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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANXA4-SEC23A (FusionGDB2 ID:HG307TG10484)

Fusion Gene Summary for ANXA4-SEC23A

check button Fusion gene summary
Fusion gene informationFusion gene name: ANXA4-SEC23A
Fusion gene ID: hg307tg10484
HgeneTgene
Gene symbol

ANXA4

SEC23A

Gene ID

307

10484

Gene nameannexin A4Sec23 homolog A, COPII coat complex component
SynonymsANX4|HEL-S-274|P32.5|PAP-II|PIG28|PP4-X|ZAP36CLSD|hSec23A
Cytomap('ANXA4')('SEC23A')

2p13.3

14q21.1

Type of geneprotein-codingprotein-coding
Descriptionannexin A435-beta calcimedinannexin IV (placental anticoagulant protein II)annexin-4carbohydrate-binding protein p33/p41chromobindin-4endonexin Iepididymis secretory protein Li 274lipocortin IVplacental anticoagulant protein IIproliferation-induprotein transport protein Sec23ASEC23-related protein ASec23 homolog A, coat complex II component
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000394295, ENST00000409920, 
ENST00000536030, ENST00000418066, 
Fusion gene scores* DoF score14 X 12 X 7=11765 X 6 X 2=60
# samples 166
** MAII scorelog2(16/1176*10)=-2.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/60*10)=0
Context

PubMed: ANXA4 [Title/Abstract] AND SEC23A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANXA4(70033564)-SEC23A(39514528), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANXA4

GO:0006357

regulation of transcription by RNA polymerase II

20237821

HgeneANXA4

GO:0032088

negative regulation of NF-kappaB transcription factor activity

20237821

TgeneSEC23A

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


check buttonFusion gene breakpoints across ANXA4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SEC23A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8078-01AANXA4chr2

70033564

+SEC23Achr14

39514528

-


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Fusion Gene ORF analysis for ANXA4-SEC23A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000394295ENST00000548032ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5CDS-intronENST00000394295ENST00000553925ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5CDS-intronENST00000394295ENST00000553970ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5CDS-intronENST00000394295ENST00000557280ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5CDS-intronENST00000409920ENST00000548032ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5CDS-intronENST00000409920ENST00000553925ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5CDS-intronENST00000409920ENST00000553970ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5CDS-intronENST00000409920ENST00000557280ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5UTR-3CDSENST00000536030ENST00000307712ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5UTR-3CDSENST00000536030ENST00000536508ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5UTR-3CDSENST00000536030ENST00000537403ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5UTR-3CDSENST00000536030ENST00000545328ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5UTR-intronENST00000536030ENST00000548032ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5UTR-intronENST00000536030ENST00000553925ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5UTR-intronENST00000536030ENST00000553970ANXA4chr2

70033564

+SEC23Achr14

39514528

-
5UTR-intronENST00000536030ENST00000557280ANXA4chr2

70033564

+SEC23Achr14

39514528

-
In-frameENST00000394295ENST00000307712ANXA4chr2

70033564

+SEC23Achr14

39514528

-
In-frameENST00000394295ENST00000536508ANXA4chr2

70033564

+SEC23Achr14

39514528

-
In-frameENST00000394295ENST00000537403ANXA4chr2

70033564

+SEC23Achr14

39514528

-
In-frameENST00000394295ENST00000545328ANXA4chr2

70033564

+SEC23Achr14

39514528

-
In-frameENST00000409920ENST00000307712ANXA4chr2

70033564

+SEC23Achr14

39514528

-
In-frameENST00000409920ENST00000536508ANXA4chr2

70033564

+SEC23Achr14

39514528

-
In-frameENST00000409920ENST00000537403ANXA4chr2

70033564

+SEC23Achr14

39514528

-
In-frameENST00000409920ENST00000545328ANXA4chr2

70033564

+SEC23Achr14

39514528

-
intron-3CDSENST00000418066ENST00000307712ANXA4chr2

70033564

+SEC23Achr14

39514528

-
intron-3CDSENST00000418066ENST00000536508ANXA4chr2

70033564

+SEC23Achr14

39514528

-
intron-3CDSENST00000418066ENST00000537403ANXA4chr2

70033564

+SEC23Achr14

39514528

-
intron-3CDSENST00000418066ENST00000545328ANXA4chr2

70033564

+SEC23Achr14

39514528

-
intron-intronENST00000418066ENST00000548032ANXA4chr2

70033564

+SEC23Achr14

39514528

-
intron-intronENST00000418066ENST00000553925ANXA4chr2

70033564

+SEC23Achr14

39514528

-
intron-intronENST00000418066ENST00000553970ANXA4chr2

70033564

+SEC23Achr14

39514528

-
intron-intronENST00000418066ENST00000557280ANXA4chr2

70033564

+SEC23Achr14

39514528

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409920ANXA4chr270033564+ENST00000537403SEC23Achr1439514528-23694882481048266
ENST00000409920ANXA4chr270033564+ENST00000307712SEC23Achr1439514528-23684882481048266
ENST00000409920ANXA4chr270033564+ENST00000536508SEC23Achr1439514528-15414882481048266
ENST00000409920ANXA4chr270033564+ENST00000545328SEC23Achr1439514528-13474882481048266
ENST00000394295ANXA4chr270033564+ENST00000537403SEC23Achr1439514528-23875062481066272
ENST00000394295ANXA4chr270033564+ENST00000307712SEC23Achr1439514528-23865062481066272
ENST00000394295ANXA4chr270033564+ENST00000536508SEC23Achr1439514528-15595062481066272
ENST00000394295ANXA4chr270033564+ENST00000545328SEC23Achr1439514528-13655062481066272

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409920ENST00000537403ANXA4chr270033564+SEC23Achr1439514528-0.0003806660.99961936
ENST00000409920ENST00000307712ANXA4chr270033564+SEC23Achr1439514528-0.0003831620.99961686
ENST00000409920ENST00000536508ANXA4chr270033564+SEC23Achr1439514528-0.0010275090.99897254
ENST00000409920ENST00000545328ANXA4chr270033564+SEC23Achr1439514528-0.001525610.9984744
ENST00000394295ENST00000537403ANXA4chr270033564+SEC23Achr1439514528-0.000317710.9996823
ENST00000394295ENST00000307712ANXA4chr270033564+SEC23Achr1439514528-0.0003192470.99968076
ENST00000394295ENST00000536508ANXA4chr270033564+SEC23Achr1439514528-0.0009524830.99904746
ENST00000394295ENST00000545328ANXA4chr270033564+SEC23Achr1439514528-0.0014047180.9985953

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Fusion Genomic Features for ANXA4-SEC23A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ANXA4-SEC23A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:70033564/chr14:39514528)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSEC23Achr2:70033564chr14:39514528ENST000003077121420632_718579766.0RepeatGelsolin-like

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANXA4chr2:70033564chr14:39514528ENST00000394295+11314_850322.0RepeatAnnexin 1
HgeneANXA4chr2:70033564chr14:39514528ENST00000394295+113169_2410322.0RepeatAnnexin 3
HgeneANXA4chr2:70033564chr14:39514528ENST00000394295+113245_3160322.0RepeatAnnexin 4
HgeneANXA4chr2:70033564chr14:39514528ENST00000394295+11386_1570322.0RepeatAnnexin 2


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Fusion Gene Sequence for ANXA4-SEC23A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5065_5065_1_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000394295_SEC23A_chr14_39514528_ENST00000307712_length(transcript)=2386nt_BP=506nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGGCAACCAAAGGAG
GTACTGTCAAAGCTGCTTCAGGATTCAATGCCATGGAAGATGCCCAGACCCTGAGGAAGGCCATGAAAGGGCTCGGCACCGATGAAGACG
CCATTATTAGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGCACCATCGGCAGGGTGATTGTGG
GGATGATGACGCCCACGGTGCTGTATGACGTGCAAGAGCTGCGAAGGGCCATGAAGTTTATGTTTCATTTAAGAAGATCTTCTTTCCTGC
AAGTTTTTAACAATAGTCCTGATGAGAGTTCATATTATCGTCACCATTTTATGCGTCAAGATCTGACCCAGTCTCTAATTATGATTCAGC
CTATCCTGTATGCGTATTCTTTTAGTGGACCACCAGAGCCGGTTCTTCTTGATAGCAGTAGCATTCTTGCAGATCGTATTCTTCTCATGG
ACACATTCTTCCAGATTTTGATTTATCATGGTGAGACCATAGCACAGTGGCGGAAGTCAGGATACCAGGATATGCCTGAGTATGAAAATT
TCCGCCACCTTCTGCAAGCCCCAGTGGATGATGCACAGGAAATTCTTCACTCCAGATTTCCAATGCCAAGATACATTGACACTGAACATG
GAGGCAGCCAGGCCCGTTTCCTCCTTTCAAAAGTCAACCCTTCACAGACTCATAATAATATGTATGCCTGGGGGCAGGAGTCTGGAGCAC
CTATTCTTACAGATGATGTTAGTTTACAAGTGTTTATGGATCACTTGAAGAAACTTGCTGTGTCCAGTGCTGCTTGAAGTGCTAATAATG
TTAAAGACACTTAAGAAGATGAAATAATATTCAAATTTCATTTTTTCCTTTTTCCATTTATCTGTGGAAACCAACAGATATTGCTCTATA
TTTTTTGTATTAGTATGGTTTGAGACAACATATGGAAAATGTTCACATTTGTAGATTAAGCTGGAATTATAATGAGAGCAATAAGAACAA
ATTTATTTTGCTTACCACAGTGTTATAGCTGGTTCTAGAAATTTGAAGTCTTTATAACTTAATTATGTTTAATAAAAAATAGAGTCTGCC
TCGTACTACAGATGTAACTCATTTGTATATTGCAGACAGACCCAAAGTGGCACTGAATTTTCTTGCTCACCTTTTAAAAACTTGTTCCTT
AATTTTAGCCAGAAAGCAAAAAAACAATAGTAATGATAAATGTGAACATTTTTGCTTATTCATTGAATATTTTTCTGTAATTTTCAGCAC
TTATGTATACACTTTTTCTGTACTTACTAGGTTAAGGCAGATTTATTTTTATGATTTGTTTAGGAATTATTTGATTTTATAATGGTAATT
TTCATGATGATAATGTTTTTGGTTATTTGGAAAGATAGTTTAGAGATGAAAGGTTTTTTTGGGTAACAATCCCGCAGCTGACAAAAAATG
TGAAATTTCCACAAAATATCCAACTTATGTGACTAAACGCAGTAGTTTTTTTAAAAGGGGAGATAGAAAATAAATGGTTTTGTTGGAGTG
CATTTTAGTAAGCCTTTGCAGTAAAATGACGGTTGTAACTACTAAACCAAATTTAGTTTTCACAGCATGGTTTTGTTGTTTTCCCCTTGT
TTTTCAGAGGTAAATTTTGCATTATATCCTTCAGTATTTTAACACTATTTTGGCAGTTTACACATTACTTTTTGTTTTTCCTTCCTTTTT
GTGAAATGTATTAAGTTGTGGTTCTTATTGAAACAGTATTATATAATGTTTGCTTAATTATATCATGTGATGCTCAGTTCTATTTTGATT
TATTCATTAGTATTCACTTTTACCTTTAAAGTTTACTTGTAGCAAATATGTTTACATTGATAAAGCCAGATATGTTTTGACAATGAAATT
TACATATCAAGTACTGCAAATAAAAGGTGGTGCTATGATATATGCTTAGGAGGACAGTTTTAATGATTGTACTTGCATGAACACAATCAT
ATGATGGTAAAGCAGAAACTTAAGAAAAAATTGTTTATGTGTTATATTCAATTAGCTTAAATAAGTTGCTTTGTTATATTTTATTTGAAT
TGAACTACGCTAGGCCTAAATGCCAATAAAATATACTTTTCACTGT

>5065_5065_1_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000394295_SEC23A_chr14_39514528_ENST00000307712_length(amino acids)=272AA_BP=86
MAMATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRVIVGMMTPTVLYDVQELRRAMKFMFH
LRRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQ
DMPEYENFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKLAVSS
AA

--------------------------------------------------------------
>5065_5065_2_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000394295_SEC23A_chr14_39514528_ENST00000536508_length(transcript)=1559nt_BP=506nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGGCAACCAAAGGAG
GTACTGTCAAAGCTGCTTCAGGATTCAATGCCATGGAAGATGCCCAGACCCTGAGGAAGGCCATGAAAGGGCTCGGCACCGATGAAGACG
CCATTATTAGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGCACCATCGGCAGGGTGATTGTGG
GGATGATGACGCCCACGGTGCTGTATGACGTGCAAGAGCTGCGAAGGGCCATGAAGTTTATGTTTCATTTAAGAAGATCTTCTTTCCTGC
AAGTTTTTAACAATAGTCCTGATGAGAGTTCATATTATCGTCACCATTTTATGCGTCAAGATCTGACCCAGTCTCTAATTATGATTCAGC
CTATCCTGTATGCGTATTCTTTTAGTGGACCACCAGAGCCGGTTCTTCTTGATAGCAGTAGCATTCTTGCAGATCGTATTCTTCTCATGG
ACACATTCTTCCAGATTTTGATTTATCATGGTGAGACCATAGCACAGTGGCGGAAGTCAGGATACCAGGATATGCCTGAGTATGAAAATT
TCCGCCACCTTCTGCAAGCCCCAGTGGATGATGCACAGGAAATTCTTCACTCCAGATTTCCAATGCCAAGATACATTGACACTGAACATG
GAGGCAGCCAGGCCCGTTTCCTCCTTTCAAAAGTCAACCCTTCACAGACTCATAATAATATGTATGCCTGGGGGCAGGAGTCTGGAGCAC
CTATTCTTACAGATGATGTTAGTTTACAAGTGTTTATGGATCACTTGAAGAAACTTGCTGTGTCCAGTGCTGCTTGAAGTGCTAATAATG
TTAAAGACACTTAAGAAGATGAAATAATATTCAAATTTCATTTTTTCCTTTTTCCATTTATCTGTGGAAACCAACAGATATTGCTCTATA
TTTTTTGTATTAGTATGGTTTGAGACAACATATGGAAAATGTTCACATTTGTAGATTAAGCTGGAATTATAATGAGAGCAATAAGAACAA
ATTTATTTTGCTTACCACAGTGTTATAGCTGGTTCTAGAAATTTGAAGTCTTTATAACTTAATTATGTTTAATAAAAAATAGAGTCTGCC
TCGTACTACAGATGTAACTCATTTGTATATTGCAGACAGACCCAAAGTGGCACTGAATTTTCTTGCTCACCTTTTAAAAACTTGTTCCTT
AATTTTAGCCAGAAAGCAAAAAAACAATAGTAATGATAAATGTGAACATTTTTGCTTATTCATTGAATATTTTTCTGTAATTTTCAGCAC
TTATGTATACACTTTTTCTGTACTTACTA

>5065_5065_2_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000394295_SEC23A_chr14_39514528_ENST00000536508_length(amino acids)=272AA_BP=86
MAMATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRVIVGMMTPTVLYDVQELRRAMKFMFH
LRRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQ
DMPEYENFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKLAVSS
AA

--------------------------------------------------------------
>5065_5065_3_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000394295_SEC23A_chr14_39514528_ENST00000537403_length(transcript)=2387nt_BP=506nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGGCAACCAAAGGAG
GTACTGTCAAAGCTGCTTCAGGATTCAATGCCATGGAAGATGCCCAGACCCTGAGGAAGGCCATGAAAGGGCTCGGCACCGATGAAGACG
CCATTATTAGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGCACCATCGGCAGGGTGATTGTGG
GGATGATGACGCCCACGGTGCTGTATGACGTGCAAGAGCTGCGAAGGGCCATGAAGTTTATGTTTCATTTAAGAAGATCTTCTTTCCTGC
AAGTTTTTAACAATAGTCCTGATGAGAGTTCATATTATCGTCACCATTTTATGCGTCAAGATCTGACCCAGTCTCTAATTATGATTCAGC
CTATCCTGTATGCGTATTCTTTTAGTGGACCACCAGAGCCGGTTCTTCTTGATAGCAGTAGCATTCTTGCAGATCGTATTCTTCTCATGG
ACACATTCTTCCAGATTTTGATTTATCATGGTGAGACCATAGCACAGTGGCGGAAGTCAGGATACCAGGATATGCCTGAGTATGAAAATT
TCCGCCACCTTCTGCAAGCCCCAGTGGATGATGCACAGGAAATTCTTCACTCCAGATTTCCAATGCCAAGATACATTGACACTGAACATG
GAGGCAGCCAGGCCCGTTTCCTCCTTTCAAAAGTCAACCCTTCACAGACTCATAATAATATGTATGCCTGGGGGCAGGAGTCTGGAGCAC
CTATTCTTACAGATGATGTTAGTTTACAAGTGTTTATGGATCACTTGAAGAAACTTGCTGTGTCCAGTGCTGCTTGAAGTGCTAATAATG
TTAAAGACACTTAAGAAGATGAAATAATATTCAAATTTCATTTTTTCCTTTTTCCATTTATCTGTGGAAACCAACAGATATTGCTCTATA
TTTTTTGTATTAGTATGGTTTGAGACAACATATGGAAAATGTTCACATTTGTAGATTAAGCTGGAATTATAATGAGAGCAATAAGAACAA
ATTTATTTTGCTTACCACAGTGTTATAGCTGGTTCTAGAAATTTGAAGTCTTTATAACTTAATTATGTTTAATAAAAAATAGAGTCTGCC
TCGTACTACAGATGTAACTCATTTGTATATTGCAGACAGACCCAAAGTGGCACTGAATTTTCTTGCTCACCTTTTAAAAACTTGTTCCTT
AATTTTAGCCAGAAAGCAAAAAAACAATAGTAATGATAAATGTGAACATTTTTGCTTATTCATTGAATATTTTTCTGTAATTTTCAGCAC
TTATGTATACACTTTTTCTGTACTTACTAGGTTAAGGCAGATTTATTTTTATGATTTGTTTAGGAATTATTTGATTTTATAATGGTAATT
TTCATGATGATAATGTTTTTGGTTATTTGGAAAGATAGTTTAGAGATGAAAGGTTTTTTTGGGTAACAATCCCGCAGCTGACAAAAAATG
TGAAATTTCCACAAAATATCCAACTTATGTGACTAAACGCAGTAGTTTTTTTAAAAGGGGAGATAGAAAATAAATGGTTTTGTTGGAGTG
CATTTTAGTAAGCCTTTGCAGTAAAATGACGGTTGTAACTACTAAACCAAATTTAGTTTTCACAGCATGGTTTTGTTGTTTTCCCCTTGT
TTTTCAGAGGTAAATTTTGCATTATATCCTTCAGTATTTTAACACTATTTTGGCAGTTTACACATTACTTTTTGTTTTTCCTTCCTTTTT
GTGAAATGTATTAAGTTGTGGTTCTTATTGAAACAGTATTATATAATGTTTGCTTAATTATATCATGTGATGCTCAGTTCTATTTTGATT
TATTCATTAGTATTCACTTTTACCTTTAAAGTTTACTTGTAGCAAATATGTTTACATTGATAAAGCCAGATATGTTTTGACAATGAAATT
TACATATCAAGTACTGCAAATAAAAGGTGGTGCTATGATATATGCTTAGGAGGACAGTTTTAATGATTGTACTTGCATGAACACAATCAT
ATGATGGTAAAGCAGAAACTTAAGAAAAAATTGTTTATGTGTTATATTCAATTAGCTTAAATAAGTTGCTTTGTTATATTTTATTTGAAT
TGAACTACGCTAGGCCTAAATGCCAATAAAATATACTTTTCACTGTT

>5065_5065_3_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000394295_SEC23A_chr14_39514528_ENST00000537403_length(amino acids)=272AA_BP=86
MAMATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRVIVGMMTPTVLYDVQELRRAMKFMFH
LRRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQ
DMPEYENFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKLAVSS
AA

--------------------------------------------------------------
>5065_5065_4_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000394295_SEC23A_chr14_39514528_ENST00000545328_length(transcript)=1365nt_BP=506nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGGCAACCAAAGGAG
GTACTGTCAAAGCTGCTTCAGGATTCAATGCCATGGAAGATGCCCAGACCCTGAGGAAGGCCATGAAAGGGCTCGGCACCGATGAAGACG
CCATTATTAGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGCACCATCGGCAGGGTGATTGTGG
GGATGATGACGCCCACGGTGCTGTATGACGTGCAAGAGCTGCGAAGGGCCATGAAGTTTATGTTTCATTTAAGAAGATCTTCTTTCCTGC
AAGTTTTTAACAATAGTCCTGATGAGAGTTCATATTATCGTCACCATTTTATGCGTCAAGATCTGACCCAGTCTCTAATTATGATTCAGC
CTATCCTGTATGCGTATTCTTTTAGTGGACCACCAGAGCCGGTTCTTCTTGATAGCAGTAGCATTCTTGCAGATCGTATTCTTCTCATGG
ACACATTCTTCCAGATTTTGATTTATCATGGTGAGACCATAGCACAGTGGCGGAAGTCAGGATACCAGGATATGCCTGAGTATGAAAATT
TCCGCCACCTTCTGCAAGCCCCAGTGGATGATGCACAGGAAATTCTTCACTCCAGATTTCCAATGCCAAGATACATTGACACTGAACATG
GAGGCAGCCAGGCCCGTTTCCTCCTTTCAAAAGTCAACCCTTCACAGACTCATAATAATATGTATGCCTGGGGGCAGGAGTCTGGAGCAC
CTATTCTTACAGATGATGTTAGTTTACAAGTGTTTATGGATCACTTGAAGAAACTTGCTGTGTCCAGTGCTGCTTGAAGTGCTAATAATG
TTAAAGACACTTAAGAAGATGAAATAATATTCAAATTTCATTTTTTCCTTTTTCCATTTATCTGTGGAAACCAACAGATATTGCTCTATA
TTTTTTGTATTAGTATGGTTTGAGACAACATATGGAAAATGTTCACATTTGTAGATTAAGCTGGAATTATAATGAGAGCAATAAGAACAA
ATTTATTTTGCTTACCACAGTGTTATAGCTGGTTCTAGAAATTTGAAGTCTTTATAACTTAATTATGTTTAATAAAAAATAGAGTCTGCC
TCGTACTACAGATGT

>5065_5065_4_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000394295_SEC23A_chr14_39514528_ENST00000545328_length(amino acids)=272AA_BP=86
MAMATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRVIVGMMTPTVLYDVQELRRAMKFMFH
LRRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQ
DMPEYENFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKLAVSS
AA

--------------------------------------------------------------
>5065_5065_5_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000409920_SEC23A_chr14_39514528_ENST00000307712_length(transcript)=2368nt_BP=488nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGGCAACCAAAGGAG
GTACTGTCAAAGCTGCTTCAGGATTCAATGCCATGGAAGATGCCCAGACCCTGAGGAAGGCCATGAAAGGGCTCGGCACCGATGAAGACG
CCATTATTAGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGCACCATCGGCAGGGACTTGATAG
ACGACCTGAAGTCAGAACTGAGTGGCAACTTCGAGCAGTTTATGTTTCATTTAAGAAGATCTTCTTTCCTGCAAGTTTTTAACAATAGTC
CTGATGAGAGTTCATATTATCGTCACCATTTTATGCGTCAAGATCTGACCCAGTCTCTAATTATGATTCAGCCTATCCTGTATGCGTATT
CTTTTAGTGGACCACCAGAGCCGGTTCTTCTTGATAGCAGTAGCATTCTTGCAGATCGTATTCTTCTCATGGACACATTCTTCCAGATTT
TGATTTATCATGGTGAGACCATAGCACAGTGGCGGAAGTCAGGATACCAGGATATGCCTGAGTATGAAAATTTCCGCCACCTTCTGCAAG
CCCCAGTGGATGATGCACAGGAAATTCTTCACTCCAGATTTCCAATGCCAAGATACATTGACACTGAACATGGAGGCAGCCAGGCCCGTT
TCCTCCTTTCAAAAGTCAACCCTTCACAGACTCATAATAATATGTATGCCTGGGGGCAGGAGTCTGGAGCACCTATTCTTACAGATGATG
TTAGTTTACAAGTGTTTATGGATCACTTGAAGAAACTTGCTGTGTCCAGTGCTGCTTGAAGTGCTAATAATGTTAAAGACACTTAAGAAG
ATGAAATAATATTCAAATTTCATTTTTTCCTTTTTCCATTTATCTGTGGAAACCAACAGATATTGCTCTATATTTTTTGTATTAGTATGG
TTTGAGACAACATATGGAAAATGTTCACATTTGTAGATTAAGCTGGAATTATAATGAGAGCAATAAGAACAAATTTATTTTGCTTACCAC
AGTGTTATAGCTGGTTCTAGAAATTTGAAGTCTTTATAACTTAATTATGTTTAATAAAAAATAGAGTCTGCCTCGTACTACAGATGTAAC
TCATTTGTATATTGCAGACAGACCCAAAGTGGCACTGAATTTTCTTGCTCACCTTTTAAAAACTTGTTCCTTAATTTTAGCCAGAAAGCA
AAAAAACAATAGTAATGATAAATGTGAACATTTTTGCTTATTCATTGAATATTTTTCTGTAATTTTCAGCACTTATGTATACACTTTTTC
TGTACTTACTAGGTTAAGGCAGATTTATTTTTATGATTTGTTTAGGAATTATTTGATTTTATAATGGTAATTTTCATGATGATAATGTTT
TTGGTTATTTGGAAAGATAGTTTAGAGATGAAAGGTTTTTTTGGGTAACAATCCCGCAGCTGACAAAAAATGTGAAATTTCCACAAAATA
TCCAACTTATGTGACTAAACGCAGTAGTTTTTTTAAAAGGGGAGATAGAAAATAAATGGTTTTGTTGGAGTGCATTTTAGTAAGCCTTTG
CAGTAAAATGACGGTTGTAACTACTAAACCAAATTTAGTTTTCACAGCATGGTTTTGTTGTTTTCCCCTTGTTTTTCAGAGGTAAATTTT
GCATTATATCCTTCAGTATTTTAACACTATTTTGGCAGTTTACACATTACTTTTTGTTTTTCCTTCCTTTTTGTGAAATGTATTAAGTTG
TGGTTCTTATTGAAACAGTATTATATAATGTTTGCTTAATTATATCATGTGATGCTCAGTTCTATTTTGATTTATTCATTAGTATTCACT
TTTACCTTTAAAGTTTACTTGTAGCAAATATGTTTACATTGATAAAGCCAGATATGTTTTGACAATGAAATTTACATATCAAGTACTGCA
AATAAAAGGTGGTGCTATGATATATGCTTAGGAGGACAGTTTTAATGATTGTACTTGCATGAACACAATCATATGATGGTAAAGCAGAAA
CTTAAGAAAAAATTGTTTATGTGTTATATTCAATTAGCTTAAATAAGTTGCTTTGTTATATTTTATTTGAATTGAACTACGCTAGGCCTA
AATGCCAATAAAATATACTTTTCACTGT

>5065_5065_5_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000409920_SEC23A_chr14_39514528_ENST00000307712_length(amino acids)=266AA_BP=79
MAMATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQFMFHLRRSSF
LQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYE
NFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKLAVSSAA

--------------------------------------------------------------
>5065_5065_6_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000409920_SEC23A_chr14_39514528_ENST00000536508_length(transcript)=1541nt_BP=488nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGGCAACCAAAGGAG
GTACTGTCAAAGCTGCTTCAGGATTCAATGCCATGGAAGATGCCCAGACCCTGAGGAAGGCCATGAAAGGGCTCGGCACCGATGAAGACG
CCATTATTAGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGCACCATCGGCAGGGACTTGATAG
ACGACCTGAAGTCAGAACTGAGTGGCAACTTCGAGCAGTTTATGTTTCATTTAAGAAGATCTTCTTTCCTGCAAGTTTTTAACAATAGTC
CTGATGAGAGTTCATATTATCGTCACCATTTTATGCGTCAAGATCTGACCCAGTCTCTAATTATGATTCAGCCTATCCTGTATGCGTATT
CTTTTAGTGGACCACCAGAGCCGGTTCTTCTTGATAGCAGTAGCATTCTTGCAGATCGTATTCTTCTCATGGACACATTCTTCCAGATTT
TGATTTATCATGGTGAGACCATAGCACAGTGGCGGAAGTCAGGATACCAGGATATGCCTGAGTATGAAAATTTCCGCCACCTTCTGCAAG
CCCCAGTGGATGATGCACAGGAAATTCTTCACTCCAGATTTCCAATGCCAAGATACATTGACACTGAACATGGAGGCAGCCAGGCCCGTT
TCCTCCTTTCAAAAGTCAACCCTTCACAGACTCATAATAATATGTATGCCTGGGGGCAGGAGTCTGGAGCACCTATTCTTACAGATGATG
TTAGTTTACAAGTGTTTATGGATCACTTGAAGAAACTTGCTGTGTCCAGTGCTGCTTGAAGTGCTAATAATGTTAAAGACACTTAAGAAG
ATGAAATAATATTCAAATTTCATTTTTTCCTTTTTCCATTTATCTGTGGAAACCAACAGATATTGCTCTATATTTTTTGTATTAGTATGG
TTTGAGACAACATATGGAAAATGTTCACATTTGTAGATTAAGCTGGAATTATAATGAGAGCAATAAGAACAAATTTATTTTGCTTACCAC
AGTGTTATAGCTGGTTCTAGAAATTTGAAGTCTTTATAACTTAATTATGTTTAATAAAAAATAGAGTCTGCCTCGTACTACAGATGTAAC
TCATTTGTATATTGCAGACAGACCCAAAGTGGCACTGAATTTTCTTGCTCACCTTTTAAAAACTTGTTCCTTAATTTTAGCCAGAAAGCA
AAAAAACAATAGTAATGATAAATGTGAACATTTTTGCTTATTCATTGAATATTTTTCTGTAATTTTCAGCACTTATGTATACACTTTTTC
TGTACTTACTA

>5065_5065_6_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000409920_SEC23A_chr14_39514528_ENST00000536508_length(amino acids)=266AA_BP=79
MAMATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQFMFHLRRSSF
LQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYE
NFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKLAVSSAA

--------------------------------------------------------------
>5065_5065_7_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000409920_SEC23A_chr14_39514528_ENST00000537403_length(transcript)=2369nt_BP=488nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGGCAACCAAAGGAG
GTACTGTCAAAGCTGCTTCAGGATTCAATGCCATGGAAGATGCCCAGACCCTGAGGAAGGCCATGAAAGGGCTCGGCACCGATGAAGACG
CCATTATTAGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGCACCATCGGCAGGGACTTGATAG
ACGACCTGAAGTCAGAACTGAGTGGCAACTTCGAGCAGTTTATGTTTCATTTAAGAAGATCTTCTTTCCTGCAAGTTTTTAACAATAGTC
CTGATGAGAGTTCATATTATCGTCACCATTTTATGCGTCAAGATCTGACCCAGTCTCTAATTATGATTCAGCCTATCCTGTATGCGTATT
CTTTTAGTGGACCACCAGAGCCGGTTCTTCTTGATAGCAGTAGCATTCTTGCAGATCGTATTCTTCTCATGGACACATTCTTCCAGATTT
TGATTTATCATGGTGAGACCATAGCACAGTGGCGGAAGTCAGGATACCAGGATATGCCTGAGTATGAAAATTTCCGCCACCTTCTGCAAG
CCCCAGTGGATGATGCACAGGAAATTCTTCACTCCAGATTTCCAATGCCAAGATACATTGACACTGAACATGGAGGCAGCCAGGCCCGTT
TCCTCCTTTCAAAAGTCAACCCTTCACAGACTCATAATAATATGTATGCCTGGGGGCAGGAGTCTGGAGCACCTATTCTTACAGATGATG
TTAGTTTACAAGTGTTTATGGATCACTTGAAGAAACTTGCTGTGTCCAGTGCTGCTTGAAGTGCTAATAATGTTAAAGACACTTAAGAAG
ATGAAATAATATTCAAATTTCATTTTTTCCTTTTTCCATTTATCTGTGGAAACCAACAGATATTGCTCTATATTTTTTGTATTAGTATGG
TTTGAGACAACATATGGAAAATGTTCACATTTGTAGATTAAGCTGGAATTATAATGAGAGCAATAAGAACAAATTTATTTTGCTTACCAC
AGTGTTATAGCTGGTTCTAGAAATTTGAAGTCTTTATAACTTAATTATGTTTAATAAAAAATAGAGTCTGCCTCGTACTACAGATGTAAC
TCATTTGTATATTGCAGACAGACCCAAAGTGGCACTGAATTTTCTTGCTCACCTTTTAAAAACTTGTTCCTTAATTTTAGCCAGAAAGCA
AAAAAACAATAGTAATGATAAATGTGAACATTTTTGCTTATTCATTGAATATTTTTCTGTAATTTTCAGCACTTATGTATACACTTTTTC
TGTACTTACTAGGTTAAGGCAGATTTATTTTTATGATTTGTTTAGGAATTATTTGATTTTATAATGGTAATTTTCATGATGATAATGTTT
TTGGTTATTTGGAAAGATAGTTTAGAGATGAAAGGTTTTTTTGGGTAACAATCCCGCAGCTGACAAAAAATGTGAAATTTCCACAAAATA
TCCAACTTATGTGACTAAACGCAGTAGTTTTTTTAAAAGGGGAGATAGAAAATAAATGGTTTTGTTGGAGTGCATTTTAGTAAGCCTTTG
CAGTAAAATGACGGTTGTAACTACTAAACCAAATTTAGTTTTCACAGCATGGTTTTGTTGTTTTCCCCTTGTTTTTCAGAGGTAAATTTT
GCATTATATCCTTCAGTATTTTAACACTATTTTGGCAGTTTACACATTACTTTTTGTTTTTCCTTCCTTTTTGTGAAATGTATTAAGTTG
TGGTTCTTATTGAAACAGTATTATATAATGTTTGCTTAATTATATCATGTGATGCTCAGTTCTATTTTGATTTATTCATTAGTATTCACT
TTTACCTTTAAAGTTTACTTGTAGCAAATATGTTTACATTGATAAAGCCAGATATGTTTTGACAATGAAATTTACATATCAAGTACTGCA
AATAAAAGGTGGTGCTATGATATATGCTTAGGAGGACAGTTTTAATGATTGTACTTGCATGAACACAATCATATGATGGTAAAGCAGAAA
CTTAAGAAAAAATTGTTTATGTGTTATATTCAATTAGCTTAAATAAGTTGCTTTGTTATATTTTATTTGAATTGAACTACGCTAGGCCTA
AATGCCAATAAAATATACTTTTCACTGTT

>5065_5065_7_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000409920_SEC23A_chr14_39514528_ENST00000537403_length(amino acids)=266AA_BP=79
MAMATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQFMFHLRRSSF
LQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYE
NFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKLAVSSAA

--------------------------------------------------------------
>5065_5065_8_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000409920_SEC23A_chr14_39514528_ENST00000545328_length(transcript)=1347nt_BP=488nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGGCAACCAAAGGAG
GTACTGTCAAAGCTGCTTCAGGATTCAATGCCATGGAAGATGCCCAGACCCTGAGGAAGGCCATGAAAGGGCTCGGCACCGATGAAGACG
CCATTATTAGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGCACCATCGGCAGGGACTTGATAG
ACGACCTGAAGTCAGAACTGAGTGGCAACTTCGAGCAGTTTATGTTTCATTTAAGAAGATCTTCTTTCCTGCAAGTTTTTAACAATAGTC
CTGATGAGAGTTCATATTATCGTCACCATTTTATGCGTCAAGATCTGACCCAGTCTCTAATTATGATTCAGCCTATCCTGTATGCGTATT
CTTTTAGTGGACCACCAGAGCCGGTTCTTCTTGATAGCAGTAGCATTCTTGCAGATCGTATTCTTCTCATGGACACATTCTTCCAGATTT
TGATTTATCATGGTGAGACCATAGCACAGTGGCGGAAGTCAGGATACCAGGATATGCCTGAGTATGAAAATTTCCGCCACCTTCTGCAAG
CCCCAGTGGATGATGCACAGGAAATTCTTCACTCCAGATTTCCAATGCCAAGATACATTGACACTGAACATGGAGGCAGCCAGGCCCGTT
TCCTCCTTTCAAAAGTCAACCCTTCACAGACTCATAATAATATGTATGCCTGGGGGCAGGAGTCTGGAGCACCTATTCTTACAGATGATG
TTAGTTTACAAGTGTTTATGGATCACTTGAAGAAACTTGCTGTGTCCAGTGCTGCTTGAAGTGCTAATAATGTTAAAGACACTTAAGAAG
ATGAAATAATATTCAAATTTCATTTTTTCCTTTTTCCATTTATCTGTGGAAACCAACAGATATTGCTCTATATTTTTTGTATTAGTATGG
TTTGAGACAACATATGGAAAATGTTCACATTTGTAGATTAAGCTGGAATTATAATGAGAGCAATAAGAACAAATTTATTTTGCTTACCAC
AGTGTTATAGCTGGTTCTAGAAATTTGAAGTCTTTATAACTTAATTATGTTTAATAAAAAATAGAGTCTGCCTCGTACTACAGATGT

>5065_5065_8_ANXA4-SEC23A_ANXA4_chr2_70033564_ENST00000409920_SEC23A_chr14_39514528_ENST00000545328_length(amino acids)=266AA_BP=79
MAMATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQFMFHLRRSSF
LQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYE
NFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKLAVSSAA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANXA4-SEC23A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANXA4-SEC23A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANXA4-SEC23A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANXA4C0007097Carcinoma1CTD_human
HgeneANXA4C0007134Renal Cell Carcinoma1CTD_human
HgeneANXA4C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneANXA4C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneANXA4C0023903Liver neoplasms1CTD_human
HgeneANXA4C0024667Animal Mammary Neoplasms1CTD_human
HgeneANXA4C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneANXA4C0026998Acute Myeloid Leukemia, M11CTD_human
HgeneANXA4C0027627Neoplasm Metastasis1CTD_human
HgeneANXA4C0032927Precancerous Conditions1CTD_human
HgeneANXA4C0033578Prostatic Neoplasms1CTD_human
HgeneANXA4C0205696Anaplastic carcinoma1CTD_human
HgeneANXA4C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneANXA4C0205698Undifferentiated carcinoma1CTD_human
HgeneANXA4C0205699Carcinomatosis1CTD_human
HgeneANXA4C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneANXA4C0282313Condition, Preneoplastic1CTD_human
HgeneANXA4C0345904Malignant neoplasm of liver1CTD_human
HgeneANXA4C0376358Malignant neoplasm of prostate1CTD_human
HgeneANXA4C1257925Mammary Carcinoma, Animal1CTD_human
HgeneANXA4C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneANXA4C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneANXA4C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneANXA4C1306837Papillary Renal Cell Carcinoma1CTD_human
HgeneANXA4C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneANXA4C2239176Liver carcinoma1CTD_human
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0086743Osteoarthrosis Deformans1CTD_human
TgeneC1843042Craniolenticulosutural Dysplasia1CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT