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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABR-MAN2B1 (FusionGDB2 ID:HG29TG4125)

Fusion Gene Summary for ABR-MAN2B1

check button Fusion gene summary
Fusion gene informationFusion gene name: ABR-MAN2B1
Fusion gene ID: hg29tg4125
HgeneTgene
Gene symbol

ABR

MAN2B1

Gene ID

29

4125

Gene nameABR activator of RhoGEF and GTPasemannosidase alpha class 2B member 1
SynonymsMDBLAMAN|MANB
Cytomap('ABR')('MAN2B1')

17p13.3

19p13.13

Type of geneprotein-codingprotein-coding
Descriptionactive breakpoint cluster region-related proteinABR, RhoGEF and GTPase activating proteinactive BCR-relatedlysosomal alpha-mannosidaselysosomal acid alpha-mannosidasemannosidase alpha-Bmannosidase, alpha B, lysosomal
Modification date2020031320200313
UniProtAcc

Q12979

.
Ensembl transtripts involved in fusion geneENST00000291107, ENST00000302538, 
ENST00000544583, ENST00000574437, 
ENST00000536794, ENST00000543210, 
ENST00000572441, ENST00000573895, 
Fusion gene scores* DoF score23 X 15 X 14=48308 X 10 X 5=400
# samples 369
** MAII scorelog2(36/4830*10)=-3.74595437739346
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/400*10)=-2.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABR [Title/Abstract] AND MAN2B1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABR(994905)-MAN2B1(12776619), # samples:3
Anticipated loss of major functional domain due to fusion event.ABR-MAN2B1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABR-MAN2B1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABR-MAN2B1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ABR-MAN2B1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABR

GO:0090630

activation of GTPase activity

7479768

TgeneMAN2B1

GO:0006464

cellular protein modification process

8910458


check buttonFusion gene breakpoints across ABR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MAN2B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-6402-01AABRchr17

994905

-MAN2B1chr19

12776619

-
ChimerDB4LGGTCGA-DU-6402ABRchr17

994905

-MAN2B1chr19

12776619

-


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Fusion Gene ORF analysis for ABR-MAN2B1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000291107ENST00000495617ABRchr17

994905

-MAN2B1chr19

12776619

-
5CDS-intronENST00000302538ENST00000495617ABRchr17

994905

-MAN2B1chr19

12776619

-
5CDS-intronENST00000544583ENST00000495617ABRchr17

994905

-MAN2B1chr19

12776619

-
5CDS-intronENST00000574437ENST00000495617ABRchr17

994905

-MAN2B1chr19

12776619

-
Frame-shiftENST00000544583ENST00000221363ABRchr17

994905

-MAN2B1chr19

12776619

-
Frame-shiftENST00000544583ENST00000456935ABRchr17

994905

-MAN2B1chr19

12776619

-
In-frameENST00000291107ENST00000221363ABRchr17

994905

-MAN2B1chr19

12776619

-
In-frameENST00000291107ENST00000456935ABRchr17

994905

-MAN2B1chr19

12776619

-
In-frameENST00000302538ENST00000221363ABRchr17

994905

-MAN2B1chr19

12776619

-
In-frameENST00000302538ENST00000456935ABRchr17

994905

-MAN2B1chr19

12776619

-
In-frameENST00000574437ENST00000221363ABRchr17

994905

-MAN2B1chr19

12776619

-
In-frameENST00000574437ENST00000456935ABRchr17

994905

-MAN2B1chr19

12776619

-
intron-3CDSENST00000536794ENST00000221363ABRchr17

994905

-MAN2B1chr19

12776619

-
intron-3CDSENST00000536794ENST00000456935ABRchr17

994905

-MAN2B1chr19

12776619

-
intron-3CDSENST00000543210ENST00000221363ABRchr17

994905

-MAN2B1chr19

12776619

-
intron-3CDSENST00000543210ENST00000456935ABRchr17

994905

-MAN2B1chr19

12776619

-
intron-3CDSENST00000572441ENST00000221363ABRchr17

994905

-MAN2B1chr19

12776619

-
intron-3CDSENST00000572441ENST00000456935ABRchr17

994905

-MAN2B1chr19

12776619

-
intron-3CDSENST00000573895ENST00000221363ABRchr17

994905

-MAN2B1chr19

12776619

-
intron-3CDSENST00000573895ENST00000456935ABRchr17

994905

-MAN2B1chr19

12776619

-
intron-intronENST00000536794ENST00000495617ABRchr17

994905

-MAN2B1chr19

12776619

-
intron-intronENST00000543210ENST00000495617ABRchr17

994905

-MAN2B1chr19

12776619

-
intron-intronENST00000572441ENST00000495617ABRchr17

994905

-MAN2B1chr19

12776619

-
intron-intronENST00000573895ENST00000495617ABRchr17

994905

-MAN2B1chr19

12776619

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000302538ABRchr17994905-ENST00000456935MAN2B1chr1912776619-366267814735541135
ENST00000302538ABRchr17994905-ENST00000221363MAN2B1chr1912776619-365667814735511134
ENST00000574437ABRchr17994905-ENST00000456935MAN2B1chr1912776619-384285812337341203
ENST00000574437ABRchr17994905-ENST00000221363MAN2B1chr1912776619-383685812337311202
ENST00000291107ABRchr17994905-ENST00000456935MAN2B1chr1912776619-34364523233281098
ENST00000291107ABRchr17994905-ENST00000221363MAN2B1chr1912776619-34304523233251097

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000302538ENST00000456935ABRchr17994905-MAN2B1chr1912776619-0.0025045720.9974954
ENST00000302538ENST00000221363ABRchr17994905-MAN2B1chr1912776619-0.0029524790.9970475
ENST00000574437ENST00000456935ABRchr17994905-MAN2B1chr1912776619-0.0030411320.99695885
ENST00000574437ENST00000221363ABRchr17994905-MAN2B1chr1912776619-0.0035265360.9964735
ENST00000291107ENST00000456935ABRchr17994905-MAN2B1chr1912776619-0.0020432630.99795675
ENST00000291107ENST00000221363ABRchr17994905-MAN2B1chr1912776619-0.0023916960.9976083

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Fusion Genomic Features for ABR-MAN2B1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ABR-MAN2B1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:994905/chr19:12776619)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABR

Q12979

.
FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). {ECO:0000250|UniProtKB:Q5SSL4, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:7479768}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABRchr17:994905chr19:12776619ENST00000291107-322417_420140823.0Compositional biasNote=Poly-Leu
HgeneABRchr17:994905chr19:12776619ENST00000302538-423417_420177860.0Compositional biasNote=Poly-Leu
HgeneABRchr17:994905chr19:12776619ENST00000543210-18417_4200311.0Compositional biasNote=Poly-Leu
HgeneABRchr17:994905chr19:12776619ENST00000544583-423417_420131814.0Compositional biasNote=Poly-Leu
HgeneABRchr17:994905chr19:12776619ENST00000574437-322417_420131814.0Compositional biasNote=Poly-Leu
HgeneABRchr17:994905chr19:12776619ENST00000291107-322301_459140823.0DomainPH
HgeneABRchr17:994905chr19:12776619ENST00000291107-322484_613140823.0DomainC2
HgeneABRchr17:994905chr19:12776619ENST00000291107-322647_845140823.0DomainRho-GAP
HgeneABRchr17:994905chr19:12776619ENST00000291107-32291_284140823.0DomainDH
HgeneABRchr17:994905chr19:12776619ENST00000302538-423301_459177860.0DomainPH
HgeneABRchr17:994905chr19:12776619ENST00000302538-423484_613177860.0DomainC2
HgeneABRchr17:994905chr19:12776619ENST00000302538-423647_845177860.0DomainRho-GAP
HgeneABRchr17:994905chr19:12776619ENST00000302538-42391_284177860.0DomainDH
HgeneABRchr17:994905chr19:12776619ENST00000543210-18301_4590311.0DomainPH
HgeneABRchr17:994905chr19:12776619ENST00000543210-18484_6130311.0DomainC2
HgeneABRchr17:994905chr19:12776619ENST00000543210-18647_8450311.0DomainRho-GAP
HgeneABRchr17:994905chr19:12776619ENST00000543210-1891_2840311.0DomainDH
HgeneABRchr17:994905chr19:12776619ENST00000544583-423301_459131814.0DomainPH
HgeneABRchr17:994905chr19:12776619ENST00000544583-423484_613131814.0DomainC2
HgeneABRchr17:994905chr19:12776619ENST00000544583-423647_845131814.0DomainRho-GAP
HgeneABRchr17:994905chr19:12776619ENST00000544583-42391_284131814.0DomainDH
HgeneABRchr17:994905chr19:12776619ENST00000574437-322301_459131814.0DomainPH
HgeneABRchr17:994905chr19:12776619ENST00000574437-322484_613131814.0DomainC2
HgeneABRchr17:994905chr19:12776619ENST00000574437-322647_845131814.0DomainRho-GAP
HgeneABRchr17:994905chr19:12776619ENST00000574437-32291_284131814.0DomainDH


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Fusion Gene Sequence for ABR-MAN2B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>554_554_1_ABR-MAN2B1_ABR_chr17_994905_ENST00000291107_MAN2B1_chr19_12776619_ENST00000221363_length(transcript)=3430nt_BP=452nt
TTCCTGTCTGCCCTCCGCGGGCTCCGGCTGCCATGGAGGAGGAAGAGGAGGCGATAGGCTTGCTGGACAAGGTTCTGGAGGACGAAGATG
TGTTTCTCCTGGAGGAGTGCGAGCTGGGAACCCCGACCAGCCCCGGCTCAGGGTCCCCCTTCCTGGTGGCTGTGAAGGTGGAAGCAGGGA
AAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCCA
TGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATCT
ATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAGC
TGACATGCCCCACAGTGCAGCCGAACATGCTGAACGTGCACCTGCTGCCTCACACACATGATGACGTGGGCTGGCTCAAAACCGTGGACC
AGTACTTTTATGGAATCAAGAATGACATCCAGCACGCCGGTGTGCAGTACATCCTGGACTCGGTCATCTCTGCCTTGCTGGCAGATCCCA
CCCGTCGCTTCATTTACGTGGAGATTGCCTTCTTCTCCCGTTGGTGGCACCAGCAGACAAATGCCACACAGGAAGTCGTGCGAGACCTTG
TGCGCCAGGGGCGCCTGGAGTTCGCCAATGGTGGCTGGGTGATGAACGATGAGGCAGCCACCCACTACGGTGCCATCGTGGACCAGATGA
CACTTGGGCTGCGCTTTCTGGAGGACACATTTGGCAATGATGGGCGACCCCGTGTGGCCTGGCACATTGACCCCTTCGGCCACTCTCGGG
AGCAGGCCTCGCTGTTTGCGCAGATGGGCTTCGACGGCTTCTTCTTTGGGCGCCTTGATTATCAAGATAAGTGGGTACGGATGCAGAAGC
TGGAGATGGAGCAGGTGTGGCGGGCCAGCACCAGCCTGAAGCCCCCGACCGCGGACCTCTTCACTGGTGTGCTTCCCAATGGTTACAACC
CGCCAAGGAATCTGTGCTGGGATGTGCTGTGTGTCGATCAGCCGCTGGTGGAGGACCCTCGCAGCCCCGAGTACAACGCCAAGGAGCTGG
TCGATTACTTCCTAAATGTGGCCACTGCCCAGGGCCGGTATTACCGCACCAACCACACTGTGATGACCATGGGCTCGGACTTCCAATATG
AGAATGCCAACATGTGGTTCAAGAACCTTGACAAGCTCATCCGGCTGGTAAATGCGCAGGCAAAAGGAAGCAGTGTCCATGTTCTCTACT
CCACCCCCGCTTGTTACCTCTGGGAGCTGAACAAGGCCAACCTCACCTGGTCAGTGAAACATGACGACTTCTTCCCTTACGCGGATGGCC
CCCACCAGTTCTGGACCGGTTACTTTTCCAGTCGGCCGGCCCTCAAACGCTACGAGCGCCTCAGCTACAACTTCCTGCAGGTGTGCAACC
AGCTGGAGGCGCTGGTGGGCCTGGCGGCCAACGTGGGACCCTATGGCTCCGGAGACAGTGCACCCCTCAATGAGGCGATGGCTGTGCTCC
AGCATCACGACGCCGTCAGCGGCACCTCCCGCCAGCACGTGGCCAACGACTACGCGCGCCAGCTTGCGGCAGGCTGGGGGCCTTGCGAGG
TTCTTCTGAGCAACGCGCTGGCGCGGCTCAGAGGCTTCAAAGATCACTTCACCTTTTGCCAACAGCTAAACATCAGCATCTGCCCGCTCA
GCCAGACGGCGGCGCGCTTCCAGGTCATCGTTTATAATCCCCTGGGGCGGAAGGTGAATTGGATGGTACGGCTGCCGGTCAGCGAAGGCG
TTTTCGTTGTGAAGGACCCCAATGGCAGGACAGTGCCCAGCGATGTGGTAATATTTCCCAGCTCAGACAGCCAGGCGCACCCTCCGGAGC
TGCTGTTCTCAGCCTCACTGCCCGCCCTGGGCTTCAGCACCTATTCAGTAGCCCAGGTGCCTCGCTGGAAGCCCCAGGCCCGCGCACCAC
AGCCCATCCCCAGAAGATCCTGGTCCCCTGCTTTAACCATCGAAAATGAGCACATCCGGGCAACGTTTGATCCTGACACAGGGCTGTTGA
TGGAGATTATGAACATGAATCAGCAACTCCTGCTGCCTGTTCGCCAGACCTTCTTCTGGTACAACGCCAGTATAGGTGACAACGAAAGTG
ACCAGGCCTCAGGTGCCTACATCTTCAGACCCAACCAACAGAAACCGCTGCCTGTGAGCCGCTGGGCTCAGATCCACCTGGTGAAGACAC
CCTTGGTGCAGGAGGTGCACCAGAACTTCTCAGCTTGGTGTTCCCAGGTGGTTCGCCTGTACCCAGGACAGCGGCACCTGGAGCTAGAGT
GGTCGGTGGGGCCGATACCTGTGGGCGACACCTGGGGGAAGGAGGTCATCAGCCGTTTTGACACACCGCTGGAGACAAAGGGACGCTTCT
ACACAGACAGCAATGGCCGGGAGATCCTGGAGAGGAGGCGGGATTATCGACCCACCTGGAAACTGAACCAGACGGAGCCCGTGGCAGGAA
ACTACTATCCAGTCAACACCCGGATTTACATCACGGATGGAAACATGCAGCTGACTGTGCTGACTGACCGCTCCCAGGGGGGCAGCAGCC
TGAGAGATGGCTCGCTGGAGCTCATGGTGCACCGAAGGCTGCTGAAGGACGATGGACGCGGAGTATCGGAGCCACTAATGGAGAACGGGT
CGGGGGCGTGGGTGCGAGGGCGCCACCTGGTGCTGCTGGACACAGCCCAGGCTGCAGCCGCCGGACACCGGCTCCTGGCGGAGCAGGAGG
TCCTGGCCCCTCAGGTGGTGCTGGCCCCGGGTGGCGGCGCCGCCTACAATCTCGGGGCTCCTCCGCGCACGCAGTTCTCAGGGCTGCGCA
GGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGGGGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCAGTTTGCCGTAG
GAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAACTTGAGGGACCTGTTCTCCACCTTCACCATCACCCGCCTGCAGGAGA
CCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAACAAACACAGGCCCCACACCCCACCAAACTCCGTACC
AGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGATGGTTAGGTCT
GCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCAGACCAGACTCTGACTCTCCTCTTGGGGCTGCTGCCATTAAAACGCT

>554_554_1_ABR-MAN2B1_ABR_chr17_994905_ENST00000291107_MAN2B1_chr19_12776619_ENST00000221363_length(amino acids)=1097AA_BP=140
MEEEEEAIGLLDKVLEDEDVFLLEECELGTPTSPGSGSPFLVAVKVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTS
QPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLTCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQ
HAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTF
GNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLC
VDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQAKGSSVHVLYSTPACYLWELN
KANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSR
QHVANDYARQLAAGWGPCEVLLSNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDPNGRT
VPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLL
LPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDT
WGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVH
RRLLKDDGRGVSEPLMENGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLLT
LASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPTPHQTPYQLDPANITLEP

--------------------------------------------------------------
>554_554_2_ABR-MAN2B1_ABR_chr17_994905_ENST00000291107_MAN2B1_chr19_12776619_ENST00000456935_length(transcript)=3436nt_BP=452nt
TTCCTGTCTGCCCTCCGCGGGCTCCGGCTGCCATGGAGGAGGAAGAGGAGGCGATAGGCTTGCTGGACAAGGTTCTGGAGGACGAAGATG
TGTTTCTCCTGGAGGAGTGCGAGCTGGGAACCCCGACCAGCCCCGGCTCAGGGTCCCCCTTCCTGGTGGCTGTGAAGGTGGAAGCAGGGA
AAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCCA
TGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATCT
ATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAGC
TGACATGCCCCACAGTGCAGCCGAACATGCTGAACGTGCACCTGCTGCCTCACACACATGATGACGTGGGCTGGCTCAAAACCGTGGACC
AGTACTTTTATGGAATCAAGAATGACATCCAGCACGCCGGTGTGCAGTACATCCTGGACTCGGTCATCTCTGCCTTGCTGGCAGATCCCA
CCCGTCGCTTCATTTACGTGGAGATTGCCTTCTTCTCCCGTTGGTGGCACCAGCAGACAAATGCCACACAGGAAGTCGTGCGAGACCTTG
TGCGCCAGGGGCGCCTGGAGTTCGCCAATGGTGGCTGGGTGATGAACGATGAGGCAGCCACCCACTACGGTGCCATCGTGGACCAGATGA
CACTTGGGCTGCGCTTTCTGGAGGACACATTTGGCAATGATGGGCGACCCCGTGTGGCCTGGCACATTGACCCCTTCGGCCACTCTCGGG
AGCAGGCCTCGCTGTTTGCGCAGATGGGCTTCGACGGCTTCTTCTTTGGGCGCCTTGATTATCAAGATAAGTGGGTACGGATGCAGAAGC
TGGAGATGGAGCAGGTGTGGCGGGCCAGCACCAGCCTGAAGCCCCCGACCGCGGACCTCTTCACTGGTGTGCTTCCCAATGGTTACAACC
CGCCAAGGAATCTGTGCTGGGATGTGCTGTGTGTCGATCAGCCGCTGGTGGAGGACCCTCGCAGCCCCGAGTACAACGCCAAGGAGCTGG
TCGATTACTTCCTAAATGTGGCCACTGCCCAGGGCCGGTATTACCGCACCAACCACACTGTGATGACCATGGGCTCGGACTTCCAATATG
AGAATGCCAACATGTGGTTCAAGAACCTTGACAAGCTCATCCGGCTGGTAAATGCGCAGCAGGCAAAAGGAAGCAGTGTCCATGTTCTCT
ACTCCACCCCCGCTTGTTACCTCTGGGAGCTGAACAAGGCCAACCTCACCTGGTCAGTGAAACATGACGACTTCTTCCCTTACGCGGATG
GCCCCCACCAGTTCTGGACCGGTTACTTTTCCAGTCGGCCGGCCCTCAAACGCTACGAGCGCCTCAGCTACAACTTCCTGCAGGTGTGCA
ACCAGCTGGAGGCGCTGGTGGGCCTGGCGGCCAACGTGGGACCCTATGGCTCCGGAGACAGTGCACCCCTCAATGAGGCGATGGCTGTGC
TCCAGCATCACGACGCCGTCAGCGGCACCTCCCGCCAGCACGTGGCCAACGACTACGCGCGCCAGCTTGCGGCAGGCTGGGGGCCTTGCG
AGGTTCTTCTGAGCAACGCGCTGGCGCGGCTCAGAGGCTTCAAAGATCACTTCACCTTTTGCCAACAGCTAAACATCAGCATCTGCCCGC
TCAGCCAGACGGCGGCGCGCTTCCAGGTCATCGTTTATAATCCCCTGGGGCGGAAGGTGAATTGGATGGTACGGCTGCCGGTCAGCGAAG
GCGTTTTCGTTGTGAAGGACCCCAATGGCAGGACAGTGCCCAGCGATGTGGTAATATTTCCCAGCTCAGACAGCCAGGCGCACCCTCCGG
AGCTGCTGTTCTCAGCCTCACTGCCCGCCCTGGGCTTCAGCACCTATTCAGTAGCCCAGGTGCCTCGCTGGAAGCCCCAGGCCCGCGCAC
CACAGCCCATCCCCAGAAGATCCTGGTCCCCTGCTTTAACCATCGAAAATGAGCACATCCGGGCAACGTTTGATCCTGACACAGGGCTGT
TGATGGAGATTATGAACATGAATCAGCAACTCCTGCTGCCTGTTCGCCAGACCTTCTTCTGGTACAACGCCAGTATAGGTGACAACGAAA
GTGACCAGGCCTCAGGTGCCTACATCTTCAGACCCAACCAACAGAAACCGCTGCCTGTGAGCCGCTGGGCTCAGATCCACCTGGTGAAGA
CACCCTTGGTGCAGGAGGTGCACCAGAACTTCTCAGCTTGGTGTTCCCAGGTGGTTCGCCTGTACCCAGGACAGCGGCACCTGGAGCTAG
AGTGGTCGGTGGGGCCGATACCTGTGGGCGACACCTGGGGGAAGGAGGTCATCAGCCGTTTTGACACACCGCTGGAGACAAAGGGACGCT
TCTACACAGACAGCAATGGCCGGGAGATCCTGGAGAGGAGGCGGGATTATCGACCCACCTGGAAACTGAACCAGACGGAGCCCGTGGCAG
GAAACTACTATCCAGTCAACACCCGGATTTACATCACGGATGGAAACATGCAGCTGACTGTGCTGACTGACCGCTCCCAGGGGGGCAGCA
GCCTGAGAGATGGCTCGCTGGAGCTCATGGTGCACCGAAGGCTGCTGAAGGACGATGGACGCGGAGTATCGGAGCCACTAATGGAGAACG
GGTCGGGGGCGTGGGTGCGAGGGCGCCACCTGGTGCTGCTGGACACAGCCCAGGCTGCAGCCGCCGGACACCGGCTCCTGGCGGAGCAGG
AGGTCCTGGCCCCTCAGGTGGTGCTGGCCCCGGGTGGCGGCGCCGCCTACAATCTCGGGGCTCCTCCGCGCACGCAGTTCTCAGGGCTGC
GCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGGGGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCAGTTTGCCG
TAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAACTTGAGGGACCTGTTCTCCACCTTCACCATCACCCGCCTGCAGG
AGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAACAAACACAGGCCCCACACCCCACCAAACTCCGT
ACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGATGGTTAGG
TCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCAGACCAGACTCTGACTCTCCTCTTGGGGCTGCTGCCATTAAAAC

>554_554_2_ABR-MAN2B1_ABR_chr17_994905_ENST00000291107_MAN2B1_chr19_12776619_ENST00000456935_length(amino acids)=1098AA_BP=140
MEEEEEAIGLLDKVLEDEDVFLLEECELGTPTSPGSGSPFLVAVKVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTS
QPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLTCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQ
HAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTF
GNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLC
VDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYLWEL
NKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTS
RQHVANDYARQLAAGWGPCEVLLSNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDPNGR
TVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQL
LLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGD
TWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMV
HRRLLKDDGRGVSEPLMENGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLL
TLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPTPHQTPYQLDPANITLE

--------------------------------------------------------------
>554_554_3_ABR-MAN2B1_ABR_chr17_994905_ENST00000302538_MAN2B1_chr19_12776619_ENST00000221363_length(transcript)=3656nt_BP=678nt
GCCCCGCGCTCCTCCCGGGGACCTGGTTCCCGGCCTCCTCGCCCCTCCGCGCTCGCAACTTCGGCCTCCCCCGGCTCCCGCCCGCTCTCC
CTCCTTTGTTGCGCGATGAGGGTCGGGTTTCGGATCTGACCGAGCCGCCGCCGCGGGATGGAGCCGCTCAGCCACCGGGGCCTGCCGCGC
CTGTCCTGGATCGACACCCTCTACAGCAACTTCAGCTACGGGACGGACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCG
GAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATGTCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTC
TCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGGAAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCC
AGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCCATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTC
ACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATCTATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTG
CAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAGCTGACATGCCCCACAGTGCAGCCGAACATGCTGAACGTGCACCTG
CTGCCTCACACACATGATGACGTGGGCTGGCTCAAAACCGTGGACCAGTACTTTTATGGAATCAAGAATGACATCCAGCACGCCGGTGTG
CAGTACATCCTGGACTCGGTCATCTCTGCCTTGCTGGCAGATCCCACCCGTCGCTTCATTTACGTGGAGATTGCCTTCTTCTCCCGTTGG
TGGCACCAGCAGACAAATGCCACACAGGAAGTCGTGCGAGACCTTGTGCGCCAGGGGCGCCTGGAGTTCGCCAATGGTGGCTGGGTGATG
AACGATGAGGCAGCCACCCACTACGGTGCCATCGTGGACCAGATGACACTTGGGCTGCGCTTTCTGGAGGACACATTTGGCAATGATGGG
CGACCCCGTGTGGCCTGGCACATTGACCCCTTCGGCCACTCTCGGGAGCAGGCCTCGCTGTTTGCGCAGATGGGCTTCGACGGCTTCTTC
TTTGGGCGCCTTGATTATCAAGATAAGTGGGTACGGATGCAGAAGCTGGAGATGGAGCAGGTGTGGCGGGCCAGCACCAGCCTGAAGCCC
CCGACCGCGGACCTCTTCACTGGTGTGCTTCCCAATGGTTACAACCCGCCAAGGAATCTGTGCTGGGATGTGCTGTGTGTCGATCAGCCG
CTGGTGGAGGACCCTCGCAGCCCCGAGTACAACGCCAAGGAGCTGGTCGATTACTTCCTAAATGTGGCCACTGCCCAGGGCCGGTATTAC
CGCACCAACCACACTGTGATGACCATGGGCTCGGACTTCCAATATGAGAATGCCAACATGTGGTTCAAGAACCTTGACAAGCTCATCCGG
CTGGTAAATGCGCAGGCAAAAGGAAGCAGTGTCCATGTTCTCTACTCCACCCCCGCTTGTTACCTCTGGGAGCTGAACAAGGCCAACCTC
ACCTGGTCAGTGAAACATGACGACTTCTTCCCTTACGCGGATGGCCCCCACCAGTTCTGGACCGGTTACTTTTCCAGTCGGCCGGCCCTC
AAACGCTACGAGCGCCTCAGCTACAACTTCCTGCAGGTGTGCAACCAGCTGGAGGCGCTGGTGGGCCTGGCGGCCAACGTGGGACCCTAT
GGCTCCGGAGACAGTGCACCCCTCAATGAGGCGATGGCTGTGCTCCAGCATCACGACGCCGTCAGCGGCACCTCCCGCCAGCACGTGGCC
AACGACTACGCGCGCCAGCTTGCGGCAGGCTGGGGGCCTTGCGAGGTTCTTCTGAGCAACGCGCTGGCGCGGCTCAGAGGCTTCAAAGAT
CACTTCACCTTTTGCCAACAGCTAAACATCAGCATCTGCCCGCTCAGCCAGACGGCGGCGCGCTTCCAGGTCATCGTTTATAATCCCCTG
GGGCGGAAGGTGAATTGGATGGTACGGCTGCCGGTCAGCGAAGGCGTTTTCGTTGTGAAGGACCCCAATGGCAGGACAGTGCCCAGCGAT
GTGGTAATATTTCCCAGCTCAGACAGCCAGGCGCACCCTCCGGAGCTGCTGTTCTCAGCCTCACTGCCCGCCCTGGGCTTCAGCACCTAT
TCAGTAGCCCAGGTGCCTCGCTGGAAGCCCCAGGCCCGCGCACCACAGCCCATCCCCAGAAGATCCTGGTCCCCTGCTTTAACCATCGAA
AATGAGCACATCCGGGCAACGTTTGATCCTGACACAGGGCTGTTGATGGAGATTATGAACATGAATCAGCAACTCCTGCTGCCTGTTCGC
CAGACCTTCTTCTGGTACAACGCCAGTATAGGTGACAACGAAAGTGACCAGGCCTCAGGTGCCTACATCTTCAGACCCAACCAACAGAAA
CCGCTGCCTGTGAGCCGCTGGGCTCAGATCCACCTGGTGAAGACACCCTTGGTGCAGGAGGTGCACCAGAACTTCTCAGCTTGGTGTTCC
CAGGTGGTTCGCCTGTACCCAGGACAGCGGCACCTGGAGCTAGAGTGGTCGGTGGGGCCGATACCTGTGGGCGACACCTGGGGGAAGGAG
GTCATCAGCCGTTTTGACACACCGCTGGAGACAAAGGGACGCTTCTACACAGACAGCAATGGCCGGGAGATCCTGGAGAGGAGGCGGGAT
TATCGACCCACCTGGAAACTGAACCAGACGGAGCCCGTGGCAGGAAACTACTATCCAGTCAACACCCGGATTTACATCACGGATGGAAAC
ATGCAGCTGACTGTGCTGACTGACCGCTCCCAGGGGGGCAGCAGCCTGAGAGATGGCTCGCTGGAGCTCATGGTGCACCGAAGGCTGCTG
AAGGACGATGGACGCGGAGTATCGGAGCCACTAATGGAGAACGGGTCGGGGGCGTGGGTGCGAGGGCGCCACCTGGTGCTGCTGGACACA
GCCCAGGCTGCAGCCGCCGGACACCGGCTCCTGGCGGAGCAGGAGGTCCTGGCCCCTCAGGTGGTGCTGGCCCCGGGTGGCGGCGCCGCC
TACAATCTCGGGGCTCCTCCGCGCACGCAGTTCTCAGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGG
GGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCAGTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAAC
TTGAGGGACCTGTTCTCCACCTTCACCATCACCCGCCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTC
AAGTGGACAACAAACACAGGCCCCACACCCCACCAAACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGC
ACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGATGGTTAGGTCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCA

>554_554_3_ABR-MAN2B1_ABR_chr17_994905_ENST00000302538_MAN2B1_chr19_12776619_ENST00000221363_length(amino acids)=1134AA_BP=177
MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLE
MRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLTCP
TVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQG
RLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEME
QVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENAN
MWFKNLDKLIRLVNAQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEA
LVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNALARLRGFKDHFTFCQQLNISICPLSQTA
ARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIP
RRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQ
EVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYP
VNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAP
QVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLV

--------------------------------------------------------------
>554_554_4_ABR-MAN2B1_ABR_chr17_994905_ENST00000302538_MAN2B1_chr19_12776619_ENST00000456935_length(transcript)=3662nt_BP=678nt
GCCCCGCGCTCCTCCCGGGGACCTGGTTCCCGGCCTCCTCGCCCCTCCGCGCTCGCAACTTCGGCCTCCCCCGGCTCCCGCCCGCTCTCC
CTCCTTTGTTGCGCGATGAGGGTCGGGTTTCGGATCTGACCGAGCCGCCGCCGCGGGATGGAGCCGCTCAGCCACCGGGGCCTGCCGCGC
CTGTCCTGGATCGACACCCTCTACAGCAACTTCAGCTACGGGACGGACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCG
GAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATGTCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTC
TCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGGAAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCC
AGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCCATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTC
ACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATCTATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTG
CAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAGCTGACATGCCCCACAGTGCAGCCGAACATGCTGAACGTGCACCTG
CTGCCTCACACACATGATGACGTGGGCTGGCTCAAAACCGTGGACCAGTACTTTTATGGAATCAAGAATGACATCCAGCACGCCGGTGTG
CAGTACATCCTGGACTCGGTCATCTCTGCCTTGCTGGCAGATCCCACCCGTCGCTTCATTTACGTGGAGATTGCCTTCTTCTCCCGTTGG
TGGCACCAGCAGACAAATGCCACACAGGAAGTCGTGCGAGACCTTGTGCGCCAGGGGCGCCTGGAGTTCGCCAATGGTGGCTGGGTGATG
AACGATGAGGCAGCCACCCACTACGGTGCCATCGTGGACCAGATGACACTTGGGCTGCGCTTTCTGGAGGACACATTTGGCAATGATGGG
CGACCCCGTGTGGCCTGGCACATTGACCCCTTCGGCCACTCTCGGGAGCAGGCCTCGCTGTTTGCGCAGATGGGCTTCGACGGCTTCTTC
TTTGGGCGCCTTGATTATCAAGATAAGTGGGTACGGATGCAGAAGCTGGAGATGGAGCAGGTGTGGCGGGCCAGCACCAGCCTGAAGCCC
CCGACCGCGGACCTCTTCACTGGTGTGCTTCCCAATGGTTACAACCCGCCAAGGAATCTGTGCTGGGATGTGCTGTGTGTCGATCAGCCG
CTGGTGGAGGACCCTCGCAGCCCCGAGTACAACGCCAAGGAGCTGGTCGATTACTTCCTAAATGTGGCCACTGCCCAGGGCCGGTATTAC
CGCACCAACCACACTGTGATGACCATGGGCTCGGACTTCCAATATGAGAATGCCAACATGTGGTTCAAGAACCTTGACAAGCTCATCCGG
CTGGTAAATGCGCAGCAGGCAAAAGGAAGCAGTGTCCATGTTCTCTACTCCACCCCCGCTTGTTACCTCTGGGAGCTGAACAAGGCCAAC
CTCACCTGGTCAGTGAAACATGACGACTTCTTCCCTTACGCGGATGGCCCCCACCAGTTCTGGACCGGTTACTTTTCCAGTCGGCCGGCC
CTCAAACGCTACGAGCGCCTCAGCTACAACTTCCTGCAGGTGTGCAACCAGCTGGAGGCGCTGGTGGGCCTGGCGGCCAACGTGGGACCC
TATGGCTCCGGAGACAGTGCACCCCTCAATGAGGCGATGGCTGTGCTCCAGCATCACGACGCCGTCAGCGGCACCTCCCGCCAGCACGTG
GCCAACGACTACGCGCGCCAGCTTGCGGCAGGCTGGGGGCCTTGCGAGGTTCTTCTGAGCAACGCGCTGGCGCGGCTCAGAGGCTTCAAA
GATCACTTCACCTTTTGCCAACAGCTAAACATCAGCATCTGCCCGCTCAGCCAGACGGCGGCGCGCTTCCAGGTCATCGTTTATAATCCC
CTGGGGCGGAAGGTGAATTGGATGGTACGGCTGCCGGTCAGCGAAGGCGTTTTCGTTGTGAAGGACCCCAATGGCAGGACAGTGCCCAGC
GATGTGGTAATATTTCCCAGCTCAGACAGCCAGGCGCACCCTCCGGAGCTGCTGTTCTCAGCCTCACTGCCCGCCCTGGGCTTCAGCACC
TATTCAGTAGCCCAGGTGCCTCGCTGGAAGCCCCAGGCCCGCGCACCACAGCCCATCCCCAGAAGATCCTGGTCCCCTGCTTTAACCATC
GAAAATGAGCACATCCGGGCAACGTTTGATCCTGACACAGGGCTGTTGATGGAGATTATGAACATGAATCAGCAACTCCTGCTGCCTGTT
CGCCAGACCTTCTTCTGGTACAACGCCAGTATAGGTGACAACGAAAGTGACCAGGCCTCAGGTGCCTACATCTTCAGACCCAACCAACAG
AAACCGCTGCCTGTGAGCCGCTGGGCTCAGATCCACCTGGTGAAGACACCCTTGGTGCAGGAGGTGCACCAGAACTTCTCAGCTTGGTGT
TCCCAGGTGGTTCGCCTGTACCCAGGACAGCGGCACCTGGAGCTAGAGTGGTCGGTGGGGCCGATACCTGTGGGCGACACCTGGGGGAAG
GAGGTCATCAGCCGTTTTGACACACCGCTGGAGACAAAGGGACGCTTCTACACAGACAGCAATGGCCGGGAGATCCTGGAGAGGAGGCGG
GATTATCGACCCACCTGGAAACTGAACCAGACGGAGCCCGTGGCAGGAAACTACTATCCAGTCAACACCCGGATTTACATCACGGATGGA
AACATGCAGCTGACTGTGCTGACTGACCGCTCCCAGGGGGGCAGCAGCCTGAGAGATGGCTCGCTGGAGCTCATGGTGCACCGAAGGCTG
CTGAAGGACGATGGACGCGGAGTATCGGAGCCACTAATGGAGAACGGGTCGGGGGCGTGGGTGCGAGGGCGCCACCTGGTGCTGCTGGAC
ACAGCCCAGGCTGCAGCCGCCGGACACCGGCTCCTGGCGGAGCAGGAGGTCCTGGCCCCTCAGGTGGTGCTGGCCCCGGGTGGCGGCGCC
GCCTACAATCTCGGGGCTCCTCCGCGCACGCAGTTCTCAGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGC
TGGGGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCAGTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTG
AACTTGAGGGACCTGTTCTCCACCTTCACCATCACCCGCCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGG
CTCAAGTGGACAACAAACACAGGCCCCACACCCCACCAAACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATC
CGCACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGATGGTTAGGTCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGG

>554_554_4_ABR-MAN2B1_ABR_chr17_994905_ENST00000302538_MAN2B1_chr19_12776619_ENST00000456935_length(amino acids)=1135AA_BP=177
MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLE
MRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLTCP
TVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQG
RLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEME
QVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENAN
MWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLE
ALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNALARLRGFKDHFTFCQQLNISICPLSQT
AARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPI
PRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLV
QEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYY
PVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLA
PQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTL

--------------------------------------------------------------
>554_554_5_ABR-MAN2B1_ABR_chr17_994905_ENST00000574437_MAN2B1_chr19_12776619_ENST00000221363_length(transcript)=3836nt_BP=858nt
ATAAAAAGCAAAATGGTGACTCAGAGAGGAGAGTTGGAAGCGTCCTGCCTCTTGCTCCCACTGTTAATTTTTACACTTGGAATTAGGCAG
AAGGCAAAGAAAACAGCAGCTTGAAATACGCGGCTGACATGCTCTTCATCGGGTAGCAACAGCAGAGCCGCTCCTCCCCGCCTCCCAGCA
GCCCCGGAGCGGGCAGGGCCCGGTGCCTGCTGGCTCTCCCCCGCCCCTCACCAGGCCCAGGCCCCCGCACAGCCCCCGCCCGGGCCAGGC
GTGGATGGTGCGGCCGGGGCCATGGCTGCCGGGGGCCGCCGCCGGCGCCCACTACGCTACCAGTCCCTGGCAGCTCTGGTGGAGGATTCT
CAGTGGCCTTTCTTGTTCCTTGTCTCAGACTTCAGCTACGGGACGGACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCG
GAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATGTCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTC
TCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGGAAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCC
AGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCCATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTC
ACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATCTATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTG
CAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAGCTGACATGCCCCACAGTGCAGCCGAACATGCTGAACGTGCACCTG
CTGCCTCACACACATGATGACGTGGGCTGGCTCAAAACCGTGGACCAGTACTTTTATGGAATCAAGAATGACATCCAGCACGCCGGTGTG
CAGTACATCCTGGACTCGGTCATCTCTGCCTTGCTGGCAGATCCCACCCGTCGCTTCATTTACGTGGAGATTGCCTTCTTCTCCCGTTGG
TGGCACCAGCAGACAAATGCCACACAGGAAGTCGTGCGAGACCTTGTGCGCCAGGGGCGCCTGGAGTTCGCCAATGGTGGCTGGGTGATG
AACGATGAGGCAGCCACCCACTACGGTGCCATCGTGGACCAGATGACACTTGGGCTGCGCTTTCTGGAGGACACATTTGGCAATGATGGG
CGACCCCGTGTGGCCTGGCACATTGACCCCTTCGGCCACTCTCGGGAGCAGGCCTCGCTGTTTGCGCAGATGGGCTTCGACGGCTTCTTC
TTTGGGCGCCTTGATTATCAAGATAAGTGGGTACGGATGCAGAAGCTGGAGATGGAGCAGGTGTGGCGGGCCAGCACCAGCCTGAAGCCC
CCGACCGCGGACCTCTTCACTGGTGTGCTTCCCAATGGTTACAACCCGCCAAGGAATCTGTGCTGGGATGTGCTGTGTGTCGATCAGCCG
CTGGTGGAGGACCCTCGCAGCCCCGAGTACAACGCCAAGGAGCTGGTCGATTACTTCCTAAATGTGGCCACTGCCCAGGGCCGGTATTAC
CGCACCAACCACACTGTGATGACCATGGGCTCGGACTTCCAATATGAGAATGCCAACATGTGGTTCAAGAACCTTGACAAGCTCATCCGG
CTGGTAAATGCGCAGGCAAAAGGAAGCAGTGTCCATGTTCTCTACTCCACCCCCGCTTGTTACCTCTGGGAGCTGAACAAGGCCAACCTC
ACCTGGTCAGTGAAACATGACGACTTCTTCCCTTACGCGGATGGCCCCCACCAGTTCTGGACCGGTTACTTTTCCAGTCGGCCGGCCCTC
AAACGCTACGAGCGCCTCAGCTACAACTTCCTGCAGGTGTGCAACCAGCTGGAGGCGCTGGTGGGCCTGGCGGCCAACGTGGGACCCTAT
GGCTCCGGAGACAGTGCACCCCTCAATGAGGCGATGGCTGTGCTCCAGCATCACGACGCCGTCAGCGGCACCTCCCGCCAGCACGTGGCC
AACGACTACGCGCGCCAGCTTGCGGCAGGCTGGGGGCCTTGCGAGGTTCTTCTGAGCAACGCGCTGGCGCGGCTCAGAGGCTTCAAAGAT
CACTTCACCTTTTGCCAACAGCTAAACATCAGCATCTGCCCGCTCAGCCAGACGGCGGCGCGCTTCCAGGTCATCGTTTATAATCCCCTG
GGGCGGAAGGTGAATTGGATGGTACGGCTGCCGGTCAGCGAAGGCGTTTTCGTTGTGAAGGACCCCAATGGCAGGACAGTGCCCAGCGAT
GTGGTAATATTTCCCAGCTCAGACAGCCAGGCGCACCCTCCGGAGCTGCTGTTCTCAGCCTCACTGCCCGCCCTGGGCTTCAGCACCTAT
TCAGTAGCCCAGGTGCCTCGCTGGAAGCCCCAGGCCCGCGCACCACAGCCCATCCCCAGAAGATCCTGGTCCCCTGCTTTAACCATCGAA
AATGAGCACATCCGGGCAACGTTTGATCCTGACACAGGGCTGTTGATGGAGATTATGAACATGAATCAGCAACTCCTGCTGCCTGTTCGC
CAGACCTTCTTCTGGTACAACGCCAGTATAGGTGACAACGAAAGTGACCAGGCCTCAGGTGCCTACATCTTCAGACCCAACCAACAGAAA
CCGCTGCCTGTGAGCCGCTGGGCTCAGATCCACCTGGTGAAGACACCCTTGGTGCAGGAGGTGCACCAGAACTTCTCAGCTTGGTGTTCC
CAGGTGGTTCGCCTGTACCCAGGACAGCGGCACCTGGAGCTAGAGTGGTCGGTGGGGCCGATACCTGTGGGCGACACCTGGGGGAAGGAG
GTCATCAGCCGTTTTGACACACCGCTGGAGACAAAGGGACGCTTCTACACAGACAGCAATGGCCGGGAGATCCTGGAGAGGAGGCGGGAT
TATCGACCCACCTGGAAACTGAACCAGACGGAGCCCGTGGCAGGAAACTACTATCCAGTCAACACCCGGATTTACATCACGGATGGAAAC
ATGCAGCTGACTGTGCTGACTGACCGCTCCCAGGGGGGCAGCAGCCTGAGAGATGGCTCGCTGGAGCTCATGGTGCACCGAAGGCTGCTG
AAGGACGATGGACGCGGAGTATCGGAGCCACTAATGGAGAACGGGTCGGGGGCGTGGGTGCGAGGGCGCCACCTGGTGCTGCTGGACACA
GCCCAGGCTGCAGCCGCCGGACACCGGCTCCTGGCGGAGCAGGAGGTCCTGGCCCCTCAGGTGGTGCTGGCCCCGGGTGGCGGCGCCGCC
TACAATCTCGGGGCTCCTCCGCGCACGCAGTTCTCAGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGG
GGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCAGTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAAC
TTGAGGGACCTGTTCTCCACCTTCACCATCACCCGCCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTC
AAGTGGACAACAAACACAGGCCCCACACCCCACCAAACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGC
ACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGATGGTTAGGTCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCA

>554_554_5_ABR-MAN2B1_ABR_chr17_994905_ENST00000574437_MAN2B1_chr19_12776619_ENST00000221363_length(amino acids)=1202AA_BP=245
MTCSSSGSNSRAAPPRLPAAPERAGPGACWLSPAPHQAQAPAQPPPGPGVDGAAGAMAAGGRRRRPLRYQSLAALVEDSQWPFLFLVSDF
SYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEA
LLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLTCPTVQPNMLNVHLLPHTHDDVGWL
KTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAI
VDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLP
NGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQAKGSSV
HVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEA
MAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLP
VSEGVFVVKDPNGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPD
TGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRH
LELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQ
GGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQF
SGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPTPH

--------------------------------------------------------------
>554_554_6_ABR-MAN2B1_ABR_chr17_994905_ENST00000574437_MAN2B1_chr19_12776619_ENST00000456935_length(transcript)=3842nt_BP=858nt
ATAAAAAGCAAAATGGTGACTCAGAGAGGAGAGTTGGAAGCGTCCTGCCTCTTGCTCCCACTGTTAATTTTTACACTTGGAATTAGGCAG
AAGGCAAAGAAAACAGCAGCTTGAAATACGCGGCTGACATGCTCTTCATCGGGTAGCAACAGCAGAGCCGCTCCTCCCCGCCTCCCAGCA
GCCCCGGAGCGGGCAGGGCCCGGTGCCTGCTGGCTCTCCCCCGCCCCTCACCAGGCCCAGGCCCCCGCACAGCCCCCGCCCGGGCCAGGC
GTGGATGGTGCGGCCGGGGCCATGGCTGCCGGGGGCCGCCGCCGGCGCCCACTACGCTACCAGTCCCTGGCAGCTCTGGTGGAGGATTCT
CAGTGGCCTTTCTTGTTCCTTGTCTCAGACTTCAGCTACGGGACGGACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCG
GAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATGTCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTC
TCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGGAAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCC
AGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCCATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTC
ACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATCTATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTG
CAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAGCTGACATGCCCCACAGTGCAGCCGAACATGCTGAACGTGCACCTG
CTGCCTCACACACATGATGACGTGGGCTGGCTCAAAACCGTGGACCAGTACTTTTATGGAATCAAGAATGACATCCAGCACGCCGGTGTG
CAGTACATCCTGGACTCGGTCATCTCTGCCTTGCTGGCAGATCCCACCCGTCGCTTCATTTACGTGGAGATTGCCTTCTTCTCCCGTTGG
TGGCACCAGCAGACAAATGCCACACAGGAAGTCGTGCGAGACCTTGTGCGCCAGGGGCGCCTGGAGTTCGCCAATGGTGGCTGGGTGATG
AACGATGAGGCAGCCACCCACTACGGTGCCATCGTGGACCAGATGACACTTGGGCTGCGCTTTCTGGAGGACACATTTGGCAATGATGGG
CGACCCCGTGTGGCCTGGCACATTGACCCCTTCGGCCACTCTCGGGAGCAGGCCTCGCTGTTTGCGCAGATGGGCTTCGACGGCTTCTTC
TTTGGGCGCCTTGATTATCAAGATAAGTGGGTACGGATGCAGAAGCTGGAGATGGAGCAGGTGTGGCGGGCCAGCACCAGCCTGAAGCCC
CCGACCGCGGACCTCTTCACTGGTGTGCTTCCCAATGGTTACAACCCGCCAAGGAATCTGTGCTGGGATGTGCTGTGTGTCGATCAGCCG
CTGGTGGAGGACCCTCGCAGCCCCGAGTACAACGCCAAGGAGCTGGTCGATTACTTCCTAAATGTGGCCACTGCCCAGGGCCGGTATTAC
CGCACCAACCACACTGTGATGACCATGGGCTCGGACTTCCAATATGAGAATGCCAACATGTGGTTCAAGAACCTTGACAAGCTCATCCGG
CTGGTAAATGCGCAGCAGGCAAAAGGAAGCAGTGTCCATGTTCTCTACTCCACCCCCGCTTGTTACCTCTGGGAGCTGAACAAGGCCAAC
CTCACCTGGTCAGTGAAACATGACGACTTCTTCCCTTACGCGGATGGCCCCCACCAGTTCTGGACCGGTTACTTTTCCAGTCGGCCGGCC
CTCAAACGCTACGAGCGCCTCAGCTACAACTTCCTGCAGGTGTGCAACCAGCTGGAGGCGCTGGTGGGCCTGGCGGCCAACGTGGGACCC
TATGGCTCCGGAGACAGTGCACCCCTCAATGAGGCGATGGCTGTGCTCCAGCATCACGACGCCGTCAGCGGCACCTCCCGCCAGCACGTG
GCCAACGACTACGCGCGCCAGCTTGCGGCAGGCTGGGGGCCTTGCGAGGTTCTTCTGAGCAACGCGCTGGCGCGGCTCAGAGGCTTCAAA
GATCACTTCACCTTTTGCCAACAGCTAAACATCAGCATCTGCCCGCTCAGCCAGACGGCGGCGCGCTTCCAGGTCATCGTTTATAATCCC
CTGGGGCGGAAGGTGAATTGGATGGTACGGCTGCCGGTCAGCGAAGGCGTTTTCGTTGTGAAGGACCCCAATGGCAGGACAGTGCCCAGC
GATGTGGTAATATTTCCCAGCTCAGACAGCCAGGCGCACCCTCCGGAGCTGCTGTTCTCAGCCTCACTGCCCGCCCTGGGCTTCAGCACC
TATTCAGTAGCCCAGGTGCCTCGCTGGAAGCCCCAGGCCCGCGCACCACAGCCCATCCCCAGAAGATCCTGGTCCCCTGCTTTAACCATC
GAAAATGAGCACATCCGGGCAACGTTTGATCCTGACACAGGGCTGTTGATGGAGATTATGAACATGAATCAGCAACTCCTGCTGCCTGTT
CGCCAGACCTTCTTCTGGTACAACGCCAGTATAGGTGACAACGAAAGTGACCAGGCCTCAGGTGCCTACATCTTCAGACCCAACCAACAG
AAACCGCTGCCTGTGAGCCGCTGGGCTCAGATCCACCTGGTGAAGACACCCTTGGTGCAGGAGGTGCACCAGAACTTCTCAGCTTGGTGT
TCCCAGGTGGTTCGCCTGTACCCAGGACAGCGGCACCTGGAGCTAGAGTGGTCGGTGGGGCCGATACCTGTGGGCGACACCTGGGGGAAG
GAGGTCATCAGCCGTTTTGACACACCGCTGGAGACAAAGGGACGCTTCTACACAGACAGCAATGGCCGGGAGATCCTGGAGAGGAGGCGG
GATTATCGACCCACCTGGAAACTGAACCAGACGGAGCCCGTGGCAGGAAACTACTATCCAGTCAACACCCGGATTTACATCACGGATGGA
AACATGCAGCTGACTGTGCTGACTGACCGCTCCCAGGGGGGCAGCAGCCTGAGAGATGGCTCGCTGGAGCTCATGGTGCACCGAAGGCTG
CTGAAGGACGATGGACGCGGAGTATCGGAGCCACTAATGGAGAACGGGTCGGGGGCGTGGGTGCGAGGGCGCCACCTGGTGCTGCTGGAC
ACAGCCCAGGCTGCAGCCGCCGGACACCGGCTCCTGGCGGAGCAGGAGGTCCTGGCCCCTCAGGTGGTGCTGGCCCCGGGTGGCGGCGCC
GCCTACAATCTCGGGGCTCCTCCGCGCACGCAGTTCTCAGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGC
TGGGGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCAGTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTG
AACTTGAGGGACCTGTTCTCCACCTTCACCATCACCCGCCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGG
CTCAAGTGGACAACAAACACAGGCCCCACACCCCACCAAACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATC
CGCACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGATGGTTAGGTCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGG

>554_554_6_ABR-MAN2B1_ABR_chr17_994905_ENST00000574437_MAN2B1_chr19_12776619_ENST00000456935_length(amino acids)=1203AA_BP=245
MTCSSSGSNSRAAPPRLPAAPERAGPGACWLSPAPHQAQAPAQPPPGPGVDGAAGAMAAGGRRRRPLRYQSLAALVEDSQWPFLFLVSDF
SYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEA
LLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLTCPTVQPNMLNVHLLPHTHDDVGWL
KTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAI
VDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLP
NGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSS
VHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNE
AMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRL
PVSEGVFVVKDPNGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDP
DTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQR
HLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRS
QGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQ
FSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPTP

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Fusion Gene PPI Analysis for ABR-MAN2B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABR-MAN2B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABR-MAN2B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABRC0033578Prostatic Neoplasms1CTD_human
HgeneABRC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0024748alpha-Mannosidosis7CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0017661IGA Glomerulonephritis1CTD_human