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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM126B-COQ10B (FusionGDB2 ID:HG285172TG80219)

Fusion Gene Summary for FAM126B-COQ10B

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM126B-COQ10B
Fusion gene ID: hg285172tg80219
HgeneTgene
Gene symbol

FAM126B

COQ10B

Gene ID

285172

80219

Gene namefamily with sequence similarity 126 member Bcoenzyme Q10B
SynonymsHYCC2-
Cytomap('FAM126B')('COQ10B')

2q33.1

2q33.1

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM126Bcoenzyme Q-binding protein COQ10 homolog B, mitochondrialcoenzyme Q10 homolog B
Modification date2020031320200313
UniProtAcc

Q8IXS8

Q9H8M1

Ensembl transtripts involved in fusion geneENST00000418596, ENST00000485144, 
Fusion gene scores* DoF score10 X 9 X 7=6303 X 2 X 3=18
# samples 113
** MAII scorelog2(11/630*10)=-2.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM126B [Title/Abstract] AND COQ10B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM126B(201910219)-COQ10B(198324656), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3UF-01AFAM126Bchr2

201910219

-COQ10Bchr2

198324656

+


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Fusion Gene ORF analysis for FAM126B-COQ10B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000418596ENST00000263960FAM126Bchr2

201910219

-COQ10Bchr2

198324656

+
5UTR-3UTRENST00000418596ENST00000488445FAM126Bchr2

201910219

-COQ10Bchr2

198324656

+
5UTR-5UTRENST00000418596ENST00000409010FAM126Bchr2

201910219

-COQ10Bchr2

198324656

+
5UTR-5UTRENST00000418596ENST00000545340FAM126Bchr2

201910219

-COQ10Bchr2

198324656

+
5UTR-intronENST00000418596ENST00000409398FAM126Bchr2

201910219

-COQ10Bchr2

198324656

+
intron-3CDSENST00000485144ENST00000263960FAM126Bchr2

201910219

-COQ10Bchr2

198324656

+
intron-3UTRENST00000485144ENST00000488445FAM126Bchr2

201910219

-COQ10Bchr2

198324656

+
intron-5UTRENST00000485144ENST00000409010FAM126Bchr2

201910219

-COQ10Bchr2

198324656

+
intron-5UTRENST00000485144ENST00000545340FAM126Bchr2

201910219

-COQ10Bchr2

198324656

+
intron-intronENST00000485144ENST00000409398FAM126Bchr2

201910219

-COQ10Bchr2

198324656

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FAM126B-COQ10B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FAM126Bchr2201910218-COQ10Bchr2198324655+0.000101430.99989855
FAM126Bchr2201910218-COQ10Bchr2198324655+0.000101430.99989855


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FAM126B-COQ10B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:201910219/:198324656)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM126B

Q8IXS8

COQ10B

Q9H8M1

FUNCTION: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. {ECO:0000305|PubMed:26571211}.FUNCTION: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FAM126B-COQ10B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FAM126B-COQ10B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM126B-COQ10B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM126B-COQ10B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAM126BC0043094Weight Gain1CTD_human