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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABR-ACAD10 (FusionGDB2 ID:HG29TG80724)

Fusion Gene Summary for ABR-ACAD10

check button Fusion gene summary
Fusion gene informationFusion gene name: ABR-ACAD10
Fusion gene ID: hg29tg80724
HgeneTgene
Gene symbol

ABR

ACAD10

Gene ID

29

80724

Gene nameABR activator of RhoGEF and GTPaseacyl-CoA dehydrogenase family member 10
SynonymsMDB-
Cytomap('ABR')('ACAD10')

17p13.3

12q24.12

Type of geneprotein-codingprotein-coding
Descriptionactive breakpoint cluster region-related proteinABR, RhoGEF and GTPase activating proteinactive BCR-relatedacyl-CoA dehydrogenase family member 10ACAD-10acyl-Coenzyme A dehydrogenase family, member 10
Modification date2020031320200313
UniProtAcc

Q12979

Q6JQN1

Ensembl transtripts involved in fusion geneENST00000302538, ENST00000291107, 
ENST00000536794, ENST00000543210, 
ENST00000544583, ENST00000572441, 
ENST00000573895, ENST00000574437, 
Fusion gene scores* DoF score23 X 15 X 14=483011 X 12 X 9=1188
# samples 3613
** MAII scorelog2(36/4830*10)=-3.74595437739346
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1188*10)=-3.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABR [Title/Abstract] AND ACAD10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABR(1082961)-ACAD10(112191576), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABR

GO:0090630

activation of GTPase activity

7479768



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-A9SP-01AABRchr17

1082961

-ACAD10chr12

112191576

+
ChimerDB4BLCATCGA-XF-A9SPABRchr17

1082961

-ACAD10chr12

112191576

+


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Fusion Gene ORF analysis for ABR-ACAD10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000302538ENST00000313698ABRchr17

1082961

-ACAD10chr12

112191576

+
5CDS-intronENST00000302538ENST00000392636ABRchr17

1082961

-ACAD10chr12

112191576

+
5CDS-intronENST00000302538ENST00000413681ABRchr17

1082961

-ACAD10chr12

112191576

+
5CDS-intronENST00000302538ENST00000455480ABRchr17

1082961

-ACAD10chr12

112191576

+
5CDS-intronENST00000302538ENST00000549590ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000291107ENST00000313698ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000291107ENST00000392636ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000291107ENST00000413681ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000291107ENST00000455480ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000291107ENST00000549590ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000536794ENST00000313698ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000536794ENST00000392636ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000536794ENST00000413681ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000536794ENST00000455480ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000536794ENST00000549590ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000543210ENST00000313698ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000543210ENST00000392636ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000543210ENST00000413681ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000543210ENST00000455480ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000543210ENST00000549590ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000544583ENST00000313698ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000544583ENST00000392636ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000544583ENST00000413681ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000544583ENST00000455480ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000544583ENST00000549590ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000572441ENST00000313698ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000572441ENST00000392636ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000572441ENST00000413681ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000572441ENST00000455480ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000572441ENST00000549590ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000573895ENST00000313698ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000573895ENST00000392636ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000573895ENST00000413681ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000573895ENST00000455480ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000573895ENST00000549590ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000574437ENST00000313698ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000574437ENST00000392636ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000574437ENST00000413681ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000574437ENST00000455480ABRchr17

1082961

-ACAD10chr12

112191576

+
intron-intronENST00000574437ENST00000549590ABRchr17

1082961

-ACAD10chr12

112191576

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ABR-ACAD10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABRchr171082960-ACAD10chr12112191575+1.34E-111
ABRchr171082960-ACAD10chr12112191575+1.34E-111
ABRchr171082960-ACAD10chr12112191575+1.34E-111
ABRchr171082960-ACAD10chr12112191575+1.34E-111


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ABR-ACAD10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1082961/:112191576)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABR

Q12979

ACAD10

Q6JQN1

FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). {ECO:0000250|UniProtKB:Q5SSL4, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:7479768}.FUNCTION: Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA. {ECO:0000269|PubMed:21237683}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ABR-ACAD10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ABR-ACAD10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABR-ACAD10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABR-ACAD10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABRC0033578Prostatic Neoplasms1CTD_human
HgeneABRC0376358Malignant neoplasm of prostate1CTD_human