Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:RANGRF-LRP5 (FusionGDB2 ID:HG29098TG4041)

Fusion Gene Summary for RANGRF-LRP5

check button Fusion gene summary
Fusion gene informationFusion gene name: RANGRF-LRP5
Fusion gene ID: hg29098tg4041
HgeneTgene
Gene symbol

RANGRF

LRP5

Gene ID

29098

4041

Gene nameRAN guanine nucleotide release factorLDL receptor related protein 5
SynonymsHSPC165|HSPC236|MOG1|RANGNRFBMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP-7|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2
Cytomap('RANGRF')('LRP5')

17p13.1

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionran guanine nucleotide release factorMOG1 homologran-binding protein MOG1low-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000226105, ENST00000407006, 
ENST00000439238, ENST00000580434, 
Fusion gene scores* DoF score1 X 1 X 1=117 X 23 X 10=3910
# samples 127
** MAII scorelog2(1/1*10)=3.32192809488736log2(27/3910*10)=-3.85613729514388
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RANGRF [Title/Abstract] AND LRP5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRANGRF(8192732)-LRP5(68177382), # samples:1
Anticipated loss of major functional domain due to fusion event.RANGRF-LRP5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RANGRF-LRP5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RANGRF-LRP5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RANGRF-LRP5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRANGRF

GO:0003254

regulation of membrane depolarization

18184654

HgeneRANGRF

GO:0042391

regulation of membrane potential

18184654

HgeneRANGRF

GO:1902305

regulation of sodium ion transmembrane transport

18184654

HgeneRANGRF

GO:2000010

positive regulation of protein localization to cell surface

18184654

HgeneRANGRF

GO:2000649

regulation of sodium ion transmembrane transporter activity

18184654

TgeneLRP5

GO:0008284

positive regulation of cell proliferation

9790987

TgeneLRP5

GO:0045840

positive regulation of mitotic nuclear division

9790987

TgeneLRP5

GO:0045893

positive regulation of transcription, DNA-templated

15035989|17955262

TgeneLRP5

GO:0045944

positive regulation of transcription by RNA polymerase II

12857724

TgeneLRP5

GO:0060070

canonical Wnt signaling pathway

11029007|12121999|12857724|15908424|24706814|25920554


check buttonFusion gene breakpoints across RANGRF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LRP5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0CT-01ARANGRFchr17

8192732

+LRP5chr11

68177382

+


Top

Fusion Gene ORF analysis for RANGRF-LRP5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000226105ENST00000529481RANGRFchr17

8192732

+LRP5chr11

68177382

+
5CDS-intronENST00000407006ENST00000529481RANGRFchr17

8192732

+LRP5chr11

68177382

+
5CDS-intronENST00000439238ENST00000529481RANGRFchr17

8192732

+LRP5chr11

68177382

+
5CDS-intronENST00000580434ENST00000529481RANGRFchr17

8192732

+LRP5chr11

68177382

+
In-frameENST00000226105ENST00000294304RANGRFchr17

8192732

+LRP5chr11

68177382

+
In-frameENST00000407006ENST00000294304RANGRFchr17

8192732

+LRP5chr11

68177382

+
In-frameENST00000439238ENST00000294304RANGRFchr17

8192732

+LRP5chr11

68177382

+
In-frameENST00000580434ENST00000294304RANGRFchr17

8192732

+LRP5chr11

68177382

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000226105RANGRFchr178192732+ENST00000294304LRP5chr1168177382+360564329233991035
ENST00000407006RANGRFchr178192732+ENST00000294304LRP5chr1168177382+344848613532421035
ENST00000580434RANGRFchr178192732+ENST00000294304LRP5chr1168177382+343146911832251035
ENST00000439238RANGRFchr178192732+ENST00000294304LRP5chr1168177382+394598310013739912

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000226105ENST00000294304RANGRFchr178192732+LRP5chr1168177382+0.0010651450.9989348
ENST00000407006ENST00000294304RANGRFchr178192732+LRP5chr1168177382+0.0009535150.9990465
ENST00000580434ENST00000294304RANGRFchr178192732+LRP5chr1168177382+0.000971450.99902856
ENST00000439238ENST00000294304RANGRFchr178192732+LRP5chr1168177382+0.0012822710.9987178

Top

Fusion Genomic Features for RANGRF-LRP5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RANGRFchr178192732+LRP5chr1168177381+6.98E-101
RANGRFchr178192732+LRP5chr1168177381+6.98E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for RANGRF-LRP5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:8192732/chr11:68177382)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231495_16106971616.0Compositional biasNote=Pro-rich
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231213_12546971616.0DomainNote=EGF-like 4
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231258_12966971616.0DomainLDL-receptor class A 1
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231297_13336971616.0DomainLDL-receptor class A 2
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231335_13716971616.0DomainLDL-receptor class A 3
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823902_9426971616.0DomainNote=EGF-like 3
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231500_15066971616.0MotifNote=PPPSP motif A
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231538_15456971616.0MotifNote=PPPSP motif B
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231574_15816971616.0MotifNote=PPPSP motif C
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231591_15966971616.0MotifNote=PPPSP motif D
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231605_16126971616.0MotifNote=PPPSP motif E
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823945_12126971616.0RegionNote=Beta-propeller 4
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231036_10786971616.0RepeatNote=LDL-receptor class B 17
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231079_11236971616.0RepeatNote=LDL-receptor class B 18
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231124_11646971616.0RepeatNote=LDL-receptor class B 19
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231165_12076971616.0RepeatNote=LDL-receptor class B 20
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823730_7726971616.0RepeatNote=LDL-receptor class B 12
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823773_8156971616.0RepeatNote=LDL-receptor class B 13
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823816_8556971616.0RepeatNote=LDL-receptor class B 14
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823819_8226971616.0RepeatNote=YWTD 10
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823856_8986971616.0RepeatNote=LDL-receptor class B 15
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823859_8626971616.0RepeatNote=YWTD 11
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823989_10356971616.0RepeatNote=LDL-receptor class B 16
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231408_16156971616.0Topological domainCytoplasmic
TgeneLRP5chr17:8192732chr11:68177382ENST000002943048231385_14076971616.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823295_3376971616.0DomainNote=EGF-like 1
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823601_6416971616.0DomainNote=EGF-like 2
TgeneLRP5chr17:8192732chr11:68177382ENST0000029430482332_2886971616.0RegionNote=Beta-propeller 1
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823341_6026971616.0RegionNote=Beta-propeller 2
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823644_9036971616.0RegionNote=Beta-propeller 3
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823120_1626971616.0RepeatNote=LDL-receptor class B 2
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823123_1266971616.0RepeatNote=YWTD 2
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823163_2066971616.0RepeatNote=LDL-receptor class B 3
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823166_1696971616.0RepeatNote=YWTD 3
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823207_2476971616.0RepeatNote=LDL-receptor class B 4
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823248_2906971616.0RepeatNote=LDL-receptor class B 5
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823251_2546971616.0RepeatNote=YWTD 4
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823385_4276971616.0RepeatNote=LDL-receptor class B 6
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823388_3916971616.0RepeatNote=YWTD 5
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823428_4706971616.0RepeatNote=LDL-receptor class B 7
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823431_4346971616.0RepeatNote=YWTD 6
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823471_5146971616.0RepeatNote=LDL-receptor class B 8
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823474_4776971616.0RepeatNote=YWTD 7
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823515_5576971616.0RepeatNote=LDL-receptor class B 9
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823558_6006971616.0RepeatNote=LDL-receptor class B 10
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823559_5626971616.0RepeatNote=YWTD 8
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823687_7296971616.0RepeatNote=LDL-receptor class B 11
TgeneLRP5chr17:8192732chr11:68177382ENST00000294304823690_6936971616.0RepeatNote=YWTD 9
TgeneLRP5chr17:8192732chr11:68177382ENST0000029430482375_1196971616.0RepeatNote=LDL-receptor class B 1
TgeneLRP5chr17:8192732chr11:68177382ENST0000029430482378_816971616.0RepeatNote=YWTD 1
TgeneLRP5chr17:8192732chr11:68177382ENST0000029430482332_13846971616.0Topological domainExtracellular


Top

Fusion Gene Sequence for RANGRF-LRP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72123_72123_1_RANGRF-LRP5_RANGRF_chr17_8192732_ENST00000226105_LRP5_chr11_68177382_ENST00000294304_length(transcript)=3605nt_BP=643nt
GGGGGCGACATAGACCCTAACCCTAAGTCCAACCCCAAGGCAGACCCCACCGTCCCGCCAGGCGCACTCCTAAGAGCGCGGCTTCCGGAG
CAAAGCCGCTGACCCCCGCCCCCAGGGTCTTGGCGCCGATTGGCCAACGAGAGCGCAGGGCGGAGCCAAATCTTAAAGGATCCGGGAGCT
AAGCCAGACCCGGGTGGCGGTGGCAGCTGCGAAACCCAGGGAGCCGATGCCACGTGACCCAATGTGGACTTCTTTTAAACCTTTCTAATG
CCCATAACCCAGCCTCAGACCCATGGAGCCCACGAGAGACTGCCCGCTGTTCGGGGGCGCCTTTTCCGCCATCCTCCCCATGGGGGCCAT
TGACGTAAGCGACCTCCGACCGGTCCCGGACAATCAAGAAGTTTTCTGCCATCCCGTGACGGACCAGAGCCTGATAGTGGAACTTCTCGA
GCTGCAGGCCCACGTACGGGGCGAAGCGGCTGCGCGGTACCACTTTGAGGATGTTGGTGGCGTGCAGGGGGCTAGGGCTGTCCATGTGGA
GTCTGTTCAGCCTCTCAGTTTGGAGAACCTGGCCCTGAGGGGCCGCTGTCAAGAAGCCTGGGTCCTCTCTGGCAAGCAGCAGATAGCTAA
GGAAAACCAGCAGACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCCGAGGGCAT
GGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAGTTCCGGCA
AGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGGGGCGGCAA
GCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACCATTGACTA
CGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTGATTGCCGA
CGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAA
GACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCT
CAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACAC
CCTGGACCCCAGCAGCCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGA
CCAGCACAGCCCGGATCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTG
GGTGGATGGGCGCCAGAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGA
CAGGCAGCCCCACGACCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCT
GAGCGGGGAAGCCATGGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTT
CACCAACATGCAGGACCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCG
CCCTGTGGCCCTGGTGGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGG
GGCCAACCGCCTGACCCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCA
GCAGCAGATGATCGAGCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGC
AGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGA
TGGGACACCACGGTGCTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCA
GTTTGCATGTGCCACAGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGA
GGGCTGCCCCGTGTGCTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTG
TCAGGACCGCTCAGACGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACA
GCAGTGCGACTCCTTCCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCA
CAGCAGTGCCATCGGGCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCA
GCGCTATGCGGGGGCCAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTC
CCAGCATGGCCCCTTCACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTA
CGACCGGAACCACGTCACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTC
CCCGGCCACGGACCCCTCCCTGTACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCAT
TCGAGGAATGGCGCCCCCGACGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTA
CCTGGATTTGAACTCGGACTCAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTC
GCCCGCCACCGAGAGGAGCTACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATCCTGACCTCGGCCGGGCCACTCTGG
CTTCTCTGTGCCCCTGTAAATAGTTTTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAAAAATAAATATAATTGGGATTTTAA
AAACATGAGAAATGTGAACTGTGATGGGGTGGGCAGGGCTGGGAGAACTTTGTACAGTGGAGAAATATTTATAAACTTAATTTTGTAAAA

>72123_72123_1_RANGRF-LRP5_RANGRF_chr17_8192732_ENST00000226105_LRP5_chr11_68177382_ENST00000294304_length(amino acids)=1035AA_BP=116
MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSL
ENLALRGRCQEAWVLSGKQQIAKENQQTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDL
DNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFG
LTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRN
CSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLS
IDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVD
NTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLE
EFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSA
AQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPV
IGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTG
ASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDS

--------------------------------------------------------------
>72123_72123_2_RANGRF-LRP5_RANGRF_chr17_8192732_ENST00000407006_LRP5_chr11_68177382_ENST00000294304_length(transcript)=3448nt_BP=486nt
AAATCTTAAAGGATCCGGGAGCTAAGCCAGACCCGGGTGGCGGTGGCAGCTGCGAAACCCAGGGAGCCGATGCCACGTGACCCAATGTGG
ACTTCTTTTAAACCTTTCTAATGCCCATAACCCAGCCTCAGACCCATGGAGCCCACGAGAGACTGCCCGCTGTTCGGGGGCGCCTTTTCC
GCCATCCTCCCCATGGGGGCCATTGACGTAAGCGACCTCCGACCGGTCCCGGACAATCAAGAAGTTTTCTGCCATCCCGTGACGGACCAG
AGCCTGATAGTGGAACTTCTCGAGCTGCAGGCCCACGTACGGGGCGAAGCGGCTGCGCGGTACCACTTTGAGGATGTTGGTGGCGTGCAG
GGGGCTAGGGCTGTCCATGTGGAGTCTGTTCAGCCTCTCAGTTTGGAGAACCTGGCCCTGAGGGGCCGCTGTCAAGAAGCCTGGGTCCTC
TCTGGCAAGCAGCAGATAGCTAAGGAAAACCAGCAGACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTT
GGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGCG
CGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACATC
TACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCGG
GCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGGT
CAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTG
CACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTC
CACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGC
TGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCC
ATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGAC
CCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCT
CTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACC
AATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAAC
GCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTC
CTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGC
ATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAG
CATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTC
GCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCC
CACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAG
CCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAG
TGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTG
CGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGC
GGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCG
CCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTT
GTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTC
AATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGG
GGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCG
CCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCCTGTACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCG
AGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGACGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGC
CGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACTCAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCG
GCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCTACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATCC
TGACCTCGGCCGGGCCACTCTGGCTTCTCTGTGCCCCTGTAAATAGTTTTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAAA
AATAAATATAATTGGGATTTTAAAAACATGAGAAATGTGAACTGTGATGGGGTGGGCAGGGCTGGGAGAACTTTGTACAGTGGAGAAATA

>72123_72123_2_RANGRF-LRP5_RANGRF_chr17_8192732_ENST00000407006_LRP5_chr11_68177382_ENST00000294304_length(amino acids)=1035AA_BP=116
MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSL
ENLALRGRCQEAWVLSGKQQIAKENQQTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDL
DNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFG
LTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRN
CSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLS
IDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVD
NTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLE
EFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSA
AQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPV
IGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTG
ASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDS

--------------------------------------------------------------
>72123_72123_3_RANGRF-LRP5_RANGRF_chr17_8192732_ENST00000439238_LRP5_chr11_68177382_ENST00000294304_length(transcript)=3945nt_BP=983nt
AGCCAGACCCGGGTGGCGGTGGCAGCTGCGAAACCCAGGGAGCCGATGCCACGTGACCCAATGTGGACTTCTTTTAAACCTTTCTAATGC
CCATAACCCAGCCTCAGACCCATGGAGCCCACGAGAGACTGCCCGCTGTTCGGGGGCGCCTTTTCCGCCATCCTCCCCATGGGGGCCATT
GACGTAAGCGACCTCCGACCGGTCCCGGACAATCAAGAAGTTTTCTGCCATCCCGTGACGGACCAGAGCCTGATAGTGGAACTTCTCGAG
CTGCAGGCCCACGTACGGGGCGAAGCGGCTGCGCGGTGAGGGCCCGAGAGTGTGTAATGTCCTGGAAGGGCGGTAGCGGGGACGCAGAGA
TCCAGGTAAGCATCCTGACTCTGATCCCCTTAGGTAGCAAAGGACGTGACACTTCATCAGGCCTTGCTGAGGCTGCCCCAGTACCAGACT
GATCTCTTGCTTACCTTCAATCAGCCCCCGTAAGGAGGAAGGAACGGGCGGGTATCTCATGACTGGGTTCCCAGGAGAATCGGGCTGGGA
GGGACAGAACAGGGAGACTCACTGGTGGGATCCTCCAAGGAAGCAGGAGTGGGCCAGAGGTTTGGGGTAACTGATACCCAGGTCCTCTGG
GGAACAGGAATTGGCAATTTCCAAACCTCAGGCCTGGATGATGTTCTGTCTCCATCTGTTCCCCCACCCCAAGCCCTGACAACAGGTCAT
CTCTTGGCCCCGAAAATCTGTCACCTGCACCCTGGAGCCTGGGTGACTTTGAACAGCTGGTGACCAGTCTGACCCTTCACGATCCTAACA
TCTTTGGTCCCCAGTAAAGGCGCTGAAGCACTGCATGATGTTGCTGAGAACTTGGGGACTCGGTTCTGTGAGGGGGAAAAGAGGTTGAAA
AGAGGGTTTCCTCTTATTTCTTCCCTGTGCGTAAACATAAGACAATCCCTCTTCAGAATAAACTTGCTTTATAATCAATATAAACCATCA
GCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCA
AGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACT
TGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCT
TCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACT
GGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCG
GTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCA
CCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACA
ACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCA
ACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCA
TCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACA
TCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCA
GCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGG
TGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGG
CAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGG
ACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGG
AGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTG
TGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGG
AGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCAT
GCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGG
AGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCG
CCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGG
CGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCG
ACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCG
TCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACG
GGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAG
GCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAG
GGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCC
TGTACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGA
CGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACT
CAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCT
ACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATCCTGACCTCGGCCGGGCCACTCTGGCTTCTCTGTGCCCCTGTAAA
TAGTTTTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAAAAATAAATATAATTGGGATTTTAAAAACATGAGAAATGTGAACT

>72123_72123_3_RANGRF-LRP5_RANGRF_chr17_8192732_ENST00000439238_LRP5_chr11_68177382_ENST00000294304_length(amino acids)=912AA_BP=
MNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDG
TNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQ
GHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPL
HGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLR
GDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDAN
IVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVH
LVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCD
AICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFP
HEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNM
DMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHL

--------------------------------------------------------------
>72123_72123_4_RANGRF-LRP5_RANGRF_chr17_8192732_ENST00000580434_LRP5_chr11_68177382_ENST00000294304_length(transcript)=3431nt_BP=469nt
GGAGCTAAGCCAGACCCGGGTGGCGGTGGCAGCTGCGAAACCCAGGGAGCCGATGCCACGTGACCCAATGTGGACTTCTTTTAAACCTTT
CTAATGCCCATAACCCAGCCTCAGACCCATGGAGCCCACGAGAGACTGCCCGCTGTTCGGGGGCGCCTTTTCCGCCATCCTCCCCATGGG
GGCCATTGACGTAAGCGACCTCCGACCGGTCCCGGACAATCAAGAAGTTTTCTGCCATCCCGTGACGGACCAGAGCCTGATAGTGGAACT
TCTCGAGCTGCAGGCCCACGTACGGGGCGAAGCGGCTGCGCGGTACCACTTTGAGGATGTTGGTGGCGTGCAGGGGGCTAGGGCTGTCCA
TGTGGAGTCTGTTCAGCCTCTCAGTTTGGAGAACCTGGCCCTGAGGGGCCGCTGTCAAGAAGCCTGGGTCCTCTCTGGCAAGCAGCAGAT
AGCTAAGGAAAACCAGCAGACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCCGA
GGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAGTT
CCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGGGG
CGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACCAT
TGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTGAT
TGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGC
CGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGA
TGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACA
CTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCC
GGACGACCAGCACAGCCCGGATCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCAT
CTACTGGGTGGATGGGCGCCAGAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAA
CCCAGACAGGCAGCCCCACGACCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCA
CAGGCTGAGCGGGGAAGCCATGGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCT
GTACTTCACCAACATGCAGGACCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCT
CATCCGCCCTGTGGCCCTGGTGGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCT
GTCAGGGGCCAACCGCCTGACCCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGA
CCGCCAGCAGCAGATGATCGAGCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCAT
CCATGCAGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAA
GGGTGATGGGACACCACGGTGCTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCC
GGACCAGTTTGCATGTGCCACAGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGA
CGAGGAGGGCTGCCCCGTGTGCTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGC
AGACTGTCAGGACCGCTCAGACGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCAT
CAAACAGCAGTGCGACTCCTTCCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCC
GGCCCACAGCAGTGCCATCGGGCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGT
GTGCCAGCGCTATGCGGGGGCCAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGG
CGGTTCCCAGCATGGCCCCTTCACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCC
CCTCTACGACCGGAACCACGTCACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCC
GCCCTCCCCGGCCACGGACCCCTCCCTGTACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTA
CATCATTCGAGGAATGGCGCCCCCGACGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAA
GTACTACCTGGATTTGAACTCGGACTCAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCC
GCCCTCGCCCGCCACCGAGAGGAGCTACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATCCTGACCTCGGCCGGGCCA
CTCTGGCTTCTCTGTGCCCCTGTAAATAGTTTTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAAAAATAAATATAATTGGGA
TTTTAAAAACATGAGAAATGTGAACTGTGATGGGGTGGGCAGGGCTGGGAGAACTTTGTACAGTGGAGAAATATTTATAAACTTAATTTT

>72123_72123_4_RANGRF-LRP5_RANGRF_chr17_8192732_ENST00000580434_LRP5_chr11_68177382_ENST00000294304_length(amino acids)=1035AA_BP=116
MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSL
ENLALRGRCQEAWVLSGKQQIAKENQQTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDL
DNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFG
LTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRN
CSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLS
IDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVD
NTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLE
EFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSA
AQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPV
IGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTG
ASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RANGRF-LRP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneRANGRFchr17:8192732chr11:68177382ENST00000226105+3527_70117.0187.0RAN
HgeneRANGRFchr17:8192732chr11:68177382ENST00000407006+3427_70117.0147.0RAN
HgeneRANGRFchr17:8192732chr11:68177382ENST00000580434+3427_70117.0119.0RAN


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRANGRFchr17:8192732chr11:68177382ENST00000439238+1327_700166.0RAN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for RANGRF-LRP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for RANGRF-LRP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRANGRFC1142166Brugada Syndrome (disorder)6CLINGEN;ORPHANET
HgeneRANGRFC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneC1866176EXUDATIVE VITREORETINOPATHY 4 (disorder)10CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0432252Osteoporosis with pseudoglioma8CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC1866079BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 16GENOMICS_ENGLAND;UNIPROT
TgeneC1843330OSTEOPETROSIS, AUTOSOMAL DOMINANT 14CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC4693479POLYCYSTIC LIVER DISEASE 4 WITH OR WITHOUT KIDNEY CYSTS3GENOMICS_ENGLAND;UNIPROT
TgeneC0432273Worth disease2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC1843323Van Buchem disease type 22CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0015397Disorder of eye1GENOMICS_ENGLAND
TgeneC0035344Retinopathy of Prematurity1ORPHANET
TgeneC0151879Shortened QT interval1GENOMICS_ENGLAND
TgeneC0158683Polycystic liver disease1ORPHANET
TgeneC0242852Proliferative vitreoretinopathy1CTD_human
TgeneC0339539Familial Exudative Vitreoretinopathy1CTD_human
TgeneC0432272Van Buchem disease1ORPHANET
TgeneC1851402Exudative vitreoretinopathy 11CTD_human;UNIPROT