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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF326-CCDC18 (FusionGDB2 ID:HG284695TG343099)

Fusion Gene Summary for ZNF326-CCDC18

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF326-CCDC18
Fusion gene ID: hg284695tg343099
HgeneTgene
Gene symbol

ZNF326

CCDC18

Gene ID

284695

343099

Gene namezinc finger protein 326coiled-coil domain containing 18
SynonymsZAN75|ZIRD|Zfp326|dJ871E2.1NY-SAR-41
Cytomap('ZNF326')('CCDC18')

1p22.2

1p22.1

Type of geneprotein-codingprotein-coding
DescriptionDBIRD complex subunit ZNF326ZNF-protein interacting with nuclear mRNPs and DBC1dJ871E2.1 (novel protein (ortholog of mouse zinc finger protein Zan75))zinc finger protein interacting with mRNPs and DBC1coiled-coil domain-containing protein 18sarcoma antigen NY-SAR-24sarcoma antigen NY-SAR-41
Modification date2020031320200313
UniProtAcc.

Q5T9S5

Ensembl transtripts involved in fusion geneENST00000340281, ENST00000361911, 
ENST00000370447, ENST00000455342, 
Fusion gene scores* DoF score4 X 4 X 3=487 X 12 X 5=420
# samples 511
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/420*10)=-1.93288580414146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF326 [Title/Abstract] AND CCDC18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF326(90460832)-CCDC18(93691890), # samples:3
Anticipated loss of major functional domain due to fusion event.ZNF326-CCDC18 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZNF326-CCDC18 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-2F-A9KR-01AZNF326chr1

90460832

-CCDC18chr1

93691890

+
ChimerDB4BLCATCGA-2F-A9KR-01AZNF326chr1

90460832

+CCDC18chr1

93691890

+
ChimerDB4BLCATCGA-2F-A9KRZNF326chr1

90460832

+CCDC18chr1

93691889

+


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Fusion Gene ORF analysis for ZNF326-CCDC18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000340281ENST00000421014ZNF326chr1

90460832

+CCDC18chr1

93691890

+
5CDS-3UTRENST00000340281ENST00000421014ZNF326chr1

90460832

+CCDC18chr1

93691889

+
5CDS-3UTRENST00000361911ENST00000421014ZNF326chr1

90460832

+CCDC18chr1

93691890

+
5CDS-3UTRENST00000361911ENST00000421014ZNF326chr1

90460832

+CCDC18chr1

93691889

+
5CDS-3UTRENST00000370447ENST00000421014ZNF326chr1

90460832

+CCDC18chr1

93691890

+
5CDS-3UTRENST00000370447ENST00000421014ZNF326chr1

90460832

+CCDC18chr1

93691889

+
5UTR-3CDSENST00000455342ENST00000334652ZNF326chr1

90460832

+CCDC18chr1

93691890

+
5UTR-3CDSENST00000455342ENST00000334652ZNF326chr1

90460832

+CCDC18chr1

93691889

+
5UTR-3CDSENST00000455342ENST00000338949ZNF326chr1

90460832

+CCDC18chr1

93691890

+
5UTR-3CDSENST00000455342ENST00000338949ZNF326chr1

90460832

+CCDC18chr1

93691889

+
5UTR-3CDSENST00000455342ENST00000343253ZNF326chr1

90460832

+CCDC18chr1

93691890

+
5UTR-3CDSENST00000455342ENST00000343253ZNF326chr1

90460832

+CCDC18chr1

93691889

+
5UTR-3CDSENST00000455342ENST00000401026ZNF326chr1

90460832

+CCDC18chr1

93691890

+
5UTR-3CDSENST00000455342ENST00000401026ZNF326chr1

90460832

+CCDC18chr1

93691889

+
5UTR-3CDSENST00000455342ENST00000557479ZNF326chr1

90460832

+CCDC18chr1

93691890

+
5UTR-3CDSENST00000455342ENST00000557479ZNF326chr1

90460832

+CCDC18chr1

93691889

+
5UTR-3UTRENST00000455342ENST00000421014ZNF326chr1

90460832

+CCDC18chr1

93691890

+
5UTR-3UTRENST00000455342ENST00000421014ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000340281ENST00000334652ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000340281ENST00000334652ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000340281ENST00000338949ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000340281ENST00000338949ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000340281ENST00000343253ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000340281ENST00000343253ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000340281ENST00000401026ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000340281ENST00000401026ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000340281ENST00000557479ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000340281ENST00000557479ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000361911ENST00000334652ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000361911ENST00000334652ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000361911ENST00000338949ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000361911ENST00000338949ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000361911ENST00000343253ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000361911ENST00000343253ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000361911ENST00000401026ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000361911ENST00000401026ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000361911ENST00000557479ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000361911ENST00000557479ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000370447ENST00000334652ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000370447ENST00000334652ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000370447ENST00000338949ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000370447ENST00000338949ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000370447ENST00000343253ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000370447ENST00000343253ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000370447ENST00000401026ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000370447ENST00000401026ZNF326chr1

90460832

+CCDC18chr1

93691889

+
Frame-shiftENST00000370447ENST00000557479ZNF326chr1

90460832

+CCDC18chr1

93691890

+
Frame-shiftENST00000370447ENST00000557479ZNF326chr1

90460832

+CCDC18chr1

93691889

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZNF326-CCDC18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF326chr190460832+CCDC18chr193691889+0.0001168710.9998832
ZNF326chr190460832+CCDC18chr193691889+0.0001168710.9998832
ZNF326chr190460832+CCDC18chr193691889+0.0001168710.9998832
ZNF326chr190460832+CCDC18chr193691889+0.0001168710.9998832


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF326-CCDC18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:90460832/:93691890)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCDC18

Q5T9S5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZNF326-CCDC18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZNF326-CCDC18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF326-CCDC18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF326-CCDC18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource