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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABL2-KCNH1 (FusionGDB2 ID:HG27TG3756)

Fusion Gene Summary for ABL2-KCNH1

check button Fusion gene summary
Fusion gene informationFusion gene name: ABL2-KCNH1
Fusion gene ID: hg27tg3756
HgeneTgene
Gene symbol

ABL2

KCNH1

Gene ID

27

3756

Gene nameABL proto-oncogene 2, non-receptor tyrosine kinasepotassium voltage-gated channel subfamily H member 1
SynonymsABLL|ARGEAG|EAG1|Kv10.1|TMBTS|ZLS1|h-eag|hEAG|hEAG1
Cytomap('ABL2')('KCNH1')

1q25.2

1q32.2

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase ABL2Abelson tyrosine-protein kinase 2abelson-related gene proteinc-abl oncogene 2, non-receptor tyrosine kinasetyrosine-protein kinase ARGv-abl Abelson murine leukemia viral oncogene homolog 2potassium voltage-gated channel subfamily H member 1EAG channel 1ether-a-go-go 1ether-a-go-go potassium channel 1ether-a-go-go, Drosophila, homolog ofpotassium channel, voltage gated eag related subfamily H, member 1potassium voltage-gated channel,
Modification date2020032720200313
UniProtAcc

P42684

.
Ensembl transtripts involved in fusion geneENST00000367623, ENST00000392043, 
ENST00000502732, ENST00000507173, 
ENST00000511413, ENST00000344730, 
ENST00000408940, ENST00000504405, 
ENST00000512653, 
Fusion gene scores* DoF score8 X 6 X 6=2886 X 5 X 6=180
# samples 86
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABL2 [Title/Abstract] AND KCNH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABL2(179198376)-KCNH1(210857480), # samples:1
Anticipated loss of major functional domain due to fusion event.ABL2-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABL2-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABL2-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABL2-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABL2-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ABL2-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ABL2-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ABL2-KCNH1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABL2

GO:0018108

peptidyl-tyrosine phosphorylation

15886098

HgeneABL2

GO:0051353

positive regulation of oxidoreductase activity

12893824

TgeneKCNH1

GO:0071805

potassium ion transmembrane transport

22732247|27005320|27325704


check buttonFusion gene breakpoints across ABL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KCNH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-2Y-A9HA-01AABL2chr1

179198376

-KCNH1chr1

210857480

-


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Fusion Gene ORF analysis for ABL2-KCNH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000367623ENST00000367007ABL2chr1

179198376

-KCNH1chr1

210857480

-
Frame-shiftENST00000392043ENST00000367007ABL2chr1

179198376

-KCNH1chr1

210857480

-
Frame-shiftENST00000502732ENST00000367007ABL2chr1

179198376

-KCNH1chr1

210857480

-
Frame-shiftENST00000507173ENST00000367007ABL2chr1

179198376

-KCNH1chr1

210857480

-
Frame-shiftENST00000511413ENST00000367007ABL2chr1

179198376

-KCNH1chr1

210857480

-
In-frameENST00000367623ENST00000271751ABL2chr1

179198376

-KCNH1chr1

210857480

-
In-frameENST00000392043ENST00000271751ABL2chr1

179198376

-KCNH1chr1

210857480

-
In-frameENST00000502732ENST00000271751ABL2chr1

179198376

-KCNH1chr1

210857480

-
In-frameENST00000507173ENST00000271751ABL2chr1

179198376

-KCNH1chr1

210857480

-
In-frameENST00000511413ENST00000271751ABL2chr1

179198376

-KCNH1chr1

210857480

-
intron-3CDSENST00000344730ENST00000271751ABL2chr1

179198376

-KCNH1chr1

210857480

-
intron-3CDSENST00000344730ENST00000367007ABL2chr1

179198376

-KCNH1chr1

210857480

-
intron-3CDSENST00000408940ENST00000271751ABL2chr1

179198376

-KCNH1chr1

210857480

-
intron-3CDSENST00000408940ENST00000367007ABL2chr1

179198376

-KCNH1chr1

210857480

-
intron-3CDSENST00000504405ENST00000271751ABL2chr1

179198376

-KCNH1chr1

210857480

-
intron-3CDSENST00000504405ENST00000367007ABL2chr1

179198376

-KCNH1chr1

210857480

-
intron-3CDSENST00000512653ENST00000271751ABL2chr1

179198376

-KCNH1chr1

210857480

-
intron-3CDSENST00000512653ENST00000367007ABL2chr1

179198376

-KCNH1chr1

210857480

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000502732ABL2chr1179198376-ENST00000271751KCNH1chr1210857480-12873611031218371
ENST00000367623ABL2chr1179198376-ENST00000271751KCNH1chr1210857480-10831571541014286
ENST00000507173ABL2chr1179198376-ENST00000271751KCNH1chr1210857480-10831571541014286
ENST00000511413ABL2chr1179198376-ENST00000271751KCNH1chr1210857480-10831571541014286
ENST00000392043ABL2chr1179198376-ENST00000271751KCNH1chr1210857480-13704441861301371

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000502732ENST00000271751ABL2chr1179198376-KCNH1chr1210857480-0.0187127420.9812873
ENST00000367623ENST00000271751ABL2chr1179198376-KCNH1chr1210857480-0.0190217330.98097825
ENST00000507173ENST00000271751ABL2chr1179198376-KCNH1chr1210857480-0.0190217330.98097825
ENST00000511413ENST00000271751ABL2chr1179198376-KCNH1chr1210857480-0.0190217330.98097825
ENST00000392043ENST00000271751ABL2chr1179198376-KCNH1chr1210857480-0.0160923250.9839077

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Fusion Genomic Features for ABL2-KCNH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ABL2-KCNH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:179198376/chr1:210857480)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABL2

P42684

.
FUNCTION: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. {ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911924_964704990.0RegionCAD (involved in subunit assembly)
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911924_964677963.0RegionCAD (involved in subunit assembly)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113561_56401065.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113732_73901065.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113843_105501065.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113984_98801065.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111561_564521162.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111732_739521162.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111843_1055521162.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111984_988521162.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110561_56452543.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110732_73952543.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110843_105552543.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110984_98852543.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111561_56401147.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111732_73901147.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111843_105501147.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111984_98801147.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112561_564521183.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112732_739521183.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112843_1055521183.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112984_988521183.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112561_56401044.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112732_73901044.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112843_105501044.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112984_98801044.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112561_564521059.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112732_739521059.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112843_1055521059.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112984_988521059.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113561_564521080.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113732_739521080.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113843_1055521080.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113984_988521080.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112561_56401168.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112732_73901168.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112843_105501168.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112984_98801168.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113107_16701065.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113173_26301065.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113288_53901065.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111107_167521162.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111173_263521162.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111288_539521162.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110107_16752543.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110173_26352543.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110288_53952543.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111107_16701147.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111173_26301147.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111288_53901147.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112107_167521183.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112173_263521183.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112288_539521183.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112107_16701044.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112173_26301044.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112288_53901044.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112107_167521059.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112173_263521059.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112288_539521059.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113107_167521080.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113173_263521080.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113288_539521080.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112107_16701168.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112173_26301168.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112288_53901168.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113427_45101065.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113658_66001065.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111427_451521162.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111658_660521162.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110427_45152543.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110658_66052543.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111427_45101147.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111658_66001147.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112427_451521183.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112658_660521183.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112427_45101044.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112658_66001044.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112427_451521059.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112658_660521059.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113427_451521080.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113658_660521080.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112427_45101168.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112658_66001168.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113294_30201065.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113362_36801065.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111294_302521162.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111362_368521162.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110294_30252543.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110362_36852543.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111294_30201147.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111362_36801147.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112294_302521183.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112362_368521183.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112294_30201044.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112362_36801044.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112294_302521059.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112362_368521059.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113294_302521080.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113362_368521080.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112294_30201168.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112362_36801168.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-1131020_118201065.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-1132_10601065.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113694_93001065.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-1111020_1182521162.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-1112_106521162.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111694_930521162.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-1101020_118252543.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-1102_10652543.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110694_93052543.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-1111020_118201147.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-1112_10601147.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111694_93001147.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-1121020_1182521183.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-1122_106521183.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112694_930521183.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-1121020_118201044.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-1122_10601044.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112694_93001044.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-1121020_1182521059.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-1122_106521059.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112694_930521059.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-1131020_1182521080.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-1132_106521080.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113694_930521080.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-1121020_118201168.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-1122_10601168.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112694_93001168.0RegionF-actin-binding
TgeneKCNH1chr1:179198376chr1:210857480ENST0000027175191114_94704990.0DomainPAS
TgeneKCNH1chr1:179198376chr1:210857480ENST0000027175191193_145704990.0DomainPAC
TgeneKCNH1chr1:179198376chr1:210857480ENST0000036700791114_94677963.0DomainPAS
TgeneKCNH1chr1:179198376chr1:210857480ENST0000036700791193_145677963.0DomainPAC
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911449_470704990.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911449_470677963.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911463_468704990.0MotifSelectivity filter
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911463_468677963.0MotifSelectivity filter
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911151_162704990.0RegionRequired for phosphatidylinositol bisphosphate binding
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911673_770704990.0RegionCalmodulin-binding
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911151_162677963.0RegionRequired for phosphatidylinositol bisphosphate binding
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911673_770677963.0RegionCalmodulin-binding
TgeneKCNH1chr1:179198376chr1:210857480ENST000002717519111_220704990.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911242_248704990.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911270_290704990.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911310_345704990.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911369_377704990.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911400_448704990.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911471_477704990.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911499_989704990.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST000003670079111_220677963.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911242_248677963.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911270_290677963.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911310_345677963.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911369_377677963.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911400_448677963.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911471_477677963.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911499_989677963.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911221_241704990.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911249_269704990.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911291_309704990.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911346_368704990.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911378_399704990.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911478_498704990.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911221_241677963.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911249_269677963.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911291_309677963.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911346_368677963.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911378_399677963.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911478_498677963.0TransmembraneHelical%3B Name%3DSegment S6


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Fusion Gene Sequence for ABL2-KCNH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>501_501_1_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000367623_KCNH1_chr1_210857480_ENST00000271751_length(transcript)=1083nt_BP=157nt
ATGGGGCAGCAGGTGGGCCGCGTCGGGGAAGCTCCGGGGCTCCAGCAGCCTCAGCCCCGCGGGATCCGGGGCAGCAGTGCAGCCAGGCCC
TCCGGCCGCAGGCGGGACCCGGCGGGGCGCACCACAGAGACCGGCTTCAATATCTTCACCCAGCATGATTGTGTTCCGGAAGATCAGCGA
TGTGAAACGTGAAGAGGAAGAACGCATGAAACGAAAGAATGAGGCCCCCCTGATCTTGCCCCCGGACCACCCTGTCCGGCGCCTCTTCCA
GAGATTCCGACAGCAGAAAGAGGCCAGGCTGGCAGCTGAGAGAGGGGGCCGGGACCTGGATGACCTAGATGTGGAGAAGGGCAATGTCCT
TACAGAGCATGCCTCCGCCAACCACAGCCTCGTGAAGGCCAGCGTGGTCACCGTGCGTGAGAGTCCTGCCACGCCCGTATCCTTCCAGGC
AGCCTCCACCTCCGGGGTGCCAGACCACGCAAAGCTACAGGCGCCAGGGTCCGAGTGCCTGGGCCCCAAGGGGGGCGGGGGCGATTGTGC
CAAGCGCAAAAGCTGGGCCCGCTTCAAAGATGCTTGCGGGAAGAGTGAGGACTGGAACAAGGTGTCCAAGGCTGAGTCGATGGAGACACT
TCCCGAGAGGACAAAAGCGTCAGGCGAGGCCACACTGAAGAAGACAGACTCGTGTGACAGTGGCATCACCAAGAGCGACTTGCGCCTGGA
CAACGTGGGTGAGGCCAGGAGTCCCCAGGATCGGAGTCCCATCCTGGCAGAGGTCAAGCATTCGTTCTACCCCATCCCTGAGCAGACGCT
GCAGGCCACAGTCCTGGAGGTGAGGCACGAGCTGAAGGAGGACATCAAGGCCTTAAACGCCAAAATGACCAATATTGAGAAACAGCTCTC
TGAGATACTCAGGATATTAACTTCCAGAAGATCCTCTCAGTCTCCTCAGGAGTTGTTTGAAATATCGAGGCCACAGTCCCCAGAATCAGA
GAGAGACATTTTTGGAGCCAGCTGAGAGGTCTATTTAAAAAAAAAGTCAGAGACAGATACCTCCAACCCTGCCGTCACCACCACCCCTAC

>501_501_1_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000367623_KCNH1_chr1_210857480_ENST00000271751_length(amino acids)=286AA_BP=1
MIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRES
PATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSG
ITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEI

--------------------------------------------------------------
>501_501_2_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000392043_KCNH1_chr1_210857480_ENST00000271751_length(transcript)=1370nt_BP=444nt
GCTCGGTGGTTTAAAGATGGCGGCGGCGGTGGCGGCGGCGGCGGCGGCGGCGTTGGGGGCGCGGAGCCGCGACAGGAGGAGGGAAAAGCA
GAATCTGTGAGTCGCCTGGAGGCAGCGCGGCGGCTGCCGTGAGGAGGCCGGGTGCGGAGCCGCCGGTGGCCCAGCCACTCAGGGCCAGGG
CCTGGGCTGGGAGGGAGAGACCGGAGCAGCGCCAGGAGCCCGAGGCCGGAGCCGAGGAGGAATGTGACCAGGGGTCGGCGGGGGCGCGGG
AGTACGCGAGAGCAGGGATGGGGCAGCAGGTGGGCCGCGTCGGGGAAGCTCCGGGGCTCCAGCAGCCTCAGCCCCGCGGGATCCGGGGCA
GCAGTGCAGCCAGGCCCTCCGGCCGCAGGCGGGACCCGGCGGGGCGCACCACAGAGACCGGCTTCAATATCTTCACCCAGCATGATTGTG
TTCCGGAAGATCAGCGATGTGAAACGTGAAGAGGAAGAACGCATGAAACGAAAGAATGAGGCCCCCCTGATCTTGCCCCCGGACCACCCT
GTCCGGCGCCTCTTCCAGAGATTCCGACAGCAGAAAGAGGCCAGGCTGGCAGCTGAGAGAGGGGGCCGGGACCTGGATGACCTAGATGTG
GAGAAGGGCAATGTCCTTACAGAGCATGCCTCCGCCAACCACAGCCTCGTGAAGGCCAGCGTGGTCACCGTGCGTGAGAGTCCTGCCACG
CCCGTATCCTTCCAGGCAGCCTCCACCTCCGGGGTGCCAGACCACGCAAAGCTACAGGCGCCAGGGTCCGAGTGCCTGGGCCCCAAGGGG
GGCGGGGGCGATTGTGCCAAGCGCAAAAGCTGGGCCCGCTTCAAAGATGCTTGCGGGAAGAGTGAGGACTGGAACAAGGTGTCCAAGGCT
GAGTCGATGGAGACACTTCCCGAGAGGACAAAAGCGTCAGGCGAGGCCACACTGAAGAAGACAGACTCGTGTGACAGTGGCATCACCAAG
AGCGACTTGCGCCTGGACAACGTGGGTGAGGCCAGGAGTCCCCAGGATCGGAGTCCCATCCTGGCAGAGGTCAAGCATTCGTTCTACCCC
ATCCCTGAGCAGACGCTGCAGGCCACAGTCCTGGAGGTGAGGCACGAGCTGAAGGAGGACATCAAGGCCTTAAACGCCAAAATGACCAAT
ATTGAGAAACAGCTCTCTGAGATACTCAGGATATTAACTTCCAGAAGATCCTCTCAGTCTCCTCAGGAGTTGTTTGAAATATCGAGGCCA
CAGTCCCCAGAATCAGAGAGAGACATTTTTGGAGCCAGCTGAGAGGTCTATTTAAAAAAAAAGTCAGAGACAGATACCTCCAACCCTGCC

>501_501_2_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000392043_KCNH1_chr1_210857480_ENST00000271751_length(amino acids)=371AA_BP=86
MGGRDRSSARSPRPEPRRNVTRGRRGRGSTREQGWGSRWAASGKLRGSSSLSPAGSGAAVQPGPPAAGGTRRGAPQRPASISSPSMIVFR
KISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPV
SFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSD
LRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQS

--------------------------------------------------------------
>501_501_3_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000502732_KCNH1_chr1_210857480_ENST00000271751_length(transcript)=1287nt_BP=361nt
AAAAGCAGAATCTGTGAGTCGCCTGGAGGCAGCGCGGCGGCTGCCGTGAGGAGGCCGGGTGCGGAGCCGCCGGTGGCCCAGCCACTCAGG
GCCAGGGCCTGGGCTGGGAGGGAGAGACCGGAGCAGCGCCAGGAGCCCGAGGCCGGAGCCGAGGAGGAATGTGACCAGGGGTCGGCGGGG
GCGCGGGAGTACGCGAGAGCAGGGATGGGGCAGCAGGTGGGCCGCGTCGGGGAAGCTCCGGGGCTCCAGCAGCCTCAGCCCCGCGGGATC
CGGGGCAGCAGTGCAGCCAGGCCCTCCGGCCGCAGGCGGGACCCGGCGGGGCGCACCACAGAGACCGGCTTCAATATCTTCACCCAGCAT
GATTGTGTTCCGGAAGATCAGCGATGTGAAACGTGAAGAGGAAGAACGCATGAAACGAAAGAATGAGGCCCCCCTGATCTTGCCCCCGGA
CCACCCTGTCCGGCGCCTCTTCCAGAGATTCCGACAGCAGAAAGAGGCCAGGCTGGCAGCTGAGAGAGGGGGCCGGGACCTGGATGACCT
AGATGTGGAGAAGGGCAATGTCCTTACAGAGCATGCCTCCGCCAACCACAGCCTCGTGAAGGCCAGCGTGGTCACCGTGCGTGAGAGTCC
TGCCACGCCCGTATCCTTCCAGGCAGCCTCCACCTCCGGGGTGCCAGACCACGCAAAGCTACAGGCGCCAGGGTCCGAGTGCCTGGGCCC
CAAGGGGGGCGGGGGCGATTGTGCCAAGCGCAAAAGCTGGGCCCGCTTCAAAGATGCTTGCGGGAAGAGTGAGGACTGGAACAAGGTGTC
CAAGGCTGAGTCGATGGAGACACTTCCCGAGAGGACAAAAGCGTCAGGCGAGGCCACACTGAAGAAGACAGACTCGTGTGACAGTGGCAT
CACCAAGAGCGACTTGCGCCTGGACAACGTGGGTGAGGCCAGGAGTCCCCAGGATCGGAGTCCCATCCTGGCAGAGGTCAAGCATTCGTT
CTACCCCATCCCTGAGCAGACGCTGCAGGCCACAGTCCTGGAGGTGAGGCACGAGCTGAAGGAGGACATCAAGGCCTTAAACGCCAAAAT
GACCAATATTGAGAAACAGCTCTCTGAGATACTCAGGATATTAACTTCCAGAAGATCCTCTCAGTCTCCTCAGGAGTTGTTTGAAATATC
GAGGCCACAGTCCCCAGAATCAGAGAGAGACATTTTTGGAGCCAGCTGAGAGGTCTATTTAAAAAAAAAGTCAGAGACAGATACCTCCAA

>501_501_3_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000502732_KCNH1_chr1_210857480_ENST00000271751_length(amino acids)=371AA_BP=86
MGGRDRSSARSPRPEPRRNVTRGRRGRGSTREQGWGSRWAASGKLRGSSSLSPAGSGAAVQPGPPAAGGTRRGAPQRPASISSPSMIVFR
KISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPV
SFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSD
LRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQS

--------------------------------------------------------------
>501_501_4_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000507173_KCNH1_chr1_210857480_ENST00000271751_length(transcript)=1083nt_BP=157nt
ATGGGGCAGCAGGTGGGCCGCGTCGGGGAAGCTCCGGGGCTCCAGCAGCCTCAGCCCCGCGGGATCCGGGGCAGCAGTGCAGCCAGGCCC
TCCGGCCGCAGGCGGGACCCGGCGGGGCGCACCACAGAGACCGGCTTCAATATCTTCACCCAGCATGATTGTGTTCCGGAAGATCAGCGA
TGTGAAACGTGAAGAGGAAGAACGCATGAAACGAAAGAATGAGGCCCCCCTGATCTTGCCCCCGGACCACCCTGTCCGGCGCCTCTTCCA
GAGATTCCGACAGCAGAAAGAGGCCAGGCTGGCAGCTGAGAGAGGGGGCCGGGACCTGGATGACCTAGATGTGGAGAAGGGCAATGTCCT
TACAGAGCATGCCTCCGCCAACCACAGCCTCGTGAAGGCCAGCGTGGTCACCGTGCGTGAGAGTCCTGCCACGCCCGTATCCTTCCAGGC
AGCCTCCACCTCCGGGGTGCCAGACCACGCAAAGCTACAGGCGCCAGGGTCCGAGTGCCTGGGCCCCAAGGGGGGCGGGGGCGATTGTGC
CAAGCGCAAAAGCTGGGCCCGCTTCAAAGATGCTTGCGGGAAGAGTGAGGACTGGAACAAGGTGTCCAAGGCTGAGTCGATGGAGACACT
TCCCGAGAGGACAAAAGCGTCAGGCGAGGCCACACTGAAGAAGACAGACTCGTGTGACAGTGGCATCACCAAGAGCGACTTGCGCCTGGA
CAACGTGGGTGAGGCCAGGAGTCCCCAGGATCGGAGTCCCATCCTGGCAGAGGTCAAGCATTCGTTCTACCCCATCCCTGAGCAGACGCT
GCAGGCCACAGTCCTGGAGGTGAGGCACGAGCTGAAGGAGGACATCAAGGCCTTAAACGCCAAAATGACCAATATTGAGAAACAGCTCTC
TGAGATACTCAGGATATTAACTTCCAGAAGATCCTCTCAGTCTCCTCAGGAGTTGTTTGAAATATCGAGGCCACAGTCCCCAGAATCAGA
GAGAGACATTTTTGGAGCCAGCTGAGAGGTCTATTTAAAAAAAAAGTCAGAGACAGATACCTCCAACCCTGCCGTCACCACCACCCCTAC

>501_501_4_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000507173_KCNH1_chr1_210857480_ENST00000271751_length(amino acids)=286AA_BP=1
MIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRES
PATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSG
ITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEI

--------------------------------------------------------------
>501_501_5_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000511413_KCNH1_chr1_210857480_ENST00000271751_length(transcript)=1083nt_BP=157nt
ATGGGGCAGCAGGTGGGCCGCGTCGGGGAAGCTCCGGGGCTCCAGCAGCCTCAGCCCCGCGGGATCCGGGGCAGCAGTGCAGCCAGGCCC
TCCGGCCGCAGGCGGGACCCGGCGGGGCGCACCACAGAGACCGGCTTCAATATCTTCACCCAGCATGATTGTGTTCCGGAAGATCAGCGA
TGTGAAACGTGAAGAGGAAGAACGCATGAAACGAAAGAATGAGGCCCCCCTGATCTTGCCCCCGGACCACCCTGTCCGGCGCCTCTTCCA
GAGATTCCGACAGCAGAAAGAGGCCAGGCTGGCAGCTGAGAGAGGGGGCCGGGACCTGGATGACCTAGATGTGGAGAAGGGCAATGTCCT
TACAGAGCATGCCTCCGCCAACCACAGCCTCGTGAAGGCCAGCGTGGTCACCGTGCGTGAGAGTCCTGCCACGCCCGTATCCTTCCAGGC
AGCCTCCACCTCCGGGGTGCCAGACCACGCAAAGCTACAGGCGCCAGGGTCCGAGTGCCTGGGCCCCAAGGGGGGCGGGGGCGATTGTGC
CAAGCGCAAAAGCTGGGCCCGCTTCAAAGATGCTTGCGGGAAGAGTGAGGACTGGAACAAGGTGTCCAAGGCTGAGTCGATGGAGACACT
TCCCGAGAGGACAAAAGCGTCAGGCGAGGCCACACTGAAGAAGACAGACTCGTGTGACAGTGGCATCACCAAGAGCGACTTGCGCCTGGA
CAACGTGGGTGAGGCCAGGAGTCCCCAGGATCGGAGTCCCATCCTGGCAGAGGTCAAGCATTCGTTCTACCCCATCCCTGAGCAGACGCT
GCAGGCCACAGTCCTGGAGGTGAGGCACGAGCTGAAGGAGGACATCAAGGCCTTAAACGCCAAAATGACCAATATTGAGAAACAGCTCTC
TGAGATACTCAGGATATTAACTTCCAGAAGATCCTCTCAGTCTCCTCAGGAGTTGTTTGAAATATCGAGGCCACAGTCCCCAGAATCAGA
GAGAGACATTTTTGGAGCCAGCTGAGAGGTCTATTTAAAAAAAAAGTCAGAGACAGATACCTCCAACCCTGCCGTCACCACCACCCCTAC

>501_501_5_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000511413_KCNH1_chr1_210857480_ENST00000271751_length(amino acids)=286AA_BP=1
MIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRES
PATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSG
ITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEI

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Fusion Gene PPI Analysis for ABL2-KCNH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABL2-KCNH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneABL2P42684DB01254DasatinibMultitargetSmall moleculeApproved|Investigational
HgeneABL2P42684DB01254DasatinibMultitargetSmall moleculeApproved|Investigational
HgeneABL2P42684DB01254DasatinibMultitargetSmall moleculeApproved|Investigational
HgeneABL2P42684DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneABL2P42684DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneABL2P42684DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for ABL2-KCNH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0014544Epilepsy2CTD_human
TgeneC0086237Epilepsy, Cryptogenic2CTD_human
TgeneC0236018Aura2CTD_human
TgeneC0751111Awakening Epilepsy2CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0029463Osteosarcoma1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0796013Zimmerman Laband syndrome1CTD_human;ORPHANET
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1535926Neurodevelopmental Disorders1CTD_human
TgeneC2678486Temple-Baraitser Syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC2678488Hypoplasia of terminal phalanges1GENOMICS_ENGLAND
TgeneC4551773ZIMMERMANN-LABAND SYNDROME 11UNIPROT
TgeneC4704874Mammary Carcinoma, Human1CTD_human