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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GRID2-GNB2L1 (FusionGDB2 ID:HG2895TG10399)

Fusion Gene Summary for GRID2-GNB2L1

check button Fusion gene summary
Fusion gene informationFusion gene name: GRID2-GNB2L1
Fusion gene ID: hg2895tg10399
HgeneTgene
Gene symbol

GRID2

GNB2L1

Gene ID

2895

10399

Gene nameglutamate ionotropic receptor delta type subunit 2receptor for activated C kinase 1
SynonymsGluD2|SCAR18GNB2L1|Gnb2-rs1|H12.3|HLC-7|PIG21
Cytomap('GRID2')('GNB2L1')

4q22.1-q22.2

5q35.3

Type of geneprotein-codingprotein-coding
Descriptionglutamate receptor ionotropic, delta-2gluR delta-2 subunitglutamate receptor delta-2 subunitglutamate receptor, ionotropic, delta 2receptor of activated protein C kinase 1cell proliferation-inducing gene 21 proteinguanine nucleotide binding protein (G protein), beta polypeptide 2-like 1guanine nucleotide binding protein beta polypeptide 2-like 1guanine nucleotide-binding protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000282020, ENST00000505687, 
ENST00000510992, 
Fusion gene scores* DoF score14 X 15 X 3=63011 X 10 X 7=770
# samples 1512
** MAII scorelog2(15/630*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/770*10)=-2.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRID2 [Title/Abstract] AND GNB2L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRID2(93743194)-GNB2L1(180664039), # samples:19
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGNB2L1

GO:0001934

positive regulation of protein phosphorylation

11312657|17108144

TgeneGNB2L1

GO:0030308

negative regulation of cell growth

9584165

TgeneGNB2L1

GO:0030335

positive regulation of cell migration

20499158

TgeneGNB2L1

GO:0031334

positive regulation of protein complex assembly

20541605

TgeneGNB2L1

GO:0032091

negative regulation of protein binding

20541605

TgeneGNB2L1

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

19785988

TgeneGNB2L1

GO:0043065

positive regulation of apoptotic process

20541605

TgeneGNB2L1

GO:0043547

positive regulation of GTPase activity

20499158

TgeneGNB2L1

GO:0051726

regulation of cell cycle

9584165

TgeneGNB2L1

GO:0071333

cellular response to glucose stimulus

20103773

TgeneGNB2L1

GO:0071363

cellular response to growth factor stimulus

20010870



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LAMLTCGA-AB-2806-03AGRID2chr4

93743196

-GNB2L1chr5

180664041

-
ChimerDB4LAMLTCGA-AB-2819-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-2832-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-2844-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-2845-03BGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-2847-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-2862-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-2881-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-2887-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-2919-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-2924-03AGRID2chr4

93743196

-GNB2L1chr5

180664041

-
ChimerDB4LAMLTCGA-AB-2928-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-2949-03BGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-2964-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-2969-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-2986-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-2999-03BGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-3000-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-3007-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-
ChimerDB4LAMLTCGA-AB-3012-03AGRID2chr4

93743194

-GNB2L1chr5

180664039

-


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Fusion Gene ORF analysis for GRID2-GNB2L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000282020ENST00000376817GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000282020ENST00000376817GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000282020ENST00000504726GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000282020ENST00000504726GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000282020ENST00000511566GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000282020ENST00000511566GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000282020ENST00000511900GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000282020ENST00000511900GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000282020ENST00000512805GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000282020ENST00000512805GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000282020ENST00000514455GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000282020ENST00000514455GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000505687ENST00000376817GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000505687ENST00000376817GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000505687ENST00000504726GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000505687ENST00000504726GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000505687ENST00000511566GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000505687ENST00000511566GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000505687ENST00000511900GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000505687ENST00000511900GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000505687ENST00000512805GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000505687ENST00000512805GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000505687ENST00000514455GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000505687ENST00000514455GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000510992ENST00000376817GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000510992ENST00000376817GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000510992ENST00000504726GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000510992ENST00000504726GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000510992ENST00000511566GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000510992ENST00000511566GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000510992ENST00000511900GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000510992ENST00000511900GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000510992ENST00000512805GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000510992ENST00000512805GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-3CDSENST00000510992ENST00000514455GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-3CDSENST00000510992ENST00000514455GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-intronENST00000282020ENST00000456394GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-intronENST00000282020ENST00000456394GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-intronENST00000282020ENST00000505461GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-intronENST00000282020ENST00000505461GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-intronENST00000505687ENST00000456394GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-intronENST00000505687ENST00000456394GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-intronENST00000505687ENST00000505461GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-intronENST00000505687ENST00000505461GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-intronENST00000510992ENST00000456394GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-intronENST00000510992ENST00000456394GRID2chr4

93743194

-GNB2L1chr5

180664039

-
intron-intronENST00000510992ENST00000505461GRID2chr4

93743196

-GNB2L1chr5

180664041

-
intron-intronENST00000510992ENST00000505461GRID2chr4

93743194

-GNB2L1chr5

180664039

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GRID2-GNB2L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for GRID2-GNB2L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:93743194/:180664039)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GRID2-GNB2L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GRID2-GNB2L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GRID2-GNB2L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GRID2-GNB2L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRID2C4015505SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 185GENOMICS_ENGLAND;ORPHANET;UNIPROT