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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AOAH-ELMO1 (FusionGDB2 ID:HG313TG9844)

Fusion Gene Summary for AOAH-ELMO1

check button Fusion gene summary
Fusion gene informationFusion gene name: AOAH-ELMO1
Fusion gene ID: hg313tg9844
HgeneTgene
Gene symbol

AOAH

ELMO1

Gene ID

313

9844

Gene nameacyloxyacyl hydrolaseengulfment and cell motility 1
Synonyms-CED-12|CED12|ELMO-1
Cytomap('AOAH')('ELMO1')

7p14.2

7p14.2-p14.1

Type of geneprotein-codingprotein-coding
Descriptionacyloxyacyl hydrolaseacyloxyacyl hydrolase (neutrophil)engulfment and cell motility protein 1ced-12 homolog 1
Modification date2020031320200313
UniProtAcc

P28039

.
Ensembl transtripts involved in fusion geneENST00000258749, ENST00000431169, 
ENST00000535891, ENST00000491444, 
ENST00000538464, 
ENST00000258749, 
ENST00000431169, ENST00000491444, 
ENST00000535891, ENST00000538464, 
Fusion gene scores* DoF score5 X 6 X 4=12017 X 13 X 9=1989
# samples 618
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/1989*10)=-3.46597446450407
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AOAH [Title/Abstract] AND ELMO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAOAH(36698771)-ELMO1(36934622), # samples:2
Anticipated loss of major functional domain due to fusion event.AOAH-ELMO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AOAH-ELMO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AOAH-ELMO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AOAH-ELMO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAOAH

GO:0006631

fatty acid metabolic process

1883828|29343645

HgeneAOAH

GO:0009104

lipopolysaccharide catabolic process

1883828|29343645


check buttonFusion gene breakpoints across AOAH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ELMO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-7140-01AAOAHchr7

36698770

-ELMO1chr7

36934621

-
ChimerDB4LUSCTCGA-77-7140-01AAOAHchr7

36698771

-ELMO1chr7

36934622

-
ChimerDB4LUSCTCGA-77-7140AOAHchr7

36698771

-ELMO1chr7

36934622

-


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Fusion Gene ORF analysis for AOAH-ELMO1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000258749ENST00000310758AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000258749ENST00000310758AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000258749ENST00000396040AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000258749ENST00000396040AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000258749ENST00000396045AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000258749ENST00000396045AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000258749ENST00000442504AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000258749ENST00000442504AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000258749ENST00000448602AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000258749ENST00000448602AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000431169ENST00000310758AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000431169ENST00000310758AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000431169ENST00000396040AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000431169ENST00000396040AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000431169ENST00000396045AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000431169ENST00000396045AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000431169ENST00000442504AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000431169ENST00000442504AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000431169ENST00000448602AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000431169ENST00000448602AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000535891ENST00000310758AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000535891ENST00000310758AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000535891ENST00000396040AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000535891ENST00000396040AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000535891ENST00000396045AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000535891ENST00000396045AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000535891ENST00000442504AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000535891ENST00000442504AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000535891ENST00000448602AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-5UTRENST00000535891ENST00000448602AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-intronENST00000258749ENST00000479447AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-intronENST00000258749ENST00000479447AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-intronENST00000431169ENST00000479447AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-intronENST00000431169ENST00000479447AOAHchr7

36698771

-ELMO1chr7

36934622

-
5CDS-intronENST00000535891ENST00000479447AOAHchr7

36698770

-ELMO1chr7

36934621

-
5CDS-intronENST00000535891ENST00000479447AOAHchr7

36698771

-ELMO1chr7

36934622

-
In-frameENST00000258749ENST00000341056AOAHchr7

36698770

-ELMO1chr7

36934621

-
In-frameENST00000258749ENST00000341056AOAHchr7

36698771

-ELMO1chr7

36934622

-
In-frameENST00000431169ENST00000341056AOAHchr7

36698770

-ELMO1chr7

36934621

-
In-frameENST00000431169ENST00000341056AOAHchr7

36698771

-ELMO1chr7

36934622

-
In-frameENST00000535891ENST00000341056AOAHchr7

36698770

-ELMO1chr7

36934621

-
In-frameENST00000535891ENST00000341056AOAHchr7

36698771

-ELMO1chr7

36934622

-
intron-3CDSENST00000491444ENST00000341056AOAHchr7

36698770

-ELMO1chr7

36934621

-
intron-3CDSENST00000491444ENST00000341056AOAHchr7

36698771

-ELMO1chr7

36934622

-
intron-3CDSENST00000538464ENST00000341056AOAHchr7

36698770

-ELMO1chr7

36934621

-
intron-3CDSENST00000538464ENST00000341056AOAHchr7

36698771

-ELMO1chr7

36934622

-
intron-5UTRENST00000491444ENST00000310758AOAHchr7

36698770

-ELMO1chr7

36934621

-
intron-5UTRENST00000491444ENST00000310758AOAHchr7

36698771

-ELMO1chr7

36934622

-
intron-5UTRENST00000491444ENST00000396040AOAHchr7

36698770

-ELMO1chr7

36934621

-
intron-5UTRENST00000491444ENST00000396040AOAHchr7

36698771

-ELMO1chr7

36934622

-
intron-5UTRENST00000491444ENST00000396045AOAHchr7

36698770

-ELMO1chr7

36934621

-
intron-5UTRENST00000491444ENST00000396045AOAHchr7

36698771

-ELMO1chr7

36934622

-
intron-5UTRENST00000491444ENST00000442504AOAHchr7

36698770

-ELMO1chr7

36934621

-
intron-5UTRENST00000491444ENST00000442504AOAHchr7

36698771

-ELMO1chr7

36934622

-
intron-5UTRENST00000491444ENST00000448602AOAHchr7

36698770

-ELMO1chr7

36934621

-
intron-5UTRENST00000491444ENST00000448602AOAHchr7

36698771

-ELMO1chr7

36934622

-
intron-5UTRENST00000538464ENST00000310758AOAHchr7

36698770

-ELMO1chr7

36934621

-
intron-5UTRENST00000538464ENST00000310758AOAHchr7

36698771

-ELMO1chr7

36934622

-
intron-5UTRENST00000538464ENST00000396040AOAHchr7

36698770

-ELMO1chr7

36934621

-
intron-5UTRENST00000538464ENST00000396040AOAHchr7

36698771

-ELMO1chr7

36934622

-
intron-5UTRENST00000538464ENST00000396045AOAHchr7

36698770

-ELMO1chr7

36934621

-
intron-5UTRENST00000538464ENST00000396045AOAHchr7

36698771

-ELMO1chr7

36934622

-
intron-5UTRENST00000538464ENST00000442504AOAHchr7

36698770

-ELMO1chr7

36934621

-
intron-5UTRENST00000538464ENST00000442504AOAHchr7

36698771

-ELMO1chr7

36934622

-
intron-5UTRENST00000538464ENST00000448602AOAHchr7

36698770

-ELMO1chr7

36934621

-
intron-5UTRENST00000538464ENST00000448602AOAHchr7

36698771

-ELMO1chr7

36934622

-
intron-intronENST00000491444ENST00000479447AOAHchr7

36698770

-ELMO1chr7

36934621

-
intron-intronENST00000491444ENST00000479447AOAHchr7

36698771

-ELMO1chr7

36934622

-
intron-intronENST00000538464ENST00000479447AOAHchr7

36698770

-ELMO1chr7

36934621

-
intron-intronENST00000538464ENST00000479447AOAHchr7

36698771

-ELMO1chr7

36934622

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000535891AOAHchr736698771-ENST00000341056ELMO1chr736934622-26376954011441346
ENST00000258749AOAHchr736698771-ENST00000341056ELMO1chr736934622-27327904001536378
ENST00000431169AOAHchr736698771-ENST00000341056ELMO1chr736934622-26336913011437378
ENST00000535891AOAHchr736698770-ENST00000341056ELMO1chr736934621-26376954011441346
ENST00000258749AOAHchr736698770-ENST00000341056ELMO1chr736934621-27327904001536378
ENST00000431169AOAHchr736698770-ENST00000341056ELMO1chr736934621-26336913011437378

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535891ENST00000341056AOAHchr736698771-ELMO1chr736934622-0.0016861110.9983139
ENST00000258749ENST00000341056AOAHchr736698771-ELMO1chr736934622-0.0012080550.998792
ENST00000431169ENST00000341056AOAHchr736698771-ELMO1chr736934622-0.0013105280.9986895
ENST00000535891ENST00000341056AOAHchr736698770-ELMO1chr736934621-0.0016861110.9983139
ENST00000258749ENST00000341056AOAHchr736698770-ELMO1chr736934621-0.0012080550.998792
ENST00000431169ENST00000341056AOAHchr736698770-ELMO1chr736934621-0.0013105280.9986895

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Fusion Genomic Features for AOAH-ELMO1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AOAH-ELMO1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:36698771/chr7:36934622)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AOAH

P28039

.
FUNCTION: Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:8089145, PubMed:29343645). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity). {ECO:0000250|UniProtKB:O35298, ECO:0000269|PubMed:1883828, ECO:0000269|PubMed:29343645, ECO:0000269|PubMed:8089145}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAOAHchr7:36698770chr7:36934621ENST00000258749-42137_118130576.0DomainSaposin B-type
HgeneAOAHchr7:36698771chr7:36934622ENST00000258749-42137_118130576.0DomainSaposin B-type
HgeneAOAHchr7:36698770chr7:36934621ENST00000258749-42138_70130576.0RegionImportant for enzyme activity%2C localization to cytoplasmic vesicles%2C and protein stability
HgeneAOAHchr7:36698770chr7:36934621ENST00000535891-32038_7098544.0RegionImportant for enzyme activity%2C localization to cytoplasmic vesicles%2C and protein stability
HgeneAOAHchr7:36698771chr7:36934622ENST00000258749-42138_70130576.0RegionImportant for enzyme activity%2C localization to cytoplasmic vesicles%2C and protein stability
HgeneAOAHchr7:36698771chr7:36934622ENST00000535891-32038_7098544.0RegionImportant for enzyme activity%2C localization to cytoplasmic vesicles%2C and protein stability
TgeneELMO1chr7:36698770chr7:36934621ENST000003107581522555_676479728.0DomainNote=PH
TgeneELMO1chr7:36698770chr7:36934621ENST00000341056310319_492181430.0DomainELMO
TgeneELMO1chr7:36698770chr7:36934621ENST00000341056310555_676181430.0DomainNote=PH
TgeneELMO1chr7:36698770chr7:36934621ENST0000039604007319_4920248.0DomainELMO
TgeneELMO1chr7:36698770chr7:36934621ENST0000039604007555_6760248.0DomainNote=PH
TgeneELMO1chr7:36698770chr7:36934621ENST0000039604507319_4920248.0DomainELMO
TgeneELMO1chr7:36698770chr7:36934621ENST0000039604507555_6760248.0DomainNote=PH
TgeneELMO1chr7:36698770chr7:36934621ENST000004425041522555_676479728.0DomainNote=PH
TgeneELMO1chr7:36698770chr7:36934621ENST000004486021522555_676479728.0DomainNote=PH
TgeneELMO1chr7:36698771chr7:36934622ENST000003107581522555_676479728.0DomainNote=PH
TgeneELMO1chr7:36698771chr7:36934622ENST00000341056310319_492181430.0DomainELMO
TgeneELMO1chr7:36698771chr7:36934622ENST00000341056310555_676181430.0DomainNote=PH
TgeneELMO1chr7:36698771chr7:36934622ENST0000039604007319_4920248.0DomainELMO
TgeneELMO1chr7:36698771chr7:36934622ENST0000039604007555_6760248.0DomainNote=PH
TgeneELMO1chr7:36698771chr7:36934622ENST0000039604507319_4920248.0DomainELMO
TgeneELMO1chr7:36698771chr7:36934622ENST0000039604507555_6760248.0DomainNote=PH
TgeneELMO1chr7:36698771chr7:36934622ENST000004425041522555_676479728.0DomainNote=PH
TgeneELMO1chr7:36698771chr7:36934622ENST000004486021522555_676479728.0DomainNote=PH
TgeneELMO1chr7:36698770chr7:36934621ENST000003107581522707_714479728.0MotifNote=SH3-binding
TgeneELMO1chr7:36698770chr7:36934621ENST00000341056310707_714181430.0MotifNote=SH3-binding
TgeneELMO1chr7:36698770chr7:36934621ENST0000039604007707_7140248.0MotifNote=SH3-binding
TgeneELMO1chr7:36698770chr7:36934621ENST0000039604507707_7140248.0MotifNote=SH3-binding
TgeneELMO1chr7:36698770chr7:36934621ENST000004425041522707_714479728.0MotifNote=SH3-binding
TgeneELMO1chr7:36698770chr7:36934621ENST000004486021522707_714479728.0MotifNote=SH3-binding
TgeneELMO1chr7:36698771chr7:36934622ENST000003107581522707_714479728.0MotifNote=SH3-binding
TgeneELMO1chr7:36698771chr7:36934622ENST00000341056310707_714181430.0MotifNote=SH3-binding
TgeneELMO1chr7:36698771chr7:36934622ENST0000039604007707_7140248.0MotifNote=SH3-binding
TgeneELMO1chr7:36698771chr7:36934622ENST0000039604507707_7140248.0MotifNote=SH3-binding
TgeneELMO1chr7:36698771chr7:36934622ENST000004425041522707_714479728.0MotifNote=SH3-binding
TgeneELMO1chr7:36698771chr7:36934622ENST000004486021522707_714479728.0MotifNote=SH3-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAOAHchr7:36698770chr7:36934621ENST00000535891-32037_11898544.0DomainSaposin B-type
HgeneAOAHchr7:36698771chr7:36934622ENST00000535891-32037_11898544.0DomainSaposin B-type
HgeneAOAHchr7:36698770chr7:36934621ENST00000258749-421173_177130576.0RegionLipopolysaccharide binding
HgeneAOAHchr7:36698770chr7:36934621ENST00000535891-320173_17798544.0RegionLipopolysaccharide binding
HgeneAOAHchr7:36698771chr7:36934622ENST00000258749-421173_177130576.0RegionLipopolysaccharide binding
HgeneAOAHchr7:36698771chr7:36934622ENST00000535891-320173_17798544.0RegionLipopolysaccharide binding
TgeneELMO1chr7:36698770chr7:36934621ENST000003107581522319_492479728.0DomainELMO
TgeneELMO1chr7:36698770chr7:36934621ENST000004425041522319_492479728.0DomainELMO
TgeneELMO1chr7:36698770chr7:36934621ENST000004486021522319_492479728.0DomainELMO
TgeneELMO1chr7:36698771chr7:36934622ENST000003107581522319_492479728.0DomainELMO
TgeneELMO1chr7:36698771chr7:36934622ENST000004425041522319_492479728.0DomainELMO
TgeneELMO1chr7:36698771chr7:36934622ENST000004486021522319_492479728.0DomainELMO


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Fusion Gene Sequence for AOAH-ELMO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5107_5107_1_AOAH-ELMO1_AOAH_chr7_36698770_ENST00000258749_ELMO1_chr7_36934621_ENST00000341056_length(transcript)=2732nt_BP=790nt
ACAGATCAGTTCCGGCAAGCCTCGAGGCTCACGGGGTTTATGCACACTAACTTCACTGAGCCAGGGAGCACGGAAGTTGTGCCACTGTGC
AACTTGGGTTTTCTTTATCCTGCAGTCTTTACCTCAGCAGAACCGCACACCACAGACTCCCTCCAGCTCTTTGTGTGTGGCTCTCTCAGG
GTCCAACAAGAGCAAGCTGTGGGTCTGTGAGTGTTTATGTGTGCTTTTATTCACTTCACACTTATTGAAAAGTGTGTATGTGAGAGGGTG
GGGTGTGTGTGTCAAAGAGAGTGAGGAAGAGAAGGAGAGAGAGATCAATTGATTCTGCAGCCTCAGCTCCAGCATCCCTCAGTTGGGAGC
TTCCAAAGCCGGGTGATCACTTGGGGTGCATAGCTCGGAGATGCAGTCCCCCTGGAAAATCCTTACGGTGGCGCCTCTATTCTTGCTCCT
GTCTCTTCAGTCCTCGGCCTCTCCAGCCAACGATGACCAGTCCAGGCCCAGCCTCTCGAATGGGCACACCTGTGTAGGGTGTGTGCTGGT
GGTGTCTGTAATAGAACAGCTTGCTCAAGTTCACAACTCGACGGTCCAGGCCTCGATGGAGAGACTGTGCAGCTACCTGCCTGAAAAACT
GTTCTTGAAAACCACCTGCTATTTAGTCATTGACAAGTTTGGATCAGACATCATAAAACTGCTTAGCGCAGATATGAATGCTGATGTGGT
ATGTCACACTCTGGAGTTTTGTAAACAGAACACTGGCCAACCATTGTGTCATCTCTACCCTCTTCCCAAGGTAATGCAGGTGGTGAAGGA
GCAGGTTATGAGAGCACTTACAACCAAGCCTAGCTCCCTGGACCAGTTCAAGAGCAAACTGCAGAACCTGAGCTACACTGAGATCCTGAA
AATCCGCCAGTCCGAGAGGATGAACCAGGAAGATTTCCAGTCCCGCCCGATTTTGGAACTAAAGGAGAAGATTCAGCCAGAAATCTTAGA
GCTGATCAAACAGCAACGCCTGAACCGCCTTGTGGAAGGGACCTGCTTTAGGAAACTCAATGCCCGGCGGAGGCAAGACAAGTTTTGGTA
TTGTCGGCTTTCGCCAAATCACAAAGTCCTGCATTACGGAGACTTAGAAGAGAGTCCTCAGGGAGAAGTGCCCCACGATTCCTTGCAGGA
CAAACTGCCGGTGGCAGATATCAAAGCCGTGGTGACGGGAAAGGACTGCCCTCATATGAAAGAGAAAGGTGCCCTTAAACAAAACAAGGA
GGTGCTTGAACTCGCTTTCTCCATCTTGTATGACTCAAACTGCCAACTGAACTTCATCGCTCCTGACAAGCATGAGTACTGTATCTGGAC
GGATGGACTGAATGCGCTACTCGGGAAGGACATGATGAGCGACCTGACGCGGAATGACCTGGACACCCTGCTCAGCATGGAAATCAAGCT
CCGCCTCCTGGACCTGGAAAACATCCAGATCCCTGACGCACCTCCGCCGATTCCCAAGGAGCCCAGCAACTATGACTTCGTCTATGACTG
TAACTGAAGTGGCCGGGCCCAGACATGCCCCTTCCAAAACTGGAACACCTAGCTAACAGGAGAGAGGAATGAAAACACACCCACGCCTTG
GAACCGTCCTTTGGTAAAGGGAAGCTGTGGGTCCACATTCCCTTCAGCATCACCTCTAGCCCTGGCAACTTTCAGCCCCTAGCTGGCATC
TTGCTCACCGCCCTGATTCTGTTCCTCGGCTCCACTGCTTCAGGTCACTTCCCATGGCTGCAGTCCACTGGTGGGACAAGAGCAAAGCCC
ACTGCCAGTAAGAAGGCCAAAGGGCCCTTCCATCCTAGCCCTCTGCAGGCATGCCCTTCCTTCCCTTGGGCAGGAAAGCCAGCAGCCCCA
GACTGCCCAAAAACTTGCCCACCAGACCAAGGGCAGTGCCCCAAGGCCCCTGTCTGGAGGAAATGGCCTAGCTATTTGATGAGAAGACCA
AACCCCACATCCTCCTTTCCCCTCTCTCTAGAATCATCTCGCACCACCAGTTACACTTGAATTAAGATCTGCGCTCAAATCTCCTCCCAC
CTCTCTCCCTGCTTTTGCCTTGCTCTGTTCCTCTTTGGTCCCAAGAGCAGCAGCCGCAGCCTCCTCGTGATCCTCCCTAGCATAAATTTC
CCAAACAGTCCACAGGTCCCATGCCCACTTTGCGTCTGCACTGTGATCGTGACAAATCTTCCCTCCTCACCAGCTAGTCTGGGGTTTCCT
CTCCCTGCCCCAGGCCAGAACTGCCTTCTTCATTTCCACCCACGCTCCCAGCCTCTTAGCTGAAAGCACAAATGGTGAAATCAGTAGTCT
CGCTCCATCTCTAATAGACTAAACCTAAATGCCTCTAGGACGGACTGTTGCTATCCAAGCGTTTGGTGTTACCTTCTCCTGGGAGGTCCT
GCTGCAACTCAAGTTCCACAGGATGGTCAAGCTGTCAGACATCCAAGTTTACATCATTGTAATTATTACTGGTATTTACAATTTGCAAGA
GTTTTGGGTTAGTTTTTTTTTTTTTTTTTGCTTTGTTTTTGTACAAAAGAGTCTAACATTTTTTGCCAAACAGATATATATTTAATGAAA
AGAAGAGATACATAAATGTGTGAATTTCCAGTTTTTTTTTAATTATTTTAATCCCAAACATCTTCCTGAAAATAACATTCCCTTAAACAT

>5107_5107_1_AOAH-ELMO1_AOAH_chr7_36698770_ENST00000258749_ELMO1_chr7_36934621_ENST00000341056_length(amino acids)=378AA_BP=130
MQSPWKILTVAPLFLLLSLQSSASPANDDQSRPSLSNGHTCVGCVLVVSVIEQLAQVHNSTVQASMERLCSYLPEKLFLKTTCYLVIDKF
GSDIIKLLSADMNADVVCHTLEFCKQNTGQPLCHLYPLPKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQ
SRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTG
KDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDA

--------------------------------------------------------------
>5107_5107_2_AOAH-ELMO1_AOAH_chr7_36698770_ENST00000431169_ELMO1_chr7_36934621_ENST00000341056_length(transcript)=2633nt_BP=691nt
TTTCTTTATCCTGCAGTCTTTACCTCAGCAGAACCGCACACCACAGACTCCCTCCAGCTCTTTGTGTGTGGCTCTCTCAGGGTCCAACAA
GAGCAAGCTGTGGGTCTGTGAGTGTTTATGTGTGCTTTTATTCACTTCACACTTATTGAAAAGTGTGTATGTGAGAGGGTGGGGTGTGTG
TGTCAAAGAGAGTGAGGAAGAGAAGGAGAGAGAGATCAATTGATTCTGCAGCCTCAGCTCCAGCATCCCTCAGTTGGGAGCTTCCAAAGC
CGGGTGATCACTTGGGGTGCATAGCTCGGAGATGCAGTCCCCCTGGAAAATCCTTACGGTGGCGCCTCTATTCTTGCTCCTGTCTCTTCA
GTCCTCGGCCTCTCCAGCCAACGATGACCAGTCCAGGCCCAGCCTCTCGAATGGGCACACCTGTGTAGGGTGTGTGCTGGTGGTGTCTGT
AATAGAACAGCTTGCTCAAGTTCACAACTCGACGGTCCAGGCCTCGATGGAGAGACTGTGCAGCTACCTGCCTGAAAAACTGTTCTTGAA
AACCACCTGCTATTTAGTCATTGACAAGTTTGGATCAGACATCATAAAACTGCTTAGCGCAGATATGAATGCTGATGTGGTATGTCACAC
TCTGGAGTTTTGTAAACAGAACACTGGCCAACCATTGTGTCATCTCTACCCTCTTCCCAAGGTAATGCAGGTGGTGAAGGAGCAGGTTAT
GAGAGCACTTACAACCAAGCCTAGCTCCCTGGACCAGTTCAAGAGCAAACTGCAGAACCTGAGCTACACTGAGATCCTGAAAATCCGCCA
GTCCGAGAGGATGAACCAGGAAGATTTCCAGTCCCGCCCGATTTTGGAACTAAAGGAGAAGATTCAGCCAGAAATCTTAGAGCTGATCAA
ACAGCAACGCCTGAACCGCCTTGTGGAAGGGACCTGCTTTAGGAAACTCAATGCCCGGCGGAGGCAAGACAAGTTTTGGTATTGTCGGCT
TTCGCCAAATCACAAAGTCCTGCATTACGGAGACTTAGAAGAGAGTCCTCAGGGAGAAGTGCCCCACGATTCCTTGCAGGACAAACTGCC
GGTGGCAGATATCAAAGCCGTGGTGACGGGAAAGGACTGCCCTCATATGAAAGAGAAAGGTGCCCTTAAACAAAACAAGGAGGTGCTTGA
ACTCGCTTTCTCCATCTTGTATGACTCAAACTGCCAACTGAACTTCATCGCTCCTGACAAGCATGAGTACTGTATCTGGACGGATGGACT
GAATGCGCTACTCGGGAAGGACATGATGAGCGACCTGACGCGGAATGACCTGGACACCCTGCTCAGCATGGAAATCAAGCTCCGCCTCCT
GGACCTGGAAAACATCCAGATCCCTGACGCACCTCCGCCGATTCCCAAGGAGCCCAGCAACTATGACTTCGTCTATGACTGTAACTGAAG
TGGCCGGGCCCAGACATGCCCCTTCCAAAACTGGAACACCTAGCTAACAGGAGAGAGGAATGAAAACACACCCACGCCTTGGAACCGTCC
TTTGGTAAAGGGAAGCTGTGGGTCCACATTCCCTTCAGCATCACCTCTAGCCCTGGCAACTTTCAGCCCCTAGCTGGCATCTTGCTCACC
GCCCTGATTCTGTTCCTCGGCTCCACTGCTTCAGGTCACTTCCCATGGCTGCAGTCCACTGGTGGGACAAGAGCAAAGCCCACTGCCAGT
AAGAAGGCCAAAGGGCCCTTCCATCCTAGCCCTCTGCAGGCATGCCCTTCCTTCCCTTGGGCAGGAAAGCCAGCAGCCCCAGACTGCCCA
AAAACTTGCCCACCAGACCAAGGGCAGTGCCCCAAGGCCCCTGTCTGGAGGAAATGGCCTAGCTATTTGATGAGAAGACCAAACCCCACA
TCCTCCTTTCCCCTCTCTCTAGAATCATCTCGCACCACCAGTTACACTTGAATTAAGATCTGCGCTCAAATCTCCTCCCACCTCTCTCCC
TGCTTTTGCCTTGCTCTGTTCCTCTTTGGTCCCAAGAGCAGCAGCCGCAGCCTCCTCGTGATCCTCCCTAGCATAAATTTCCCAAACAGT
CCACAGGTCCCATGCCCACTTTGCGTCTGCACTGTGATCGTGACAAATCTTCCCTCCTCACCAGCTAGTCTGGGGTTTCCTCTCCCTGCC
CCAGGCCAGAACTGCCTTCTTCATTTCCACCCACGCTCCCAGCCTCTTAGCTGAAAGCACAAATGGTGAAATCAGTAGTCTCGCTCCATC
TCTAATAGACTAAACCTAAATGCCTCTAGGACGGACTGTTGCTATCCAAGCGTTTGGTGTTACCTTCTCCTGGGAGGTCCTGCTGCAACT
CAAGTTCCACAGGATGGTCAAGCTGTCAGACATCCAAGTTTACATCATTGTAATTATTACTGGTATTTACAATTTGCAAGAGTTTTGGGT
TAGTTTTTTTTTTTTTTTTTGCTTTGTTTTTGTACAAAAGAGTCTAACATTTTTTGCCAAACAGATATATATTTAATGAAAAGAAGAGAT
ACATAAATGTGTGAATTTCCAGTTTTTTTTTAATTATTTTAATCCCAAACATCTTCCTGAAAATAACATTCCCTTAAACATGCTGTGGAA

>5107_5107_2_AOAH-ELMO1_AOAH_chr7_36698770_ENST00000431169_ELMO1_chr7_36934621_ENST00000341056_length(amino acids)=378AA_BP=130
MQSPWKILTVAPLFLLLSLQSSASPANDDQSRPSLSNGHTCVGCVLVVSVIEQLAQVHNSTVQASMERLCSYLPEKLFLKTTCYLVIDKF
GSDIIKLLSADMNADVVCHTLEFCKQNTGQPLCHLYPLPKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQ
SRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTG
KDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDA

--------------------------------------------------------------
>5107_5107_3_AOAH-ELMO1_AOAH_chr7_36698770_ENST00000535891_ELMO1_chr7_36934621_ENST00000341056_length(transcript)=2637nt_BP=695nt
AACAGATCAGTTCCGGCAAGCCTCGAGGCTCACGGGGTTTATGCACACTAACTTCACTGAGCCAGGGAGCACGGAAGTTGTGCCACTGTG
CAACTTGGGTTTTCTTTATCCTGCAGTCTTTACCTCAGCAGAACCGCACACCACAGACTCCCTCCAGCTCTTTGTGTGTGGCTCTCTCAG
GGTCCAACAAGAGCAAGCTGTGGGTCTGTGAGTGTTTATGTGTGCTTTTATTCACTTCACACTTATTGAAAAGTGTGTATGTGAGAGGGT
GGGGTGTGTGTGTCAAAGAGAGTGAGGAAGAGAAGGAGAGAGAGATCAATTGATTCTGCAGCCTCAGCTCCAGCATCCCTCAGTTGGGAG
CTTCCAAAGCCGGGTGATCACTTGGGGTGCATAGCTCGGAGATGCAGTCCCCCTGGAAAATCCTTACGGTGGCGCCTCTATTCTTGCTCC
TGTCTCTTCAGTCCTCGGCCTCTCCAGCCAACGATGACCAGTCCAGGCCCAGCCTCTCGAATGGGCACACCTGTGTAGAAAAACTGTTCT
TGAAAACCACCTGCTATTTAGTCATTGACAAGTTTGGATCAGACATCATAAAACTGCTTAGCGCAGATATGAATGCTGATGTGGTATGTC
ACACTCTGGAGTTTTGTAAACAGAACACTGGCCAACCATTGTGTCATCTCTACCCTCTTCCCAAGGTAATGCAGGTGGTGAAGGAGCAGG
TTATGAGAGCACTTACAACCAAGCCTAGCTCCCTGGACCAGTTCAAGAGCAAACTGCAGAACCTGAGCTACACTGAGATCCTGAAAATCC
GCCAGTCCGAGAGGATGAACCAGGAAGATTTCCAGTCCCGCCCGATTTTGGAACTAAAGGAGAAGATTCAGCCAGAAATCTTAGAGCTGA
TCAAACAGCAACGCCTGAACCGCCTTGTGGAAGGGACCTGCTTTAGGAAACTCAATGCCCGGCGGAGGCAAGACAAGTTTTGGTATTGTC
GGCTTTCGCCAAATCACAAAGTCCTGCATTACGGAGACTTAGAAGAGAGTCCTCAGGGAGAAGTGCCCCACGATTCCTTGCAGGACAAAC
TGCCGGTGGCAGATATCAAAGCCGTGGTGACGGGAAAGGACTGCCCTCATATGAAAGAGAAAGGTGCCCTTAAACAAAACAAGGAGGTGC
TTGAACTCGCTTTCTCCATCTTGTATGACTCAAACTGCCAACTGAACTTCATCGCTCCTGACAAGCATGAGTACTGTATCTGGACGGATG
GACTGAATGCGCTACTCGGGAAGGACATGATGAGCGACCTGACGCGGAATGACCTGGACACCCTGCTCAGCATGGAAATCAAGCTCCGCC
TCCTGGACCTGGAAAACATCCAGATCCCTGACGCACCTCCGCCGATTCCCAAGGAGCCCAGCAACTATGACTTCGTCTATGACTGTAACT
GAAGTGGCCGGGCCCAGACATGCCCCTTCCAAAACTGGAACACCTAGCTAACAGGAGAGAGGAATGAAAACACACCCACGCCTTGGAACC
GTCCTTTGGTAAAGGGAAGCTGTGGGTCCACATTCCCTTCAGCATCACCTCTAGCCCTGGCAACTTTCAGCCCCTAGCTGGCATCTTGCT
CACCGCCCTGATTCTGTTCCTCGGCTCCACTGCTTCAGGTCACTTCCCATGGCTGCAGTCCACTGGTGGGACAAGAGCAAAGCCCACTGC
CAGTAAGAAGGCCAAAGGGCCCTTCCATCCTAGCCCTCTGCAGGCATGCCCTTCCTTCCCTTGGGCAGGAAAGCCAGCAGCCCCAGACTG
CCCAAAAACTTGCCCACCAGACCAAGGGCAGTGCCCCAAGGCCCCTGTCTGGAGGAAATGGCCTAGCTATTTGATGAGAAGACCAAACCC
CACATCCTCCTTTCCCCTCTCTCTAGAATCATCTCGCACCACCAGTTACACTTGAATTAAGATCTGCGCTCAAATCTCCTCCCACCTCTC
TCCCTGCTTTTGCCTTGCTCTGTTCCTCTTTGGTCCCAAGAGCAGCAGCCGCAGCCTCCTCGTGATCCTCCCTAGCATAAATTTCCCAAA
CAGTCCACAGGTCCCATGCCCACTTTGCGTCTGCACTGTGATCGTGACAAATCTTCCCTCCTCACCAGCTAGTCTGGGGTTTCCTCTCCC
TGCCCCAGGCCAGAACTGCCTTCTTCATTTCCACCCACGCTCCCAGCCTCTTAGCTGAAAGCACAAATGGTGAAATCAGTAGTCTCGCTC
CATCTCTAATAGACTAAACCTAAATGCCTCTAGGACGGACTGTTGCTATCCAAGCGTTTGGTGTTACCTTCTCCTGGGAGGTCCTGCTGC
AACTCAAGTTCCACAGGATGGTCAAGCTGTCAGACATCCAAGTTTACATCATTGTAATTATTACTGGTATTTACAATTTGCAAGAGTTTT
GGGTTAGTTTTTTTTTTTTTTTTTGCTTTGTTTTTGTACAAAAGAGTCTAACATTTTTTGCCAAACAGATATATATTTAATGAAAAGAAG
AGATACATAAATGTGTGAATTTCCAGTTTTTTTTTAATTATTTTAATCCCAAACATCTTCCTGAAAATAACATTCCCTTAAACATGCTGT

>5107_5107_3_AOAH-ELMO1_AOAH_chr7_36698770_ENST00000535891_ELMO1_chr7_36934621_ENST00000341056_length(amino acids)=346AA_BP=98
MQSPWKILTVAPLFLLLSLQSSASPANDDQSRPSLSNGHTCVEKLFLKTTCYLVIDKFGSDIIKLLSADMNADVVCHTLEFCKQNTGQPL
CHLYPLPKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRPILELKEKIQPEILELIKQQRLNRLVEGTC
FRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQ

--------------------------------------------------------------
>5107_5107_4_AOAH-ELMO1_AOAH_chr7_36698771_ENST00000258749_ELMO1_chr7_36934622_ENST00000341056_length(transcript)=2732nt_BP=790nt
ACAGATCAGTTCCGGCAAGCCTCGAGGCTCACGGGGTTTATGCACACTAACTTCACTGAGCCAGGGAGCACGGAAGTTGTGCCACTGTGC
AACTTGGGTTTTCTTTATCCTGCAGTCTTTACCTCAGCAGAACCGCACACCACAGACTCCCTCCAGCTCTTTGTGTGTGGCTCTCTCAGG
GTCCAACAAGAGCAAGCTGTGGGTCTGTGAGTGTTTATGTGTGCTTTTATTCACTTCACACTTATTGAAAAGTGTGTATGTGAGAGGGTG
GGGTGTGTGTGTCAAAGAGAGTGAGGAAGAGAAGGAGAGAGAGATCAATTGATTCTGCAGCCTCAGCTCCAGCATCCCTCAGTTGGGAGC
TTCCAAAGCCGGGTGATCACTTGGGGTGCATAGCTCGGAGATGCAGTCCCCCTGGAAAATCCTTACGGTGGCGCCTCTATTCTTGCTCCT
GTCTCTTCAGTCCTCGGCCTCTCCAGCCAACGATGACCAGTCCAGGCCCAGCCTCTCGAATGGGCACACCTGTGTAGGGTGTGTGCTGGT
GGTGTCTGTAATAGAACAGCTTGCTCAAGTTCACAACTCGACGGTCCAGGCCTCGATGGAGAGACTGTGCAGCTACCTGCCTGAAAAACT
GTTCTTGAAAACCACCTGCTATTTAGTCATTGACAAGTTTGGATCAGACATCATAAAACTGCTTAGCGCAGATATGAATGCTGATGTGGT
ATGTCACACTCTGGAGTTTTGTAAACAGAACACTGGCCAACCATTGTGTCATCTCTACCCTCTTCCCAAGGTAATGCAGGTGGTGAAGGA
GCAGGTTATGAGAGCACTTACAACCAAGCCTAGCTCCCTGGACCAGTTCAAGAGCAAACTGCAGAACCTGAGCTACACTGAGATCCTGAA
AATCCGCCAGTCCGAGAGGATGAACCAGGAAGATTTCCAGTCCCGCCCGATTTTGGAACTAAAGGAGAAGATTCAGCCAGAAATCTTAGA
GCTGATCAAACAGCAACGCCTGAACCGCCTTGTGGAAGGGACCTGCTTTAGGAAACTCAATGCCCGGCGGAGGCAAGACAAGTTTTGGTA
TTGTCGGCTTTCGCCAAATCACAAAGTCCTGCATTACGGAGACTTAGAAGAGAGTCCTCAGGGAGAAGTGCCCCACGATTCCTTGCAGGA
CAAACTGCCGGTGGCAGATATCAAAGCCGTGGTGACGGGAAAGGACTGCCCTCATATGAAAGAGAAAGGTGCCCTTAAACAAAACAAGGA
GGTGCTTGAACTCGCTTTCTCCATCTTGTATGACTCAAACTGCCAACTGAACTTCATCGCTCCTGACAAGCATGAGTACTGTATCTGGAC
GGATGGACTGAATGCGCTACTCGGGAAGGACATGATGAGCGACCTGACGCGGAATGACCTGGACACCCTGCTCAGCATGGAAATCAAGCT
CCGCCTCCTGGACCTGGAAAACATCCAGATCCCTGACGCACCTCCGCCGATTCCCAAGGAGCCCAGCAACTATGACTTCGTCTATGACTG
TAACTGAAGTGGCCGGGCCCAGACATGCCCCTTCCAAAACTGGAACACCTAGCTAACAGGAGAGAGGAATGAAAACACACCCACGCCTTG
GAACCGTCCTTTGGTAAAGGGAAGCTGTGGGTCCACATTCCCTTCAGCATCACCTCTAGCCCTGGCAACTTTCAGCCCCTAGCTGGCATC
TTGCTCACCGCCCTGATTCTGTTCCTCGGCTCCACTGCTTCAGGTCACTTCCCATGGCTGCAGTCCACTGGTGGGACAAGAGCAAAGCCC
ACTGCCAGTAAGAAGGCCAAAGGGCCCTTCCATCCTAGCCCTCTGCAGGCATGCCCTTCCTTCCCTTGGGCAGGAAAGCCAGCAGCCCCA
GACTGCCCAAAAACTTGCCCACCAGACCAAGGGCAGTGCCCCAAGGCCCCTGTCTGGAGGAAATGGCCTAGCTATTTGATGAGAAGACCA
AACCCCACATCCTCCTTTCCCCTCTCTCTAGAATCATCTCGCACCACCAGTTACACTTGAATTAAGATCTGCGCTCAAATCTCCTCCCAC
CTCTCTCCCTGCTTTTGCCTTGCTCTGTTCCTCTTTGGTCCCAAGAGCAGCAGCCGCAGCCTCCTCGTGATCCTCCCTAGCATAAATTTC
CCAAACAGTCCACAGGTCCCATGCCCACTTTGCGTCTGCACTGTGATCGTGACAAATCTTCCCTCCTCACCAGCTAGTCTGGGGTTTCCT
CTCCCTGCCCCAGGCCAGAACTGCCTTCTTCATTTCCACCCACGCTCCCAGCCTCTTAGCTGAAAGCACAAATGGTGAAATCAGTAGTCT
CGCTCCATCTCTAATAGACTAAACCTAAATGCCTCTAGGACGGACTGTTGCTATCCAAGCGTTTGGTGTTACCTTCTCCTGGGAGGTCCT
GCTGCAACTCAAGTTCCACAGGATGGTCAAGCTGTCAGACATCCAAGTTTACATCATTGTAATTATTACTGGTATTTACAATTTGCAAGA
GTTTTGGGTTAGTTTTTTTTTTTTTTTTTGCTTTGTTTTTGTACAAAAGAGTCTAACATTTTTTGCCAAACAGATATATATTTAATGAAA
AGAAGAGATACATAAATGTGTGAATTTCCAGTTTTTTTTTAATTATTTTAATCCCAAACATCTTCCTGAAAATAACATTCCCTTAAACAT

>5107_5107_4_AOAH-ELMO1_AOAH_chr7_36698771_ENST00000258749_ELMO1_chr7_36934622_ENST00000341056_length(amino acids)=378AA_BP=130
MQSPWKILTVAPLFLLLSLQSSASPANDDQSRPSLSNGHTCVGCVLVVSVIEQLAQVHNSTVQASMERLCSYLPEKLFLKTTCYLVIDKF
GSDIIKLLSADMNADVVCHTLEFCKQNTGQPLCHLYPLPKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQ
SRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTG
KDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDA

--------------------------------------------------------------
>5107_5107_5_AOAH-ELMO1_AOAH_chr7_36698771_ENST00000431169_ELMO1_chr7_36934622_ENST00000341056_length(transcript)=2633nt_BP=691nt
TTTCTTTATCCTGCAGTCTTTACCTCAGCAGAACCGCACACCACAGACTCCCTCCAGCTCTTTGTGTGTGGCTCTCTCAGGGTCCAACAA
GAGCAAGCTGTGGGTCTGTGAGTGTTTATGTGTGCTTTTATTCACTTCACACTTATTGAAAAGTGTGTATGTGAGAGGGTGGGGTGTGTG
TGTCAAAGAGAGTGAGGAAGAGAAGGAGAGAGAGATCAATTGATTCTGCAGCCTCAGCTCCAGCATCCCTCAGTTGGGAGCTTCCAAAGC
CGGGTGATCACTTGGGGTGCATAGCTCGGAGATGCAGTCCCCCTGGAAAATCCTTACGGTGGCGCCTCTATTCTTGCTCCTGTCTCTTCA
GTCCTCGGCCTCTCCAGCCAACGATGACCAGTCCAGGCCCAGCCTCTCGAATGGGCACACCTGTGTAGGGTGTGTGCTGGTGGTGTCTGT
AATAGAACAGCTTGCTCAAGTTCACAACTCGACGGTCCAGGCCTCGATGGAGAGACTGTGCAGCTACCTGCCTGAAAAACTGTTCTTGAA
AACCACCTGCTATTTAGTCATTGACAAGTTTGGATCAGACATCATAAAACTGCTTAGCGCAGATATGAATGCTGATGTGGTATGTCACAC
TCTGGAGTTTTGTAAACAGAACACTGGCCAACCATTGTGTCATCTCTACCCTCTTCCCAAGGTAATGCAGGTGGTGAAGGAGCAGGTTAT
GAGAGCACTTACAACCAAGCCTAGCTCCCTGGACCAGTTCAAGAGCAAACTGCAGAACCTGAGCTACACTGAGATCCTGAAAATCCGCCA
GTCCGAGAGGATGAACCAGGAAGATTTCCAGTCCCGCCCGATTTTGGAACTAAAGGAGAAGATTCAGCCAGAAATCTTAGAGCTGATCAA
ACAGCAACGCCTGAACCGCCTTGTGGAAGGGACCTGCTTTAGGAAACTCAATGCCCGGCGGAGGCAAGACAAGTTTTGGTATTGTCGGCT
TTCGCCAAATCACAAAGTCCTGCATTACGGAGACTTAGAAGAGAGTCCTCAGGGAGAAGTGCCCCACGATTCCTTGCAGGACAAACTGCC
GGTGGCAGATATCAAAGCCGTGGTGACGGGAAAGGACTGCCCTCATATGAAAGAGAAAGGTGCCCTTAAACAAAACAAGGAGGTGCTTGA
ACTCGCTTTCTCCATCTTGTATGACTCAAACTGCCAACTGAACTTCATCGCTCCTGACAAGCATGAGTACTGTATCTGGACGGATGGACT
GAATGCGCTACTCGGGAAGGACATGATGAGCGACCTGACGCGGAATGACCTGGACACCCTGCTCAGCATGGAAATCAAGCTCCGCCTCCT
GGACCTGGAAAACATCCAGATCCCTGACGCACCTCCGCCGATTCCCAAGGAGCCCAGCAACTATGACTTCGTCTATGACTGTAACTGAAG
TGGCCGGGCCCAGACATGCCCCTTCCAAAACTGGAACACCTAGCTAACAGGAGAGAGGAATGAAAACACACCCACGCCTTGGAACCGTCC
TTTGGTAAAGGGAAGCTGTGGGTCCACATTCCCTTCAGCATCACCTCTAGCCCTGGCAACTTTCAGCCCCTAGCTGGCATCTTGCTCACC
GCCCTGATTCTGTTCCTCGGCTCCACTGCTTCAGGTCACTTCCCATGGCTGCAGTCCACTGGTGGGACAAGAGCAAAGCCCACTGCCAGT
AAGAAGGCCAAAGGGCCCTTCCATCCTAGCCCTCTGCAGGCATGCCCTTCCTTCCCTTGGGCAGGAAAGCCAGCAGCCCCAGACTGCCCA
AAAACTTGCCCACCAGACCAAGGGCAGTGCCCCAAGGCCCCTGTCTGGAGGAAATGGCCTAGCTATTTGATGAGAAGACCAAACCCCACA
TCCTCCTTTCCCCTCTCTCTAGAATCATCTCGCACCACCAGTTACACTTGAATTAAGATCTGCGCTCAAATCTCCTCCCACCTCTCTCCC
TGCTTTTGCCTTGCTCTGTTCCTCTTTGGTCCCAAGAGCAGCAGCCGCAGCCTCCTCGTGATCCTCCCTAGCATAAATTTCCCAAACAGT
CCACAGGTCCCATGCCCACTTTGCGTCTGCACTGTGATCGTGACAAATCTTCCCTCCTCACCAGCTAGTCTGGGGTTTCCTCTCCCTGCC
CCAGGCCAGAACTGCCTTCTTCATTTCCACCCACGCTCCCAGCCTCTTAGCTGAAAGCACAAATGGTGAAATCAGTAGTCTCGCTCCATC
TCTAATAGACTAAACCTAAATGCCTCTAGGACGGACTGTTGCTATCCAAGCGTTTGGTGTTACCTTCTCCTGGGAGGTCCTGCTGCAACT
CAAGTTCCACAGGATGGTCAAGCTGTCAGACATCCAAGTTTACATCATTGTAATTATTACTGGTATTTACAATTTGCAAGAGTTTTGGGT
TAGTTTTTTTTTTTTTTTTTGCTTTGTTTTTGTACAAAAGAGTCTAACATTTTTTGCCAAACAGATATATATTTAATGAAAAGAAGAGAT
ACATAAATGTGTGAATTTCCAGTTTTTTTTTAATTATTTTAATCCCAAACATCTTCCTGAAAATAACATTCCCTTAAACATGCTGTGGAA

>5107_5107_5_AOAH-ELMO1_AOAH_chr7_36698771_ENST00000431169_ELMO1_chr7_36934622_ENST00000341056_length(amino acids)=378AA_BP=130
MQSPWKILTVAPLFLLLSLQSSASPANDDQSRPSLSNGHTCVGCVLVVSVIEQLAQVHNSTVQASMERLCSYLPEKLFLKTTCYLVIDKF
GSDIIKLLSADMNADVVCHTLEFCKQNTGQPLCHLYPLPKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQ
SRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTG
KDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDA

--------------------------------------------------------------
>5107_5107_6_AOAH-ELMO1_AOAH_chr7_36698771_ENST00000535891_ELMO1_chr7_36934622_ENST00000341056_length(transcript)=2637nt_BP=695nt
AACAGATCAGTTCCGGCAAGCCTCGAGGCTCACGGGGTTTATGCACACTAACTTCACTGAGCCAGGGAGCACGGAAGTTGTGCCACTGTG
CAACTTGGGTTTTCTTTATCCTGCAGTCTTTACCTCAGCAGAACCGCACACCACAGACTCCCTCCAGCTCTTTGTGTGTGGCTCTCTCAG
GGTCCAACAAGAGCAAGCTGTGGGTCTGTGAGTGTTTATGTGTGCTTTTATTCACTTCACACTTATTGAAAAGTGTGTATGTGAGAGGGT
GGGGTGTGTGTGTCAAAGAGAGTGAGGAAGAGAAGGAGAGAGAGATCAATTGATTCTGCAGCCTCAGCTCCAGCATCCCTCAGTTGGGAG
CTTCCAAAGCCGGGTGATCACTTGGGGTGCATAGCTCGGAGATGCAGTCCCCCTGGAAAATCCTTACGGTGGCGCCTCTATTCTTGCTCC
TGTCTCTTCAGTCCTCGGCCTCTCCAGCCAACGATGACCAGTCCAGGCCCAGCCTCTCGAATGGGCACACCTGTGTAGAAAAACTGTTCT
TGAAAACCACCTGCTATTTAGTCATTGACAAGTTTGGATCAGACATCATAAAACTGCTTAGCGCAGATATGAATGCTGATGTGGTATGTC
ACACTCTGGAGTTTTGTAAACAGAACACTGGCCAACCATTGTGTCATCTCTACCCTCTTCCCAAGGTAATGCAGGTGGTGAAGGAGCAGG
TTATGAGAGCACTTACAACCAAGCCTAGCTCCCTGGACCAGTTCAAGAGCAAACTGCAGAACCTGAGCTACACTGAGATCCTGAAAATCC
GCCAGTCCGAGAGGATGAACCAGGAAGATTTCCAGTCCCGCCCGATTTTGGAACTAAAGGAGAAGATTCAGCCAGAAATCTTAGAGCTGA
TCAAACAGCAACGCCTGAACCGCCTTGTGGAAGGGACCTGCTTTAGGAAACTCAATGCCCGGCGGAGGCAAGACAAGTTTTGGTATTGTC
GGCTTTCGCCAAATCACAAAGTCCTGCATTACGGAGACTTAGAAGAGAGTCCTCAGGGAGAAGTGCCCCACGATTCCTTGCAGGACAAAC
TGCCGGTGGCAGATATCAAAGCCGTGGTGACGGGAAAGGACTGCCCTCATATGAAAGAGAAAGGTGCCCTTAAACAAAACAAGGAGGTGC
TTGAACTCGCTTTCTCCATCTTGTATGACTCAAACTGCCAACTGAACTTCATCGCTCCTGACAAGCATGAGTACTGTATCTGGACGGATG
GACTGAATGCGCTACTCGGGAAGGACATGATGAGCGACCTGACGCGGAATGACCTGGACACCCTGCTCAGCATGGAAATCAAGCTCCGCC
TCCTGGACCTGGAAAACATCCAGATCCCTGACGCACCTCCGCCGATTCCCAAGGAGCCCAGCAACTATGACTTCGTCTATGACTGTAACT
GAAGTGGCCGGGCCCAGACATGCCCCTTCCAAAACTGGAACACCTAGCTAACAGGAGAGAGGAATGAAAACACACCCACGCCTTGGAACC
GTCCTTTGGTAAAGGGAAGCTGTGGGTCCACATTCCCTTCAGCATCACCTCTAGCCCTGGCAACTTTCAGCCCCTAGCTGGCATCTTGCT
CACCGCCCTGATTCTGTTCCTCGGCTCCACTGCTTCAGGTCACTTCCCATGGCTGCAGTCCACTGGTGGGACAAGAGCAAAGCCCACTGC
CAGTAAGAAGGCCAAAGGGCCCTTCCATCCTAGCCCTCTGCAGGCATGCCCTTCCTTCCCTTGGGCAGGAAAGCCAGCAGCCCCAGACTG
CCCAAAAACTTGCCCACCAGACCAAGGGCAGTGCCCCAAGGCCCCTGTCTGGAGGAAATGGCCTAGCTATTTGATGAGAAGACCAAACCC
CACATCCTCCTTTCCCCTCTCTCTAGAATCATCTCGCACCACCAGTTACACTTGAATTAAGATCTGCGCTCAAATCTCCTCCCACCTCTC
TCCCTGCTTTTGCCTTGCTCTGTTCCTCTTTGGTCCCAAGAGCAGCAGCCGCAGCCTCCTCGTGATCCTCCCTAGCATAAATTTCCCAAA
CAGTCCACAGGTCCCATGCCCACTTTGCGTCTGCACTGTGATCGTGACAAATCTTCCCTCCTCACCAGCTAGTCTGGGGTTTCCTCTCCC
TGCCCCAGGCCAGAACTGCCTTCTTCATTTCCACCCACGCTCCCAGCCTCTTAGCTGAAAGCACAAATGGTGAAATCAGTAGTCTCGCTC
CATCTCTAATAGACTAAACCTAAATGCCTCTAGGACGGACTGTTGCTATCCAAGCGTTTGGTGTTACCTTCTCCTGGGAGGTCCTGCTGC
AACTCAAGTTCCACAGGATGGTCAAGCTGTCAGACATCCAAGTTTACATCATTGTAATTATTACTGGTATTTACAATTTGCAAGAGTTTT
GGGTTAGTTTTTTTTTTTTTTTTTGCTTTGTTTTTGTACAAAAGAGTCTAACATTTTTTGCCAAACAGATATATATTTAATGAAAAGAAG
AGATACATAAATGTGTGAATTTCCAGTTTTTTTTTAATTATTTTAATCCCAAACATCTTCCTGAAAATAACATTCCCTTAAACATGCTGT

>5107_5107_6_AOAH-ELMO1_AOAH_chr7_36698771_ENST00000535891_ELMO1_chr7_36934622_ENST00000341056_length(amino acids)=346AA_BP=98
MQSPWKILTVAPLFLLLSLQSSASPANDDQSRPSLSNGHTCVEKLFLKTTCYLVIDKFGSDIIKLLSADMNADVVCHTLEFCKQNTGQPL
CHLYPLPKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRPILELKEKIQPEILELIKQQRLNRLVEGTC
FRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQ

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Fusion Gene PPI Analysis for AOAH-ELMO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AOAH-ELMO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AOAH-ELMO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAOAHC0236733Amphetamine-Related Disorders1CTD_human
HgeneAOAHC0236804Amphetamine Addiction1CTD_human
HgeneAOAHC0236807Amphetamine Abuse1CTD_human
TgeneC0011881Diabetic Nephropathy1CTD_human
TgeneC0014518Toxic Epidermal Necrolysis1CTD_human
TgeneC0017667Nodular glomerulosclerosis1CTD_human
TgeneC0038325Stevens-Johnson Syndrome1CTD_human
TgeneC0279628Adenocarcinoma Of Esophagus1CTD_human
TgeneC1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
TgeneC3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
TgeneC3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human