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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GPLD1-BANK1 (FusionGDB2 ID:HG2822TG55024)

Fusion Gene Summary for GPLD1-BANK1

check button Fusion gene summary
Fusion gene informationFusion gene name: GPLD1-BANK1
Fusion gene ID: hg2822tg55024
HgeneTgene
Gene symbol

GPLD1

BANK1

Gene ID

2822

55024

Gene nameglycosylphosphatidylinositol specific phospholipase D1B cell scaffold protein with ankyrin repeats 1
SynonymsGPIPLD|GPIPLDM|PIGPLD|PIGPLD1|PLDBANK
Cytomap('GPLD1')('BANK1')

6p22.3

4q24

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol-glycan-specific phospholipase DGPI-PLDGPI-specific phospholipase DPI-G PLDglycoprotein phospholipase DB-cell scaffold protein with ankyrin repeats
Modification date2020031320200313
UniProtAcc.

Q8NDB2

Ensembl transtripts involved in fusion geneENST00000230036, ENST00000474784, 
Fusion gene scores* DoF score4 X 4 X 5=806 X 6 X 4=144
# samples 56
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPLD1 [Title/Abstract] AND BANK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGPLD1(24486303)-BANK1(102776192), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPLD1

GO:0002430

complement receptor mediated signaling pathway

15907827|19135435

HgeneGPLD1

GO:0006507

GPI anchor release

2760042|15907827|19135435

HgeneGPLD1

GO:0008285

negative regulation of cell proliferation

19135435

HgeneGPLD1

GO:0008286

insulin receptor signaling pathway

18328347

HgeneGPLD1

GO:0009749

response to glucose

15907827

HgeneGPLD1

GO:0032869

cellular response to insulin stimulus

15907827

HgeneGPLD1

GO:0035690

cellular response to drug

17761367

HgeneGPLD1

GO:0043065

positive regulation of apoptotic process

19135435

HgeneGPLD1

GO:0051044

positive regulation of membrane protein ectodomain proteolysis

17720976

HgeneGPLD1

GO:0071277

cellular response to calcium ion

2760042

HgeneGPLD1

GO:0071467

cellular response to pH

17761367

HgeneGPLD1

GO:1900076

regulation of cellular response to insulin stimulus

18328347

TgeneBANK1

GO:0042113

B cell activation

11782428



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-7209-01AGPLD1chr6

24486303

-BANK1chr4

102776192

+
ChimerDB4PRADTCGA-HC-7209GPLD1chr6

24486303

-BANK1chr4

102776192

+


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Fusion Gene ORF analysis for GPLD1-BANK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000230036ENST00000510950GPLD1chr6

24486303

-BANK1chr4

102776192

+
5UTR-3CDSENST00000474784ENST00000322953GPLD1chr6

24486303

-BANK1chr4

102776192

+
5UTR-3CDSENST00000474784ENST00000428908GPLD1chr6

24486303

-BANK1chr4

102776192

+
5UTR-3CDSENST00000474784ENST00000444316GPLD1chr6

24486303

-BANK1chr4

102776192

+
5UTR-3CDSENST00000474784ENST00000504592GPLD1chr6

24486303

-BANK1chr4

102776192

+
5UTR-3CDSENST00000474784ENST00000508653GPLD1chr6

24486303

-BANK1chr4

102776192

+
5UTR-intronENST00000474784ENST00000510950GPLD1chr6

24486303

-BANK1chr4

102776192

+
Frame-shiftENST00000230036ENST00000322953GPLD1chr6

24486303

-BANK1chr4

102776192

+
Frame-shiftENST00000230036ENST00000428908GPLD1chr6

24486303

-BANK1chr4

102776192

+
Frame-shiftENST00000230036ENST00000444316GPLD1chr6

24486303

-BANK1chr4

102776192

+
Frame-shiftENST00000230036ENST00000504592GPLD1chr6

24486303

-BANK1chr4

102776192

+
Frame-shiftENST00000230036ENST00000508653GPLD1chr6

24486303

-BANK1chr4

102776192

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GPLD1-BANK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GPLD1chr624486302-BANK1chr4102776191+1.33E-050.99998665
GPLD1chr624486302-BANK1chr4102776191+1.33E-050.99998665
GPLD1chr624486302-BANK1chr4102776191+1.33E-050.99998665
GPLD1chr624486302-BANK1chr4102776191+1.33E-050.99998665


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GPLD1-BANK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:24486303/:102776192)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BANK1

Q8NDB2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. {ECO:0000269|PubMed:11782428}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GPLD1-BANK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GPLD1-BANK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GPLD1-BANK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GPLD1-BANK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0024141Lupus Erythematosus, Systemic6CTD_human;ORPHANET
TgeneC0242380Libman-Sacks Disease1CTD_human