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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HK1-UTP23 (FusionGDB2 ID:HG3098TG84294)

Fusion Gene Summary for HK1-UTP23

check button Fusion gene summary
Fusion gene informationFusion gene name: HK1-UTP23
Fusion gene ID: hg3098tg84294
HgeneTgene
Gene symbol

HK1

UTP23

Gene ID

3098

84294

Gene namehexokinase 1UTP23 small subunit processome component
SynonymsHK|HK1-ta|HK1-tb|HK1-tc|HKD|HKI|HMSNR|HXK1|NEDVIBA|RP79|hexokinaseC8orf53
Cytomap('HK1')('UTP23')

10q22.1

8q24.11

Type of geneprotein-codingprotein-coding
Descriptionhexokinase-1brain form hexokinaseglycolytic enzymehexokinase IRhexokinase type Ihexokinase-ArRNA-processing protein UTP23 homologUTP23, small subunit (SSU) processome component, homolog
Modification date2020032820200313
UniProtAcc

P19367

.
Ensembl transtripts involved in fusion geneENST00000494253, ENST00000298649, 
ENST00000359426, ENST00000360289, 
ENST00000404387, ENST00000448642, 
Fusion gene scores* DoF score15 X 16 X 5=12003 X 2 X 3=18
# samples 213
** MAII scorelog2(21/1200*10)=-2.51457317282976
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HK1 [Title/Abstract] AND UTP23 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHK1(71146174)-UTP23(117861127), # samples:1
Anticipated loss of major functional domain due to fusion event.HK1-UTP23 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HK1-UTP23 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HK1-UTP23 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HK1-UTP23 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HK1-UTP23 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
HK1-UTP23 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across UTP23 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1RH-01AHK1chr10

71146174

+UTP23chr8

117861127

+


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Fusion Gene ORF analysis for HK1-UTP23

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000494253ENST00000517820HK1chr10

71146174

+UTP23chr8

117861127

+
3UTR-3CDSENST00000494253ENST00000520733HK1chr10

71146174

+UTP23chr8

117861127

+
3UTR-intronENST00000494253ENST00000309822HK1chr10

71146174

+UTP23chr8

117861127

+
3UTR-intronENST00000494253ENST00000357148HK1chr10

71146174

+UTP23chr8

117861127

+
5CDS-intronENST00000298649ENST00000309822HK1chr10

71146174

+UTP23chr8

117861127

+
5CDS-intronENST00000298649ENST00000357148HK1chr10

71146174

+UTP23chr8

117861127

+
5CDS-intronENST00000359426ENST00000309822HK1chr10

71146174

+UTP23chr8

117861127

+
5CDS-intronENST00000359426ENST00000357148HK1chr10

71146174

+UTP23chr8

117861127

+
5CDS-intronENST00000360289ENST00000309822HK1chr10

71146174

+UTP23chr8

117861127

+
5CDS-intronENST00000360289ENST00000357148HK1chr10

71146174

+UTP23chr8

117861127

+
5CDS-intronENST00000404387ENST00000309822HK1chr10

71146174

+UTP23chr8

117861127

+
5CDS-intronENST00000404387ENST00000357148HK1chr10

71146174

+UTP23chr8

117861127

+
5CDS-intronENST00000448642ENST00000309822HK1chr10

71146174

+UTP23chr8

117861127

+
5CDS-intronENST00000448642ENST00000357148HK1chr10

71146174

+UTP23chr8

117861127

+
Frame-shiftENST00000298649ENST00000517820HK1chr10

71146174

+UTP23chr8

117861127

+
Frame-shiftENST00000359426ENST00000517820HK1chr10

71146174

+UTP23chr8

117861127

+
Frame-shiftENST00000360289ENST00000517820HK1chr10

71146174

+UTP23chr8

117861127

+
Frame-shiftENST00000404387ENST00000517820HK1chr10

71146174

+UTP23chr8

117861127

+
Frame-shiftENST00000448642ENST00000517820HK1chr10

71146174

+UTP23chr8

117861127

+
In-frameENST00000298649ENST00000520733HK1chr10

71146174

+UTP23chr8

117861127

+
In-frameENST00000359426ENST00000520733HK1chr10

71146174

+UTP23chr8

117861127

+
In-frameENST00000360289ENST00000520733HK1chr10

71146174

+UTP23chr8

117861127

+
In-frameENST00000404387ENST00000520733HK1chr10

71146174

+UTP23chr8

117861127

+
In-frameENST00000448642ENST00000520733HK1chr10

71146174

+UTP23chr8

117861127

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360289HK1chr1071146174+ENST00000520733UTP23chr8117861127+259023984812547688
ENST00000448642HK1chr1071146174+ENST00000520733UTP23chr8117861127+262124293892578729
ENST00000404387HK1chr1071146174+ENST00000520733UTP23chr8117861127+2139194702096698
ENST00000298649HK1chr1071146174+ENST00000520733UTP23chr8117861127+222520331012182693
ENST00000359426HK1chr1071146174+ENST00000520733UTP23chr8117861127+22312039502188712

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360289ENST00000520733HK1chr1071146174+UTP23chr8117861127+0.0023418940.99765813
ENST00000448642ENST00000520733HK1chr1071146174+UTP23chr8117861127+0.003701850.99629813
ENST00000404387ENST00000520733HK1chr1071146174+UTP23chr8117861127+0.0030369130.9969631
ENST00000298649ENST00000520733HK1chr1071146174+UTP23chr8117861127+0.0030607820.9969392
ENST00000359426ENST00000520733HK1chr1071146174+UTP23chr8117861127+0.002959430.99704057

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Fusion Genomic Features for HK1-UTP23


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HK1chr1071146174+UTP23chr8117861126+0.0003408560.9996592
HK1chr1071146174+UTP23chr8117861126+0.0003408560.9996592

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HK1-UTP23


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:71146174/chr8:117861127)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HK1

P19367

.
FUNCTION: Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000269|PubMed:1637300, ECO:0000269|PubMed:25316723, ECO:0000269|PubMed:27374331}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+131816_458644917.0DomainHexokinase 1
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+131816_458645918.0DomainHexokinase 1
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+172216_458633906.0DomainHexokinase 1
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+141916_458649922.0DomainHexokinase 1
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318425_426644917.0Nucleotide bindingATP 1
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318532_537644917.0Nucleotide bindingATP 2
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+131884_89644917.0Nucleotide bindingATP 1
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318425_426645918.0Nucleotide bindingATP 1
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318532_537645918.0Nucleotide bindingATP 2
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+131884_89645918.0Nucleotide bindingATP 1
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722425_426633906.0Nucleotide bindingATP 1
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722532_537633906.0Nucleotide bindingATP 2
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+172284_89633906.0Nucleotide bindingATP 1
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419425_426649922.0Nucleotide bindingATP 1
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419532_537649922.0Nucleotide bindingATP 2
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+141984_89649922.0Nucleotide bindingATP 1
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318172_173644917.0RegionSubstrate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+13181_10644917.0RegionMitochondrial-binding peptide (MBP)
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318208_209644917.0RegionSubstrate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318208_447644917.0RegionHexokinase large subdomain 1
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318291_294644917.0RegionSubstrate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318413_415644917.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318532_536644917.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318603_604644917.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318620_621644917.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+131873_207644917.0RegionHexokinase small subdomain 1
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+131884_91644917.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318172_173645918.0RegionSubstrate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+13181_10645918.0RegionMitochondrial-binding peptide (MBP)
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318208_209645918.0RegionSubstrate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318208_447645918.0RegionHexokinase large subdomain 1
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318291_294645918.0RegionSubstrate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318413_415645918.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318532_536645918.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318603_604645918.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318620_621645918.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+131873_207645918.0RegionHexokinase small subdomain 1
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+131884_91645918.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722172_173633906.0RegionSubstrate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+17221_10633906.0RegionMitochondrial-binding peptide (MBP)
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722208_209633906.0RegionSubstrate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722208_447633906.0RegionHexokinase large subdomain 1
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722291_294633906.0RegionSubstrate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722413_415633906.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722532_536633906.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722603_604633906.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722620_621633906.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+172273_207633906.0RegionHexokinase small subdomain 1
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+172284_91633906.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419172_173649922.0RegionSubstrate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+14191_10649922.0RegionMitochondrial-binding peptide (MBP)
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419208_209649922.0RegionSubstrate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419208_447649922.0RegionHexokinase large subdomain 1
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419291_294649922.0RegionSubstrate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419413_415649922.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419532_536649922.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419603_604649922.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419620_621649922.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+141973_207649922.0RegionHexokinase small subdomain 1
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+141984_91649922.0RegionGlucose-6-phosphate 1 binding
TgeneUTP23chr10:71146174chr8:117861127ENST0000030982203209_2130250.0Compositional biasNote=Poly-Lys
TgeneUTP23chr10:71146174chr8:117861127ENST0000035714803209_2130146.0Compositional biasNote=Poly-Lys

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318464_906644917.0DomainHexokinase 2
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318464_906645918.0DomainHexokinase 2
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722464_906633906.0DomainHexokinase 2
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419464_906649922.0DomainHexokinase 2
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318747_748644917.0Nucleotide bindingATP 2
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318784_788644917.0Nucleotide bindingATP 2
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318747_748645918.0Nucleotide bindingATP 2
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318784_788645918.0Nucleotide bindingATP 2
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722747_748633906.0Nucleotide bindingATP 2
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722784_788633906.0Nucleotide bindingATP 2
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419747_748649922.0Nucleotide bindingATP 2
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419784_788649922.0Nucleotide bindingATP 2
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318521_655644917.0RegionHexokinase small subdomain 2
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318656_657644917.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318656_895644917.0RegionHexokinase large subdomain 2
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318682_683644917.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000298649+1318861_863644917.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318521_655645918.0RegionHexokinase small subdomain 2
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318656_657645918.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318656_895645918.0RegionHexokinase large subdomain 2
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318682_683645918.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000359426+1318861_863645918.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722521_655633906.0RegionHexokinase small subdomain 2
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722656_657633906.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722656_895633906.0RegionHexokinase large subdomain 2
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722682_683633906.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000360289+1722861_863633906.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419521_655649922.0RegionHexokinase small subdomain 2
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419656_657649922.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419656_895649922.0RegionHexokinase large subdomain 2
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419682_683649922.0RegionSubstrate 2 binding
HgeneHK1chr10:71146174chr8:117861127ENST00000404387+1419861_863649922.0RegionGlucose-6-phosphate 2 binding


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Fusion Gene Sequence for HK1-UTP23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36585_36585_1_HK1-UTP23_HK1_chr10_71146174_ENST00000298649_UTP23_chr8_117861127_ENST00000520733_length(transcript)=2225nt_BP=2033nt
CCTGGCTCAAAACTCTACCACAACCTGACACTGGGCAAGATGGCCCACCTGTGGCATCCCAGGTTCCTGCCCTGTAAAGAGGAGTCTGGG
TGTATATCCAGATGGACTGTGAGCACAGCCTGAGTTTGCCCTGTCGAGGTGCTGAGGCCTGGGAGATTGGGATTGACAAGTATCTCTATG
CCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAATCCAA
CAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGAAAAGGGAGATTTCATTGCCCTGGATCTTGGTGGGT
CTTCCTTTCGAATTCTGCGGGTGCAAGTGAATCATGAGAAAAACCAGAATGTTCACATGGAGTCCGAGGTTTATGACACCCCAGAGAACA
TCGTGCACGGCAGTGGAAGCCAGCTTTTTGATCATGTTGCTGAGTGCCTGGGAGATTTCATGGAGAAAAGGAAGATCAAGGACAAGAAGT
TACCTGTGGGATTCACGTTTTCTTTTCCTTGCCAACAATCCAAAATAGATGAGGCCATCCTGATCACCTGGACAAAGCGATTTAAAGCGA
GCGGAGTGGAAGGAGCAGATGTGGTCAAACTGCTTAACAAAGCCATCAAAAAGCGAGGGGACTATGATGCCAACATCGTAGCTGTGGTGA
ATGACACAGTGGGCACCATGATGACCTGTGGCTATGACGACCAGCACTGTGAAGTCGGCCTGATCATCGGCACTGGCACCAATGCTTGCT
ACATGGAGGAACTGAGGCACATTGATCTGGTGGAAGGAGACGAGGGGAGGATGTGTATCAATACAGAATGGGGAGCCTTTGGAGACGATG
GATCATTAGAAGACATCCGGACAGAGTTTGACAGGGAGATAGACCGGGGATCCCTCAACCCTGGAAAACAGCTGTTTGAGAAGATGGTCA
GTGGCATGTACTTGGGAGAGCTGGTTCGACTGATCCTAGTCAAGATGGCCAAGGAGGGCCTCTTATTTGAAGGGCGGATCACCCCGGAGC
TGCTCACCCGAGGGAAGTTTAACACCAGTGATGTGTCAGCCATCGAAAAGAATAAGGAAGGCCTCCACAATGCCAAAGAAATCCTGACCC
GCCTGGGAGTGGAGCCGTCCGATGATGACTGTGTCTCAGTCCAGCACGTTTGCACCATTGTCTCATTTCGCTCAGCCAACTTGGTGGCTG
CCACACTGGGCGCCATCTTGAACCGCCTGCGTGATAACAAGGGCACACCCAGGCTGCGGACCACGGTTGGTGTCGACGGATCTCTTTACA
AGACGCACCCACAGTATTCCCGGCGTTTCCACAAGACTCTAAGGCGCTTGGTGCCAGACTCCGATGTGCGCTTCCTCCTCTCGGAGAGTG
GCAGCGGCAAGGGGGCTGCCATGGTGACGGCGGTGGCCTACCGCTTGGCCGAGCAGCACCGGCAGATAGAGGAGACCCTGGCTCATTTCC
ACCTCACCAAGGACATGCTGCTGGAGGTGAAGAAGAGGATGCGGGCCGAGATGGAGCTGGGGCTGAGGAAGCAGACGCACAACAATGCCG
TGGTTAAGATGCTGCCCTCCTTCGTCCGGAGAACTCCCGACGGGACCGAGAATGGTGACTTCTTGGCCCTGGATCTTGGAGGAACCAATT
TCCGTGTGCTGCTGGTGAAAATCCGTAGTGGGAAAAAGAGAACGGTGGAAATGCACAACAAGATCTACGCCATTCCTATTGAAATCATGC
AGGGCACTGGGGAAGAGCTGTTTGATCACATTGTCTCCTGCATCTCTGACTTCTTGGACTACATGGGGATCAAAGGCCCCAGGATGCCTC
TGGGCTTCACGTTCTCATTTCCCTGCCAGCAGACGAGTCTGGACGCGGGAATCTTGATCACGTGGACAAAGGGTTTTAAGGCAACAGACT
GCGTGGGCCACGATGTAGTCACCTTACTAAGGGATGCGATAAAAAGGAGAGAGGGAACAATGGCAAAAGCCTTTGATGAAGCATTTTCCT
CTGAGACAACAGCGGCAATACCTGAAGACCATGAAGCATCTGCTGAGTCCTTTTGTTCCATCTTCTTTCTTCCTGATCTTGATCGCCCCC

>36585_36585_1_HK1-UTP23_HK1_chr10_71146174_ENST00000298649_UTP23_chr8_117861127_ENST00000520733_length(amino acids)=693AA_BP=644
MDCEHSLSLPCRGAEAWEIGIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFR
ILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVE
GADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLE
DIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGV
EPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGK
GAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVL
LVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGH

--------------------------------------------------------------
>36585_36585_2_HK1-UTP23_HK1_chr10_71146174_ENST00000359426_UTP23_chr8_117861127_ENST00000520733_length(transcript)=2231nt_BP=2039nt
GAGGAGGAGGAGCCGCCGAGCAGCCGCCGGAGGACCACGGCTCGCCAGGGCTGCGGAGGACCGACCGTCCCCACGCCTGCCGCCCCGCGA
CCCCGACCGCCAGCATGATCGCCGCGCAGCTCCTGGCCTATTACTTCACGGAGCTGAAGGATGACCAGGTCAAAAAGATTGACAAGTATC
TCTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTA
ATCCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGAAAAGGGAGATTTCATTGCCCTGGATCTTG
GTGGGTCTTCCTTTCGAATTCTGCGGGTGCAAGTGAATCATGAGAAAAACCAGAATGTTCACATGGAGTCCGAGGTTTATGACACCCCAG
AGAACATCGTGCACGGCAGTGGAAGCCAGCTTTTTGATCATGTTGCTGAGTGCCTGGGAGATTTCATGGAGAAAAGGAAGATCAAGGACA
AGAAGTTACCTGTGGGATTCACGTTTTCTTTTCCTTGCCAACAATCCAAAATAGATGAGGCCATCCTGATCACCTGGACAAAGCGATTTA
AAGCGAGCGGAGTGGAAGGAGCAGATGTGGTCAAACTGCTTAACAAAGCCATCAAAAAGCGAGGGGACTATGATGCCAACATCGTAGCTG
TGGTGAATGACACAGTGGGCACCATGATGACCTGTGGCTATGACGACCAGCACTGTGAAGTCGGCCTGATCATCGGCACTGGCACCAATG
CTTGCTACATGGAGGAACTGAGGCACATTGATCTGGTGGAAGGAGACGAGGGGAGGATGTGTATCAATACAGAATGGGGAGCCTTTGGAG
ACGATGGATCATTAGAAGACATCCGGACAGAGTTTGACAGGGAGATAGACCGGGGATCCCTCAACCCTGGAAAACAGCTGTTTGAGAAGA
TGGTCAGTGGCATGTACTTGGGAGAGCTGGTTCGACTGATCCTAGTCAAGATGGCCAAGGAGGGCCTCTTATTTGAAGGGCGGATCACCC
CGGAGCTGCTCACCCGAGGGAAGTTTAACACCAGTGATGTGTCAGCCATCGAAAAGAATAAGGAAGGCCTCCACAATGCCAAAGAAATCC
TGACCCGCCTGGGAGTGGAGCCGTCCGATGATGACTGTGTCTCAGTCCAGCACGTTTGCACCATTGTCTCATTTCGCTCAGCCAACTTGG
TGGCTGCCACACTGGGCGCCATCTTGAACCGCCTGCGTGATAACAAGGGCACACCCAGGCTGCGGACCACGGTTGGTGTCGACGGATCTC
TTTACAAGACGCACCCACAGTATTCCCGGCGTTTCCACAAGACTCTAAGGCGCTTGGTGCCAGACTCCGATGTGCGCTTCCTCCTCTCGG
AGAGTGGCAGCGGCAAGGGGGCTGCCATGGTGACGGCGGTGGCCTACCGCTTGGCCGAGCAGCACCGGCAGATAGAGGAGACCCTGGCTC
ATTTCCACCTCACCAAGGACATGCTGCTGGAGGTGAAGAAGAGGATGCGGGCCGAGATGGAGCTGGGGCTGAGGAAGCAGACGCACAACA
ATGCCGTGGTTAAGATGCTGCCCTCCTTCGTCCGGAGAACTCCCGACGGGACCGAGAATGGTGACTTCTTGGCCCTGGATCTTGGAGGAA
CCAATTTCCGTGTGCTGCTGGTGAAAATCCGTAGTGGGAAAAAGAGAACGGTGGAAATGCACAACAAGATCTACGCCATTCCTATTGAAA
TCATGCAGGGCACTGGGGAAGAGCTGTTTGATCACATTGTCTCCTGCATCTCTGACTTCTTGGACTACATGGGGATCAAAGGCCCCAGGA
TGCCTCTGGGCTTCACGTTCTCATTTCCCTGCCAGCAGACGAGTCTGGACGCGGGAATCTTGATCACGTGGACAAAGGGTTTTAAGGCAA
CAGACTGCGTGGGCCACGATGTAGTCACCTTACTAAGGGATGCGATAAAAAGGAGAGAGGGAACAATGGCAAAAGCCTTTGATGAAGCAT
TTTCCTCTGAGACAACAGCGGCAATACCTGAAGACCATGAAGCATCTGCTGAGTCCTTTTGTTCCATCTTCTTTCTTCCTGATCTTGATC

>36585_36585_2_HK1-UTP23_HK1_chr10_71146174_ENST00000359426_UTP23_chr8_117861127_ENST00000520733_length(amino acids)=712AA_BP=663
MRRTDRPHACRPATPTASMIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIP
DGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSK
IDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDE
GRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAI
EKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLR
RLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDG
TENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD

--------------------------------------------------------------
>36585_36585_3_HK1-UTP23_HK1_chr10_71146174_ENST00000360289_UTP23_chr8_117861127_ENST00000520733_length(transcript)=2590nt_BP=2398nt
AAAACATCTATCTTGCTGTGTTTGGACAGGCCAGCCCCTGAAACATCTTGGGCAATGGAGGGTTAACTTCTCAAAGTTTAATAGGCAAGA
CCAGCAACCATGCAACAAGGACTTCAACTAACCAACTAAAGAACTGTTCCCCAGAGCATTGTTCCTGAGAAGGAAAAGAGTCCAAACACC
TACCCACACCTGCTTTGTGCCAAGAATCCACAGTTGGATTGCAAGGACAGTGTATGTTGTCCTTTTGGAAAAATGAGAGTGAGCCCAAAT
GAAGAACAAGCAAAGGCGTTCAAGACCCAGCTGTTGAGAGTAGAAAAGCAGAAGAAAGGACCCGAGGTCAGCAAGTGCCCTCCCCACAAT
GGGGCAGATCTGCCAGCGAGAATCGGCTACAGCAGCTGAAAAACCAAAACTTCATCTACTTGCTGAAAGTGAGCATTGTTGATGCTCTTG
AGAGCATCAGCCAGGACATTAATGTGCACCACTGTGGTGGCGTGGAAAGATGGCAAAAAGAGCCCTGCATGATTTTATTGACAAGTATCT
CTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAA
TCCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGAAAAGGGAGATTTCATTGCCCTGGATCTTGG
TGGGTCTTCCTTTCGAATTCTGCGGGTGCAAGTGAATCATGAGAAAAACCAGAATGTTCACATGGAGTCCGAGGTTTATGACACCCCAGA
GAACATCGTGCACGGCAGTGGAAGCCAGCTTTTTGATCATGTTGCTGAGTGCCTGGGAGATTTCATGGAGAAAAGGAAGATCAAGGACAA
GAAGTTACCTGTGGGATTCACGTTTTCTTTTCCTTGCCAACAATCCAAAATAGATGAGGCCATCCTGATCACCTGGACAAAGCGATTTAA
AGCGAGCGGAGTGGAAGGAGCAGATGTGGTCAAACTGCTTAACAAAGCCATCAAAAAGCGAGGGGACTATGATGCCAACATCGTAGCTGT
GGTGAATGACACAGTGGGCACCATGATGACCTGTGGCTATGACGACCAGCACTGTGAAGTCGGCCTGATCATCGGCACTGGCACCAATGC
TTGCTACATGGAGGAACTGAGGCACATTGATCTGGTGGAAGGAGACGAGGGGAGGATGTGTATCAATACAGAATGGGGAGCCTTTGGAGA
CGATGGATCATTAGAAGACATCCGGACAGAGTTTGACAGGGAGATAGACCGGGGATCCCTCAACCCTGGAAAACAGCTGTTTGAGAAGAT
GGTCAGTGGCATGTACTTGGGAGAGCTGGTTCGACTGATCCTAGTCAAGATGGCCAAGGAGGGCCTCTTATTTGAAGGGCGGATCACCCC
GGAGCTGCTCACCCGAGGGAAGTTTAACACCAGTGATGTGTCAGCCATCGAAAAGAATAAGGAAGGCCTCCACAATGCCAAAGAAATCCT
GACCCGCCTGGGAGTGGAGCCGTCCGATGATGACTGTGTCTCAGTCCAGCACGTTTGCACCATTGTCTCATTTCGCTCAGCCAACTTGGT
GGCTGCCACACTGGGCGCCATCTTGAACCGCCTGCGTGATAACAAGGGCACACCCAGGCTGCGGACCACGGTTGGTGTCGACGGATCTCT
TTACAAGACGCACCCACAGTATTCCCGGCGTTTCCACAAGACTCTAAGGCGCTTGGTGCCAGACTCCGATGTGCGCTTCCTCCTCTCGGA
GAGTGGCAGCGGCAAGGGGGCTGCCATGGTGACGGCGGTGGCCTACCGCTTGGCCGAGCAGCACCGGCAGATAGAGGAGACCCTGGCTCA
TTTCCACCTCACCAAGGACATGCTGCTGGAGGTGAAGAAGAGGATGCGGGCCGAGATGGAGCTGGGGCTGAGGAAGCAGACGCACAACAA
TGCCGTGGTTAAGATGCTGCCCTCCTTCGTCCGGAGAACTCCCGACGGGACCGAGAATGGTGACTTCTTGGCCCTGGATCTTGGAGGAAC
CAATTTCCGTGTGCTGCTGGTGAAAATCCGTAGTGGGAAAAAGAGAACGGTGGAAATGCACAACAAGATCTACGCCATTCCTATTGAAAT
CATGCAGGGCACTGGGGAAGAGCTGTTTGATCACATTGTCTCCTGCATCTCTGACTTCTTGGACTACATGGGGATCAAAGGCCCCAGGAT
GCCTCTGGGCTTCACGTTCTCATTTCCCTGCCAGCAGACGAGTCTGGACGCGGGAATCTTGATCACGTGGACAAAGGGTTTTAAGGCAAC
AGACTGCGTGGGCCACGATGTAGTCACCTTACTAAGGGATGCGATAAAAAGGAGAGAGGGAACAATGGCAAAAGCCTTTGATGAAGCATT
TTCCTCTGAGACAACAGCGGCAATACCTGAAGACCATGAAGCATCTGCTGAGTCCTTTTGTTCCATCTTCTTTCTTCCTGATCTTGATCG

>36585_36585_3_HK1-UTP23_HK1_chr10_71146174_ENST00000360289_UTP23_chr8_117861127_ENST00000520733_length(amino acids)=688AA_BP=639
MWWRGKMAKRALHDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQ
VNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVV
KLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTE
FDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDD
DCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMV
TAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIR
SGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTL

--------------------------------------------------------------
>36585_36585_4_HK1-UTP23_HK1_chr10_71146174_ENST00000404387_UTP23_chr8_117861127_ENST00000520733_length(transcript)=2139nt_BP=1947nt
ATGGGGCAGATCTGCCAGCGAGAATCGGCTACAGCAGCTGAAAAACCAAAACTTCATCTACTTGCTGAAAGTGAGATTGACAAGTATCTC
TATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAAT
CCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGAAAAGGGAGATTTCATTGCCCTGGATCTTGGT
GGGTCTTCCTTTCGAATTCTGCGGGTGCAAGTGAATCATGAGAAAAACCAGAATGTTCACATGGAGTCCGAGGTTTATGACACCCCAGAG
AACATCGTGCACGGCAGTGGAAGCCAGCTTTTTGATCATGTTGCTGAGTGCCTGGGAGATTTCATGGAGAAAAGGAAGATCAAGGACAAG
AAGTTACCTGTGGGATTCACGTTTTCTTTTCCTTGCCAACAATCCAAAATAGATGAGGCCATCCTGATCACCTGGACAAAGCGATTTAAA
GCGAGCGGAGTGGAAGGAGCAGATGTGGTCAAACTGCTTAACAAAGCCATCAAAAAGCGAGGGGACTATGATGCCAACATCGTAGCTGTG
GTGAATGACACAGTGGGCACCATGATGACCTGTGGCTATGACGACCAGCACTGTGAAGTCGGCCTGATCATCGGCACTGGCACCAATGCT
TGCTACATGGAGGAACTGAGGCACATTGATCTGGTGGAAGGAGACGAGGGGAGGATGTGTATCAATACAGAATGGGGAGCCTTTGGAGAC
GATGGATCATTAGAAGACATCCGGACAGAGTTTGACAGGGAGATAGACCGGGGATCCCTCAACCCTGGAAAACAGCTGTTTGAGAAGATG
GTCAGTGGCATGTACTTGGGAGAGCTGGTTCGACTGATCCTAGTCAAGATGGCCAAGGAGGGCCTCTTATTTGAAGGGCGGATCACCCCG
GAGCTGCTCACCCGAGGGAAGTTTAACACCAGTGATGTGTCAGCCATCGAAAAGAATAAGGAAGGCCTCCACAATGCCAAAGAAATCCTG
ACCCGCCTGGGAGTGGAGCCGTCCGATGATGACTGTGTCTCAGTCCAGCACGTTTGCACCATTGTCTCATTTCGCTCAGCCAACTTGGTG
GCTGCCACACTGGGCGCCATCTTGAACCGCCTGCGTGATAACAAGGGCACACCCAGGCTGCGGACCACGGTTGGTGTCGACGGATCTCTT
TACAAGACGCACCCACAGTATTCCCGGCGTTTCCACAAGACTCTAAGGCGCTTGGTGCCAGACTCCGATGTGCGCTTCCTCCTCTCGGAG
AGTGGCAGCGGCAAGGGGGCTGCCATGGTGACGGCGGTGGCCTACCGCTTGGCCGAGCAGCACCGGCAGATAGAGGAGACCCTGGCTCAT
TTCCACCTCACCAAGGACATGCTGCTGGAGGTGAAGAAGAGGATGCGGGCCGAGATGGAGCTGGGGCTGAGGAAGCAGACGCACAACAAT
GCCGTGGTTAAGATGCTGCCCTCCTTCGTCCGGAGAACTCCCGACGGGACCGAGAATGGTGACTTCTTGGCCCTGGATCTTGGAGGAACC
AATTTCCGTGTGCTGCTGGTGAAAATCCGTAGTGGGAAAAAGAGAACGGTGGAAATGCACAACAAGATCTACGCCATTCCTATTGAAATC
ATGCAGGGCACTGGGGAAGAGCTGTTTGATCACATTGTCTCCTGCATCTCTGACTTCTTGGACTACATGGGGATCAAAGGCCCCAGGATG
CCTCTGGGCTTCACGTTCTCATTTCCCTGCCAGCAGACGAGTCTGGACGCGGGAATCTTGATCACGTGGACAAAGGGTTTTAAGGCAACA
GACTGCGTGGGCCACGATGTAGTCACCTTACTAAGGGATGCGATAAAAAGGAGAGAGGGAACAATGGCAAAAGCCTTTGATGAAGCATTT
TCCTCTGAGACAACAGCGGCAATACCTGAAGACCATGAAGCATCTGCTGAGTCCTTTTGTTCCATCTTCTTTCTTCCTGATCTTGATCGC

>36585_36585_4_HK1-UTP23_HK1_chr10_71146174_ENST00000404387_UTP23_chr8_117861127_ENST00000520733_length(amino acids)=698AA_BP=649
MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLG
GSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFK
ASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGD
DGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEIL
TRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSE
SGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGT
NFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKAT

--------------------------------------------------------------
>36585_36585_5_HK1-UTP23_HK1_chr10_71146174_ENST00000448642_UTP23_chr8_117861127_ENST00000520733_length(transcript)=2621nt_BP=2429nt
ATCTATCTTGCTGTGTTTGGACAGGCCAGCCCCTGAAACATCTTGGGCAATGGAGGGTTAACTTCTCAAAGTTTAATAGGCAAGACCAGC
AACCATGCAACAAGAAGATACTCTATAAATGATGATTCAATGAATGCCAAGCCCTGTTCTATGCACTGAAGACCAAAAGAAATAAAAGAC
ATCATTCCTGCTCTGACTTCAACTAACCAACTAAAGAACTGTTCCCCAGAGCATTGTTCCTGAGAAGGAAAAGAGTCCAAACACCTACCC
ACACCTGCTTTGTGCCAAGAATCCACAGTTGGATTGCAAGGACAGTGCGTTCAAGACCCAGCTGTTGAGAGTAGAAAAGCAGAAGAAAGG
ACCCGAGGTCAGCAAGTGCCCTCCCCACAATGGGGCAGATCTGCCAGCGAGAATCGAGACAGGGTCTTGCTATGTTGCCCAGGCTGTTCT
TAAATCCCTGGCGTCAAGTGATCCTCCTGCCTCAGCCTCCTAAAGTGCTGGGATTACAGGCTACAGCAGCTGAAAAACCAAAACTTCATC
TACTTGCTGAAAGTGAGATTGACAAGTATCTCTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATGACTCGCTTCAGGAAGG
AGATGAAGAATGGCCTCTCCCGGGATTTTAATCCAACAGCCACAGTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTG
AAAAGGGAGATTTCATTGCCCTGGATCTTGGTGGGTCTTCCTTTCGAATTCTGCGGGTGCAAGTGAATCATGAGAAAAACCAGAATGTTC
ACATGGAGTCCGAGGTTTATGACACCCCAGAGAACATCGTGCACGGCAGTGGAAGCCAGCTTTTTGATCATGTTGCTGAGTGCCTGGGAG
ATTTCATGGAGAAAAGGAAGATCAAGGACAAGAAGTTACCTGTGGGATTCACGTTTTCTTTTCCTTGCCAACAATCCAAAATAGATGAGG
CCATCCTGATCACCTGGACAAAGCGATTTAAAGCGAGCGGAGTGGAAGGAGCAGATGTGGTCAAACTGCTTAACAAAGCCATCAAAAAGC
GAGGGGACTATGATGCCAACATCGTAGCTGTGGTGAATGACACAGTGGGCACCATGATGACCTGTGGCTATGACGACCAGCACTGTGAAG
TCGGCCTGATCATCGGCACTGGCACCAATGCTTGCTACATGGAGGAACTGAGGCACATTGATCTGGTGGAAGGAGACGAGGGGAGGATGT
GTATCAATACAGAATGGGGAGCCTTTGGAGACGATGGATCATTAGAAGACATCCGGACAGAGTTTGACAGGGAGATAGACCGGGGATCCC
TCAACCCTGGAAAACAGCTGTTTGAGAAGATGGTCAGTGGCATGTACTTGGGAGAGCTGGTTCGACTGATCCTAGTCAAGATGGCCAAGG
AGGGCCTCTTATTTGAAGGGCGGATCACCCCGGAGCTGCTCACCCGAGGGAAGTTTAACACCAGTGATGTGTCAGCCATCGAAAAGAATA
AGGAAGGCCTCCACAATGCCAAAGAAATCCTGACCCGCCTGGGAGTGGAGCCGTCCGATGATGACTGTGTCTCAGTCCAGCACGTTTGCA
CCATTGTCTCATTTCGCTCAGCCAACTTGGTGGCTGCCACACTGGGCGCCATCTTGAACCGCCTGCGTGATAACAAGGGCACACCCAGGC
TGCGGACCACGGTTGGTGTCGACGGATCTCTTTACAAGACGCACCCACAGTATTCCCGGCGTTTCCACAAGACTCTAAGGCGCTTGGTGC
CAGACTCCGATGTGCGCTTCCTCCTCTCGGAGAGTGGCAGCGGCAAGGGGGCTGCCATGGTGACGGCGGTGGCCTACCGCTTGGCCGAGC
AGCACCGGCAGATAGAGGAGACCCTGGCTCATTTCCACCTCACCAAGGACATGCTGCTGGAGGTGAAGAAGAGGATGCGGGCCGAGATGG
AGCTGGGGCTGAGGAAGCAGACGCACAACAATGCCGTGGTTAAGATGCTGCCCTCCTTCGTCCGGAGAACTCCCGACGGGACCGAGAATG
GTGACTTCTTGGCCCTGGATCTTGGAGGAACCAATTTCCGTGTGCTGCTGGTGAAAATCCGTAGTGGGAAAAAGAGAACGGTGGAAATGC
ACAACAAGATCTACGCCATTCCTATTGAAATCATGCAGGGCACTGGGGAAGAGCTGTTTGATCACATTGTCTCCTGCATCTCTGACTTCT
TGGACTACATGGGGATCAAAGGCCCCAGGATGCCTCTGGGCTTCACGTTCTCATTTCCCTGCCAGCAGACGAGTCTGGACGCGGGAATCT
TGATCACGTGGACAAAGGGTTTTAAGGCAACAGACTGCGTGGGCCACGATGTAGTCACCTTACTAAGGGATGCGATAAAAAGGAGAGAGG
GAACAATGGCAAAAGCCTTTGATGAAGCATTTTCCTCTGAGACAACAGCGGCAATACCTGAAGACCATGAAGCATCTGCTGAGTCCTTTT
GTTCCATCTTCTTTCTTCCTGATCTTGATCGCCCCCTGATGCATCTTCATCCTGAATAAAAATGACCCCCAAAAAGCTGACAAAACAAGT

>36585_36585_5_HK1-UTP23_HK1_chr10_71146174_ENST00000448642_UTP23_chr8_117861127_ENST00000520733_length(amino acids)=729AA_BP=680
MGQICQRESRQGLAMLPRLFLNPWRQVILLPQPPKVLGLQATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDF
NPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKD
KKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTN
ACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRIT
PELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGS
LYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHN
NAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPR
MPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREGTMAKAFDEAFSSETTAAIPEDHEASAESFCSIFFLPDLD

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Fusion Gene PPI Analysis for HK1-UTP23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HK1-UTP23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HK1-UTP23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHK1C3150343HEMOLYTIC ANEMIA, NONSPHEROCYTIC, DUE TO HEXOKINASE DEFICIENCY3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneHK1C1854449Neuropathy, hereditary motor and sensory, Russe type2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneHK1C4479526RETINITIS PIGMENTOSA 792CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneHK1C0002152Alloxan Diabetes1CTD_human
HgeneHK1C0004134Ataxia1GENOMICS_ENGLAND
HgeneHK1C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneHK1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneHK1C0036341Schizophrenia1PSYGENET
HgeneHK1C0037822Speech Disorders1GENOMICS_ENGLAND
HgeneHK1C0038433Streptozotocin Diabetes1CTD_human
HgeneHK1C0151744Myocardial Ischemia1CTD_human
HgeneHK1C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneHK1C0472792Hemolytic anemia due to hexokinase deficiency1GENOMICS_ENGLAND
HgeneHK1C0520572Enzymopathy1GENOMICS_ENGLAND
HgeneHK1C0557874Global developmental delay1GENOMICS_ENGLAND
HgeneHK1C0852413Abnormal muscle tone1GENOMICS_ENGLAND
HgeneHK1C3665347Visual Impairment1GENOMICS_ENGLAND
HgeneHK1C3714756Intellectual Disability1GENOMICS_ENGLAND