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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ABR-CRK (FusionGDB2 ID:HG29TG1398) |
Fusion Gene Summary for ABR-CRK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ABR-CRK | Fusion gene ID: hg29tg1398 | Hgene | Tgene | Gene symbol | ABR | CRK | Gene ID | 29 | 1398 |
| Gene name | ABR activator of RhoGEF and GTPase | CRK proto-oncogene, adaptor protein | |
| Synonyms | MDB | CRKII|p38 | |
| Cytomap | ('ABR')('CRK') 17p13.3 | 17p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | active breakpoint cluster region-related proteinABR, RhoGEF and GTPase activating proteinactive BCR-related | adapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like protein | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | Q12979 | P46108 | |
| Ensembl transtripts involved in fusion gene | ENST00000291107, ENST00000302538, ENST00000544583, ENST00000574437, ENST00000536794, ENST00000543210, ENST00000572441, ENST00000573895, | ENST00000544583, ENST00000574437, ENST00000291107, ENST00000536794, ENST00000543210, ENST00000572441, ENST00000573895, ENST00000302538, | |
| Fusion gene scores | * DoF score | 23 X 15 X 14=4830 | 9 X 8 X 3=216 |
| # samples | 36 | 9 | |
| ** MAII score | log2(36/4830*10)=-3.74595437739346 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ABR [Title/Abstract] AND CRK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ABR(994905)-CRK(1340449), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | ABR-CRK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABR-CRK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABR-CRK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ABR-CRK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CRK-ABR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CRK-ABR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ABR-CRK seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ABR | GO:0090630 | activation of GTPase activity | 7479768 |
| Tgene | CRK | GO:0009966 | regulation of signal transduction | 17515907 |
| Tgene | CRK | GO:0032956 | regulation of actin cytoskeleton organization | 11870224 |
| Tgene | CRK | GO:0043087 | regulation of GTPase activity | 11870224 |
| Tgene | CRK | GO:0048013 | ephrin receptor signaling pathway | 11870224 |
| Tgene | CRK | GO:0061045 | negative regulation of wound healing | 17515907 |
| Tgene | CRK | GO:2000146 | negative regulation of cell motility | 17515907 |
| Fusion gene breakpoints across ABR (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CRK (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUAD | TCGA-44-7662-01A | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
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Fusion Gene ORF analysis for ABR-CRK |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000291107 | ENST00000572145 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| 5CDS-5UTR | ENST00000302538 | ENST00000572145 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| 5CDS-5UTR | ENST00000544583 | ENST00000572145 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| 5CDS-5UTR | ENST00000574437 | ENST00000572145 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| Frame-shift | ENST00000291107 | ENST00000300574 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| Frame-shift | ENST00000291107 | ENST00000398970 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| Frame-shift | ENST00000291107 | ENST00000574295 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| Frame-shift | ENST00000302538 | ENST00000300574 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| Frame-shift | ENST00000302538 | ENST00000398970 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| Frame-shift | ENST00000302538 | ENST00000574295 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| Frame-shift | ENST00000574437 | ENST00000300574 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| Frame-shift | ENST00000574437 | ENST00000398970 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| Frame-shift | ENST00000574437 | ENST00000574295 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| In-frame | ENST00000544583 | ENST00000300574 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| In-frame | ENST00000544583 | ENST00000398970 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| In-frame | ENST00000544583 | ENST00000574295 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-3CDS | ENST00000536794 | ENST00000300574 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-3CDS | ENST00000536794 | ENST00000398970 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-3CDS | ENST00000536794 | ENST00000574295 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-3CDS | ENST00000543210 | ENST00000300574 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-3CDS | ENST00000543210 | ENST00000398970 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-3CDS | ENST00000543210 | ENST00000574295 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-3CDS | ENST00000572441 | ENST00000300574 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-3CDS | ENST00000572441 | ENST00000398970 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-3CDS | ENST00000572441 | ENST00000574295 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-3CDS | ENST00000573895 | ENST00000300574 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-3CDS | ENST00000573895 | ENST00000398970 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-3CDS | ENST00000573895 | ENST00000574295 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-5UTR | ENST00000536794 | ENST00000572145 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-5UTR | ENST00000543210 | ENST00000572145 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-5UTR | ENST00000572441 | ENST00000572145 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| intron-5UTR | ENST00000573895 | ENST00000572145 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000544583 | ABR | chr17 | 994905 | - | ENST00000398970 | CRK | chr17 | 1340449 | - | 4321 | 993 | 1040 | 591 | 149 |
| ENST00000544583 | ABR | chr17 | 994905 | - | ENST00000300574 | CRK | chr17 | 1340449 | - | 4491 | 993 | 1040 | 1666 | 208 |
| ENST00000544583 | ABR | chr17 | 994905 | - | ENST00000574295 | CRK | chr17 | 1340449 | - | 2111 | 993 | 529 | 38 | 163 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000544583 | ENST00000398970 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - | 0.0172083 | 0.9827917 |
| ENST00000544583 | ENST00000300574 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - | 0.018289877 | 0.98171014 |
| ENST00000544583 | ENST00000574295 | ABR | chr17 | 994905 | - | CRK | chr17 | 1340449 | - | 0.014658999 | 0.985341 |
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Fusion Genomic Features for ABR-CRK |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ABR-CRK |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:994905/chr17:1340449) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ABR | CRK |
| FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). {ECO:0000250|UniProtKB:Q5SSL4, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:7479768}. | FUNCTION: Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CRK | chr17:994905 | chr17:1340449 | ENST00000300574 | 0 | 3 | 132_192 | 80 | 305.0 | Domain | SH3 1 | |
| Tgene | CRK | chr17:994905 | chr17:1340449 | ENST00000300574 | 0 | 3 | 235_296 | 80 | 305.0 | Domain | SH3 2 | |
| Tgene | CRK | chr17:994905 | chr17:1340449 | ENST00000398970 | 0 | 3 | 132_192 | 80 | 205.0 | Domain | SH3 1 | |
| Tgene | CRK | chr17:994905 | chr17:1340449 | ENST00000398970 | 0 | 3 | 235_296 | 80 | 205.0 | Domain | SH3 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000291107 | - | 3 | 22 | 417_420 | 140 | 823.0 | Compositional bias | Note=Poly-Leu |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000302538 | - | 4 | 23 | 417_420 | 177 | 860.0 | Compositional bias | Note=Poly-Leu |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000543210 | - | 1 | 8 | 417_420 | 0 | 311.0 | Compositional bias | Note=Poly-Leu |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000544583 | - | 4 | 23 | 417_420 | 131 | 814.0 | Compositional bias | Note=Poly-Leu |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000574437 | - | 3 | 22 | 417_420 | 131 | 814.0 | Compositional bias | Note=Poly-Leu |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000291107 | - | 3 | 22 | 301_459 | 140 | 823.0 | Domain | PH |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000291107 | - | 3 | 22 | 484_613 | 140 | 823.0 | Domain | C2 |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000291107 | - | 3 | 22 | 647_845 | 140 | 823.0 | Domain | Rho-GAP |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000291107 | - | 3 | 22 | 91_284 | 140 | 823.0 | Domain | DH |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000302538 | - | 4 | 23 | 301_459 | 177 | 860.0 | Domain | PH |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000302538 | - | 4 | 23 | 484_613 | 177 | 860.0 | Domain | C2 |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000302538 | - | 4 | 23 | 647_845 | 177 | 860.0 | Domain | Rho-GAP |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000302538 | - | 4 | 23 | 91_284 | 177 | 860.0 | Domain | DH |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000543210 | - | 1 | 8 | 301_459 | 0 | 311.0 | Domain | PH |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000543210 | - | 1 | 8 | 484_613 | 0 | 311.0 | Domain | C2 |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000543210 | - | 1 | 8 | 647_845 | 0 | 311.0 | Domain | Rho-GAP |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000543210 | - | 1 | 8 | 91_284 | 0 | 311.0 | Domain | DH |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000544583 | - | 4 | 23 | 301_459 | 131 | 814.0 | Domain | PH |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000544583 | - | 4 | 23 | 484_613 | 131 | 814.0 | Domain | C2 |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000544583 | - | 4 | 23 | 647_845 | 131 | 814.0 | Domain | Rho-GAP |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000544583 | - | 4 | 23 | 91_284 | 131 | 814.0 | Domain | DH |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000574437 | - | 3 | 22 | 301_459 | 131 | 814.0 | Domain | PH |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000574437 | - | 3 | 22 | 484_613 | 131 | 814.0 | Domain | C2 |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000574437 | - | 3 | 22 | 647_845 | 131 | 814.0 | Domain | Rho-GAP |
| Hgene | ABR | chr17:994905 | chr17:1340449 | ENST00000574437 | - | 3 | 22 | 91_284 | 131 | 814.0 | Domain | DH |
| Tgene | CRK | chr17:994905 | chr17:1340449 | ENST00000300574 | 0 | 3 | 13_118 | 80 | 305.0 | Domain | SH2 | |
| Tgene | CRK | chr17:994905 | chr17:1340449 | ENST00000398970 | 0 | 3 | 13_118 | 80 | 205.0 | Domain | SH2 |
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Fusion Gene Sequence for ABR-CRK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >547_547_1_ABR-CRK_ABR_chr17_994905_ENST00000544583_CRK_chr17_1340449_ENST00000300574_length(transcript)=4491nt_BP=993nt GGACTGCAGAGGGAACTTGCCTTGAAGAGGCCTGGTCCTTAAAGAGACACAGCACACACGGCCCGACCGGCAGCCCCAGAGCAGAGGCTC CACTGATGGCAGGCGCCCCTGGCTAGGCTCTGAGGTTCCTTTGCCCTCGCCTTGCTGAATGGTGAGCCGCTGCCTCTCGGAGCCCGTCTC CTTGACAGCCTGCCCTCGGCTCCTGCAGCCACTCCTGGGCCTGATGGGGACAGGGCCAGCCTGGTGGGTGGTGTCAGAGGTCCTGGCAGA GCAGCGTAGGCCTGGGATGCGTCTGCAGAATTCTGGCTGAACGAGCGAGGAGCACGGCCAGCTTCGGGGCCGTCGTGACCACAGGAGGGC AGAGGGCCAGCCCGTGAGCTCTGACCCCAGCTGGACGTGCTCTTGTTTCCCTTGGGGCTAAGGAGATTGGAGCCACTGAACTGAATCTCT GGGTTTTGGAGACTTAGAGAATCCATTGGACTCTTCTGCTGGCGTCTTTCTGAATGCTGATGGGGACTTGGTGACTTCAGCTACGGGACG GACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATG TCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGG AAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCC ATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATC TATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAG CTGGGGTGAGCCCCTCCAGACTCCGAATAGGAGATCAAGAGTTTGATTCATTGCCTGCTTTACTGGAATTCTACAAAATACACTATTTGG ACACTACAACGTTGATAGAACCAGTTTCCAGATCCAGGCAGGGTAGTGGAGTGATTCTCAGGCAGGAGGAGGCGGAGTATGTGCGAGCCC TCTTTGACTTTAATGGGAATGATGAGGAAGATCTTCCCTTTAAGAAAGGAGACATCTTGAGAATCCGGGACAAGCCTGAAGAGCAGTGGT GGAATGCGGAGGACAGCGAAGGCAAGAGAGGGATGATTCCAGTCCCTTACGTCGAGAAGTATAGACCTGCCTCCGCCTCAGTATCGGCTC TGATTGGAGGTAACCAGGAGGGTTCCCACCCACAGCCACTGGGTGGGCCGGAGCCTGGGCCCTATGCCCAACCCAGCGTCAACACTCCGC TCCCTAACCTCCAGAATGGGCCCATATATGCCAGGGTTATCCAGAAGCGAGTCCCCAATGCCTACGACAAGACAGCCTTGGCTTTGGAGG TCGGTGAGCTGGTAAAGGTTACGAAGATTAATGTGAGTGGTCAGTGGGAAGGGGAGTGTAATGGCAAACGAGGTCACTTCCCATTCACAC ATGTCCGTCTGCTGGATCAACAGAATCCCGATGAGGACTTCAGCTGAGTATAGTTCAACAGTTTTGCTGACAGATGGGAACAATCTTTTT TTTTTTTTTCCAACTGCCATCTATACAATTTTCTTACAGATGTCAAAAGCAGTCTAGTTTATATAAGCATTCTGTTACCTGTGATATTTT TTAGACTGAACTGCTCCATTCCTAGTCTTAATTACCATATTCAGGGTACGAACTGGAGGGCTTGTGTGTTAGCTTCTGAATTGGCAATTG GAGGCGGTAGTGGTCGTGCCTGTGTGTATCAGAAGGGATAGGTATCTTGCCTCCTTTCTCTCAGGCAGTGCAAATCACCCTGTGGAAAAC CGATGGACAGGAAGGAGTGTTACACACTGCTTACCCTGATTTATTCAGTGGTTTTGTTTTCATTCTGGAACCATACTATCAAATGGCGAC AGACTGTTCCGTTCCACCCCCGTGAAGTAATCATGCACCGTGTGAATAGTATCAAGCAGGATTGCTTTCATTGTATGGAGCATGACCAGC GTGTGACTCATTCTGACATTTCAGATCCTAAGAATTCTAAGAACACTACTAGAAGCATTTGTTCCCTCCTAGTCAATGCTTCATACTTTT TCTTGGGATTCTTTTAGCCCTTGACATTCTTGTCCCCCAAACCTGTAAGTAGGTGAATTCCTAAGATAAGTGTGTATTTTCATTCCAGGT GAAAAGCAGGATGTACCGAGCACTTTATTCAGTGCATAGCTTTAAGCCAGTGTTGGATTCACTAAGTGGACAGCCAGTCTCCCAGCTCTC TGCCTTCCCCAAAAGGGTCGTAGTAGGTCACCCTTCTACAGCAGCTAACTAGAGTCCTAACTAATGGGATCCAGCAGGGCCATTTCTCCA GAGGGCCAGTATCCTATTAGGAGACTCTTGGAATTCTTAGGTTCTACTCAAGAGTGGAAGGACCAATCACCTCTGATATTCTGTGGAAGG TTTTGGGGTCAAATTCTGCCCTCTGCATTCTGTGCAACTTGTATAAAAGTCAAGTTAGTATTACATGAATTTGGGGTAGGGTTAGTGCTT TGAAAAAATGTTGAACCGGCTGGGCGCGGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCATGAGGTCAGG AGTTCGAGACCAGCCTGGCCAACATAGTGAAACCCCATCTCTGCTAAAGATATAAAAAATTAGCCCGGCGTGGTGGTGCACGCCTGTAAT CCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTCAACCTGGGAGGTGGAGGCTGCAGTGAGCCGAGATCGCACCACTGCGTTCCAG CCTGAGCGACAGGGCAAGACTCAGTCTCAAAAAAAAAAAAAAGGAAAAAAAAAAGAAAAAAAAATGTTGAACCAATTGTGAATTACTTAT GTATTATTCATTTCTCATGGGGAGAGTAATGCTGTTGAAGAACATTACATTGTAAACTGCCTTCATTTTTGGCTCTTTGTTTATGTTCAG GTTTAGTTTACAAACCCATTTAAGTATGGAATGATTTATATGGGGTCAGGTGCTCCACAAAATAGACCTATGAGACCAAAAATGACCTAG GCTATTTAGACGACAGCATGAAACTTCCACGTTAGTTCTCAGTCTATAAAGGCACTTACCGGTCTCTGGTGTGGTATGACCAATAGAAAC ACCTTATAGTTTGCTTTGGACCTCATTTTGGAAAAATAATCTGCCTTTCTAATTGTTCTGCATAGGTTAAAATGATAAATTTACATTCTT TGAACCTATACCAGATTGTGGTGTCCGAGTGACCGGCACACTGTCTGACACACAGTCAGTGTGCACGTATTTGTCTGAGTGAATGAGGAG ACCTGAGAAACCGGTGACGTGGCACAGGGAAGCCAGCTGGCCCAGGATTCCGTACATGGCCGCAAGCAGACTAACGCGTTGACGCTAATT TAATGTATTTTACCTCACACTAAGGTCATGCTTGATAAAGACGTTAAACTCAACTTGTAAAATGGTAGCCCAGTGCTATGCACAGAGTGG GTGCTCATTAGTGTTGAATGAACACATTTGTAATACTACATGTAATTCCATCTGACTGCTTTGTTAAATTTTCAGTTAGAACGTAGATAC TGTAAAGTCCACACACACATTAAATCTTGTTTTCCTGAAAGTATGGCATCAAAAATACTTGTAGAAAAACCTTGTCACAACTGATTTGAA TGTTCCTATTTTCTTTTCCTTTGACTTTGATATTGGCTTGTAATGTCTCTTTTCATCATATGTAATATCAGTGGAACAGGCAGCGCTACT CAAGTCCTAAGGATTCCTCAGTGATCAGTGATCCAGGGCCGTTCATGAACCACTGGGCTGGATTTGACTGTTGAGTGTGGCAGTTAATGC CCCTCAAGAAATCAAAGGATGTCTTATAAGTGTCTTCCAAAAAAAAGCAAATGCTGAAATCCTATTGGCAAAGTAAACTGAAATTGGCTG CTATATTTTATATAATCATTTCTGCAAATCCCATTTTTTGAATACTAATATTTGACATGGTTAATTCTTATTAATTTGTTGGAATTGTTT ATTGTTAATAATGCAAATAGATAATTTTTAATTATCCACAAGTAACATTTCACTGTTAATGGTTTGAAATAGGTGATAAGCAAACCAATT TGAAATAAAATATAAACATGTGCCATTGTATTATAACACTATACACTTTCTTGACAGTTAAATTTAAAAAAAAATTTTTTTTGGTAGCAT >547_547_1_ABR-CRK_ABR_chr17_994905_ENST00000544583_CRK_chr17_1340449_ENST00000300574_length(amino acids)=208AA_BP= MPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPY VEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWE -------------------------------------------------------------- >547_547_2_ABR-CRK_ABR_chr17_994905_ENST00000544583_CRK_chr17_1340449_ENST00000398970_length(transcript)=4321nt_BP=993nt GGACTGCAGAGGGAACTTGCCTTGAAGAGGCCTGGTCCTTAAAGAGACACAGCACACACGGCCCGACCGGCAGCCCCAGAGCAGAGGCTC CACTGATGGCAGGCGCCCCTGGCTAGGCTCTGAGGTTCCTTTGCCCTCGCCTTGCTGAATGGTGAGCCGCTGCCTCTCGGAGCCCGTCTC CTTGACAGCCTGCCCTCGGCTCCTGCAGCCACTCCTGGGCCTGATGGGGACAGGGCCAGCCTGGTGGGTGGTGTCAGAGGTCCTGGCAGA GCAGCGTAGGCCTGGGATGCGTCTGCAGAATTCTGGCTGAACGAGCGAGGAGCACGGCCAGCTTCGGGGCCGTCGTGACCACAGGAGGGC AGAGGGCCAGCCCGTGAGCTCTGACCCCAGCTGGACGTGCTCTTGTTTCCCTTGGGGCTAAGGAGATTGGAGCCACTGAACTGAATCTCT GGGTTTTGGAGACTTAGAGAATCCATTGGACTCTTCTGCTGGCGTCTTTCTGAATGCTGATGGGGACTTGGTGACTTCAGCTACGGGACG GACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATG TCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGG AAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCC ATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATC TATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAG CTGGGGTGAGCCCCTCCAGACTCCGAATAGGAGATCAAGAGTTTGATTCATTGCCTGCTTTACTGGAATTCTACAAAATACACTATTTGG ACACTACAACGTTGATAGAACCAGTTTCCAGATCCAGGCAGGGTAGTGGAGTGATTCTCAGGCAGGAGGAGGCGGAGTATGTGCGAGCCC TCTTTGACTTTAATGGGAATGATGAGGAAGATCTTCCCTTTAAGAAAGGAGACATCTTGAGAATCCGGGACAAGCCTGAAGAGCAGTGGT GGAATGCGGAGGACAGCGAAGGCAAGAGAGGGATGATTCCAGTCCCTTACGTCGAGAAGTATAGACCTGCCTCCGCCTCAGTATCGGCTC TGATTGGAGGTCGGTGAGCTGGTAAAGGTTACGAAGATTAATGTGAGTGGTCAGTGGGAAGGGGAGTGTAATGGCAAACGAGGTCACTTC CCATTCACACATGTCCGTCTGCTGGATCAACAGAATCCCGATGAGGACTTCAGCTGAGTATAGTTCAACAGTTTTGCTGACAGATGGGAA CAATCTTTTTTTTTTTTTTCCAACTGCCATCTATACAATTTTCTTACAGATGTCAAAAGCAGTCTAGTTTATATAAGCATTCTGTTACCT GTGATATTTTTTAGACTGAACTGCTCCATTCCTAGTCTTAATTACCATATTCAGGGTACGAACTGGAGGGCTTGTGTGTTAGCTTCTGAA TTGGCAATTGGAGGCGGTAGTGGTCGTGCCTGTGTGTATCAGAAGGGATAGGTATCTTGCCTCCTTTCTCTCAGGCAGTGCAAATCACCC TGTGGAAAACCGATGGACAGGAAGGAGTGTTACACACTGCTTACCCTGATTTATTCAGTGGTTTTGTTTTCATTCTGGAACCATACTATC AAATGGCGACAGACTGTTCCGTTCCACCCCCGTGAAGTAATCATGCACCGTGTGAATAGTATCAAGCAGGATTGCTTTCATTGTATGGAG CATGACCAGCGTGTGACTCATTCTGACATTTCAGATCCTAAGAATTCTAAGAACACTACTAGAAGCATTTGTTCCCTCCTAGTCAATGCT TCATACTTTTTCTTGGGATTCTTTTAGCCCTTGACATTCTTGTCCCCCAAACCTGTAAGTAGGTGAATTCCTAAGATAAGTGTGTATTTT CATTCCAGGTGAAAAGCAGGATGTACCGAGCACTTTATTCAGTGCATAGCTTTAAGCCAGTGTTGGATTCACTAAGTGGACAGCCAGTCT CCCAGCTCTCTGCCTTCCCCAAAAGGGTCGTAGTAGGTCACCCTTCTACAGCAGCTAACTAGAGTCCTAACTAATGGGATCCAGCAGGGC CATTTCTCCAGAGGGCCAGTATCCTATTAGGAGACTCTTGGAATTCTTAGGTTCTACTCAAGAGTGGAAGGACCAATCACCTCTGATATT CTGTGGAAGGTTTTGGGGTCAAATTCTGCCCTCTGCATTCTGTGCAACTTGTATAAAAGTCAAGTTAGTATTACATGAATTTGGGGTAGG GTTAGTGCTTTGAAAAAATGTTGAACCGGCTGGGCGCGGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCA TGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAACCCCATCTCTGCTAAAGATATAAAAAATTAGCCCGGCGTGGTGGTGCA CGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTCAACCTGGGAGGTGGAGGCTGCAGTGAGCCGAGATCGCACCAC TGCGTTCCAGCCTGAGCGACAGGGCAAGACTCAGTCTCAAAAAAAAAAAAAAGGAAAAAAAAAAGAAAAAAAAATGTTGAACCAATTGTG AATTACTTATGTATTATTCATTTCTCATGGGGAGAGTAATGCTGTTGAAGAACATTACATTGTAAACTGCCTTCATTTTTGGCTCTTTGT TTATGTTCAGGTTTAGTTTACAAACCCATTTAAGTATGGAATGATTTATATGGGGTCAGGTGCTCCACAAAATAGACCTATGAGACCAAA AATGACCTAGGCTATTTAGACGACAGCATGAAACTTCCACGTTAGTTCTCAGTCTATAAAGGCACTTACCGGTCTCTGGTGTGGTATGAC CAATAGAAACACCTTATAGTTTGCTTTGGACCTCATTTTGGAAAAATAATCTGCCTTTCTAATTGTTCTGCATAGGTTAAAATGATAAAT TTACATTCTTTGAACCTATACCAGATTGTGGTGTCCGAGTGACCGGCACACTGTCTGACACACAGTCAGTGTGCACGTATTTGTCTGAGT GAATGAGGAGACCTGAGAAACCGGTGACGTGGCACAGGGAAGCCAGCTGGCCCAGGATTCCGTACATGGCCGCAAGCAGACTAACGCGTT GACGCTAATTTAATGTATTTTACCTCACACTAAGGTCATGCTTGATAAAGACGTTAAACTCAACTTGTAAAATGGTAGCCCAGTGCTATG CACAGAGTGGGTGCTCATTAGTGTTGAATGAACACATTTGTAATACTACATGTAATTCCATCTGACTGCTTTGTTAAATTTTCAGTTAGA ACGTAGATACTGTAAAGTCCACACACACATTAAATCTTGTTTTCCTGAAAGTATGGCATCAAAAATACTTGTAGAAAAACCTTGTCACAA CTGATTTGAATGTTCCTATTTTCTTTTCCTTTGACTTTGATATTGGCTTGTAATGTCTCTTTTCATCATATGTAATATCAGTGGAACAGG CAGCGCTACTCAAGTCCTAAGGATTCCTCAGTGATCAGTGATCCAGGGCCGTTCATGAACCACTGGGCTGGATTTGACTGTTGAGTGTGG CAGTTAATGCCCCTCAAGAAATCAAAGGATGTCTTATAAGTGTCTTCCAAAAAAAAGCAAATGCTGAAATCCTATTGGCAAAGTAAACTG AAATTGGCTGCTATATTTTATATAATCATTTCTGCAAATCCCATTTTTTGAATACTAATATTTGACATGGTTAATTCTTATTAATTTGTT GGAATTGTTTATTGTTAATAATGCAAATAGATAATTTTTAATTATCCACAAGTAACATTTCACTGTTAATGGTTTGAAATAGGTGATAAG CAAACCAATTTGAAATAAAATATAAACATGTGCCATTGTATTATAACACTATACACTTTCTTGACAGTTAAATTTAAAAAAAAATTTTTT TTGGTAGCATGTATTGTATATGTTTATAGTATATGTAGTAAATAAAAATATGGCCAAATGTTTGGCTTGGTGATCTTTTGCAAAAAAGTA >547_547_2_ABR-CRK_ABR_chr17_994905_ENST00000544583_CRK_chr17_1340449_ENST00000398970_length(amino acids)=149AA_BP=0 MNQTLDLLFGVWRGSPQLLEEVAHGDLAVPLLHLGAQVVIELLVDLIDVLDLVEDGLDLLDGEHGLGGGGGGLQGFHGQQQGFQLVNVDL -------------------------------------------------------------- >547_547_3_ABR-CRK_ABR_chr17_994905_ENST00000544583_CRK_chr17_1340449_ENST00000574295_length(transcript)=2111nt_BP=993nt GGACTGCAGAGGGAACTTGCCTTGAAGAGGCCTGGTCCTTAAAGAGACACAGCACACACGGCCCGACCGGCAGCCCCAGAGCAGAGGCTC CACTGATGGCAGGCGCCCCTGGCTAGGCTCTGAGGTTCCTTTGCCCTCGCCTTGCTGAATGGTGAGCCGCTGCCTCTCGGAGCCCGTCTC CTTGACAGCCTGCCCTCGGCTCCTGCAGCCACTCCTGGGCCTGATGGGGACAGGGCCAGCCTGGTGGGTGGTGTCAGAGGTCCTGGCAGA GCAGCGTAGGCCTGGGATGCGTCTGCAGAATTCTGGCTGAACGAGCGAGGAGCACGGCCAGCTTCGGGGCCGTCGTGACCACAGGAGGGC AGAGGGCCAGCCCGTGAGCTCTGACCCCAGCTGGACGTGCTCTTGTTTCCCTTGGGGCTAAGGAGATTGGAGCCACTGAACTGAATCTCT GGGTTTTGGAGACTTAGAGAATCCATTGGACTCTTCTGCTGGCGTCTTTCTGAATGCTGATGGGGACTTGGTGACTTCAGCTACGGGACG GACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATG TCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGG AAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCC ATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATC TATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAG CTGGGGTGAGCCCCTCCAGACTCCGAATAGGAGATCAAGAGTTTGATTCATTGCCTGCTTTACTGGAATTCTACAAAATACACTATTTGG ACACTACAACGTTGATAGAACCAGTTTCCAGATCCAGGCAGGGTAGTGGAGTGATTCTCAGGCAGGAGGAGGAGTGTTACACACTGCTTA CCCTGATTTATTCAGTGGTTTTGTTTTCATTCTGGAACCATACTATCAAATGGCGACAGACTGTTCCGTTCCACCCCCGTGAAGTAATCA TGCACCGTGTGAATAGTATCAAGCAGGATTGCTTTCATTGTATGGAGCATGACCAGCGTGTGACTCATTCTGACATTTCAGATCCTAAGA ATTCTAAGAACACTACTAGAAGCATTTGTTCCCTCCTAGTCAATGCTTCATACTTTTTCTTGGGATTCTTTTAGCCCTTGACATTCTTGT CCCCCAAACCTGTAAGTAGGTGAATTCCTAAGATAAGTGTGTATTTTCATTCCAGGTGAAAAGCAGGATGTACCGAGCACTTTATTCAGT GCATAGCTTTAAGCCAGTGTTGGATTCACTAAGTGGACAGCCAGTCTCCCAGCTCTCTGCCTTCCCCAAAAGGGTCGTAGTAGGTCACCC TTCTACAGCAGCTAACTAGAGTCCTAACTAATGGGATCCAGCAGGGCCATTTCTCCAGAGGGCCAGTATCCTATTAGGAGACTCTTGGAA TTCTTAGGTTCTACTCAAGAGTGGAAGGACCAATCACCTCTGATATTCTGTGGAAGGTTTTGGGGTCAAATTCTGCCCTCTGCATTCTGT GCAACTTGTATAAAAGTCAAGTTAGTATTACATGAATTTGGGGTAGGGTTAGTGCTTTGAAAAAATGTTGAACCGGCTGGGCGCGGTGGC TCACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCATGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAAC CCCATCTCTGCTAAAGATATAAAAAATTAGCCCGGCGTGGTGGTGCACGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATT >547_547_3_ABR-CRK_ABR_chr17_994905_ENST00000544583_CRK_chr17_1340449_ENST00000574295_length(amino acids)=163AA_BP= MKSPSPHQHSERRQQKSPMDSLSLQNPEIQFSGSNLLSPKGNKSTSSWGQSSRAGPLPSCGHDGPEAGRAPRSFSQNSADASQAYAALPG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ABR-CRK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ABR-CRK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ABR-CRK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ABR | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | ABR | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| Tgene | C0151744 | Myocardial Ischemia | 1 | CTD_human |
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