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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABR-RTN4RL1 (FusionGDB2 ID:HG29TG146760)

Fusion Gene Summary for ABR-RTN4RL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ABR-RTN4RL1
Fusion gene ID: hg29tg146760
HgeneTgene
Gene symbol

ABR

RTN4RL1

Gene ID

29

146760

Gene nameABR activator of RhoGEF and GTPasereticulon 4 receptor like 1
SynonymsMDBNGRH2|NgR3
Cytomap('ABR')('RTN4RL1')

17p13.3

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionactive breakpoint cluster region-related proteinABR, RhoGEF and GTPase activating proteinactive BCR-relatedreticulon-4 receptor-like 1Nogo-66 receptor homolog 2Nogo-66 receptor-related protein 3nogo receptor-like 2
Modification date2020031320200313
UniProtAcc

Q12979

.
Ensembl transtripts involved in fusion geneENST00000291107, ENST00000302538, 
ENST00000536794, ENST00000574437, 
ENST00000544583, ENST00000543210, 
ENST00000572441, ENST00000573895, 
Fusion gene scores* DoF score23 X 15 X 14=48307 X 2 X 8=112
# samples 3610
** MAII scorelog2(36/4830*10)=-3.74595437739346
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/112*10)=-0.163498732282879
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABR [Title/Abstract] AND RTN4RL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABR(970317)-RTN4RL1(1841102), # samples:1
Anticipated loss of major functional domain due to fusion event.ABR-RTN4RL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABR-RTN4RL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABR-RTN4RL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABR-RTN4RL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABR-RTN4RL1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ABR-RTN4RL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABR

GO:0090630

activation of GTPase activity

7479768


check buttonFusion gene breakpoints across ABR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RTN4RL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GU-A42P-01AABRchr17

970317

-RTN4RL1chr17

1841102

-


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Fusion Gene ORF analysis for ABR-RTN4RL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000291107ENST00000331238ABRchr17

970317

-RTN4RL1chr17

1841102

-
Frame-shiftENST00000302538ENST00000331238ABRchr17

970317

-RTN4RL1chr17

1841102

-
Frame-shiftENST00000536794ENST00000331238ABRchr17

970317

-RTN4RL1chr17

1841102

-
Frame-shiftENST00000574437ENST00000331238ABRchr17

970317

-RTN4RL1chr17

1841102

-
In-frameENST00000544583ENST00000331238ABRchr17

970317

-RTN4RL1chr17

1841102

-
intron-3CDSENST00000543210ENST00000331238ABRchr17

970317

-RTN4RL1chr17

1841102

-
intron-3CDSENST00000572441ENST00000331238ABRchr17

970317

-RTN4RL1chr17

1841102

-
intron-3CDSENST00000573895ENST00000331238ABRchr17

970317

-RTN4RL1chr17

1841102

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000544583ABRchr17970317-ENST00000331238RTN4RL1chr171841102-4776164425661250438

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544583ENST00000331238ABRchr17970317-RTN4RL1chr171841102-0.153816920.84618306

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Fusion Genomic Features for ABR-RTN4RL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ABR-RTN4RL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:970317/chr17:1841102)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABR

Q12979

.
FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). {ECO:0000250|UniProtKB:Q5SSL4, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:7479768}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABRchr17:970317chr17:1841102ENST00000291107-92291_284357823.0DomainDH
HgeneABRchr17:970317chr17:1841102ENST00000302538-102391_284394860.0DomainDH
HgeneABRchr17:970317chr17:1841102ENST00000544583-102391_284348814.0DomainDH
HgeneABRchr17:970317chr17:1841102ENST00000574437-92291_284348814.0DomainDH
TgeneRTN4RL1chr17:970317chr17:1841102ENST0000033123802255_3064442.0DomainNote=LRRCT
TgeneRTN4RL1chr17:970317chr17:1841102ENST000003312380225_544442.0DomainNote=LRRNT
TgeneRTN4RL1chr17:970317chr17:1841102ENST0000033123802101_1234442.0RepeatNote=LRR 3
TgeneRTN4RL1chr17:970317chr17:1841102ENST0000033123802126_1474442.0RepeatNote=LRR 4
TgeneRTN4RL1chr17:970317chr17:1841102ENST0000033123802150_1714442.0RepeatNote=LRR 5
TgeneRTN4RL1chr17:970317chr17:1841102ENST0000033123802174_1954442.0RepeatNote=LRR 6
TgeneRTN4RL1chr17:970317chr17:1841102ENST0000033123802198_2194442.0RepeatNote=LRR 7
TgeneRTN4RL1chr17:970317chr17:1841102ENST0000033123802222_2434442.0RepeatNote=LRR 8
TgeneRTN4RL1chr17:970317chr17:1841102ENST000003312380255_764442.0RepeatNote=LRR 1
TgeneRTN4RL1chr17:970317chr17:1841102ENST000003312380277_984442.0RepeatNote=LRR 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABRchr17:970317chr17:1841102ENST00000291107-922417_420357823.0Compositional biasNote=Poly-Leu
HgeneABRchr17:970317chr17:1841102ENST00000302538-1023417_420394860.0Compositional biasNote=Poly-Leu
HgeneABRchr17:970317chr17:1841102ENST00000543210-18417_4200311.0Compositional biasNote=Poly-Leu
HgeneABRchr17:970317chr17:1841102ENST00000544583-1023417_420348814.0Compositional biasNote=Poly-Leu
HgeneABRchr17:970317chr17:1841102ENST00000574437-922417_420348814.0Compositional biasNote=Poly-Leu
HgeneABRchr17:970317chr17:1841102ENST00000291107-922301_459357823.0DomainPH
HgeneABRchr17:970317chr17:1841102ENST00000291107-922484_613357823.0DomainC2
HgeneABRchr17:970317chr17:1841102ENST00000291107-922647_845357823.0DomainRho-GAP
HgeneABRchr17:970317chr17:1841102ENST00000302538-1023301_459394860.0DomainPH
HgeneABRchr17:970317chr17:1841102ENST00000302538-1023484_613394860.0DomainC2
HgeneABRchr17:970317chr17:1841102ENST00000302538-1023647_845394860.0DomainRho-GAP
HgeneABRchr17:970317chr17:1841102ENST00000543210-18301_4590311.0DomainPH
HgeneABRchr17:970317chr17:1841102ENST00000543210-18484_6130311.0DomainC2
HgeneABRchr17:970317chr17:1841102ENST00000543210-18647_8450311.0DomainRho-GAP
HgeneABRchr17:970317chr17:1841102ENST00000543210-1891_2840311.0DomainDH
HgeneABRchr17:970317chr17:1841102ENST00000544583-1023301_459348814.0DomainPH
HgeneABRchr17:970317chr17:1841102ENST00000544583-1023484_613348814.0DomainC2
HgeneABRchr17:970317chr17:1841102ENST00000544583-1023647_845348814.0DomainRho-GAP
HgeneABRchr17:970317chr17:1841102ENST00000574437-922301_459348814.0DomainPH
HgeneABRchr17:970317chr17:1841102ENST00000574437-922484_613348814.0DomainC2
HgeneABRchr17:970317chr17:1841102ENST00000574437-922647_845348814.0DomainRho-GAP


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Fusion Gene Sequence for ABR-RTN4RL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>559_559_1_ABR-RTN4RL1_ABR_chr17_970317_ENST00000544583_RTN4RL1_chr17_1841102_ENST00000331238_length(transcript)=4776nt_BP=1644nt
GGACTGCAGAGGGAACTTGCCTTGAAGAGGCCTGGTCCTTAAAGAGACACAGCACACACGGCCCGACCGGCAGCCCCAGAGCAGAGGCTC
CACTGATGGCAGGCGCCCCTGGCTAGGCTCTGAGGTTCCTTTGCCCTCGCCTTGCTGAATGGTGAGCCGCTGCCTCTCGGAGCCCGTCTC
CTTGACAGCCTGCCCTCGGCTCCTGCAGCCACTCCTGGGCCTGATGGGGACAGGGCCAGCCTGGTGGGTGGTGTCAGAGGTCCTGGCAGA
GCAGCGTAGGCCTGGGATGCGTCTGCAGAATTCTGGCTGAACGAGCGAGGAGCACGGCCAGCTTCGGGGCCGTCGTGACCACAGGAGGGC
AGAGGGCCAGCCCGTGAGCTCTGACCCCAGCTGGACGTGCTCTTGTTTCCCTTGGGGCTAAGGAGATTGGAGCCACTGAACTGAATCTCT
GGGTTTTGGAGACTTAGAGAATCCATTGGACTCTTCTGCTGGCGTCTTTCTGAATGCTGATGGGGACTTGGTGACTTCAGCTACGGGACG
GACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATG
TCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGG
AAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCC
ATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATC
TATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAG
CTGGCCAGCCAGCTCGGTGTGTACAAAGCGTTTGTCGATAACTATAAAGTCGCTCTGGAGACAGCTGAGAAGTGCAGCCAGTCCAACAAC
CAGTTCCAGAAGATCTCAGAGGAACTCAAAGTGAAAGGTCCCAAGGACTCCAAGGACAGCCACACGTCTGTCACCATGGAAGCTCTGCTC
TACAAGCCCATTGACCGGGTCACTCGGAGCACCCTAGTCCTACACGACCTGCTGAAGCACACACCTGTGGACCACCCCGACTACCCGCTG
CTGCAGGATGCCCTCCGCATCTCCCAGAACTTCCTGTCCAGCATCAACGAGGACATCGACCCCCGCCGGACTGCAGTGACAACGCCCAAG
GGGGAGACGCGACAGCTGGTGAAGGACGGCTTCCTGGTGGAAGTGTCAGAGAGCTCCCGGAAGCTGCGGCACGTCTTCCTCTTTACAGAT
GTCCTACTGTGTGCCAAGCTGAAGAAGACCTCTGCAGGGAAGCACCAGCAGTATGACTGTAAGTGGTACATCCCCCTGGCCGACCTGGTG
TTTCCATCCCCCGAGGAGTCTGAGGCCAGCCCCCAGGTGCACCCCTTCCCAGACCATGAGCTGGAGGACATGAAGATGAAGATCTCTGCC
CTCAAGAGTGAAATCCAGAAGGAGGGTGCTGTGTGGAGTTGCTGCTGCTGTTGGTAGCTGCGGAGCTGCCCCTGGGTGGTGGCTGCCCAC
GGGACTGTGTGTGCTACCCGGCGCCCATGACGGTCAGCTGCCAGGCGCACAACTTTGCAGCCATCCCGGAGGGCATCCCCGTGGACAGCG
AGCGCGTCTTCCTGCAGAACAACCGCATCGGCCTCCTCCAGCCCGGCCACTTCAGCCCCGCCATGGTCACCCTGTGGATCTACTCGAACA
ACATCACCTACATCCACCCCAGCACCTTCGAGGGCTTCGTGCACCTGGAGGAGCTGGACCTCGGCGACAACCGGCAGCTGCGGACGCTGG
CACCCGAGACCTTCCAGGGCCTGGTGAAGCTTCACGCCCTCTACCTCTACAAGTGTGGGCTCAGCGCCTTGCCGGCCGGCGTCTTTGGCG
GCCTGCACAGCCTGCAGTACCTCTACCTGCAGGACAACCACATCGAGTACCTCCAGGACGACATCTTCGTGGACCTGGTCAACCTCAGCC
ACCTGTTTCTCCACGGCAACAAGCTGTGGAGTCTGGGCCCGGGCACCTTCCGGGGCCTGGTGAACCTGGACCGTCTTTTGCTGCACGAGA
ACCAGCTGCAGTGGGTCCACCACAAGGCGTTCCACGACCTCCGCAGGCTGACCACCCTCTTCCTCTTCAACAACAGCCTCTCGGAGCTGC
AGGGTGAGTGCCTGGCCCCGCTGGGGGCCCTGGAGTTCCTCCGCCTCAACGGCAACCCCTGGGACTGTGGTTGTCGCGCGCGCTCCCTGT
GGGAATGGCTGCAGAGGTTCCGGGGCTCCAGCTCCGCTGTCCCCTGTGTGTCCCCTGGGCTGCGGCACGGCCAGGACCTGAAGCTGCTGA
GGGCCGAGGACTTCCGGAACTGCACGGGACCAGCGTCCCCGCACCAGATCAAGTCACACACGCTCACCACCACCGACAGGGCCGCCCGCA
AGGAACACCACTCACCCCACGGCCCCACCAGGAGCAAGGGCCACCCGCACGGCCCCCGGCCCGGCCACAGGAAGCCGGGGAAGAACTGCA
CCAACCCCAGGAACCGCAATCAGATCTCTAAGGCGGGCGCCGGGAAACAGGCCCCCGAGCTGCCAGACTATGCCCCAGACTACCAGCACA
AGTTCAGTTTTGACATCATGCCTACGGCCCGGCCCAAGAGGAAGGGCAAGTGTGCCCGCAGGACCCCCATCCGTGCCCCCAGCGGGGTGC
AGCAGGCCTCCTCGGCCAGTTCCCTGGGGGCCTCCCTCCTGGCCTGGACACTGGGGCTGGCGGTCACTCTCCGCTGAGGACCCAGGGCGT
CAGCACCCAGCACTGCCACATGTCCACCAAGGAACAGAATTTATTTTCTTCTTTTTTTAACAAGTGGAAGATCTGCTGGGTTTCAGGAAA
AGGCTGGTAGAGCCTTCGGCTGCTGTCTGGACGTCTGGACCCTGCCATGTGGATTATAAACCCAAAGTGTACAGCCCTAGGCGGGAGGGG
GTGGCGCTTCTCAGCCGGCTGTCCCAGCCAGCCCCGCAGAGCGCCCACGGACAGTGTCCACTCTGGCAAGGTGGGAAAAGGCACTCCAAG
TGCATCCTCCACTGGCAACAGTGGGACAATTGCCCCCGACGGCGGCACCGGGGCTCTGTGGAATCCCGATCGTTCCGAGAGGTCTGGAGG
GCCCCGTGGTTCCTGGAGAAAGCAGGACGCAGAGAAGAACAAATGAGGCTCACCCACGAGGCTGGGTGGCCAGCAGTCTGGGCACACACG
AGCAGGTGGCATCTTGGCTCTTGCCTGAGGCCAGTCACCCTGCCCTGAATTCTATCCTACTCCACCTTCAGCCCCTCCCTCGGGGGTAGC
GCCTCTCATTCCTGATGTCTCAGGCAACCCTGGCAGACCCAGGTCCAACTGCTGGGGTCCAAGAACCAATTACCAAAGGAAAGATCATCA
GAGGCTGAAATCTAGAACTTCATCCCGGGCAATGAGGTTCTCACAGAAGGTGCAGTTTTATAACTAACTACGTCCACTTATATATATTCA
CACTCTACATATATATATATATATATATATATATATATATATATATATATACACAAATGCACAGTCCCCCTCCCACTCCGTTACCTAACT
GTACGTCTTTTCATGTTTATAAACTATACAGAAAACTGTATTTGCTGAACTAAGGATTGTATTGGTGATTTCTAGCAAAAACAAAGTGAT
AGAATTTTTGTCTAGAATCCCAAACTGGCAACGATAGTCTCCAAGGGACCTGGCCTTGCCAAGGGCCTGGGGCAAGGTGTCGGCGGGACG
GTGAGGAAGGGGGAGGCAGCAAGAGTCACTTTGGGGGACCAATATTCTTAGATATTTAGAGCATCACCTTGTTTTTATATGCAACACAAG
CCTGTCTGCCACCCTGGAGCGCCCTGTCACCCCTGCTGTCGTAGCTGTTGGCTTCAGGGTGAGAAGTGAGAAGCAGCTTATTGTATATGA
GGGAGCCAGGCCCCGAGGGTGAGCGAGATGGAGAAGGGGAAGGAAGGGGCTTTGGGATCTGGAAACCAGCAGGCCAGGCAGCATCCACAG
TGTTAGTCCAAAGGGTCGGACCGTGTCGTCAGCCTAGCGTTTGGTCAGTGACGGCCTGGACGGGCCAAGGAGACTCCGGGCTTGAGCCCA
GGCCTCCCGCACGGCTCAGCTGCTGAATTTTTCCTTGAGGCTGTTTGGTGTGTGACCCAGCAAGGGCCCTGTGTGGGACAGCAGGAGGGA
GGCGTCGGGGGCCTTAGCAGAAGGGGAACAATGAGGGCATTTCATGAACCATCTCAGGCACTTCTGCATCACGGAAGACCTGGCCCTCCC
AGCCGTCCTGGGGATGCTCAGGGTGCAGGCAGAGGCTCGGGAGGCCGGACTCAGGGGTCAGAAGCAGGGACTGGGGCAGGCGAGCCCGGA
CAGGGAAGAGGGGCTCCGATCAAAGCCGGCCGTGCTGCTGGCCGGGGGCCCAGGTGGGTACAAGCTCCTTTGTGCTTTGCACAAACCTGA
ATCCCCCACCAGAGAGGATGTGTGTGAGGAGCCAGAAACGCTGAATCCAATTAAGAGAGAAAAATAATAATAACAATAAATGATCTTGGA

>559_559_1_ABR-RTN4RL1_ABR_chr17_970317_ENST00000544583_RTN4RL1_chr17_1841102_ENST00000331238_length(amino acids)=438AA_BP=1
MVRGRWSRAVPEVLGPQQLQVLAVPQPRGHTGDSGAGAPEPLQPFPQGARATTTVPGVAVEAEELQGPQRGQALTLQLREAVVEEEEGGQ
PAEVVERLVVDPLQLVLVQQKTVQVHQAPEGARAQTPQLVAVEKQVAEVDQVHEDVVLEVLDVVVLQVEVLQAVQAAKDAGRQGAEPTLV
EVEGVKLHQALEGLGCQRPQLPVVAEVQLLQVHEALEGAGVDVGDVVRVDPQGDHGGAEVAGLEEADAVVLQEDALAVHGDALRDGCKVV
RLAADRHGRRVAHTVPWAATTQGQLRSYQQQQQLHTAPSFWISLLRAEIFIFMSSSSWSGKGCTWGLASDSSGDGNTRSARGMYHLQSYC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ABR-RTN4RL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABR-RTN4RL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABR-RTN4RL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABRC0033578Prostatic Neoplasms1CTD_human
HgeneABRC0376358Malignant neoplasm of prostate1CTD_human