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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CISD3-STARD3 (FusionGDB2 ID:HG284106TG10948)

Fusion Gene Summary for CISD3-STARD3

check button Fusion gene summary
Fusion gene informationFusion gene name: CISD3-STARD3
Fusion gene ID: hg284106tg10948
HgeneTgene
Gene symbol

CISD3

STARD3

Gene ID

284106

10948

Gene nameCDGSH iron sulfur domain 3StAR related lipid transfer domain containing 3
SynonymsMiNT|Miner2CAB1|MLN64|es64
Cytomap('CISD3')('STARD3')

17q12

17q12

Type of geneprotein-codingprotein-coding
DescriptionCDGSH iron-sulfur domain-containing protein 3, mitochondrialmitoNEET related 2mitoNEET-related protein 2mitochondrial inner NEET proteinstAR-related lipid transfer protein 3MLN 64START domain-containing protein 3StAR-related lipid transfer (START) domain containing 3metastatic lymph node gene 64 proteinmetastatic lymph node protein 64steroidogenic acute regulatory protein related
Modification date2020031320200313
UniProtAcc

P0C7P0

.
Ensembl transtripts involved in fusion geneENST00000578573, ENST00000439660, 
Fusion gene scores* DoF score3 X 3 X 3=2715 X 10 X 10=1500
# samples 424
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(24/1500*10)=-2.64385618977472
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CISD3 [Title/Abstract] AND STARD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCISD3(36887048)-STARD3(37813260), # samples:1
CISD3(36887048)-STARD3(37813261), # samples:1
Anticipated loss of major functional domain due to fusion event.CISD3-STARD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CISD3-STARD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CISD3-STARD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CISD3-STARD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCISD3

GO:0106034

protein maturation by [2Fe-2S] cluster transfer

29259115

TgeneSTARD3

GO:0030301

cholesterol transport

28377464

TgeneSTARD3

GO:0099044

vesicle tethering to endoplasmic reticulum

24105263|28377464


check buttonFusion gene breakpoints across CISD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across STARD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-3994-01ACISD3chr17

36887048

+STARD3chr17

37813261

+
ChimerDB4COADTCGA-AA-3994CISD3chr17

36887048

+STARD3chr17

37813260

+


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Fusion Gene ORF analysis for CISD3-STARD3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000578573ENST00000336308CISD3chr17

36887048

+STARD3chr17

37813261

+
3UTR-3CDSENST00000578573ENST00000336308CISD3chr17

36887048

+STARD3chr17

37813260

+
3UTR-3UTRENST00000578573ENST00000394250CISD3chr17

36887048

+STARD3chr17

37813261

+
3UTR-3UTRENST00000578573ENST00000394250CISD3chr17

36887048

+STARD3chr17

37813260

+
3UTR-3UTRENST00000578573ENST00000544210CISD3chr17

36887048

+STARD3chr17

37813261

+
3UTR-3UTRENST00000578573ENST00000544210CISD3chr17

36887048

+STARD3chr17

37813260

+
3UTR-3UTRENST00000578573ENST00000578232CISD3chr17

36887048

+STARD3chr17

37813261

+
3UTR-3UTRENST00000578573ENST00000578232CISD3chr17

36887048

+STARD3chr17

37813260

+
3UTR-intronENST00000578573ENST00000580611CISD3chr17

36887048

+STARD3chr17

37813261

+
3UTR-intronENST00000578573ENST00000580611CISD3chr17

36887048

+STARD3chr17

37813260

+
5CDS-3UTRENST00000439660ENST00000394250CISD3chr17

36887048

+STARD3chr17

37813261

+
5CDS-3UTRENST00000439660ENST00000394250CISD3chr17

36887048

+STARD3chr17

37813260

+
5CDS-3UTRENST00000439660ENST00000544210CISD3chr17

36887048

+STARD3chr17

37813261

+
5CDS-3UTRENST00000439660ENST00000544210CISD3chr17

36887048

+STARD3chr17

37813260

+
5CDS-3UTRENST00000439660ENST00000578232CISD3chr17

36887048

+STARD3chr17

37813261

+
5CDS-3UTRENST00000439660ENST00000578232CISD3chr17

36887048

+STARD3chr17

37813260

+
5CDS-intronENST00000439660ENST00000580611CISD3chr17

36887048

+STARD3chr17

37813261

+
5CDS-intronENST00000439660ENST00000580611CISD3chr17

36887048

+STARD3chr17

37813260

+
In-frameENST00000439660ENST00000336308CISD3chr17

36887048

+STARD3chr17

37813261

+
In-frameENST00000439660ENST00000336308CISD3chr17

36887048

+STARD3chr17

37813260

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000439660CISD3chr1736887048+ENST00000336308STARD3chr1737813260+19032081241326400
ENST00000439660CISD3chr1736887048+ENST00000336308STARD3chr1737813261+19032081241326400

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000439660ENST00000336308CISD3chr1736887048+STARD3chr1737813260+0.0026875650.9973124
ENST00000439660ENST00000336308CISD3chr1736887048+STARD3chr1737813261+0.0026875650.9973124

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Fusion Genomic Features for CISD3-STARD3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CISD3chr1736887048+STARD3chr1737813260+0.0213710610.978629
CISD3chr1736887048+STARD3chr1737813260+0.0213710610.978629
CISD3chr1736887048+STARD3chr1737813260+0.0213710610.978629
CISD3chr1736887048+STARD3chr1737813260+0.0213710610.978629

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CISD3-STARD3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:36887048/chr17:37813260)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CISD3

P0C7P0

.
FUNCTION: Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function. {ECO:0000269|PubMed:29259115}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTARD3chr17:36887048chr17:37813260ENST00000336308115230_44373446.0DomainSTART
TgeneSTARD3chr17:36887048chr17:37813260ENST00000394250114230_44373428.0DomainSTART
TgeneSTARD3chr17:36887048chr17:37813260ENST00000544210115230_44373446.0DomainSTART
TgeneSTARD3chr17:36887048chr17:37813261ENST00000336308115230_44373446.0DomainSTART
TgeneSTARD3chr17:36887048chr17:37813261ENST00000394250114230_44373428.0DomainSTART
TgeneSTARD3chr17:36887048chr17:37813261ENST00000544210115230_44373446.0DomainSTART
TgeneSTARD3chr17:36887048chr17:37813260ENST00000336308115207_21273446.0MotifFFAT
TgeneSTARD3chr17:36887048chr17:37813260ENST00000394250114207_21273428.0MotifFFAT
TgeneSTARD3chr17:36887048chr17:37813260ENST00000544210115207_21273446.0MotifFFAT
TgeneSTARD3chr17:36887048chr17:37813261ENST00000336308115207_21273446.0MotifFFAT
TgeneSTARD3chr17:36887048chr17:37813261ENST00000394250114207_21273428.0MotifFFAT
TgeneSTARD3chr17:36887048chr17:37813261ENST00000544210115207_21273446.0MotifFFAT
TgeneSTARD3chr17:36887048chr17:37813260ENST00000336308115116_12073446.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813260ENST00000336308115142_14873446.0Topological domainExtracellular
TgeneSTARD3chr17:36887048chr17:37813260ENST00000336308115170_44573446.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813260ENST0000033630811573_9473446.0Topological domainExtracellular
TgeneSTARD3chr17:36887048chr17:37813260ENST00000394250114116_12073428.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813260ENST00000394250114142_14873428.0Topological domainExtracellular
TgeneSTARD3chr17:36887048chr17:37813260ENST00000394250114170_44573428.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813260ENST0000039425011473_9473428.0Topological domainExtracellular
TgeneSTARD3chr17:36887048chr17:37813260ENST00000544210115116_12073446.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813260ENST00000544210115142_14873446.0Topological domainExtracellular
TgeneSTARD3chr17:36887048chr17:37813260ENST00000544210115170_44573446.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813260ENST0000054421011573_9473446.0Topological domainExtracellular
TgeneSTARD3chr17:36887048chr17:37813261ENST00000336308115116_12073446.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813261ENST00000336308115142_14873446.0Topological domainExtracellular
TgeneSTARD3chr17:36887048chr17:37813261ENST00000336308115170_44573446.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813261ENST0000033630811573_9473446.0Topological domainExtracellular
TgeneSTARD3chr17:36887048chr17:37813261ENST00000394250114116_12073428.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813261ENST00000394250114142_14873428.0Topological domainExtracellular
TgeneSTARD3chr17:36887048chr17:37813261ENST00000394250114170_44573428.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813261ENST0000039425011473_9473428.0Topological domainExtracellular
TgeneSTARD3chr17:36887048chr17:37813261ENST00000544210115116_12073446.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813261ENST00000544210115142_14873446.0Topological domainExtracellular
TgeneSTARD3chr17:36887048chr17:37813261ENST00000544210115170_44573446.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813261ENST0000054421011573_9473446.0Topological domainExtracellular
TgeneSTARD3chr17:36887048chr17:37813260ENST00000336308115121_14173446.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813260ENST00000336308115149_16973446.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813260ENST0000033630811595_11573446.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813260ENST00000394250114121_14173428.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813260ENST00000394250114149_16973428.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813260ENST0000039425011495_11573428.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813260ENST00000544210115121_14173446.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813260ENST00000544210115149_16973446.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813260ENST0000054421011595_11573446.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813261ENST00000336308115121_14173446.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813261ENST00000336308115149_16973446.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813261ENST0000033630811595_11573446.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813261ENST00000394250114121_14173428.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813261ENST00000394250114149_16973428.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813261ENST0000039425011495_11573428.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813261ENST00000544210115121_14173446.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813261ENST00000544210115149_16973446.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813261ENST0000054421011595_11573446.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTARD3chr17:36887048chr17:37813260ENST0000033630811546_21773446.0DomainMENTAL
TgeneSTARD3chr17:36887048chr17:37813260ENST0000039425011446_21773428.0DomainMENTAL
TgeneSTARD3chr17:36887048chr17:37813260ENST0000054421011546_21773446.0DomainMENTAL
TgeneSTARD3chr17:36887048chr17:37813261ENST0000033630811546_21773446.0DomainMENTAL
TgeneSTARD3chr17:36887048chr17:37813261ENST0000039425011446_21773428.0DomainMENTAL
TgeneSTARD3chr17:36887048chr17:37813261ENST0000054421011546_21773446.0DomainMENTAL
TgeneSTARD3chr17:36887048chr17:37813260ENST000003363081151_5173446.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813260ENST000003942501141_5173428.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813260ENST000005442101151_5173446.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813261ENST000003363081151_5173446.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813261ENST000003942501141_5173428.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813261ENST000005442101151_5173446.0Topological domainCytoplasmic
TgeneSTARD3chr17:36887048chr17:37813260ENST0000033630811552_7273446.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813260ENST0000039425011452_7273428.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813260ENST0000054421011552_7273446.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813261ENST0000033630811552_7273446.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813261ENST0000039425011452_7273428.0TransmembraneHelical
TgeneSTARD3chr17:36887048chr17:37813261ENST0000054421011552_7273446.0TransmembraneHelical


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Fusion Gene Sequence for CISD3-STARD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16851_16851_1_CISD3-STARD3_CISD3_chr17_36887048_ENST00000439660_STARD3_chr17_37813260_ENST00000336308_length(transcript)=1903nt_BP=208nt
CTGGCCTCCGCCCTCGCAGAACGCCGCGGCGTCTTCCGGGGCCTGGCGGGCCGGGGACCGAGGGGGCGGGGAGGTGACCCGGCGGGGGCG
GAGCCAGCGGGCGGGCGCGGCGCGGGAGGCGACCATGCGCGGCGCGGGGGCGATCCTGCGGCCGGCGGCGCGTGGTGCCCGGGACCTGAA
CCCGCGGCGGGACATCTCCTCCTGGCTGACCAACACAGGCATCCGTAAGAACTTGGAGCAGGAGATCATCCAGTACAACTTTAAAACTTC
CTTCTTCGACATCTTTGTCCTGGCCTTCTTCCGCTTCTCTGGACTGCTCCTAGGCTATGCCGTGCTGCGGCTCCGGCACTGGTGGGTGAT
TGCGGTCACGACGCTGGTGTCCAGTGCATTCCTCATTGTCAAGGTCATCCTCTCTGAGCTGCTCAGCAAAGGGGCATTTGGCTACCTGCT
CCCCATCGTCTCTTTTGTCCTCGCCTGGTTGGAGACCTGGTTCCTTGACTTCAAAGTCCTACCCCAGGAAGCTGAAGAGGAGCGATGGTA
TCTTGCCGCCCAGGTTGCTGTTGCCCGTGGACCCCTGCTGTTCTCCGGTGCTCTGTCCGAGGGACAGTTCTATTCACCCCCAGAATCCTT
TGCAGGGTCTGACAATGAATCAGATGAAGAAGTTGCTGGGAAGAAAAGTTTCTCTGCTCAGGAGCGGGAGTACATCCGCCAGGGGAAGGA
GGCCACGGCAGTGGTGGACCAGATCTTGGCCCAGGAAGAGAACTGGAAGTTTGAGAAGAATAATGAATATGGGGACACCGTGTACACCAT
TGAAGTTCCCTTTCACGGCAAGACGTTTATCCTGAAGACCTTCCTGCCCTGTCCTGCGGAGCTCGTGTACCAGGAGGTGATCCTGCAGCC
CGAGAGGATGGTGCTGTGGAACAAGACAGTGACTGCCTGCCAGATCCTGCAGCGAGTGGAAGACAACACCCTCATCTCCTATGACGTGTC
TGCAGGGGCTGCGGGCGGCGTGGTCTCCCCAAGGGACTTCGTGAATGTCCGGCGCATTGAGCGGCGCAGGGACCGATACTTGTCATCAGG
GATCGCCACCTCACACAGTGCCAAGCCCCCGACGCACAAATATGTCCGGGGAGAGAATGGCCCTGGGGGCTTCATCGTGCTCAAGTCGGC
CAGTAACCCCCGTGTTTGCACCTTTGTCTGGATTCTTAATACAGATCTCAAGGGCCGCCTGCCCCGGTACCTCATCCACCAGAGCCTCGC
GGCCACCATGTTTGAATTTGCCTTTCACCTGCGACAGCGCATCAGCGAGCTGGGGGCCCGGGCGTGACTGTGCCCCCTCCCACCCTGCGG
GCCAGGGTCCTGTCGCCACCACTTCCAGAGCCAGAAAGGGTGCCAGTTGGGCTCGCACTGCCCACATGGGACCTGGCCCCAGGCTGTCAC
CCTCCACCGAGCCACGCAGTGCCTGGAGTTGACTGACTGAGCAGGCTGTGGGGTGGAGCACTGGACTCCGGGGCCCCACTGGCTGGAGGA
AGTGGGGTCTGGCCTGTTGATGTTTACATGGCGCCCTGCCTCCTGGAGGACCAGATTGCTCTGCCCCACCTTGCCAGGGCAGGGTCTGGG
CTGGGCACCTGACTTGGCTGGGGAGGACCAGGGCCCTGGGCAGGGCAGGGCAGCCTGTCACCCGTGTGAAGATGAAGGGGCTCTTCATCT
GCCTGCGCTCTCGTCGGTTTTTTTAGGATTATTGAAAGAGTCTGGGACCCTTGTTGGGGAGTGGGTGGCAGGTGGGGGTGGGCTGCTGGC
CATGAATCTCTGCCTCTCCCAGGCTGTCCCCCTCCTCCCAGGGCCTCCTGGGGGACCTTTGTATTAAGCCAATTAAAAACATGAATTTAA

>16851_16851_1_CISD3-STARD3_CISD3_chr17_36887048_ENST00000439660_STARD3_chr17_37813260_ENST00000336308_length(amino acids)=400AA_BP=20
MRGAGAILRPAARGARDLNPRRDISSWLTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFL
IVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEV
AGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVT
ACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWI

--------------------------------------------------------------
>16851_16851_2_CISD3-STARD3_CISD3_chr17_36887048_ENST00000439660_STARD3_chr17_37813261_ENST00000336308_length(transcript)=1903nt_BP=208nt
CTGGCCTCCGCCCTCGCAGAACGCCGCGGCGTCTTCCGGGGCCTGGCGGGCCGGGGACCGAGGGGGCGGGGAGGTGACCCGGCGGGGGCG
GAGCCAGCGGGCGGGCGCGGCGCGGGAGGCGACCATGCGCGGCGCGGGGGCGATCCTGCGGCCGGCGGCGCGTGGTGCCCGGGACCTGAA
CCCGCGGCGGGACATCTCCTCCTGGCTGACCAACACAGGCATCCGTAAGAACTTGGAGCAGGAGATCATCCAGTACAACTTTAAAACTTC
CTTCTTCGACATCTTTGTCCTGGCCTTCTTCCGCTTCTCTGGACTGCTCCTAGGCTATGCCGTGCTGCGGCTCCGGCACTGGTGGGTGAT
TGCGGTCACGACGCTGGTGTCCAGTGCATTCCTCATTGTCAAGGTCATCCTCTCTGAGCTGCTCAGCAAAGGGGCATTTGGCTACCTGCT
CCCCATCGTCTCTTTTGTCCTCGCCTGGTTGGAGACCTGGTTCCTTGACTTCAAAGTCCTACCCCAGGAAGCTGAAGAGGAGCGATGGTA
TCTTGCCGCCCAGGTTGCTGTTGCCCGTGGACCCCTGCTGTTCTCCGGTGCTCTGTCCGAGGGACAGTTCTATTCACCCCCAGAATCCTT
TGCAGGGTCTGACAATGAATCAGATGAAGAAGTTGCTGGGAAGAAAAGTTTCTCTGCTCAGGAGCGGGAGTACATCCGCCAGGGGAAGGA
GGCCACGGCAGTGGTGGACCAGATCTTGGCCCAGGAAGAGAACTGGAAGTTTGAGAAGAATAATGAATATGGGGACACCGTGTACACCAT
TGAAGTTCCCTTTCACGGCAAGACGTTTATCCTGAAGACCTTCCTGCCCTGTCCTGCGGAGCTCGTGTACCAGGAGGTGATCCTGCAGCC
CGAGAGGATGGTGCTGTGGAACAAGACAGTGACTGCCTGCCAGATCCTGCAGCGAGTGGAAGACAACACCCTCATCTCCTATGACGTGTC
TGCAGGGGCTGCGGGCGGCGTGGTCTCCCCAAGGGACTTCGTGAATGTCCGGCGCATTGAGCGGCGCAGGGACCGATACTTGTCATCAGG
GATCGCCACCTCACACAGTGCCAAGCCCCCGACGCACAAATATGTCCGGGGAGAGAATGGCCCTGGGGGCTTCATCGTGCTCAAGTCGGC
CAGTAACCCCCGTGTTTGCACCTTTGTCTGGATTCTTAATACAGATCTCAAGGGCCGCCTGCCCCGGTACCTCATCCACCAGAGCCTCGC
GGCCACCATGTTTGAATTTGCCTTTCACCTGCGACAGCGCATCAGCGAGCTGGGGGCCCGGGCGTGACTGTGCCCCCTCCCACCCTGCGG
GCCAGGGTCCTGTCGCCACCACTTCCAGAGCCAGAAAGGGTGCCAGTTGGGCTCGCACTGCCCACATGGGACCTGGCCCCAGGCTGTCAC
CCTCCACCGAGCCACGCAGTGCCTGGAGTTGACTGACTGAGCAGGCTGTGGGGTGGAGCACTGGACTCCGGGGCCCCACTGGCTGGAGGA
AGTGGGGTCTGGCCTGTTGATGTTTACATGGCGCCCTGCCTCCTGGAGGACCAGATTGCTCTGCCCCACCTTGCCAGGGCAGGGTCTGGG
CTGGGCACCTGACTTGGCTGGGGAGGACCAGGGCCCTGGGCAGGGCAGGGCAGCCTGTCACCCGTGTGAAGATGAAGGGGCTCTTCATCT
GCCTGCGCTCTCGTCGGTTTTTTTAGGATTATTGAAAGAGTCTGGGACCCTTGTTGGGGAGTGGGTGGCAGGTGGGGGTGGGCTGCTGGC
CATGAATCTCTGCCTCTCCCAGGCTGTCCCCCTCCTCCCAGGGCCTCCTGGGGGACCTTTGTATTAAGCCAATTAAAAACATGAATTTAA

>16851_16851_2_CISD3-STARD3_CISD3_chr17_36887048_ENST00000439660_STARD3_chr17_37813261_ENST00000336308_length(amino acids)=400AA_BP=20
MRGAGAILRPAARGARDLNPRRDISSWLTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFL
IVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEV
AGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVT
ACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWI

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Fusion Gene PPI Analysis for CISD3-STARD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CISD3-STARD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CISD3-STARD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0033578Prostatic Neoplasms2CTD_human
TgeneC0376358Malignant neoplasm of prostate2CTD_human
TgeneC3496069cocaine use1PSYGENET