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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALG6-SLC22A15 (FusionGDB2 ID:HG29929TG55356)

Fusion Gene Summary for ALG6-SLC22A15

check button Fusion gene summary
Fusion gene informationFusion gene name: ALG6-SLC22A15
Fusion gene ID: hg29929tg55356
HgeneTgene
Gene symbol

ALG6

SLC22A15

Gene ID

29929

55356

Gene nameALG6 alpha-1,3-glucosyltransferasesolute carrier family 22 member 15
SynonymsCDG1CFLIPT1|PRO34686
Cytomap('ALG6')('SLC22A15')

1p31.3

1p13.1

Type of geneprotein-codingprotein-coding
Descriptiondolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferaseMan(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferaseasparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)asparagine-linked glycosylation 6 homolog (yeastsolute carrier family 22 member 15flipt 1fly-like putative organic ion transporter 1fly-like putative transporter 1solute carrier family 22 (organic cation transporter), member 15trans-like protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263440, ENST00000371108, 
ENST00000494765, 
Fusion gene scores* DoF score10 X 8 X 6=4805 X 4 X 4=80
# samples 105
** MAII scorelog2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALG6 [Title/Abstract] AND SLC22A15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALG6(63836730)-SLC22A15(116569514), # samples:1
Anticipated loss of major functional domain due to fusion event.ALG6-SLC22A15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ALG6-SLC22A15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALG6

GO:0006487

protein N-linked glycosylation

10924277


check buttonFusion gene breakpoints across ALG6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SLC22A15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A44R-06AALG6chr1

63836730

-SLC22A15chr1

116569514

+


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Fusion Gene ORF analysis for ALG6-SLC22A15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263440ENST00000481127ALG6chr1

63836730

-SLC22A15chr1

116569514

+
5CDS-intronENST00000371108ENST00000481127ALG6chr1

63836730

-SLC22A15chr1

116569514

+
In-frameENST00000263440ENST00000369502ALG6chr1

63836730

-SLC22A15chr1

116569514

+
In-frameENST00000263440ENST00000369503ALG6chr1

63836730

-SLC22A15chr1

116569514

+
In-frameENST00000371108ENST00000369502ALG6chr1

63836730

-SLC22A15chr1

116569514

+
In-frameENST00000371108ENST00000369503ALG6chr1

63836730

-SLC22A15chr1

116569514

+
intron-3CDSENST00000494765ENST00000369502ALG6chr1

63836730

-SLC22A15chr1

116569514

+
intron-3CDSENST00000494765ENST00000369503ALG6chr1

63836730

-SLC22A15chr1

116569514

+
intron-intronENST00000494765ENST00000481127ALG6chr1

63836730

-SLC22A15chr1

116569514

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371108ALG6chr163836730-ENST00000369503SLC22A15chr1116569514+43793873051432375
ENST00000371108ALG6chr163836730-ENST00000369502SLC22A15chr1116569514+100538730552673
ENST00000263440ALG6chr163836730-ENST00000369503SLC22A15chr1116569514+42822902081335375
ENST00000263440ALG6chr163836730-ENST00000369502SLC22A15chr1116569514+90829020842973

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371108ENST00000369503ALG6chr163836730-SLC22A15chr1116569514+0.0031863370.9968137
ENST00000371108ENST00000369502ALG6chr163836730-SLC22A15chr1116569514+0.15476540.84523463
ENST00000263440ENST00000369503ALG6chr163836730-SLC22A15chr1116569514+0.0032979080.99670213
ENST00000263440ENST00000369502ALG6chr163836730-SLC22A15chr1116569514+0.213815180.78618485

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Fusion Genomic Features for ALG6-SLC22A15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ALG6-SLC22A15


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:63836730/chr1:116569514)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALG6chr1:63836730chr1:116569514ENST00000371108-2154_2427508.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST0000036950236529_535199246.0Compositional biasNote=Poly-Glu
TgeneSLC22A15chr1:63836730chr1:116569514ENST00000369503312529_535199548.0Compositional biasNote=Poly-Glu
TgeneSLC22A15chr1:63836730chr1:116569514ENST0000036950236201_221199246.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST0000036950236226_246199246.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST0000036950236303_323199246.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST0000036950236338_358199246.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST0000036950236368_388199246.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST0000036950236401_420199246.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST0000036950236433_453199246.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST0000036950236462_482199246.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST00000369503312201_221199548.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST00000369503312226_246199548.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST00000369503312303_323199548.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST00000369503312338_358199548.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST00000369503312368_388199548.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST00000369503312401_420199548.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST00000369503312433_453199548.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST00000369503312462_482199548.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALG6chr1:63836730chr1:116569514ENST00000371108-215115_13527508.0TransmembraneHelical
HgeneALG6chr1:63836730chr1:116569514ENST00000371108-215144_16427508.0TransmembraneHelical
HgeneALG6chr1:63836730chr1:116569514ENST00000371108-215173_19327508.0TransmembraneHelical
HgeneALG6chr1:63836730chr1:116569514ENST00000371108-215227_24727508.0TransmembraneHelical
HgeneALG6chr1:63836730chr1:116569514ENST00000371108-215298_31827508.0TransmembraneHelical
HgeneALG6chr1:63836730chr1:116569514ENST00000371108-215324_34427508.0TransmembraneHelical
HgeneALG6chr1:63836730chr1:116569514ENST00000371108-215362_38227508.0TransmembraneHelical
HgeneALG6chr1:63836730chr1:116569514ENST00000371108-215388_40827508.0TransmembraneHelical
HgeneALG6chr1:63836730chr1:116569514ENST00000371108-215438_45827508.0TransmembraneHelical
HgeneALG6chr1:63836730chr1:116569514ENST00000371108-215473_49327508.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST0000036950236111_131199246.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST0000036950236141_161199246.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST0000036950236165_187199246.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST000003695023622_42199246.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST00000369503312111_131199548.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST00000369503312141_161199548.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST00000369503312165_187199548.0TransmembraneHelical
TgeneSLC22A15chr1:63836730chr1:116569514ENST0000036950331222_42199548.0TransmembraneHelical


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Fusion Gene Sequence for ALG6-SLC22A15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4032_4032_1_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000263440_SLC22A15_chr1_116569514_ENST00000369502_length(transcript)=908nt_BP=290nt
GGATACTTCTACATAGACATAATCAAGTTTTGACTATTTGGAAACCAAGCATCATTAAAATTCTCTCAAACTCCTAATTGCGAAGAATCG
ATAACATTTCAAGAAGTGATAACATTTCTCTGAACAAGAAAAGAAGTGATTGACCACGTTTTAAAAGTACTCTGGCACTGGTGCTGTGTT
TTCTTCCCCTCCCTAAATTTGAAGAACTATGGAGAAATGGTACTTGATGACAGTAGTGGTTTTAATAGGACTAACAGTACGATGGACAGT
GTCTCTTAATTCTTATTCAGGATCGATTGGCGGCCTGTTCTTTGCAGTTGGCATTGCCCAATATGCCCTGTTAGGATACTTCATCCGCTC
CTGGAGGACCCTAGCCATTCTGGTTAACCTGCAGGGAACGGTGGTCTTTCTCTTATCTTTGGTCGACTGAGTGAGGCTGAAGAGGCGCTG
TACCTCATTGCCAAGAGGAACCGCAAACTCAAGTGCACGTTCTCACTAACACACCCAGCCAACAGGAGCTGCAGGGAGACTGGAAGTTTC
CTGGATCTCTTTCGTTACCGGGTCCTGTTAGGACACACTTTGATCCTGATGTTCATCTGGTAATTATACTAAGGCGTGTTCTGTTGCTCT
TTAACTAAGGTTGCTCGAGCTTCTCTTGATATCCTGCTCCTTCTTCAGGGTACAGGGAATTTTACCTCTTTTGTTAGCTTGAGGTTGTTT
TCTCAACAGCAAGTCTCCTGATCCTTAGCGCCTGGTTTTCTGCTTGCGCAGCCCCGTCTTTCTCAAGTAGCAGATGATAGTGCCTGATGG
GCAGGTCCACTGAGCTTGAGTAAGTAGACATCAGAAGCACATCTTTGCTTTTGAGGTATTTATCATAAATATTTAAGCCTTCCTGCCCCT
TCCCCTGC

>4032_4032_1_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000263440_SLC22A15_chr1_116569514_ENST00000369502_length(amino acids)=73AA_BP=21
MEKWYLMTVVVLIGLTVRWTVSLNSYSGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLVD

--------------------------------------------------------------
>4032_4032_2_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000263440_SLC22A15_chr1_116569514_ENST00000369503_length(transcript)=4282nt_BP=290nt
GGATACTTCTACATAGACATAATCAAGTTTTGACTATTTGGAAACCAAGCATCATTAAAATTCTCTCAAACTCCTAATTGCGAAGAATCG
ATAACATTTCAAGAAGTGATAACATTTCTCTGAACAAGAAAAGAAGTGATTGACCACGTTTTAAAAGTACTCTGGCACTGGTGCTGTGTT
TTCTTCCCCTCCCTAAATTTGAAGAACTATGGAGAAATGGTACTTGATGACAGTAGTGGTTTTAATAGGACTAACAGTACGATGGACAGT
GTCTCTTAATTCTTATTCAGGATCGATTGGCGGCCTGTTCTTTGCAGTTGGCATTGCCCAATATGCCCTGTTAGGATACTTCATCCGCTC
CTGGAGGACCCTAGCCATTCTGGTTAACCTGCAGGGAACGGTGGTCTTTCTCTTATCTTTATTCATTCCTGAATCACCTCGTTGGTTATA
CTCCCAGGGTCGACTGAGTGAGGCTGAAGAGGCGCTGTACCTCATTGCCAAGAGGAACCGCAAACTCAAGTGCACGTTCTCACTAACACA
CCCAGCCAACAGGAGCTGCAGGGAGACTGGAAGTTTCCTGGATCTCTTTCGTTACCGGGTCCTGTTAGGACACACTTTGATCCTGATGTT
CATCTGGTTTGTGTGCAGCTTGGTGTATTATGGCCTAACTCTGAGTGCGGGTGATCTAGGTGGAAGTATTTATGCCAACCTGGCCCTGTC
TGGCCTCATAGAGATTCCATCTTACCCTCTCTGTATCTACTTGATTAACCAAAAATGGTTTGGTCGGAAGCGAACATTATCAGCATTTCT
GTGCCTAGGAGGACTGGCTTGTCTTATTGTAATGTTTCTTCCAGAAAAGAAAGACACAGGTGTGTTTGCAGTGGTGAACAGCCATTCCTT
GTCCTTGCTGGGGAAGCTGACCATCAGTGCTGCCTTTAACATTGTTTATATCTACACCTCTGAGCTTTACCCTACAGTCATCAGGAATGT
TGGGCTTGGAACTTGTTCCATGTTCTCCCGAGTTGGTGGGATTATTGCTCCCTTCATCCCCTCACTGAAATATGTGCAATGGTCTTTACC
ATTCATTGTCTTCGGAGCCACGGGTCTGACCTCCGGCCTCCTGAGTTTGTTATTGCCGGAGACCCTTAACAGTCCGCTGCTAGAAACATT
CTCCGACCTTCAGGTGTATTCGTATCGCAGGCTGGGAGAAGAAGCATTATCTTTACAGGCTTTGGACCCCCAACAGTGTGTGGACAAGGA
GAGCTCTTTAGGGAGTGAGAGTGAGGAAGAGGAAGAATTTTATGATGCAGATGAAGAGACTCAGATGATCAAGTGAAGAGCCCCAGATTC
CCCCTAAGAAGCAAAGGATCGTCTTTTATGCCTCTGGCTAAGGCAGGTTCTTCCATGACTCCTAAGAGAGTTGTAAAAATAGAGGCTTGG
CTTGAATGTACATAGATGGTACCTGGCATGGACTGATGTTTTTAGGCACAGAAGTTGGAGAAGAGATTTCATGAAAGACAACATCACTGC
ATTGAGAGAATAGTTGTTAATTTGTTTAGAATTTAAGTTCTACTCAGAATCATAACATCTGGCAGAACAGCCCAAACCCACATTCCAAAG
TGGTAGGCTCATTTGTTTCTAGAGATTTCATCATGTCGCTTTTCCTTCATCATGATCTAAATAAAGGCAGATATGTAAAATTTCTCACCA
TTTTGGTGGGGTAAGATAAGCTATTATTAAGATTTAATCCTTATACCATGTTGGACATTTGCCCCTATCAGTTGCTCCTCAGGAATCTTC
TGGTACAGGTTAACATCAGCATTTTCATTTTGTGTCCAGGGAAAAGCACCCAGAGGTCATCTGTGTGTCCCGAGACCCTCCAGCTTTTTC
TTAGCTGATGAAATATGAGTCCTCAGCTTGGTTCCCAGCCTGCTGATTGACTTGGGCTGCTGGTGCCTTGAGTCCCACAGATGATTCATT
AGGAAAAGCCAGATATACCAAAGCGGTTTACTCAGAGTCAGGGGTGTAGCTCTGGCTGCCTGTCAGCTCCCTTGGATACTATATTGTATG
ATTTCTTCCTTTCCCACTAATATGCACATCCAGAAAAATTTCCATCTGAGATTCTAGTACTTCAAAATCATGCATAGTAAATGAGAAAGC
TTTAAGTAGAGGGCAGTTAAACAGTGACATGTTGAGCACCTGGAGGAAAAAAAAGGTGCAGTTTTTAATAAGAGAGAAAATGAAATTATC
TTTGATAAATTTTTGTTTGTTTTGCTTTCAGCATTGTGCCATGAGGGATTTGGACAATATTTAAGAACTTCTTGTCCTAGATCAGCCCCA
ATCTGTTTAATCAAAATGGAAGGTTCAGTAATTTCATGGGAAACCTTGGTTTTTCATTAAGTGCTACCAACTTTCAAGTGAATCTTGTAT
TTGATTTCCTAAAATCATGTCTTGAAAACATGTTTTCTCATGAAACTTGAATACTATCTCAAATAGGAATATAAACCTGGAGTCAACAAG
CTTAGGCAGCATTGATTTAGGTCACTTTCCCAGTGAGGAAAATTTCTGTGTTTTCAGAATTTCCATTTCTACTAACCTCTTGGAGAAAAA
GAAATTGAATTAGAGGTAAATAGAAGACGTCACTGTGGCTGCTTCTGGAAGTGCTGGAAGCATCACCCCAATTGGCTCCAAATACTGTCA
TGTTTTCTTGCACACTGACTTCTGGTTTCCACTGTATCAGTATGTACCTTTGTAATTGTTATTTTTATGTCTTTTATGCCCTTGATTATT
AGTTGGGCTCTTCATAAACAGAGGCCATCTCTACTACTGTTTATTTTTCCCTGCTGTGCCCAGAACATTGGCGTAGACACAGTAAGAACC
TAGTAAATATTACTGTTTCTAGCCATCAGGGAGATTGTGGAACTCCTCCCAGTATAATTTTTACAAACTCCAAGCAAATCTGACCCAAAC
TCCCAAATTGTCAAGTCCTGCTTAACTTTCTCTGGAAAATAGACCCCTTCTCAACATCAGAATAGGAAGAGAGGAAGAACTTACAAAGAC
ACTTAAAAGTTATTCTTAAATGGTGGTTGGGCATTTAAAACAGTGAACTAACATATATATAATTTTTGATTAGTTGGAGCTTTCTTTGTA
TTATAAGAGTAATATATCTCATTACAGAAAATTTGGAAACTATAAATTTAGAAACGTATCACCCATACGTCCAACATCGAAAGAAAACCA
GTGTTATGACTTTGTTCCATTTGAAGACTAATTGGGAGTCCATCTCTCTATTGGCACTGGGTTCGATTGCCTCTGGCTAATAGAGTTCAA
TTAGTTCTATCCCTGGGTTTCCTTTCTTAGCTATGGGGTGGAAGATAGGAGGGGGAGATCTACAATTTGAATATGTGTTACTTAATAAGG
CTAGGCTGGCCATCAGTTGCTTATTTCAGATGTGTCACTAAATTTTCCTTCTAGATGGTCCTTGAGCAAAACTTAATAATTACTGTTTTT
TATTTCCACTGCCTTTATAAAATCAAAATTTTCTCCTTTTGATAAAAACTGTTGAATACTATTGATGTAGAGAATGTGTATATGTGTATA
TTTGCATTGATTAAATTATTGGAAAACTTTTCATTGACAGGTAATGTATTTTGGTTGTGCGGATGGTTTGTAAAAAGTATCCTGTTTTTT
TAATTCTATTCAAAATTAAAAATTTTTTTTCCTAAAATAAAGCAAGAAAAATAAATGTAAGATATATAAGAAACCCCAGAGTTTCCAGGG
TGAAAGTTCACATTAGCAGCTTGTCCAAAATATTTACACCTCACAAATATTTTGAAAGAAACCATGTTGAAATTTTCTGATTTTGTGAGT
TACAACCACAGCCCAGTAAAACCAATACTTGTTATTTGGCTACTTTCAAGCAATGCAGATATTCTTTAGTATTTAAAAATGAGCAAATAA
ACAAAATGAGGCAAATAAATGAAGAAAATGAGTTTCTGAGACACTGTTTAGGTAACCATAAATCAGACAGATATTTTTATGGTGGGCAAA
TTGATGAAGATACTTTTAGTAGGTGATTTATATTCATAACAAATACATATTGAAATAATTGTCACTACTGTATCAGAATTAAAAACCAGC
TTCACATTAGGACTTCTCCATACAAATGCTTTATCATTGGTTCTTAAATTGGAAAAATATCTATAAATGATTACATTTTTAAGCTAAATA
AAATGCAGATATTTTGGCTTCTTGTGAATGTAATAAAGAATCATAAAACATA

>4032_4032_2_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000263440_SLC22A15_chr1_116569514_ENST00000369503_length(amino acids)=375AA_BP=21
MEKWYLMTVVVLIGLTVRWTVSLNSYSGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAE
EALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYP
LCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFS
RVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEEALSLQALDPQQCVDKESSLGSESEE
EEEFYDADEETQMIK

--------------------------------------------------------------
>4032_4032_3_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000371108_SLC22A15_chr1_116569514_ENST00000369502_length(transcript)=1005nt_BP=387nt
CGGAAGGCCGGAGGGGCAGTCCGCCGCGGGGGCGAGCGCGCATGCGCCTTCCTGGGACCCACGGCAGGCGCGAATCCCAGCGGCCGGCGG
GCGGCGGGGATACTTCTACATAGACATAATCAAGTTTTGACTATTTGGAAACCAAGCATCATTAAAATTCTCTCAAACTCCTAATTGCGA
AGAATCGATAACATTTCAAGAAGTGATAACATTTCTCTGAACAAGAAAAGAAGTGATTGACCACGTTTTAAAAGTACTCTGGCACTGGTG
CTGTGTTTTCTTCCCCTCCCTAAATTTGAAGAACTATGGAGAAATGGTACTTGATGACAGTAGTGGTTTTAATAGGACTAACAGTACGAT
GGACAGTGTCTCTTAATTCTTATTCAGGATCGATTGGCGGCCTGTTCTTTGCAGTTGGCATTGCCCAATATGCCCTGTTAGGATACTTCA
TCCGCTCCTGGAGGACCCTAGCCATTCTGGTTAACCTGCAGGGAACGGTGGTCTTTCTCTTATCTTTGGTCGACTGAGTGAGGCTGAAGA
GGCGCTGTACCTCATTGCCAAGAGGAACCGCAAACTCAAGTGCACGTTCTCACTAACACACCCAGCCAACAGGAGCTGCAGGGAGACTGG
AAGTTTCCTGGATCTCTTTCGTTACCGGGTCCTGTTAGGACACACTTTGATCCTGATGTTCATCTGGTAATTATACTAAGGCGTGTTCTG
TTGCTCTTTAACTAAGGTTGCTCGAGCTTCTCTTGATATCCTGCTCCTTCTTCAGGGTACAGGGAATTTTACCTCTTTTGTTAGCTTGAG
GTTGTTTTCTCAACAGCAAGTCTCCTGATCCTTAGCGCCTGGTTTTCTGCTTGCGCAGCCCCGTCTTTCTCAAGTAGCAGATGATAGTGC
CTGATGGGCAGGTCCACTGAGCTTGAGTAAGTAGACATCAGAAGCACATCTTTGCTTTTGAGGTATTTATCATAAATATTTAAGCCTTCC
TGCCCCTTCCCCTGC

>4032_4032_3_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000371108_SLC22A15_chr1_116569514_ENST00000369502_length(amino acids)=73AA_BP=21
MEKWYLMTVVVLIGLTVRWTVSLNSYSGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLVD

--------------------------------------------------------------
>4032_4032_4_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000371108_SLC22A15_chr1_116569514_ENST00000369503_length(transcript)=4379nt_BP=387nt
CGGAAGGCCGGAGGGGCAGTCCGCCGCGGGGGCGAGCGCGCATGCGCCTTCCTGGGACCCACGGCAGGCGCGAATCCCAGCGGCCGGCGG
GCGGCGGGGATACTTCTACATAGACATAATCAAGTTTTGACTATTTGGAAACCAAGCATCATTAAAATTCTCTCAAACTCCTAATTGCGA
AGAATCGATAACATTTCAAGAAGTGATAACATTTCTCTGAACAAGAAAAGAAGTGATTGACCACGTTTTAAAAGTACTCTGGCACTGGTG
CTGTGTTTTCTTCCCCTCCCTAAATTTGAAGAACTATGGAGAAATGGTACTTGATGACAGTAGTGGTTTTAATAGGACTAACAGTACGAT
GGACAGTGTCTCTTAATTCTTATTCAGGATCGATTGGCGGCCTGTTCTTTGCAGTTGGCATTGCCCAATATGCCCTGTTAGGATACTTCA
TCCGCTCCTGGAGGACCCTAGCCATTCTGGTTAACCTGCAGGGAACGGTGGTCTTTCTCTTATCTTTATTCATTCCTGAATCACCTCGTT
GGTTATACTCCCAGGGTCGACTGAGTGAGGCTGAAGAGGCGCTGTACCTCATTGCCAAGAGGAACCGCAAACTCAAGTGCACGTTCTCAC
TAACACACCCAGCCAACAGGAGCTGCAGGGAGACTGGAAGTTTCCTGGATCTCTTTCGTTACCGGGTCCTGTTAGGACACACTTTGATCC
TGATGTTCATCTGGTTTGTGTGCAGCTTGGTGTATTATGGCCTAACTCTGAGTGCGGGTGATCTAGGTGGAAGTATTTATGCCAACCTGG
CCCTGTCTGGCCTCATAGAGATTCCATCTTACCCTCTCTGTATCTACTTGATTAACCAAAAATGGTTTGGTCGGAAGCGAACATTATCAG
CATTTCTGTGCCTAGGAGGACTGGCTTGTCTTATTGTAATGTTTCTTCCAGAAAAGAAAGACACAGGTGTGTTTGCAGTGGTGAACAGCC
ATTCCTTGTCCTTGCTGGGGAAGCTGACCATCAGTGCTGCCTTTAACATTGTTTATATCTACACCTCTGAGCTTTACCCTACAGTCATCA
GGAATGTTGGGCTTGGAACTTGTTCCATGTTCTCCCGAGTTGGTGGGATTATTGCTCCCTTCATCCCCTCACTGAAATATGTGCAATGGT
CTTTACCATTCATTGTCTTCGGAGCCACGGGTCTGACCTCCGGCCTCCTGAGTTTGTTATTGCCGGAGACCCTTAACAGTCCGCTGCTAG
AAACATTCTCCGACCTTCAGGTGTATTCGTATCGCAGGCTGGGAGAAGAAGCATTATCTTTACAGGCTTTGGACCCCCAACAGTGTGTGG
ACAAGGAGAGCTCTTTAGGGAGTGAGAGTGAGGAAGAGGAAGAATTTTATGATGCAGATGAAGAGACTCAGATGATCAAGTGAAGAGCCC
CAGATTCCCCCTAAGAAGCAAAGGATCGTCTTTTATGCCTCTGGCTAAGGCAGGTTCTTCCATGACTCCTAAGAGAGTTGTAAAAATAGA
GGCTTGGCTTGAATGTACATAGATGGTACCTGGCATGGACTGATGTTTTTAGGCACAGAAGTTGGAGAAGAGATTTCATGAAAGACAACA
TCACTGCATTGAGAGAATAGTTGTTAATTTGTTTAGAATTTAAGTTCTACTCAGAATCATAACATCTGGCAGAACAGCCCAAACCCACAT
TCCAAAGTGGTAGGCTCATTTGTTTCTAGAGATTTCATCATGTCGCTTTTCCTTCATCATGATCTAAATAAAGGCAGATATGTAAAATTT
CTCACCATTTTGGTGGGGTAAGATAAGCTATTATTAAGATTTAATCCTTATACCATGTTGGACATTTGCCCCTATCAGTTGCTCCTCAGG
AATCTTCTGGTACAGGTTAACATCAGCATTTTCATTTTGTGTCCAGGGAAAAGCACCCAGAGGTCATCTGTGTGTCCCGAGACCCTCCAG
CTTTTTCTTAGCTGATGAAATATGAGTCCTCAGCTTGGTTCCCAGCCTGCTGATTGACTTGGGCTGCTGGTGCCTTGAGTCCCACAGATG
ATTCATTAGGAAAAGCCAGATATACCAAAGCGGTTTACTCAGAGTCAGGGGTGTAGCTCTGGCTGCCTGTCAGCTCCCTTGGATACTATA
TTGTATGATTTCTTCCTTTCCCACTAATATGCACATCCAGAAAAATTTCCATCTGAGATTCTAGTACTTCAAAATCATGCATAGTAAATG
AGAAAGCTTTAAGTAGAGGGCAGTTAAACAGTGACATGTTGAGCACCTGGAGGAAAAAAAAGGTGCAGTTTTTAATAAGAGAGAAAATGA
AATTATCTTTGATAAATTTTTGTTTGTTTTGCTTTCAGCATTGTGCCATGAGGGATTTGGACAATATTTAAGAACTTCTTGTCCTAGATC
AGCCCCAATCTGTTTAATCAAAATGGAAGGTTCAGTAATTTCATGGGAAACCTTGGTTTTTCATTAAGTGCTACCAACTTTCAAGTGAAT
CTTGTATTTGATTTCCTAAAATCATGTCTTGAAAACATGTTTTCTCATGAAACTTGAATACTATCTCAAATAGGAATATAAACCTGGAGT
CAACAAGCTTAGGCAGCATTGATTTAGGTCACTTTCCCAGTGAGGAAAATTTCTGTGTTTTCAGAATTTCCATTTCTACTAACCTCTTGG
AGAAAAAGAAATTGAATTAGAGGTAAATAGAAGACGTCACTGTGGCTGCTTCTGGAAGTGCTGGAAGCATCACCCCAATTGGCTCCAAAT
ACTGTCATGTTTTCTTGCACACTGACTTCTGGTTTCCACTGTATCAGTATGTACCTTTGTAATTGTTATTTTTATGTCTTTTATGCCCTT
GATTATTAGTTGGGCTCTTCATAAACAGAGGCCATCTCTACTACTGTTTATTTTTCCCTGCTGTGCCCAGAACATTGGCGTAGACACAGT
AAGAACCTAGTAAATATTACTGTTTCTAGCCATCAGGGAGATTGTGGAACTCCTCCCAGTATAATTTTTACAAACTCCAAGCAAATCTGA
CCCAAACTCCCAAATTGTCAAGTCCTGCTTAACTTTCTCTGGAAAATAGACCCCTTCTCAACATCAGAATAGGAAGAGAGGAAGAACTTA
CAAAGACACTTAAAAGTTATTCTTAAATGGTGGTTGGGCATTTAAAACAGTGAACTAACATATATATAATTTTTGATTAGTTGGAGCTTT
CTTTGTATTATAAGAGTAATATATCTCATTACAGAAAATTTGGAAACTATAAATTTAGAAACGTATCACCCATACGTCCAACATCGAAAG
AAAACCAGTGTTATGACTTTGTTCCATTTGAAGACTAATTGGGAGTCCATCTCTCTATTGGCACTGGGTTCGATTGCCTCTGGCTAATAG
AGTTCAATTAGTTCTATCCCTGGGTTTCCTTTCTTAGCTATGGGGTGGAAGATAGGAGGGGGAGATCTACAATTTGAATATGTGTTACTT
AATAAGGCTAGGCTGGCCATCAGTTGCTTATTTCAGATGTGTCACTAAATTTTCCTTCTAGATGGTCCTTGAGCAAAACTTAATAATTAC
TGTTTTTTATTTCCACTGCCTTTATAAAATCAAAATTTTCTCCTTTTGATAAAAACTGTTGAATACTATTGATGTAGAGAATGTGTATAT
GTGTATATTTGCATTGATTAAATTATTGGAAAACTTTTCATTGACAGGTAATGTATTTTGGTTGTGCGGATGGTTTGTAAAAAGTATCCT
GTTTTTTTAATTCTATTCAAAATTAAAAATTTTTTTTCCTAAAATAAAGCAAGAAAAATAAATGTAAGATATATAAGAAACCCCAGAGTT
TCCAGGGTGAAAGTTCACATTAGCAGCTTGTCCAAAATATTTACACCTCACAAATATTTTGAAAGAAACCATGTTGAAATTTTCTGATTT
TGTGAGTTACAACCACAGCCCAGTAAAACCAATACTTGTTATTTGGCTACTTTCAAGCAATGCAGATATTCTTTAGTATTTAAAAATGAG
CAAATAAACAAAATGAGGCAAATAAATGAAGAAAATGAGTTTCTGAGACACTGTTTAGGTAACCATAAATCAGACAGATATTTTTATGGT
GGGCAAATTGATGAAGATACTTTTAGTAGGTGATTTATATTCATAACAAATACATATTGAAATAATTGTCACTACTGTATCAGAATTAAA
AACCAGCTTCACATTAGGACTTCTCCATACAAATGCTTTATCATTGGTTCTTAAATTGGAAAAATATCTATAAATGATTACATTTTTAAG
CTAAATAAAATGCAGATATTTTGGCTTCTTGTGAATGTAATAAAGAATCATAAAACATA

>4032_4032_4_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000371108_SLC22A15_chr1_116569514_ENST00000369503_length(amino acids)=375AA_BP=21
MEKWYLMTVVVLIGLTVRWTVSLNSYSGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAE
EALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYP
LCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFS
RVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEEALSLQALDPQQCVDKESSLGSESEE
EEEFYDADEETQMIK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ALG6-SLC22A15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALG6-SLC22A15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ALG6-SLC22A15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALG6C2930997Congenital disorder of glycosylation type 1C8CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0009402Colorectal Carcinoma1CTD_human
TgeneC0009404Colorectal Neoplasms1CTD_human