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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GUK1-ARF1 (FusionGDB2 ID:HG2987TG375)

Fusion Gene Summary for GUK1-ARF1

check button Fusion gene summary
Fusion gene informationFusion gene name: GUK1-ARF1
Fusion gene ID: hg2987tg375
HgeneTgene
Gene symbol

GUK1

ARF1

Gene ID

2987

375

Gene nameguanylate kinase 1ADP ribosylation factor 1
SynonymsGMKPVNH8
Cytomap('GUK1')('ARF1')

1q42.13

1q42.13

Type of geneprotein-codingprotein-coding
Descriptionguanylate kinaseATP:GMP phosphotransferaseGMP kinaseADP-ribosylation factor 1
Modification date2020032020200322
UniProtAcc.

P84077

Ensembl transtripts involved in fusion geneENST00000470040, ENST00000312726, 
ENST00000366716, ENST00000366718, 
ENST00000366721, ENST00000366722, 
ENST00000366723, ENST00000366726, 
ENST00000366728, ENST00000366730, 
ENST00000391865, 
ENST00000470040, 
ENST00000312726, ENST00000366716, 
ENST00000366718, ENST00000366721, 
ENST00000366722, ENST00000366723, 
ENST00000366726, ENST00000366728, 
ENST00000366730, ENST00000391865, 
Fusion gene scores* DoF score14 X 13 X 6=10929 X 10 X 6=540
# samples 1611
** MAII scorelog2(16/1092*10)=-2.77082904603249
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/540*10)=-2.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GUK1 [Title/Abstract] AND ARF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGUK1(228328064)-ARF1(228284778), # samples:1
GUK1(228334639)-ARF1(228285553), # samples:1
GUK1(228334638)-ARF1(228285552), # samples:1
Anticipated loss of major functional domain due to fusion event.GUK1-ARF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GUK1-ARF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GUK1-ARF1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GUK1-ARF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GUK1-ARF1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GUK1-ARF1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGUK1

GO:0006163

purine nucleotide metabolic process

8663313

HgeneGUK1

GO:0006805

xenobiotic metabolic process

6306664


check buttonFusion gene breakpoints across GUK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ARF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-EQ-8122GUK1chr1

228328064

+ARF1chr1

228284778

+
ChimerDB4UCECTCGA-EY-A54A-01AGUK1chr1

228334638

+ARF1chr1

228285552

+
ChimerDB4UCECTCGA-EY-A54A-01AGUK1chr1

228334639

+ARF1chr1

228285553

+


Top

Fusion Gene ORF analysis for GUK1-ARF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000470040ENST00000272102GUK1chr1

228334638

+ARF1chr1

228285552

+
3UTR-3CDSENST00000470040ENST00000272102GUK1chr1

228334639

+ARF1chr1

228285553

+
3UTR-3CDSENST00000470040ENST00000540651GUK1chr1

228334638

+ARF1chr1

228285552

+
3UTR-3CDSENST00000470040ENST00000540651GUK1chr1

228334639

+ARF1chr1

228285553

+
3UTR-3UTRENST00000470040ENST00000478424GUK1chr1

228334638

+ARF1chr1

228285552

+
3UTR-3UTRENST00000470040ENST00000478424GUK1chr1

228334639

+ARF1chr1

228285553

+
3UTR-3UTRENST00000470040ENST00000541182GUK1chr1

228334638

+ARF1chr1

228285552

+
3UTR-3UTRENST00000470040ENST00000541182GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000312726ENST00000478424GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000312726ENST00000478424GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000312726ENST00000541182GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000312726ENST00000541182GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366716ENST00000478424GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366716ENST00000478424GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366716ENST00000541182GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366716ENST00000541182GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366718ENST00000478424GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366718ENST00000478424GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366718ENST00000541182GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366718ENST00000541182GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366721ENST00000478424GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366721ENST00000478424GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366721ENST00000541182GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366721ENST00000541182GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366722ENST00000478424GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366722ENST00000478424GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366722ENST00000541182GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366722ENST00000541182GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366723ENST00000478424GUK1chr1

228328064

+ARF1chr1

228284778

+
5CDS-3UTRENST00000366723ENST00000478424GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366723ENST00000478424GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366723ENST00000541182GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366723ENST00000541182GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366726ENST00000478424GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366726ENST00000478424GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366726ENST00000541182GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366726ENST00000541182GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366728ENST00000478424GUK1chr1

228328064

+ARF1chr1

228284778

+
5CDS-3UTRENST00000366728ENST00000478424GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366728ENST00000478424GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366728ENST00000541182GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366728ENST00000541182GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366730ENST00000478424GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366730ENST00000478424GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000366730ENST00000541182GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000366730ENST00000541182GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000391865ENST00000478424GUK1chr1

228328064

+ARF1chr1

228284778

+
5CDS-3UTRENST00000391865ENST00000478424GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000391865ENST00000478424GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-3UTRENST00000391865ENST00000541182GUK1chr1

228334638

+ARF1chr1

228285552

+
5CDS-3UTRENST00000391865ENST00000541182GUK1chr1

228334639

+ARF1chr1

228285553

+
5CDS-5UTRENST00000366723ENST00000272102GUK1chr1

228328064

+ARF1chr1

228284778

+
5CDS-5UTRENST00000366723ENST00000540651GUK1chr1

228328064

+ARF1chr1

228284778

+
5CDS-5UTRENST00000366723ENST00000541182GUK1chr1

228328064

+ARF1chr1

228284778

+
5CDS-5UTRENST00000366728ENST00000272102GUK1chr1

228328064

+ARF1chr1

228284778

+
5CDS-5UTRENST00000366728ENST00000540651GUK1chr1

228328064

+ARF1chr1

228284778

+
5CDS-5UTRENST00000366728ENST00000541182GUK1chr1

228328064

+ARF1chr1

228284778

+
5CDS-5UTRENST00000391865ENST00000272102GUK1chr1

228328064

+ARF1chr1

228284778

+
5CDS-5UTRENST00000391865ENST00000540651GUK1chr1

228328064

+ARF1chr1

228284778

+
5CDS-5UTRENST00000391865ENST00000541182GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-3UTRENST00000312726ENST00000478424GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-3UTRENST00000366721ENST00000478424GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-3UTRENST00000366722ENST00000478424GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-3UTRENST00000366726ENST00000478424GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-5UTRENST00000312726ENST00000272102GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-5UTRENST00000312726ENST00000540651GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-5UTRENST00000312726ENST00000541182GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-5UTRENST00000366721ENST00000272102GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-5UTRENST00000366721ENST00000540651GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-5UTRENST00000366721ENST00000541182GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-5UTRENST00000366722ENST00000272102GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-5UTRENST00000366722ENST00000540651GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-5UTRENST00000366722ENST00000541182GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-5UTRENST00000366726ENST00000272102GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-5UTRENST00000366726ENST00000540651GUK1chr1

228328064

+ARF1chr1

228284778

+
5UTR-5UTRENST00000366726ENST00000541182GUK1chr1

228328064

+ARF1chr1

228284778

+
Frame-shiftENST00000312726ENST00000272102GUK1chr1

228334638

+ARF1chr1

228285552

+
Frame-shiftENST00000312726ENST00000272102GUK1chr1

228334639

+ARF1chr1

228285553

+
Frame-shiftENST00000366716ENST00000272102GUK1chr1

228334638

+ARF1chr1

228285552

+
Frame-shiftENST00000366716ENST00000272102GUK1chr1

228334639

+ARF1chr1

228285553

+
Frame-shiftENST00000366718ENST00000272102GUK1chr1

228334638

+ARF1chr1

228285552

+
Frame-shiftENST00000366718ENST00000272102GUK1chr1

228334639

+ARF1chr1

228285553

+
Frame-shiftENST00000366721ENST00000272102GUK1chr1

228334638

+ARF1chr1

228285552

+
Frame-shiftENST00000366721ENST00000272102GUK1chr1

228334639

+ARF1chr1

228285553

+
Frame-shiftENST00000366722ENST00000272102GUK1chr1

228334638

+ARF1chr1

228285552

+
Frame-shiftENST00000366722ENST00000272102GUK1chr1

228334639

+ARF1chr1

228285553

+
Frame-shiftENST00000366723ENST00000272102GUK1chr1

228334638

+ARF1chr1

228285552

+
Frame-shiftENST00000366723ENST00000272102GUK1chr1

228334639

+ARF1chr1

228285553

+
Frame-shiftENST00000366726ENST00000272102GUK1chr1

228334638

+ARF1chr1

228285552

+
Frame-shiftENST00000366726ENST00000272102GUK1chr1

228334639

+ARF1chr1

228285553

+
Frame-shiftENST00000366728ENST00000272102GUK1chr1

228334638

+ARF1chr1

228285552

+
Frame-shiftENST00000366728ENST00000272102GUK1chr1

228334639

+ARF1chr1

228285553

+
Frame-shiftENST00000366730ENST00000272102GUK1chr1

228334638

+ARF1chr1

228285552

+
Frame-shiftENST00000366730ENST00000272102GUK1chr1

228334639

+ARF1chr1

228285553

+
Frame-shiftENST00000391865ENST00000272102GUK1chr1

228334638

+ARF1chr1

228285552

+
Frame-shiftENST00000391865ENST00000272102GUK1chr1

228334639

+ARF1chr1

228285553

+
In-frameENST00000312726ENST00000540651GUK1chr1

228334638

+ARF1chr1

228285552

+
In-frameENST00000312726ENST00000540651GUK1chr1

228334639

+ARF1chr1

228285553

+
In-frameENST00000366716ENST00000540651GUK1chr1

228334638

+ARF1chr1

228285552

+
In-frameENST00000366716ENST00000540651GUK1chr1

228334639

+ARF1chr1

228285553

+
In-frameENST00000366718ENST00000540651GUK1chr1

228334638

+ARF1chr1

228285552

+
In-frameENST00000366718ENST00000540651GUK1chr1

228334639

+ARF1chr1

228285553

+
In-frameENST00000366721ENST00000540651GUK1chr1

228334638

+ARF1chr1

228285552

+
In-frameENST00000366721ENST00000540651GUK1chr1

228334639

+ARF1chr1

228285553

+
In-frameENST00000366722ENST00000540651GUK1chr1

228334638

+ARF1chr1

228285552

+
In-frameENST00000366722ENST00000540651GUK1chr1

228334639

+ARF1chr1

228285553

+
In-frameENST00000366723ENST00000540651GUK1chr1

228334638

+ARF1chr1

228285552

+
In-frameENST00000366723ENST00000540651GUK1chr1

228334639

+ARF1chr1

228285553

+
In-frameENST00000366726ENST00000540651GUK1chr1

228334638

+ARF1chr1

228285552

+
In-frameENST00000366726ENST00000540651GUK1chr1

228334639

+ARF1chr1

228285553

+
In-frameENST00000366728ENST00000540651GUK1chr1

228334638

+ARF1chr1

228285552

+
In-frameENST00000366728ENST00000540651GUK1chr1

228334639

+ARF1chr1

228285553

+
In-frameENST00000366730ENST00000540651GUK1chr1

228334638

+ARF1chr1

228285552

+
In-frameENST00000366730ENST00000540651GUK1chr1

228334639

+ARF1chr1

228285553

+
In-frameENST00000391865ENST00000540651GUK1chr1

228334638

+ARF1chr1

228285552

+
In-frameENST00000391865ENST00000540651GUK1chr1

228334639

+ARF1chr1

228285553

+
intron-3UTRENST00000366716ENST00000478424GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-3UTRENST00000366718ENST00000478424GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-3UTRENST00000366730ENST00000478424GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-3UTRENST00000470040ENST00000478424GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-5UTRENST00000366716ENST00000272102GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-5UTRENST00000366716ENST00000540651GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-5UTRENST00000366716ENST00000541182GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-5UTRENST00000366718ENST00000272102GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-5UTRENST00000366718ENST00000540651GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-5UTRENST00000366718ENST00000541182GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-5UTRENST00000366730ENST00000272102GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-5UTRENST00000366730ENST00000540651GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-5UTRENST00000366730ENST00000541182GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-5UTRENST00000470040ENST00000272102GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-5UTRENST00000470040ENST00000540651GUK1chr1

228328064

+ARF1chr1

228284778

+
intron-5UTRENST00000470040ENST00000541182GUK1chr1

228328064

+ARF1chr1

228284778

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for GUK1-ARF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GUK1chr1228334639+ARF1chr1228285552+0.377320050.62267995
GUK1chr1228328064+ARF1chr1228284778+1.76E-050.99998236
GUK1chr1228334639+ARF1chr1228285552+0.377320050.62267995
GUK1chr1228328064+ARF1chr1228284778+1.76E-050.99998236

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GUK1-ARF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:228328064/chr1:228284778)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARF1

P84077

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGUK1chr1:228334638chr1:228285552ENST00000312726+5914_1983198.0Nucleotide bindingATP
HgeneGUK1chr1:228334638chr1:228285552ENST00000312726+5937_5183198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228334638chr1:228285552ENST00000366716+3714_1983198.0Nucleotide bindingATP
HgeneGUK1chr1:228334638chr1:228285552ENST00000366716+3737_5183198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228334638chr1:228285552ENST00000366718+4814_1983198.0Nucleotide bindingATP
HgeneGUK1chr1:228334638chr1:228285552ENST00000366718+4837_5183198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228334638chr1:228285552ENST00000366726+4814_1983198.0Nucleotide bindingATP
HgeneGUK1chr1:228334638chr1:228285552ENST00000366726+4837_5183198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228334638chr1:228285552ENST00000366728+4714_19104242.0Nucleotide bindingATP
HgeneGUK1chr1:228334638chr1:228285552ENST00000366728+4737_51104242.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228334638chr1:228285552ENST00000366730+4814_1983198.0Nucleotide bindingATP
HgeneGUK1chr1:228334638chr1:228285552ENST00000366730+4837_5183198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228334638chr1:228285552ENST00000391865+4814_19104219.0Nucleotide bindingATP
HgeneGUK1chr1:228334638chr1:228285552ENST00000391865+4837_51104219.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228334639chr1:228285553ENST00000312726+5914_1983198.0Nucleotide bindingATP
HgeneGUK1chr1:228334639chr1:228285553ENST00000312726+5937_5183198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228334639chr1:228285553ENST00000366716+3714_1983198.0Nucleotide bindingATP
HgeneGUK1chr1:228334639chr1:228285553ENST00000366716+3737_5183198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228334639chr1:228285553ENST00000366718+4814_1983198.0Nucleotide bindingATP
HgeneGUK1chr1:228334639chr1:228285553ENST00000366718+4837_5183198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228334639chr1:228285553ENST00000366726+4814_1983198.0Nucleotide bindingATP
HgeneGUK1chr1:228334639chr1:228285553ENST00000366726+4837_5183198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228334639chr1:228285553ENST00000366728+4714_19104242.0Nucleotide bindingATP
HgeneGUK1chr1:228334639chr1:228285553ENST00000366728+4737_51104242.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228334639chr1:228285553ENST00000366730+4814_1983198.0Nucleotide bindingATP
HgeneGUK1chr1:228334639chr1:228285553ENST00000366730+4837_5183198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228334639chr1:228285553ENST00000391865+4814_19104219.0Nucleotide bindingATP
HgeneGUK1chr1:228334639chr1:228285553ENST00000391865+4837_51104219.0Nucleotide bindingSubstrate binding
TgeneARF1chr1:228334638chr1:228285552ENST0000027210235126_129128182.0Nucleotide bindingGTP
TgeneARF1chr1:228334638chr1:228285552ENST0000054065135126_129128182.0Nucleotide bindingGTP
TgeneARF1chr1:228334638chr1:228285552ENST0000054118235126_129128182.0Nucleotide bindingGTP
TgeneARF1chr1:228334639chr1:228285553ENST0000027210235126_129128182.0Nucleotide bindingGTP
TgeneARF1chr1:228334639chr1:228285553ENST0000054065135126_129128182.0Nucleotide bindingGTP
TgeneARF1chr1:228334639chr1:228285553ENST0000054118235126_129128182.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGUK1chr1:228334638chr1:228285552ENST00000312726+594_18683198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228334638chr1:228285552ENST00000366716+374_18683198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228334638chr1:228285552ENST00000366718+484_18683198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228334638chr1:228285552ENST00000366726+484_18683198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228334638chr1:228285552ENST00000366728+474_186104242.0DomainGuanylate kinase-like
HgeneGUK1chr1:228334638chr1:228285552ENST00000366730+484_18683198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228334638chr1:228285552ENST00000391865+484_186104219.0DomainGuanylate kinase-like
HgeneGUK1chr1:228334639chr1:228285553ENST00000312726+594_18683198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228334639chr1:228285553ENST00000366716+374_18683198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228334639chr1:228285553ENST00000366718+484_18683198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228334639chr1:228285553ENST00000366726+484_18683198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228334639chr1:228285553ENST00000366728+474_186104242.0DomainGuanylate kinase-like
HgeneGUK1chr1:228334639chr1:228285553ENST00000366730+484_18683198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228334639chr1:228285553ENST00000391865+484_186104219.0DomainGuanylate kinase-like
HgeneGUK1chr1:228334638chr1:228285552ENST00000312726+59171_17283198.0Nucleotide bindingATP
HgeneGUK1chr1:228334638chr1:228285552ENST00000366716+37171_17283198.0Nucleotide bindingATP
HgeneGUK1chr1:228334638chr1:228285552ENST00000366718+48171_17283198.0Nucleotide bindingATP
HgeneGUK1chr1:228334638chr1:228285552ENST00000366726+48171_17283198.0Nucleotide bindingATP
HgeneGUK1chr1:228334638chr1:228285552ENST00000366728+47171_172104242.0Nucleotide bindingATP
HgeneGUK1chr1:228334638chr1:228285552ENST00000366730+48171_17283198.0Nucleotide bindingATP
HgeneGUK1chr1:228334638chr1:228285552ENST00000391865+48171_172104219.0Nucleotide bindingATP
HgeneGUK1chr1:228334639chr1:228285553ENST00000312726+59171_17283198.0Nucleotide bindingATP
HgeneGUK1chr1:228334639chr1:228285553ENST00000366716+37171_17283198.0Nucleotide bindingATP
HgeneGUK1chr1:228334639chr1:228285553ENST00000366718+48171_17283198.0Nucleotide bindingATP
HgeneGUK1chr1:228334639chr1:228285553ENST00000366726+48171_17283198.0Nucleotide bindingATP
HgeneGUK1chr1:228334639chr1:228285553ENST00000366728+47171_172104242.0Nucleotide bindingATP
HgeneGUK1chr1:228334639chr1:228285553ENST00000366730+48171_17283198.0Nucleotide bindingATP
HgeneGUK1chr1:228334639chr1:228285553ENST00000391865+48171_172104219.0Nucleotide bindingATP
TgeneARF1chr1:228334638chr1:228285552ENST000002721023524_32128182.0Nucleotide bindingGTP
TgeneARF1chr1:228334638chr1:228285552ENST000005406513524_32128182.0Nucleotide bindingGTP
TgeneARF1chr1:228334638chr1:228285552ENST000005411823524_32128182.0Nucleotide bindingGTP
TgeneARF1chr1:228334639chr1:228285553ENST000002721023524_32128182.0Nucleotide bindingGTP
TgeneARF1chr1:228334639chr1:228285553ENST000005406513524_32128182.0Nucleotide bindingGTP
TgeneARF1chr1:228334639chr1:228285553ENST000005411823524_32128182.0Nucleotide bindingGTP


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Fusion Gene Sequence for GUK1-ARF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GUK1-ARF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GUK1-ARF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneARF1P84077DB09462GlycerinSmall moleculeApproved|Investigational

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Related Diseases for GUK1-ARF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0027626Neoplasm Invasiveness1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1868720Periventricular Nodular Heterotopia1ORPHANET
TgeneC4704874Mammary Carcinoma, Human1CTD_human
TgeneC4748602PERIVENTRICULAR NODULAR HETEROTOPIA 81UNIPROT