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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANAPC4-RBPJ (FusionGDB2 ID:HG29945TG3516)

Fusion Gene Summary for ANAPC4-RBPJ

check button Fusion gene summary
Fusion gene informationFusion gene name: ANAPC4-RBPJ
Fusion gene ID: hg29945tg3516
HgeneTgene
Gene symbol

ANAPC4

RBPJ

Gene ID

29945

3516

Gene nameanaphase promoting complex subunit 4recombination signal binding protein for immunoglobulin kappa J region
SynonymsAPC4AOS3|CBF1|IGKJRB|IGKJRB1|KBF2|RBP-J|RBPJK|RBPSUH|SUH|csl
Cytomap('ANAPC4')('RBPJ')

4p15.2

4p15.2

Type of geneprotein-codingprotein-coding
Descriptionanaphase-promoting complex subunit 4cyclosome subunit 4recombining binding protein suppressor of hairlessCBF-1H-2K binding factor-2RBP-J kappaRBP-JKimmunoglobulin kappa J region recombination signal binding protein 1renal carcinoma antigen NY-REN-30suppressor of hairless homolog
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000315368, ENST00000510092, 
Fusion gene scores* DoF score4 X 4 X 2=3213 X 11 X 7=1001
# samples 413
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(13/1001*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANAPC4 [Title/Abstract] AND RBPJ [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANAPC4(25398521)-RBPJ(26407797), # samples:1
Anticipated loss of major functional domain due to fusion event.ANAPC4-RBPJ seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANAPC4-RBPJ seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANAPC4

GO:0070979

protein K11-linked ubiquitination

18485873

TgeneRBPJ

GO:0007221

positive regulation of transcription of Notch receptor target

21102556

TgeneRBPJ

GO:0045892

negative regulation of transcription, DNA-templated

10713164

TgeneRBPJ

GO:0061419

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

23303788


check buttonFusion gene breakpoints across ANAPC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RBPJ (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-XK-AAJA-01AANAPC4chr4

25398521

+RBPJchr4

26407797

+


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Fusion Gene ORF analysis for ANAPC4-RBPJ

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000315368ENST00000511401ANAPC4chr4

25398521

+RBPJchr4

26407797

+
5CDS-3UTRENST00000510092ENST00000511401ANAPC4chr4

25398521

+RBPJchr4

26407797

+
5CDS-5UTRENST00000315368ENST00000342320ANAPC4chr4

25398521

+RBPJchr4

26407797

+
5CDS-5UTRENST00000315368ENST00000504907ANAPC4chr4

25398521

+RBPJchr4

26407797

+
5CDS-5UTRENST00000315368ENST00000507561ANAPC4chr4

25398521

+RBPJchr4

26407797

+
5CDS-5UTRENST00000510092ENST00000342320ANAPC4chr4

25398521

+RBPJchr4

26407797

+
5CDS-5UTRENST00000510092ENST00000504907ANAPC4chr4

25398521

+RBPJchr4

26407797

+
5CDS-5UTRENST00000510092ENST00000507561ANAPC4chr4

25398521

+RBPJchr4

26407797

+
In-frameENST00000315368ENST00000342295ANAPC4chr4

25398521

+RBPJchr4

26407797

+
In-frameENST00000315368ENST00000345843ANAPC4chr4

25398521

+RBPJchr4

26407797

+
In-frameENST00000315368ENST00000348160ANAPC4chr4

25398521

+RBPJchr4

26407797

+
In-frameENST00000315368ENST00000355476ANAPC4chr4

25398521

+RBPJchr4

26407797

+
In-frameENST00000315368ENST00000361572ANAPC4chr4

25398521

+RBPJchr4

26407797

+
In-frameENST00000510092ENST00000342295ANAPC4chr4

25398521

+RBPJchr4

26407797

+
In-frameENST00000510092ENST00000345843ANAPC4chr4

25398521

+RBPJchr4

26407797

+
In-frameENST00000510092ENST00000348160ANAPC4chr4

25398521

+RBPJchr4

26407797

+
In-frameENST00000510092ENST00000355476ANAPC4chr4

25398521

+RBPJchr4

26407797

+
In-frameENST00000510092ENST00000361572ANAPC4chr4

25398521

+RBPJchr4

26407797

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000315368ANAPC4chr425398521+ENST00000345843RBPJchr426407797+282013561422760872
ENST00000315368ANAPC4chr425398521+ENST00000342295RBPJchr426407797+341013561422760872
ENST00000315368ANAPC4chr425398521+ENST00000361572RBPJchr426407797+276113561422760873
ENST00000315368ANAPC4chr425398521+ENST00000348160RBPJchr426407797+282013561422760872
ENST00000315368ANAPC4chr425398521+ENST00000355476RBPJchr426407797+341013561422760872
ENST00000510092ANAPC4chr425398521+ENST00000345843RBPJchr426407797+27401276622680872
ENST00000510092ANAPC4chr425398521+ENST00000342295RBPJchr426407797+33301276622680872
ENST00000510092ANAPC4chr425398521+ENST00000361572RBPJchr426407797+26811276622680873
ENST00000510092ANAPC4chr425398521+ENST00000348160RBPJchr426407797+27401276622680872
ENST00000510092ANAPC4chr425398521+ENST00000355476RBPJchr426407797+33301276622680872

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000315368ENST00000345843ANAPC4chr425398521+RBPJchr426407797+0.0006237630.99937624
ENST00000315368ENST00000342295ANAPC4chr425398521+RBPJchr426407797+0.0003720610.99962795
ENST00000315368ENST00000361572ANAPC4chr425398521+RBPJchr426407797+0.0006943660.9993056
ENST00000315368ENST00000348160ANAPC4chr425398521+RBPJchr426407797+0.0006237630.99937624
ENST00000315368ENST00000355476ANAPC4chr425398521+RBPJchr426407797+0.0003720610.99962795
ENST00000510092ENST00000345843ANAPC4chr425398521+RBPJchr426407797+0.0006614030.99933857
ENST00000510092ENST00000342295ANAPC4chr425398521+RBPJchr426407797+0.0003718440.9996282
ENST00000510092ENST00000361572ANAPC4chr425398521+RBPJchr426407797+0.0007470390.999253
ENST00000510092ENST00000348160ANAPC4chr425398521+RBPJchr426407797+0.0006614030.99933857
ENST00000510092ENST00000355476ANAPC4chr425398521+RBPJchr426407797+0.0003718440.9996282

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Fusion Genomic Features for ANAPC4-RBPJ


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANAPC4chr425398521+RBPJchr426407796+8.62E-070.99999917
ANAPC4chr425398521+RBPJchr426407796+8.62E-070.99999917

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANAPC4-RBPJ


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:25398521/chr4:26407797)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRBPJchr4:25398521chr4:26407797ENST00000342295212355_44532501.0DomainNote=IPT/TIG
TgeneRBPJchr4:25398521chr4:26407797ENST00000342320111355_44518487.0DomainNote=IPT/TIG
TgeneRBPJchr4:25398521chr4:26407797ENST00000345843111355_44517486.0DomainNote=IPT/TIG
TgeneRBPJchr4:25398521chr4:26407797ENST00000348160111355_44519488.0DomainNote=IPT/TIG
TgeneRBPJchr4:25398521chr4:26407797ENST00000355476212355_44518487.0DomainNote=IPT/TIG
TgeneRBPJchr4:25398521chr4:26407797ENST00000361572111355_44532501.0DomainNote=IPT/TIG
TgeneRBPJchr4:25398521chr4:26407797ENST00000507561111355_4450466.0DomainNote=IPT/TIG
TgeneRBPJchr4:25398521chr4:26407797ENST00000342295212165_17032501.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST00000342295212192_19732501.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST0000034229521257_6732501.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST00000342320111165_17018487.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST00000342320111192_19718487.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST0000034232011157_6718487.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST00000345843111165_17017486.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST00000345843111192_19717486.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST0000034584311157_6717486.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST00000348160111165_17019488.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST00000348160111192_19719488.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST0000034816011157_6719488.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST00000355476212165_17018487.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST00000355476212192_19718487.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST0000035547621257_6718487.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST00000361572111165_17032501.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST00000361572111192_19732501.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST0000036157211157_6732501.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST00000507561111165_1700466.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST00000507561111192_1970466.0RegionDNA binding
TgeneRBPJchr4:25398521chr4:26407797ENST0000050756111157_670466.0RegionDNA binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANAPC4-RBPJ


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4292_4292_1_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000315368_RBPJ_chr4_26407797_ENST00000342295_length(transcript)=3410nt_BP=1356nt
CCCGACGCCGGAAGTGCCTGGAGCGCGCGACAGCGGCGGGGCGGGGCGGCCTGGAGGCTGTGGCGCGCGGCCGGCAGAGGGAGGGGAGAG
GCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCATCCTTCCGGGT
GGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACACAGCTGGCGA
GGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGTGTCTGGCATG
GAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGAGCTTACACTC
TTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATAATGCTGAGGA
TGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAAATTCTGATGA
AATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTTATGGAATGTT
TAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGGTCACAGAAGT
CTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTCGGATGGCCAG
AAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATACTAATGCAGAT
GGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTATGGGGGAAAGC
AAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCATCATACTCCAG
TATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGGCTTCATGGAA
GCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGGCAAATGAACT
TCTTCAGGAAGCTATGCGAAATTATTTAAAAGAGCGAGGGGATCAAACAGTACTTATTCTTCATGCAAAAGTTGCACAGAAGTCATATGG
AAATGAAAAAAGGTTTTTTTGCCCACCTCCTTGTGTATATCTTATGGGCAGTGGATGGAAGAAAAAAAAAGAACAAATGGAACGCGATGG
TTGTTCTGAACAAGAGTCTCAACCGTGTGCATTTATTGGGATAGGAAATAGTGACCAAGAAATGCAGCAGCTAAACTTGGAAGGAAAGAA
CTATTGCACAGCCAAAACATTGTATATATCTGACTCAGACAAGCGAAAGCACTTCATGTTGTCTGTAAAGATGTTCTATGGCAACAGTGA
TGACATTGGTGTGTTCCTCAGCAAGCGGATAAAAGTCATCTCCAAACCTTCCAAAAAGAAGCAGTCATTGAAAAATGCTGACTTATGCAT
TGCCTCAGGAACAAAGGTGGCTCTGTTTAATCGACTACGATCCCAGACAGTTAGTACCAGATACTTGCATGTAGAAGGAGGTAATTTTCA
TGCCAGTTCACAGCAGTGGGGAGCCTTTTTTATTCATCTCTTGGATGATGATGAATCAGAAGGAGAAGAATTCACAGTCCGAGATGGCTA
CATCCATTATGGACAAACAGTCAAACTTGTGTGCTCAGTTACTGGCATGGCACTCCCAAGATTGATAATTAGGAAAGTTGATAAGCAGAC
CGCATTATTGGATGCAGATGATCCTGTGTCACAACTCCATAAATGTGCATTTTACCTTAAGGATACAGAAAGAATGTATTTGTGCCTTTC
TCAAGAAAGAATAATTCAATTTCAGGCCACTCCATGTCCAAAAGAACCAAATAAAGAGATGATAAATGATGGCGCTTCCTGGACAATCAT
TAGCACAGATAAGGCAGAGTATACATTTTATGAGGGAATGGGCCCTGTCCTTGCCCCAGTCACTCCTGTGCCTGTGGTAGAGAGCCTTCA
GTTGAATGGCGGTGGGGACGTAGCAATGCTTGAACTTACAGGACAGAATTTCACTCCAAATTTACGAGTGTGGTTTGGGGATGTAGAAGC
TGAAACTATGTACAGGTGTGGAGAGAGTATGCTCTGTGTCGTCCCAGACATTTCTGCATTCCGAGAAGGTTGGAGATGGGTCCGGCAACC
AGTCCAGGTTCCAGTAACTTTGGTCCGAAATGATGGAATCATTTATTCCACCAGCCTTACCTTTACCTACACACCAGAACCAGGGCCGCG
GCCACATTGCAGTGCAGCAGGAGCAATCCTTCGAGCCAATTCAAGCCAGGTGCCCCCTAACGAATCAAACACAAACAGCGAGGGAAGTTA
CACAAACGCCAGCACAAATTCAACCAGTGTCACATCATCTACAGCCACAGTGGTATCCTAACTACCGTCTTTTTGCTAGGACTTAAACTG
ACTTGAGTGTGGCAAAAAGTTAACAAAAAAGGAGAAAAAATGAACAATCGTTTGTGGTTTCTTGGGAAAACTTTTCATACCAGGTGATAC
TATTCAAAAACCCCGTTGTCTCCCTGCAAGTGCTGATTTGAAATGCAGAAGCCACAGTAAAAAAAAAAAAAAAAAAAAAAAAAAAGAAAA
AAAAATCAAAATGTATAAATATTGGAAATCAAGTTTTTCAGCTGTTTTGTTGGTTGGTTGGTTGGTTTTTGTTTGGTTTTGTTTAAATGG
GCAAGAAGTAAATAATGTGGCTGGAATACAAGTTGAACAAACTAGAAGACACAAATCTAACATAGTTTTTATGGACCAAGGAACTTGTAT
ATTGTATAAGCTTTAGTAAAAGGTACATTTTCACCATACCTTTTTTTATATCACGGTATTATAGTACACCTTGTTACCAAATAGGTTGTT
CTCTTCCCCACCCACCTTTGAGCTTTTGCTCTAAAATACATTCAGGTTCCAAGCCTGACCATCCTTGTTTAATCTATCATACTCTTCCAG

>4292_4292_1_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000315368_RBPJ_chr4_26407797_ENST00000342295_length(amino acids)=872AA_BP=0
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQEAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGS
GWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPS
KKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMA
LPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVL
APVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYST

--------------------------------------------------------------
>4292_4292_2_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000315368_RBPJ_chr4_26407797_ENST00000345843_length(transcript)=2820nt_BP=1356nt
CCCGACGCCGGAAGTGCCTGGAGCGCGCGACAGCGGCGGGGCGGGGCGGCCTGGAGGCTGTGGCGCGCGGCCGGCAGAGGGAGGGGAGAG
GCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCATCCTTCCGGGT
GGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACACAGCTGGCGA
GGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGTGTCTGGCATG
GAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGAGCTTACACTC
TTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATAATGCTGAGGA
TGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAAATTCTGATGA
AATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTTATGGAATGTT
TAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGGTCACAGAAGT
CTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTCGGATGGCCAG
AAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATACTAATGCAGAT
GGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTATGGGGGAAAGC
AAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCATCATACTCCAG
TATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGGCTTCATGGAA
GCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGGCAAATGAACT
TCTTCAGGAAGCTATGCGAAATTATTTAAAAGAGCGAGGGGATCAAACAGTACTTATTCTTCATGCAAAAGTTGCACAGAAGTCATATGG
AAATGAAAAAAGGTTTTTTTGCCCACCTCCTTGTGTATATCTTATGGGCAGTGGATGGAAGAAAAAAAAAGAACAAATGGAACGCGATGG
TTGTTCTGAACAAGAGTCTCAACCGTGTGCATTTATTGGGATAGGAAATAGTGACCAAGAAATGCAGCAGCTAAACTTGGAAGGAAAGAA
CTATTGCACAGCCAAAACATTGTATATATCTGACTCAGACAAGCGAAAGCACTTCATGTTGTCTGTAAAGATGTTCTATGGCAACAGTGA
TGACATTGGTGTGTTCCTCAGCAAGCGGATAAAAGTCATCTCCAAACCTTCCAAAAAGAAGCAGTCATTGAAAAATGCTGACTTATGCAT
TGCCTCAGGAACAAAGGTGGCTCTGTTTAATCGACTACGATCCCAGACAGTTAGTACCAGATACTTGCATGTAGAAGGAGGTAATTTTCA
TGCCAGTTCACAGCAGTGGGGAGCCTTTTTTATTCATCTCTTGGATGATGATGAATCAGAAGGAGAAGAATTCACAGTCCGAGATGGCTA
CATCCATTATGGACAAACAGTCAAACTTGTGTGCTCAGTTACTGGCATGGCACTCCCAAGATTGATAATTAGGAAAGTTGATAAGCAGAC
CGCATTATTGGATGCAGATGATCCTGTGTCACAACTCCATAAATGTGCATTTTACCTTAAGGATACAGAAAGAATGTATTTGTGCCTTTC
TCAAGAAAGAATAATTCAATTTCAGGCCACTCCATGTCCAAAAGAACCAAATAAAGAGATGATAAATGATGGCGCTTCCTGGACAATCAT
TAGCACAGATAAGGCAGAGTATACATTTTATGAGGGAATGGGCCCTGTCCTTGCCCCAGTCACTCCTGTGCCTGTGGTAGAGAGCCTTCA
GTTGAATGGCGGTGGGGACGTAGCAATGCTTGAACTTACAGGACAGAATTTCACTCCAAATTTACGAGTGTGGTTTGGGGATGTAGAAGC
TGAAACTATGTACAGGTGTGGAGAGAGTATGCTCTGTGTCGTCCCAGACATTTCTGCATTCCGAGAAGGTTGGAGATGGGTCCGGCAACC
AGTCCAGGTTCCAGTAACTTTGGTCCGAAATGATGGAATCATTTATTCCACCAGCCTTACCTTTACCTACACACCAGAACCAGGGCCGCG
GCCACATTGCAGTGCAGCAGGAGCAATCCTTCGAGCCAATTCAAGCCAGGTGCCCCCTAACGAATCAAACACAAACAGCGAGGGAAGTTA
CACAAACGCCAGCACAAATTCAACCAGTGTCACATCATCTACAGCCACAGTGGTATCCTAACTACCGTCTTTTTGCTAGGACTTAAACTG

>4292_4292_2_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000315368_RBPJ_chr4_26407797_ENST00000345843_length(amino acids)=872AA_BP=0
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQEAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGS
GWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPS
KKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMA
LPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVL
APVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYST

--------------------------------------------------------------
>4292_4292_3_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000315368_RBPJ_chr4_26407797_ENST00000348160_length(transcript)=2820nt_BP=1356nt
CCCGACGCCGGAAGTGCCTGGAGCGCGCGACAGCGGCGGGGCGGGGCGGCCTGGAGGCTGTGGCGCGCGGCCGGCAGAGGGAGGGGAGAG
GCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCATCCTTCCGGGT
GGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACACAGCTGGCGA
GGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGTGTCTGGCATG
GAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGAGCTTACACTC
TTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATAATGCTGAGGA
TGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAAATTCTGATGA
AATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTTATGGAATGTT
TAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGGTCACAGAAGT
CTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTCGGATGGCCAG
AAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATACTAATGCAGAT
GGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTATGGGGGAAAGC
AAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCATCATACTCCAG
TATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGGCTTCATGGAA
GCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGGCAAATGAACT
TCTTCAGGAAGCTATGCGAAATTATTTAAAAGAGCGAGGGGATCAAACAGTACTTATTCTTCATGCAAAAGTTGCACAGAAGTCATATGG
AAATGAAAAAAGGTTTTTTTGCCCACCTCCTTGTGTATATCTTATGGGCAGTGGATGGAAGAAAAAAAAAGAACAAATGGAACGCGATGG
TTGTTCTGAACAAGAGTCTCAACCGTGTGCATTTATTGGGATAGGAAATAGTGACCAAGAAATGCAGCAGCTAAACTTGGAAGGAAAGAA
CTATTGCACAGCCAAAACATTGTATATATCTGACTCAGACAAGCGAAAGCACTTCATGTTGTCTGTAAAGATGTTCTATGGCAACAGTGA
TGACATTGGTGTGTTCCTCAGCAAGCGGATAAAAGTCATCTCCAAACCTTCCAAAAAGAAGCAGTCATTGAAAAATGCTGACTTATGCAT
TGCCTCAGGAACAAAGGTGGCTCTGTTTAATCGACTACGATCCCAGACAGTTAGTACCAGATACTTGCATGTAGAAGGAGGTAATTTTCA
TGCCAGTTCACAGCAGTGGGGAGCCTTTTTTATTCATCTCTTGGATGATGATGAATCAGAAGGAGAAGAATTCACAGTCCGAGATGGCTA
CATCCATTATGGACAAACAGTCAAACTTGTGTGCTCAGTTACTGGCATGGCACTCCCAAGATTGATAATTAGGAAAGTTGATAAGCAGAC
CGCATTATTGGATGCAGATGATCCTGTGTCACAACTCCATAAATGTGCATTTTACCTTAAGGATACAGAAAGAATGTATTTGTGCCTTTC
TCAAGAAAGAATAATTCAATTTCAGGCCACTCCATGTCCAAAAGAACCAAATAAAGAGATGATAAATGATGGCGCTTCCTGGACAATCAT
TAGCACAGATAAGGCAGAGTATACATTTTATGAGGGAATGGGCCCTGTCCTTGCCCCAGTCACTCCTGTGCCTGTGGTAGAGAGCCTTCA
GTTGAATGGCGGTGGGGACGTAGCAATGCTTGAACTTACAGGACAGAATTTCACTCCAAATTTACGAGTGTGGTTTGGGGATGTAGAAGC
TGAAACTATGTACAGGTGTGGAGAGAGTATGCTCTGTGTCGTCCCAGACATTTCTGCATTCCGAGAAGGTTGGAGATGGGTCCGGCAACC
AGTCCAGGTTCCAGTAACTTTGGTCCGAAATGATGGAATCATTTATTCCACCAGCCTTACCTTTACCTACACACCAGAACCAGGGCCGCG
GCCACATTGCAGTGCAGCAGGAGCAATCCTTCGAGCCAATTCAAGCCAGGTGCCCCCTAACGAATCAAACACAAACAGCGAGGGAAGTTA
CACAAACGCCAGCACAAATTCAACCAGTGTCACATCATCTACAGCCACAGTGGTATCCTAACTACCGTCTTTTTGCTAGGACTTAAACTG

>4292_4292_3_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000315368_RBPJ_chr4_26407797_ENST00000348160_length(amino acids)=872AA_BP=0
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQEAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGS
GWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPS
KKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMA
LPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVL
APVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYST

--------------------------------------------------------------
>4292_4292_4_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000315368_RBPJ_chr4_26407797_ENST00000355476_length(transcript)=3410nt_BP=1356nt
CCCGACGCCGGAAGTGCCTGGAGCGCGCGACAGCGGCGGGGCGGGGCGGCCTGGAGGCTGTGGCGCGCGGCCGGCAGAGGGAGGGGAGAG
GCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCATCCTTCCGGGT
GGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACACAGCTGGCGA
GGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGTGTCTGGCATG
GAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGAGCTTACACTC
TTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATAATGCTGAGGA
TGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAAATTCTGATGA
AATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTTATGGAATGTT
TAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGGTCACAGAAGT
CTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTCGGATGGCCAG
AAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATACTAATGCAGAT
GGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTATGGGGGAAAGC
AAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCATCATACTCCAG
TATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGGCTTCATGGAA
GCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGGCAAATGAACT
TCTTCAGGAAGCTATGCGAAATTATTTAAAAGAGCGAGGGGATCAAACAGTACTTATTCTTCATGCAAAAGTTGCACAGAAGTCATATGG
AAATGAAAAAAGGTTTTTTTGCCCACCTCCTTGTGTATATCTTATGGGCAGTGGATGGAAGAAAAAAAAAGAACAAATGGAACGCGATGG
TTGTTCTGAACAAGAGTCTCAACCGTGTGCATTTATTGGGATAGGAAATAGTGACCAAGAAATGCAGCAGCTAAACTTGGAAGGAAAGAA
CTATTGCACAGCCAAAACATTGTATATATCTGACTCAGACAAGCGAAAGCACTTCATGTTGTCTGTAAAGATGTTCTATGGCAACAGTGA
TGACATTGGTGTGTTCCTCAGCAAGCGGATAAAAGTCATCTCCAAACCTTCCAAAAAGAAGCAGTCATTGAAAAATGCTGACTTATGCAT
TGCCTCAGGAACAAAGGTGGCTCTGTTTAATCGACTACGATCCCAGACAGTTAGTACCAGATACTTGCATGTAGAAGGAGGTAATTTTCA
TGCCAGTTCACAGCAGTGGGGAGCCTTTTTTATTCATCTCTTGGATGATGATGAATCAGAAGGAGAAGAATTCACAGTCCGAGATGGCTA
CATCCATTATGGACAAACAGTCAAACTTGTGTGCTCAGTTACTGGCATGGCACTCCCAAGATTGATAATTAGGAAAGTTGATAAGCAGAC
CGCATTATTGGATGCAGATGATCCTGTGTCACAACTCCATAAATGTGCATTTTACCTTAAGGATACAGAAAGAATGTATTTGTGCCTTTC
TCAAGAAAGAATAATTCAATTTCAGGCCACTCCATGTCCAAAAGAACCAAATAAAGAGATGATAAATGATGGCGCTTCCTGGACAATCAT
TAGCACAGATAAGGCAGAGTATACATTTTATGAGGGAATGGGCCCTGTCCTTGCCCCAGTCACTCCTGTGCCTGTGGTAGAGAGCCTTCA
GTTGAATGGCGGTGGGGACGTAGCAATGCTTGAACTTACAGGACAGAATTTCACTCCAAATTTACGAGTGTGGTTTGGGGATGTAGAAGC
TGAAACTATGTACAGGTGTGGAGAGAGTATGCTCTGTGTCGTCCCAGACATTTCTGCATTCCGAGAAGGTTGGAGATGGGTCCGGCAACC
AGTCCAGGTTCCAGTAACTTTGGTCCGAAATGATGGAATCATTTATTCCACCAGCCTTACCTTTACCTACACACCAGAACCAGGGCCGCG
GCCACATTGCAGTGCAGCAGGAGCAATCCTTCGAGCCAATTCAAGCCAGGTGCCCCCTAACGAATCAAACACAAACAGCGAGGGAAGTTA
CACAAACGCCAGCACAAATTCAACCAGTGTCACATCATCTACAGCCACAGTGGTATCCTAACTACCGTCTTTTTGCTAGGACTTAAACTG
ACTTGAGTGTGGCAAAAAGTTAACAAAAAAGGAGAAAAAATGAACAATCGTTTGTGGTTTCTTGGGAAAACTTTTCATACCAGGTGATAC
TATTCAAAAACCCCGTTGTCTCCCTGCAAGTGCTGATTTGAAATGCAGAAGCCACAGTAAAAAAAAAAAAAAAAAAAAAAAAAAAGAAAA
AAAAATCAAAATGTATAAATATTGGAAATCAAGTTTTTCAGCTGTTTTGTTGGTTGGTTGGTTGGTTTTTGTTTGGTTTTGTTTAAATGG
GCAAGAAGTAAATAATGTGGCTGGAATACAAGTTGAACAAACTAGAAGACACAAATCTAACATAGTTTTTATGGACCAAGGAACTTGTAT
ATTGTATAAGCTTTAGTAAAAGGTACATTTTCACCATACCTTTTTTTATATCACGGTATTATAGTACACCTTGTTACCAAATAGGTTGTT
CTCTTCCCCACCCACCTTTGAGCTTTTGCTCTAAAATACATTCAGGTTCCAAGCCTGACCATCCTTGTTTAATCTATCATACTCTTCCAG

>4292_4292_4_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000315368_RBPJ_chr4_26407797_ENST00000355476_length(amino acids)=872AA_BP=0
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQEAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGS
GWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPS
KKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMA
LPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVL
APVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYST

--------------------------------------------------------------
>4292_4292_5_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000315368_RBPJ_chr4_26407797_ENST00000361572_length(transcript)=2761nt_BP=1356nt
CCCGACGCCGGAAGTGCCTGGAGCGCGCGACAGCGGCGGGGCGGGGCGGCCTGGAGGCTGTGGCGCGCGGCCGGCAGAGGGAGGGGAGAG
GCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCATCCTTCCGGGT
GGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACACAGCTGGCGA
GGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGTGTCTGGCATG
GAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGAGCTTACACTC
TTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATAATGCTGAGGA
TGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAAATTCTGATGA
AATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTTATGGAATGTT
TAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGGTCACAGAAGT
CTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTCGGATGGCCAG
AAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATACTAATGCAGAT
GGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTATGGGGGAAAGC
AAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCATCATACTCCAG
TATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGGCTTCATGGAA
GCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGGCAAATGAACT
TCTTCAGGAAGCTATGCGAAATTATTTAAAAGAGCGAGGGGATCAAACAGTACTTATTCTTCATGCAAAAGTTGCACAGAAGTCATATGG
AAATGAAAAAAGGTTTTTTTGCCCACCTCCTTGTGTATATCTTATGGGCAGTGGATGGAAGAAAAAAAAAGAACAAATGGAACGCGATGG
TTGTTCTGAACAAGAGTCTCAACCGTGTGCATTTATTGGGATAGGAAATAGTGACCAAGAAATGCAGCAGCTAAACTTGGAAGGAAAGAA
CTATTGCACAGCCAAAACATTGTATATATCTGACTCAGACAAGCGAAAGCACTTCATGTTGTCTGTAAAGATGTTCTATGGCAACAGTGA
TGACATTGGTGTGTTCCTCAGCAAGCGGATAAAAGTCATCTCCAAACCTTCCAAAAAGAAGCAGTCATTGAAAAATGCTGACTTATGCAT
TGCCTCAGGAACAAAGGTGGCTCTGTTTAATCGACTACGATCCCAGACAGTTAGTACCAGATACTTGCATGTAGAAGGAGGTAATTTTCA
TGCCAGTTCACAGCAGTGGGGAGCCTTTTTTATTCATCTCTTGGATGATGATGAATCAGAAGGAGAAGAATTCACAGTCCGAGATGGCTA
CATCCATTATGGACAAACAGTCAAACTTGTGTGCTCAGTTACTGGCATGGCACTCCCAAGATTGATAATTAGGAAAGTTGATAAGCAGAC
CGCATTATTGGATGCAGATGATCCTGTGTCACAACTCCATAAATGTGCATTTTACCTTAAGGATACAGAAAGAATGTATTTGTGCCTTTC
TCAAGAAAGAATAATTCAATTTCAGGCCACTCCATGTCCAAAAGAACCAAATAAAGAGATGATAAATGATGGCGCTTCCTGGACAATCAT
TAGCACAGATAAGGCAGAGTATACATTTTATGAGGGAATGGGCCCTGTCCTTGCCCCAGTCACTCCTGTGCCTGTGGTAGAGAGCCTTCA
GTTGAATGGCGGTGGGGACGTAGCAATGCTTGAACTTACAGGACAGAATTTCACTCCAAATTTACGAGTGTGGTTTGGGGATGTAGAAGC
TGAAACTATGTACAGGTGTGGAGAGAGTATGCTCTGTGTCGTCCCAGACATTTCTGCATTCCGAGAAGGTTGGAGATGGGTCCGGCAACC
AGTCCAGGTTCCAGTAACTTTGGTCCGAAATGATGGAATCATTTATTCCACCAGCCTTACCTTTACCTACACACCAGAACCAGGGCCGCG
GCCACATTGCAGTGCAGCAGGAGCAATCCTTCGAGCCAATTCAAGCCAGGTGCCCCCTAACGAATCAAACACAAACAGCGAGGGAAGTTA

>4292_4292_5_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000315368_RBPJ_chr4_26407797_ENST00000361572_length(amino acids)=873AA_BP=0
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQEAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGS
GWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPS
KKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMA
LPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVL
APVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYST

--------------------------------------------------------------
>4292_4292_6_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000510092_RBPJ_chr4_26407797_ENST00000342295_length(transcript)=3330nt_BP=1276nt
GAGGGGAGAGGCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCAT
CCTTCCGGGTGGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACA
CAGCTGGCGAGGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGT
GTCTGGCATGGAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGA
GCTTACACTCTTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATA
ATGCTGAGGATGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAA
ATTCTGATGAAATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTT
ATGGAATGTTTAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGG
TCACAGAAGTCTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTC
GGATGGCCAGAAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATAC
TAATGCAGATGGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTAT
GGGGGAAAGCAAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCAT
CATACTCCAGTATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGG
CTTCATGGAAGCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGG
CAAATGAACTTCTTCAGGAAGCTATGCGAAATTATTTAAAAGAGCGAGGGGATCAAACAGTACTTATTCTTCATGCAAAAGTTGCACAGA
AGTCATATGGAAATGAAAAAAGGTTTTTTTGCCCACCTCCTTGTGTATATCTTATGGGCAGTGGATGGAAGAAAAAAAAAGAACAAATGG
AACGCGATGGTTGTTCTGAACAAGAGTCTCAACCGTGTGCATTTATTGGGATAGGAAATAGTGACCAAGAAATGCAGCAGCTAAACTTGG
AAGGAAAGAACTATTGCACAGCCAAAACATTGTATATATCTGACTCAGACAAGCGAAAGCACTTCATGTTGTCTGTAAAGATGTTCTATG
GCAACAGTGATGACATTGGTGTGTTCCTCAGCAAGCGGATAAAAGTCATCTCCAAACCTTCCAAAAAGAAGCAGTCATTGAAAAATGCTG
ACTTATGCATTGCCTCAGGAACAAAGGTGGCTCTGTTTAATCGACTACGATCCCAGACAGTTAGTACCAGATACTTGCATGTAGAAGGAG
GTAATTTTCATGCCAGTTCACAGCAGTGGGGAGCCTTTTTTATTCATCTCTTGGATGATGATGAATCAGAAGGAGAAGAATTCACAGTCC
GAGATGGCTACATCCATTATGGACAAACAGTCAAACTTGTGTGCTCAGTTACTGGCATGGCACTCCCAAGATTGATAATTAGGAAAGTTG
ATAAGCAGACCGCATTATTGGATGCAGATGATCCTGTGTCACAACTCCATAAATGTGCATTTTACCTTAAGGATACAGAAAGAATGTATT
TGTGCCTTTCTCAAGAAAGAATAATTCAATTTCAGGCCACTCCATGTCCAAAAGAACCAAATAAAGAGATGATAAATGATGGCGCTTCCT
GGACAATCATTAGCACAGATAAGGCAGAGTATACATTTTATGAGGGAATGGGCCCTGTCCTTGCCCCAGTCACTCCTGTGCCTGTGGTAG
AGAGCCTTCAGTTGAATGGCGGTGGGGACGTAGCAATGCTTGAACTTACAGGACAGAATTTCACTCCAAATTTACGAGTGTGGTTTGGGG
ATGTAGAAGCTGAAACTATGTACAGGTGTGGAGAGAGTATGCTCTGTGTCGTCCCAGACATTTCTGCATTCCGAGAAGGTTGGAGATGGG
TCCGGCAACCAGTCCAGGTTCCAGTAACTTTGGTCCGAAATGATGGAATCATTTATTCCACCAGCCTTACCTTTACCTACACACCAGAAC
CAGGGCCGCGGCCACATTGCAGTGCAGCAGGAGCAATCCTTCGAGCCAATTCAAGCCAGGTGCCCCCTAACGAATCAAACACAAACAGCG
AGGGAAGTTACACAAACGCCAGCACAAATTCAACCAGTGTCACATCATCTACAGCCACAGTGGTATCCTAACTACCGTCTTTTTGCTAGG
ACTTAAACTGACTTGAGTGTGGCAAAAAGTTAACAAAAAAGGAGAAAAAATGAACAATCGTTTGTGGTTTCTTGGGAAAACTTTTCATAC
CAGGTGATACTATTCAAAAACCCCGTTGTCTCCCTGCAAGTGCTGATTTGAAATGCAGAAGCCACAGTAAAAAAAAAAAAAAAAAAAAAA
AAAAAGAAAAAAAAATCAAAATGTATAAATATTGGAAATCAAGTTTTTCAGCTGTTTTGTTGGTTGGTTGGTTGGTTTTTGTTTGGTTTT
GTTTAAATGGGCAAGAAGTAAATAATGTGGCTGGAATACAAGTTGAACAAACTAGAAGACACAAATCTAACATAGTTTTTATGGACCAAG
GAACTTGTATATTGTATAAGCTTTAGTAAAAGGTACATTTTCACCATACCTTTTTTTATATCACGGTATTATAGTACACCTTGTTACCAA
ATAGGTTGTTCTCTTCCCCACCCACCTTTGAGCTTTTGCTCTAAAATACATTCAGGTTCCAAGCCTGACCATCCTTGTTTAATCTATCAT
ACTCTTCCAGGTTTTTTTTTTTTGGTCTAAGGCTGGAACTTTTTTCTTTTTTTTCAGCTGAAGTCTTATGACTTTTCATGAGTCAAAATT

>4292_4292_6_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000510092_RBPJ_chr4_26407797_ENST00000342295_length(amino acids)=872AA_BP=0
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQEAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGS
GWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPS
KKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMA
LPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVL
APVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYST

--------------------------------------------------------------
>4292_4292_7_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000510092_RBPJ_chr4_26407797_ENST00000345843_length(transcript)=2740nt_BP=1276nt
GAGGGGAGAGGCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCAT
CCTTCCGGGTGGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACA
CAGCTGGCGAGGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGT
GTCTGGCATGGAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGA
GCTTACACTCTTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATA
ATGCTGAGGATGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAA
ATTCTGATGAAATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTT
ATGGAATGTTTAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGG
TCACAGAAGTCTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTC
GGATGGCCAGAAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATAC
TAATGCAGATGGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTAT
GGGGGAAAGCAAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCAT
CATACTCCAGTATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGG
CTTCATGGAAGCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGG
CAAATGAACTTCTTCAGGAAGCTATGCGAAATTATTTAAAAGAGCGAGGGGATCAAACAGTACTTATTCTTCATGCAAAAGTTGCACAGA
AGTCATATGGAAATGAAAAAAGGTTTTTTTGCCCACCTCCTTGTGTATATCTTATGGGCAGTGGATGGAAGAAAAAAAAAGAACAAATGG
AACGCGATGGTTGTTCTGAACAAGAGTCTCAACCGTGTGCATTTATTGGGATAGGAAATAGTGACCAAGAAATGCAGCAGCTAAACTTGG
AAGGAAAGAACTATTGCACAGCCAAAACATTGTATATATCTGACTCAGACAAGCGAAAGCACTTCATGTTGTCTGTAAAGATGTTCTATG
GCAACAGTGATGACATTGGTGTGTTCCTCAGCAAGCGGATAAAAGTCATCTCCAAACCTTCCAAAAAGAAGCAGTCATTGAAAAATGCTG
ACTTATGCATTGCCTCAGGAACAAAGGTGGCTCTGTTTAATCGACTACGATCCCAGACAGTTAGTACCAGATACTTGCATGTAGAAGGAG
GTAATTTTCATGCCAGTTCACAGCAGTGGGGAGCCTTTTTTATTCATCTCTTGGATGATGATGAATCAGAAGGAGAAGAATTCACAGTCC
GAGATGGCTACATCCATTATGGACAAACAGTCAAACTTGTGTGCTCAGTTACTGGCATGGCACTCCCAAGATTGATAATTAGGAAAGTTG
ATAAGCAGACCGCATTATTGGATGCAGATGATCCTGTGTCACAACTCCATAAATGTGCATTTTACCTTAAGGATACAGAAAGAATGTATT
TGTGCCTTTCTCAAGAAAGAATAATTCAATTTCAGGCCACTCCATGTCCAAAAGAACCAAATAAAGAGATGATAAATGATGGCGCTTCCT
GGACAATCATTAGCACAGATAAGGCAGAGTATACATTTTATGAGGGAATGGGCCCTGTCCTTGCCCCAGTCACTCCTGTGCCTGTGGTAG
AGAGCCTTCAGTTGAATGGCGGTGGGGACGTAGCAATGCTTGAACTTACAGGACAGAATTTCACTCCAAATTTACGAGTGTGGTTTGGGG
ATGTAGAAGCTGAAACTATGTACAGGTGTGGAGAGAGTATGCTCTGTGTCGTCCCAGACATTTCTGCATTCCGAGAAGGTTGGAGATGGG
TCCGGCAACCAGTCCAGGTTCCAGTAACTTTGGTCCGAAATGATGGAATCATTTATTCCACCAGCCTTACCTTTACCTACACACCAGAAC
CAGGGCCGCGGCCACATTGCAGTGCAGCAGGAGCAATCCTTCGAGCCAATTCAAGCCAGGTGCCCCCTAACGAATCAAACACAAACAGCG
AGGGAAGTTACACAAACGCCAGCACAAATTCAACCAGTGTCACATCATCTACAGCCACAGTGGTATCCTAACTACCGTCTTTTTGCTAGG

>4292_4292_7_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000510092_RBPJ_chr4_26407797_ENST00000345843_length(amino acids)=872AA_BP=0
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQEAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGS
GWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPS
KKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMA
LPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVL
APVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYST

--------------------------------------------------------------
>4292_4292_8_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000510092_RBPJ_chr4_26407797_ENST00000348160_length(transcript)=2740nt_BP=1276nt
GAGGGGAGAGGCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCAT
CCTTCCGGGTGGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACA
CAGCTGGCGAGGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGT
GTCTGGCATGGAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGA
GCTTACACTCTTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATA
ATGCTGAGGATGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAA
ATTCTGATGAAATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTT
ATGGAATGTTTAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGG
TCACAGAAGTCTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTC
GGATGGCCAGAAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATAC
TAATGCAGATGGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTAT
GGGGGAAAGCAAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCAT
CATACTCCAGTATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGG
CTTCATGGAAGCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGG
CAAATGAACTTCTTCAGGAAGCTATGCGAAATTATTTAAAAGAGCGAGGGGATCAAACAGTACTTATTCTTCATGCAAAAGTTGCACAGA
AGTCATATGGAAATGAAAAAAGGTTTTTTTGCCCACCTCCTTGTGTATATCTTATGGGCAGTGGATGGAAGAAAAAAAAAGAACAAATGG
AACGCGATGGTTGTTCTGAACAAGAGTCTCAACCGTGTGCATTTATTGGGATAGGAAATAGTGACCAAGAAATGCAGCAGCTAAACTTGG
AAGGAAAGAACTATTGCACAGCCAAAACATTGTATATATCTGACTCAGACAAGCGAAAGCACTTCATGTTGTCTGTAAAGATGTTCTATG
GCAACAGTGATGACATTGGTGTGTTCCTCAGCAAGCGGATAAAAGTCATCTCCAAACCTTCCAAAAAGAAGCAGTCATTGAAAAATGCTG
ACTTATGCATTGCCTCAGGAACAAAGGTGGCTCTGTTTAATCGACTACGATCCCAGACAGTTAGTACCAGATACTTGCATGTAGAAGGAG
GTAATTTTCATGCCAGTTCACAGCAGTGGGGAGCCTTTTTTATTCATCTCTTGGATGATGATGAATCAGAAGGAGAAGAATTCACAGTCC
GAGATGGCTACATCCATTATGGACAAACAGTCAAACTTGTGTGCTCAGTTACTGGCATGGCACTCCCAAGATTGATAATTAGGAAAGTTG
ATAAGCAGACCGCATTATTGGATGCAGATGATCCTGTGTCACAACTCCATAAATGTGCATTTTACCTTAAGGATACAGAAAGAATGTATT
TGTGCCTTTCTCAAGAAAGAATAATTCAATTTCAGGCCACTCCATGTCCAAAAGAACCAAATAAAGAGATGATAAATGATGGCGCTTCCT
GGACAATCATTAGCACAGATAAGGCAGAGTATACATTTTATGAGGGAATGGGCCCTGTCCTTGCCCCAGTCACTCCTGTGCCTGTGGTAG
AGAGCCTTCAGTTGAATGGCGGTGGGGACGTAGCAATGCTTGAACTTACAGGACAGAATTTCACTCCAAATTTACGAGTGTGGTTTGGGG
ATGTAGAAGCTGAAACTATGTACAGGTGTGGAGAGAGTATGCTCTGTGTCGTCCCAGACATTTCTGCATTCCGAGAAGGTTGGAGATGGG
TCCGGCAACCAGTCCAGGTTCCAGTAACTTTGGTCCGAAATGATGGAATCATTTATTCCACCAGCCTTACCTTTACCTACACACCAGAAC
CAGGGCCGCGGCCACATTGCAGTGCAGCAGGAGCAATCCTTCGAGCCAATTCAAGCCAGGTGCCCCCTAACGAATCAAACACAAACAGCG
AGGGAAGTTACACAAACGCCAGCACAAATTCAACCAGTGTCACATCATCTACAGCCACAGTGGTATCCTAACTACCGTCTTTTTGCTAGG

>4292_4292_8_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000510092_RBPJ_chr4_26407797_ENST00000348160_length(amino acids)=872AA_BP=0
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQEAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGS
GWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPS
KKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMA
LPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVL
APVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYST

--------------------------------------------------------------
>4292_4292_9_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000510092_RBPJ_chr4_26407797_ENST00000355476_length(transcript)=3330nt_BP=1276nt
GAGGGGAGAGGCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCAT
CCTTCCGGGTGGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACA
CAGCTGGCGAGGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGT
GTCTGGCATGGAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGA
GCTTACACTCTTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATA
ATGCTGAGGATGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAA
ATTCTGATGAAATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTT
ATGGAATGTTTAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGG
TCACAGAAGTCTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTC
GGATGGCCAGAAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATAC
TAATGCAGATGGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTAT
GGGGGAAAGCAAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCAT
CATACTCCAGTATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGG
CTTCATGGAAGCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGG
CAAATGAACTTCTTCAGGAAGCTATGCGAAATTATTTAAAAGAGCGAGGGGATCAAACAGTACTTATTCTTCATGCAAAAGTTGCACAGA
AGTCATATGGAAATGAAAAAAGGTTTTTTTGCCCACCTCCTTGTGTATATCTTATGGGCAGTGGATGGAAGAAAAAAAAAGAACAAATGG
AACGCGATGGTTGTTCTGAACAAGAGTCTCAACCGTGTGCATTTATTGGGATAGGAAATAGTGACCAAGAAATGCAGCAGCTAAACTTGG
AAGGAAAGAACTATTGCACAGCCAAAACATTGTATATATCTGACTCAGACAAGCGAAAGCACTTCATGTTGTCTGTAAAGATGTTCTATG
GCAACAGTGATGACATTGGTGTGTTCCTCAGCAAGCGGATAAAAGTCATCTCCAAACCTTCCAAAAAGAAGCAGTCATTGAAAAATGCTG
ACTTATGCATTGCCTCAGGAACAAAGGTGGCTCTGTTTAATCGACTACGATCCCAGACAGTTAGTACCAGATACTTGCATGTAGAAGGAG
GTAATTTTCATGCCAGTTCACAGCAGTGGGGAGCCTTTTTTATTCATCTCTTGGATGATGATGAATCAGAAGGAGAAGAATTCACAGTCC
GAGATGGCTACATCCATTATGGACAAACAGTCAAACTTGTGTGCTCAGTTACTGGCATGGCACTCCCAAGATTGATAATTAGGAAAGTTG
ATAAGCAGACCGCATTATTGGATGCAGATGATCCTGTGTCACAACTCCATAAATGTGCATTTTACCTTAAGGATACAGAAAGAATGTATT
TGTGCCTTTCTCAAGAAAGAATAATTCAATTTCAGGCCACTCCATGTCCAAAAGAACCAAATAAAGAGATGATAAATGATGGCGCTTCCT
GGACAATCATTAGCACAGATAAGGCAGAGTATACATTTTATGAGGGAATGGGCCCTGTCCTTGCCCCAGTCACTCCTGTGCCTGTGGTAG
AGAGCCTTCAGTTGAATGGCGGTGGGGACGTAGCAATGCTTGAACTTACAGGACAGAATTTCACTCCAAATTTACGAGTGTGGTTTGGGG
ATGTAGAAGCTGAAACTATGTACAGGTGTGGAGAGAGTATGCTCTGTGTCGTCCCAGACATTTCTGCATTCCGAGAAGGTTGGAGATGGG
TCCGGCAACCAGTCCAGGTTCCAGTAACTTTGGTCCGAAATGATGGAATCATTTATTCCACCAGCCTTACCTTTACCTACACACCAGAAC
CAGGGCCGCGGCCACATTGCAGTGCAGCAGGAGCAATCCTTCGAGCCAATTCAAGCCAGGTGCCCCCTAACGAATCAAACACAAACAGCG
AGGGAAGTTACACAAACGCCAGCACAAATTCAACCAGTGTCACATCATCTACAGCCACAGTGGTATCCTAACTACCGTCTTTTTGCTAGG
ACTTAAACTGACTTGAGTGTGGCAAAAAGTTAACAAAAAAGGAGAAAAAATGAACAATCGTTTGTGGTTTCTTGGGAAAACTTTTCATAC
CAGGTGATACTATTCAAAAACCCCGTTGTCTCCCTGCAAGTGCTGATTTGAAATGCAGAAGCCACAGTAAAAAAAAAAAAAAAAAAAAAA
AAAAAGAAAAAAAAATCAAAATGTATAAATATTGGAAATCAAGTTTTTCAGCTGTTTTGTTGGTTGGTTGGTTGGTTTTTGTTTGGTTTT
GTTTAAATGGGCAAGAAGTAAATAATGTGGCTGGAATACAAGTTGAACAAACTAGAAGACACAAATCTAACATAGTTTTTATGGACCAAG
GAACTTGTATATTGTATAAGCTTTAGTAAAAGGTACATTTTCACCATACCTTTTTTTATATCACGGTATTATAGTACACCTTGTTACCAA
ATAGGTTGTTCTCTTCCCCACCCACCTTTGAGCTTTTGCTCTAAAATACATTCAGGTTCCAAGCCTGACCATCCTTGTTTAATCTATCAT
ACTCTTCCAGGTTTTTTTTTTTTGGTCTAAGGCTGGAACTTTTTTCTTTTTTTTCAGCTGAAGTCTTATGACTTTTCATGAGTCAAAATT

>4292_4292_9_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000510092_RBPJ_chr4_26407797_ENST00000355476_length(amino acids)=872AA_BP=0
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQEAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGS
GWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPS
KKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMA
LPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVL
APVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYST

--------------------------------------------------------------
>4292_4292_10_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000510092_RBPJ_chr4_26407797_ENST00000361572_length(transcript)=2681nt_BP=1276nt
GAGGGGAGAGGCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCAT
CCTTCCGGGTGGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACA
CAGCTGGCGAGGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGT
GTCTGGCATGGAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGA
GCTTACACTCTTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATA
ATGCTGAGGATGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAA
ATTCTGATGAAATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTT
ATGGAATGTTTAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGG
TCACAGAAGTCTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTC
GGATGGCCAGAAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATAC
TAATGCAGATGGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTAT
GGGGGAAAGCAAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCAT
CATACTCCAGTATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGG
CTTCATGGAAGCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGG
CAAATGAACTTCTTCAGGAAGCTATGCGAAATTATTTAAAAGAGCGAGGGGATCAAACAGTACTTATTCTTCATGCAAAAGTTGCACAGA
AGTCATATGGAAATGAAAAAAGGTTTTTTTGCCCACCTCCTTGTGTATATCTTATGGGCAGTGGATGGAAGAAAAAAAAAGAACAAATGG
AACGCGATGGTTGTTCTGAACAAGAGTCTCAACCGTGTGCATTTATTGGGATAGGAAATAGTGACCAAGAAATGCAGCAGCTAAACTTGG
AAGGAAAGAACTATTGCACAGCCAAAACATTGTATATATCTGACTCAGACAAGCGAAAGCACTTCATGTTGTCTGTAAAGATGTTCTATG
GCAACAGTGATGACATTGGTGTGTTCCTCAGCAAGCGGATAAAAGTCATCTCCAAACCTTCCAAAAAGAAGCAGTCATTGAAAAATGCTG
ACTTATGCATTGCCTCAGGAACAAAGGTGGCTCTGTTTAATCGACTACGATCCCAGACAGTTAGTACCAGATACTTGCATGTAGAAGGAG
GTAATTTTCATGCCAGTTCACAGCAGTGGGGAGCCTTTTTTATTCATCTCTTGGATGATGATGAATCAGAAGGAGAAGAATTCACAGTCC
GAGATGGCTACATCCATTATGGACAAACAGTCAAACTTGTGTGCTCAGTTACTGGCATGGCACTCCCAAGATTGATAATTAGGAAAGTTG
ATAAGCAGACCGCATTATTGGATGCAGATGATCCTGTGTCACAACTCCATAAATGTGCATTTTACCTTAAGGATACAGAAAGAATGTATT
TGTGCCTTTCTCAAGAAAGAATAATTCAATTTCAGGCCACTCCATGTCCAAAAGAACCAAATAAAGAGATGATAAATGATGGCGCTTCCT
GGACAATCATTAGCACAGATAAGGCAGAGTATACATTTTATGAGGGAATGGGCCCTGTCCTTGCCCCAGTCACTCCTGTGCCTGTGGTAG
AGAGCCTTCAGTTGAATGGCGGTGGGGACGTAGCAATGCTTGAACTTACAGGACAGAATTTCACTCCAAATTTACGAGTGTGGTTTGGGG
ATGTAGAAGCTGAAACTATGTACAGGTGTGGAGAGAGTATGCTCTGTGTCGTCCCAGACATTTCTGCATTCCGAGAAGGTTGGAGATGGG
TCCGGCAACCAGTCCAGGTTCCAGTAACTTTGGTCCGAAATGATGGAATCATTTATTCCACCAGCCTTACCTTTACCTACACACCAGAAC
CAGGGCCGCGGCCACATTGCAGTGCAGCAGGAGCAATCCTTCGAGCCAATTCAAGCCAGGTGCCCCCTAACGAATCAAACACAAACAGCG

>4292_4292_10_ANAPC4-RBPJ_ANAPC4_chr4_25398521_ENST00000510092_RBPJ_chr4_26407797_ENST00000361572_length(amino acids)=873AA_BP=0
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQEAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGS
GWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPS
KKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMA
LPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVL
APVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYST

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Fusion Gene PPI Analysis for ANAPC4-RBPJ


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANAPC4-RBPJ


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANAPC4-RBPJ


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3553748ADAMS-OLIVER SYNDROME 33GENOMICS_ENGLAND;UNIPROT
TgeneC0003873Rheumatoid Arthritis2CTD_human
TgeneC4551482Adams-Oliver syndrome 12CTD_human;GENOMICS_ENGLAND
TgeneC0014175Endometriosis1CTD_human
TgeneC0026769Multiple Sclerosis1CTD_human
TgeneC0265268Adams Oliver syndrome1ORPHANET
TgeneC0269102Endometrioma1CTD_human
TgeneC0751324Multiple Sclerosis, Acute Fulminating1CTD_human