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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HNRNPH3-SLC29A3 (FusionGDB2 ID:HG3189TG55315)

Fusion Gene Summary for HNRNPH3-SLC29A3

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPH3-SLC29A3
Fusion gene ID: hg3189tg55315
HgeneTgene
Gene symbol

HNRNPH3

SLC29A3

Gene ID

3189

55315

Gene nameheterogeneous nuclear ribonucleoprotein H3solute carrier family 29 member 3
Synonyms2H9|HNRPH3ENT3|HCLAP|HJCD|PHID
Cytomap('HNRNPH3')('SLC29A3')

10q21.3

10q22.1

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein H3heterogeneous nuclear ribonucleoprotein 2H9hnRNP 2H9hnRNP H3equilibrative nucleoside transporter 3solute carrier family 29 (equilibrative nucleoside transporter), member 3solute carrier family 29 (nucleoside transporters), member 3
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000469172, ENST00000265866, 
ENST00000354695, ENST00000441000, 
Fusion gene scores* DoF score9 X 7 X 6=3783 X 3 X 3=27
# samples 105
** MAII scorelog2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/27*10)=0.888968687611256
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HNRNPH3 [Title/Abstract] AND SLC29A3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHNRNPH3(70099312)-SLC29A3(73121711), # samples:3
Anticipated loss of major functional domain due to fusion event.HNRNPH3-SLC29A3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPH3-SLC29A3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPH3-SLC29A3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPH3-SLC29A3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HNRNPH3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SLC29A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-8631-01AHNRNPH3chr10

70099312

-SLC29A3chr10

73121711

+
ChimerDB4STADTCGA-FP-8631-01AHNRNPH3chr10

70099312

+SLC29A3chr10

73121711

+
ChimerDB4STADTCGA-FP-8631HNRNPH3chr10

70099312

+SLC29A3chr10

73121710

+


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Fusion Gene ORF analysis for HNRNPH3-SLC29A3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000469172ENST00000373189HNRNPH3chr10

70099312

+SLC29A3chr10

73121711

+
3UTR-3CDSENST00000469172ENST00000373189HNRNPH3chr10

70099312

+SLC29A3chr10

73121710

+
3UTR-3UTRENST00000469172ENST00000469204HNRNPH3chr10

70099312

+SLC29A3chr10

73121711

+
3UTR-3UTRENST00000469172ENST00000469204HNRNPH3chr10

70099312

+SLC29A3chr10

73121710

+
5CDS-3UTRENST00000265866ENST00000469204HNRNPH3chr10

70099312

+SLC29A3chr10

73121711

+
5CDS-3UTRENST00000265866ENST00000469204HNRNPH3chr10

70099312

+SLC29A3chr10

73121710

+
5CDS-3UTRENST00000354695ENST00000469204HNRNPH3chr10

70099312

+SLC29A3chr10

73121711

+
5CDS-3UTRENST00000354695ENST00000469204HNRNPH3chr10

70099312

+SLC29A3chr10

73121710

+
5CDS-3UTRENST00000441000ENST00000469204HNRNPH3chr10

70099312

+SLC29A3chr10

73121711

+
5CDS-3UTRENST00000441000ENST00000469204HNRNPH3chr10

70099312

+SLC29A3chr10

73121710

+
In-frameENST00000265866ENST00000373189HNRNPH3chr10

70099312

+SLC29A3chr10

73121711

+
In-frameENST00000265866ENST00000373189HNRNPH3chr10

70099312

+SLC29A3chr10

73121710

+
In-frameENST00000354695ENST00000373189HNRNPH3chr10

70099312

+SLC29A3chr10

73121711

+
In-frameENST00000354695ENST00000373189HNRNPH3chr10

70099312

+SLC29A3chr10

73121710

+
In-frameENST00000441000ENST00000373189HNRNPH3chr10

70099312

+SLC29A3chr10

73121711

+
In-frameENST00000441000ENST00000373189HNRNPH3chr10

70099312

+SLC29A3chr10

73121710

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000265866HNRNPH3chr1070099312+ENST00000373189SLC29A3chr1073121711+2236804165848227
ENST00000441000HNRNPH3chr1070099312+ENST00000373189SLC29A3chr1073121711+18914594391113224
ENST00000354695HNRNPH3chr1070099312+ENST00000373189SLC29A3chr1073121711+21447126921366224
ENST00000265866HNRNPH3chr1070099312+ENST00000373189SLC29A3chr1073121710+2236804165848227
ENST00000441000HNRNPH3chr1070099312+ENST00000373189SLC29A3chr1073121710+18914594391113224
ENST00000354695HNRNPH3chr1070099312+ENST00000373189SLC29A3chr1073121710+21447126921366224

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265866ENST00000373189HNRNPH3chr1070099312+SLC29A3chr1073121711+0.0022050060.997795
ENST00000441000ENST00000373189HNRNPH3chr1070099312+SLC29A3chr1073121711+0.0612227620.9387772
ENST00000354695ENST00000373189HNRNPH3chr1070099312+SLC29A3chr1073121711+0.045024060.95497596
ENST00000265866ENST00000373189HNRNPH3chr1070099312+SLC29A3chr1073121710+0.0022050060.997795
ENST00000441000ENST00000373189HNRNPH3chr1070099312+SLC29A3chr1073121710+0.0612227620.9387772
ENST00000354695ENST00000373189HNRNPH3chr1070099312+SLC29A3chr1073121710+0.045024060.95497596

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Fusion Genomic Features for HNRNPH3-SLC29A3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HNRNPH3chr1070099312+SLC29A3chr1073121710+1.79E-070.99999976
HNRNPH3chr1070099312+SLC29A3chr1073121710+1.79E-070.99999976
HNRNPH3chr1070099312+SLC29A3chr1073121710+1.79E-070.99999976
HNRNPH3chr1070099312+SLC29A3chr1073121710+1.79E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HNRNPH3-SLC29A3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:70099312/chr10:73121711)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPH3chr10:70099312chr10:73121710ENST00000265866+61016_93213347.0DomainRRM 1
HgeneHNRNPH3chr10:70099312chr10:73121710ENST00000354695+61016_93198332.0DomainRRM 1
HgeneHNRNPH3chr10:70099312chr10:73121711ENST00000265866+61016_93213347.0DomainRRM 1
HgeneHNRNPH3chr10:70099312chr10:73121711ENST00000354695+61016_93198332.0DomainRRM 1
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946327_337257476.0Topological domainExtracellular
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946359_377257476.0Topological domainCytoplasmic
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946399_415257476.0Topological domainExtracellular
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946437_454257476.0Topological domainCytoplasmic
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946327_337257476.0Topological domainExtracellular
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946359_377257476.0Topological domainCytoplasmic
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946399_415257476.0Topological domainExtracellular
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946437_454257476.0Topological domainCytoplasmic
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946306_326257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946338_358257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946378_398257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946416_436257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946455_475257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946306_326257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946338_358257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946378_398257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946416_436257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946455_475257476.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPH3chr10:70099312chr10:73121710ENST00000265866+610108_344213347.0Compositional biasNote=Gly-rich
HgeneHNRNPH3chr10:70099312chr10:73121710ENST00000354695+610108_344198332.0Compositional biasNote=Gly-rich
HgeneHNRNPH3chr10:70099312chr10:73121711ENST00000265866+610108_344213347.0Compositional biasNote=Gly-rich
HgeneHNRNPH3chr10:70099312chr10:73121711ENST00000354695+610108_344198332.0Compositional biasNote=Gly-rich
HgeneHNRNPH3chr10:70099312chr10:73121710ENST00000265866+610195_270213347.0DomainRRM 2
HgeneHNRNPH3chr10:70099312chr10:73121710ENST00000354695+610195_270198332.0DomainRRM 2
HgeneHNRNPH3chr10:70099312chr10:73121711ENST00000265866+610195_270213347.0DomainRRM 2
HgeneHNRNPH3chr10:70099312chr10:73121711ENST00000354695+610195_270198332.0DomainRRM 2
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946127_134257476.0Topological domainCytoplasmic
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946156_162257476.0Topological domainExtracellular
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946184_199257476.0Topological domainCytoplasmic
TgeneSLC29A3chr10:70099312chr10:73121710ENST00000373189461_53257476.0Topological domainCytoplasmic
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946221_230257476.0Topological domainExtracellular
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946252_305257476.0Topological domainCytoplasmic
TgeneSLC29A3chr10:70099312chr10:73121710ENST000003731894675_105257476.0Topological domainExtracellular
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946127_134257476.0Topological domainCytoplasmic
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946156_162257476.0Topological domainExtracellular
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946184_199257476.0Topological domainCytoplasmic
TgeneSLC29A3chr10:70099312chr10:73121711ENST00000373189461_53257476.0Topological domainCytoplasmic
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946221_230257476.0Topological domainExtracellular
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946252_305257476.0Topological domainCytoplasmic
TgeneSLC29A3chr10:70099312chr10:73121711ENST000003731894675_105257476.0Topological domainExtracellular
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946106_126257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946135_155257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946163_183257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946200_220257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121710ENST0000037318946231_251257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121710ENST000003731894654_74257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946106_126257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946135_155257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946163_183257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946200_220257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121711ENST0000037318946231_251257476.0TransmembraneHelical
TgeneSLC29A3chr10:70099312chr10:73121711ENST000003731894654_74257476.0TransmembraneHelical


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Fusion Gene Sequence for HNRNPH3-SLC29A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37218_37218_1_HNRNPH3-SLC29A3_HNRNPH3_chr10_70099312_ENST00000265866_SLC29A3_chr10_73121710_ENST00000373189_length(transcript)=2236nt_BP=804nt
TGCGCAGCTCCCTAAGCGGTTGTCACCGCTGGAGACGGTTGGGAGAACCGTTGTGGCGAGCGCTACACGAGGCAAACGACTTCTCCCTTC
TTTGAACTGGACCCCGCGAGCACCAGAGTCGGCGTAACTATCGCCTGACAGGCATTTAAATCAAACGGTATTGAGATGGATTGGGTTATG
AAACATAATGGTCCAAATGACGCTAGTGATGGGACAGTACGACTTCGTGGACTACCATTTGGTTGCAGCAAAGAGGAAATAGTTCAGTTC
TTTCAAGGGTTGGAAATCGTGCCAAATGGGATAACATTGACGATGGACTACCAGGGGAGAAGCACAGGGGAGGCCTTCGTGCAGTTTGCT
TCAAAGGAGATAGCAGAAAATGCTCTGGGGAAACACAAGGAAAGAATAGGGCACAGGTATATTGAGATCTTCAGAAGTAGCAGGAGTGAA
ATCAAAGGATTTTATGATCCACCAAGAAGATTGCTGGGACAGCGACCGGGACCATATGATAGACCAATAGGAGGAAGAGGGGGTTATTAT
GGAGCTGGGCGTGGAAGTATGTATGACAGAATGCGACGAGGAGGTGATGGATATGATGGTGGTTATGGAGGTTTTGATGACTATGGTGGC
TATAATAATTACGGCTATGGGAATGATGGCTTTGATGACAGAATGAGAGATGGAAGAGGTATGGGAGGACATGGCTATGGTGGAGCTGGT
GATGCAAGTTCAGGTTTTCATGGTGGTCATTTCGTACATATGAGAGGGTTGCCTTTTCGTGCAACTGAAAATGACATTGCTAATGTACTA
CATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCCCTCAGTGCCCCTTCGGTGGCCTCCAGATT
CATTGATTCCCACACACCCCCTCTCCGCCCCATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAG
CCTCATCTACCCCGCCATCTGCACCAACATCGAGTCCCTCAACAAGGGTTCGGGCTCACTGTGGACCACCAAGTTTTTCATCCCCCTCAC
TACCTTCCTCCTGTACAACTTTGCTGACCTATGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCC
AGGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCCCGCGTCCACCTGAAGACTGTGGTCTTCCA
GTCCGATGTGTACCCCGCACTCCTCAGCTCCCTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGAT
TGTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGCTTAACACTGGGCTCAGCCTGCTCTACCCT
CCTGGTGCACCTCATCTAGAAGGGAGGACACAAGGACATTGGTGCTTCAGAGCCTTTGAAGATGAGAAGAGAGTGCAGGAGGGCTGGGGG
CCATGGAGGAAAGGCCTAAAGTTTCACTTGGGGACAGAGAGCAGAGCACACTCGGGCCTCATCCCTCCCAAGATGCCAGTGAGCCACGTC
CATGCCCATTCCGTGCAAGGCAGATATTCCAGTCATATTAACAGAACACTCCTGAGACAGTTGAAGAAGAAATAGCACAAATCAGGGGTA
CTCCCTTCACAGCTGATGGTTAACATTCCACCTTCTTTCTAGCCCTTCAAAGATGCTGCCAGTGTTCGCCCTAGAGTTATTACAAAGCCA
GTGCCAAAACCCAGCCATGGGCTCTTTGCAACCTCCCAGCTGCGCTCATTCCAGCTGACAGCGAGATGCAAGCAAATGCTCAGCTCTCCT
TACCCTGAAGGGGTCTCCCTGGAATGGAAGTCCCCTGGCATGGTCAGTCCTCAGGCCCAAGACTCAAGTGTGCACAGACCCCTGTGTTCT
GTGGGTGAACAACTGCCCACTAACCAGACTGGAAAACCCAGAAAGATGGGCCTTCCATGAATGCTTCATTCCAGAGGGACCAGAGGGCCT
CCCTGTGCAAGGGATCAAGCATGTCTGGCCTGGGTTTTCAAAAAAAGAGGGATCCTCATGACCTGGTGGTCTATGGCCTGGGTCAAGATG

>37218_37218_1_HNRNPH3-SLC29A3_HNRNPH3_chr10_70099312_ENST00000265866_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=227AA_BP=
MDWVMKHNGPNDASDGTVRLRGLPFGCSKEEIVQFFQGLEIVPNGITLTMDYQGRSTGEAFVQFASKEIAENALGKHKERIGHRYIEIFR
SSRSEIKGFYDPPRRLLGQRPGPYDRPIGGRGGYYGAGRGSMYDRMRRGGDGYDGGYGGFDDYGGYNNYGYGNDGFDDRMRDGRGMGGHG

--------------------------------------------------------------
>37218_37218_2_HNRNPH3-SLC29A3_HNRNPH3_chr10_70099312_ENST00000265866_SLC29A3_chr10_73121711_ENST00000373189_length(transcript)=2236nt_BP=804nt
TGCGCAGCTCCCTAAGCGGTTGTCACCGCTGGAGACGGTTGGGAGAACCGTTGTGGCGAGCGCTACACGAGGCAAACGACTTCTCCCTTC
TTTGAACTGGACCCCGCGAGCACCAGAGTCGGCGTAACTATCGCCTGACAGGCATTTAAATCAAACGGTATTGAGATGGATTGGGTTATG
AAACATAATGGTCCAAATGACGCTAGTGATGGGACAGTACGACTTCGTGGACTACCATTTGGTTGCAGCAAAGAGGAAATAGTTCAGTTC
TTTCAAGGGTTGGAAATCGTGCCAAATGGGATAACATTGACGATGGACTACCAGGGGAGAAGCACAGGGGAGGCCTTCGTGCAGTTTGCT
TCAAAGGAGATAGCAGAAAATGCTCTGGGGAAACACAAGGAAAGAATAGGGCACAGGTATATTGAGATCTTCAGAAGTAGCAGGAGTGAA
ATCAAAGGATTTTATGATCCACCAAGAAGATTGCTGGGACAGCGACCGGGACCATATGATAGACCAATAGGAGGAAGAGGGGGTTATTAT
GGAGCTGGGCGTGGAAGTATGTATGACAGAATGCGACGAGGAGGTGATGGATATGATGGTGGTTATGGAGGTTTTGATGACTATGGTGGC
TATAATAATTACGGCTATGGGAATGATGGCTTTGATGACAGAATGAGAGATGGAAGAGGTATGGGAGGACATGGCTATGGTGGAGCTGGT
GATGCAAGTTCAGGTTTTCATGGTGGTCATTTCGTACATATGAGAGGGTTGCCTTTTCGTGCAACTGAAAATGACATTGCTAATGTACTA
CATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCCCTCAGTGCCCCTTCGGTGGCCTCCAGATT
CATTGATTCCCACACACCCCCTCTCCGCCCCATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAG
CCTCATCTACCCCGCCATCTGCACCAACATCGAGTCCCTCAACAAGGGTTCGGGCTCACTGTGGACCACCAAGTTTTTCATCCCCCTCAC
TACCTTCCTCCTGTACAACTTTGCTGACCTATGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCC
AGGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCCCGCGTCCACCTGAAGACTGTGGTCTTCCA
GTCCGATGTGTACCCCGCACTCCTCAGCTCCCTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGAT
TGTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGCTTAACACTGGGCTCAGCCTGCTCTACCCT
CCTGGTGCACCTCATCTAGAAGGGAGGACACAAGGACATTGGTGCTTCAGAGCCTTTGAAGATGAGAAGAGAGTGCAGGAGGGCTGGGGG
CCATGGAGGAAAGGCCTAAAGTTTCACTTGGGGACAGAGAGCAGAGCACACTCGGGCCTCATCCCTCCCAAGATGCCAGTGAGCCACGTC
CATGCCCATTCCGTGCAAGGCAGATATTCCAGTCATATTAACAGAACACTCCTGAGACAGTTGAAGAAGAAATAGCACAAATCAGGGGTA
CTCCCTTCACAGCTGATGGTTAACATTCCACCTTCTTTCTAGCCCTTCAAAGATGCTGCCAGTGTTCGCCCTAGAGTTATTACAAAGCCA
GTGCCAAAACCCAGCCATGGGCTCTTTGCAACCTCCCAGCTGCGCTCATTCCAGCTGACAGCGAGATGCAAGCAAATGCTCAGCTCTCCT
TACCCTGAAGGGGTCTCCCTGGAATGGAAGTCCCCTGGCATGGTCAGTCCTCAGGCCCAAGACTCAAGTGTGCACAGACCCCTGTGTTCT
GTGGGTGAACAACTGCCCACTAACCAGACTGGAAAACCCAGAAAGATGGGCCTTCCATGAATGCTTCATTCCAGAGGGACCAGAGGGCCT
CCCTGTGCAAGGGATCAAGCATGTCTGGCCTGGGTTTTCAAAAAAAGAGGGATCCTCATGACCTGGTGGTCTATGGCCTGGGTCAAGATG

>37218_37218_2_HNRNPH3-SLC29A3_HNRNPH3_chr10_70099312_ENST00000265866_SLC29A3_chr10_73121711_ENST00000373189_length(amino acids)=227AA_BP=
MDWVMKHNGPNDASDGTVRLRGLPFGCSKEEIVQFFQGLEIVPNGITLTMDYQGRSTGEAFVQFASKEIAENALGKHKERIGHRYIEIFR
SSRSEIKGFYDPPRRLLGQRPGPYDRPIGGRGGYYGAGRGSMYDRMRRGGDGYDGGYGGFDDYGGYNNYGYGNDGFDDRMRDGRGMGGHG

--------------------------------------------------------------
>37218_37218_3_HNRNPH3-SLC29A3_HNRNPH3_chr10_70099312_ENST00000354695_SLC29A3_chr10_73121710_ENST00000373189_length(transcript)=2144nt_BP=712nt
CCGTTGTGGCGAGCGCTACACGAGGCAAACGACTTCTCCCTTCTTTGAACTGGACCCCGCGAGCACCAGAGTCGGCGTAACTATCGCCTG
ACAGGCATTTAAATCAAACGGTATTGAGATGGATTGGGTTATGAAACATAATGGTCCAAATGACGCTAGTGATGGGACAGTACGACTTCG
TGGACTACCATTTGGTTGCAGCAAAGAGGAAATAGTTCAGTTCTTTCAAGGGTTGGAAATCGTGCCAAATGGGATAACATTGACGATGGA
CTACCAGGGGAGAAGCACAGGGGAGGCCTTCGTGCAGTTTGCTTCAAAGGAGATAGCAGAAAATGCTCTGGGGAAACACAAGGAAAGAAT
AGGGCACAGGTATATTGAGATCTTCAGAAGTAGCAGGAGTGAAATCAAAGGATTTTATGATCCACCAAGAAGATTGCTGGGACAGCGACC
GGGACCATATGATAGACCAATAGGAGGAAGAGGGGGTTATTATGGAGCTGGGCGTGGAAGTTATGGAGGTTTTGATGACTATGGTGGCTA
TAATAATTACGGCTATGGGAATGATGGCTTTGATGACAGAATGAGAGATGGAAGAGGTATGGGAGGACATGGCTATGGTGGAGCTGGTGA
TGCAAGTTCAGGTTTTCATGGTGGTCATTTCGTACATATGAGAGGGTTGCCTTTTCGTGCAACTGAAAATGACATTGCTAATGTACTACA
TGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCCCTCAGTGCCCCTTCGGTGGCCTCCAGATTCA
TTGATTCCCACACACCCCCTCTCCGCCCCATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAGCC
TCATCTACCCCGCCATCTGCACCAACATCGAGTCCCTCAACAAGGGTTCGGGCTCACTGTGGACCACCAAGTTTTTCATCCCCCTCACTA
CCTTCCTCCTGTACAACTTTGCTGACCTATGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCCAG
GGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCCCGCGTCCACCTGAAGACTGTGGTCTTCCAGT
CCGATGTGTACCCCGCACTCCTCAGCTCCCTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGATTG
TGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGCTTAACACTGGGCTCAGCCTGCTCTACCCTCC
TGGTGCACCTCATCTAGAAGGGAGGACACAAGGACATTGGTGCTTCAGAGCCTTTGAAGATGAGAAGAGAGTGCAGGAGGGCTGGGGGCC
ATGGAGGAAAGGCCTAAAGTTTCACTTGGGGACAGAGAGCAGAGCACACTCGGGCCTCATCCCTCCCAAGATGCCAGTGAGCCACGTCCA
TGCCCATTCCGTGCAAGGCAGATATTCCAGTCATATTAACAGAACACTCCTGAGACAGTTGAAGAAGAAATAGCACAAATCAGGGGTACT
CCCTTCACAGCTGATGGTTAACATTCCACCTTCTTTCTAGCCCTTCAAAGATGCTGCCAGTGTTCGCCCTAGAGTTATTACAAAGCCAGT
GCCAAAACCCAGCCATGGGCTCTTTGCAACCTCCCAGCTGCGCTCATTCCAGCTGACAGCGAGATGCAAGCAAATGCTCAGCTCTCCTTA
CCCTGAAGGGGTCTCCCTGGAATGGAAGTCCCCTGGCATGGTCAGTCCTCAGGCCCAAGACTCAAGTGTGCACAGACCCCTGTGTTCTGT
GGGTGAACAACTGCCCACTAACCAGACTGGAAAACCCAGAAAGATGGGCCTTCCATGAATGCTTCATTCCAGAGGGACCAGAGGGCCTCC
CTGTGCAAGGGATCAAGCATGTCTGGCCTGGGTTTTCAAAAAAAGAGGGATCCTCATGACCTGGTGGTCTATGGCCTGGGTCAAGATGAG

>37218_37218_3_HNRNPH3-SLC29A3_HNRNPH3_chr10_70099312_ENST00000354695_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=224AA_BP=7
MKMTLLMYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRPILKKTASLGFCVTYVFFITSLIYPAICTNIESLNKGSGSLW
TTKFFIPLTTFLLYNFADLCGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSSLLGLSNGYLST

--------------------------------------------------------------
>37218_37218_4_HNRNPH3-SLC29A3_HNRNPH3_chr10_70099312_ENST00000354695_SLC29A3_chr10_73121711_ENST00000373189_length(transcript)=2144nt_BP=712nt
CCGTTGTGGCGAGCGCTACACGAGGCAAACGACTTCTCCCTTCTTTGAACTGGACCCCGCGAGCACCAGAGTCGGCGTAACTATCGCCTG
ACAGGCATTTAAATCAAACGGTATTGAGATGGATTGGGTTATGAAACATAATGGTCCAAATGACGCTAGTGATGGGACAGTACGACTTCG
TGGACTACCATTTGGTTGCAGCAAAGAGGAAATAGTTCAGTTCTTTCAAGGGTTGGAAATCGTGCCAAATGGGATAACATTGACGATGGA
CTACCAGGGGAGAAGCACAGGGGAGGCCTTCGTGCAGTTTGCTTCAAAGGAGATAGCAGAAAATGCTCTGGGGAAACACAAGGAAAGAAT
AGGGCACAGGTATATTGAGATCTTCAGAAGTAGCAGGAGTGAAATCAAAGGATTTTATGATCCACCAAGAAGATTGCTGGGACAGCGACC
GGGACCATATGATAGACCAATAGGAGGAAGAGGGGGTTATTATGGAGCTGGGCGTGGAAGTTATGGAGGTTTTGATGACTATGGTGGCTA
TAATAATTACGGCTATGGGAATGATGGCTTTGATGACAGAATGAGAGATGGAAGAGGTATGGGAGGACATGGCTATGGTGGAGCTGGTGA
TGCAAGTTCAGGTTTTCATGGTGGTCATTTCGTACATATGAGAGGGTTGCCTTTTCGTGCAACTGAAAATGACATTGCTAATGTACTACA
TGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCCCTCAGTGCCCCTTCGGTGGCCTCCAGATTCA
TTGATTCCCACACACCCCCTCTCCGCCCCATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAGCC
TCATCTACCCCGCCATCTGCACCAACATCGAGTCCCTCAACAAGGGTTCGGGCTCACTGTGGACCACCAAGTTTTTCATCCCCCTCACTA
CCTTCCTCCTGTACAACTTTGCTGACCTATGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCCAG
GGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCCCGCGTCCACCTGAAGACTGTGGTCTTCCAGT
CCGATGTGTACCCCGCACTCCTCAGCTCCCTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGATTG
TGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGCTTAACACTGGGCTCAGCCTGCTCTACCCTCC
TGGTGCACCTCATCTAGAAGGGAGGACACAAGGACATTGGTGCTTCAGAGCCTTTGAAGATGAGAAGAGAGTGCAGGAGGGCTGGGGGCC
ATGGAGGAAAGGCCTAAAGTTTCACTTGGGGACAGAGAGCAGAGCACACTCGGGCCTCATCCCTCCCAAGATGCCAGTGAGCCACGTCCA
TGCCCATTCCGTGCAAGGCAGATATTCCAGTCATATTAACAGAACACTCCTGAGACAGTTGAAGAAGAAATAGCACAAATCAGGGGTACT
CCCTTCACAGCTGATGGTTAACATTCCACCTTCTTTCTAGCCCTTCAAAGATGCTGCCAGTGTTCGCCCTAGAGTTATTACAAAGCCAGT
GCCAAAACCCAGCCATGGGCTCTTTGCAACCTCCCAGCTGCGCTCATTCCAGCTGACAGCGAGATGCAAGCAAATGCTCAGCTCTCCTTA
CCCTGAAGGGGTCTCCCTGGAATGGAAGTCCCCTGGCATGGTCAGTCCTCAGGCCCAAGACTCAAGTGTGCACAGACCCCTGTGTTCTGT
GGGTGAACAACTGCCCACTAACCAGACTGGAAAACCCAGAAAGATGGGCCTTCCATGAATGCTTCATTCCAGAGGGACCAGAGGGCCTCC
CTGTGCAAGGGATCAAGCATGTCTGGCCTGGGTTTTCAAAAAAAGAGGGATCCTCATGACCTGGTGGTCTATGGCCTGGGTCAAGATGAG

>37218_37218_4_HNRNPH3-SLC29A3_HNRNPH3_chr10_70099312_ENST00000354695_SLC29A3_chr10_73121711_ENST00000373189_length(amino acids)=224AA_BP=7
MKMTLLMYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRPILKKTASLGFCVTYVFFITSLIYPAICTNIESLNKGSGSLW
TTKFFIPLTTFLLYNFADLCGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSSLLGLSNGYLST

--------------------------------------------------------------
>37218_37218_5_HNRNPH3-SLC29A3_HNRNPH3_chr10_70099312_ENST00000441000_SLC29A3_chr10_73121710_ENST00000373189_length(transcript)=1891nt_BP=459nt
GTCACCGCTGGAGACGGTTGGGAGAACCGTTGTGGCGAGCGCTACACGAGGCAAACGACTTCTCCCTTCTTTGAACTGGACCCCGCGAGC
ACCAGAGTCGGCGTAACTATCGCCTGACAGGCATTTAAATCAAACGGTATTGAGATGGATTGGGTTATGAAACATAATGGTCCAAATGAC
GCTAGTGATGGGACAGTACGACTTCGTGGACTACCATTTGGTTGCAGCAAAGAGGAAATAGTTCAGTTCTTTCAAGGTTATGGAGGTTTT
GATGACTATGGTGGCTATAATAATTACGGCTATGGGAATGATGGCTTTGATGACAGAATGAGAGATGGAAGAGGTATGGGAGGACATGGC
TATGGTGGAGCTGGTGATGCAAGTTCAGGTTTTCATGGTGGTCATTTCGTACATATGAGAGGGTTGCCTTTTCGTGCAACTGAAAATGAC
ATTGCTAATGTACTACATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCCCTCAGTGCCCCTTC
GGTGGCCTCCAGATTCATTGATTCCCACACACCCCCTCTCCGCCCCATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGT
CTTCTTCATCACCAGCCTCATCTACCCCGCCATCTGCACCAACATCGAGTCCCTCAACAAGGGTTCGGGCTCACTGTGGACCACCAAGTT
TTTCATCCCCCTCACTACCTTCCTCCTGTACAACTTTGCTGACCTATGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAA
TAGCAAGGCGCTCCCAGGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCCCGCGTCCACCTGAA
GACTGTGGTCTTCCAGTCCGATGTGTACCCCGCACTCCTCAGCTCCCTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCT
CTACGGGCCTAAGATTGTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGCTTAACACTGGGCTC
AGCCTGCTCTACCCTCCTGGTGCACCTCATCTAGAAGGGAGGACACAAGGACATTGGTGCTTCAGAGCCTTTGAAGATGAGAAGAGAGTG
CAGGAGGGCTGGGGGCCATGGAGGAAAGGCCTAAAGTTTCACTTGGGGACAGAGAGCAGAGCACACTCGGGCCTCATCCCTCCCAAGATG
CCAGTGAGCCACGTCCATGCCCATTCCGTGCAAGGCAGATATTCCAGTCATATTAACAGAACACTCCTGAGACAGTTGAAGAAGAAATAG
CACAAATCAGGGGTACTCCCTTCACAGCTGATGGTTAACATTCCACCTTCTTTCTAGCCCTTCAAAGATGCTGCCAGTGTTCGCCCTAGA
GTTATTACAAAGCCAGTGCCAAAACCCAGCCATGGGCTCTTTGCAACCTCCCAGCTGCGCTCATTCCAGCTGACAGCGAGATGCAAGCAA
ATGCTCAGCTCTCCTTACCCTGAAGGGGTCTCCCTGGAATGGAAGTCCCCTGGCATGGTCAGTCCTCAGGCCCAAGACTCAAGTGTGCAC
AGACCCCTGTGTTCTGTGGGTGAACAACTGCCCACTAACCAGACTGGAAAACCCAGAAAGATGGGCCTTCCATGAATGCTTCATTCCAGA
GGGACCAGAGGGCCTCCCTGTGCAAGGGATCAAGCATGTCTGGCCTGGGTTTTCAAAAAAAGAGGGATCCTCATGACCTGGTGGTCTATG
GCCTGGGTCAAGATGAGGGTCTTTCAGTGTTCCTGTTTACAACATGTCAAAGCCATTGGTTCAAGGGCGTAATAAATACTTGCGTATTCA

>37218_37218_5_HNRNPH3-SLC29A3_HNRNPH3_chr10_70099312_ENST00000441000_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=224AA_BP=7
MKMTLLMYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRPILKKTASLGFCVTYVFFITSLIYPAICTNIESLNKGSGSLW
TTKFFIPLTTFLLYNFADLCGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSSLLGLSNGYLST

--------------------------------------------------------------
>37218_37218_6_HNRNPH3-SLC29A3_HNRNPH3_chr10_70099312_ENST00000441000_SLC29A3_chr10_73121711_ENST00000373189_length(transcript)=1891nt_BP=459nt
GTCACCGCTGGAGACGGTTGGGAGAACCGTTGTGGCGAGCGCTACACGAGGCAAACGACTTCTCCCTTCTTTGAACTGGACCCCGCGAGC
ACCAGAGTCGGCGTAACTATCGCCTGACAGGCATTTAAATCAAACGGTATTGAGATGGATTGGGTTATGAAACATAATGGTCCAAATGAC
GCTAGTGATGGGACAGTACGACTTCGTGGACTACCATTTGGTTGCAGCAAAGAGGAAATAGTTCAGTTCTTTCAAGGTTATGGAGGTTTT
GATGACTATGGTGGCTATAATAATTACGGCTATGGGAATGATGGCTTTGATGACAGAATGAGAGATGGAAGAGGTATGGGAGGACATGGC
TATGGTGGAGCTGGTGATGCAAGTTCAGGTTTTCATGGTGGTCATTTCGTACATATGAGAGGGTTGCCTTTTCGTGCAACTGAAAATGAC
ATTGCTAATGTACTACATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCCCTCAGTGCCCCTTC
GGTGGCCTCCAGATTCATTGATTCCCACACACCCCCTCTCCGCCCCATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGT
CTTCTTCATCACCAGCCTCATCTACCCCGCCATCTGCACCAACATCGAGTCCCTCAACAAGGGTTCGGGCTCACTGTGGACCACCAAGTT
TTTCATCCCCCTCACTACCTTCCTCCTGTACAACTTTGCTGACCTATGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAA
TAGCAAGGCGCTCCCAGGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCCCGCGTCCACCTGAA
GACTGTGGTCTTCCAGTCCGATGTGTACCCCGCACTCCTCAGCTCCCTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCT
CTACGGGCCTAAGATTGTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGCTTAACACTGGGCTC
AGCCTGCTCTACCCTCCTGGTGCACCTCATCTAGAAGGGAGGACACAAGGACATTGGTGCTTCAGAGCCTTTGAAGATGAGAAGAGAGTG
CAGGAGGGCTGGGGGCCATGGAGGAAAGGCCTAAAGTTTCACTTGGGGACAGAGAGCAGAGCACACTCGGGCCTCATCCCTCCCAAGATG
CCAGTGAGCCACGTCCATGCCCATTCCGTGCAAGGCAGATATTCCAGTCATATTAACAGAACACTCCTGAGACAGTTGAAGAAGAAATAG
CACAAATCAGGGGTACTCCCTTCACAGCTGATGGTTAACATTCCACCTTCTTTCTAGCCCTTCAAAGATGCTGCCAGTGTTCGCCCTAGA
GTTATTACAAAGCCAGTGCCAAAACCCAGCCATGGGCTCTTTGCAACCTCCCAGCTGCGCTCATTCCAGCTGACAGCGAGATGCAAGCAA
ATGCTCAGCTCTCCTTACCCTGAAGGGGTCTCCCTGGAATGGAAGTCCCCTGGCATGGTCAGTCCTCAGGCCCAAGACTCAAGTGTGCAC
AGACCCCTGTGTTCTGTGGGTGAACAACTGCCCACTAACCAGACTGGAAAACCCAGAAAGATGGGCCTTCCATGAATGCTTCATTCCAGA
GGGACCAGAGGGCCTCCCTGTGCAAGGGATCAAGCATGTCTGGCCTGGGTTTTCAAAAAAAGAGGGATCCTCATGACCTGGTGGTCTATG
GCCTGGGTCAAGATGAGGGTCTTTCAGTGTTCCTGTTTACAACATGTCAAAGCCATTGGTTCAAGGGCGTAATAAATACTTGCGTATTCA

>37218_37218_6_HNRNPH3-SLC29A3_HNRNPH3_chr10_70099312_ENST00000441000_SLC29A3_chr10_73121711_ENST00000373189_length(amino acids)=224AA_BP=7
MKMTLLMYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRPILKKTASLGFCVTYVFFITSLIYPAICTNIESLNKGSGSLW
TTKFFIPLTTFLLYNFADLCGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSSLLGLSNGYLST

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HNRNPH3-SLC29A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HNRNPH3-SLC29A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HNRNPH3-SLC29A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1864445Histiocytosis with joint contractures and sensorineural deafness12CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0011854Diabetes Mellitus, Insulin-Dependent2CTD_human
TgeneC0020555Hypertrichosis2CTD_human
TgeneC0162834Hyperpigmentation2CTD_human
TgeneC0205734Diabetes, Autoimmune2CTD_human
TgeneC0342302Brittle diabetes2CTD_human
TgeneC3837958Diabetes Mellitus, Ketosis-Prone2CTD_human
TgeneC4554117Diabetes Mellitus, Sudden-Onset2CTD_human
TgeneC0011570Mental Depression1PSYGENET
TgeneC0011581Depressive disorder1PSYGENET
TgeneC0018798Congenital Heart Defects1CTD_human
TgeneC0019209Hepatomegaly1CTD_human
TgeneC0019618Histiocytosis1CTD_human
TgeneC0019625Sinus histiocytosis1CTD_human
TgeneC0020619Hypogonadism1CTD_human
TgeneC0271623Hypogonadotropic hypogonadism1CTD_human
TgeneC0948896Primary hypogonadism1CTD_human
TgeneC1384666hearing impairment1CTD_human
TgeneC3489396Hypogonadism, Isolated Hypogonadotropic1CTD_human
TgeneC3860213Autoinflammatory disorder1GENOMICS_ENGLAND