Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:HK1-FUS (FusionGDB2 ID:HG3098TG2521)

Fusion Gene Summary for HK1-FUS

check button Fusion gene summary
Fusion gene informationFusion gene name: HK1-FUS
Fusion gene ID: hg3098tg2521
HgeneTgene
Gene symbol

HK1

FUS

Gene ID

3098

2521

Gene namehexokinase 1FUS RNA binding protein
SynonymsHK|HK1-ta|HK1-tb|HK1-tc|HKD|HKI|HMSNR|HXK1|NEDVIBA|RP79|hexokinaseALS6|ETM4|FUS1|HNRNPP2|POMP75|TLS
Cytomap('HK1')('FUS')

10q22.1

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionhexokinase-1brain form hexokinaseglycolytic enzymehexokinase IRhexokinase type Ihexokinase-ARNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma protein
Modification date2020032820200329
UniProtAcc

P19367

P35637

Ensembl transtripts involved in fusion geneENST00000494253, ENST00000298649, 
ENST00000359426, ENST00000360289, 
ENST00000404387, ENST00000448642, 
Fusion gene scores* DoF score15 X 16 X 5=120020 X 13 X 10=2600
# samples 2122
** MAII scorelog2(21/1200*10)=-2.51457317282976
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2600*10)=-3.56293619439116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HK1 [Title/Abstract] AND FUS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHK1(71103745)-FUS(31199646), # samples:1
Anticipated loss of major functional domain due to fusion event.HK1-FUS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HK1-FUS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HK1-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HK1-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFUS

GO:0006355

regulation of transcription, DNA-templated

26124092

TgeneFUS

GO:0006357

regulation of transcription by RNA polymerase II

25453086

TgeneFUS

GO:0008380

RNA splicing

26124092

TgeneFUS

GO:0043484

regulation of RNA splicing

25453086|27731383

TgeneFUS

GO:0048255

mRNA stabilization

27378374

TgeneFUS

GO:0051260

protein homooligomerization

25453086

TgeneFUS

GO:1905168

positive regulation of double-strand break repair via homologous recombination

10567410


check buttonFusion gene breakpoints across HK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FUS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-8211-01AHK1chr10

71103745

+FUSchr16

31199646

+


Top

Fusion Gene ORF analysis for HK1-FUS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000494253ENST00000254108HK1chr10

71103745

+FUSchr16

31199646

+
3UTR-3CDSENST00000494253ENST00000380244HK1chr10

71103745

+FUSchr16

31199646

+
3UTR-3CDSENST00000494253ENST00000568685HK1chr10

71103745

+FUSchr16

31199646

+
3UTR-3UTRENST00000494253ENST00000474990HK1chr10

71103745

+FUSchr16

31199646

+
5CDS-3UTRENST00000298649ENST00000474990HK1chr10

71103745

+FUSchr16

31199646

+
5CDS-3UTRENST00000359426ENST00000474990HK1chr10

71103745

+FUSchr16

31199646

+
5CDS-3UTRENST00000360289ENST00000474990HK1chr10

71103745

+FUSchr16

31199646

+
5CDS-3UTRENST00000404387ENST00000474990HK1chr10

71103745

+FUSchr16

31199646

+
5CDS-3UTRENST00000448642ENST00000474990HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000298649ENST00000254108HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000298649ENST00000380244HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000298649ENST00000568685HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000359426ENST00000254108HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000359426ENST00000380244HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000359426ENST00000568685HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000360289ENST00000254108HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000360289ENST00000380244HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000360289ENST00000568685HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000404387ENST00000254108HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000404387ENST00000380244HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000404387ENST00000568685HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000448642ENST00000254108HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000448642ENST00000380244HK1chr10

71103745

+FUSchr16

31199646

+
In-frameENST00000448642ENST00000568685HK1chr10

71103745

+FUSchr16

31199646

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360289HK1chr1071103745+ENST00000254108FUSchr1631199646+18396894811470329
ENST00000360289HK1chr1071103745+ENST00000380244FUSchr1631199646+16356894811470329
ENST00000360289HK1chr1071103745+ENST00000568685FUSchr1631199646+16116894811473330
ENST00000448642HK1chr1071103745+ENST00000254108FUSchr1631199646+18707203891501370
ENST00000448642HK1chr1071103745+ENST00000380244FUSchr1631199646+16667203891501370
ENST00000448642HK1chr1071103745+ENST00000568685FUSchr1631199646+16427203891504371
ENST00000404387HK1chr1071103745+ENST00000254108FUSchr1631199646+138823801019339
ENST00000404387HK1chr1071103745+ENST00000380244FUSchr1631199646+118423801019339
ENST00000404387HK1chr1071103745+ENST00000568685FUSchr1631199646+116023801022340
ENST00000298649HK1chr1071103745+ENST00000254108FUSchr1631199646+14743241011105334
ENST00000298649HK1chr1071103745+ENST00000380244FUSchr1631199646+12703241011105334
ENST00000298649HK1chr1071103745+ENST00000568685FUSchr1631199646+12463241011108335
ENST00000359426HK1chr1071103745+ENST00000254108FUSchr1631199646+1480330501111353
ENST00000359426HK1chr1071103745+ENST00000380244FUSchr1631199646+1276330501111353
ENST00000359426HK1chr1071103745+ENST00000568685FUSchr1631199646+1252330501114354

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360289ENST00000254108HK1chr1071103745+FUSchr1631199646+0.0021162050.99788374
ENST00000360289ENST00000380244HK1chr1071103745+FUSchr1631199646+0.0023915150.9976084
ENST00000360289ENST00000568685HK1chr1071103745+FUSchr1631199646+0.0026537930.99734616
ENST00000448642ENST00000254108HK1chr1071103745+FUSchr1631199646+0.0055281010.9944719
ENST00000448642ENST00000380244HK1chr1071103745+FUSchr1631199646+0.0065354440.9934645
ENST00000448642ENST00000568685HK1chr1071103745+FUSchr1631199646+0.0090644260.9909356
ENST00000404387ENST00000254108HK1chr1071103745+FUSchr1631199646+0.0005558990.99944407
ENST00000404387ENST00000380244HK1chr1071103745+FUSchr1631199646+0.0005899360.99941003
ENST00000404387ENST00000568685HK1chr1071103745+FUSchr1631199646+0.0011564580.99884355
ENST00000298649ENST00000254108HK1chr1071103745+FUSchr1631199646+0.0013623780.9986376
ENST00000298649ENST00000380244HK1chr1071103745+FUSchr1631199646+0.0013932830.99860674
ENST00000298649ENST00000568685HK1chr1071103745+FUSchr1631199646+0.0022286910.9977714
ENST00000359426ENST00000254108HK1chr1071103745+FUSchr1631199646+0.0014468160.9985532
ENST00000359426ENST00000380244HK1chr1071103745+FUSchr1631199646+0.0013924280.9986076
ENST00000359426ENST00000568685HK1chr1071103745+FUSchr1631199646+0.0019937210.9980063

Top

Fusion Genomic Features for HK1-FUS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HK1chr1071103745+FUSchr1631199645+2.29E-070.99999976
HK1chr1071103745+FUSchr1631199645+2.29E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for HK1-FUS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:71103745/chr16:31199646)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HK1

P19367

FUS

P35637

FUNCTION: Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000269|PubMed:1637300, ECO:0000269|PubMed:25316723, ECO:0000269|PubMed:27374331}.FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+2181_1074917.0RegionMitochondrial-binding peptide (MBP)
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+2181_1075918.0RegionMitochondrial-binding peptide (MBP)
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+6221_1063906.0RegionMitochondrial-binding peptide (MBP)
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+3191_1079922.0RegionMitochondrial-binding peptide (MBP)
TgeneFUSchr10:71103745chr16:31199646ENST00000254108615371_526266527.0Compositional biasNote=Arg/Gly-rich
TgeneFUSchr10:71103745chr16:31199646ENST00000380244615371_526265526.0Compositional biasNote=Arg/Gly-rich
TgeneFUSchr10:71103745chr16:31199646ENST00000254108615285_371266527.0DomainRRM
TgeneFUSchr10:71103745chr16:31199646ENST00000380244615285_371265526.0DomainRRM
TgeneFUSchr10:71103745chr16:31199646ENST00000254108615422_453266527.0Zinc fingerRanBP2-type
TgeneFUSchr10:71103745chr16:31199646ENST00000380244615422_453265526.0Zinc fingerRanBP2-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+21816_45874917.0DomainHexokinase 1
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218464_90674917.0DomainHexokinase 2
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+21816_45875918.0DomainHexokinase 1
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218464_90675918.0DomainHexokinase 2
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+62216_45863906.0DomainHexokinase 1
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622464_90663906.0DomainHexokinase 2
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+31916_45879922.0DomainHexokinase 1
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319464_90679922.0DomainHexokinase 2
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218425_42674917.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218532_53774917.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218747_74874917.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218784_78874917.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+21884_8974917.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218425_42675918.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218532_53775918.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218747_74875918.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218784_78875918.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+21884_8975918.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622425_42663906.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622532_53763906.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622747_74863906.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622784_78863906.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+62284_8963906.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319425_42679922.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319532_53779922.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319747_74879922.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319784_78879922.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+31984_8979922.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218172_17374917.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218208_20974917.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218208_44774917.0RegionHexokinase large subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218291_29474917.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218413_41574917.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218521_65574917.0RegionHexokinase small subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218532_53674917.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218603_60474917.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218620_62174917.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218656_65774917.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218656_89574917.0RegionHexokinase large subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218682_68374917.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+21873_20774917.0RegionHexokinase small subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+21884_9174917.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218861_86374917.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218172_17375918.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218208_20975918.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218208_44775918.0RegionHexokinase large subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218291_29475918.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218413_41575918.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218521_65575918.0RegionHexokinase small subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218532_53675918.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218603_60475918.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218620_62175918.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218656_65775918.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218656_89575918.0RegionHexokinase large subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218682_68375918.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+21873_20775918.0RegionHexokinase small subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+21884_9175918.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218861_86375918.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622172_17363906.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622208_20963906.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622208_44763906.0RegionHexokinase large subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622291_29463906.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622413_41563906.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622521_65563906.0RegionHexokinase small subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622532_53663906.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622603_60463906.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622620_62163906.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622656_65763906.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622656_89563906.0RegionHexokinase large subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622682_68363906.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+62273_20763906.0RegionHexokinase small subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+62284_9163906.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622861_86363906.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319172_17379922.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319208_20979922.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319208_44779922.0RegionHexokinase large subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319291_29479922.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319413_41579922.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319521_65579922.0RegionHexokinase small subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319532_53679922.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319603_60479922.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319620_62179922.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319656_65779922.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319656_89579922.0RegionHexokinase large subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319682_68379922.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+31973_20779922.0RegionHexokinase small subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+31984_9179922.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319861_86379922.0RegionGlucose-6-phosphate 2 binding
TgeneFUSchr10:71103745chr16:31199646ENST00000254108615166_267266527.0Compositional biasNote=Gly-rich
TgeneFUSchr10:71103745chr16:31199646ENST000002541086151_165266527.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
TgeneFUSchr10:71103745chr16:31199646ENST00000380244615166_267265526.0Compositional biasNote=Gly-rich
TgeneFUSchr10:71103745chr16:31199646ENST000003802446151_165265526.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich


Top

Fusion Gene Sequence for HK1-FUS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36575_36575_1_HK1-FUS_HK1_chr10_71103745_ENST00000298649_FUS_chr16_31199646_ENST00000254108_length(transcript)=1474nt_BP=324nt
CCTGGCTCAAAACTCTACCACAACCTGACACTGGGCAAGATGGCCCACCTGTGGCATCCCAGGTTCCTGCCCTGTAAAGAGGAGTCTGGG
TGTATATCCAGATGGACTGTGAGCACAGCCTGAGTTTGCCCTGTCGAGGTGCTGAGGCCTGGGAGATTGGGATTGACAAGTATCTCTATG
CCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAATCCAA
CAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGGCCCTCGGGACCAAGGATCACGTCATGACTCCGAAC
AGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTACAATTGAGTCTGTGGCTGATTACTTCAAGCAGATTG
GTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAGACAGGGAAACTGGCAAGCTGAAGGGAGAGGCAACGG
TCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATGGTAAAGAATTCTCCGGAAATCCTATCAAGGTCTCATTTG
CTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAGGGCGAGGAGGACCCATGGGCCGTGGAGGCTATGGAG
GTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTGGCGGTGGAGGACAGCAGCGAGCTGGTGACTGGAAGTGTC
CTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGTGTAAGGCCCCTAAACCAGATGGCCCAGGAGGGGGAC
CAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCAGAGGAGGCTATGATCGAGGCGGCTACCGGGGCCGCGGCG
GGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCTTTGGCCCTGGCAAGATGGATTCCAGGGGTGAGCACAGAC
AGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGAACAGCTTTTTGTCCTGTACCCAGTGTTACCCTCGTTATT
TTGTAACCTTCCAATTCCTGATCACCCAAGGGTTTTTTTGTGTCGGACTATGTAATTGTAACTATACCTCTGGTTCCCATTAAAAGTGAC
CATTTTAGTTAAATTTTGTTCCTCTTCCCCCTTTTCACTTTCCTGGAAGATCGATGTCCCGATCAGGAAGGTAGAGAGTTTTCCTGTTCA
GATTACCCTGCCCAGCAGGAACTGGAATACAGTGTTCGGGGAGAAGGCCAAATGATATCCTTGAGAGCAGAGATTAAACTTTTCTGTCAT

>36575_36575_1_HK1-FUS_HK1_chr10_71103745_ENST00000298649_FUS_chr16_31199646_ENST00000254108_length(amino acids)=334AA_BP=190
MDCEHSLSLPCRGAEAWEIGIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDSEQDNS
DNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRR
ADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGS

--------------------------------------------------------------
>36575_36575_2_HK1-FUS_HK1_chr10_71103745_ENST00000298649_FUS_chr16_31199646_ENST00000380244_length(transcript)=1270nt_BP=324nt
CCTGGCTCAAAACTCTACCACAACCTGACACTGGGCAAGATGGCCCACCTGTGGCATCCCAGGTTCCTGCCCTGTAAAGAGGAGTCTGGG
TGTATATCCAGATGGACTGTGAGCACAGCCTGAGTTTGCCCTGTCGAGGTGCTGAGGCCTGGGAGATTGGGATTGACAAGTATCTCTATG
CCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAATCCAA
CAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGGCCCTCGGGACCAAGGATCACGTCATGACTCCGAAC
AGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTACAATTGAGTCTGTGGCTGATTACTTCAAGCAGATTG
GTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAGACAGGGAAACTGGCAAGCTGAAGGGAGAGGCAACGG
TCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATGGTAAAGAATTCTCCGGAAATCCTATCAAGGTCTCATTTG
CTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAGGGCGAGGAGGACCCATGGGCCGTGGAGGCTATGGAG
GTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTGGCGGTGGAGGACAGCAGCGAGCTGGTGACTGGAAGTGTC
CTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGTGTAAGGCCCCTAAACCAGATGGCCCAGGAGGGGGAC
CAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCAGAGGAGGCTATGATCGAGGCGGCTACCGGGGCCGCGGCG
GGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCTTTGGCCCTGGCAAGATGGATTCCAGGGGTGAGCACAGAC
AGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGAACAGCTTTTTGTCCTGTACCCAGTGTTACCCTCGTTATT
TTGTAACCTTCCAATTCCTGATCACCCAAGGGTTTTTTTGTGTCGGACTATGTAATTGTAACTATACCTCTGGTTCCCATTAAAAGTGAC

>36575_36575_2_HK1-FUS_HK1_chr10_71103745_ENST00000298649_FUS_chr16_31199646_ENST00000380244_length(amino acids)=334AA_BP=190
MDCEHSLSLPCRGAEAWEIGIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDSEQDNS
DNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRR
ADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGS

--------------------------------------------------------------
>36575_36575_3_HK1-FUS_HK1_chr10_71103745_ENST00000298649_FUS_chr16_31199646_ENST00000568685_length(transcript)=1246nt_BP=324nt
CCTGGCTCAAAACTCTACCACAACCTGACACTGGGCAAGATGGCCCACCTGTGGCATCCCAGGTTCCTGCCCTGTAAAGAGGAGTCTGGG
TGTATATCCAGATGGACTGTGAGCACAGCCTGAGTTTGCCCTGTCGAGGTGCTGAGGCCTGGGAGATTGGGATTGACAAGTATCTCTATG
CCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAATCCAA
CAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGGCCCTCGGGACCAAGGATCACGTCATGACTCCGCAG
AACAGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTACAATTGAGTCTGTGGCTGATTACTTCAAGCAGA
TTGGTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAGACAGGGAAACTGGCAAGCTGAAGGGAGAGGCAA
CGGTCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATGGTAAAGAATTCTCCGGAAATCCTATCAAGGTCTCAT
TTGCTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAGGGCGAGGAGGACCCATGGGCCGTGGAGGCTATG
GAGGTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTGGCGGTGGAGGACAGCAGCGAGCTGGTGACTGGAAGT
GTCCTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGTGTAAGGCCCCTAAACCAGATGGCCCAGGAGGGG
GACCAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCAGAGGAGGCTATGATCGAGGCGGCTACCGGGGCCGCG
GCGGGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCTTTGGCCCTGGCAAGATGGATTCCAGGGGTGAGCACA
GACAGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGAACAGCTTTTTGTCCTGTACCCAGTGTTACCCTCGTT

>36575_36575_3_HK1-FUS_HK1_chr10_71103745_ENST00000298649_FUS_chr16_31199646_ENST00000568685_length(amino acids)=335AA_BP=191
MDCEHSLSLPCRGAEAWEIGIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDSAEQDN
SDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATR
RADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGG

--------------------------------------------------------------
>36575_36575_4_HK1-FUS_HK1_chr10_71103745_ENST00000359426_FUS_chr16_31199646_ENST00000254108_length(transcript)=1480nt_BP=330nt
GAGGAGGAGGAGCCGCCGAGCAGCCGCCGGAGGACCACGGCTCGCCAGGGCTGCGGAGGACCGACCGTCCCCACGCCTGCCGCCCCGCGA
CCCCGACCGCCAGCATGATCGCCGCGCAGCTCCTGGCCTATTACTTCACGGAGCTGAAGGATGACCAGGTCAAAAAGATTGACAAGTATC
TCTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTA
ATCCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGGCCCTCGGGACCAAGGATCACGTCATGACT
CCGAACAGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTACAATTGAGTCTGTGGCTGATTACTTCAAGC
AGATTGGTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAGACAGGGAAACTGGCAAGCTGAAGGGAGAGG
CAACGGTCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATGGTAAAGAATTCTCCGGAAATCCTATCAAGGTCT
CATTTGCTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAGGGCGAGGAGGACCCATGGGCCGTGGAGGCT
ATGGAGGTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTGGCGGTGGAGGACAGCAGCGAGCTGGTGACTGGA
AGTGTCCTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGTGTAAGGCCCCTAAACCAGATGGCCCAGGAG
GGGGACCAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCAGAGGAGGCTATGATCGAGGCGGCTACCGGGGCC
GCGGCGGGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCTTTGGCCCTGGCAAGATGGATTCCAGGGGTGAGC
ACAGACAGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGAACAGCTTTTTGTCCTGTACCCAGTGTTACCCTC
GTTATTTTGTAACCTTCCAATTCCTGATCACCCAAGGGTTTTTTTGTGTCGGACTATGTAATTGTAACTATACCTCTGGTTCCCATTAAA
AGTGACCATTTTAGTTAAATTTTGTTCCTCTTCCCCCTTTTCACTTTCCTGGAAGATCGATGTCCCGATCAGGAAGGTAGAGAGTTTTCC
TGTTCAGATTACCCTGCCCAGCAGGAACTGGAATACAGTGTTCGGGGAGAAGGCCAAATGATATCCTTGAGAGCAGAGATTAAACTTTTC

>36575_36575_4_HK1-FUS_HK1_chr10_71103745_ENST00000359426_FUS_chr16_31199646_ENST00000254108_length(amino acids)=353AA_BP=209
MRRTDRPHACRPATPTASMIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIP
DGSGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDW
FDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE

--------------------------------------------------------------
>36575_36575_5_HK1-FUS_HK1_chr10_71103745_ENST00000359426_FUS_chr16_31199646_ENST00000380244_length(transcript)=1276nt_BP=330nt
GAGGAGGAGGAGCCGCCGAGCAGCCGCCGGAGGACCACGGCTCGCCAGGGCTGCGGAGGACCGACCGTCCCCACGCCTGCCGCCCCGCGA
CCCCGACCGCCAGCATGATCGCCGCGCAGCTCCTGGCCTATTACTTCACGGAGCTGAAGGATGACCAGGTCAAAAAGATTGACAAGTATC
TCTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTA
ATCCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGGCCCTCGGGACCAAGGATCACGTCATGACT
CCGAACAGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTACAATTGAGTCTGTGGCTGATTACTTCAAGC
AGATTGGTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAGACAGGGAAACTGGCAAGCTGAAGGGAGAGG
CAACGGTCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATGGTAAAGAATTCTCCGGAAATCCTATCAAGGTCT
CATTTGCTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAGGGCGAGGAGGACCCATGGGCCGTGGAGGCT
ATGGAGGTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTGGCGGTGGAGGACAGCAGCGAGCTGGTGACTGGA
AGTGTCCTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGTGTAAGGCCCCTAAACCAGATGGCCCAGGAG
GGGGACCAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCAGAGGAGGCTATGATCGAGGCGGCTACCGGGGCC
GCGGCGGGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCTTTGGCCCTGGCAAGATGGATTCCAGGGGTGAGC
ACAGACAGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGAACAGCTTTTTGTCCTGTACCCAGTGTTACCCTC
GTTATTTTGTAACCTTCCAATTCCTGATCACCCAAGGGTTTTTTTGTGTCGGACTATGTAATTGTAACTATACCTCTGGTTCCCATTAAA

>36575_36575_5_HK1-FUS_HK1_chr10_71103745_ENST00000359426_FUS_chr16_31199646_ENST00000380244_length(amino acids)=353AA_BP=209
MRRTDRPHACRPATPTASMIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIP
DGSGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDW
FDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE

--------------------------------------------------------------
>36575_36575_6_HK1-FUS_HK1_chr10_71103745_ENST00000359426_FUS_chr16_31199646_ENST00000568685_length(transcript)=1252nt_BP=330nt
GAGGAGGAGGAGCCGCCGAGCAGCCGCCGGAGGACCACGGCTCGCCAGGGCTGCGGAGGACCGACCGTCCCCACGCCTGCCGCCCCGCGA
CCCCGACCGCCAGCATGATCGCCGCGCAGCTCCTGGCCTATTACTTCACGGAGCTGAAGGATGACCAGGTCAAAAAGATTGACAAGTATC
TCTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTA
ATCCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGGCCCTCGGGACCAAGGATCACGTCATGACT
CCGCAGAACAGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTACAATTGAGTCTGTGGCTGATTACTTCA
AGCAGATTGGTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAGACAGGGAAACTGGCAAGCTGAAGGGAG
AGGCAACGGTCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATGGTAAAGAATTCTCCGGAAATCCTATCAAGG
TCTCATTTGCTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAGGGCGAGGAGGACCCATGGGCCGTGGAG
GCTATGGAGGTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTGGCGGTGGAGGACAGCAGCGAGCTGGTGACT
GGAAGTGTCCTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGTGTAAGGCCCCTAAACCAGATGGCCCAG
GAGGGGGACCAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCAGAGGAGGCTATGATCGAGGCGGCTACCGGG
GCCGCGGCGGGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCTTTGGCCCTGGCAAGATGGATTCCAGGGGTG
AGCACAGACAGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGAACAGCTTTTTGTCCTGTACCCAGTGTTACC

>36575_36575_6_HK1-FUS_HK1_chr10_71103745_ENST00000359426_FUS_chr16_31199646_ENST00000568685_length(amino acids)=354AA_BP=210
MRRTDRPHACRPATPTASMIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIP
DGSGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAID
WFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRN

--------------------------------------------------------------
>36575_36575_7_HK1-FUS_HK1_chr10_71103745_ENST00000360289_FUS_chr16_31199646_ENST00000254108_length(transcript)=1839nt_BP=689nt
AAAACATCTATCTTGCTGTGTTTGGACAGGCCAGCCCCTGAAACATCTTGGGCAATGGAGGGTTAACTTCTCAAAGTTTAATAGGCAAGA
CCAGCAACCATGCAACAAGGACTTCAACTAACCAACTAAAGAACTGTTCCCCAGAGCATTGTTCCTGAGAAGGAAAAGAGTCCAAACACC
TACCCACACCTGCTTTGTGCCAAGAATCCACAGTTGGATTGCAAGGACAGTGTATGTTGTCCTTTTGGAAAAATGAGAGTGAGCCCAAAT
GAAGAACAAGCAAAGGCGTTCAAGACCCAGCTGTTGAGAGTAGAAAAGCAGAAGAAAGGACCCGAGGTCAGCAAGTGCCCTCCCCACAAT
GGGGCAGATCTGCCAGCGAGAATCGGCTACAGCAGCTGAAAAACCAAAACTTCATCTACTTGCTGAAAGTGAGCATTGTTGATGCTCTTG
AGAGCATCAGCCAGGACATTAATGTGCACCACTGTGGTGGCGTGGAAAGATGGCAAAAAGAGCCCTGCATGATTTTATTGACAAGTATCT
CTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAA
TCCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGGCCCTCGGGACCAAGGATCACGTCATGACTC
CGAACAGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTACAATTGAGTCTGTGGCTGATTACTTCAAGCA
GATTGGTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAGACAGGGAAACTGGCAAGCTGAAGGGAGAGGC
AACGGTCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATGGTAAAGAATTCTCCGGAAATCCTATCAAGGTCTC
ATTTGCTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAGGGCGAGGAGGACCCATGGGCCGTGGAGGCTA
TGGAGGTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTGGCGGTGGAGGACAGCAGCGAGCTGGTGACTGGAA
GTGTCCTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGTGTAAGGCCCCTAAACCAGATGGCCCAGGAGG
GGGACCAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCAGAGGAGGCTATGATCGAGGCGGCTACCGGGGCCG
CGGCGGGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCTTTGGCCCTGGCAAGATGGATTCCAGGGGTGAGCA
CAGACAGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGAACAGCTTTTTGTCCTGTACCCAGTGTTACCCTCG
TTATTTTGTAACCTTCCAATTCCTGATCACCCAAGGGTTTTTTTGTGTCGGACTATGTAATTGTAACTATACCTCTGGTTCCCATTAAAA
GTGACCATTTTAGTTAAATTTTGTTCCTCTTCCCCCTTTTCACTTTCCTGGAAGATCGATGTCCCGATCAGGAAGGTAGAGAGTTTTCCT
GTTCAGATTACCCTGCCCAGCAGGAACTGGAATACAGTGTTCGGGGAGAAGGCCAAATGATATCCTTGAGAGCAGAGATTAAACTTTTCT

>36575_36575_7_HK1-FUS_HK1_chr10_71103745_ENST00000360289_FUS_chr16_31199646_ENST00000254108_length(amino acids)=329AA_BP=185
MWWRGKMAKRALHDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDSEQDNSDNNTI
FVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNR
GGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGN

--------------------------------------------------------------
>36575_36575_8_HK1-FUS_HK1_chr10_71103745_ENST00000360289_FUS_chr16_31199646_ENST00000380244_length(transcript)=1635nt_BP=689nt
AAAACATCTATCTTGCTGTGTTTGGACAGGCCAGCCCCTGAAACATCTTGGGCAATGGAGGGTTAACTTCTCAAAGTTTAATAGGCAAGA
CCAGCAACCATGCAACAAGGACTTCAACTAACCAACTAAAGAACTGTTCCCCAGAGCATTGTTCCTGAGAAGGAAAAGAGTCCAAACACC
TACCCACACCTGCTTTGTGCCAAGAATCCACAGTTGGATTGCAAGGACAGTGTATGTTGTCCTTTTGGAAAAATGAGAGTGAGCCCAAAT
GAAGAACAAGCAAAGGCGTTCAAGACCCAGCTGTTGAGAGTAGAAAAGCAGAAGAAAGGACCCGAGGTCAGCAAGTGCCCTCCCCACAAT
GGGGCAGATCTGCCAGCGAGAATCGGCTACAGCAGCTGAAAAACCAAAACTTCATCTACTTGCTGAAAGTGAGCATTGTTGATGCTCTTG
AGAGCATCAGCCAGGACATTAATGTGCACCACTGTGGTGGCGTGGAAAGATGGCAAAAAGAGCCCTGCATGATTTTATTGACAAGTATCT
CTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAA
TCCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGGCCCTCGGGACCAAGGATCACGTCATGACTC
CGAACAGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTACAATTGAGTCTGTGGCTGATTACTTCAAGCA
GATTGGTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAGACAGGGAAACTGGCAAGCTGAAGGGAGAGGC
AACGGTCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATGGTAAAGAATTCTCCGGAAATCCTATCAAGGTCTC
ATTTGCTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAGGGCGAGGAGGACCCATGGGCCGTGGAGGCTA
TGGAGGTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTGGCGGTGGAGGACAGCAGCGAGCTGGTGACTGGAA
GTGTCCTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGTGTAAGGCCCCTAAACCAGATGGCCCAGGAGG
GGGACCAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCAGAGGAGGCTATGATCGAGGCGGCTACCGGGGCCG
CGGCGGGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCTTTGGCCCTGGCAAGATGGATTCCAGGGGTGAGCA
CAGACAGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGAACAGCTTTTTGTCCTGTACCCAGTGTTACCCTCG
TTATTTTGTAACCTTCCAATTCCTGATCACCCAAGGGTTTTTTTGTGTCGGACTATGTAATTGTAACTATACCTCTGGTTCCCATTAAAA

>36575_36575_8_HK1-FUS_HK1_chr10_71103745_ENST00000360289_FUS_chr16_31199646_ENST00000380244_length(amino acids)=329AA_BP=185
MWWRGKMAKRALHDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDSEQDNSDNNTI
FVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNR
GGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGN

--------------------------------------------------------------
>36575_36575_9_HK1-FUS_HK1_chr10_71103745_ENST00000360289_FUS_chr16_31199646_ENST00000568685_length(transcript)=1611nt_BP=689nt
AAAACATCTATCTTGCTGTGTTTGGACAGGCCAGCCCCTGAAACATCTTGGGCAATGGAGGGTTAACTTCTCAAAGTTTAATAGGCAAGA
CCAGCAACCATGCAACAAGGACTTCAACTAACCAACTAAAGAACTGTTCCCCAGAGCATTGTTCCTGAGAAGGAAAAGAGTCCAAACACC
TACCCACACCTGCTTTGTGCCAAGAATCCACAGTTGGATTGCAAGGACAGTGTATGTTGTCCTTTTGGAAAAATGAGAGTGAGCCCAAAT
GAAGAACAAGCAAAGGCGTTCAAGACCCAGCTGTTGAGAGTAGAAAAGCAGAAGAAAGGACCCGAGGTCAGCAAGTGCCCTCCCCACAAT
GGGGCAGATCTGCCAGCGAGAATCGGCTACAGCAGCTGAAAAACCAAAACTTCATCTACTTGCTGAAAGTGAGCATTGTTGATGCTCTTG
AGAGCATCAGCCAGGACATTAATGTGCACCACTGTGGTGGCGTGGAAAGATGGCAAAAAGAGCCCTGCATGATTTTATTGACAAGTATCT
CTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAA
TCCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGGCCCTCGGGACCAAGGATCACGTCATGACTC
CGCAGAACAGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTACAATTGAGTCTGTGGCTGATTACTTCAA
GCAGATTGGTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAGACAGGGAAACTGGCAAGCTGAAGGGAGA
GGCAACGGTCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATGGTAAAGAATTCTCCGGAAATCCTATCAAGGT
CTCATTTGCTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAGGGCGAGGAGGACCCATGGGCCGTGGAGG
CTATGGAGGTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTGGCGGTGGAGGACAGCAGCGAGCTGGTGACTG
GAAGTGTCCTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGTGTAAGGCCCCTAAACCAGATGGCCCAGG
AGGGGGACCAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCAGAGGAGGCTATGATCGAGGCGGCTACCGGGG
CCGCGGCGGGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCTTTGGCCCTGGCAAGATGGATTCCAGGGGTGA
GCACAGACAGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGAACAGCTTTTTGTCCTGTACCCAGTGTTACCC

>36575_36575_9_HK1-FUS_HK1_chr10_71103745_ENST00000360289_FUS_chr16_31199646_ENST00000568685_length(amino acids)=330AA_BP=186
MWWRGKMAKRALHDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDSAEQDNSDNNT
IFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFN
RGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGG

--------------------------------------------------------------
>36575_36575_10_HK1-FUS_HK1_chr10_71103745_ENST00000404387_FUS_chr16_31199646_ENST00000254108_length(transcript)=1388nt_BP=238nt
ATGGGGCAGATCTGCCAGCGAGAATCGGCTACAGCAGCTGAAAAACCAAAACTTCATCTACTTGCTGAAAGTGAGATTGACAAGTATCTC
TATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAAT
CCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGGCCCTCGGGACCAAGGATCACGTCATGACTCC
GAACAGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTACAATTGAGTCTGTGGCTGATTACTTCAAGCAG
ATTGGTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAGACAGGGAAACTGGCAAGCTGAAGGGAGAGGCA
ACGGTCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATGGTAAAGAATTCTCCGGAAATCCTATCAAGGTCTCA
TTTGCTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAGGGCGAGGAGGACCCATGGGCCGTGGAGGCTAT
GGAGGTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTGGCGGTGGAGGACAGCAGCGAGCTGGTGACTGGAAG
TGTCCTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGTGTAAGGCCCCTAAACCAGATGGCCCAGGAGGG
GGACCAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCAGAGGAGGCTATGATCGAGGCGGCTACCGGGGCCGC
GGCGGGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCTTTGGCCCTGGCAAGATGGATTCCAGGGGTGAGCAC
AGACAGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGAACAGCTTTTTGTCCTGTACCCAGTGTTACCCTCGT
TATTTTGTAACCTTCCAATTCCTGATCACCCAAGGGTTTTTTTGTGTCGGACTATGTAATTGTAACTATACCTCTGGTTCCCATTAAAAG
TGACCATTTTAGTTAAATTTTGTTCCTCTTCCCCCTTTTCACTTTCCTGGAAGATCGATGTCCCGATCAGGAAGGTAGAGAGTTTTCCTG
TTCAGATTACCCTGCCCAGCAGGAACTGGAATACAGTGTTCGGGGAGAAGGCCAAATGATATCCTTGAGAGCAGAGATTAAACTTTTCTG

>36575_36575_10_HK1-FUS_HK1_chr10_71103745_ENST00000404387_FUS_chr16_31199646_ENST00000254108_length(amino acids)=339AA_BP=195
MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDS
EQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVS
FATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGG

--------------------------------------------------------------
>36575_36575_11_HK1-FUS_HK1_chr10_71103745_ENST00000404387_FUS_chr16_31199646_ENST00000380244_length(transcript)=1184nt_BP=238nt
ATGGGGCAGATCTGCCAGCGAGAATCGGCTACAGCAGCTGAAAAACCAAAACTTCATCTACTTGCTGAAAGTGAGATTGACAAGTATCTC
TATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAAT
CCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGGCCCTCGGGACCAAGGATCACGTCATGACTCC
GAACAGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTACAATTGAGTCTGTGGCTGATTACTTCAAGCAG
ATTGGTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAGACAGGGAAACTGGCAAGCTGAAGGGAGAGGCA
ACGGTCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATGGTAAAGAATTCTCCGGAAATCCTATCAAGGTCTCA
TTTGCTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAGGGCGAGGAGGACCCATGGGCCGTGGAGGCTAT
GGAGGTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTGGCGGTGGAGGACAGCAGCGAGCTGGTGACTGGAAG
TGTCCTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGTGTAAGGCCCCTAAACCAGATGGCCCAGGAGGG
GGACCAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCAGAGGAGGCTATGATCGAGGCGGCTACCGGGGCCGC
GGCGGGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCTTTGGCCCTGGCAAGATGGATTCCAGGGGTGAGCAC
AGACAGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGAACAGCTTTTTGTCCTGTACCCAGTGTTACCCTCGT
TATTTTGTAACCTTCCAATTCCTGATCACCCAAGGGTTTTTTTGTGTCGGACTATGTAATTGTAACTATACCTCTGGTTCCCATTAAAAG

>36575_36575_11_HK1-FUS_HK1_chr10_71103745_ENST00000404387_FUS_chr16_31199646_ENST00000380244_length(amino acids)=339AA_BP=195
MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDS
EQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVS
FATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGG

--------------------------------------------------------------
>36575_36575_12_HK1-FUS_HK1_chr10_71103745_ENST00000404387_FUS_chr16_31199646_ENST00000568685_length(transcript)=1160nt_BP=238nt
ATGGGGCAGATCTGCCAGCGAGAATCGGCTACAGCAGCTGAAAAACCAAAACTTCATCTACTTGCTGAAAGTGAGATTGACAAGTATCTC
TATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAAT
CCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGGCCCTCGGGACCAAGGATCACGTCATGACTCC
GCAGAACAGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTACAATTGAGTCTGTGGCTGATTACTTCAAG
CAGATTGGTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAGACAGGGAAACTGGCAAGCTGAAGGGAGAG
GCAACGGTCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATGGTAAAGAATTCTCCGGAAATCCTATCAAGGTC
TCATTTGCTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAGGGCGAGGAGGACCCATGGGCCGTGGAGGC
TATGGAGGTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTGGCGGTGGAGGACAGCAGCGAGCTGGTGACTGG
AAGTGTCCTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGTGTAAGGCCCCTAAACCAGATGGCCCAGGA
GGGGGACCAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCAGAGGAGGCTATGATCGAGGCGGCTACCGGGGC
CGCGGCGGGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCTTTGGCCCTGGCAAGATGGATTCCAGGGGTGAG
CACAGACAGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGAACAGCTTTTTGTCCTGTACCCAGTGTTACCCT

>36575_36575_12_HK1-FUS_HK1_chr10_71103745_ENST00000404387_FUS_chr16_31199646_ENST00000568685_length(amino acids)=340AA_BP=196
MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDS
AEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKV
SFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPG

--------------------------------------------------------------
>36575_36575_13_HK1-FUS_HK1_chr10_71103745_ENST00000448642_FUS_chr16_31199646_ENST00000254108_length(transcript)=1870nt_BP=720nt
ATCTATCTTGCTGTGTTTGGACAGGCCAGCCCCTGAAACATCTTGGGCAATGGAGGGTTAACTTCTCAAAGTTTAATAGGCAAGACCAGC
AACCATGCAACAAGAAGATACTCTATAAATGATGATTCAATGAATGCCAAGCCCTGTTCTATGCACTGAAGACCAAAAGAAATAAAAGAC
ATCATTCCTGCTCTGACTTCAACTAACCAACTAAAGAACTGTTCCCCAGAGCATTGTTCCTGAGAAGGAAAAGAGTCCAAACACCTACCC
ACACCTGCTTTGTGCCAAGAATCCACAGTTGGATTGCAAGGACAGTGCGTTCAAGACCCAGCTGTTGAGAGTAGAAAAGCAGAAGAAAGG
ACCCGAGGTCAGCAAGTGCCCTCCCCACAATGGGGCAGATCTGCCAGCGAGAATCGAGACAGGGTCTTGCTATGTTGCCCAGGCTGTTCT
TAAATCCCTGGCGTCAAGTGATCCTCCTGCCTCAGCCTCCTAAAGTGCTGGGATTACAGGCTACAGCAGCTGAAAAACCAAAACTTCATC
TACTTGCTGAAAGTGAGATTGACAAGTATCTCTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGG
AGATGAAGAATGGCCTCTCCCGGGATTTTAATCCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTG
GCCCTCGGGACCAAGGATCACGTCATGACTCCGAACAGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTA
CAATTGAGTCTGTGGCTGATTACTTCAAGCAGATTGGTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAG
ACAGGGAAACTGGCAAGCTGAAGGGAGAGGCAACGGTCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATGGTA
AAGAATTCTCCGGAAATCCTATCAAGGTCTCATTTGCTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAG
GGCGAGGAGGACCCATGGGCCGTGGAGGCTATGGAGGTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTGGCG
GTGGAGGACAGCAGCGAGCTGGTGACTGGAAGTGTCCTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGT
GTAAGGCCCCTAAACCAGATGGCCCAGGAGGGGGACCAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCAGAG
GAGGCTATGATCGAGGCGGCTACCGGGGCCGCGGCGGGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCTTTG
GCCCTGGCAAGATGGATTCCAGGGGTGAGCACAGACAGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGAACA
GCTTTTTGTCCTGTACCCAGTGTTACCCTCGTTATTTTGTAACCTTCCAATTCCTGATCACCCAAGGGTTTTTTTGTGTCGGACTATGTA
ATTGTAACTATACCTCTGGTTCCCATTAAAAGTGACCATTTTAGTTAAATTTTGTTCCTCTTCCCCCTTTTCACTTTCCTGGAAGATCGA
TGTCCCGATCAGGAAGGTAGAGAGTTTTCCTGTTCAGATTACCCTGCCCAGCAGGAACTGGAATACAGTGTTCGGGGAGAAGGCCAAATG

>36575_36575_13_HK1-FUS_HK1_chr10_71103745_ENST00000448642_FUS_chr16_31199646_ENST00000254108_length(amino acids)=370AA_BP=9
MGQICQRESRQGLAMLPRLFLNPWRQVILLPQPPKVLGLQATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDF
NPTATVKMLPTFVRSIPDGSGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGE
ATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDW
KCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGE

--------------------------------------------------------------
>36575_36575_14_HK1-FUS_HK1_chr10_71103745_ENST00000448642_FUS_chr16_31199646_ENST00000380244_length(transcript)=1666nt_BP=720nt
ATCTATCTTGCTGTGTTTGGACAGGCCAGCCCCTGAAACATCTTGGGCAATGGAGGGTTAACTTCTCAAAGTTTAATAGGCAAGACCAGC
AACCATGCAACAAGAAGATACTCTATAAATGATGATTCAATGAATGCCAAGCCCTGTTCTATGCACTGAAGACCAAAAGAAATAAAAGAC
ATCATTCCTGCTCTGACTTCAACTAACCAACTAAAGAACTGTTCCCCAGAGCATTGTTCCTGAGAAGGAAAAGAGTCCAAACACCTACCC
ACACCTGCTTTGTGCCAAGAATCCACAGTTGGATTGCAAGGACAGTGCGTTCAAGACCCAGCTGTTGAGAGTAGAAAAGCAGAAGAAAGG
ACCCGAGGTCAGCAAGTGCCCTCCCCACAATGGGGCAGATCTGCCAGCGAGAATCGAGACAGGGTCTTGCTATGTTGCCCAGGCTGTTCT
TAAATCCCTGGCGTCAAGTGATCCTCCTGCCTCAGCCTCCTAAAGTGCTGGGATTACAGGCTACAGCAGCTGAAAAACCAAAACTTCATC
TACTTGCTGAAAGTGAGATTGACAAGTATCTCTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGG
AGATGAAGAATGGCCTCTCCCGGGATTTTAATCCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTG
GCCCTCGGGACCAAGGATCACGTCATGACTCCGAACAGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATGTTA
CAATTGAGTCTGTGGCTGATTACTTCAAGCAGATTGGTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACACAG
ACAGGGAAACTGGCAAGCTGAAGGGAGAGGCAACGGTCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATGGTA
AAGAATTCTCCGGAAATCCTATCAAGGTCTCATTTGCTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCCGAG
GGCGAGGAGGACCCATGGGCCGTGGAGGCTATGGAGGTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTGGCG
GTGGAGGACAGCAGCGAGCTGGTGACTGGAAGTGTCCTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACCAGT
GTAAGGCCCCTAAACCAGATGGCCCAGGAGGGGGACCAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCAGAG
GAGGCTATGATCGAGGCGGCTACCGGGGCCGCGGCGGGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCTTTG
GCCCTGGCAAGATGGATTCCAGGGGTGAGCACAGACAGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGAACA
GCTTTTTGTCCTGTACCCAGTGTTACCCTCGTTATTTTGTAACCTTCCAATTCCTGATCACCCAAGGGTTTTTTTGTGTCGGACTATGTA

>36575_36575_14_HK1-FUS_HK1_chr10_71103745_ENST00000448642_FUS_chr16_31199646_ENST00000380244_length(amino acids)=370AA_BP=9
MGQICQRESRQGLAMLPRLFLNPWRQVILLPQPPKVLGLQATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDF
NPTATVKMLPTFVRSIPDGSGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGE
ATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDW
KCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGE

--------------------------------------------------------------
>36575_36575_15_HK1-FUS_HK1_chr10_71103745_ENST00000448642_FUS_chr16_31199646_ENST00000568685_length(transcript)=1642nt_BP=720nt
ATCTATCTTGCTGTGTTTGGACAGGCCAGCCCCTGAAACATCTTGGGCAATGGAGGGTTAACTTCTCAAAGTTTAATAGGCAAGACCAGC
AACCATGCAACAAGAAGATACTCTATAAATGATGATTCAATGAATGCCAAGCCCTGTTCTATGCACTGAAGACCAAAAGAAATAAAAGAC
ATCATTCCTGCTCTGACTTCAACTAACCAACTAAAGAACTGTTCCCCAGAGCATTGTTCCTGAGAAGGAAAAGAGTCCAAACACCTACCC
ACACCTGCTTTGTGCCAAGAATCCACAGTTGGATTGCAAGGACAGTGCGTTCAAGACCCAGCTGTTGAGAGTAGAAAAGCAGAAGAAAGG
ACCCGAGGTCAGCAAGTGCCCTCCCCACAATGGGGCAGATCTGCCAGCGAGAATCGAGACAGGGTCTTGCTATGTTGCCCAGGCTGTTCT
TAAATCCCTGGCGTCAAGTGATCCTCCTGCCTCAGCCTCCTAAAGTGCTGGGATTACAGGCTACAGCAGCTGAAAAACCAAAACTTCATC
TACTTGCTGAAAGTGAGATTGACAAGTATCTCTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGG
AGATGAAGAATGGCCTCTCCCGGGATTTTAATCCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTG
GCCCTCGGGACCAAGGATCACGTCATGACTCCGCAGAACAGGATAATTCAGACAACAACACCATCTTTGTGCAAGGCCTGGGTGAGAATG
TTACAATTGAGTCTGTGGCTGATTACTTCAAGCAGATTGGTATTATTAAGACAAACAAGAAAACGGGACAGCCCATGATTAATTTGTACA
CAGACAGGGAAACTGGCAAGCTGAAGGGAGAGGCAACGGTCTCTTTTGATGACCCACCTTCAGCTAAAGCAGCTATTGACTGGTTTGATG
GTAAAGAATTCTCCGGAAATCCTATCAAGGTCTCATTTGCTACTCGCCGGGCAGACTTTAATCGGGGTGGTGGCAATGGTCGTGGAGGCC
GAGGGCGAGGAGGACCCATGGGCCGTGGAGGCTATGGAGGTGGTGGCAGTGGTGGTGGTGGCCGAGGAGGATTTCCCAGTGGAGGTGGTG
GCGGTGGAGGACAGCAGCGAGCTGGTGACTGGAAGTGTCCTAATCCCACCTGTGAGAATATGAACTTCTCTTGGAGGAATGAATGCAACC
AGTGTAAGGCCCCTAAACCAGATGGCCCAGGAGGGGGACCAGGTGGCTCTCACATGGGGGGTAACTACGGGGATGATCGTCGTGGTGGCA
GAGGAGGCTATGATCGAGGCGGCTACCGGGGCCGCGGCGGGGACCGTGGAGGCTTCCGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGCT
TTGGCCCTGGCAAGATGGATTCCAGGGGTGAGCACAGACAGGATCGCAGGGAGAGGCCGTATTAATTAGCCTGGCTCCCCAGGTTCTGGA
ACAGCTTTTTGTCCTGTACCCAGTGTTACCCTCGTTATTTTGTAACCTTCCAATTCCTGATCACCCAAGGGTTTTTTTGTGTCGGACTAT

>36575_36575_15_HK1-FUS_HK1_chr10_71103745_ENST00000448642_FUS_chr16_31199646_ENST00000568685_length(amino acids)=371AA_BP=9
MGQICQRESRQGLAMLPRLFLNPWRQVILLPQPPKVLGLQATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDF
NPTATVKMLPTFVRSIPDGSGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKG
EATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGD
WKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HK1-FUS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for HK1-FUS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for HK1-FUS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHK1C3150343HEMOLYTIC ANEMIA, NONSPHEROCYTIC, DUE TO HEXOKINASE DEFICIENCY3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneHK1C1854449Neuropathy, hereditary motor and sensory, Russe type2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneHK1C4479526RETINITIS PIGMENTOSA 792CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneHK1C0002152Alloxan Diabetes1CTD_human
HgeneHK1C0004134Ataxia1GENOMICS_ENGLAND
HgeneHK1C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneHK1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneHK1C0036341Schizophrenia1PSYGENET
HgeneHK1C0037822Speech Disorders1GENOMICS_ENGLAND
HgeneHK1C0038433Streptozotocin Diabetes1CTD_human
HgeneHK1C0151744Myocardial Ischemia1CTD_human
HgeneHK1C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneHK1C0472792Hemolytic anemia due to hexokinase deficiency1GENOMICS_ENGLAND
HgeneHK1C0520572Enzymopathy1GENOMICS_ENGLAND
HgeneHK1C0557874Global developmental delay1GENOMICS_ENGLAND
HgeneHK1C0852413Abnormal muscle tone1GENOMICS_ENGLAND
HgeneHK1C3665347Visual Impairment1GENOMICS_ENGLAND
HgeneHK1C3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC1842675AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)5UNIPROT
TgeneC3468114Juvenile amyotrophic lateral sclerosis5ORPHANET
TgeneC0002736Amyotrophic Lateral Sclerosis2CTD_human;ORPHANET
TgeneC0206634Liposarcoma, Myxoid2CTD_human;ORPHANET
TgeneC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
TgeneC0497327Dementia1GENOMICS_ENGLAND
TgeneC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
TgeneC3539195TREMOR, HEREDITARY ESSENTIAL, 41CTD_human;UNIPROT
TgeneC3888102Frontotemporal Dementia With Motor Neuron Disease1ORPHANET