperplasia	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	GNAS	C2932716	Pseudohypoparathyroidism Type 1C	2	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	GNAS	C0001206	Acromegaly	1	CTD_human
Hgene	GNAS	C0001624	Adrenal Gland Neoplasms	1	CTD_human
Hgene	GNAS	C0003129	Anoxemia	1	CTD_human
Hgene	GNAS	C0003130	Anoxia	1	CTD_human
Hgene	GNAS	C0008370	Cholestasis	1	GENOMICS_ENGLAND
Hgene	GNAS	C0009438	Common Bile Duct Calculi	1	CTD_human
Hgene	GNAS	C0011573	Endogenous depression	1	PSYGENET
Hgene	GNAS	C0019087	Hemorrhagic Disorders	1	CTD_human
Hgene	GNAS	C0020538	Hypertensive disease	1	CTD_human
Hgene	GNAS	C0020796	Profound Mental Retardation	1	CTD_human
Hgene	GNAS	C0021655	Insulin Resistance	1	CTD_human
Hgene	GNAS	C0023897	Liver Diseases, Parasitic	1	CTD_human
Hgene	GNAS	C0025363	Mental Retardation, Psychosocial	1	CTD_human
Hgene	GNAS	C0027819	Neuroblastoma	1	CTD_human
Hgene	GNAS	C0028754	Obesity	1	CTD_human
Hgene	GNAS	C0029396	Heterotopic Ossification	1	CTD_human
Hgene	GNAS	C0032460	Polycystic Ovary Syndrome	1	CTD_human
Hgene	GNAS	C0033835	Pseudopseudohypoparathyroidism	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	GNAS	C0035204	Respiration Disorders	1	CTD_human
Hgene	GNAS	C0036341	Schizophrenia	1	PSYGENET
Hgene	GNAS	C0038587	Substance Withdrawal Syndrome	1	CTD_human
Hgene	GNAS	C0039231	Tachycardia	1	CTD_human
Hgene	GNAS	C0080203	Tachyarrhythmia	1	CTD_human
Hgene	GNAS	C0086189	Drug Withdrawal Symptoms	1	CTD_human
Hgene	GNAS	C0087169	Withdrawal Symptoms	1	CTD_human
Hgene	GNAS	C0206698	Cholangiocarcinoma	1	CTD_human
Hgene	GNAS	C0221357	Brachydactyly	1	CTD_human
Hgene	GNAS	C0242184	Hypoxia	1	CTD_human
Hgene	GNAS	C0242216	Biliary calculi	1	CTD_human
Hgene	GNAS	C0345905	Intrahepatic Cholangiocarcinoma	1	CTD_human
Hgene	GNAS	C0346302	Growth Hormone-Secreting Pituitary Adenoma	1	CTD_human
Hgene	GNAS	C0700292	Hypoxemia	1	CTD_human
Hgene	GNAS	C0750887	Adrenal Cancer	1	CTD_human
Hgene	GNAS	C0917816	Mental deficiency	1	CTD_human
Hgene	GNAS	C0920563	Insulin Sensitivity	1	CTD_human
Hgene	GNAS	C1136382	Sclerocystic Ovaries	1	CTD_human
Hgene	GNAS	C2932715	Pseudohypoparathyroidism Type 1B	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	GNAS	C3489630	Somatotrophinoma, Familial	1	CTD_human
Hgene	GNAS	C3697137	Fibrous dysplasia of bone with intramuscular myxoma	1	ORPHANET
Hgene	GNAS	C3714756	Intellectual Disability	1	CTD_human
Hgene	GNAS	C3805278	Extrahepatic Cholangiocarcinoma	1	CTD_human
Tgene		C0158683	Polycystic liver disease	2	CTD_human;ORPHANET
Tgene		C0022680	Polycystic Kidney Diseases	1	CTD_human
Tgene		C1567435	Polycystic Kidney - body part	1	CTD_human
Tgene		C4310769	POLYCYSTIC LIVER DISEASE 2 WITH OR WITHOUT KIDNEY CYSTS	1	GENOMICS_ENGLAND

Fusion Gene Studies in Kim Lab

Fusion gene:GNAS-SEC63 (FusionGDB2 ID:HG2778TG11231)

Fusion Gene Summary for GNAS-SEC63

Fusion Gene ORF analysis for GNAS-SEC63

Fusion Genomic Features for GNAS-SEC63

Fusion Protein Features for GNAS-SEC63

Fusion Gene Sequence for GNAS-SEC63

Fusion Gene PPI Analysis for GNAS-SEC63

Related Drugs for GNAS-SEC63

Related Diseases for GNAS-SEC63

Fusion Gene Studies
in Kim Lab