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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HGF-C5orf17 (FusionGDB2 ID:HG3082TG439936)

Fusion Gene Summary for HGF-C5orf17

check button Fusion gene summary
Fusion gene informationFusion gene name: HGF-C5orf17
Fusion gene ID: hg3082tg439936
HgeneTgene
Gene symbol

HGF

C5orf17

Gene ID

3082

439936

Gene namehepatocyte growth factorchromosome 5 putative open reading frame 17
SynonymsDFNB39|F-TCF|HGFB|HPTA|SF-
Cytomap('HGF')('C5orf17')

7q21.11

5p14.2

Type of geneprotein-codingncRNA
Descriptionhepatocyte growth factorfibroblast-derived tumor cytotoxic factorhepatocyte growth factor (hepapoietin A; scatter factor)hepatopoietin-Alung fibroblast-derived mitogen-
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000222390, ENST00000354224, 
ENST00000423064, ENST00000444829, 
ENST00000453018, ENST00000453411, 
ENST00000457544, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 2=32
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HGF [Title/Abstract] AND C5orf17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHGF(81380216)-C5orf17(24091902), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHGF

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

20655899

HgeneHGF

GO:0030335

positive regulation of cell migration

21245381

HgeneHGF

GO:0035729

cellular response to hepatocyte growth factor stimulus

21245381

HgeneHGF

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

20655899

HgeneHGF

GO:0048012

hepatocyte growth factor receptor signaling pathway

21245381

HgeneHGF

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

21245381

HgeneHGF

GO:0060326

cell chemotaxis

21245381

HgeneHGF

GO:0060665

regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

14517989

HgeneHGF

GO:0090201

negative regulation of release of cytochrome c from mitochondria

20655899

HgeneHGF

GO:1901299

negative regulation of hydrogen peroxide-mediated programmed cell death

20655899

HgeneHGF

GO:2000573

positive regulation of DNA biosynthetic process

2531289



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for HGF-C5orf17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HGF-C5orf17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for HGF-C5orf17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:81380216/:24091902)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HGF-C5orf17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HGF-C5orf17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HGF-C5orf17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HGF-C5orf17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHGFC0023893Liver Cirrhosis, Experimental7CTD_human
HgeneHGFC0027626Neoplasm Invasiveness2CTD_human
HgeneHGFC0033141Cardiomyopathies, Primary2CTD_human
HgeneHGFC0036529Myocardial Diseases, Secondary2CTD_human
HgeneHGFC0878544Cardiomyopathies2CTD_human
HgeneHGFC2239176Liver carcinoma2CTD_human
HgeneHGFC3711374Nonsyndromic Deafness2CLINGEN
HgeneHGFC0004114Astrocytoma1CTD_human
HgeneHGFC0004763Barrett Esophagus1CTD_human
HgeneHGFC0007137Squamous cell carcinoma1CTD_human
HgeneHGFC0011882Diabetic Neuropathies1CTD_human
HgeneHGFC0019189Hepatitis, Chronic1CTD_human
HgeneHGFC0019207Hepatoma, Morris1CTD_human
HgeneHGFC0019208Hepatoma, Novikoff1CTD_human
HgeneHGFC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneHGFC0023890Liver Cirrhosis1CTD_human
HgeneHGFC0023903Liver neoplasms1CTD_human
HgeneHGFC0023904Liver Neoplasms, Experimental1CTD_human
HgeneHGFC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneHGFC0027627Neoplasm Metastasis1CTD_human
HgeneHGFC0027659Neoplasms, Experimental1CTD_human
HgeneHGFC0027819Neuroblastoma1CTD_human
HgeneHGFC0030193Pain1CTD_human
HgeneHGFC0030305Pancreatitis1CTD_human
HgeneHGFC0030567Parkinson Disease1CTD_human
HgeneHGFC0034069Pulmonary Fibrosis1CTD_human
HgeneHGFC0035126Reperfusion Injury1CTD_human
HgeneHGFC0040053Thrombosis1CTD_human
HgeneHGFC0042373Vascular Diseases1CTD_human
HgeneHGFC0086404Experimental Hepatoma1CTD_human
HgeneHGFC0087086Thrombus1CTD_human
HgeneHGFC0149519Chronic Persistent Hepatitis1CTD_human
HgeneHGFC0151744Myocardial Ischemia1CTD_human
HgeneHGFC0162557Liver Failure, Acute1CTD_human
HgeneHGFC0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneHGFC0234230Pain, Burning1CTD_human
HgeneHGFC0234238Ache1CTD_human
HgeneHGFC0234254Radiating pain1CTD_human
HgeneHGFC0239946Fibrosis, Liver1CTD_human
HgeneHGFC0271673Symmetric Diabetic Proximal Motor Neuropathy1CTD_human
HgeneHGFC0271674Asymmetric Diabetic Proximal Motor Neuropathy1CTD_human
HgeneHGFC0271678Diabetic Mononeuropathy1CTD_human
HgeneHGFC0271680Diabetic Polyneuropathies1CTD_human
HgeneHGFC0271685Diabetic Amyotrophy1CTD_human
HgeneHGFC0271686Diabetic Autonomic Neuropathy1CTD_human
HgeneHGFC0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneHGFC0280785Diffuse Astrocytoma1CTD_human
HgeneHGFC0334579Anaplastic astrocytoma1CTD_human
HgeneHGFC0334580Protoplasmic astrocytoma1CTD_human
HgeneHGFC0334581Gemistocytic astrocytoma1CTD_human
HgeneHGFC0334582Fibrillary Astrocytoma1CTD_human
HgeneHGFC0334583Pilocytic Astrocytoma1CTD_human
HgeneHGFC0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneHGFC0345904Malignant neoplasm of liver1CTD_human
HgeneHGFC0345967Malignant mesothelioma1CTD_human
HgeneHGFC0393835Diabetic Asymmetric Polyneuropathy1CTD_human
HgeneHGFC0458257Pain, Splitting1CTD_human
HgeneHGFC0458259Pain, Crushing1CTD_human
HgeneHGFC0520463Chronic active hepatitis1CTD_human
HgeneHGFC0524611Cryptogenic Chronic Hepatitis1CTD_human
HgeneHGFC0547065Mixed oligoastrocytoma1CTD_human
HgeneHGFC0750935Cerebral Astrocytoma1CTD_human
HgeneHGFC0750936Intracranial Astrocytoma1CTD_human
HgeneHGFC0751074Diabetic Neuralgia1CTD_human
HgeneHGFC0751407Pain, Migratory1CTD_human
HgeneHGFC0751408Suffering, Physical1CTD_human
HgeneHGFC0949804Polyomavirus Infections1CTD_human
HgeneHGFC1258085Barrett Epithelium1CTD_human
HgeneHGFC1704230Grade I Astrocytoma1CTD_human
HgeneHGFC1842342DEAFNESS, AUTOSOMAL RECESSIVE 39 (disorder)1CTD_human;GENOMICS_ENGLAND
HgeneHGFC1876165Copper-Overload Cirrhosis1CTD_human
HgeneHGFC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneHGFC4721507Alveolitis, Fibrosing1CTD_human