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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ACACA-PPM1E (FusionGDB2 ID:HG31TG22843) |
Fusion Gene Summary for ACACA-PPM1E |
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Fusion gene information | Fusion gene name: ACACA-PPM1E | Fusion gene ID: hg31tg22843 | Hgene | Tgene | Gene symbol | ACACA | PPM1E | Gene ID | 31 | 22843 |
Gene name | acetyl-CoA carboxylase alpha | protein phosphatase, Mg2+/Mn2+ dependent 1E | |
Synonyms | ACAC|ACACAD|ACC|ACC1|ACCA | CaMKP-N|POPX1|PP2CH|caMKN | |
Cytomap | ('ACACA')('PPM1E') 17q12 | 17q22 | |
Type of gene | protein-coding | protein-coding | |
Description | acetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alpha | protein phosphatase 1Eca(2+)/calmodulin-dependent protein kinase phosphatase NcaMKP-nucleusnuclear calmodulin-dependent protein kinase phosphatasepartner of PIX 1partner of PIX-alphapartner of PIXAprotein phosphatase 1E (PP2C domain containing) | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000335166, ENST00000394406, ENST00000353139, ENST00000360679, ENST00000361253, ENST00000416895, ENST00000588142, ENST00000589665, | ||
Fusion gene scores | * DoF score | 44 X 35 X 17=26180 | 11 X 7 X 4=308 |
# samples | 51 | 10 | |
** MAII score | log2(51/26180*10)=-5.68182403997375 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/308*10)=-1.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACACA [Title/Abstract] AND PPM1E [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ACACA(35614625)-PPM1E(57033010), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | ACACA-PPM1E seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACACA-PPM1E seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACACA-PPM1E seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACACA-PPM1E seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACACA-PPM1E seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ACACA-PPM1E seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ACACA-PPM1E seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PPM1E | GO:0006469 | negative regulation of protein kinase activity | 11864573 |
Tgene | PPM1E | GO:0035690 | cellular response to drug | 20801214 |
Tgene | PPM1E | GO:0035970 | peptidyl-threonine dephosphorylation | 20801214 |
Tgene | PPM1E | GO:0051496 | positive regulation of stress fiber assembly | 11864573 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-BR-8080-01A | ACACA | chr17 | 35614625 | - | PPM1E | chr17 | 57033010 | + |
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Fusion Gene ORF analysis for ACACA-PPM1E |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000335166 | ENST00000308249 | ACACA | chr17 | 35614625 | - | PPM1E | chr17 | 57033010 | + |
Frame-shift | ENST00000394406 | ENST00000308249 | ACACA | chr17 | 35614625 | - | PPM1E | chr17 | 57033010 | + |
In-frame | ENST00000353139 | ENST00000308249 | ACACA | chr17 | 35614625 | - | PPM1E | chr17 | 57033010 | + |
In-frame | ENST00000360679 | ENST00000308249 | ACACA | chr17 | 35614625 | - | PPM1E | chr17 | 57033010 | + |
intron-3CDS | ENST00000361253 | ENST00000308249 | ACACA | chr17 | 35614625 | - | PPM1E | chr17 | 57033010 | + |
intron-3CDS | ENST00000416895 | ENST00000308249 | ACACA | chr17 | 35614625 | - | PPM1E | chr17 | 57033010 | + |
intron-3CDS | ENST00000588142 | ENST00000308249 | ACACA | chr17 | 35614625 | - | PPM1E | chr17 | 57033010 | + |
intron-3CDS | ENST00000589665 | ENST00000308249 | ACACA | chr17 | 35614625 | - | PPM1E | chr17 | 57033010 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000353139 | ACACA | chr17 | 35614625 | - | ENST00000308249 | PPM1E | chr17 | 57033010 | + | 4703 | 2308 | 461 | 4111 | 1216 |
ENST00000360679 | ACACA | chr17 | 35614625 | - | ENST00000308249 | PPM1E | chr17 | 57033010 | + | 4371 | 1976 | 297 | 3779 | 1160 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000353139 | ENST00000308249 | ACACA | chr17 | 35614625 | - | PPM1E | chr17 | 57033010 | + | 0.001699044 | 0.99830097 |
ENST00000360679 | ENST00000308249 | ACACA | chr17 | 35614625 | - | PPM1E | chr17 | 57033010 | + | 0.001643178 | 0.99835676 |
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Fusion Genomic Features for ACACA-PPM1E |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ACACA | chr17 | 35614624 | - | PPM1E | chr17 | 57033009 | + | 7.88E-10 | 1 |
ACACA | chr17 | 35614624 | - | PPM1E | chr17 | 57033009 | + | 7.88E-10 | 1 |
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Fusion Protein Features for ACACA-PPM1E |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:35614625/chr17:57033010) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000335166 | - | 13 | 55 | 275_466 | 493 | 2269.0 | Domain | ATP-grasp |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000353139 | - | 14 | 56 | 275_466 | 608 | 2384.0 | Domain | ATP-grasp |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000360679 | - | 12 | 54 | 275_466 | 513 | 2289.0 | Domain | ATP-grasp |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000394406 | - | 14 | 56 | 275_466 | 571 | 2347.0 | Domain | ATP-grasp |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000335166 | - | 13 | 55 | 315_320 | 493 | 2269.0 | Nucleotide binding | ATP |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000353139 | - | 14 | 56 | 315_320 | 608 | 2384.0 | Nucleotide binding | ATP |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000360679 | - | 12 | 54 | 315_320 | 513 | 2289.0 | Nucleotide binding | ATP |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000394406 | - | 14 | 56 | 315_320 | 571 | 2347.0 | Nucleotide binding | ATP |
Tgene | PPM1E | chr17:35614625 | chr17:57033010 | ENST00000308249 | 0 | 7 | 231_488 | 154 | 756.0 | Domain | PPM-type phosphatase |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000335166 | - | 13 | 55 | 117_618 | 493 | 2269.0 | Domain | Biotin carboxylation |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000335166 | - | 13 | 55 | 1576_1914 | 493 | 2269.0 | Domain | CoA carboxyltransferase N-terminal |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000335166 | - | 13 | 55 | 1918_2234 | 493 | 2269.0 | Domain | CoA carboxyltransferase C-terminal |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000335166 | - | 13 | 55 | 745_819 | 493 | 2269.0 | Domain | Biotinyl-binding |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000353139 | - | 14 | 56 | 117_618 | 608 | 2384.0 | Domain | Biotin carboxylation |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000353139 | - | 14 | 56 | 1576_1914 | 608 | 2384.0 | Domain | CoA carboxyltransferase N-terminal |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000353139 | - | 14 | 56 | 1918_2234 | 608 | 2384.0 | Domain | CoA carboxyltransferase C-terminal |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000353139 | - | 14 | 56 | 745_819 | 608 | 2384.0 | Domain | Biotinyl-binding |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000360679 | - | 12 | 54 | 117_618 | 513 | 2289.0 | Domain | Biotin carboxylation |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000360679 | - | 12 | 54 | 1576_1914 | 513 | 2289.0 | Domain | CoA carboxyltransferase N-terminal |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000360679 | - | 12 | 54 | 1918_2234 | 513 | 2289.0 | Domain | CoA carboxyltransferase C-terminal |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000360679 | - | 12 | 54 | 745_819 | 513 | 2289.0 | Domain | Biotinyl-binding |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000394406 | - | 14 | 56 | 117_618 | 571 | 2347.0 | Domain | Biotin carboxylation |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000394406 | - | 14 | 56 | 1576_1914 | 571 | 2347.0 | Domain | CoA carboxyltransferase N-terminal |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000394406 | - | 14 | 56 | 1918_2234 | 571 | 2347.0 | Domain | CoA carboxyltransferase C-terminal |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000394406 | - | 14 | 56 | 745_819 | 571 | 2347.0 | Domain | Biotinyl-binding |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000335166 | - | 13 | 55 | 1576_2234 | 493 | 2269.0 | Region | Carboxyltransferase |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000353139 | - | 14 | 56 | 1576_2234 | 608 | 2384.0 | Region | Carboxyltransferase |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000360679 | - | 12 | 54 | 1576_2234 | 513 | 2289.0 | Region | Carboxyltransferase |
Hgene | ACACA | chr17:35614625 | chr17:57033010 | ENST00000394406 | - | 14 | 56 | 1576_2234 | 571 | 2347.0 | Region | Carboxyltransferase |
Tgene | PPM1E | chr17:35614625 | chr17:57033010 | ENST00000308249 | 0 | 7 | 7_100 | 154 | 756.0 | Compositional bias | Note=Glu-rich | |
Tgene | PPM1E | chr17:35614625 | chr17:57033010 | ENST00000308249 | 0 | 7 | 31_52 | 154 | 756.0 | Region | Note=11 X 2 AA tandem repeats of P-E | |
Tgene | PPM1E | chr17:35614625 | chr17:57033010 | ENST00000308249 | 0 | 7 | 31_32 | 154 | 756.0 | Repeat | Note=1 | |
Tgene | PPM1E | chr17:35614625 | chr17:57033010 | ENST00000308249 | 0 | 7 | 33_34 | 154 | 756.0 | Repeat | Note=2 | |
Tgene | PPM1E | chr17:35614625 | chr17:57033010 | ENST00000308249 | 0 | 7 | 35_36 | 154 | 756.0 | Repeat | Note=3 | |
Tgene | PPM1E | chr17:35614625 | chr17:57033010 | ENST00000308249 | 0 | 7 | 37_38 | 154 | 756.0 | Repeat | Note=4 | |
Tgene | PPM1E | chr17:35614625 | chr17:57033010 | ENST00000308249 | 0 | 7 | 39_40 | 154 | 756.0 | Repeat | Note=5 | |
Tgene | PPM1E | chr17:35614625 | chr17:57033010 | ENST00000308249 | 0 | 7 | 41_42 | 154 | 756.0 | Repeat | Note=6 | |
Tgene | PPM1E | chr17:35614625 | chr17:57033010 | ENST00000308249 | 0 | 7 | 43_44 | 154 | 756.0 | Repeat | Note=7 | |
Tgene | PPM1E | chr17:35614625 | chr17:57033010 | ENST00000308249 | 0 | 7 | 45_46 | 154 | 756.0 | Repeat | Note=8%3B approximate | |
Tgene | PPM1E | chr17:35614625 | chr17:57033010 | ENST00000308249 | 0 | 7 | 47_48 | 154 | 756.0 | Repeat | Note=9 | |
Tgene | PPM1E | chr17:35614625 | chr17:57033010 | ENST00000308249 | 0 | 7 | 49_50 | 154 | 756.0 | Repeat | Note=10 | |
Tgene | PPM1E | chr17:35614625 | chr17:57033010 | ENST00000308249 | 0 | 7 | 51_52 | 154 | 756.0 | Repeat | Note=11 |
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Fusion Gene Sequence for ACACA-PPM1E |
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>1167_1167_1_ACACA-PPM1E_ACACA_chr17_35614625_ENST00000353139_PPM1E_chr17_57033010_ENST00000308249_length(transcript)=4703nt_BP=2308nt GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGGTCTTTCTGGAAGTGGATAT CTACTCAGACAGTAAGAATTATAAGAGCTGTAAGAGCTCATTTTGGAGGAATAATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGC TGAACCAGCACTCTCGATTCATAATAGGTTCTGTGTCTGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGTTGGACCTACTGG AGGAGAAGGAGGGCTCCTTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCTGATTTGGGGATCTCTAGCCTACAGGATGGCTTGGCCT TGCACATAAGGTCCAGCATGTCTGGCTTGCACCTAGTAAAGCAGGGCCGAGACAGAAAGAAAATAGATTCTCAACGAGATTTCACTGTGG CTTCTCCAGCAGAATTTGTTACTCGCTTTGGGGGAAATAAAGTGATTGAGAAGGTTCTTATTGCTAACAATGGCATTGCAGCAGTGAAAT GCATGCGGTCTATCCGTAGGTGGTCTTATGAAATGTTTCGAAATGAACGTGCAATTAGATTCGTTGTCATGGTCACACCTGAAGACCTTA AAGCCAATGCAGAATACATTAAGATGGCAGATCACTATGTGCCAGTGCCTGGAGGACCAAACAACAACAACTATGCAAATGTGGAATTAA TTCTTGATATTGCTAAAAGGATCCCAGTACAAGCAGTGTGGGCTGGCTGGGGTCATGCTTCTGAGAATCCCAAACTACCGGAACTTCTCT TGAAAAATGGCATTGCCTTCATGGGTCCTCCAAGCCAGGCCATGTGGGCTTTAGGGGATAAGATTGCATCTTCCATAGTGGCTCAAACTG CAGGTATCCCAACTCTTCCCTGGAGCGGCAGTGGTCTTCGTGTGGACTGGCAGGAAAATGATTTTTCAAAACGTATCTTAAATGTTCCCC AGGAGCTATATGAAAAAGGTTATGTGAAAGATGTGGATGATGGGCTACAGGCAGCTGAGGAAGTTGGATATCCAGTAATGATCAAGGCCT CAGAGGGAGGAGGAGGGAAGGGAATTAGAAAAGTCAACAATGCAGATGACTTCCCTAATCTCTTCAGACAGGTTCAAGCTGAAGTTCCTG GATCTCCCATATTTGTGATGAGACTAGCCAAACAATCTCGTCATCTGGAGGTGCAGATCTTAGCGGACCAATATGGCAATGCTATCTCTT TGTTTGGTCGTGATTGCTCTGTACAACGCAGGCATCAGAAGATTATTGAAGAAGCACCTGCTACTATTGCTACTCCAGCAGTATTTGAAC ACATGGAACAGTGTGCGGTGAAACTTGCCAAAATGGTGGGTTATGTGAGTGCTGGGACTGTGGAATACCTGTACAGCCAGGATGGCAGCT TCTACTTTCTGGAATTGAATCCTCGGCTGCAGGTAGAGCACCCTTGTACAGAGATGGTGGCTGATGTCAATCTCCCTGCAGCACAGCTCC AGATTGCCATGGGGATTCCTCTATATAGAATCAAGGATATCCGTATGATGTATGGGGTATCTCCCTGGGGTGATTCTCCCATTGATTTTG AAGATTCTGCACACGTTCCTTGTCCAAGGGGCCATGTTATTGCTGCTCGGATCACTAGTGAAAATCCAGATGAGGGTTTTAAGCCCAGCT CAGGAACAGTTCAGGAGCTAAATTTCCGCAGCAATAAGAATGTTTGGGGATATTTCAGTGTTGCTGCTGCAGGGGGACTTCATGAATTTG CTGATTCTCAGTTTGGTCACTGCTTTTCTTGGGGAGAAAACAGAGAAGAGGCAATTTCTAATTGCCCTTCCTTTTTGGCTGCTGCTTTAG CCAGAGCCACATCAGATGAAGTCCTTCAGAGTGATCTTTCTGCACATTATATCCCAAAGGAAACGGATGGCACAGAAGGGACTGTGGAGA TTGAGACAGTGAAATTGGCCCGTTCTGTCTTCAGCAAACTACACGAGATTTGCTGCAGCTGGGTGAAAGACTTCCCCCTCCGCAGGAGAC CCCAGCTTTATTATGAGACATCAATCCATGCCATCAAAAACATGCGCAGGAAAATGGAGGACAAACATGTCTGCATTCCTGACTTTAATA TGCTCTTCAACCTAGAGGACCAGGAAGAACAAGCTTACTTTGCAGTGTTTGATGGCCATGGGGGAGTAGATGCTGCTATTTATGCCTCCA TTCACCTCCACGTTAACTTAGTCCGCCAGGAGATGTTCCCCCATGATCCTGCTGAGGCCCTGTGCAGGGCCTTCCGGGTCACTGATGAGC GGTTTGTGCAGAAAGCAGCCAGGGAGAGCTTAAGATGTGGGACCACAGGAGTGGTGACTTTCATCAGAGGCAACATGCTACATGTGGCCT GGGTGGGTGATTCCCAGGTTATGCTTGTGAGAAAGGGCCAAGCTGTTGAACTAATGAAGCCACACAAACCAGACAGAGAGGATGAAAAGC AGAGAATTGAGGCCCTTGGAGGTTGCGTAGTCTGGTTTGGTGCCTGGAGGGTGAATGGAAGTCTGTCGGTTTCCAGAGCTATTGGAGATG CTGAACATAAGCCATATATCTGTGGGGATGCAGATTCTGCCTCCACTGTTCTGGATGGGACCGAAGACTACCTCATTCTGGCCTGTGATG GCTTCTATGACACCGTGAACCCTGATGAGGCAGTGAAAGTTGTGTCCGACCACCTGAAAGAGAATAATGGAGACAGCAGCATGGTTGCCC ACAAATTAGTGGCATCAGCTCGTGATGCTGGGTCAAGTGATAACATCACGGTTATTGTGGTATTCCTGAGGGACATGAACAAAGCTGTAA ATGTTAGTGAGGAATCAGATTGGACAGAGAACTCTTTTCAAGGAGGGCAAGAAGATGGTGGGGATGATAAGGAGAATCATGGAGAGTGCA AACGCCCTTGGCCTCAGCACCAGTGCTCAGCACCAGCCGACCTAGGCTATGATGGGCGTGTGGATTCATTCACTGATAGAACTAGCCTGA GCCCAGGGTCCCAAATCAACGTGCTGGAAGACCCAGGCTACCTAGATCTCACACAAATAGAAGCAAGCAAACCTCACAGTGCCCAGTTTT TGCTACCAGTTGAGATGTTTGGTCCTGGTGCACCAAAGAAAGCAAATCTTATTAATGAGTTAATGATGGAGAAAAAATCAGTTCAGTCAT CATTGCCTGAATGGAGTGGTGCTGGAGAGTTTCCCACTGCTTTCAATTTGGGTTCAACAGGGGAGCAGATATACAGAATGCAGAGCTTGT CTCCTGTCTGTTCAGGGTTGGAAAATGAACAGTTCAAATCCCCGGGAAACAGAGTTTCTAGATTGTCTCATTTACGCCACCACTACTCAA AGAAGTGGCACAGATTCAGGTTTAATCCAAAGTTTTATTCATTTCTCTCTGCTCAAGAGCCTTCCCACAAAATAGGCACTAGCCTGTCCT CACTTACTGGAAGTGGGAAGAGAAATAGGATAAGAAGTTCTCTGCCATGGAGGCAAAATAGTTGGAAAGGGTACAGTGAAAACATGAGGA AGCTCAGAAAGACTCATGATATTCCATGCCCAGATCTTCCTTGGAGCTATAAAATAGAATAATTTTTCTTTCAAGTAGGTTAGCTAGCTC TCCCCCAATAAAAATACCACTATCAGAGTAGAAACAAGGTAGACATTTCTAAAACATATGTGCTTCATTATGAATCCATGGATGGCTCAA TTCTTAAATGTAAATAGATCTCTAGGAAACTCAAAGTACAGTGTTTTCAATCTAAAAAGAAGTATTGGCAGTTTCACTTGCAAAATTACA CAGCTGGTCCCTGTGATGTGTCTCGACACCAATACACAACCCCCTTCCCACCATCCTTCATGTCACTAGATACACAACCCCCTTCCCACC ATCCCTTCAGTCACTAGTGGAAGCTTTCAAGTTAGTTATTTCAGTCAGGATATACAGTGTTGAAATCTCAATGCAGTTGAAATCTGGTCT GATGTGCCTAATTTATCTGTGGAAAATTTAATGCTGAATTACATTTGGTTGGGAAATGTCCCTCAAAATCCTGGGCACTATGAAGGAACC CCCTGCCCCCTCACCTTTTTGGGTAGGTAAAAGACTAAAAGCCATATGGATTTTAACTGATAACAATGAAAGTGGTAAATCAGTGTAAAA >1167_1167_1_ACACA-PPM1E_ACACA_chr17_35614625_ENST00000353139_PPM1E_chr17_57033010_ENST00000308249_length(amino acids)=1216AA_BP=615 MRRNDERMWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKE GSLSPASVGSDTLSDLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRS IRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNG IAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGG GGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQ CAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSA HVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNCPSFLAAALARAT SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFN LEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGFYD TVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPVEMFGPGAPKKANLINELMMEKKSVQSSLPE WSGAGEFPTAFNLGSTGEQIYRMQSLSPVCSGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG -------------------------------------------------------------- >1167_1167_2_ACACA-PPM1E_ACACA_chr17_35614625_ENST00000360679_PPM1E_chr17_57033010_ENST00000308249_length(transcript)=4371nt_BP=1976nt GGCAGCCAGGAGAGGCAGTGGAGCTTTTCTCCGTTGACTGTCAGAAGAAAGTGACTGTTGTTGAAAATGTTTGCTGCAACTAAAGGAGAG CTGCTAAGATCTACTTTCTAGTTAAACAAGCTTTTATATTTCTCCCCGGCTCCTCTCAGTTCCCTTGGGAAATCAACTAATTGTGTGTGT AAGCTAAGTGTGTGGAGGAGAGAAGATGCAAAAAGGAAGAGAAAGGTGGGGAAAGAAGGAAATTGGGAACAATTAGACAAAAAGACTATA GTTTGAGGCCATCAGGAGTATTCTAGTCTGACTGAAGCCAGGCAGAAGGCACAGTATCTCTTGTCCTCCTGGGTTTTAAGCAGCTGCAAC AGGAGGAGGAACTGCGGCTTGTGTTTACAAGGCCGAAATCTGAAGAAAAAGCTTCCATTCTTTTCCCATCTTGATATGGAGGGTTCTCCA GAGGAAAATAAGGAAATGAGATATTACATGCTTCAAAGGTCCAGCATGTCTGGCTTGCACCTAGTAAAGCAGGGCCGAGACAGAAAGAAA ATAGATTCTCAACGAGATTTCACTGTGGCTTCTCCAGCAGAATTTGTTACTCGCTTTGGGGGAAATAAAGTGATTGAGAAGGTTCTTATT GCTAACAATGGCATTGCAGCAGTGAAATGCATGCGGTCTATCCGTAGGTGGTCTTATGAAATGTTTCGAAATGAACGTGCAATTAGATTC GTTGTCATGGTCACACCTGAAGACCTTAAAGCCAATGCAGAATACATTAAGATGGCAGATCACTATGTGCCAGTGCCTGGAGGACCAAAC AACAACAACTATGCAAATGTGGAATTAATTCTTGATATTGCTAAAAGGATCCCAGTACAAGCAGTGTGGGCTGGCTGGGGTCATGCTTCT GAGAATCCCAAACTACCGGAACTTCTCTTGAAAAATGGCATTGCCTTCATGGGTCCTCCAAGCCAGGCCATGTGGGCTTTAGGGGATAAG ATTGCATCTTCCATAGTGGCTCAAACTGCAGGTATCCCAACTCTTCCCTGGAGCGGCAGTGGTCTTCGTGTGGACTGGCAGGAAAATGAT TTTTCAAAACGTATCTTAAATGTTCCCCAGGAGCTATATGAAAAAGGTTATGTGAAAGATGTGGATGATGGGCTACAGGCAGCTGAGGAA GTTGGATATCCAGTAATGATCAAGGCCTCAGAGGGAGGAGGAGGGAAGGGAATTAGAAAAGTCAACAATGCAGATGACTTCCCTAATCTC TTCAGACAGGTTCAAGCTGAAGTTCCTGGATCTCCCATATTTGTGATGAGACTAGCCAAACAATCTCGTCATCTGGAGGTGCAGATCTTA GCGGACCAATATGGCAATGCTATCTCTTTGTTTGGTCGTGATTGCTCTGTACAACGCAGGCATCAGAAGATTATTGAAGAAGCACCTGCT ACTATTGCTACTCCAGCAGTATTTGAACACATGGAACAGTGTGCGGTGAAACTTGCCAAAATGGTGGGTTATGTGAGTGCTGGGACTGTG GAATACCTGTACAGCCAGGATGGCAGCTTCTACTTTCTGGAATTGAATCCTCGGCTGCAGGTAGAGCACCCTTGTACAGAGATGGTGGCT GATGTCAATCTCCCTGCAGCACAGCTCCAGATTGCCATGGGGATTCCTCTATATAGAATCAAGGATATCCGTATGATGTATGGGGTATCT CCCTGGGGTGATTCTCCCATTGATTTTGAAGATTCTGCACACGTTCCTTGTCCAAGGGGCCATGTTATTGCTGCTCGGATCACTAGTGAA AATCCAGATGAGGGTTTTAAGCCCAGCTCAGGAACAGTTCAGGAGCTAAATTTCCGCAGCAATAAGAATGTTTGGGGATATTTCAGTGTT GCTGCTGCAGGGGGACTTCATGAATTTGCTGATTCTCAGTTTGGTCACTGCTTTTCTTGGGGAGAAAACAGAGAAGAGGCAATTTCTAAT TGCCCTTCCTTTTTGGCTGCTGCTTTAGCCAGAGCCACATCAGATGAAGTCCTTCAGAGTGATCTTTCTGCACATTATATCCCAAAGGAA ACGGATGGCACAGAAGGGACTGTGGAGATTGAGACAGTGAAATTGGCCCGTTCTGTCTTCAGCAAACTACACGAGATTTGCTGCAGCTGG GTGAAAGACTTCCCCCTCCGCAGGAGACCCCAGCTTTATTATGAGACATCAATCCATGCCATCAAAAACATGCGCAGGAAAATGGAGGAC AAACATGTCTGCATTCCTGACTTTAATATGCTCTTCAACCTAGAGGACCAGGAAGAACAAGCTTACTTTGCAGTGTTTGATGGCCATGGG GGAGTAGATGCTGCTATTTATGCCTCCATTCACCTCCACGTTAACTTAGTCCGCCAGGAGATGTTCCCCCATGATCCTGCTGAGGCCCTG TGCAGGGCCTTCCGGGTCACTGATGAGCGGTTTGTGCAGAAAGCAGCCAGGGAGAGCTTAAGATGTGGGACCACAGGAGTGGTGACTTTC ATCAGAGGCAACATGCTACATGTGGCCTGGGTGGGTGATTCCCAGGTTATGCTTGTGAGAAAGGGCCAAGCTGTTGAACTAATGAAGCCA CACAAACCAGACAGAGAGGATGAAAAGCAGAGAATTGAGGCCCTTGGAGGTTGCGTAGTCTGGTTTGGTGCCTGGAGGGTGAATGGAAGT CTGTCGGTTTCCAGAGCTATTGGAGATGCTGAACATAAGCCATATATCTGTGGGGATGCAGATTCTGCCTCCACTGTTCTGGATGGGACC GAAGACTACCTCATTCTGGCCTGTGATGGCTTCTATGACACCGTGAACCCTGATGAGGCAGTGAAAGTTGTGTCCGACCACCTGAAAGAG AATAATGGAGACAGCAGCATGGTTGCCCACAAATTAGTGGCATCAGCTCGTGATGCTGGGTCAAGTGATAACATCACGGTTATTGTGGTA TTCCTGAGGGACATGAACAAAGCTGTAAATGTTAGTGAGGAATCAGATTGGACAGAGAACTCTTTTCAAGGAGGGCAAGAAGATGGTGGG GATGATAAGGAGAATCATGGAGAGTGCAAACGCCCTTGGCCTCAGCACCAGTGCTCAGCACCAGCCGACCTAGGCTATGATGGGCGTGTG GATTCATTCACTGATAGAACTAGCCTGAGCCCAGGGTCCCAAATCAACGTGCTGGAAGACCCAGGCTACCTAGATCTCACACAAATAGAA GCAAGCAAACCTCACAGTGCCCAGTTTTTGCTACCAGTTGAGATGTTTGGTCCTGGTGCACCAAAGAAAGCAAATCTTATTAATGAGTTA ATGATGGAGAAAAAATCAGTTCAGTCATCATTGCCTGAATGGAGTGGTGCTGGAGAGTTTCCCACTGCTTTCAATTTGGGTTCAACAGGG GAGCAGATATACAGAATGCAGAGCTTGTCTCCTGTCTGTTCAGGGTTGGAAAATGAACAGTTCAAATCCCCGGGAAACAGAGTTTCTAGA TTGTCTCATTTACGCCACCACTACTCAAAGAAGTGGCACAGATTCAGGTTTAATCCAAAGTTTTATTCATTTCTCTCTGCTCAAGAGCCT TCCCACAAAATAGGCACTAGCCTGTCCTCACTTACTGGAAGTGGGAAGAGAAATAGGATAAGAAGTTCTCTGCCATGGAGGCAAAATAGT TGGAAAGGGTACAGTGAAAACATGAGGAAGCTCAGAAAGACTCATGATATTCCATGCCCAGATCTTCCTTGGAGCTATAAAATAGAATAA TTTTTCTTTCAAGTAGGTTAGCTAGCTCTCCCCCAATAAAAATACCACTATCAGAGTAGAAACAAGGTAGACATTTCTAAAACATATGTG CTTCATTATGAATCCATGGATGGCTCAATTCTTAAATGTAAATAGATCTCTAGGAAACTCAAAGTACAGTGTTTTCAATCTAAAAAGAAG TATTGGCAGTTTCACTTGCAAAATTACACAGCTGGTCCCTGTGATGTGTCTCGACACCAATACACAACCCCCTTCCCACCATCCTTCATG TCACTAGATACACAACCCCCTTCCCACCATCCCTTCAGTCACTAGTGGAAGCTTTCAAGTTAGTTATTTCAGTCAGGATATACAGTGTTG AAATCTCAATGCAGTTGAAATCTGGTCTGATGTGCCTAATTTATCTGTGGAAAATTTAATGCTGAATTACATTTGGTTGGGAAATGTCCC TCAAAATCCTGGGCACTATGAAGGAACCCCCTGCCCCCTCACCTTTTTGGGTAGGTAAAAGACTAAAAGCCATATGGATTTTAACTGATA >1167_1167_2_ACACA-PPM1E_ACACA_chr17_35614625_ENST00000360679_PPM1E_chr17_57033010_ENST00000308249_length(amino acids)=1160AA_BP=559 MTEARQKAQYLLSSWVLSSCNRRRNCGLCLQGRNLKKKLPFFSHLDMEGSPEENKEMRYYMLQRSSMSGLHLVKQGRDRKKIDSQRDFTV ASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVEL ILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVP QELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAIS LFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQL QIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEF ADSQFGHCFSWGENREEAISNCPSFLAAALARATSDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRR PQLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDPAEALCRAFRVTDE RFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGD AEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAV NVSEESDWTENSFQGGQEDGGDDKENHGECKRPWPQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQF LLPVEMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVCSGLENEQFKSPGNRVSRLSHLRHHYS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ACACA-PPM1E |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACACA-PPM1E |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ACACA-PPM1E |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACACA | C0018801 | Heart failure | 1 | CTD_human |
Hgene | ACACA | C0018802 | Congestive heart failure | 1 | CTD_human |
Hgene | ACACA | C0023212 | Left-Sided Heart Failure | 1 | CTD_human |
Hgene | ACACA | C0235527 | Heart Failure, Right-Sided | 1 | CTD_human |
Hgene | ACACA | C1959583 | Myocardial Failure | 1 | CTD_human |
Hgene | ACACA | C1961112 | Heart Decompensation | 1 | CTD_human |
Hgene | ACACA | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | C0009402 | Colorectal Carcinoma | 1 | CTD_human | |
Tgene | C0009404 | Colorectal Neoplasms | 1 | CTD_human |