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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FUOM-DOCK1 (FusionGDB2 ID:HG282969TG1793)

Fusion Gene Summary for FUOM-DOCK1

check button Fusion gene summary
Fusion gene informationFusion gene name: FUOM-DOCK1
Fusion gene ID: hg282969tg1793
HgeneTgene
Gene symbol

FUOM

DOCK1

Gene ID

282969

1793

Gene namefucose mutarotasededicator of cytokinesis 1
SynonymsC10orf125|FUCU|FucMDOCK180|ced5
Cytomap('C10orf125','FUOM')('DOCK1','DOCK1')

10q26.3

10q26.2

Type of geneprotein-codingprotein-coding
Descriptionfucose mutarotaseprotein fucU homologdedicator of cytokinesis protein 1180 kDa protein downstream of CRKDOwnstream of CrK
Modification date2020032020200327
UniProtAcc.

Q14185

Ensembl transtripts involved in fusion geneENST00000278025, ENST00000368552, 
ENST00000447176, ENST00000465384, 
ENST00000368551, 
Fusion gene scores* DoF score1 X 1 X 1=116 X 15 X 8=1920
# samples 116
** MAII scorelog2(1/1*10)=3.32192809488736log2(16/1920*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FUOM [Title/Abstract] AND DOCK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC10orf125(135171427)-DOCK1(129055599), # samples:1
FUOM(135171427)-DOCK1(129055599), # samples:1
Anticipated loss of major functional domain due to fusion event.FUOM-DOCK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FUOM-DOCK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FUOM-DOCK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FUOM-DOCK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FUOM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DOCK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-78-8640-01AC10orf125chr10

135171427

-DOCK1chr10

129055599

+
ChimerDB4LUADTCGA-78-8640-01AFUOMchr10

135171427

-DOCK1chr10

129055599

+


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Fusion Gene ORF analysis for FUOM-DOCK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000278025ENST00000484400FUOMchr10

135171427

-DOCK1chr10

129055599

+
5CDS-3UTRENST00000368552ENST00000484400FUOMchr10

135171427

-DOCK1chr10

129055599

+
5CDS-3UTRENST00000447176ENST00000484400FUOMchr10

135171427

-DOCK1chr10

129055599

+
5UTR-3CDSENST00000465384ENST00000280333FUOMchr10

135171427

-DOCK1chr10

129055599

+
5UTR-3UTRENST00000465384ENST00000484400FUOMchr10

135171427

-DOCK1chr10

129055599

+
In-frameENST00000278025ENST00000280333FUOMchr10

135171427

-DOCK1chr10

129055599

+
In-frameENST00000368552ENST00000280333FUOMchr10

135171427

-DOCK1chr10

129055599

+
In-frameENST00000447176ENST00000280333FUOMchr10

135171427

-DOCK1chr10

129055599

+
intron-3CDSENST00000368551ENST00000280333FUOMchr10

135171427

-DOCK1chr10

129055599

+
intron-3UTRENST00000368551ENST00000484400FUOMchr10

135171427

-DOCK1chr10

129055599

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000278025FUOMchr10135171427-ENST00000280333DOCK1chr10129055599+39051031122814900
ENST00000447176FUOMchr10135171427-ENST00000280333DOCK1chr10129055599+387169782780900
ENST00000368552FUOMchr10135171427-ENST00000280333DOCK1chr10129055599+39051031122814900

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000278025ENST00000280333FUOMchr10135171427-DOCK1chr10129055599+0.0007283570.9992717
ENST00000447176ENST00000280333FUOMchr10135171427-DOCK1chr10129055599+0.000725060.9992749
ENST00000368552ENST00000280333FUOMchr10135171427-DOCK1chr10129055599+0.0007283570.9992717

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Fusion Genomic Features for FUOM-DOCK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FUOMchr10135171426-DOCK1chr10129055598+0.0003758640.99962413
FUOMchr10135171426-DOCK1chr10129055598+0.0003758640.99962413

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FUOM-DOCK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:135171427/chr10:129055599)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DOCK1

Q14185

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). {ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:8657152}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDOCK1chr10:135171427chr10:129055599ENST0000028033327521207_16179621866.0DomainDOCKER
TgeneDOCK1chr10:135171427chr10:129055599ENST0000028033327521687_16959621866.0RegionPhosphoinositide-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDOCK1chr10:135171427chr10:129055599ENST000002803332752425_6099621866.0DomainC2 DOCK-type
TgeneDOCK1chr10:135171427chr10:129055599ENST0000028033327529_709621866.0DomainSH3


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Fusion Gene Sequence for FUOM-DOCK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31776_31776_1_FUOM-DOCK1_FUOM_chr10_135171427_ENST00000278025_DOCK1_chr10_129055599_ENST00000280333_length(transcript)=3905nt_BP=103nt
CGCCCCGTCTGCCGGGCCATGGTGGCGCTGAAGGGTGTCCCCGCACTGCTGTCCCCCGAGCTGCTCTACGCGCTGGCGCGGATGGGGCAC
GGGGACGAGATCGGATTTCCTAATGGAAACATTCATCATGTTTAAGAACCTCATTGGAAAGAACGTTTACCCCTTCGACTGGGTGATCAT
GAACATGGTGCAAAATAAAGTCTTCCTGCGAGCAATTAATCAGTATGCAGATATGCTGAACAAAAAATTTCTGGATCAAGCCAACTTTGA
GCTACAGCTGTGGAACAACTACTTTCACCTGGCTGTTGCTTTCCTTACTCAAGAGTCCCTGCAACTGGAGAATTTTTCAAGTGCCAAGAG
AGCCAAAATCCTTAACAAGTACGGAGATATGAGGAGACAGATTGGCTTTGAAATCAGAGACATGTGGTACAACCTTGGTCAACACAAGAT
AAAGTTCATTCCAGAAATGGTGGGCCCAATATTAGAAATGACATTAATTCCCGAGACGGAGCTGCGCAAAGCCACCATCCCCATCTTCTT
TGATATGATGCAGTGTGAATTCCATTCGACCCGAAGCTTCCAAATGTTTGAAAATGAGATCATCACCAAGCTGGATCATGAAGTCGAAGG
AGGCAGAGGAGACGAACAGTACAAAGTGTTATTTGATAAAATCCTTCTGGAACACTGCAGGAAGCACAAATACCTCGCCAAAACAGGAGA
AACTTTTGTAAAACTCGTTGTGCGCTTAATGGAAAGGCTTTTGGATTATAGAACCATCATGCACGACGAGAACAAAGAAAACCGCATGAG
CTGCACCGTCAATGTGCTGAATTTCTACAAAGAAATTGAAAGAGAAGAAATGTATATAAGGTATTTGTACAAGCTCTGTGACCTGCACAA
GGAGTGTGATAACTACACCGAAGCGGCTTACACCTTGCTTCTCCATGCAAAGCTTCTTAAGTGGTCGGAGGATGTGTGTGTGGCCCACCT
CACCCAGCGGGACGGGTACCAGGCCACCACGCAGGGACAGCTGAAGGAGCAGCTCTACCAGGAAATCATCCACTACTTCGACAAAGGCAA
GATGTGGGAGGAGGCCATTGCCTTGGGCAAGGAGCTAGCCGAGCAGTATGAGAACGAAATGTTTGATTATGAGCAACTCAGCGAATTGCT
GAAAAAACAGGCTCAGTTTTATGAAAACATCGTCAAAGTGATCAGGCCCAAGCCTGACTATTTTGCTGTTGGCTACTACGGACAAGGGTT
CCCCACATTCCTGCGGGGAAAAGTTTTCATTTACCGAGGGAAAGAGTATGAGCGCCGGGAAGATTTTGAGGCTCGGCTCTTAACTCAGTT
TCCAAACGCCGAGAAAATGAAGACAACATCTCCACCAGGCGACGATATTAAAAACTCTCCTGGCCAGTATATTCAGTGCTTCACAGTGAA
GCCCAAACTCGATCTGCCTCCTAAGTTTCACAGGCCAGTGTCAGAGCAGATTGTAAGTTTTTACAGGGTGAACGAGGTCCAGCGATTTGA
ATATTCTCGGCCAATCCGGAAGGGAGAGAAAAACCCAGACAATGAATTTGCGAATATGTGGATCGAGAGAACCATATATACAACTGCATA
TAAATTACCTGGAATTTTAAGGTGGTTTGAGGTCAAGTCTGTTTTCATGGTGGAAATCAGCCCCCTGGAGAATGCCATTGAGACCATGCA
GCTGACGAACGACAAGATCAACAGCATGGTGCAGCAGCACCTGGATGACCCCAGCCTGCCCATCAACCCGCTCTCCATGCTCCTGAACGG
CATCGTGGACCCAGCTGTCATGGGGGGCTTCGCAAACTACGAAAAGGCCTTCTTTACAGACCGGTACCTGCAGGAGCACCCTGAGGCCCA
TGAAAAGATCGAGAAGCTCAAGGACCTGATTGCTTGGCAGATTCCTTTTCTGGCCGAAGGGATCAGAATCCATGGAGACAAAGTCACGGA
GGCACTGAGGCCGTTCCACGAGAGGATGGAGGCCTGTTTCAAACAGCTGAAGGAAAAGGTGGAGAAAGAGTACGGCGTCCGAATCATGCC
CTCAAGTCTGGATGATAGAAGAGGCAGCCGCCCCCGGTCCATGGTGCGGTCCTTCACGATGCCTTCCTCATCCCGCCCTCTGTCTGTGGC
CTCTGTCTCTTCCCTCTCATCGGACAGCACCCCTTCCAGACCAGGCTCCGACGGGTTTGCCCTGGAGCCTCTCCTGCCAAAGAAAATGCA
CTCCAGGTCCCAGGACAAGCTGGACAAGGATGACCTGGAGAAGGAGAAGAAGGACAAGAAGAAGGAAAAAAGGAACAGCAAACATCAAGA
GATATTTGAGAAAGAATTTAAACCCACCGACATTTCCCTGCAGCAGTCTGAGGCTGTGATCCTTTCGGAAACGATAAGTCCCCTGCGGCC
CCAGAGACCGAAGAGCCAGGTGATGAACGTCATTGGAAGCGAAAGGCGCTTCTCGGTGTCCCCCTCGTCACCGTCCTCCCAGCAAACACC
CCCTCCAGTTACACCAAGGGCCAAGCTCAGCTTCAGCATGCAGTCGAGCTTGGAGCTGAACGGCATGACGGGGGCGGACGTGGCCGATGT
CCCACCCCCTCTGCCTCTCAAAGGCAGCGTGGCAGATTACGGGAATTTGATGGAAAACCAGGACTTGCTGGGCTCGCCAACACCTCCACC
TCCCCCTCCACACCAGAGGCATCTGCCACCTCCACTGCCCAGCAAAACTCCGCCTCCTCCCCCTCCAAAGACAACTCGCAAGCAGGCATC
GGTGGACTCCGGGATCGTGCAGTGACGTCGCAAGCCTCTCTGGAAAGAGTGTGCTGCCCCTCCCCATCTCCATGCCCTCTCCTTCTGTGT
CCCCTGAGTCTGCTGTTTACCTCATTGGGCCTGTGATGTTAACATTTCGTGCGACTGCTTTTTCTTCAAAGGAGTTCAGTTCTCACCATG
GAGTGAGTGGCCTTTAGCGTCATGGAGCAAGGTGGGTCTGGGAGGTAGATATGGGTCCGGGATGTGCTATCGTAGTTATCAGAGTTGGGG
GCCTCTGAGTGTGTCTGGCTCTGAGAGAGTCTGAGTCTTGCCCAAACATTCTTTCTTTTTGTGCCAAATGACTTGCATTTGCAAAGAGCT
CAATTGCTCTGAGCTCAGCCAAGTAGGAGAGGCTAGGCCATCACTCTTAGGAAGCTGTGTAGTGATGATGTATAAGAATCCTCCTCACTG
TCATGGGATGTTGTATCCAGCCCCTCCTTGTTCCAGCCGGTGGTGTGACTTCGTTGGTTGAGGTGTGTCTCCAACCTACATCAGACCATG
AAGTTCAACCCCTCCAGGGAAGCTCCTGATTTCCCCTGCATAATTGAAAATAGGATATTTCTCAGCTATTGAACAGTTACTAATTTATGG
GGTGGAAACAGCATTAAGAATACTGAATCAAATGGAAAAACAAATGAATACAGGAAGATAAGTGTTCGTTCTTTTCTGAAAAAGAGTATG
TGTACCACAAGAGCTGGTTTTAATTGGGTGAATTGTTTTTGTCCTCATTCTGTACAGAAATTTGTATATATGATGGTTCTTAGAACTTGT
TTTAATTTTTGTGGTCCTTCCGTTTATTATAATAGGCGTCCACCAATGATTATCCATATGTGTTCTTAATTTTTAACTGCTGGAAGTGTT
AAAACACACACACACACACACACACATTTTTTTTTTGAGAACTCCAAAGTCCTGAAAATTTTGGTGGACAATGATTTTTAAAAAACTAAC
TTTGTATAACCTAATATTTGTATTCTCTCATCTATATTTTTTTATTCACTATAATCATGATACTCTTCTAATAGACTTAAAAGTTAATCA

>31776_31776_1_FUOM-DOCK1_FUOM_chr10_135171427_ENST00000278025_DOCK1_chr10_129055599_ENST00000280333_length(amino acids)=900AA_BP=
METFIMFKNLIGKNVYPFDWVIMNMVQNKVFLRAINQYADMLNKKFLDQANFELQLWNNYFHLAVAFLTQESLQLENFSSAKRAKILNKY
GDMRRQIGFEIRDMWYNLGQHKIKFIPEMVGPILEMTLIPETELRKATIPIFFDMMQCEFHSTRSFQMFENEIITKLDHEVEGGRGDEQY
KVLFDKILLEHCRKHKYLAKTGETFVKLVVRLMERLLDYRTIMHDENKENRMSCTVNVLNFYKEIEREEMYIRYLYKLCDLHKECDNYTE
AAYTLLLHAKLLKWSEDVCVAHLTQRDGYQATTQGQLKEQLYQEIIHYFDKGKMWEEAIALGKELAEQYENEMFDYEQLSELLKKQAQFY
ENIVKVIRPKPDYFAVGYYGQGFPTFLRGKVFIYRGKEYERREDFEARLLTQFPNAEKMKTTSPPGDDIKNSPGQYIQCFTVKPKLDLPP
KFHRPVSEQIVSFYRVNEVQRFEYSRPIRKGEKNPDNEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAIETMQLTNDKIN
SMVQQHLDDPSLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQEHPEAHEKIEKLKDLIAWQIPFLAEGIRIHGDKVTEALRPFHE
RMEACFKQLKEKVEKEYGVRIMPSSLDDRRGSRPRSMVRSFTMPSSSRPLSVASVSSLSSDSTPSRPGSDGFALEPLLPKKMHSRSQDKL
DKDDLEKEKKDKKKEKRNSKHQEIFEKEFKPTDISLQQSEAVILSETISPLRPQRPKSQVMNVIGSERRFSVSPSSPSSQQTPPPVTPRA
KLSFSMQSSLELNGMTGADVADVPPPLPLKGSVADYGNLMENQDLLGSPTPPPPPPHQRHLPPPLPSKTPPPPPPKTTRKQASVDSGIVQ

--------------------------------------------------------------
>31776_31776_2_FUOM-DOCK1_FUOM_chr10_135171427_ENST00000368552_DOCK1_chr10_129055599_ENST00000280333_length(transcript)=3905nt_BP=103nt
CGCCCCGTCTGCCGGGCCATGGTGGCGCTGAAGGGTGTCCCCGCACTGCTGTCCCCCGAGCTGCTCTACGCGCTGGCGCGGATGGGGCAC
GGGGACGAGATCGGATTTCCTAATGGAAACATTCATCATGTTTAAGAACCTCATTGGAAAGAACGTTTACCCCTTCGACTGGGTGATCAT
GAACATGGTGCAAAATAAAGTCTTCCTGCGAGCAATTAATCAGTATGCAGATATGCTGAACAAAAAATTTCTGGATCAAGCCAACTTTGA
GCTACAGCTGTGGAACAACTACTTTCACCTGGCTGTTGCTTTCCTTACTCAAGAGTCCCTGCAACTGGAGAATTTTTCAAGTGCCAAGAG
AGCCAAAATCCTTAACAAGTACGGAGATATGAGGAGACAGATTGGCTTTGAAATCAGAGACATGTGGTACAACCTTGGTCAACACAAGAT
AAAGTTCATTCCAGAAATGGTGGGCCCAATATTAGAAATGACATTAATTCCCGAGACGGAGCTGCGCAAAGCCACCATCCCCATCTTCTT
TGATATGATGCAGTGTGAATTCCATTCGACCCGAAGCTTCCAAATGTTTGAAAATGAGATCATCACCAAGCTGGATCATGAAGTCGAAGG
AGGCAGAGGAGACGAACAGTACAAAGTGTTATTTGATAAAATCCTTCTGGAACACTGCAGGAAGCACAAATACCTCGCCAAAACAGGAGA
AACTTTTGTAAAACTCGTTGTGCGCTTAATGGAAAGGCTTTTGGATTATAGAACCATCATGCACGACGAGAACAAAGAAAACCGCATGAG
CTGCACCGTCAATGTGCTGAATTTCTACAAAGAAATTGAAAGAGAAGAAATGTATATAAGGTATTTGTACAAGCTCTGTGACCTGCACAA
GGAGTGTGATAACTACACCGAAGCGGCTTACACCTTGCTTCTCCATGCAAAGCTTCTTAAGTGGTCGGAGGATGTGTGTGTGGCCCACCT
CACCCAGCGGGACGGGTACCAGGCCACCACGCAGGGACAGCTGAAGGAGCAGCTCTACCAGGAAATCATCCACTACTTCGACAAAGGCAA
GATGTGGGAGGAGGCCATTGCCTTGGGCAAGGAGCTAGCCGAGCAGTATGAGAACGAAATGTTTGATTATGAGCAACTCAGCGAATTGCT
GAAAAAACAGGCTCAGTTTTATGAAAACATCGTCAAAGTGATCAGGCCCAAGCCTGACTATTTTGCTGTTGGCTACTACGGACAAGGGTT
CCCCACATTCCTGCGGGGAAAAGTTTTCATTTACCGAGGGAAAGAGTATGAGCGCCGGGAAGATTTTGAGGCTCGGCTCTTAACTCAGTT
TCCAAACGCCGAGAAAATGAAGACAACATCTCCACCAGGCGACGATATTAAAAACTCTCCTGGCCAGTATATTCAGTGCTTCACAGTGAA
GCCCAAACTCGATCTGCCTCCTAAGTTTCACAGGCCAGTGTCAGAGCAGATTGTAAGTTTTTACAGGGTGAACGAGGTCCAGCGATTTGA
ATATTCTCGGCCAATCCGGAAGGGAGAGAAAAACCCAGACAATGAATTTGCGAATATGTGGATCGAGAGAACCATATATACAACTGCATA
TAAATTACCTGGAATTTTAAGGTGGTTTGAGGTCAAGTCTGTTTTCATGGTGGAAATCAGCCCCCTGGAGAATGCCATTGAGACCATGCA
GCTGACGAACGACAAGATCAACAGCATGGTGCAGCAGCACCTGGATGACCCCAGCCTGCCCATCAACCCGCTCTCCATGCTCCTGAACGG
CATCGTGGACCCAGCTGTCATGGGGGGCTTCGCAAACTACGAAAAGGCCTTCTTTACAGACCGGTACCTGCAGGAGCACCCTGAGGCCCA
TGAAAAGATCGAGAAGCTCAAGGACCTGATTGCTTGGCAGATTCCTTTTCTGGCCGAAGGGATCAGAATCCATGGAGACAAAGTCACGGA
GGCACTGAGGCCGTTCCACGAGAGGATGGAGGCCTGTTTCAAACAGCTGAAGGAAAAGGTGGAGAAAGAGTACGGCGTCCGAATCATGCC
CTCAAGTCTGGATGATAGAAGAGGCAGCCGCCCCCGGTCCATGGTGCGGTCCTTCACGATGCCTTCCTCATCCCGCCCTCTGTCTGTGGC
CTCTGTCTCTTCCCTCTCATCGGACAGCACCCCTTCCAGACCAGGCTCCGACGGGTTTGCCCTGGAGCCTCTCCTGCCAAAGAAAATGCA
CTCCAGGTCCCAGGACAAGCTGGACAAGGATGACCTGGAGAAGGAGAAGAAGGACAAGAAGAAGGAAAAAAGGAACAGCAAACATCAAGA
GATATTTGAGAAAGAATTTAAACCCACCGACATTTCCCTGCAGCAGTCTGAGGCTGTGATCCTTTCGGAAACGATAAGTCCCCTGCGGCC
CCAGAGACCGAAGAGCCAGGTGATGAACGTCATTGGAAGCGAAAGGCGCTTCTCGGTGTCCCCCTCGTCACCGTCCTCCCAGCAAACACC
CCCTCCAGTTACACCAAGGGCCAAGCTCAGCTTCAGCATGCAGTCGAGCTTGGAGCTGAACGGCATGACGGGGGCGGACGTGGCCGATGT
CCCACCCCCTCTGCCTCTCAAAGGCAGCGTGGCAGATTACGGGAATTTGATGGAAAACCAGGACTTGCTGGGCTCGCCAACACCTCCACC
TCCCCCTCCACACCAGAGGCATCTGCCACCTCCACTGCCCAGCAAAACTCCGCCTCCTCCCCCTCCAAAGACAACTCGCAAGCAGGCATC
GGTGGACTCCGGGATCGTGCAGTGACGTCGCAAGCCTCTCTGGAAAGAGTGTGCTGCCCCTCCCCATCTCCATGCCCTCTCCTTCTGTGT
CCCCTGAGTCTGCTGTTTACCTCATTGGGCCTGTGATGTTAACATTTCGTGCGACTGCTTTTTCTTCAAAGGAGTTCAGTTCTCACCATG
GAGTGAGTGGCCTTTAGCGTCATGGAGCAAGGTGGGTCTGGGAGGTAGATATGGGTCCGGGATGTGCTATCGTAGTTATCAGAGTTGGGG
GCCTCTGAGTGTGTCTGGCTCTGAGAGAGTCTGAGTCTTGCCCAAACATTCTTTCTTTTTGTGCCAAATGACTTGCATTTGCAAAGAGCT
CAATTGCTCTGAGCTCAGCCAAGTAGGAGAGGCTAGGCCATCACTCTTAGGAAGCTGTGTAGTGATGATGTATAAGAATCCTCCTCACTG
TCATGGGATGTTGTATCCAGCCCCTCCTTGTTCCAGCCGGTGGTGTGACTTCGTTGGTTGAGGTGTGTCTCCAACCTACATCAGACCATG
AAGTTCAACCCCTCCAGGGAAGCTCCTGATTTCCCCTGCATAATTGAAAATAGGATATTTCTCAGCTATTGAACAGTTACTAATTTATGG
GGTGGAAACAGCATTAAGAATACTGAATCAAATGGAAAAACAAATGAATACAGGAAGATAAGTGTTCGTTCTTTTCTGAAAAAGAGTATG
TGTACCACAAGAGCTGGTTTTAATTGGGTGAATTGTTTTTGTCCTCATTCTGTACAGAAATTTGTATATATGATGGTTCTTAGAACTTGT
TTTAATTTTTGTGGTCCTTCCGTTTATTATAATAGGCGTCCACCAATGATTATCCATATGTGTTCTTAATTTTTAACTGCTGGAAGTGTT
AAAACACACACACACACACACACACATTTTTTTTTTGAGAACTCCAAAGTCCTGAAAATTTTGGTGGACAATGATTTTTAAAAAACTAAC
TTTGTATAACCTAATATTTGTATTCTCTCATCTATATTTTTTTATTCACTATAATCATGATACTCTTCTAATAGACTTAAAAGTTAATCA

>31776_31776_2_FUOM-DOCK1_FUOM_chr10_135171427_ENST00000368552_DOCK1_chr10_129055599_ENST00000280333_length(amino acids)=900AA_BP=
METFIMFKNLIGKNVYPFDWVIMNMVQNKVFLRAINQYADMLNKKFLDQANFELQLWNNYFHLAVAFLTQESLQLENFSSAKRAKILNKY
GDMRRQIGFEIRDMWYNLGQHKIKFIPEMVGPILEMTLIPETELRKATIPIFFDMMQCEFHSTRSFQMFENEIITKLDHEVEGGRGDEQY
KVLFDKILLEHCRKHKYLAKTGETFVKLVVRLMERLLDYRTIMHDENKENRMSCTVNVLNFYKEIEREEMYIRYLYKLCDLHKECDNYTE
AAYTLLLHAKLLKWSEDVCVAHLTQRDGYQATTQGQLKEQLYQEIIHYFDKGKMWEEAIALGKELAEQYENEMFDYEQLSELLKKQAQFY
ENIVKVIRPKPDYFAVGYYGQGFPTFLRGKVFIYRGKEYERREDFEARLLTQFPNAEKMKTTSPPGDDIKNSPGQYIQCFTVKPKLDLPP
KFHRPVSEQIVSFYRVNEVQRFEYSRPIRKGEKNPDNEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAIETMQLTNDKIN
SMVQQHLDDPSLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQEHPEAHEKIEKLKDLIAWQIPFLAEGIRIHGDKVTEALRPFHE
RMEACFKQLKEKVEKEYGVRIMPSSLDDRRGSRPRSMVRSFTMPSSSRPLSVASVSSLSSDSTPSRPGSDGFALEPLLPKKMHSRSQDKL
DKDDLEKEKKDKKKEKRNSKHQEIFEKEFKPTDISLQQSEAVILSETISPLRPQRPKSQVMNVIGSERRFSVSPSSPSSQQTPPPVTPRA
KLSFSMQSSLELNGMTGADVADVPPPLPLKGSVADYGNLMENQDLLGSPTPPPPPPHQRHLPPPLPSKTPPPPPPKTTRKQASVDSGIVQ

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>31776_31776_3_FUOM-DOCK1_FUOM_chr10_135171427_ENST00000447176_DOCK1_chr10_129055599_ENST00000280333_length(transcript)=3871nt_BP=69nt
GTGTCCCCGCACTGCTGTCCCCCGAGCTGCTCTACGCGCTGGCGCGGATGGGGCACGGGGACGAGATCGGATTTCCTAATGGAAACATTC
ATCATGTTTAAGAACCTCATTGGAAAGAACGTTTACCCCTTCGACTGGGTGATCATGAACATGGTGCAAAATAAAGTCTTCCTGCGAGCA
ATTAATCAGTATGCAGATATGCTGAACAAAAAATTTCTGGATCAAGCCAACTTTGAGCTACAGCTGTGGAACAACTACTTTCACCTGGCT
GTTGCTTTCCTTACTCAAGAGTCCCTGCAACTGGAGAATTTTTCAAGTGCCAAGAGAGCCAAAATCCTTAACAAGTACGGAGATATGAGG
AGACAGATTGGCTTTGAAATCAGAGACATGTGGTACAACCTTGGTCAACACAAGATAAAGTTCATTCCAGAAATGGTGGGCCCAATATTA
GAAATGACATTAATTCCCGAGACGGAGCTGCGCAAAGCCACCATCCCCATCTTCTTTGATATGATGCAGTGTGAATTCCATTCGACCCGA
AGCTTCCAAATGTTTGAAAATGAGATCATCACCAAGCTGGATCATGAAGTCGAAGGAGGCAGAGGAGACGAACAGTACAAAGTGTTATTT
GATAAAATCCTTCTGGAACACTGCAGGAAGCACAAATACCTCGCCAAAACAGGAGAAACTTTTGTAAAACTCGTTGTGCGCTTAATGGAA
AGGCTTTTGGATTATAGAACCATCATGCACGACGAGAACAAAGAAAACCGCATGAGCTGCACCGTCAATGTGCTGAATTTCTACAAAGAA
ATTGAAAGAGAAGAAATGTATATAAGGTATTTGTACAAGCTCTGTGACCTGCACAAGGAGTGTGATAACTACACCGAAGCGGCTTACACC
TTGCTTCTCCATGCAAAGCTTCTTAAGTGGTCGGAGGATGTGTGTGTGGCCCACCTCACCCAGCGGGACGGGTACCAGGCCACCACGCAG
GGACAGCTGAAGGAGCAGCTCTACCAGGAAATCATCCACTACTTCGACAAAGGCAAGATGTGGGAGGAGGCCATTGCCTTGGGCAAGGAG
CTAGCCGAGCAGTATGAGAACGAAATGTTTGATTATGAGCAACTCAGCGAATTGCTGAAAAAACAGGCTCAGTTTTATGAAAACATCGTC
AAAGTGATCAGGCCCAAGCCTGACTATTTTGCTGTTGGCTACTACGGACAAGGGTTCCCCACATTCCTGCGGGGAAAAGTTTTCATTTAC
CGAGGGAAAGAGTATGAGCGCCGGGAAGATTTTGAGGCTCGGCTCTTAACTCAGTTTCCAAACGCCGAGAAAATGAAGACAACATCTCCA
CCAGGCGACGATATTAAAAACTCTCCTGGCCAGTATATTCAGTGCTTCACAGTGAAGCCCAAACTCGATCTGCCTCCTAAGTTTCACAGG
CCAGTGTCAGAGCAGATTGTAAGTTTTTACAGGGTGAACGAGGTCCAGCGATTTGAATATTCTCGGCCAATCCGGAAGGGAGAGAAAAAC
CCAGACAATGAATTTGCGAATATGTGGATCGAGAGAACCATATATACAACTGCATATAAATTACCTGGAATTTTAAGGTGGTTTGAGGTC
AAGTCTGTTTTCATGGTGGAAATCAGCCCCCTGGAGAATGCCATTGAGACCATGCAGCTGACGAACGACAAGATCAACAGCATGGTGCAG
CAGCACCTGGATGACCCCAGCCTGCCCATCAACCCGCTCTCCATGCTCCTGAACGGCATCGTGGACCCAGCTGTCATGGGGGGCTTCGCA
AACTACGAAAAGGCCTTCTTTACAGACCGGTACCTGCAGGAGCACCCTGAGGCCCATGAAAAGATCGAGAAGCTCAAGGACCTGATTGCT
TGGCAGATTCCTTTTCTGGCCGAAGGGATCAGAATCCATGGAGACAAAGTCACGGAGGCACTGAGGCCGTTCCACGAGAGGATGGAGGCC
TGTTTCAAACAGCTGAAGGAAAAGGTGGAGAAAGAGTACGGCGTCCGAATCATGCCCTCAAGTCTGGATGATAGAAGAGGCAGCCGCCCC
CGGTCCATGGTGCGGTCCTTCACGATGCCTTCCTCATCCCGCCCTCTGTCTGTGGCCTCTGTCTCTTCCCTCTCATCGGACAGCACCCCT
TCCAGACCAGGCTCCGACGGGTTTGCCCTGGAGCCTCTCCTGCCAAAGAAAATGCACTCCAGGTCCCAGGACAAGCTGGACAAGGATGAC
CTGGAGAAGGAGAAGAAGGACAAGAAGAAGGAAAAAAGGAACAGCAAACATCAAGAGATATTTGAGAAAGAATTTAAACCCACCGACATT
TCCCTGCAGCAGTCTGAGGCTGTGATCCTTTCGGAAACGATAAGTCCCCTGCGGCCCCAGAGACCGAAGAGCCAGGTGATGAACGTCATT
GGAAGCGAAAGGCGCTTCTCGGTGTCCCCCTCGTCACCGTCCTCCCAGCAAACACCCCCTCCAGTTACACCAAGGGCCAAGCTCAGCTTC
AGCATGCAGTCGAGCTTGGAGCTGAACGGCATGACGGGGGCGGACGTGGCCGATGTCCCACCCCCTCTGCCTCTCAAAGGCAGCGTGGCA
GATTACGGGAATTTGATGGAAAACCAGGACTTGCTGGGCTCGCCAACACCTCCACCTCCCCCTCCACACCAGAGGCATCTGCCACCTCCA
CTGCCCAGCAAAACTCCGCCTCCTCCCCCTCCAAAGACAACTCGCAAGCAGGCATCGGTGGACTCCGGGATCGTGCAGTGACGTCGCAAG
CCTCTCTGGAAAGAGTGTGCTGCCCCTCCCCATCTCCATGCCCTCTCCTTCTGTGTCCCCTGAGTCTGCTGTTTACCTCATTGGGCCTGT
GATGTTAACATTTCGTGCGACTGCTTTTTCTTCAAAGGAGTTCAGTTCTCACCATGGAGTGAGTGGCCTTTAGCGTCATGGAGCAAGGTG
GGTCTGGGAGGTAGATATGGGTCCGGGATGTGCTATCGTAGTTATCAGAGTTGGGGGCCTCTGAGTGTGTCTGGCTCTGAGAGAGTCTGA
GTCTTGCCCAAACATTCTTTCTTTTTGTGCCAAATGACTTGCATTTGCAAAGAGCTCAATTGCTCTGAGCTCAGCCAAGTAGGAGAGGCT
AGGCCATCACTCTTAGGAAGCTGTGTAGTGATGATGTATAAGAATCCTCCTCACTGTCATGGGATGTTGTATCCAGCCCCTCCTTGTTCC
AGCCGGTGGTGTGACTTCGTTGGTTGAGGTGTGTCTCCAACCTACATCAGACCATGAAGTTCAACCCCTCCAGGGAAGCTCCTGATTTCC
CCTGCATAATTGAAAATAGGATATTTCTCAGCTATTGAACAGTTACTAATTTATGGGGTGGAAACAGCATTAAGAATACTGAATCAAATG
GAAAAACAAATGAATACAGGAAGATAAGTGTTCGTTCTTTTCTGAAAAAGAGTATGTGTACCACAAGAGCTGGTTTTAATTGGGTGAATT
GTTTTTGTCCTCATTCTGTACAGAAATTTGTATATATGATGGTTCTTAGAACTTGTTTTAATTTTTGTGGTCCTTCCGTTTATTATAATA
GGCGTCCACCAATGATTATCCATATGTGTTCTTAATTTTTAACTGCTGGAAGTGTTAAAACACACACACACACACACACACATTTTTTTT
TTGAGAACTCCAAAGTCCTGAAAATTTTGGTGGACAATGATTTTTAAAAAACTAACTTTGTATAACCTAATATTTGTATTCTCTCATCTA
TATTTTTTTATTCACTATAATCATGATACTCTTCTAATAGACTTAAAAGTTAATCATTGACAACGAAAAATAAAATGTTATTTTAAAAGA

>31776_31776_3_FUOM-DOCK1_FUOM_chr10_135171427_ENST00000447176_DOCK1_chr10_129055599_ENST00000280333_length(amino acids)=900AA_BP=
METFIMFKNLIGKNVYPFDWVIMNMVQNKVFLRAINQYADMLNKKFLDQANFELQLWNNYFHLAVAFLTQESLQLENFSSAKRAKILNKY
GDMRRQIGFEIRDMWYNLGQHKIKFIPEMVGPILEMTLIPETELRKATIPIFFDMMQCEFHSTRSFQMFENEIITKLDHEVEGGRGDEQY
KVLFDKILLEHCRKHKYLAKTGETFVKLVVRLMERLLDYRTIMHDENKENRMSCTVNVLNFYKEIEREEMYIRYLYKLCDLHKECDNYTE
AAYTLLLHAKLLKWSEDVCVAHLTQRDGYQATTQGQLKEQLYQEIIHYFDKGKMWEEAIALGKELAEQYENEMFDYEQLSELLKKQAQFY
ENIVKVIRPKPDYFAVGYYGQGFPTFLRGKVFIYRGKEYERREDFEARLLTQFPNAEKMKTTSPPGDDIKNSPGQYIQCFTVKPKLDLPP
KFHRPVSEQIVSFYRVNEVQRFEYSRPIRKGEKNPDNEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAIETMQLTNDKIN
SMVQQHLDDPSLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQEHPEAHEKIEKLKDLIAWQIPFLAEGIRIHGDKVTEALRPFHE
RMEACFKQLKEKVEKEYGVRIMPSSLDDRRGSRPRSMVRSFTMPSSSRPLSVASVSSLSSDSTPSRPGSDGFALEPLLPKKMHSRSQDKL
DKDDLEKEKKDKKKEKRNSKHQEIFEKEFKPTDISLQQSEAVILSETISPLRPQRPKSQVMNVIGSERRFSVSPSSPSSQQTPPPVTPRA
KLSFSMQSSLELNGMTGADVADVPPPLPLKGSVADYGNLMENQDLLGSPTPPPPPPHQRHLPPPLPSKTPPPPPPKTTRKQASVDSGIVQ

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Fusion Gene PPI Analysis for FUOM-DOCK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneDOCK1chr10:135171427chr10:129055599ENST0000028033327521837_1852962.01866.0NCK2 (minor)
TgeneDOCK1chr10:135171427chr10:129055599ENST0000028033327521793_1819962.01866.0NCK2 second and third SH3 domain (minor)
TgeneDOCK1chr10:135171427chr10:129055599ENST0000028033327521820_1836962.01866.0NCK2 third SH3 domain (major)


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FUOM-DOCK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FUOM-DOCK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0013146Drug abuse1CTD_human
TgeneC0013170Drug habituation1CTD_human
TgeneC0013222Drug Use Disorders1CTD_human
TgeneC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneC0038580Substance Dependence1CTD_human
TgeneC0038586Substance Use Disorders1CTD_human
TgeneC0236969Substance-Related Disorders1CTD_human
TgeneC0740858Substance abuse problem1CTD_human
TgeneC1510472Drug Dependence1CTD_human
TgeneC4316881Prescription Drug Abuse1CTD_human