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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:BLNK-PIK3AP1 (FusionGDB2 ID:HG29760TG118788)

Fusion Gene Summary for BLNK-PIK3AP1

check button Fusion gene summary
Fusion gene informationFusion gene name: BLNK-PIK3AP1
Fusion gene ID: hg29760tg118788
HgeneTgene
Gene symbol

BLNK

PIK3AP1

Gene ID

29760

118788

Gene nameB cell linkerphosphoinositide-3-kinase adaptor protein 1
SynonymsAGM4|BASH|BLNK-S|LY57|SLP-65|SLP65|bcaBCAP
Cytomap('BLNK')('PIK3AP1')

10q24.1

10q24.1

Type of geneprotein-codingprotein-coding
DescriptionB-cell linker proteinB cell adaptor containing SH2 domainB-cell activationB-cell adapter containing a SH2 domain proteinB-cell adapter containing a Src homology 2 domain proteinSrc homology 2 domain-containing leukocyte protein of 65 kDaSrc homologyphosphoinositide 3-kinase adapter protein 1B cell adaptor proteinB-cell adapter for phosphoinositide 3-kinaseB-cell phosphoinositide 3-kinase adapter protein 1
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000224337, ENST00000371176, 
ENST00000413476, ENST00000427367, 
ENST00000495266, 
Fusion gene scores* DoF score7 X 6 X 6=2527 X 6 X 4=168
# samples 78
** MAII scorelog2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BLNK [Title/Abstract] AND PIK3AP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBLNK(97976409)-PIK3AP1(98388250), # samples:3
Anticipated loss of major functional domain due to fusion event.BLNK-PIK3AP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BLNK-PIK3AP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BLNK-PIK3AP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BLNK-PIK3AP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BLNK-PIK3AP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BLNK-PIK3AP1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
BLNK-PIK3AP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBLNK

GO:0035556

intracellular signal transduction

9341187


check buttonFusion gene breakpoints across BLNK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PIK3AP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-S3-A6ZF-01ABLNKchr10

97969594

-PIK3AP1chr10

98388250

-
ChimerDB4BRCATCGA-S3-A6ZF-01ABLNKchr10

97976409

-PIK3AP1chr10

98388250

-


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Fusion Gene ORF analysis for BLNK-PIK3AP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000224337ENST00000371109BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000224337ENST00000371109BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000224337ENST00000371110BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000224337ENST00000371110BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000224337ENST00000468783BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000224337ENST00000468783BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000371176ENST00000371109BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000371176ENST00000371109BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000371176ENST00000371110BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000371176ENST00000371110BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000371176ENST00000468783BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000371176ENST00000468783BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000413476ENST00000371109BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000413476ENST00000371109BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000413476ENST00000371110BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000413476ENST00000371110BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000413476ENST00000468783BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000413476ENST00000468783BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000427367ENST00000371109BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000427367ENST00000371109BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000427367ENST00000371110BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000427367ENST00000371110BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000427367ENST00000468783BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
5CDS-5UTRENST00000427367ENST00000468783BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
Frame-shiftENST00000224337ENST00000339364BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
Frame-shiftENST00000371176ENST00000339364BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
Frame-shiftENST00000413476ENST00000339364BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
Frame-shiftENST00000427367ENST00000339364BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
In-frameENST00000224337ENST00000339364BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
In-frameENST00000371176ENST00000339364BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
In-frameENST00000413476ENST00000339364BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
In-frameENST00000427367ENST00000339364BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
intron-3CDSENST00000495266ENST00000339364BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
intron-3CDSENST00000495266ENST00000339364BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
intron-5UTRENST00000495266ENST00000371109BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
intron-5UTRENST00000495266ENST00000371109BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
intron-5UTRENST00000495266ENST00000371110BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
intron-5UTRENST00000495266ENST00000371110BLNKchr10

97976409

-PIK3AP1chr10

98388250

-
intron-5UTRENST00000495266ENST00000468783BLNKchr10

97969594

-PIK3AP1chr10

98388250

-
intron-5UTRENST00000495266ENST00000468783BLNKchr10

97976409

-PIK3AP1chr10

98388250

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000224337BLNKchr1097976409-ENST00000339364PIK3AP1chr1098388250-40577491031791562
ENST00000371176BLNKchr1097976409-ENST00000339364PIK3AP1chr1098388250-40577491031791562
ENST00000427367BLNKchr1097976409-ENST00000339364PIK3AP1chr1098388250-40937851391827562
ENST00000413476BLNKchr1097976409-ENST00000339364PIK3AP1chr1098388250-40937851391827562

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000224337ENST00000339364BLNKchr1097976409-PIK3AP1chr1098388250-0.0003646770.99963534
ENST00000371176ENST00000339364BLNKchr1097976409-PIK3AP1chr1098388250-0.0003646770.99963534
ENST00000427367ENST00000339364BLNKchr1097976409-PIK3AP1chr1098388250-0.0003720330.99962795
ENST00000413476ENST00000339364BLNKchr1097976409-PIK3AP1chr1098388250-0.0003720330.99962795

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Fusion Genomic Features for BLNK-PIK3AP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BLNK-PIK3AP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:97976409/chr10:98388250)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePIK3AP1chr10:97976409chr10:98388250ENST00000339364717645_667458806.0Coiled coilOntology_term=ECO:0000255
TgenePIK3AP1chr10:97976409chr10:98388250ENST00000371109010645_66757405.0Coiled coilOntology_term=ECO:0000255
TgenePIK3AP1chr10:97976409chr10:98388250ENST00000371110616645_667280628.0Coiled coilOntology_term=ECO:0000255
TgenePIK3AP1chr10:97976409chr10:98388250ENST00000339364717760_802458806.0Compositional biasNote=Pro-rich
TgenePIK3AP1chr10:97976409chr10:98388250ENST00000371109010760_80257405.0Compositional biasNote=Pro-rich
TgenePIK3AP1chr10:97976409chr10:98388250ENST00000371110616760_802280628.0Compositional biasNote=Pro-rich
TgenePIK3AP1chr10:97976409chr10:98388250ENST00000371109010181_31757405.0DomainDBB

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBLNKchr10:97976409chr10:98388250ENST00000224337-71798_260202457.0Compositional biasNote=Pro-rich
HgeneBLNKchr10:97976409chr10:98388250ENST00000371176-71698_260202434.0Compositional biasNote=Pro-rich
HgeneBLNKchr10:97976409chr10:98388250ENST00000413476-71698_260202405.0Compositional biasNote=Pro-rich
HgeneBLNKchr10:97976409chr10:98388250ENST00000224337-717346_453202457.0DomainSH2
HgeneBLNKchr10:97976409chr10:98388250ENST00000371176-716346_453202434.0DomainSH2
HgeneBLNKchr10:97976409chr10:98388250ENST00000413476-716346_453202405.0DomainSH2
TgenePIK3AP1chr10:97976409chr10:98388250ENST00000339364717181_317458806.0DomainDBB
TgenePIK3AP1chr10:97976409chr10:98388250ENST000003393647178_145458806.0DomainTIR
TgenePIK3AP1chr10:97976409chr10:98388250ENST000003711090108_14557405.0DomainTIR
TgenePIK3AP1chr10:97976409chr10:98388250ENST00000371110616181_317280628.0DomainDBB
TgenePIK3AP1chr10:97976409chr10:98388250ENST000003711106168_145280628.0DomainTIR


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Fusion Gene Sequence for BLNK-PIK3AP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9811_9811_1_BLNK-PIK3AP1_BLNK_chr10_97976409_ENST00000224337_PIK3AP1_chr10_98388250_ENST00000339364_length(transcript)=4057nt_BP=749nt
GCAGCCTGCACTCTCAGAAATCAGACTTGAGTGGCCGGAACCCTTGAGACCAGAGGCTTACCATGCTGCTCCCTAGGAGGGCCAGGAACT
GCTGACGTGACCACTGGACAGTTATTCGTGTCTCTTACAATTACCAAACAGAATGGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCA
GAAGTTGAGGCAGCTTCAAAAGATGGTCCATGATATTAAAAACAATGAAGGTGGAATAATGAATAAAATCAAAAAGCTAAAAGTCAAAGC
ACCTCCAAGTGTTCCTCGAAGGGACTACGCTTCAGAGAGCCCTGCTGACGAAGAGGAGCAGTGGTCCGATGACTTTGACAGCGACTATGA
AAATCCAGATGAGCACTCGGACTCAGAGATGTACGTGATGCCCGCCGAGGAGAACGCTGATGACAGCTACGAGCCGCCTCCAGTAGAGCA
GGAAACCAGGCCGGTTCACCCAGCCCTGCCCTTCGCCAGAGGCGAGTATATAGACAATCGATCAAGCCAGAGGCATTCCCCACCCTTCAG
CAAGACACTTCCCAGTAAGCCCAGCTGGCCTTCAGAGAAAGCAAGGCTCACCTCCACCCTGCCGGCCCTGACTGCTTTGCAGAAACCTCA
AGTCCCACCCAAACCCAAAGGCCTCCTTGAGGATGAGGCTGATTATGTGGTCCCCGTGGAAGATAATGATGAAAACTATATTCATCCCAC
AGAAAGCAGTTCACCTCCACCTGAAAAAGATGTTGAAATGCTTCAGGCCAGTACATCTAACCCAATCCCTGGAGATGGTTTCTCTCGGGC
CACTAAGGACTCTATGATCCGCAAGTTTTTAGAAGGCAACAGCATGGGAATGACCAATCTGGAGAGAGATCAGTGCCATCTTGGTCAGGA
AGAAGATGTTTATCACACGGTGGATGACGATGAGGCCTTTTCTGTGGACCTGGCCAGCAGGCCCCCTGTCCCAGTGCCCAGACCAGAGAC
CACTGCTCCTGGTGCTCACCAGCTGCCTGACAACGAACCATACATTTTTAAAGTTTTTGCAGAAAAAAGTCAAGAGCGGCCTGGGAATTT
CTACGTTTCCTCAGAGAGCATCAGGAAAGGGCCGCCCGTCAGACCATGGAGGGACAGGCCCCAGTCGAGTATATATGACCCTTTTGCGGG
AATGAAAACGCCAGGCCAGCGGCAGCTTATCACCCTCCAGGAGCAGGTGAAGCTGGGCATTGTCAACGTGGATGAGGCTGTGCTCCACTT
CAAAGAGTGGCAGCTCAACCAGAAGAAACGATCGGAGTCCTTTCGTTTCCAGCAGGAAAATCTTAAACGGCTAAGAGACAGCATCACCCG
AAGACAGAGAGAGAAGCAAAAATCAGGAAAGCAGACAGACTTGGAGATCACGGTCCCAATTCGGCACTCACAGCACCTGCCTGCAAAAGT
GGAGTTTGGAGTCTATGAGAGTGGCCCCAGGAAAAGTGTCATTCCCCCTAGGACGGAGCTGAGACGAGGAGACTGGAAAACAGACAGCAC
CTCCAGCACAGCAAGTAGCACAAGTAACCGCTCCAGCACCCGGAGCCTCCTCAGTGTGAGCAGCGGGATGGAAGGGGACAACGAGGATAA
TGAAGTCCCTGAGGTTACCAGAAGTCGCAGTCCAGGCCCCCCACAAGTGGATGGGACACCCACCATGTCCCTCGAGAGACCCCCCAGGGT
GCCTCCGAGAGCTGCCTCACAGAGGCCTCCGACCAGGGAGACCTTCCATCCTCCTCCACCTGTTCCACCCAGAGGACGCTGATTCCACCT
CCTAAAACCTGCCTACTTCAGGACTTTAAGACTCACAGTCTTCAGCCTGTTAATGATGTCTTCATGTTGAGTTTTATAGCATGACTGTTG
ACCTTAAGATCCATTCTCATTGCTGATAATGCTGCAGCCCTGCTGGTTTGGGCTTGCCTCGAAGATTTTATTAAGGCACGAAGAAGTGAA
AAACTAAGGGCTTCATTCACCATCACCAAGTATATCGAACCATATACTTGTTTGCCAAAAGGATGAAGACTTAATCGAAATACTTACCTC
TAATTTGCCATATCAGAAGCCTAAAAAGAATGATCATAAATGTACTTCACCAGTGATTTTACTGAAATGCACTTATATTAGTCTTTATGT
ATTTGCTAGTTCAGCCTGATTTCTAGAAGAGGTTATAGTGTGAGACTTGTAGTATTCAAGTAAGATAAGTGACCTAATTTTAAAATAATT
CTTCTACTTTTCTGTATATTCAGCAGGGTATTTAAGTGCTAGGGCTGGTCACACACAACCAACTGAAAAAGACTAGAGGGATTAGTACAA
ACTCCTCTTATACAGAAGGCAAATCTGAGGTTCCACAGAAGTCTGGAACCAAGACTATTCAGTTGGTTAAATAAAGAGGTTAGTCTAGAC
TGGGCCTGCTCATTCTAGGTCACCACATTTTCCATCTCCAAATAGCCAGGCCCTCTCTCCCTCAAGAAATGCCCAGATGTAGAAATTCAT
CAGTGCCTATTGGTCTTCCAGAATTTTCCATCTTCCGTATCTCCCAGGCATGAGACTACCAAGTTTGTTTGTTTTCTTTCCAATTTGGGA
ATTTATACTTCAGTATGGTTTCAACGCAGTTATGTTTCCAGAGAACATCTAGAAGTGGCTGGAAACCAGAAGCTGGGGATTCCAGGGACC
CCACTTAGTGCTCTATTTCCTTTATAGGTTTTATTTCTGGTCATAGAGAGAGAAGGACCTTTGACTTTTTCTTCGTTGAGGCTTCTGAGG
AGGAAAAACAAACCTAAAATAGAAATACAGTCAGCCTTTCAAATCCATGGGTTCTGTGTCCGTGGATTCAACCAACCTTGGATCAAAAAT
ATTTGAAAAAAAATCTACAAAGTTTCAAAAAGCAAAACTTGAATTTGCTGCATGCCAAGAAGTATGTTGAATTCATGTAAATGAAGTGAT
GTGTAGGCATTGTATTAGATATTATAAGAAATCTAGAAATGATTTAAAGCATACAGGAGGATGTGCATAGGTTATATGCAAATACTATGC
TATTTTATATATGGGACTTGAGCATTTGTGGATTTTGATACTGGGGGATCCTGGAACCAATCCCCCATGGATACCAAAGTACGACTGTAG
TTATCTATTTTTTACATACTTATTATTACCACCATGCTCAGTAAGTCCATTTTTGCATGGAATATGGAGCCTTAAAACATGTCATGAATT
TGGAGTCCCTGGCACATAAATCTACCTTCAAATCAGAGGTCCTTAATGATGCCTAAACATACAGTAAAATTAGAATCAGAAATACTTCTT
TAAAAAATATTCAAAATGTGTTTGTTTCCCATGGGATTATTCTCTATCCCACACGAATGTAAAAAAATCCACATTAATGATCCATTTAAG
TATAGTTTTATTGGGTCCTTTTCTAATGATTAAAGGTTCTTTCTCAATTTCATTCCTCAGTCCTGCAAGTAAGGACTCATACTGAAGAGT
ACTGAAACAAGGACTTCTTGTCAGAAACAGCTTCTGGAATCTTGGGTTTTGTTTTTGTTTTTTGACAAAATACACTATTGGCCATGTCCA
TCACGAGAGTGTTTGTAGTAATTAATTACCTTGTACAGGACCTGGCACTTAGTAGCATTCTTCAAATGTTCCCTCAGTGATCCTTTTACT
CTCCTTGTCACTTATTTGGGAGAAATAGGGGCACGTGAGATAAGAAGAAGAATAATTTTGATGTTGGTATGCTTGCCCTGTTACTTATAG
ACAGTCTTTGTCATAGGCAAACTTGAATTTGATTTAAAATAGGGCTGGGAAAAATATTCAATAACTGTAAGCCCCCTTTTGGATGCCAAA
CTTAGAATTTTGTACATTCTCTGATGAACAAGCATTTAGATCGTAACATGGTAAAGCCTATTACCAGCCAATGTTGTTAGCATCTTTGTA
TGCACATCACTGTTTGTGCAATATATGAATATTTTGTTGCATTGTATTCTTATATAAAAATAAGTAGAAAACATAAAATTGAAATTGCTG

>9811_9811_1_BLNK-PIK3AP1_BLNK_chr10_97976409_ENST00000224337_PIK3AP1_chr10_98388250_ENST00000339364_length(amino acids)=562AA_BP=215
MDSYSCLLQLPNRMDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASESPADEEEQWSDDFDSDYENPDE
HSDSEMYVMPAEENADDSYEPPPVEQETRPVHPALPFARGEYIDNRSSQRHSPPFSKTLPSKPSWPSEKARLTSTLPALTALQKPQVPPK
PKGLLEDEADYVVPVEDNDENYIHPTESSSPPPEKDVEMLQASTSNPIPGDGFSRATKDSMIRKFLEGNSMGMTNLERDQCHLGQEEDVY
HTVDDDEAFSVDLASRPPVPVPRPETTAPGAHQLPDNEPYIFKVFAEKSQERPGNFYVSSESIRKGPPVRPWRDRPQSSIYDPFAGMKTP
GQRQLITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQREKQKSGKQTDLEITVPIRHSQHLPAKVEFGV
YESGPRKSVIPPRTELRRGDWKTDSTSSTASSTSNRSSTRSLLSVSSGMEGDNEDNEVPEVTRSRSPGPPQVDGTPTMSLERPPRVPPRA

--------------------------------------------------------------
>9811_9811_2_BLNK-PIK3AP1_BLNK_chr10_97976409_ENST00000371176_PIK3AP1_chr10_98388250_ENST00000339364_length(transcript)=4057nt_BP=749nt
GCAGCCTGCACTCTCAGAAATCAGACTTGAGTGGCCGGAACCCTTGAGACCAGAGGCTTACCATGCTGCTCCCTAGGAGGGCCAGGAACT
GCTGACGTGACCACTGGACAGTTATTCGTGTCTCTTACAATTACCAAACAGAATGGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCA
GAAGTTGAGGCAGCTTCAAAAGATGGTCCATGATATTAAAAACAATGAAGGTGGAATAATGAATAAAATCAAAAAGCTAAAAGTCAAAGC
ACCTCCAAGTGTTCCTCGAAGGGACTACGCTTCAGAGAGCCCTGCTGACGAAGAGGAGCAGTGGTCCGATGACTTTGACAGCGACTATGA
AAATCCAGATGAGCACTCGGACTCAGAGATGTACGTGATGCCCGCCGAGGAGAACGCTGATGACAGCTACGAGCCGCCTCCAGTAGAGCA
GGAAACCAGGCCGGTTCACCCAGCCCTGCCCTTCGCCAGAGGCGAGTATATAGACAATCGATCAAGCCAGAGGCATTCCCCACCCTTCAG
CAAGACACTTCCCAGTAAGCCCAGCTGGCCTTCAGAGAAAGCAAGGCTCACCTCCACCCTGCCGGCCCTGACTGCTTTGCAGAAACCTCA
AGTCCCACCCAAACCCAAAGGCCTCCTTGAGGATGAGGCTGATTATGTGGTCCCCGTGGAAGATAATGATGAAAACTATATTCATCCCAC
AGAAAGCAGTTCACCTCCACCTGAAAAAGATGTTGAAATGCTTCAGGCCAGTACATCTAACCCAATCCCTGGAGATGGTTTCTCTCGGGC
CACTAAGGACTCTATGATCCGCAAGTTTTTAGAAGGCAACAGCATGGGAATGACCAATCTGGAGAGAGATCAGTGCCATCTTGGTCAGGA
AGAAGATGTTTATCACACGGTGGATGACGATGAGGCCTTTTCTGTGGACCTGGCCAGCAGGCCCCCTGTCCCAGTGCCCAGACCAGAGAC
CACTGCTCCTGGTGCTCACCAGCTGCCTGACAACGAACCATACATTTTTAAAGTTTTTGCAGAAAAAAGTCAAGAGCGGCCTGGGAATTT
CTACGTTTCCTCAGAGAGCATCAGGAAAGGGCCGCCCGTCAGACCATGGAGGGACAGGCCCCAGTCGAGTATATATGACCCTTTTGCGGG
AATGAAAACGCCAGGCCAGCGGCAGCTTATCACCCTCCAGGAGCAGGTGAAGCTGGGCATTGTCAACGTGGATGAGGCTGTGCTCCACTT
CAAAGAGTGGCAGCTCAACCAGAAGAAACGATCGGAGTCCTTTCGTTTCCAGCAGGAAAATCTTAAACGGCTAAGAGACAGCATCACCCG
AAGACAGAGAGAGAAGCAAAAATCAGGAAAGCAGACAGACTTGGAGATCACGGTCCCAATTCGGCACTCACAGCACCTGCCTGCAAAAGT
GGAGTTTGGAGTCTATGAGAGTGGCCCCAGGAAAAGTGTCATTCCCCCTAGGACGGAGCTGAGACGAGGAGACTGGAAAACAGACAGCAC
CTCCAGCACAGCAAGTAGCACAAGTAACCGCTCCAGCACCCGGAGCCTCCTCAGTGTGAGCAGCGGGATGGAAGGGGACAACGAGGATAA
TGAAGTCCCTGAGGTTACCAGAAGTCGCAGTCCAGGCCCCCCACAAGTGGATGGGACACCCACCATGTCCCTCGAGAGACCCCCCAGGGT
GCCTCCGAGAGCTGCCTCACAGAGGCCTCCGACCAGGGAGACCTTCCATCCTCCTCCACCTGTTCCACCCAGAGGACGCTGATTCCACCT
CCTAAAACCTGCCTACTTCAGGACTTTAAGACTCACAGTCTTCAGCCTGTTAATGATGTCTTCATGTTGAGTTTTATAGCATGACTGTTG
ACCTTAAGATCCATTCTCATTGCTGATAATGCTGCAGCCCTGCTGGTTTGGGCTTGCCTCGAAGATTTTATTAAGGCACGAAGAAGTGAA
AAACTAAGGGCTTCATTCACCATCACCAAGTATATCGAACCATATACTTGTTTGCCAAAAGGATGAAGACTTAATCGAAATACTTACCTC
TAATTTGCCATATCAGAAGCCTAAAAAGAATGATCATAAATGTACTTCACCAGTGATTTTACTGAAATGCACTTATATTAGTCTTTATGT
ATTTGCTAGTTCAGCCTGATTTCTAGAAGAGGTTATAGTGTGAGACTTGTAGTATTCAAGTAAGATAAGTGACCTAATTTTAAAATAATT
CTTCTACTTTTCTGTATATTCAGCAGGGTATTTAAGTGCTAGGGCTGGTCACACACAACCAACTGAAAAAGACTAGAGGGATTAGTACAA
ACTCCTCTTATACAGAAGGCAAATCTGAGGTTCCACAGAAGTCTGGAACCAAGACTATTCAGTTGGTTAAATAAAGAGGTTAGTCTAGAC
TGGGCCTGCTCATTCTAGGTCACCACATTTTCCATCTCCAAATAGCCAGGCCCTCTCTCCCTCAAGAAATGCCCAGATGTAGAAATTCAT
CAGTGCCTATTGGTCTTCCAGAATTTTCCATCTTCCGTATCTCCCAGGCATGAGACTACCAAGTTTGTTTGTTTTCTTTCCAATTTGGGA
ATTTATACTTCAGTATGGTTTCAACGCAGTTATGTTTCCAGAGAACATCTAGAAGTGGCTGGAAACCAGAAGCTGGGGATTCCAGGGACC
CCACTTAGTGCTCTATTTCCTTTATAGGTTTTATTTCTGGTCATAGAGAGAGAAGGACCTTTGACTTTTTCTTCGTTGAGGCTTCTGAGG
AGGAAAAACAAACCTAAAATAGAAATACAGTCAGCCTTTCAAATCCATGGGTTCTGTGTCCGTGGATTCAACCAACCTTGGATCAAAAAT
ATTTGAAAAAAAATCTACAAAGTTTCAAAAAGCAAAACTTGAATTTGCTGCATGCCAAGAAGTATGTTGAATTCATGTAAATGAAGTGAT
GTGTAGGCATTGTATTAGATATTATAAGAAATCTAGAAATGATTTAAAGCATACAGGAGGATGTGCATAGGTTATATGCAAATACTATGC
TATTTTATATATGGGACTTGAGCATTTGTGGATTTTGATACTGGGGGATCCTGGAACCAATCCCCCATGGATACCAAAGTACGACTGTAG
TTATCTATTTTTTACATACTTATTATTACCACCATGCTCAGTAAGTCCATTTTTGCATGGAATATGGAGCCTTAAAACATGTCATGAATT
TGGAGTCCCTGGCACATAAATCTACCTTCAAATCAGAGGTCCTTAATGATGCCTAAACATACAGTAAAATTAGAATCAGAAATACTTCTT
TAAAAAATATTCAAAATGTGTTTGTTTCCCATGGGATTATTCTCTATCCCACACGAATGTAAAAAAATCCACATTAATGATCCATTTAAG
TATAGTTTTATTGGGTCCTTTTCTAATGATTAAAGGTTCTTTCTCAATTTCATTCCTCAGTCCTGCAAGTAAGGACTCATACTGAAGAGT
ACTGAAACAAGGACTTCTTGTCAGAAACAGCTTCTGGAATCTTGGGTTTTGTTTTTGTTTTTTGACAAAATACACTATTGGCCATGTCCA
TCACGAGAGTGTTTGTAGTAATTAATTACCTTGTACAGGACCTGGCACTTAGTAGCATTCTTCAAATGTTCCCTCAGTGATCCTTTTACT
CTCCTTGTCACTTATTTGGGAGAAATAGGGGCACGTGAGATAAGAAGAAGAATAATTTTGATGTTGGTATGCTTGCCCTGTTACTTATAG
ACAGTCTTTGTCATAGGCAAACTTGAATTTGATTTAAAATAGGGCTGGGAAAAATATTCAATAACTGTAAGCCCCCTTTTGGATGCCAAA
CTTAGAATTTTGTACATTCTCTGATGAACAAGCATTTAGATCGTAACATGGTAAAGCCTATTACCAGCCAATGTTGTTAGCATCTTTGTA
TGCACATCACTGTTTGTGCAATATATGAATATTTTGTTGCATTGTATTCTTATATAAAAATAAGTAGAAAACATAAAATTGAAATTGCTG

>9811_9811_2_BLNK-PIK3AP1_BLNK_chr10_97976409_ENST00000371176_PIK3AP1_chr10_98388250_ENST00000339364_length(amino acids)=562AA_BP=215
MDSYSCLLQLPNRMDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASESPADEEEQWSDDFDSDYENPDE
HSDSEMYVMPAEENADDSYEPPPVEQETRPVHPALPFARGEYIDNRSSQRHSPPFSKTLPSKPSWPSEKARLTSTLPALTALQKPQVPPK
PKGLLEDEADYVVPVEDNDENYIHPTESSSPPPEKDVEMLQASTSNPIPGDGFSRATKDSMIRKFLEGNSMGMTNLERDQCHLGQEEDVY
HTVDDDEAFSVDLASRPPVPVPRPETTAPGAHQLPDNEPYIFKVFAEKSQERPGNFYVSSESIRKGPPVRPWRDRPQSSIYDPFAGMKTP
GQRQLITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQREKQKSGKQTDLEITVPIRHSQHLPAKVEFGV
YESGPRKSVIPPRTELRRGDWKTDSTSSTASSTSNRSSTRSLLSVSSGMEGDNEDNEVPEVTRSRSPGPPQVDGTPTMSLERPPRVPPRA

--------------------------------------------------------------
>9811_9811_3_BLNK-PIK3AP1_BLNK_chr10_97976409_ENST00000413476_PIK3AP1_chr10_98388250_ENST00000339364_length(transcript)=4093nt_BP=785nt
AAGTTTTACTTCTCCCTAGAGCAGGGGTGTTTGCCAGCAGCCTGCACTCTCAGAAATCAGACTTGAGTGGCCGGAACCCTTGAGACCAGA
GGCTTACCATGCTGCTCCCTAGGAGGGCCAGGAACTGCTGACGTGACCACTGGACAGTTATTCGTGTCTCTTACAATTACCAAACAGAAT
GGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCAGAAGTTGAGGCAGCTTCAAAAGATGGTCCATGATATTAAAAACAATGAAGGTGG
AATAATGAATAAAATCAAAAAGCTAAAAGTCAAAGCACCTCCAAGTGTTCCTCGAAGGGACTACGCTTCAGAGAGCCCTGCTGACGAAGA
GGAGCAGTGGTCCGATGACTTTGACAGCGACTATGAAAATCCAGATGAGCACTCGGACTCAGAGATGTACGTGATGCCCGCCGAGGAGAA
CGCTGATGACAGCTACGAGCCGCCTCCAGTAGAGCAGGAAACCAGGCCGGTTCACCCAGCCCTGCCCTTCGCCAGAGGCGAGTATATAGA
CAATCGATCAAGCCAGAGGCATTCCCCACCCTTCAGCAAGACACTTCCCAGTAAGCCCAGCTGGCCTTCAGAGAAAGCAAGGCTCACCTC
CACCCTGCCGGCCCTGACTGCTTTGCAGAAACCTCAAGTCCCACCCAAACCCAAAGGCCTCCTTGAGGATGAGGCTGATTATGTGGTCCC
CGTGGAAGATAATGATGAAAACTATATTCATCCCACAGAAAGCAGTTCACCTCCACCTGAAAAAGATGTTGAAATGCTTCAGGCCAGTAC
ATCTAACCCAATCCCTGGAGATGGTTTCTCTCGGGCCACTAAGGACTCTATGATCCGCAAGTTTTTAGAAGGCAACAGCATGGGAATGAC
CAATCTGGAGAGAGATCAGTGCCATCTTGGTCAGGAAGAAGATGTTTATCACACGGTGGATGACGATGAGGCCTTTTCTGTGGACCTGGC
CAGCAGGCCCCCTGTCCCAGTGCCCAGACCAGAGACCACTGCTCCTGGTGCTCACCAGCTGCCTGACAACGAACCATACATTTTTAAAGT
TTTTGCAGAAAAAAGTCAAGAGCGGCCTGGGAATTTCTACGTTTCCTCAGAGAGCATCAGGAAAGGGCCGCCCGTCAGACCATGGAGGGA
CAGGCCCCAGTCGAGTATATATGACCCTTTTGCGGGAATGAAAACGCCAGGCCAGCGGCAGCTTATCACCCTCCAGGAGCAGGTGAAGCT
GGGCATTGTCAACGTGGATGAGGCTGTGCTCCACTTCAAAGAGTGGCAGCTCAACCAGAAGAAACGATCGGAGTCCTTTCGTTTCCAGCA
GGAAAATCTTAAACGGCTAAGAGACAGCATCACCCGAAGACAGAGAGAGAAGCAAAAATCAGGAAAGCAGACAGACTTGGAGATCACGGT
CCCAATTCGGCACTCACAGCACCTGCCTGCAAAAGTGGAGTTTGGAGTCTATGAGAGTGGCCCCAGGAAAAGTGTCATTCCCCCTAGGAC
GGAGCTGAGACGAGGAGACTGGAAAACAGACAGCACCTCCAGCACAGCAAGTAGCACAAGTAACCGCTCCAGCACCCGGAGCCTCCTCAG
TGTGAGCAGCGGGATGGAAGGGGACAACGAGGATAATGAAGTCCCTGAGGTTACCAGAAGTCGCAGTCCAGGCCCCCCACAAGTGGATGG
GACACCCACCATGTCCCTCGAGAGACCCCCCAGGGTGCCTCCGAGAGCTGCCTCACAGAGGCCTCCGACCAGGGAGACCTTCCATCCTCC
TCCACCTGTTCCACCCAGAGGACGCTGATTCCACCTCCTAAAACCTGCCTACTTCAGGACTTTAAGACTCACAGTCTTCAGCCTGTTAAT
GATGTCTTCATGTTGAGTTTTATAGCATGACTGTTGACCTTAAGATCCATTCTCATTGCTGATAATGCTGCAGCCCTGCTGGTTTGGGCT
TGCCTCGAAGATTTTATTAAGGCACGAAGAAGTGAAAAACTAAGGGCTTCATTCACCATCACCAAGTATATCGAACCATATACTTGTTTG
CCAAAAGGATGAAGACTTAATCGAAATACTTACCTCTAATTTGCCATATCAGAAGCCTAAAAAGAATGATCATAAATGTACTTCACCAGT
GATTTTACTGAAATGCACTTATATTAGTCTTTATGTATTTGCTAGTTCAGCCTGATTTCTAGAAGAGGTTATAGTGTGAGACTTGTAGTA
TTCAAGTAAGATAAGTGACCTAATTTTAAAATAATTCTTCTACTTTTCTGTATATTCAGCAGGGTATTTAAGTGCTAGGGCTGGTCACAC
ACAACCAACTGAAAAAGACTAGAGGGATTAGTACAAACTCCTCTTATACAGAAGGCAAATCTGAGGTTCCACAGAAGTCTGGAACCAAGA
CTATTCAGTTGGTTAAATAAAGAGGTTAGTCTAGACTGGGCCTGCTCATTCTAGGTCACCACATTTTCCATCTCCAAATAGCCAGGCCCT
CTCTCCCTCAAGAAATGCCCAGATGTAGAAATTCATCAGTGCCTATTGGTCTTCCAGAATTTTCCATCTTCCGTATCTCCCAGGCATGAG
ACTACCAAGTTTGTTTGTTTTCTTTCCAATTTGGGAATTTATACTTCAGTATGGTTTCAACGCAGTTATGTTTCCAGAGAACATCTAGAA
GTGGCTGGAAACCAGAAGCTGGGGATTCCAGGGACCCCACTTAGTGCTCTATTTCCTTTATAGGTTTTATTTCTGGTCATAGAGAGAGAA
GGACCTTTGACTTTTTCTTCGTTGAGGCTTCTGAGGAGGAAAAACAAACCTAAAATAGAAATACAGTCAGCCTTTCAAATCCATGGGTTC
TGTGTCCGTGGATTCAACCAACCTTGGATCAAAAATATTTGAAAAAAAATCTACAAAGTTTCAAAAAGCAAAACTTGAATTTGCTGCATG
CCAAGAAGTATGTTGAATTCATGTAAATGAAGTGATGTGTAGGCATTGTATTAGATATTATAAGAAATCTAGAAATGATTTAAAGCATAC
AGGAGGATGTGCATAGGTTATATGCAAATACTATGCTATTTTATATATGGGACTTGAGCATTTGTGGATTTTGATACTGGGGGATCCTGG
AACCAATCCCCCATGGATACCAAAGTACGACTGTAGTTATCTATTTTTTACATACTTATTATTACCACCATGCTCAGTAAGTCCATTTTT
GCATGGAATATGGAGCCTTAAAACATGTCATGAATTTGGAGTCCCTGGCACATAAATCTACCTTCAAATCAGAGGTCCTTAATGATGCCT
AAACATACAGTAAAATTAGAATCAGAAATACTTCTTTAAAAAATATTCAAAATGTGTTTGTTTCCCATGGGATTATTCTCTATCCCACAC
GAATGTAAAAAAATCCACATTAATGATCCATTTAAGTATAGTTTTATTGGGTCCTTTTCTAATGATTAAAGGTTCTTTCTCAATTTCATT
CCTCAGTCCTGCAAGTAAGGACTCATACTGAAGAGTACTGAAACAAGGACTTCTTGTCAGAAACAGCTTCTGGAATCTTGGGTTTTGTTT
TTGTTTTTTGACAAAATACACTATTGGCCATGTCCATCACGAGAGTGTTTGTAGTAATTAATTACCTTGTACAGGACCTGGCACTTAGTA
GCATTCTTCAAATGTTCCCTCAGTGATCCTTTTACTCTCCTTGTCACTTATTTGGGAGAAATAGGGGCACGTGAGATAAGAAGAAGAATA
ATTTTGATGTTGGTATGCTTGCCCTGTTACTTATAGACAGTCTTTGTCATAGGCAAACTTGAATTTGATTTAAAATAGGGCTGGGAAAAA
TATTCAATAACTGTAAGCCCCCTTTTGGATGCCAAACTTAGAATTTTGTACATTCTCTGATGAACAAGCATTTAGATCGTAACATGGTAA
AGCCTATTACCAGCCAATGTTGTTAGCATCTTTGTATGCACATCACTGTTTGTGCAATATATGAATATTTTGTTGCATTGTATTCTTATA

>9811_9811_3_BLNK-PIK3AP1_BLNK_chr10_97976409_ENST00000413476_PIK3AP1_chr10_98388250_ENST00000339364_length(amino acids)=562AA_BP=215
MDSYSCLLQLPNRMDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASESPADEEEQWSDDFDSDYENPDE
HSDSEMYVMPAEENADDSYEPPPVEQETRPVHPALPFARGEYIDNRSSQRHSPPFSKTLPSKPSWPSEKARLTSTLPALTALQKPQVPPK
PKGLLEDEADYVVPVEDNDENYIHPTESSSPPPEKDVEMLQASTSNPIPGDGFSRATKDSMIRKFLEGNSMGMTNLERDQCHLGQEEDVY
HTVDDDEAFSVDLASRPPVPVPRPETTAPGAHQLPDNEPYIFKVFAEKSQERPGNFYVSSESIRKGPPVRPWRDRPQSSIYDPFAGMKTP
GQRQLITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQREKQKSGKQTDLEITVPIRHSQHLPAKVEFGV
YESGPRKSVIPPRTELRRGDWKTDSTSSTASSTSNRSSTRSLLSVSSGMEGDNEDNEVPEVTRSRSPGPPQVDGTPTMSLERPPRVPPRA

--------------------------------------------------------------
>9811_9811_4_BLNK-PIK3AP1_BLNK_chr10_97976409_ENST00000427367_PIK3AP1_chr10_98388250_ENST00000339364_length(transcript)=4093nt_BP=785nt
AAGTTTTACTTCTCCCTAGAGCAGGGGTGTTTGCCAGCAGCCTGCACTCTCAGAAATCAGACTTGAGTGGCCGGAACCCTTGAGACCAGA
GGCTTACCATGCTGCTCCCTAGGAGGGCCAGGAACTGCTGACGTGACCACTGGACAGTTATTCGTGTCTCTTACAATTACCAAACAGAAT
GGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCAGAAGTTGAGGCAGCTTCAAAAGATGGTCCATGATATTAAAAACAATGAAGGTGG
AATAATGAATAAAATCAAAAAGCTAAAAGTCAAAGCACCTCCAAGTGTTCCTCGAAGGGACTACGCTTCAGAGAGCCCTGCTGACGAAGA
GGAGCAGTGGTCCGATGACTTTGACAGCGACTATGAAAATCCAGATGAGCACTCGGACTCAGAGATGTACGTGATGCCCGCCGAGGAGAA
CGCTGATGACAGCTACGAGCCGCCTCCAGTAGAGCAGGAAACCAGGCCGGTTCACCCAGCCCTGCCCTTCGCCAGAGGCGAGTATATAGA
CAATCGATCAAGCCAGAGGCATTCCCCACCCTTCAGCAAGACACTTCCCAGTAAGCCCAGCTGGCCTTCAGAGAAAGCAAGGCTCACCTC
CACCCTGCCGGCCCTGACTGCTTTGCAGAAACCTCAAGTCCCACCCAAACCCAAAGGCCTCCTTGAGGATGAGGCTGATTATGTGGTCCC
CGTGGAAGATAATGATGAAAACTATATTCATCCCACAGAAAGCAGTTCACCTCCACCTGAAAAAGATGTTGAAATGCTTCAGGCCAGTAC
ATCTAACCCAATCCCTGGAGATGGTTTCTCTCGGGCCACTAAGGACTCTATGATCCGCAAGTTTTTAGAAGGCAACAGCATGGGAATGAC
CAATCTGGAGAGAGATCAGTGCCATCTTGGTCAGGAAGAAGATGTTTATCACACGGTGGATGACGATGAGGCCTTTTCTGTGGACCTGGC
CAGCAGGCCCCCTGTCCCAGTGCCCAGACCAGAGACCACTGCTCCTGGTGCTCACCAGCTGCCTGACAACGAACCATACATTTTTAAAGT
TTTTGCAGAAAAAAGTCAAGAGCGGCCTGGGAATTTCTACGTTTCCTCAGAGAGCATCAGGAAAGGGCCGCCCGTCAGACCATGGAGGGA
CAGGCCCCAGTCGAGTATATATGACCCTTTTGCGGGAATGAAAACGCCAGGCCAGCGGCAGCTTATCACCCTCCAGGAGCAGGTGAAGCT
GGGCATTGTCAACGTGGATGAGGCTGTGCTCCACTTCAAAGAGTGGCAGCTCAACCAGAAGAAACGATCGGAGTCCTTTCGTTTCCAGCA
GGAAAATCTTAAACGGCTAAGAGACAGCATCACCCGAAGACAGAGAGAGAAGCAAAAATCAGGAAAGCAGACAGACTTGGAGATCACGGT
CCCAATTCGGCACTCACAGCACCTGCCTGCAAAAGTGGAGTTTGGAGTCTATGAGAGTGGCCCCAGGAAAAGTGTCATTCCCCCTAGGAC
GGAGCTGAGACGAGGAGACTGGAAAACAGACAGCACCTCCAGCACAGCAAGTAGCACAAGTAACCGCTCCAGCACCCGGAGCCTCCTCAG
TGTGAGCAGCGGGATGGAAGGGGACAACGAGGATAATGAAGTCCCTGAGGTTACCAGAAGTCGCAGTCCAGGCCCCCCACAAGTGGATGG
GACACCCACCATGTCCCTCGAGAGACCCCCCAGGGTGCCTCCGAGAGCTGCCTCACAGAGGCCTCCGACCAGGGAGACCTTCCATCCTCC
TCCACCTGTTCCACCCAGAGGACGCTGATTCCACCTCCTAAAACCTGCCTACTTCAGGACTTTAAGACTCACAGTCTTCAGCCTGTTAAT
GATGTCTTCATGTTGAGTTTTATAGCATGACTGTTGACCTTAAGATCCATTCTCATTGCTGATAATGCTGCAGCCCTGCTGGTTTGGGCT
TGCCTCGAAGATTTTATTAAGGCACGAAGAAGTGAAAAACTAAGGGCTTCATTCACCATCACCAAGTATATCGAACCATATACTTGTTTG
CCAAAAGGATGAAGACTTAATCGAAATACTTACCTCTAATTTGCCATATCAGAAGCCTAAAAAGAATGATCATAAATGTACTTCACCAGT
GATTTTACTGAAATGCACTTATATTAGTCTTTATGTATTTGCTAGTTCAGCCTGATTTCTAGAAGAGGTTATAGTGTGAGACTTGTAGTA
TTCAAGTAAGATAAGTGACCTAATTTTAAAATAATTCTTCTACTTTTCTGTATATTCAGCAGGGTATTTAAGTGCTAGGGCTGGTCACAC
ACAACCAACTGAAAAAGACTAGAGGGATTAGTACAAACTCCTCTTATACAGAAGGCAAATCTGAGGTTCCACAGAAGTCTGGAACCAAGA
CTATTCAGTTGGTTAAATAAAGAGGTTAGTCTAGACTGGGCCTGCTCATTCTAGGTCACCACATTTTCCATCTCCAAATAGCCAGGCCCT
CTCTCCCTCAAGAAATGCCCAGATGTAGAAATTCATCAGTGCCTATTGGTCTTCCAGAATTTTCCATCTTCCGTATCTCCCAGGCATGAG
ACTACCAAGTTTGTTTGTTTTCTTTCCAATTTGGGAATTTATACTTCAGTATGGTTTCAACGCAGTTATGTTTCCAGAGAACATCTAGAA
GTGGCTGGAAACCAGAAGCTGGGGATTCCAGGGACCCCACTTAGTGCTCTATTTCCTTTATAGGTTTTATTTCTGGTCATAGAGAGAGAA
GGACCTTTGACTTTTTCTTCGTTGAGGCTTCTGAGGAGGAAAAACAAACCTAAAATAGAAATACAGTCAGCCTTTCAAATCCATGGGTTC
TGTGTCCGTGGATTCAACCAACCTTGGATCAAAAATATTTGAAAAAAAATCTACAAAGTTTCAAAAAGCAAAACTTGAATTTGCTGCATG
CCAAGAAGTATGTTGAATTCATGTAAATGAAGTGATGTGTAGGCATTGTATTAGATATTATAAGAAATCTAGAAATGATTTAAAGCATAC
AGGAGGATGTGCATAGGTTATATGCAAATACTATGCTATTTTATATATGGGACTTGAGCATTTGTGGATTTTGATACTGGGGGATCCTGG
AACCAATCCCCCATGGATACCAAAGTACGACTGTAGTTATCTATTTTTTACATACTTATTATTACCACCATGCTCAGTAAGTCCATTTTT
GCATGGAATATGGAGCCTTAAAACATGTCATGAATTTGGAGTCCCTGGCACATAAATCTACCTTCAAATCAGAGGTCCTTAATGATGCCT
AAACATACAGTAAAATTAGAATCAGAAATACTTCTTTAAAAAATATTCAAAATGTGTTTGTTTCCCATGGGATTATTCTCTATCCCACAC
GAATGTAAAAAAATCCACATTAATGATCCATTTAAGTATAGTTTTATTGGGTCCTTTTCTAATGATTAAAGGTTCTTTCTCAATTTCATT
CCTCAGTCCTGCAAGTAAGGACTCATACTGAAGAGTACTGAAACAAGGACTTCTTGTCAGAAACAGCTTCTGGAATCTTGGGTTTTGTTT
TTGTTTTTTGACAAAATACACTATTGGCCATGTCCATCACGAGAGTGTTTGTAGTAATTAATTACCTTGTACAGGACCTGGCACTTAGTA
GCATTCTTCAAATGTTCCCTCAGTGATCCTTTTACTCTCCTTGTCACTTATTTGGGAGAAATAGGGGCACGTGAGATAAGAAGAAGAATA
ATTTTGATGTTGGTATGCTTGCCCTGTTACTTATAGACAGTCTTTGTCATAGGCAAACTTGAATTTGATTTAAAATAGGGCTGGGAAAAA
TATTCAATAACTGTAAGCCCCCTTTTGGATGCCAAACTTAGAATTTTGTACATTCTCTGATGAACAAGCATTTAGATCGTAACATGGTAA
AGCCTATTACCAGCCAATGTTGTTAGCATCTTTGTATGCACATCACTGTTTGTGCAATATATGAATATTTTGTTGCATTGTATTCTTATA

>9811_9811_4_BLNK-PIK3AP1_BLNK_chr10_97976409_ENST00000427367_PIK3AP1_chr10_98388250_ENST00000339364_length(amino acids)=562AA_BP=215
MDSYSCLLQLPNRMDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASESPADEEEQWSDDFDSDYENPDE
HSDSEMYVMPAEENADDSYEPPPVEQETRPVHPALPFARGEYIDNRSSQRHSPPFSKTLPSKPSWPSEKARLTSTLPALTALQKPQVPPK
PKGLLEDEADYVVPVEDNDENYIHPTESSSPPPEKDVEMLQASTSNPIPGDGFSRATKDSMIRKFLEGNSMGMTNLERDQCHLGQEEDVY
HTVDDDEAFSVDLASRPPVPVPRPETTAPGAHQLPDNEPYIFKVFAEKSQERPGNFYVSSESIRKGPPVRPWRDRPQSSIYDPFAGMKTP
GQRQLITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQREKQKSGKQTDLEITVPIRHSQHLPAKVEFGV
YESGPRKSVIPPRTELRRGDWKTDSTSSTASSTSNRSSTRSLLSVSSGMEGDNEDNEVPEVTRSRSPGPPQVDGTPTMSLERPPRVPPRA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BLNK-PIK3AP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BLNK-PIK3AP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BLNK-PIK3AP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBLNKC0001768Agammaglobulinemia1CTD_human;GENOMICS_ENGLAND
HgeneBLNKC1832241Agammaglobulinemia, non-Bruton type1ORPHANET
HgeneBLNKC3150752AGAMMAGLOBULINEMIA 4, AUTOSOMAL RECESSIVE1GENOMICS_ENGLAND