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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HNRNPL-RPS19BP1 (FusionGDB2 ID:HG3191TG91582)

Fusion Gene Summary for HNRNPL-RPS19BP1

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPL-RPS19BP1
Fusion gene ID: hg3191tg91582
HgeneTgene
Gene symbol

HNRNPL

RPS19BP1

Gene ID

3191

91582

Gene nameheterogeneous nuclear ribonucleoprotein Lribosomal protein S19 binding protein 1
SynonymsHNRPL|P/OKcl.14|hnRNP-LAROS|S19BP
Cytomap('HNRNPL')('RPS19BP1')

19q13.2

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein Lepididymis secretory sperm binding proteinhnRNP Lactive regulator of SIRT140S ribosomal protein S19-binding protein 1RPS19-binding protein 1homolog of mouse S19 binding protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000600873, ENST00000221419, 
Fusion gene scores* DoF score17 X 19 X 9=29071 X 2 X 1=2
# samples 191
** MAII scorelog2(19/2907*10)=-3.93545974780529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/2*10)=2.32192809488736
Context

PubMed: HNRNPL [Title/Abstract] AND RPS19BP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHNRNPL(39334482)-RPS19BP1(39925922), # samples:2
Anticipated loss of major functional domain due to fusion event.HNRNPL-RPS19BP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPL-RPS19BP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPL-RPS19BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPL-RPS19BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPL-RPS19BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HNRNPL-RPS19BP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HNRNPL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RPS19BP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2281-01AHNRNPLchr19

39332360

-RPS19BP1chr22

39925985

-
ChimerDB4OVTCGA-24-2281-01AHNRNPLchr19

39334482

-RPS19BP1chr22

39925922

-


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Fusion Gene ORF analysis for HNRNPL-RPS19BP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000600873ENST00000334678HNRNPLchr19

39334482

-RPS19BP1chr22

39925922

-
In-frameENST00000221419ENST00000334678HNRNPLchr19

39334482

-RPS19BP1chr22

39925922

-
intron-intronENST00000221419ENST00000334678HNRNPLchr19

39332360

-RPS19BP1chr22

39925985

-
intron-intronENST00000600873ENST00000334678HNRNPLchr19

39332360

-RPS19BP1chr22

39925985

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000221419HNRNPLchr1939334482-ENST00000334678RPS19BP1chr2239925922-187612473671476369

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000221419ENST00000334678HNRNPLchr1939334482-RPS19BP1chr2239925922-0.00444460.99555546

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Fusion Genomic Features for HNRNPL-RPS19BP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for HNRNPL-RPS19BP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:39334482/chr22:39925922)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPLchr19:39334482chr22:39925922ENST00000221419-61339_89293590.0Compositional biasNote=Gly-rich
HgeneHNRNPLchr19:39334482chr22:39925922ENST00000600873-61339_89160457.0Compositional biasNote=Gly-rich
HgeneHNRNPLchr19:39334482chr22:39925922ENST00000221419-613102_176293590.0DomainRRM 1
HgeneHNRNPLchr19:39334482chr22:39925922ENST00000221419-613193_270293590.0DomainRRM 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPLchr19:39334482chr22:39925922ENST00000221419-613335_382293590.0Compositional biasNote=Pro-rich
HgeneHNRNPLchr19:39334482chr22:39925922ENST00000600873-613335_382160457.0Compositional biasNote=Pro-rich
HgeneHNRNPLchr19:39334482chr22:39925922ENST00000221419-613382_478293590.0DomainRRM 3
HgeneHNRNPLchr19:39334482chr22:39925922ENST00000221419-613495_583293590.0DomainRRM 4
HgeneHNRNPLchr19:39334482chr22:39925922ENST00000600873-613102_176160457.0DomainRRM 1
HgeneHNRNPLchr19:39334482chr22:39925922ENST00000600873-613193_270160457.0DomainRRM 2
HgeneHNRNPLchr19:39334482chr22:39925922ENST00000600873-613382_478160457.0DomainRRM 3
HgeneHNRNPLchr19:39334482chr22:39925922ENST00000600873-613495_583160457.0DomainRRM 4


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Fusion Gene Sequence for HNRNPL-RPS19BP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37262_37262_1_HNRNPL-RPS19BP1_HNRNPL_chr19_39334482_ENST00000221419_RPS19BP1_chr22_39925922_ENST00000334678_length(transcript)=1876nt_BP=1247nt
GGAGACCAATGAAAGTGGGAGGGAGGCGGAGATTCTTGGGAGGTTTAGAGCGCCGTTCCTATCAGGTGCTTTTAGGGAGGCCAGCAGCGC
CAGAAATCCGACCTATCAAATTGGATTTTATTTTAAGGCGGCGGGGTCGACGGAAAGACTGGCAGAAAGCGACCACCTATAAGGAGTGTC
TCAGACAAACAAGGGCGGGCCCTCCTGCAGAACGGCGTGGGCAATGTCCAATAAGCGCGCAAGGCGTGTGGCGGCCTACCCTCCCCCCGC
GGCGGGACCAGTGGCTCCCCCTATCGGGTGGGGGCGGCGGGTGACGGGCGTGTCCCTCCCCCAATGAGAGGCGGGGGGAGGCGGGTTCTG
CGCCGCCATGTCGCGGAGGCTGCTGCCCCGGGCGGAGAAGCGGCGTCGGCGGCTGGAGCAGAGGCAGCAGCCGGACGAGCAGCGGAGGCG
GTCGGGAGCGATGGTGAAGATGGCGGCGGCGGGCGGCGGAGGCGGCGGTGGCCGCTACTACGGCGGCGGCAGTGAGGGCGGCCGGGCCCC
TAAGCGGCTCAAGACTGACAACGCCGGCGACCAGCACGGAGGCGGCGGCGGTGGCGGTGGAGGAGCCGGGGCGGCGGGCGGCGGCGGCGG
TGGGGAGAACTACGATGACCCGCACAAAACCCCTGCCTCCCCAGTTGTCCACATCAGGGGCCTGATTGACGGTGTGGTGGAAGCAGACCT
TGTGGAGGCCTTGCAGGAGTTTGGACCCATCAGCTATGTGGTGGTAATGCCTAAAAAGAGACAAGCACTGGTGGAGTTTGAAGATGTGTT
GGGGGCTTGCAACGCAGTGAACTACGCAGCCGACAACCAAATATACATTGCTGGTCACCCAGCTTTTGTCAACTACTCTACCAGCCAGAA
GATCTCCCGCCCTGGGGACTCGGATGACTCCCGGAGCGTGAACAGTGTGCTTCTCTTTACCATCCTGAACCCCATTTATTCGATCACCAC
GGATGTTCTTTACACTATCTGTAATCCTTGTGGCCCTGTCCAGAGAATTGTCATTTTCAGGAAGAATGGAGTTCAGGCGATGGTGGAATT
TGACTCAGTTCAAAGTGCCCAGCGGGCCAAGGCCTCTCTCAATGGGGCTGATATCTATTCTGGCTGTTGCACTCTGAAGATCGAATACGC
AAAGCCTACACGCTTGAATGTGTTCAAGAATGATCAGGATACTTGGGACTACACAAACCCCAATCTCAGTGGACAAGACGAGTACCGGAA
GCGAGAGTGTCGAGACCACCTCAGAGTAAACCTGAAGTTTCTGACCAGGACGAGAAGCACCGTGGCTGAGTCTGTGAGCCAGCAGATTTT
GCGCCAGAACCGGGGCCGCAAGGCCTGTGACCGGCCTGTGGCCAAGACCAAGAAGAAGAAGGCTGAGGGCACCGTGTTCACCGAGGAAGA
CTTCCAGAAGTTCCAGCAGGAATACTTCGGCAGCTAGGCTCCCTGGAGGGCACGGTGAAGAGGCCTTCAAGCCCTGCAGCCTCCGACTCC
TGCTGGCTCCAGGAACCGGCCGTGCCGCGCGGCCAGCAGATGGCGATGCAGGACCAGCCTGGCTCGAGGAAGCCGCGGAGCTGAGCCGAG
TGGAGGCTGGAATGGAGCTGGTGGGCCGGAAGTCCTGGGGAGGATTTACACACAGACCGGAGCTGGCTTCCGCAGGCCTGGGCAGAGCAT
CTGCACCTGCCGGAAAGGAACGTATCTGTTTTGTTTGCTTTTGCCCAGGTGGGGCCTCTGGGCTGTTTGCTGTGGAGCAAGGCTAATTCC

>37262_37262_1_HNRNPL-RPS19BP1_HNRNPL_chr19_39334482_ENST00000221419_RPS19BP1_chr22_39925922_ENST00000334678_length(amino acids)=369AA_BP=36
MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKRLKTDNAGDQHGGGGGGGGGAGAAGGGGGGE
NYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKIS
RPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKP
TRLNVFKNDQDTWDYTNPNLSGQDEYRKRECRDHLRVNLKFLTRTRSTVAESVSQQILRQNRGRKACDRPVAKTKKKKAEGTVFTEEDFQ

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Fusion Gene PPI Analysis for HNRNPL-RPS19BP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HNRNPL-RPS19BP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HNRNPL-RPS19BP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHNRNPLC0006142Malignant neoplasm of breast1CTD_human
HgeneHNRNPLC0024623Malignant neoplasm of stomach1CTD_human
HgeneHNRNPLC0038356Stomach Neoplasms1CTD_human
HgeneHNRNPLC0235874Disease Exacerbation1CTD_human
HgeneHNRNPLC0678222Breast Carcinoma1CTD_human
HgeneHNRNPLC1257931Mammary Neoplasms, Human1CTD_human
HgeneHNRNPLC1458155Mammary Neoplasms1CTD_human
HgeneHNRNPLC1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneHNRNPLC4704874Mammary Carcinoma, Human1CTD_human