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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRD7-ZNF423 (FusionGDB2 ID:HG29117TG23090)

Fusion Gene Summary for BRD7-ZNF423

check button Fusion gene summary
Fusion gene informationFusion gene name: BRD7-ZNF423
Fusion gene ID: hg29117tg23090
HgeneTgene
Gene symbol

BRD7

ZNF423

Gene ID

29117

23090

Gene namebromodomain containing 7zinc finger protein 423
SynonymsBP75|CELTIX1|NAG4Ebfaz|JBTS19|NPHP14|OAZ|Roaz|ZFP423|Zfp104|hOAZ
Cytomap('BRD7')('ZNF423')

16q12.1

16q12.1

Type of geneprotein-codingprotein-coding
Descriptionbromodomain-containing protein 775 kDa bromodomain proteinprotein CELTIX-1zinc finger protein 423OLF-1/EBF associated zinc fingerSmad- and Olf-interacting zinc finger proteinearly B-cell factor associated zinc finger proteinolf1/EBF-associated zinc finger protein
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000401491, ENST00000394688, 
ENST00000394689, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 5 X 6=180
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRD7 [Title/Abstract] AND ZNF423 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRD7(50388336)-ZNF423(49559405), # samples:2
Anticipated loss of major functional domain due to fusion event.BRD7-ZNF423 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
BRD7-ZNF423 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BRD7-ZNF423 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
BRD7-ZNF423 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
BRD7-ZNF423 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
BRD7-ZNF423 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRD7

GO:0006357

regulation of transcription by RNA polymerase II

12489984

HgeneBRD7

GO:0008285

negative regulation of cell proliferation

20228809

HgeneBRD7

GO:0035066

positive regulation of histone acetylation

20228809

HgeneBRD7

GO:0045892

negative regulation of transcription, DNA-templated

16265664

HgeneBRD7

GO:0045893

positive regulation of transcription, DNA-templated

20228809

HgeneBRD7

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

16265664

TgeneZNF423

GO:0045892

negative regulation of transcription, DNA-templated

10660046

TgeneZNF423

GO:0045893

positive regulation of transcription, DNA-templated

10660046



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-Z7-A8R6-01ABRD7chr16

50388336

-ZNF423chr16

49559405

-


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Fusion Gene ORF analysis for BRD7-ZNF423

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000401491ENST00000262383BRD7chr16

50388336

-ZNF423chr16

49559405

-
5UTR-3CDSENST00000401491ENST00000535559BRD7chr16

50388336

-ZNF423chr16

49559405

-
5UTR-3CDSENST00000401491ENST00000561648BRD7chr16

50388336

-ZNF423chr16

49559405

-
5UTR-3CDSENST00000401491ENST00000562520BRD7chr16

50388336

-ZNF423chr16

49559405

-
5UTR-3CDSENST00000401491ENST00000562871BRD7chr16

50388336

-ZNF423chr16

49559405

-
5UTR-3CDSENST00000401491ENST00000563137BRD7chr16

50388336

-ZNF423chr16

49559405

-
5UTR-3CDSENST00000401491ENST00000567169BRD7chr16

50388336

-ZNF423chr16

49559405

-
Frame-shiftENST00000394688ENST00000262383BRD7chr16

50388336

-ZNF423chr16

49559405

-
Frame-shiftENST00000394688ENST00000535559BRD7chr16

50388336

-ZNF423chr16

49559405

-
Frame-shiftENST00000394688ENST00000561648BRD7chr16

50388336

-ZNF423chr16

49559405

-
Frame-shiftENST00000394688ENST00000562520BRD7chr16

50388336

-ZNF423chr16

49559405

-
Frame-shiftENST00000394688ENST00000562871BRD7chr16

50388336

-ZNF423chr16

49559405

-
Frame-shiftENST00000394688ENST00000563137BRD7chr16

50388336

-ZNF423chr16

49559405

-
Frame-shiftENST00000394688ENST00000567169BRD7chr16

50388336

-ZNF423chr16

49559405

-
Frame-shiftENST00000394689ENST00000262383BRD7chr16

50388336

-ZNF423chr16

49559405

-
Frame-shiftENST00000394689ENST00000535559BRD7chr16

50388336

-ZNF423chr16

49559405

-
Frame-shiftENST00000394689ENST00000561648BRD7chr16

50388336

-ZNF423chr16

49559405

-
Frame-shiftENST00000394689ENST00000562520BRD7chr16

50388336

-ZNF423chr16

49559405

-
Frame-shiftENST00000394689ENST00000562871BRD7chr16

50388336

-ZNF423chr16

49559405

-
Frame-shiftENST00000394689ENST00000563137BRD7chr16

50388336

-ZNF423chr16

49559405

-
Frame-shiftENST00000394689ENST00000567169BRD7chr16

50388336

-ZNF423chr16

49559405

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for BRD7-ZNF423


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for BRD7-ZNF423


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:50388336/:49559405)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for BRD7-ZNF423


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for BRD7-ZNF423


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRD7-ZNF423


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRD7-ZNF423


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0236733Amphetamine-Related Disorders1CTD_human
TgeneC0236804Amphetamine Addiction1CTD_human
TgeneC0236807Amphetamine Abuse1CTD_human
TgeneC1855675Arima syndrome1GENOMICS_ENGLAND;ORPHANET
TgeneC1865872NEPHRONOPHTHISIS 21ORPHANET
TgeneC3539071NEPHRONOPHTHISIS 141CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC3553846JOUBERT SYNDROME 191GENOMICS_ENGLAND