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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GSN-RGS11 (FusionGDB2 ID:HG2934TG8786)

Fusion Gene Summary for GSN-RGS11

check button Fusion gene summary
Fusion gene informationFusion gene name: GSN-RGS11
Fusion gene ID: hg2934tg8786
HgeneTgene
Gene symbol

GSN

RGS11

Gene ID

2934

8786

Gene namegelsolinregulator of G protein signaling 11
SynonymsADF|AGELRS11
Cytomap('GSN')('RGS11')

9q33.2

16p13.3

Type of geneprotein-codingprotein-coding
Descriptiongelsolinactin-depolymerizing factorbrevinepididymis secretory sperm binding proteinregulator of G-protein signaling 11regulator of G-protein signalling 11
Modification date2020032920200313
UniProtAcc

P06396

.
Ensembl transtripts involved in fusion geneENST00000341272, ENST00000373807, 
ENST00000373808, ENST00000373818, 
ENST00000373823, ENST00000394353, 
ENST00000412819, ENST00000436847, 
ENST00000449733, ENST00000545652, 
ENST00000373806, ENST00000485767, 
Fusion gene scores* DoF score21 X 16 X 8=26882 X 3 X 2=12
# samples 242
** MAII scorelog2(24/2688*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GSN [Title/Abstract] AND RGS11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGSN(124088808)-RGS11(319123), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGSN

GO:0030041

actin filament polymerization

3020431

HgeneGSN

GO:0051014

actin filament severing

3020431



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for GSN-RGS11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GSN-RGS11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for GSN-RGS11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:124088808/:319123)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSN

P06396

.
FUNCTION: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. {ECO:0000269|PubMed:20393563}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GSN-RGS11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GSN-RGS11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GSN-RGS11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGSNP06396DB01593ZincSmall moleculeApproved|Investigational
HgeneGSNP06396DB09130CopperSmall moleculeApproved|Investigational
HgeneGSNP06396DB14487Zinc acetateSmall moleculeApproved|Investigational

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Related Diseases for GSN-RGS11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGSNC1622345Meretoja syndrome6CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneGSNC0936273Familial Amyloid Polyneuropathy, Type IV3ORPHANET
HgeneGSNC0001787Osteoporosis, Age-Related1CTD_human
HgeneGSNC0002726Amyloidosis1GENOMICS_ENGLAND
HgeneGSNC0018800Cardiomegaly1CTD_human
HgeneGSNC0019193Hepatitis, Toxic1CTD_human
HgeneGSNC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneGSNC0025500Mesothelioma1CTD_human
HgeneGSNC0029456Osteoporosis1CTD_human
HgeneGSNC0029459Osteoporosis, Senile1CTD_human
HgeneGSNC0030524Paratuberculosis1CTD_human
HgeneGSNC0036341Schizophrenia1PSYGENET
HgeneGSNC0043094Weight Gain1CTD_human
HgeneGSNC0268389Amyloidosis, familial visceral1GENOMICS_ENGLAND
HgeneGSNC0751406Post-Traumatic Osteoporosis1CTD_human
HgeneGSNC0860207Drug-Induced Liver Disease1CTD_human
HgeneGSNC0948089Acute Coronary Syndrome1CTD_human
HgeneGSNC1262760Hepatitis, Drug-Induced1CTD_human
HgeneGSNC1383860Cardiac Hypertrophy1CTD_human
HgeneGSNC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneGSNC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneGSNC4279912Chemically-Induced Liver Toxicity1CTD_human