Fusion Gene Studies
in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BLNK-PROSC (FusionGDB2 ID:HG29760TG11212)

Fusion Gene Summary for BLNK-PROSC

check button Fusion gene summary
Fusion gene informationFusion gene name: BLNK-PROSC
Fusion gene ID: hg29760tg11212
HgeneTgene
Gene symbol

BLNK

PROSC

Gene ID

29760

11212

Gene nameB cell linkerpyridoxal phosphate binding protein
SynonymsAGM4|BASH|BLNK-S|LY57|SLP-65|SLP65|bcaEPVB6D|PROSC
Cytomap('BLNK')('PROSC')

10q24.1

8p11.23

Type of geneprotein-codingprotein-coding
DescriptionB-cell linker proteinB cell adaptor containing SH2 domainB-cell activationB-cell adapter containing a SH2 domain proteinB-cell adapter containing a Src homology 2 domain proteinSrc homology 2 domain-containing leukocyte protein of 65 kDaSrc homologypyridoxal phosphate homeostasis proteinPLP homeostasis proteinproline synthase co-transcribed bacterial homolog proteinproline synthetase co-transcribed bacterial homolog protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000224337, ENST00000371176, 
ENST00000413476, ENST00000427367, 
ENST00000495266, 
Fusion gene scores* DoF score7 X 6 X 6=2526 X 6 X 5=180
# samples 77
** MAII scorelog2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BLNK [Title/Abstract] AND PROSC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBLNK(98031109)-PROSC(37623044), # samples:1
Anticipated loss of major functional domain due to fusion event.BLNK-PROSC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BLNK-PROSC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBLNK

GO:0035556

intracellular signal transduction

9341187


check buttonFusion gene breakpoints across BLNK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PROSC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AX-A05S-01ABLNKchr10

98031109

-PROSCchr8

37623044

+


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Fusion Gene ORF analysis for BLNK-PROSC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000224337ENST00000328195BLNKchr10

98031109

-PROSCchr8

37623044

+
In-frameENST00000371176ENST00000328195BLNKchr10

98031109

-PROSCchr8

37623044

+
In-frameENST00000413476ENST00000328195BLNKchr10

98031109

-PROSCchr8

37623044

+
In-frameENST00000427367ENST00000328195BLNKchr10

98031109

-PROSCchr8

37623044

+
In-frameENST00000495266ENST00000328195BLNKchr10

98031109

-PROSCchr8

37623044

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000224337BLNKchr1098031109-ENST00000328195PROSCchr837623044+2579189246917223
ENST00000371176BLNKchr1098031109-ENST00000328195PROSCchr837623044+2579189246917223
ENST00000427367BLNKchr1098031109-ENST00000328195PROSCchr837623044+2615225282953223
ENST00000413476BLNKchr1098031109-ENST00000328195PROSCchr837623044+2615225282953223
ENST00000495266BLNKchr1098031109-ENST00000328195PROSCchr837623044+243747104775223

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000224337ENST00000328195BLNKchr1098031109-PROSCchr837623044+0.0013092280.9986908
ENST00000371176ENST00000328195BLNKchr1098031109-PROSCchr837623044+0.0013092280.9986908
ENST00000427367ENST00000328195BLNKchr1098031109-PROSCchr837623044+0.0015608490.99843913
ENST00000413476ENST00000328195BLNKchr1098031109-PROSCchr837623044+0.0015608490.99843913
ENST00000495266ENST00000328195BLNKchr1098031109-PROSCchr837623044+0.0013639140.99863607

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Fusion Genomic Features for BLNK-PROSC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BLNKchr1098031108-PROSCchr837623043+8.96E-060.99999106
BLNKchr1098031108-PROSCchr837623043+8.96E-060.99999106

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BLNK-PROSC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:98031109/chr8:37623044)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBLNKchr10:98031109chr8:37623044ENST00000224337-11798_26015457.0Compositional biasNote=Pro-rich
HgeneBLNKchr10:98031109chr8:37623044ENST00000371176-11698_26015434.0Compositional biasNote=Pro-rich
HgeneBLNKchr10:98031109chr8:37623044ENST00000413476-11698_26015405.0Compositional biasNote=Pro-rich
HgeneBLNKchr10:98031109chr8:37623044ENST00000224337-117346_45315457.0DomainSH2
HgeneBLNKchr10:98031109chr8:37623044ENST00000371176-116346_45315434.0DomainSH2
HgeneBLNKchr10:98031109chr8:37623044ENST00000413476-116346_45315405.0DomainSH2


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Fusion Gene Sequence for BLNK-PROSC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9812_9812_1_BLNK-PROSC_BLNK_chr10_98031109_ENST00000224337_PROSC_chr8_37623044_ENST00000328195_length(transcript)=2579nt_BP=189nt
GCAGCCTGCACTCTCAGAAATCAGACTTGAGTGGCCGGAACCCTTGAGACCAGAGGCTTACCATGCTGCTCCCTAGGAGGGCCAGGAACT
GCTGACGTGACCACTGGACAGTTATTCGTGTCTCTTACAATTACCAAACAGAATGGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCA
GAAGTTGAGGATCTCCCAGCCATCCAGCCCCGGCTAGTGGCGGTCAGCAAAACCAAACCTGCAGACATGGTGATCGAGGCCTATGGACAT
GGGCAGCGCACTTTTGGCGAGAACTACGTTCAGGAACTGCTAGAAAAAGCATCAAATCCCAAAATTCTGTCTTTGTGTCCTGAGATCAAA
TGGCACTTCATTGGCCACCTACAGAAACAAAATGTCAACAAATTGATGGCTGTCCCCAATCTCTTCATGCTGGAAACAGTGGATTCTGTG
AAGTTGGCAGACAAAGTGAACAGTTCCTGGCAGAGAAAAGGTTCTCCTGAAAGGTTAAAGGTTATGGTCCAGATTAACACCAGCGGAGAA
GAGAGTAAACATGGCCTTCCACCTTCAGAGACCATAGCCATCGTGGAGCACATAAACGCCAAGTGTCCTAACCTGGAGTTTGTGGGGCTG
ATGACCATAGGAAGCTTTGGGCATGATCTTAGTCAAGGACCAAATCCAGACTTCCAGCTGTTATTGTCCCTCCGGGAGGAGCTGTGTAAA
AAGCTGAACATCCCTGCTGACCAGGTTGAGCTGAGCATGGGCATGTCCGCGGATTTCCAGCATGCGGTTGAAGTAGGATCTACAAATGTC
CGAATAGGAAGCACGATTTTTGGAGAGCGGGATTACTCAAAGAAACCCACCCCGGACAAGTGCGCAGCAGACGTGAAGGCCCCGCTGGAG
GTGGCACAGGAGCACTGAGCCAGGGAATACTGAGAGCACTAACTATGCACTAACCTAGATTTTCATTTCGATATTCCCTGTGTCCCAGCG
CAGTCCTGCTCTCCTGTGACCTGTGGAGAGCACTAATGATCACGTGTGTTGATGGAAACCATCTGTGCTTAGTCTCTGACATAGGAAGCT
TGCTTCAGGCAATGGCTTTGGATTGAGTTTGAGAAATTCAAACATTTCTGCAGAACAGATACCAAATCAATAGCTAGGAATCATGTTCAA
TATTGAATTCTGCCCAGGAGCATGAACTGATCCATGAATGCCTTTTCCAGGTTAAAATTTGGTCACTGATGCCTATAATCGTGGAAGTCA
GAGGGATTCCCCTTTTTCATCTCATTTTAATAGGAAAATTCCTTATGGTTAACATCTCCCTACAAACTCCTACTACGTCGTCTAAATTGC
TGCTCTGGAATAAGGTGATTTCTGCCCCCAGATTCTTCCCTAGCCGGTAGATACGTGAAGATATTCCCAACTGTGGAATGGCAGTGTAGG
TAGCTTCAGGAAATGGCTCAGGTTAATTCTCAAAACACAAATTGTTGCTGGCCAGGCATGGTGACTCATGCCTGTAATCCCAGCAATTTG
GGAGACAGAGGCGGAAGGATCACCTGAGCCTAGGAGTTCAAGACCAGCCTCAGCAACAGCAGGAGCCCCACCCCCCGTCTCTACAAAAAA
ATTTAAAAATTAACTGGGCATGGTGGCTGAGGTGGAAGAATGGAAGAATCACTTGAGCCCAGGAGTTTGAGGCTGCAGTGAGCTATGATT
GCACCACTGTACTCCTGCCTTAAAAAAAAAAAAAAAATCCCAATAGTCCATGAAGGCTTTGATCTCTTGGGAAGTTCTTCATAGATGCTG
TCACATTTCTTAAAGCAACCTTTTAATATGCAGATAATACCCCCCAACTTTTTTAGAGACAGCCTGTCTCTTAAAAAAAAAATTAATTTG
GTAGTGAGAGCTTGTGTCACTGCCACTCTGTTTTATCCCTGAAATTAAAGGATAACATAAGGAGGACTTGGGCCTTTCTGACATCATCCT
GAAGAGACAGGACTTTGCGTTTTTCCTCTGGGACCTACAGTGATGAGAATTTAATGATTATCTCCTCCACTATAATCCTCTTTAGGGTGA
TTTTTTAAATCAAAACCCAGTGAATCTCATTACTCCTAAGAAACGAAAGATTCCTTCAAAGCCTTTTCAGGCACATGGTTTCAACAAAGC
CTGGCTTTGACATTCCTTGTCCTGAGGAGCACTTTCCAGGCATAGTTACAGCTTCCCCACTGTATTTACAAGCCAGAATTGTGCAACTCT
TCTGGATCATTAATAAAGTAGCAAGATCCTCAAAAAACCCAAAAACACCATTCTCTAATAGTCATGACAAATGGCTTCAGTATGGCTTGT
TTTTTATTTTCCAGATGGCTTTTTCTCTTATTTTTTGAAGCCCCAGTCTTTGATTTTACAGGTAACTTTCAAAACATCATGATGCTGCCA
AATGTACTTTTGTAAACTTAAACATTATGATTCCTGTATTATTTCAGTGAGAGCTACAGTGTGATATTTCAGAGTCTATTAAATAAAAAT

>9812_9812_1_BLNK-PROSC_BLNK_chr10_98031109_ENST00000224337_PROSC_chr8_37623044_ENST00000328195_length(amino acids)=223AA_BP=
MVIEAYGHGQRTFGENYVQELLEKASNPKILSLCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSVKLADKVNSSWQRKGSPERLKVM
VQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADFQHA

--------------------------------------------------------------
>9812_9812_2_BLNK-PROSC_BLNK_chr10_98031109_ENST00000371176_PROSC_chr8_37623044_ENST00000328195_length(transcript)=2579nt_BP=189nt
GCAGCCTGCACTCTCAGAAATCAGACTTGAGTGGCCGGAACCCTTGAGACCAGAGGCTTACCATGCTGCTCCCTAGGAGGGCCAGGAACT
GCTGACGTGACCACTGGACAGTTATTCGTGTCTCTTACAATTACCAAACAGAATGGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCA
GAAGTTGAGGATCTCCCAGCCATCCAGCCCCGGCTAGTGGCGGTCAGCAAAACCAAACCTGCAGACATGGTGATCGAGGCCTATGGACAT
GGGCAGCGCACTTTTGGCGAGAACTACGTTCAGGAACTGCTAGAAAAAGCATCAAATCCCAAAATTCTGTCTTTGTGTCCTGAGATCAAA
TGGCACTTCATTGGCCACCTACAGAAACAAAATGTCAACAAATTGATGGCTGTCCCCAATCTCTTCATGCTGGAAACAGTGGATTCTGTG
AAGTTGGCAGACAAAGTGAACAGTTCCTGGCAGAGAAAAGGTTCTCCTGAAAGGTTAAAGGTTATGGTCCAGATTAACACCAGCGGAGAA
GAGAGTAAACATGGCCTTCCACCTTCAGAGACCATAGCCATCGTGGAGCACATAAACGCCAAGTGTCCTAACCTGGAGTTTGTGGGGCTG
ATGACCATAGGAAGCTTTGGGCATGATCTTAGTCAAGGACCAAATCCAGACTTCCAGCTGTTATTGTCCCTCCGGGAGGAGCTGTGTAAA
AAGCTGAACATCCCTGCTGACCAGGTTGAGCTGAGCATGGGCATGTCCGCGGATTTCCAGCATGCGGTTGAAGTAGGATCTACAAATGTC
CGAATAGGAAGCACGATTTTTGGAGAGCGGGATTACTCAAAGAAACCCACCCCGGACAAGTGCGCAGCAGACGTGAAGGCCCCGCTGGAG
GTGGCACAGGAGCACTGAGCCAGGGAATACTGAGAGCACTAACTATGCACTAACCTAGATTTTCATTTCGATATTCCCTGTGTCCCAGCG
CAGTCCTGCTCTCCTGTGACCTGTGGAGAGCACTAATGATCACGTGTGTTGATGGAAACCATCTGTGCTTAGTCTCTGACATAGGAAGCT
TGCTTCAGGCAATGGCTTTGGATTGAGTTTGAGAAATTCAAACATTTCTGCAGAACAGATACCAAATCAATAGCTAGGAATCATGTTCAA
TATTGAATTCTGCCCAGGAGCATGAACTGATCCATGAATGCCTTTTCCAGGTTAAAATTTGGTCACTGATGCCTATAATCGTGGAAGTCA
GAGGGATTCCCCTTTTTCATCTCATTTTAATAGGAAAATTCCTTATGGTTAACATCTCCCTACAAACTCCTACTACGTCGTCTAAATTGC
TGCTCTGGAATAAGGTGATTTCTGCCCCCAGATTCTTCCCTAGCCGGTAGATACGTGAAGATATTCCCAACTGTGGAATGGCAGTGTAGG
TAGCTTCAGGAAATGGCTCAGGTTAATTCTCAAAACACAAATTGTTGCTGGCCAGGCATGGTGACTCATGCCTGTAATCCCAGCAATTTG
GGAGACAGAGGCGGAAGGATCACCTGAGCCTAGGAGTTCAAGACCAGCCTCAGCAACAGCAGGAGCCCCACCCCCCGTCTCTACAAAAAA
ATTTAAAAATTAACTGGGCATGGTGGCTGAGGTGGAAGAATGGAAGAATCACTTGAGCCCAGGAGTTTGAGGCTGCAGTGAGCTATGATT
GCACCACTGTACTCCTGCCTTAAAAAAAAAAAAAAAATCCCAATAGTCCATGAAGGCTTTGATCTCTTGGGAAGTTCTTCATAGATGCTG
TCACATTTCTTAAAGCAACCTTTTAATATGCAGATAATACCCCCCAACTTTTTTAGAGACAGCCTGTCTCTTAAAAAAAAAATTAATTTG
GTAGTGAGAGCTTGTGTCACTGCCACTCTGTTTTATCCCTGAAATTAAAGGATAACATAAGGAGGACTTGGGCCTTTCTGACATCATCCT
GAAGAGACAGGACTTTGCGTTTTTCCTCTGGGACCTACAGTGATGAGAATTTAATGATTATCTCCTCCACTATAATCCTCTTTAGGGTGA
TTTTTTAAATCAAAACCCAGTGAATCTCATTACTCCTAAGAAACGAAAGATTCCTTCAAAGCCTTTTCAGGCACATGGTTTCAACAAAGC
CTGGCTTTGACATTCCTTGTCCTGAGGAGCACTTTCCAGGCATAGTTACAGCTTCCCCACTGTATTTACAAGCCAGAATTGTGCAACTCT
TCTGGATCATTAATAAAGTAGCAAGATCCTCAAAAAACCCAAAAACACCATTCTCTAATAGTCATGACAAATGGCTTCAGTATGGCTTGT
TTTTTATTTTCCAGATGGCTTTTTCTCTTATTTTTTGAAGCCCCAGTCTTTGATTTTACAGGTAACTTTCAAAACATCATGATGCTGCCA
AATGTACTTTTGTAAACTTAAACATTATGATTCCTGTATTATTTCAGTGAGAGCTACAGTGTGATATTTCAGAGTCTATTAAATAAAAAT

>9812_9812_2_BLNK-PROSC_BLNK_chr10_98031109_ENST00000371176_PROSC_chr8_37623044_ENST00000328195_length(amino acids)=223AA_BP=
MVIEAYGHGQRTFGENYVQELLEKASNPKILSLCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSVKLADKVNSSWQRKGSPERLKVM
VQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADFQHA

--------------------------------------------------------------
>9812_9812_3_BLNK-PROSC_BLNK_chr10_98031109_ENST00000413476_PROSC_chr8_37623044_ENST00000328195_length(transcript)=2615nt_BP=225nt
AAGTTTTACTTCTCCCTAGAGCAGGGGTGTTTGCCAGCAGCCTGCACTCTCAGAAATCAGACTTGAGTGGCCGGAACCCTTGAGACCAGA
GGCTTACCATGCTGCTCCCTAGGAGGGCCAGGAACTGCTGACGTGACCACTGGACAGTTATTCGTGTCTCTTACAATTACCAAACAGAAT
GGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCAGAAGTTGAGGATCTCCCAGCCATCCAGCCCCGGCTAGTGGCGGTCAGCAAAACC
AAACCTGCAGACATGGTGATCGAGGCCTATGGACATGGGCAGCGCACTTTTGGCGAGAACTACGTTCAGGAACTGCTAGAAAAAGCATCA
AATCCCAAAATTCTGTCTTTGTGTCCTGAGATCAAATGGCACTTCATTGGCCACCTACAGAAACAAAATGTCAACAAATTGATGGCTGTC
CCCAATCTCTTCATGCTGGAAACAGTGGATTCTGTGAAGTTGGCAGACAAAGTGAACAGTTCCTGGCAGAGAAAAGGTTCTCCTGAAAGG
TTAAAGGTTATGGTCCAGATTAACACCAGCGGAGAAGAGAGTAAACATGGCCTTCCACCTTCAGAGACCATAGCCATCGTGGAGCACATA
AACGCCAAGTGTCCTAACCTGGAGTTTGTGGGGCTGATGACCATAGGAAGCTTTGGGCATGATCTTAGTCAAGGACCAAATCCAGACTTC
CAGCTGTTATTGTCCCTCCGGGAGGAGCTGTGTAAAAAGCTGAACATCCCTGCTGACCAGGTTGAGCTGAGCATGGGCATGTCCGCGGAT
TTCCAGCATGCGGTTGAAGTAGGATCTACAAATGTCCGAATAGGAAGCACGATTTTTGGAGAGCGGGATTACTCAAAGAAACCCACCCCG
GACAAGTGCGCAGCAGACGTGAAGGCCCCGCTGGAGGTGGCACAGGAGCACTGAGCCAGGGAATACTGAGAGCACTAACTATGCACTAAC
CTAGATTTTCATTTCGATATTCCCTGTGTCCCAGCGCAGTCCTGCTCTCCTGTGACCTGTGGAGAGCACTAATGATCACGTGTGTTGATG
GAAACCATCTGTGCTTAGTCTCTGACATAGGAAGCTTGCTTCAGGCAATGGCTTTGGATTGAGTTTGAGAAATTCAAACATTTCTGCAGA
ACAGATACCAAATCAATAGCTAGGAATCATGTTCAATATTGAATTCTGCCCAGGAGCATGAACTGATCCATGAATGCCTTTTCCAGGTTA
AAATTTGGTCACTGATGCCTATAATCGTGGAAGTCAGAGGGATTCCCCTTTTTCATCTCATTTTAATAGGAAAATTCCTTATGGTTAACA
TCTCCCTACAAACTCCTACTACGTCGTCTAAATTGCTGCTCTGGAATAAGGTGATTTCTGCCCCCAGATTCTTCCCTAGCCGGTAGATAC
GTGAAGATATTCCCAACTGTGGAATGGCAGTGTAGGTAGCTTCAGGAAATGGCTCAGGTTAATTCTCAAAACACAAATTGTTGCTGGCCA
GGCATGGTGACTCATGCCTGTAATCCCAGCAATTTGGGAGACAGAGGCGGAAGGATCACCTGAGCCTAGGAGTTCAAGACCAGCCTCAGC
AACAGCAGGAGCCCCACCCCCCGTCTCTACAAAAAAATTTAAAAATTAACTGGGCATGGTGGCTGAGGTGGAAGAATGGAAGAATCACTT
GAGCCCAGGAGTTTGAGGCTGCAGTGAGCTATGATTGCACCACTGTACTCCTGCCTTAAAAAAAAAAAAAAAATCCCAATAGTCCATGAA
GGCTTTGATCTCTTGGGAAGTTCTTCATAGATGCTGTCACATTTCTTAAAGCAACCTTTTAATATGCAGATAATACCCCCCAACTTTTTT
AGAGACAGCCTGTCTCTTAAAAAAAAAATTAATTTGGTAGTGAGAGCTTGTGTCACTGCCACTCTGTTTTATCCCTGAAATTAAAGGATA
ACATAAGGAGGACTTGGGCCTTTCTGACATCATCCTGAAGAGACAGGACTTTGCGTTTTTCCTCTGGGACCTACAGTGATGAGAATTTAA
TGATTATCTCCTCCACTATAATCCTCTTTAGGGTGATTTTTTAAATCAAAACCCAGTGAATCTCATTACTCCTAAGAAACGAAAGATTCC
TTCAAAGCCTTTTCAGGCACATGGTTTCAACAAAGCCTGGCTTTGACATTCCTTGTCCTGAGGAGCACTTTCCAGGCATAGTTACAGCTT
CCCCACTGTATTTACAAGCCAGAATTGTGCAACTCTTCTGGATCATTAATAAAGTAGCAAGATCCTCAAAAAACCCAAAAACACCATTCT
CTAATAGTCATGACAAATGGCTTCAGTATGGCTTGTTTTTTATTTTCCAGATGGCTTTTTCTCTTATTTTTTGAAGCCCCAGTCTTTGAT
TTTACAGGTAACTTTCAAAACATCATGATGCTGCCAAATGTACTTTTGTAAACTTAAACATTATGATTCCTGTATTATTTCAGTGAGAGC
TACAGTGTGATATTTCAGAGTCTATTAAATAAAAATGTGAGTTTGAATTACACCATCTGTGCCAATTACAAAGCAATTAAAAGATTTATT

>9812_9812_3_BLNK-PROSC_BLNK_chr10_98031109_ENST00000413476_PROSC_chr8_37623044_ENST00000328195_length(amino acids)=223AA_BP=
MVIEAYGHGQRTFGENYVQELLEKASNPKILSLCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSVKLADKVNSSWQRKGSPERLKVM
VQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADFQHA

--------------------------------------------------------------
>9812_9812_4_BLNK-PROSC_BLNK_chr10_98031109_ENST00000427367_PROSC_chr8_37623044_ENST00000328195_length(transcript)=2615nt_BP=225nt
AAGTTTTACTTCTCCCTAGAGCAGGGGTGTTTGCCAGCAGCCTGCACTCTCAGAAATCAGACTTGAGTGGCCGGAACCCTTGAGACCAGA
GGCTTACCATGCTGCTCCCTAGGAGGGCCAGGAACTGCTGACGTGACCACTGGACAGTTATTCGTGTCTCTTACAATTACCAAACAGAAT
GGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCAGAAGTTGAGGATCTCCCAGCCATCCAGCCCCGGCTAGTGGCGGTCAGCAAAACC
AAACCTGCAGACATGGTGATCGAGGCCTATGGACATGGGCAGCGCACTTTTGGCGAGAACTACGTTCAGGAACTGCTAGAAAAAGCATCA
AATCCCAAAATTCTGTCTTTGTGTCCTGAGATCAAATGGCACTTCATTGGCCACCTACAGAAACAAAATGTCAACAAATTGATGGCTGTC
CCCAATCTCTTCATGCTGGAAACAGTGGATTCTGTGAAGTTGGCAGACAAAGTGAACAGTTCCTGGCAGAGAAAAGGTTCTCCTGAAAGG
TTAAAGGTTATGGTCCAGATTAACACCAGCGGAGAAGAGAGTAAACATGGCCTTCCACCTTCAGAGACCATAGCCATCGTGGAGCACATA
AACGCCAAGTGTCCTAACCTGGAGTTTGTGGGGCTGATGACCATAGGAAGCTTTGGGCATGATCTTAGTCAAGGACCAAATCCAGACTTC
CAGCTGTTATTGTCCCTCCGGGAGGAGCTGTGTAAAAAGCTGAACATCCCTGCTGACCAGGTTGAGCTGAGCATGGGCATGTCCGCGGAT
TTCCAGCATGCGGTTGAAGTAGGATCTACAAATGTCCGAATAGGAAGCACGATTTTTGGAGAGCGGGATTACTCAAAGAAACCCACCCCG
GACAAGTGCGCAGCAGACGTGAAGGCCCCGCTGGAGGTGGCACAGGAGCACTGAGCCAGGGAATACTGAGAGCACTAACTATGCACTAAC
CTAGATTTTCATTTCGATATTCCCTGTGTCCCAGCGCAGTCCTGCTCTCCTGTGACCTGTGGAGAGCACTAATGATCACGTGTGTTGATG
GAAACCATCTGTGCTTAGTCTCTGACATAGGAAGCTTGCTTCAGGCAATGGCTTTGGATTGAGTTTGAGAAATTCAAACATTTCTGCAGA
ACAGATACCAAATCAATAGCTAGGAATCATGTTCAATATTGAATTCTGCCCAGGAGCATGAACTGATCCATGAATGCCTTTTCCAGGTTA
AAATTTGGTCACTGATGCCTATAATCGTGGAAGTCAGAGGGATTCCCCTTTTTCATCTCATTTTAATAGGAAAATTCCTTATGGTTAACA
TCTCCCTACAAACTCCTACTACGTCGTCTAAATTGCTGCTCTGGAATAAGGTGATTTCTGCCCCCAGATTCTTCCCTAGCCGGTAGATAC
GTGAAGATATTCCCAACTGTGGAATGGCAGTGTAGGTAGCTTCAGGAAATGGCTCAGGTTAATTCTCAAAACACAAATTGTTGCTGGCCA
GGCATGGTGACTCATGCCTGTAATCCCAGCAATTTGGGAGACAGAGGCGGAAGGATCACCTGAGCCTAGGAGTTCAAGACCAGCCTCAGC
AACAGCAGGAGCCCCACCCCCCGTCTCTACAAAAAAATTTAAAAATTAACTGGGCATGGTGGCTGAGGTGGAAGAATGGAAGAATCACTT
GAGCCCAGGAGTTTGAGGCTGCAGTGAGCTATGATTGCACCACTGTACTCCTGCCTTAAAAAAAAAAAAAAAATCCCAATAGTCCATGAA
GGCTTTGATCTCTTGGGAAGTTCTTCATAGATGCTGTCACATTTCTTAAAGCAACCTTTTAATATGCAGATAATACCCCCCAACTTTTTT
AGAGACAGCCTGTCTCTTAAAAAAAAAATTAATTTGGTAGTGAGAGCTTGTGTCACTGCCACTCTGTTTTATCCCTGAAATTAAAGGATA
ACATAAGGAGGACTTGGGCCTTTCTGACATCATCCTGAAGAGACAGGACTTTGCGTTTTTCCTCTGGGACCTACAGTGATGAGAATTTAA
TGATTATCTCCTCCACTATAATCCTCTTTAGGGTGATTTTTTAAATCAAAACCCAGTGAATCTCATTACTCCTAAGAAACGAAAGATTCC
TTCAAAGCCTTTTCAGGCACATGGTTTCAACAAAGCCTGGCTTTGACATTCCTTGTCCTGAGGAGCACTTTCCAGGCATAGTTACAGCTT
CCCCACTGTATTTACAAGCCAGAATTGTGCAACTCTTCTGGATCATTAATAAAGTAGCAAGATCCTCAAAAAACCCAAAAACACCATTCT
CTAATAGTCATGACAAATGGCTTCAGTATGGCTTGTTTTTTATTTTCCAGATGGCTTTTTCTCTTATTTTTTGAAGCCCCAGTCTTTGAT
TTTACAGGTAACTTTCAAAACATCATGATGCTGCCAAATGTACTTTTGTAAACTTAAACATTATGATTCCTGTATTATTTCAGTGAGAGC
TACAGTGTGATATTTCAGAGTCTATTAAATAAAAATGTGAGTTTGAATTACACCATCTGTGCCAATTACAAAGCAATTAAAAGATTTATT

>9812_9812_4_BLNK-PROSC_BLNK_chr10_98031109_ENST00000427367_PROSC_chr8_37623044_ENST00000328195_length(amino acids)=223AA_BP=
MVIEAYGHGQRTFGENYVQELLEKASNPKILSLCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSVKLADKVNSSWQRKGSPERLKVM
VQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADFQHA

--------------------------------------------------------------
>9812_9812_5_BLNK-PROSC_BLNK_chr10_98031109_ENST00000495266_PROSC_chr8_37623044_ENST00000328195_length(transcript)=2437nt_BP=47nt
ATGGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCAGAAGTTGAGGATCTCCCAGCCATCCAGCCCCGGCTAGTGGCGGTCAGCAAAA
CCAAACCTGCAGACATGGTGATCGAGGCCTATGGACATGGGCAGCGCACTTTTGGCGAGAACTACGTTCAGGAACTGCTAGAAAAAGCAT
CAAATCCCAAAATTCTGTCTTTGTGTCCTGAGATCAAATGGCACTTCATTGGCCACCTACAGAAACAAAATGTCAACAAATTGATGGCTG
TCCCCAATCTCTTCATGCTGGAAACAGTGGATTCTGTGAAGTTGGCAGACAAAGTGAACAGTTCCTGGCAGAGAAAAGGTTCTCCTGAAA
GGTTAAAGGTTATGGTCCAGATTAACACCAGCGGAGAAGAGAGTAAACATGGCCTTCCACCTTCAGAGACCATAGCCATCGTGGAGCACA
TAAACGCCAAGTGTCCTAACCTGGAGTTTGTGGGGCTGATGACCATAGGAAGCTTTGGGCATGATCTTAGTCAAGGACCAAATCCAGACT
TCCAGCTGTTATTGTCCCTCCGGGAGGAGCTGTGTAAAAAGCTGAACATCCCTGCTGACCAGGTTGAGCTGAGCATGGGCATGTCCGCGG
ATTTCCAGCATGCGGTTGAAGTAGGATCTACAAATGTCCGAATAGGAAGCACGATTTTTGGAGAGCGGGATTACTCAAAGAAACCCACCC
CGGACAAGTGCGCAGCAGACGTGAAGGCCCCGCTGGAGGTGGCACAGGAGCACTGAGCCAGGGAATACTGAGAGCACTAACTATGCACTA
ACCTAGATTTTCATTTCGATATTCCCTGTGTCCCAGCGCAGTCCTGCTCTCCTGTGACCTGTGGAGAGCACTAATGATCACGTGTGTTGA
TGGAAACCATCTGTGCTTAGTCTCTGACATAGGAAGCTTGCTTCAGGCAATGGCTTTGGATTGAGTTTGAGAAATTCAAACATTTCTGCA
GAACAGATACCAAATCAATAGCTAGGAATCATGTTCAATATTGAATTCTGCCCAGGAGCATGAACTGATCCATGAATGCCTTTTCCAGGT
TAAAATTTGGTCACTGATGCCTATAATCGTGGAAGTCAGAGGGATTCCCCTTTTTCATCTCATTTTAATAGGAAAATTCCTTATGGTTAA
CATCTCCCTACAAACTCCTACTACGTCGTCTAAATTGCTGCTCTGGAATAAGGTGATTTCTGCCCCCAGATTCTTCCCTAGCCGGTAGAT
ACGTGAAGATATTCCCAACTGTGGAATGGCAGTGTAGGTAGCTTCAGGAAATGGCTCAGGTTAATTCTCAAAACACAAATTGTTGCTGGC
CAGGCATGGTGACTCATGCCTGTAATCCCAGCAATTTGGGAGACAGAGGCGGAAGGATCACCTGAGCCTAGGAGTTCAAGACCAGCCTCA
GCAACAGCAGGAGCCCCACCCCCCGTCTCTACAAAAAAATTTAAAAATTAACTGGGCATGGTGGCTGAGGTGGAAGAATGGAAGAATCAC
TTGAGCCCAGGAGTTTGAGGCTGCAGTGAGCTATGATTGCACCACTGTACTCCTGCCTTAAAAAAAAAAAAAAAATCCCAATAGTCCATG
AAGGCTTTGATCTCTTGGGAAGTTCTTCATAGATGCTGTCACATTTCTTAAAGCAACCTTTTAATATGCAGATAATACCCCCCAACTTTT
TTAGAGACAGCCTGTCTCTTAAAAAAAAAATTAATTTGGTAGTGAGAGCTTGTGTCACTGCCACTCTGTTTTATCCCTGAAATTAAAGGA
TAACATAAGGAGGACTTGGGCCTTTCTGACATCATCCTGAAGAGACAGGACTTTGCGTTTTTCCTCTGGGACCTACAGTGATGAGAATTT
AATGATTATCTCCTCCACTATAATCCTCTTTAGGGTGATTTTTTAAATCAAAACCCAGTGAATCTCATTACTCCTAAGAAACGAAAGATT
CCTTCAAAGCCTTTTCAGGCACATGGTTTCAACAAAGCCTGGCTTTGACATTCCTTGTCCTGAGGAGCACTTTCCAGGCATAGTTACAGC
TTCCCCACTGTATTTACAAGCCAGAATTGTGCAACTCTTCTGGATCATTAATAAAGTAGCAAGATCCTCAAAAAACCCAAAAACACCATT
CTCTAATAGTCATGACAAATGGCTTCAGTATGGCTTGTTTTTTATTTTCCAGATGGCTTTTTCTCTTATTTTTTGAAGCCCCAGTCTTTG
ATTTTACAGGTAACTTTCAAAACATCATGATGCTGCCAAATGTACTTTTGTAAACTTAAACATTATGATTCCTGTATTATTTCAGTGAGA
GCTACAGTGTGATATTTCAGAGTCTATTAAATAAAAATGTGAGTTTGAATTACACCATCTGTGCCAATTACAAAGCAATTAAAAGATTTA

>9812_9812_5_BLNK-PROSC_BLNK_chr10_98031109_ENST00000495266_PROSC_chr8_37623044_ENST00000328195_length(amino acids)=223AA_BP=
MVIEAYGHGQRTFGENYVQELLEKASNPKILSLCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSVKLADKVNSSWQRKGSPERLKVM
VQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADFQHA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BLNK-PROSC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BLNK-PROSC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BLNK-PROSC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBLNKC0001768Agammaglobulinemia1CTD_human;GENOMICS_ENGLAND
HgeneBLNKC1832241Agammaglobulinemia, non-Bruton type1ORPHANET
HgeneBLNKC3150752AGAMMAGLOBULINEMIA 4, AUTOSOMAL RECESSIVE1GENOMICS_ENGLAND