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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CYP2S1-UPF1 (FusionGDB2 ID:HG29785TG5976)

Fusion Gene Summary for CYP2S1-UPF1

check button Fusion gene summary
Fusion gene informationFusion gene name: CYP2S1-UPF1
Fusion gene ID: hg29785tg5976
HgeneTgene
Gene symbol

CYP2S1

UPF1

Gene ID

29785

5976

Gene namecytochrome P450 family 2 subfamily S member 1UPF1 RNA helicase and ATPase
SynonymsCYPIIS1HUPF1|NORF1|RENT1|pNORF1|smg-2
Cytomap('CYP2S1')('UPF1')

19q13.2

19p13.11

Type of geneprotein-codingprotein-coding
Descriptioncytochrome P450 2S1cytochrome P450, family 2, subfamily S, polypeptide 1cytochrome P540, subfamily IIS, polypeptide 1hydroperoxy icosatetraenoate dehydratasethromboxane-A synthaseregulator of nonsense transcripts 1ATP-dependent helicase RENT1UPF1 regulator of nonsense transcripts homologdelta helicasenonsense mRNA reducing factor 1smg-2 homolog, nonsense mediated mRNA decay factorup-frameshift mutation 1 homologup-frameshif
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000310054, ENST00000542619, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 7 X 5=280
# samples 19
** MAII scorelog2(1/1*10)=3.32192809488736log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CYP2S1 [Title/Abstract] AND UPF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCYP2S1(41703833)-UPF1(18976098), # samples:1
Anticipated loss of major functional domain due to fusion event.CYP2S1-UPF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CYP2S1-UPF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CYP2S1-UPF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CYP2S1-UPF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCYP2S1

GO:0006690

icosanoid metabolic process

21068195

HgeneCYP2S1

GO:0006693

prostaglandin metabolic process

21068195

HgeneCYP2S1

GO:0042573

retinoic acid metabolic process

12711469

TgeneUPF1

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

17468741

TgeneUPF1

GO:0006281

DNA repair

16488880

TgeneUPF1

GO:0032201

telomere maintenance via semi-conservative replication

21829167

TgeneUPF1

GO:0061014

positive regulation of mRNA catabolic process

24726324

TgeneUPF1

GO:0061158

3'-UTR-mediated mRNA destabilization

24726324

TgeneUPF1

GO:0071222

cellular response to lipopolysaccharide

26255671

TgeneUPF1

GO:0071347

cellular response to interleukin-1

26255671


check buttonFusion gene breakpoints across CYP2S1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across UPF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-34-5240-01ACYP2S1chr19

41703833

+UPF1chr19

18976098

+


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Fusion Gene ORF analysis for CYP2S1-UPF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000310054ENST00000600310CYP2S1chr19

41703833

+UPF1chr19

18976098

+
In-frameENST00000310054ENST00000262803CYP2S1chr19

41703833

+UPF1chr19

18976098

+
In-frameENST00000310054ENST00000599848CYP2S1chr19

41703833

+UPF1chr19

18976098

+
intron-3CDSENST00000542619ENST00000262803CYP2S1chr19

41703833

+UPF1chr19

18976098

+
intron-3CDSENST00000542619ENST00000599848CYP2S1chr19

41703833

+UPF1chr19

18976098

+
intron-intronENST00000542619ENST00000600310CYP2S1chr19

41703833

+UPF1chr19

18976098

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000310054CYP2S1chr1941703833+ENST00000262803UPF1chr1918976098+29287091051208367
ENST00000310054CYP2S1chr1941703833+ENST00000599848UPF1chr1918976098+29217091051208367

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000310054ENST00000262803CYP2S1chr1941703833+UPF1chr1918976098+0.0095184660.99048156
ENST00000310054ENST00000599848CYP2S1chr1941703833+UPF1chr1918976098+0.0094342850.9905657

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Fusion Genomic Features for CYP2S1-UPF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CYP2S1chr1941703833+UPF1chr1918976097+0.0003883310.9996117
CYP2S1chr1941703833+UPF1chr1918976097+0.0003883310.9996117

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CYP2S1-UPF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:41703833/chr19:18976098)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUPF1chr19:41703833chr19:18976098ENST0000026280319241042_11299521523.3333333333333Compositional biasNote=Gln/Ser-rich
TgeneUPF1chr19:41703833chr19:18976098ENST0000059984819241042_11299631553.0Compositional biasNote=Gln/Ser-rich
TgeneUPF1chr19:41703833chr19:18976098ENST0000026280319241089_10909521523.3333333333333MotifNote=[ST]-Q motif 1
TgeneUPF1chr19:41703833chr19:18976098ENST0000026280319241107_11089521523.3333333333333MotifNote=[ST]-Q motif 2
TgeneUPF1chr19:41703833chr19:18976098ENST0000059984819241089_10909631553.0MotifNote=[ST]-Q motif 1
TgeneUPF1chr19:41703833chr19:18976098ENST0000059984819241107_11089631553.0MotifNote=[ST]-Q motif 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUPF1chr19:41703833chr19:18976098ENST00000262803192447_809521523.3333333333333Compositional biasNote=Ala/Gly/Pro-rich
TgeneUPF1chr19:41703833chr19:18976098ENST00000599848192447_809631553.0Compositional biasNote=Ala/Gly/Pro-rich
TgeneUPF1chr19:41703833chr19:18976098ENST000002628031924506_5109521523.3333333333333Nucleotide bindingNote=ATP
TgeneUPF1chr19:41703833chr19:18976098ENST000005998481924506_5109631553.0Nucleotide bindingNote=ATP
TgeneUPF1chr19:41703833chr19:18976098ENST000002628031924121_2729521523.3333333333333Zinc fingerNote=UPF1-type
TgeneUPF1chr19:41703833chr19:18976098ENST000005998481924121_2729631553.0Zinc fingerNote=UPF1-type


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Fusion Gene Sequence for CYP2S1-UPF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21065_21065_1_CYP2S1-UPF1_CYP2S1_chr19_41703833_ENST00000310054_UPF1_chr19_18976098_ENST00000262803_length(transcript)=2928nt_BP=709nt
ACATCCGTTGGAGCATGAGTTCCCGACATCAGGCGGCGGCGGTGGTCCGGGAGAAACCCGGCGGCGGGGAGATAAGCCTGCCCAGGAGGC
AGGGGGCTGGGCTAGCTGCCCCGCCCCGCGCCTGACTTCGTTGGGGAGGGAGACGCCCGGCTCCCGCCCCTAACTAGCCCAGCCGCGCGG
AGCGCCTGGGAGAGGAGAAGGAGCCGACCTGCCGAGATGGAGGCGACCGGCACCTGGGCGCTGCTGCTGGCGCTGGCGCTGCTCCTGCTG
CTGACGCTGGCGCTGTCCGGGACCAGGGCCCGAGGCCACCTGCCCCCCGGGCCCACGCCGCTACCACTGCTGGGAAACCTCCTGCAGCTA
CGGCCCGGGGCGCTGTATTCAGGGCTCATGCGGCTGAGTAAGAAGTACGGACCGGTGTTCACCATCTACCTGGGACCGTGGCGGCCTGTG
GTGGTCCTGGTTGGGCAGGAGGCTGTGCGGGAGGCCCTGGGAGGTCAGGCTGAGGAGTTCAGCGGCCGGGGAACCGTAGCGATGCTGGAA
GGGACTTTTGATGGCCATGGGGTTTTCTTCTCCAACGGGGAGCGGTGGAGGCAGCTGAGGAAGTTTACCATGCTTGCTCTGCGGGACCTG
GGCATGGGGAAGCGAGAAGGCGAGGAGCTGATCCAGGCGGAGGCCCGGTGTCTGGTGGAGACATTCCAGGGGACAGAAGGCCGGCCTTCC
AGCATGTACTTCCAGACCCATGACCAGATTGGCATGATCAGTGCCGGCCCTAGCCACGTGGCTGCCATGAACATTCCCATCCCCTTCAAC
CTGGTCATGCCACCCATGCCACCGCCTGGCTATTTTGGACAAGCCAACGGGCCTGCTGCAGGGCGAGGCACCCCGAAAGGCAAGACTGGT
CGTGGGGGACGCCAGAAGAACCGCTTTGGGCTTCCTGGACCCAGCCAGACTAACCTCCCCAACAGCCAAGCCAGCCAGGATGTGGCGTCA
CAGCCCTTCTCTCAGGGCGCCCTGACGCAGGGCTACATCTCCATGAGCCAGCCTTCCCAGATGAGCCAGCCCGGCCTCTCCCAGCCGGAG
CTGTCCCAGGACAGTTACCTTGGTGACGAGTTTAAATCACAAATCGACGTGGCGCTCTCACAGGACTCCACGTACCAGGGAGAGCGGGCT
TACCAGCATGGCGGGGTGACGGGGCTGTCCCAGTATTAAAAGGTGGCGGCGGAAGAGCTAAGCAACGTGGCTTAGTCCATCAGCATCTTA
TTCTGGGTAATAAAAAATAAAAATAAACGGATACCTGTTTTCCACTGCTAAAACTGAAGCACCACTGTGTGAGCAACAGGAAGGGAGAGC
GCACGAGGGAGAGGAGCCGAGGCCGAGCGCCCCCTGCTGGCCCGCGGCGGCGAGGAGCAGAGGGAGCGGAGGAGGGGCCGGCCCGCGGGA
GCCGCGGCCACCAGGAGGCCCCGCTCCGTCCCATCGGGGCTGCGGCCAGGGCGGAGGGAGGAAGACCCTCATCTCAGAGTAGCCCTTTCC
TCTGTTCTTTTATTTCTTTTTCTCTTTGATTGAAAGGGGACTACGTCTTAGCAGGAAAAAAAACTTCGCATTTCTGTGCCCGAGCAGGCT
CCTTGCAAAGACAGCAGCGTGCGGGGCAGAGCCCCGGGAGGGCGCGTCTGTCCACGCCTACCGGACGCGCCGAGGTCGCGCTGCCTGTGT
TCTCCGAGGGCCTTCATTTAAAGAAAATAAGGGTGTTTTGGGTTTTTCTCTTTGTTTTTTTCAAGATTCTTTTAAAGGAGTACTGAAGAA
TACTTTCCTAAGTTTGTCTGTAAAATCTTAGCGGTGGACCTGGGAGATTTGAGAAGCTTCCAGAAACAGTTTAAACAAGCCAGCGCTACT
GGAGAAGAGGAGCAACACCTGTGCCGCGGCCGGAGGAGTTTTGTTGTTGGTTTTAGCTTCCAGTGGCTTCTTTCTGCGGGGCATCAGGCT
GCTGGGGTAGCCGCCCGCCGAGCCTGGAAGCTGCTCGTTCTCCGCTGGACTCAGAAGCCAAGCTGCTTCCCGCCTAGACTCGGCGCAGGG
CCCCGCACCGGTGAGGAAGGTGCTTTTGGCCCCATTGCGAGGGGCCTTGGCCAGGACTGGCCCTGTGGCCAGGAGGCGAGAAGGTGGCTG
TTCCCGGATTGACGGCTTTTTCCCGGGGGCCTTTGGAAGATTTGGTGGAAGGACAAGAGGGCCTGTCCCTGTCCCCGTCCCCAGGAGGTA
CCGACAGTCCCTGTGCTGGTTAGACACGGAGCGCTGCACACCGAAAGCCCAAATTGGGAGCTCTGCCTGCCGGCAACTTTGCTGATGGGG
TGATTGCTGCTTCTGGGGGGTAAGGAAACAAGTTACAGAAATTACCGCGTTCTGTGTGAAGGGACTGAGGGTGTGGTGTCATTGGCAGAG
GGTCATTTTAGGAGAGCTGCCCCAGCCCCTCGAACGCCTGGCTTGGGGTGTCATTCTGCCTGGCGGCCAGGCCTCCAGCTTCCCCTGCCC
CGGGCCTGGGGCTGTCACTGGCCCTGATCCGAACACCTCCAGATTCCGGCTTCTACATGGGACAGACGGGGACGCACAGGCCACCTTCCT
TCTGGCAGGGACTCTTATTTATTCCCATTGCTCTAGGGCTTTCGGTTTCCCCTTCTTCCGGTAGGCCGCGTAGAGGCATGCACCGGGTAG
GTTTCCGCGGTGACCCCGCGGCGGCCTGAGGGACGCTCCCTGCCCCATCCCGGCTGTTGGGCTGGGCCGCTTTGCCTCTGCTTCGCCCTG
TGCTGTGTTCTCCAGCTTTGTAGCAGCAGCCTTGACAAACCCAGGCGCACTGTACCAAGGCAATGTAACTTTTGATTTTCGGTCAATTTA

>21065_21065_1_CYP2S1-UPF1_CYP2S1_chr19_41703833_ENST00000310054_UPF1_chr19_18976098_ENST00000262803_length(amino acids)=367AA_BP=43
MPRPAPDFVGEGDARLPPLTSPAARSAWERRRSRPAEMEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGAL
YSGLMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKR
EGEELIQAEARCLVETFQGTEGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAGRGTPKGKTGRGGRQ
KNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISMSQPSQMSQPGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGG

--------------------------------------------------------------
>21065_21065_2_CYP2S1-UPF1_CYP2S1_chr19_41703833_ENST00000310054_UPF1_chr19_18976098_ENST00000599848_length(transcript)=2921nt_BP=709nt
ACATCCGTTGGAGCATGAGTTCCCGACATCAGGCGGCGGCGGTGGTCCGGGAGAAACCCGGCGGCGGGGAGATAAGCCTGCCCAGGAGGC
AGGGGGCTGGGCTAGCTGCCCCGCCCCGCGCCTGACTTCGTTGGGGAGGGAGACGCCCGGCTCCCGCCCCTAACTAGCCCAGCCGCGCGG
AGCGCCTGGGAGAGGAGAAGGAGCCGACCTGCCGAGATGGAGGCGACCGGCACCTGGGCGCTGCTGCTGGCGCTGGCGCTGCTCCTGCTG
CTGACGCTGGCGCTGTCCGGGACCAGGGCCCGAGGCCACCTGCCCCCCGGGCCCACGCCGCTACCACTGCTGGGAAACCTCCTGCAGCTA
CGGCCCGGGGCGCTGTATTCAGGGCTCATGCGGCTGAGTAAGAAGTACGGACCGGTGTTCACCATCTACCTGGGACCGTGGCGGCCTGTG
GTGGTCCTGGTTGGGCAGGAGGCTGTGCGGGAGGCCCTGGGAGGTCAGGCTGAGGAGTTCAGCGGCCGGGGAACCGTAGCGATGCTGGAA
GGGACTTTTGATGGCCATGGGGTTTTCTTCTCCAACGGGGAGCGGTGGAGGCAGCTGAGGAAGTTTACCATGCTTGCTCTGCGGGACCTG
GGCATGGGGAAGCGAGAAGGCGAGGAGCTGATCCAGGCGGAGGCCCGGTGTCTGGTGGAGACATTCCAGGGGACAGAAGGCCGGCCTTCC
AGCATGTACTTCCAGACCCATGACCAGATTGGCATGATCAGTGCCGGCCCTAGCCACGTGGCTGCCATGAACATTCCCATCCCCTTCAAC
CTGGTCATGCCACCCATGCCACCGCCTGGCTATTTTGGACAAGCCAACGGGCCTGCTGCAGGGCGAGGCACCCCGAAAGGCAAGACTGGT
CGTGGGGGACGCCAGAAGAACCGCTTTGGGCTTCCTGGACCCAGCCAGACTAACCTCCCCAACAGCCAAGCCAGCCAGGATGTGGCGTCA
CAGCCCTTCTCTCAGGGCGCCCTGACGCAGGGCTACATCTCCATGAGCCAGCCTTCCCAGATGAGCCAGCCCGGCCTCTCCCAGCCGGAG
CTGTCCCAGGACAGTTACCTTGGTGACGAGTTTAAATCACAAATCGACGTGGCGCTCTCACAGGACTCCACGTACCAGGGAGAGCGGGCT
TACCAGCATGGCGGGGTGACGGGGCTGTCCCAGTATTAAAAGGTGGCGGCGGAAGAGCTAAGCAACGTGGCTTAGTCCATCAGCATCTTA
TTCTGGGTAATAAAAAATAAAAATAAACGGATACCTGTTTTCCACTGCTAAAACTGAAGCACCACTGTGTGAGCAACAGGAAGGGAGAGC
GCACGAGGGAGAGGAGCCGAGGCCGAGCGCCCCCTGCTGGCCCGCGGCGGCGAGGAGCAGAGGGAGCGGAGGAGGGGCCGGCCCGCGGGA
GCCGCGGCCACCAGGAGGCCCCGCTCCGTCCCATCGGGGCTGCGGCCAGGGCGGAGGGAGGAAGACCCTCATCTCAGAGTAGCCCTTTCC
TCTGTTCTTTTATTTCTTTTTCTCTTTGATTGAAAGGGGACTACGTCTTAGCAGGAAAAAAAACTTCGCATTTCTGTGCCCGAGCAGGCT
CCTTGCAAAGACAGCAGCGTGCGGGGCAGAGCCCCGGGAGGGCGCGTCTGTCCACGCCTACCGGACGCGCCGAGGTCGCGCTGCCTGTGT
TCTCCGAGGGCCTTCATTTAAAGAAAATAAGGGTGTTTTGGGTTTTTCTCTTTGTTTTTTTCAAGATTCTTTTAAAGGAGTACTGAAGAA
TACTTTCCTAAGTTTGTCTGTAAAATCTTAGCGGTGGACCTGGGAGATTTGAGAAGCTTCCAGAAACAGTTTAAACAAGCCAGCGCTACT
GGAGAAGAGGAGCAACACCTGTGCCGCGGCCGGAGGAGTTTTGTTGTTGGTTTTAGCTTCCAGTGGCTTCTTTCTGCGGGGCATCAGGCT
GCTGGGGTAGCCGCCCGCCGAGCCTGGAAGCTGCTCGTTCTCCGCTGGACTCAGAAGCCAAGCTGCTTCCCGCCTAGACTCGGCGCAGGG
CCCCGCACCGGTGAGGAAGGTGCTTTTGGCCCCATTGCGAGGGGCCTTGGCCAGGACTGGCCCTGTGGCCAGGAGGCGAGAAGGTGGCTG
TTCCCGGATTGACGGCTTTTTCCCGGGGGCCTTTGGAAGATTTGGTGGAAGGACAAGAGGGCCTGTCCCTGTCCCCGTCCCCAGGAGGTA
CCGACAGTCCCTGTGCTGGTTAGACACGGAGCGCTGCACACCGAAAGCCCAAATTGGGAGCTCTGCCTGCCGGCAACTTTGCTGATGGGG
TGATTGCTGCTTCTGGGGGGTAAGGAAACAAGTTACAGAAATTACCGCGTTCTGTGTGAAGGGACTGAGGGTGTGGTGTCATTGGCAGAG
GGTCATTTTAGGAGAGCTGCCCCAGCCCCTCGAACGCCTGGCTTGGGGTGTCATTCTGCCTGGCGGCCAGGCCTCCAGCTTCCCCTGCCC
CGGGCCTGGGGCTGTCACTGGCCCTGATCCGAACACCTCCAGATTCCGGCTTCTACATGGGACAGACGGGGACGCACAGGCCACCTTCCT
TCTGGCAGGGACTCTTATTTATTCCCATTGCTCTAGGGCTTTCGGTTTCCCCTTCTTCCGGTAGGCCGCGTAGAGGCATGCACCGGGTAG
GTTTCCGCGGTGACCCCGCGGCGGCCTGAGGGACGCTCCCTGCCCCATCCCGGCTGTTGGGCTGGGCCGCTTTGCCTCTGCTTCGCCCTG
TGCTGTGTTCTCCAGCTTTGTAGCAGCAGCCTTGACAAACCCAGGCGCACTGTACCAAGGCAATGTAACTTTTGATTTTCGGTCAATTTA

>21065_21065_2_CYP2S1-UPF1_CYP2S1_chr19_41703833_ENST00000310054_UPF1_chr19_18976098_ENST00000599848_length(amino acids)=367AA_BP=43
MPRPAPDFVGEGDARLPPLTSPAARSAWERRRSRPAEMEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGAL
YSGLMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKR
EGEELIQAEARCLVETFQGTEGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAGRGTPKGKTGRGGRQ
KNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISMSQPSQMSQPGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CYP2S1-UPF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CYP2S1-UPF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CYP2S1-UPF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCYP2S1C0030246Pustulosis of Palms and Soles1CTD_human
HgeneCYP2S1C0033860Psoriasis1CTD_human