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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GNB1-NADK (FusionGDB2 ID:HG2782TG65220)

Fusion Gene Summary for GNB1-NADK

check button Fusion gene summary
Fusion gene informationFusion gene name: GNB1-NADK
Fusion gene ID: hg2782tg65220
HgeneTgene
Gene symbol

GNB1

NADK

Gene ID

2782

65220

Gene nameG protein subunit beta 1NAD kinase
SynonymsMRD42dJ283E3.1
Cytomap('GNB1')('NADK')

1p36.33

1p36.33

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1beta subunit, signal-transducing proteins GS/GIguanine nucleotide binding protein (G protein), beta polypeptide 1testicular tissue protein Li 72transducin beta chain 1NAD kinasepoly(P)/ATP NAD kinase
Modification date2020032120200327
UniProtAcc

P62873

O95544

Ensembl transtripts involved in fusion geneENST00000378609, ENST00000472614, 
ENST00000472614, ENST00000378609, 
Fusion gene scores* DoF score30 X 28 X 15=126003 X 4 X 4=48
# samples 454
** MAII scorelog2(45/12600*10)=-4.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNB1 [Title/Abstract] AND NADK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGNB1(1822259)-NADK(1696885), # samples:9
Anticipated loss of major functional domain due to fusion event.NADK-GNB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NADK-GNB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NADK-GNB1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NADK-GNB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NADK-GNB1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NADK-GNB1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A6IW-01AGNB1chr1

1822259

-NADKchr1

1688749

-
ChimerDB4HNSCTCGA-CR-7395-01AGNB1chr1

1822259

-NADKchr1

1688749

-
ChimerDB4HNSCTCGA-CR-7395GNB1chr1

1822259

-NADKchr1

1688749

-
ChimerDB4LUSCTCGA-77-8154-01AGNB1chr1

1822259

-NADKchr1

1696885

-
ChimerDB4LUSCTCGA-77-8154GNB1chr1

1822259

-NADKchr1

1696885

-
ChimerDB4LUSCTCGA-NC-A5HN-01AGNB1chr1

1822259

-NADKchr1

1696885

-
ChimerDB4LUSCTCGA-NC-A5HNGNB1chr1

1822259

-NADKchr1

1696885

-
ChimerDB4OVTCGA-25-2396-01AGNB1chr1

1822259

-NADKchr1

1696885

-
ChimerDB4STADTCGA-CD-5800-01AGNB1chr1

1822259

-NADKchr1

1696885

-
ChimerDB4UCECTCGA-BK-A139-02AGNB1chr1

1822259

-NADKchr1

1696885

-


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Fusion Gene ORF analysis for GNB1-NADK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000378609ENST00000341426GNB1chr1

1822259

-NADKchr1

1688749

-
5UTR-3CDSENST00000378609ENST00000341991GNB1chr1

1822259

-NADKchr1

1688749

-
5UTR-3CDSENST00000378609ENST00000344463GNB1chr1

1822259

-NADKchr1

1688749

-
5UTR-3CDSENST00000378609ENST00000378625GNB1chr1

1822259

-NADKchr1

1688749

-
5UTR-3CDSENST00000472614ENST00000341426GNB1chr1

1822259

-NADKchr1

1688749

-
5UTR-3CDSENST00000472614ENST00000341991GNB1chr1

1822259

-NADKchr1

1688749

-
5UTR-3CDSENST00000472614ENST00000344463GNB1chr1

1822259

-NADKchr1

1688749

-
5UTR-3CDSENST00000472614ENST00000378625GNB1chr1

1822259

-NADKchr1

1688749

-
5UTR-5UTRENST00000378609ENST00000341426GNB1chr1

1822259

-NADKchr1

1696885

-
5UTR-5UTRENST00000378609ENST00000341991GNB1chr1

1822259

-NADKchr1

1696885

-
5UTR-5UTRENST00000378609ENST00000342348GNB1chr1

1822259

-NADKchr1

1688749

-
5UTR-5UTRENST00000378609ENST00000344463GNB1chr1

1822259

-NADKchr1

1696885

-
5UTR-5UTRENST00000378609ENST00000378625GNB1chr1

1822259

-NADKchr1

1696885

-
5UTR-5UTRENST00000378609ENST00000492768GNB1chr1

1822259

-NADKchr1

1688749

-
5UTR-5UTRENST00000378609ENST00000492768GNB1chr1

1822259

-NADKchr1

1696885

-
5UTR-5UTRENST00000472614ENST00000341426GNB1chr1

1822259

-NADKchr1

1696885

-
5UTR-5UTRENST00000472614ENST00000341991GNB1chr1

1822259

-NADKchr1

1696885

-
5UTR-5UTRENST00000472614ENST00000342348GNB1chr1

1822259

-NADKchr1

1688749

-
5UTR-5UTRENST00000472614ENST00000344463GNB1chr1

1822259

-NADKchr1

1696885

-
5UTR-5UTRENST00000472614ENST00000378625GNB1chr1

1822259

-NADKchr1

1696885

-
5UTR-5UTRENST00000472614ENST00000492768GNB1chr1

1822259

-NADKchr1

1688749

-
5UTR-5UTRENST00000472614ENST00000492768GNB1chr1

1822259

-NADKchr1

1696885

-
5UTR-intronENST00000378609ENST00000342348GNB1chr1

1822259

-NADKchr1

1696885

-
5UTR-intronENST00000472614ENST00000342348GNB1chr1

1822259

-NADKchr1

1696885

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GNB1-NADK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for GNB1-NADK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1822259/:1696885)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNB1

P62873

NADK

O95544

FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GNB1-NADK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GNB1-NADK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GNB1-NADK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GNB1-NADK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGNB1C4310774MENTAL RETARDATION, AUTOSOMAL DOMINANT 425CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneGNB1C0003469Anxiety Disorders1CTD_human
HgeneGNB1C0011573Endogenous depression1CTD_human
HgeneGNB1C0011581Depressive disorder1CTD_human
HgeneGNB1C0025193Melancholia1CTD_human
HgeneGNB1C0036572Seizures1GENOMICS_ENGLAND
HgeneGNB1C0041696Unipolar Depression1CTD_human
HgeneGNB1C0086133Depressive Syndrome1CTD_human
HgeneGNB1C0282126Depression, Neurotic1CTD_human
HgeneGNB1C0376280Anxiety States, Neurotic1CTD_human
HgeneGNB1C0424605Developmental delay (disorder)1GENOMICS_ENGLAND
HgeneGNB1C0557874Global developmental delay1GENOMICS_ENGLAND
HgeneGNB1C1279420Anxiety neurosis (finding)1CTD_human
HgeneGNB1C3714756Intellectual Disability1GENOMICS_ENGLAND