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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ACACA-MMP28 (FusionGDB2 ID:HG31TG79148) |
Fusion Gene Summary for ACACA-MMP28 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACACA-MMP28 | Fusion gene ID: hg31tg79148 | Hgene | Tgene | Gene symbol | ACACA | MMP28 | Gene ID | 31 | 79148 |
| Gene name | acetyl-CoA carboxylase alpha | matrix metallopeptidase 28 | |
| Synonyms | ACAC|ACACAD|ACC|ACC1|ACCA | EPILYSIN|MM28|MMP-25|MMP-28|MMP25 | |
| Cytomap | ('ACACA')('MMP28') 17q12 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | acetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alpha | matrix metalloproteinase-28matrix metalloprotease MMP25 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000335166, ENST00000394406, ENST00000353139, ENST00000360679, ENST00000361253, ENST00000416895, ENST00000588142, ENST00000589665, | ||
| Fusion gene scores | * DoF score | 44 X 35 X 17=26180 | 3 X 4 X 3=36 |
| # samples | 51 | 3 | |
| ** MAII score | log2(51/26180*10)=-5.68182403997375 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ACACA [Title/Abstract] AND MMP28 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ACACA(35454765)-MMP28(34106327), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | ACACA-MMP28 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACACA-MMP28 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACACA-MMP28 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACACA-MMP28 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACACA-MMP28 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ACACA-MMP28 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ACACA-MMP28 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across ACACA (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MMP28 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-V1-A8ML-01A | ACACA | chr17 | 35454765 | - | MMP28 | chr17 | 34106327 | - |
| ChimerDB4 | PRAD | TCGA-V1-A8ML | ACACA | chr17 | 35454765 | - | MMP28 | chr17 | 34106327 | - |
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Fusion Gene ORF analysis for ACACA-MMP28 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000335166 | ENST00000250144 | ACACA | chr17 | 35454765 | - | MMP28 | chr17 | 34106327 | - |
| Frame-shift | ENST00000394406 | ENST00000250144 | ACACA | chr17 | 35454765 | - | MMP28 | chr17 | 34106327 | - |
| In-frame | ENST00000353139 | ENST00000250144 | ACACA | chr17 | 35454765 | - | MMP28 | chr17 | 34106327 | - |
| In-frame | ENST00000360679 | ENST00000250144 | ACACA | chr17 | 35454765 | - | MMP28 | chr17 | 34106327 | - |
| In-frame | ENST00000361253 | ENST00000250144 | ACACA | chr17 | 35454765 | - | MMP28 | chr17 | 34106327 | - |
| intron-3CDS | ENST00000416895 | ENST00000250144 | ACACA | chr17 | 35454765 | - | MMP28 | chr17 | 34106327 | - |
| intron-3CDS | ENST00000588142 | ENST00000250144 | ACACA | chr17 | 35454765 | - | MMP28 | chr17 | 34106327 | - |
| intron-3CDS | ENST00000589665 | ENST00000250144 | ACACA | chr17 | 35454765 | - | MMP28 | chr17 | 34106327 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000353139 | ACACA | chr17 | 35454765 | - | ENST00000250144 | MMP28 | chr17 | 34106327 | - | 7853 | 7202 | 461 | 7483 | 2340 |
| ENST00000360679 | ACACA | chr17 | 35454765 | - | ENST00000250144 | MMP28 | chr17 | 34106327 | - | 7521 | 6870 | 297 | 7151 | 2284 |
| ENST00000361253 | ACACA | chr17 | 35454765 | - | ENST00000250144 | MMP28 | chr17 | 34106327 | - | 1956 | 1305 | 195 | 1586 | 463 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000353139 | ENST00000250144 | ACACA | chr17 | 35454765 | - | MMP28 | chr17 | 34106327 | - | 0.001038794 | 0.9989612 |
| ENST00000360679 | ENST00000250144 | ACACA | chr17 | 35454765 | - | MMP28 | chr17 | 34106327 | - | 0.001047609 | 0.9989524 |
| ENST00000361253 | ENST00000250144 | ACACA | chr17 | 35454765 | - | MMP28 | chr17 | 34106327 | - | 0.001787738 | 0.99821234 |
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Fusion Genomic Features for ACACA-MMP28 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ACACA-MMP28 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:35454765/chr17:34106327) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000335166 | - | 52 | 55 | 117_618 | 2125 | 2269.0 | Domain | Biotin carboxylation |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000335166 | - | 52 | 55 | 1576_1914 | 2125 | 2269.0 | Domain | CoA carboxyltransferase N-terminal |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000335166 | - | 52 | 55 | 275_466 | 2125 | 2269.0 | Domain | ATP-grasp |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000335166 | - | 52 | 55 | 745_819 | 2125 | 2269.0 | Domain | Biotinyl-binding |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000353139 | - | 53 | 56 | 117_618 | 2240 | 2384.0 | Domain | Biotin carboxylation |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000353139 | - | 53 | 56 | 1576_1914 | 2240 | 2384.0 | Domain | CoA carboxyltransferase N-terminal |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000353139 | - | 53 | 56 | 1918_2234 | 2240 | 2384.0 | Domain | CoA carboxyltransferase C-terminal |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000353139 | - | 53 | 56 | 275_466 | 2240 | 2384.0 | Domain | ATP-grasp |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000353139 | - | 53 | 56 | 745_819 | 2240 | 2384.0 | Domain | Biotinyl-binding |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000360679 | - | 51 | 54 | 117_618 | 2145 | 2289.0 | Domain | Biotin carboxylation |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000360679 | - | 51 | 54 | 1576_1914 | 2145 | 2289.0 | Domain | CoA carboxyltransferase N-terminal |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000360679 | - | 51 | 54 | 275_466 | 2145 | 2289.0 | Domain | ATP-grasp |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000360679 | - | 51 | 54 | 745_819 | 2145 | 2289.0 | Domain | Biotinyl-binding |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000394406 | - | 53 | 56 | 117_618 | 2203 | 2347.0 | Domain | Biotin carboxylation |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000394406 | - | 53 | 56 | 1576_1914 | 2203 | 2347.0 | Domain | CoA carboxyltransferase N-terminal |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000394406 | - | 53 | 56 | 275_466 | 2203 | 2347.0 | Domain | ATP-grasp |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000394406 | - | 53 | 56 | 745_819 | 2203 | 2347.0 | Domain | Biotinyl-binding |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000335166 | - | 52 | 55 | 315_320 | 2125 | 2269.0 | Nucleotide binding | ATP |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000353139 | - | 53 | 56 | 315_320 | 2240 | 2384.0 | Nucleotide binding | ATP |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000360679 | - | 51 | 54 | 315_320 | 2145 | 2289.0 | Nucleotide binding | ATP |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000394406 | - | 53 | 56 | 315_320 | 2203 | 2347.0 | Nucleotide binding | ATP |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000353139 | - | 53 | 56 | 1576_2234 | 2240 | 2384.0 | Region | Carboxyltransferase |
| Tgene | MMP28 | chr17:35454765 | chr17:34106327 | ENST00000250144 | 0 | 3 | 89_96 | 37 | 131.0 | Motif | Cysteine switch | |
| Tgene | MMP28 | chr17:35454765 | chr17:34106327 | ENST00000250144 | 0 | 3 | 325_369 | 37 | 131.0 | Repeat | Note=Hemopexin 1 | |
| Tgene | MMP28 | chr17:35454765 | chr17:34106327 | ENST00000250144 | 0 | 3 | 370_409 | 37 | 131.0 | Repeat | Note=Hemopexin 2 | |
| Tgene | MMP28 | chr17:35454765 | chr17:34106327 | ENST00000250144 | 0 | 3 | 415_463 | 37 | 131.0 | Repeat | Note=Hemopexin 3 | |
| Tgene | MMP28 | chr17:35454765 | chr17:34106327 | ENST00000250144 | 0 | 3 | 464_510 | 37 | 131.0 | Repeat | Note=Hemopexin 4 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000335166 | - | 52 | 55 | 1918_2234 | 2125 | 2269.0 | Domain | CoA carboxyltransferase C-terminal |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000360679 | - | 51 | 54 | 1918_2234 | 2145 | 2289.0 | Domain | CoA carboxyltransferase C-terminal |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000394406 | - | 53 | 56 | 1918_2234 | 2203 | 2347.0 | Domain | CoA carboxyltransferase C-terminal |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000335166 | - | 52 | 55 | 1576_2234 | 2125 | 2269.0 | Region | Carboxyltransferase |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000360679 | - | 51 | 54 | 1576_2234 | 2145 | 2289.0 | Region | Carboxyltransferase |
| Hgene | ACACA | chr17:35454765 | chr17:34106327 | ENST00000394406 | - | 53 | 56 | 1576_2234 | 2203 | 2347.0 | Region | Carboxyltransferase |
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Fusion Gene Sequence for ACACA-MMP28 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >1165_1165_1_ACACA-MMP28_ACACA_chr17_35454765_ENST00000353139_MMP28_chr17_34106327_ENST00000250144_length(transcript)=7853nt_BP=7202nt GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGGTCTTTCTGGAAGTGGATAT CTACTCAGACAGTAAGAATTATAAGAGCTGTAAGAGCTCATTTTGGAGGAATAATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGC TGAACCAGCACTCTCGATTCATAATAGGTTCTGTGTCTGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGTTGGACCTACTGG AGGAGAAGGAGGGCTCCTTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCTGATTTGGGGATCTCTAGCCTACAGGATGGCTTGGCCT TGCACATAAGGTCCAGCATGTCTGGCTTGCACCTAGTAAAGCAGGGCCGAGACAGAAAGAAAATAGATTCTCAACGAGATTTCACTGTGG CTTCTCCAGCAGAATTTGTTACTCGCTTTGGGGGAAATAAAGTGATTGAGAAGGTTCTTATTGCTAACAATGGCATTGCAGCAGTGAAAT GCATGCGGTCTATCCGTAGGTGGTCTTATGAAATGTTTCGAAATGAACGTGCAATTAGATTCGTTGTCATGGTCACACCTGAAGACCTTA AAGCCAATGCAGAATACATTAAGATGGCAGATCACTATGTGCCAGTGCCTGGAGGACCAAACAACAACAACTATGCAAATGTGGAATTAA TTCTTGATATTGCTAAAAGGATCCCAGTACAAGCAGTGTGGGCTGGCTGGGGTCATGCTTCTGAGAATCCCAAACTACCGGAACTTCTCT TGAAAAATGGCATTGCCTTCATGGGTCCTCCAAGCCAGGCCATGTGGGCTTTAGGGGATAAGATTGCATCTTCCATAGTGGCTCAAACTG CAGGTATCCCAACTCTTCCCTGGAGCGGCAGTGGTCTTCGTGTGGACTGGCAGGAAAATGATTTTTCAAAACGTATCTTAAATGTTCCCC AGGAGCTATATGAAAAAGGTTATGTGAAAGATGTGGATGATGGGCTACAGGCAGCTGAGGAAGTTGGATATCCAGTAATGATCAAGGCCT CAGAGGGAGGAGGAGGGAAGGGAATTAGAAAAGTCAACAATGCAGATGACTTCCCTAATCTCTTCAGACAGGTTCAAGCTGAAGTTCCTG GATCTCCCATATTTGTGATGAGACTAGCCAAACAATCTCGTCATCTGGAGGTGCAGATCTTAGCGGACCAATATGGCAATGCTATCTCTT TGTTTGGTCGTGATTGCTCTGTACAACGCAGGCATCAGAAGATTATTGAAGAAGCACCTGCTACTATTGCTACTCCAGCAGTATTTGAAC ACATGGAACAGTGTGCGGTGAAACTTGCCAAAATGGTGGGTTATGTGAGTGCTGGGACTGTGGAATACCTGTACAGCCAGGATGGCAGCT TCTACTTTCTGGAATTGAATCCTCGGCTGCAGGTAGAGCACCCTTGTACAGAGATGGTGGCTGATGTCAATCTCCCTGCAGCACAGCTCC AGATTGCCATGGGGATTCCTCTATATAGAATCAAGGATATCCGTATGATGTATGGGGTATCTCCCTGGGGTGATTCTCCCATTGATTTTG AAGATTCTGCACACGTTCCTTGTCCAAGGGGCCATGTTATTGCTGCTCGGATCACTAGTGAAAATCCAGATGAGGGTTTTAAGCCCAGCT CAGGAACAGTTCAGGAGCTAAATTTCCGCAGCAATAAGAATGTTTGGGGATATTTCAGTGTTGCTGCTGCAGGGGGACTTCATGAATTTG CTGATTCTCAGTTTGGTCACTGCTTTTCTTGGGGAGAAAACAGAGAAGAGGCAATTTCAAACATGGTGGTGGCTTTGAAGGAGCTGTCTA TTCGGGGTGACTTTCGAACTACAGTTGAATACCTGATCAAATTGTTAGAGACTGAAAGCTTTCAGATGAACAGAATTGATACTGGCTGGC TGGACAGACTGATAGCAGAAAAAGTACAGGCTGAGCGACCTGACACCATGTTGGGGGTTGTGTGTGGTGCCCTCCACGTGGCAGATGTGA GCCTGCGGAATAGCGTCTCTAACTTCCTTCACTCCTTAGAAAGGGGTCAAGTCCTTCCTGCTCATACACTTCTGAATACAGTAGATGTTG AACTTATCTATGAGGGAGTCAAGTATGTACTTAAGGTGACTCGACAGTCCCCCAACTCCTATGTGGTGATCATGAATGGCTCATGTGTAG AAGTAGATGTACATCGGCTGAGTGACGGTGGACTGCTCTTGTCCTATGATGGCAGCAGTTATACTACGTATATGAAAGAGGAAGTGGATA GATATCGCATCACAATTGGCAATAAAACCTGTGTGTTTGAGAAGGAAAATGACCCATCGGTGATGCGCTCACCTTCTGCTGGGAAGTTAA TCCAGTACATTGTAGAAGATGGAGGTCATGTGTTTGCCGGCCAGTGCTATGCTGAGATTGAGGTAATGAAGATGGTAATGACCTTAACAG CTGTGGAGTCTGGCTGTATCCATTACGTCAAGCGACCTGGAGCAGCTCTTGACCCTGGCTGTGTACTAGCCAAAATGCAACTGGACAACC CCAGCAAGGTTCAGCAGGCTGAACTTCACACAGGTAGTCTGCCACGGATCCAGAGCACGGCACTCAGAGGCGAGAAACTCCATCGAGTGT TCCATTATGTCCTGGATAATCTGGTCAATGTAATGAATGGATACTGCCTTCCAGATCCTTTCTTTAGCAGCAAGGTAAAAGACTGGGTAG AGCGATTGATGAAAACCCTCAGAGATCCCTCCCTGCCTCTCCTAGAATTGCAAGATATTATGACCAGTGTGTCTGGCCGCATTCCCCCCA ATGTGGAGAAGTCTATCAAGAAGGAAATGGCTCAGTATGCTAGCAACATCACATCAGTCCTCTGTCAGTTTCCCAGCCAGCAGATTGCAA ACATCCTAGATAGCCATGCAGCTACATTGAACCGGAAATCTGAACGGGAAGTCTTCTTTATGAATACTCAGAGCATTGTTCAGCTGGTAC AGAGGTACCGAAGTGGCATCCGAGGCCACATGAAGGCTGTGGTGATGGATCTGCTCCGGCAGTACCTGCGAGTAGAGACACAATTCCAGA ATGGTCACTATGACAAATGTGTATTCGCCCTCCGAGAAGAGAATAAAAGTGACATGAACACTGTACTGAACTACATCTTCTCTCACGCTC AAGTCACCAAGAAGAATCTTCTGGTCACAATGCTTATTGATCAGTTGTGTGGCCGGGACCCTACTCTCACTGATGAGCTGCTGAATATTC TCACAGAGCTAACTCAACTCAGTAAGACCACCAATGCCAAAGTAGCACTTCGAGCACGCCAGGTTCTTATTGCCTCCCATTTGCCATCAT ATGAGCTTCGCCATAACCAAGTAGAGTCTATCTTCCTATCAGCTATTGACATGTATGGACATCAATTTTGCATTGAGAACCTGCAGAAAC TCATCCTATCAGAAACATCTATTTTTGATGTCCTACCAAACTTCTTCTATCACAGCAACCAAGTAGTGAGGATGGCAGCTCTGGAGGTGT ATGTTCGAAGGGCTTATATTGCCTATGAACTTAACAGCGTACAACACCGCCAGCTTAAGGACAACACCTGTGTGGTGGAATTCCAGTTCA TGCTGCCCACATCTCATCCAAACAGAGGGAACATCCCTACGCTAAACAGAATGTCCTTCTCCTCCAACCTCAACCACTATGGCATGACCC ATGTAGCTAGTGTCAGCGATGTACTGTTGGACAACTCATTCACTCCACCTTGTCAGCGGATGGGCGGAATGGTCTCTTTTCGGACTTTTG AAGATTTTGTCAGGATCTTTGATGAAGTGATGGGCTGCTTCTCTGACTCCCCACCCCAGAGTCCCACATTCCCTGAGGCAGGTCACACGT CTCTTTATGATGAGGATAAGGTTCCCAGGGATGAACCAATTCACATTCTCAATGTGGCTATCAAGACTGACTGTGATATTGAGGATGACA GGCTGGCAGCTATGTTCAGAGAATTTACCCAGCAAAATAAAGCTACCCTGGTTGACCATGGGATCCGGCGCCTTACTTTCCTGGTTGCAC AAAAGGATTTCAGAAAGCAGGTCAACTATGAGGTGGATCGGAGATTTCATAGAGAATTCCCTAAATTTTTTACATTCCGAGCAAGGGATA AGTTTGAGGAGGATCGTATCTATCGTCATCTGGAGCCTGCTCTGGCTTTCCAGTTAGAGCTGAACCGGATGAGAAATTTTGACCTCACTG CCATTCCATGTGCTAATCACAAGATGCACCTGTATCTCGGGGCAGCCAAGGTGGAAGTGGGCACAGAAGTGACAGACTACAGGTTCTTTG TTCGTGCAATCATCAGGCATTCTGATCTGGTCACCAAGGAAGCTTCTTTTGAATATCTGCAAAATGAAGGGGAGCGGCTACTCCTGGAAG CCATGGATGAGTTGGAAGTTGCTTTTAACAATACAAATGTCCGCACTGACTGTAACCACATCTTCCTCAACTTTGTGCCCACGGTTATCA TGGACCCATCAAAGATTGAGGAATCCGTGCGGAGCATGGTAATGCGGTATGGAAGTCGCCTGTGGAAATTGCGCGTCCTCCAGGCAGAAC TGAAAATCAACATTCGCCTGACGCCAACTGGAAAAGCAATTCCCATCCGCCTCTTCCTGACAAACGAGTCTGGCTATTACTTGGATATCA GCCTATACAAGGAAGTGACTGACTCCAGGACAGCACAGATCATGTTTCAGGCATATGGAGACAAACAGGGACCACTGCATGGAATGTTAA TCAATACTCCATATGTGACCAAAGACCTGCTGCAATCAAAGAGGTTCCAGGCACAATCCTTAGGGACAACATACATATATGATATCCCAG AGATGTTTCGGCAGTCCCTGATCAAACTCTGGGAGTCTATGTCCACTCAAGCATTTCTTCCATCTCCCCCTCTGCCTTCTGACATGCTGA CTTACACTGAACTGGTACTGGATGATCAAGGTCAGCTGGTCCACATGAACAGGCTTCCAGGAGGAAATGAGATTGGCATGGTAGCTTGGA AAATGACCTTTAAAAGTCCTGAATATCCAGAAGGCCGAGATATCATTGTTATTGGCAATGACATCACATACCGAATTGGGTCCTTTGGGC CTCAAGAGGATTTGTTATTTCTCAGAGCTTCCGAACTTGCTAGGGCAGAAGGTATTCCACGCATCTATGTATCAGCCAACAGTGGAGCAA GAATCGGACTGGCAGAAGAAATTCGCCATATGTTTCATGTGGCCTGGGTAGATCCTGAGGATCCTTACAAGGGATACAGGTATTTATATC TGACTCCTCAAGATTATAAGAGAGTCAGTGCTCTCAACTCTGTCCATTGTGAACACGTGGAAGATGAAGGAGAATCCAGGTACAAGATAA CAGATATTATTGGGAAAGAAGAGGGAATTGGACCCGAGAACCTTCGAGGTTCTGGAATGATTGCTGGAGAATCCTCATTGGCCTATAATG AGATCATTACCATCAGCCTGGTGACGTGCCGGGCCATTGGGATTGGGGCTTACCTTGTCCGGCTGGGACAGAGAACCATCCAGGTTGAGA ATTCTCACTTAATTCTAACAGGAGCTGGAGCCCTCAACAAAGTCCTCGGGCGGGAAGTGTACACCTCCAATAACCAGCTGGGGGGCATCC AGATTATGCACAACAATGGGGTGACCCACTGCACTGTGTGTGATGACTTTGAAGGGGTTTTCACTGTCCTGCACTGGCTGTCTTACATGC CCAAGAGCGTGCACAGTTCAGTTCCTCTTCTGAACTCAAAGGATCCTATAGACAGAATCATCGAGTTTGTTCCCACAAAGACCCCATACG ATCCTCGATGGATGCTAGCAGGCCGTCCTCACCCAACCCAAAAAGGTCAGTGGTTGAGTGGCTTTTTTGACTATGGATCTTTCTCAGAGA TTATGCAGCCCTGGGCACAGACTGTGGTGGTTGGTAGAGCCAGGCTAGGAGGAATACCTGTGGGAGTTGTTGCTGTAGAAACCCGAACAG TAGAACTAAGTATCCCAGCTGATCCAGCAAACCTGGATTCTGAAGCCAAGATAATCCAGCAGGCTGGCCAGGTTTGGTTCCCAGATTCTG CGTTTAAGACATATCAGGCCATCAAGGACTTCAACCGGGAAGGGCTGCCTCTGATGGTCTTTGCCAACTGGAGAGGCTTCTCTGGTGGAA TGAAAGATATGTACGACCAAGTGCTGAAGTTTGGTGCTTACATTGTGGATGGCTTGAGGGAGTGCTGCCAGCCTGTGCTGGTTTACATTC CTCCCCAGGCTGAGCTGCGGGGTGGCTCCTGGGTGGTGATTGACTCCTCCATCAACCCCCGGCACATGGAGATGTATGCTGACCGAGAAA GCAGGGGATCTGTTCTGGAGCCAGAAGGGACAGTAGAAATCAAATTCCGCAGAAAGGATCTGGTGAAAACCATGCGTCGGGTGGACCCAG TCTACATCCACTTGGCTGAGCGATTGGGGACCCCAGAGCTAAGCACAGCTGAGCGGAAGGAGTTGGAGAACAAGTTGAAGGAGCGGGAGG AATTCCTAATTCCCATTTACCATCAGGTAGCCGTGCAGTTTGCTGACTTGCACGACACACCAGGCCGGATGCAGGAGAAGGGTGTTATTA GCGCATTCCTAGAGAAGTACGGATACCTCAATGAACAGGTCCCCAAAGCTCCCACCTCCACTCGATTCAGCGATGCCATCAGAGCGTTTC AGTGGGTGTCCCAGCTACCTGTCAGCGGCGTGTTGGACCGCGCCACCCTGCGCCAGATGACTCGTCCCCGCTGCGGGGTTACAGATACCA ACAGTTATGCGGCCTGGGCTGAGAGGATCAGTGACTTGTTTGCTAGACACCGGACCAAAATGAGGCGTAAGAAACGCTTTGCAAAGCAAG GTGAGCACTGTTAAAATCCGGCTAGGCCAAGATTTCCCAATGTCTTGAAGCCAATGGCTAGGAAAACAGCTGAGCCTGGGACTGGACTTT GTCAGTAACCTCTCTTCCCTAGGGCACGGGAGGAGTGGGTGAATAGGACCTCTTGGCTTGAGGACCATGATTGTGAATACAGACATTTAA TTCAGAATGACACCTACATTGATGAATTTTCATTGTACAAGTGTTTTTCCAGATCAAACACAAAACCCATGTAATTCCTTGATAAATTTT CAATGCAGGGCAGATAAACTGTTGCTAACATTTTTCATTTATATTTACTGAAGTTATTTTCATCAGAATTCATTCTTTTTCATAAGTTAT >1165_1165_1_ACACA-MMP28_ACACA_chr17_35454765_ENST00000353139_MMP28_chr17_34106327_ENST00000250144_length(amino acids)=2340AA_BP=2247 MRRNDERMWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKE GSLSPASVGSDTLSDLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRS IRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNG IAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGG GGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQ CAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSA HVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGD FRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRNSVSNFLHSLERGQVLPAHTLLNTVDVELIY EGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYI VEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRIQSTALRGEKLHRVFHYV LDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILD SHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQVTK KNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILS ETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVAS VSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSPPQSPTFPEAGHTSLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAA MFREFTQQNKATLVDHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPC ANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPS KIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTP YVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTF KSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGARIGLAEEIRHMFHVAWVDPEDPYKGYRYLYLTPQ DYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYNEIITISLVTCRAIGIGAYLVRLGQRTIQVENSHL ILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRW MLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKT YQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVVIDSSINPRHMEMYADRESRGS VLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVISAFL EKYGYLNEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGEHC -------------------------------------------------------------- >1165_1165_2_ACACA-MMP28_ACACA_chr17_35454765_ENST00000360679_MMP28_chr17_34106327_ENST00000250144_length(transcript)=7521nt_BP=6870nt GGCAGCCAGGAGAGGCAGTGGAGCTTTTCTCCGTTGACTGTCAGAAGAAAGTGACTGTTGTTGAAAATGTTTGCTGCAACTAAAGGAGAG CTGCTAAGATCTACTTTCTAGTTAAACAAGCTTTTATATTTCTCCCCGGCTCCTCTCAGTTCCCTTGGGAAATCAACTAATTGTGTGTGT AAGCTAAGTGTGTGGAGGAGAGAAGATGCAAAAAGGAAGAGAAAGGTGGGGAAAGAAGGAAATTGGGAACAATTAGACAAAAAGACTATA GTTTGAGGCCATCAGGAGTATTCTAGTCTGACTGAAGCCAGGCAGAAGGCACAGTATCTCTTGTCCTCCTGGGTTTTAAGCAGCTGCAAC AGGAGGAGGAACTGCGGCTTGTGTTTACAAGGCCGAAATCTGAAGAAAAAGCTTCCATTCTTTTCCCATCTTGATATGGAGGGTTCTCCA GAGGAAAATAAGGAAATGAGATATTACATGCTTCAAAGGTCCAGCATGTCTGGCTTGCACCTAGTAAAGCAGGGCCGAGACAGAAAGAAA ATAGATTCTCAACGAGATTTCACTGTGGCTTCTCCAGCAGAATTTGTTACTCGCTTTGGGGGAAATAAAGTGATTGAGAAGGTTCTTATT GCTAACAATGGCATTGCAGCAGTGAAATGCATGCGGTCTATCCGTAGGTGGTCTTATGAAATGTTTCGAAATGAACGTGCAATTAGATTC GTTGTCATGGTCACACCTGAAGACCTTAAAGCCAATGCAGAATACATTAAGATGGCAGATCACTATGTGCCAGTGCCTGGAGGACCAAAC AACAACAACTATGCAAATGTGGAATTAATTCTTGATATTGCTAAAAGGATCCCAGTACAAGCAGTGTGGGCTGGCTGGGGTCATGCTTCT GAGAATCCCAAACTACCGGAACTTCTCTTGAAAAATGGCATTGCCTTCATGGGTCCTCCAAGCCAGGCCATGTGGGCTTTAGGGGATAAG ATTGCATCTTCCATAGTGGCTCAAACTGCAGGTATCCCAACTCTTCCCTGGAGCGGCAGTGGTCTTCGTGTGGACTGGCAGGAAAATGAT TTTTCAAAACGTATCTTAAATGTTCCCCAGGAGCTATATGAAAAAGGTTATGTGAAAGATGTGGATGATGGGCTACAGGCAGCTGAGGAA GTTGGATATCCAGTAATGATCAAGGCCTCAGAGGGAGGAGGAGGGAAGGGAATTAGAAAAGTCAACAATGCAGATGACTTCCCTAATCTC TTCAGACAGGTTCAAGCTGAAGTTCCTGGATCTCCCATATTTGTGATGAGACTAGCCAAACAATCTCGTCATCTGGAGGTGCAGATCTTA GCGGACCAATATGGCAATGCTATCTCTTTGTTTGGTCGTGATTGCTCTGTACAACGCAGGCATCAGAAGATTATTGAAGAAGCACCTGCT ACTATTGCTACTCCAGCAGTATTTGAACACATGGAACAGTGTGCGGTGAAACTTGCCAAAATGGTGGGTTATGTGAGTGCTGGGACTGTG GAATACCTGTACAGCCAGGATGGCAGCTTCTACTTTCTGGAATTGAATCCTCGGCTGCAGGTAGAGCACCCTTGTACAGAGATGGTGGCT GATGTCAATCTCCCTGCAGCACAGCTCCAGATTGCCATGGGGATTCCTCTATATAGAATCAAGGATATCCGTATGATGTATGGGGTATCT CCCTGGGGTGATTCTCCCATTGATTTTGAAGATTCTGCACACGTTCCTTGTCCAAGGGGCCATGTTATTGCTGCTCGGATCACTAGTGAA AATCCAGATGAGGGTTTTAAGCCCAGCTCAGGAACAGTTCAGGAGCTAAATTTCCGCAGCAATAAGAATGTTTGGGGATATTTCAGTGTT GCTGCTGCAGGGGGACTTCATGAATTTGCTGATTCTCAGTTTGGTCACTGCTTTTCTTGGGGAGAAAACAGAGAAGAGGCAATTTCAAAC ATGGTGGTGGCTTTGAAGGAGCTGTCTATTCGGGGTGACTTTCGAACTACAGTTGAATACCTGATCAAATTGTTAGAGACTGAAAGCTTT CAGATGAACAGAATTGATACTGGCTGGCTGGACAGACTGATAGCAGAAAAAGTACAGGCTGAGCGACCTGACACCATGTTGGGGGTTGTG TGTGGTGCCCTCCACGTGGCAGATGTGAGCCTGCGGAATAGCGTCTCTAACTTCCTTCACTCCTTAGAAAGGGGTCAAGTCCTTCCTGCT CATACACTTCTGAATACAGTAGATGTTGAACTTATCTATGAGGGAGTCAAGTATGTACTTAAGGTGACTCGACAGTCCCCCAACTCCTAT GTGGTGATCATGAATGGCTCATGTGTAGAAGTAGATGTACATCGGCTGAGTGACGGTGGACTGCTCTTGTCCTATGATGGCAGCAGTTAT ACTACGTATATGAAAGAGGAAGTGGATAGATATCGCATCACAATTGGCAATAAAACCTGTGTGTTTGAGAAGGAAAATGACCCATCGGTG ATGCGCTCACCTTCTGCTGGGAAGTTAATCCAGTACATTGTAGAAGATGGAGGTCATGTGTTTGCCGGCCAGTGCTATGCTGAGATTGAG GTAATGAAGATGGTAATGACCTTAACAGCTGTGGAGTCTGGCTGTATCCATTACGTCAAGCGACCTGGAGCAGCTCTTGACCCTGGCTGT GTACTAGCCAAAATGCAACTGGACAACCCCAGCAAGGTTCAGCAGGCTGAACTTCACACAGGTAGTCTGCCACGGATCCAGAGCACGGCA CTCAGAGGCGAGAAACTCCATCGAGTGTTCCATTATGTCCTGGATAATCTGGTCAATGTAATGAATGGATACTGCCTTCCAGATCCTTTC TTTAGCAGCAAGGTAAAAGACTGGGTAGAGCGATTGATGAAAACCCTCAGAGATCCCTCCCTGCCTCTCCTAGAATTGCAAGATATTATG ACCAGTGTGTCTGGCCGCATTCCCCCCAATGTGGAGAAGTCTATCAAGAAGGAAATGGCTCAGTATGCTAGCAACATCACATCAGTCCTC TGTCAGTTTCCCAGCCAGCAGATTGCAAACATCCTAGATAGCCATGCAGCTACATTGAACCGGAAATCTGAACGGGAAGTCTTCTTTATG AATACTCAGAGCATTGTTCAGCTGGTACAGAGGTACCGAAGTGGCATCCGAGGCCACATGAAGGCTGTGGTGATGGATCTGCTCCGGCAG TACCTGCGAGTAGAGACACAATTCCAGAATGGTCACTATGACAAATGTGTATTCGCCCTCCGAGAAGAGAATAAAAGTGACATGAACACT GTACTGAACTACATCTTCTCTCACGCTCAAGTCACCAAGAAGAATCTTCTGGTCACAATGCTTATTGATCAGTTGTGTGGCCGGGACCCT ACTCTCACTGATGAGCTGCTGAATATTCTCACAGAGCTAACTCAACTCAGTAAGACCACCAATGCCAAAGTAGCACTTCGAGCACGCCAG GTTCTTATTGCCTCCCATTTGCCATCATATGAGCTTCGCCATAACCAAGTAGAGTCTATCTTCCTATCAGCTATTGACATGTATGGACAT CAATTTTGCATTGAGAACCTGCAGAAACTCATCCTATCAGAAACATCTATTTTTGATGTCCTACCAAACTTCTTCTATCACAGCAACCAA GTAGTGAGGATGGCAGCTCTGGAGGTGTATGTTCGAAGGGCTTATATTGCCTATGAACTTAACAGCGTACAACACCGCCAGCTTAAGGAC AACACCTGTGTGGTGGAATTCCAGTTCATGCTGCCCACATCTCATCCAAACAGAGGGAACATCCCTACGCTAAACAGAATGTCCTTCTCC TCCAACCTCAACCACTATGGCATGACCCATGTAGCTAGTGTCAGCGATGTACTGTTGGACAACTCATTCACTCCACCTTGTCAGCGGATG GGCGGAATGGTCTCTTTTCGGACTTTTGAAGATTTTGTCAGGATCTTTGATGAAGTGATGGGCTGCTTCTCTGACTCCCCACCCCAGAGT CCCACATTCCCTGAGGCAGGTCACACGTCTCTTTATGATGAGGATAAGGTTCCCAGGGATGAACCAATTCACATTCTCAATGTGGCTATC AAGACTGACTGTGATATTGAGGATGACAGGCTGGCAGCTATGTTCAGAGAATTTACCCAGCAAAATAAAGCTACCCTGGTTGACCATGGG ATCCGGCGCCTTACTTTCCTGGTTGCACAAAAGGATTTCAGAAAGCAGGTCAACTATGAGGTGGATCGGAGATTTCATAGAGAATTCCCT AAATTTTTTACATTCCGAGCAAGGGATAAGTTTGAGGAGGATCGTATCTATCGTCATCTGGAGCCTGCTCTGGCTTTCCAGTTAGAGCTG AACCGGATGAGAAATTTTGACCTCACTGCCATTCCATGTGCTAATCACAAGATGCACCTGTATCTCGGGGCAGCCAAGGTGGAAGTGGGC ACAGAAGTGACAGACTACAGGTTCTTTGTTCGTGCAATCATCAGGCATTCTGATCTGGTCACCAAGGAAGCTTCTTTTGAATATCTGCAA AATGAAGGGGAGCGGCTACTCCTGGAAGCCATGGATGAGTTGGAAGTTGCTTTTAACAATACAAATGTCCGCACTGACTGTAACCACATC TTCCTCAACTTTGTGCCCACGGTTATCATGGACCCATCAAAGATTGAGGAATCCGTGCGGAGCATGGTAATGCGGTATGGAAGTCGCCTG TGGAAATTGCGCGTCCTCCAGGCAGAACTGAAAATCAACATTCGCCTGACGCCAACTGGAAAAGCAATTCCCATCCGCCTCTTCCTGACA AACGAGTCTGGCTATTACTTGGATATCAGCCTATACAAGGAAGTGACTGACTCCAGGACAGCACAGATCATGTTTCAGGCATATGGAGAC AAACAGGGACCACTGCATGGAATGTTAATCAATACTCCATATGTGACCAAAGACCTGCTGCAATCAAAGAGGTTCCAGGCACAATCCTTA GGGACAACATACATATATGATATCCCAGAGATGTTTCGGCAGTCCCTGATCAAACTCTGGGAGTCTATGTCCACTCAAGCATTTCTTCCA TCTCCCCCTCTGCCTTCTGACATGCTGACTTACACTGAACTGGTACTGGATGATCAAGGTCAGCTGGTCCACATGAACAGGCTTCCAGGA GGAAATGAGATTGGCATGGTAGCTTGGAAAATGACCTTTAAAAGTCCTGAATATCCAGAAGGCCGAGATATCATTGTTATTGGCAATGAC ATCACATACCGAATTGGGTCCTTTGGGCCTCAAGAGGATTTGTTATTTCTCAGAGCTTCCGAACTTGCTAGGGCAGAAGGTATTCCACGC ATCTATGTATCAGCCAACAGTGGAGCAAGAATCGGACTGGCAGAAGAAATTCGCCATATGTTTCATGTGGCCTGGGTAGATCCTGAGGAT CCTTACAAGGGATACAGGTATTTATATCTGACTCCTCAAGATTATAAGAGAGTCAGTGCTCTCAACTCTGTCCATTGTGAACACGTGGAA GATGAAGGAGAATCCAGGTACAAGATAACAGATATTATTGGGAAAGAAGAGGGAATTGGACCCGAGAACCTTCGAGGTTCTGGAATGATT GCTGGAGAATCCTCATTGGCCTATAATGAGATCATTACCATCAGCCTGGTGACGTGCCGGGCCATTGGGATTGGGGCTTACCTTGTCCGG CTGGGACAGAGAACCATCCAGGTTGAGAATTCTCACTTAATTCTAACAGGAGCTGGAGCCCTCAACAAAGTCCTCGGGCGGGAAGTGTAC ACCTCCAATAACCAGCTGGGGGGCATCCAGATTATGCACAACAATGGGGTGACCCACTGCACTGTGTGTGATGACTTTGAAGGGGTTTTC ACTGTCCTGCACTGGCTGTCTTACATGCCCAAGAGCGTGCACAGTTCAGTTCCTCTTCTGAACTCAAAGGATCCTATAGACAGAATCATC GAGTTTGTTCCCACAAAGACCCCATACGATCCTCGATGGATGCTAGCAGGCCGTCCTCACCCAACCCAAAAAGGTCAGTGGTTGAGTGGC TTTTTTGACTATGGATCTTTCTCAGAGATTATGCAGCCCTGGGCACAGACTGTGGTGGTTGGTAGAGCCAGGCTAGGAGGAATACCTGTG GGAGTTGTTGCTGTAGAAACCCGAACAGTAGAACTAAGTATCCCAGCTGATCCAGCAAACCTGGATTCTGAAGCCAAGATAATCCAGCAG GCTGGCCAGGTTTGGTTCCCAGATTCTGCGTTTAAGACATATCAGGCCATCAAGGACTTCAACCGGGAAGGGCTGCCTCTGATGGTCTTT GCCAACTGGAGAGGCTTCTCTGGTGGAATGAAAGATATGTACGACCAAGTGCTGAAGTTTGGTGCTTACATTGTGGATGGCTTGAGGGAG TGCTGCCAGCCTGTGCTGGTTTACATTCCTCCCCAGGCTGAGCTGCGGGGTGGCTCCTGGGTGGTGATTGACTCCTCCATCAACCCCCGG CACATGGAGATGTATGCTGACCGAGAAAGCAGGGGATCTGTTCTGGAGCCAGAAGGGACAGTAGAAATCAAATTCCGCAGAAAGGATCTG GTGAAAACCATGCGTCGGGTGGACCCAGTCTACATCCACTTGGCTGAGCGATTGGGGACCCCAGAGCTAAGCACAGCTGAGCGGAAGGAG TTGGAGAACAAGTTGAAGGAGCGGGAGGAATTCCTAATTCCCATTTACCATCAGGTAGCCGTGCAGTTTGCTGACTTGCACGACACACCA GGCCGGATGCAGGAGAAGGGTGTTATTAGCGCATTCCTAGAGAAGTACGGATACCTCAATGAACAGGTCCCCAAAGCTCCCACCTCCACT CGATTCAGCGATGCCATCAGAGCGTTTCAGTGGGTGTCCCAGCTACCTGTCAGCGGCGTGTTGGACCGCGCCACCCTGCGCCAGATGACT CGTCCCCGCTGCGGGGTTACAGATACCAACAGTTATGCGGCCTGGGCTGAGAGGATCAGTGACTTGTTTGCTAGACACCGGACCAAAATG AGGCGTAAGAAACGCTTTGCAAAGCAAGGTGAGCACTGTTAAAATCCGGCTAGGCCAAGATTTCCCAATGTCTTGAAGCCAATGGCTAGG AAAACAGCTGAGCCTGGGACTGGACTTTGTCAGTAACCTCTCTTCCCTAGGGCACGGGAGGAGTGGGTGAATAGGACCTCTTGGCTTGAG GACCATGATTGTGAATACAGACATTTAATTCAGAATGACACCTACATTGATGAATTTTCATTGTACAAGTGTTTTTCCAGATCAAACACA AAACCCATGTAATTCCTTGATAAATTTTCAATGCAGGGCAGATAAACTGTTGCTAACATTTTTCATTTATATTTACTGAAGTTATTTTCA >1165_1165_2_ACACA-MMP28_ACACA_chr17_35454765_ENST00000360679_MMP28_chr17_34106327_ENST00000250144_length(amino acids)=2284AA_BP=2191 MTEARQKAQYLLSSWVLSSCNRRRNCGLCLQGRNLKKKLPFFSHLDMEGSPEENKEMRYYMLQRSSMSGLHLVKQGRDRKKIDSQRDFTV ASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVEL ILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVP QELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAIS LFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQL QIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEF ADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADV SLRNSVSNFLHSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVD RYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDN PSKVQQAELHTGSLPRIQSTALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPP NVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQ NGHYDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPS YELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQF MLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVASVSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSPPQSPTFPEAGHT SLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLVDHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARD KFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLE AMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDI SLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDML TYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGA RIGLAEEIRHMFHVAWVDPEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYN EIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYM PKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRT VELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYI PPQAELRGGSWVVIDSSINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKERE EFLIPIYHQVAVQFADLHDTPGRMQEKGVISAFLEKYGYLNEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDT -------------------------------------------------------------- >1165_1165_3_ACACA-MMP28_ACACA_chr17_35454765_ENST00000361253_MMP28_chr17_34106327_ENST00000250144_length(transcript)=1956nt_BP=1305nt AGAAATTCGCCATATGTTTCATGTGGCCTGGGTAGATCCTGAGGATCCTTACAAGGGATACAGGTATTTATATCTGACTCCTCAAGATTA TAAGAGAGTCAGTGCTCTCAACTCTGTCCATTGTGAACACGTGGAAGATGAAGGAGAATCCAGGTGACGTGCCGGGCCATTGGGATTGGG GCTTACCTTGTCCGGCTGGGACAGAGAACCATCCAGGTTGAGAATTCTCACTTAATTCTAACAGGAGCTGGAGCCCTCAACAAAGTCCTC GGGCGGGAAGTGTACACCTCCAATAACCAGCTGGGGGGCATCCAGATTATGCACAACAATGGGGTGACCCACTGCACTGTGTGTGATGAC TTTGAAGGGGTTTTCACTGTCCTGCACTGGCTGTCTTACATGCCCAAGAGCGTGCACAGTTCAGTTCCTCTTCTGAACTCAAAGGATCCT ATAGACAGAATCATCGAGTTTGTTCCCACAAAGACCCCATACGATCCTCGATGGATGCTAGCAGGCCGTCCTCACCCAACCCAAAAAGGT CAGTGGTTGAGTGGCTTTTTTGACTATGGATCTTTCTCAGAGATTATGCAGCCCTGGGCACAGACTGTGGTGGTTGGTAGAGCCAGGCTA GGAGGAATACCTGTGGGAGTTGTTGCTGTAGAAACCCGAACAGTAGAACTAAGTATCCCAGCTGATCCAGCAAACCTGGATTCTGAAGCC AAGATAATCCAGCAGGCTGGCCAGGTTTGGTTCCCAGATTCTGCGTTTAAGACATATCAGGCCATCAAGGACTTCAACCGGGAAGGGCTG CCTCTGATGGTCTTTGCCAACTGGAGAGGCTTCTCTGGTGGAATGAAAGATATGTACGACCAAGTGCTGAAGTTTGGTGCTTACATTGTG GATGGCTTGAGGGAGTGCTGCCAGCCTGTGCTGGTTTACATTCCTCCCCAGGCTGAGCTGCGGGGTGGCTCCTGGGTGGTGATTGACTCC TCCATCAACCCCCGGCACATGGAGATGTATGCTGACCGAGAAAGCAGGGGATCTGTTCTGGAGCCAGAAGGGACAGTAGAAATCAAATTC CGCAGAAAGGATCTGGTGAAAACCATGCGTCGGGTGGACCCAGTCTACATCCACTTGGCTGAGCGATTGGGGACCCCAGAGCTAAGCACA GCTGAGCGGAAGGAGTTGGAGAACAAGTTGAAGGAGCGGGAGGAATTCCTAATTCCCATTTACCATCAGGTAGCCGTGCAGTTTGCTGAC TTGCACGACACACCAGGCCGGATGCAGGAGAAGGGTGTTATTAGCGCATTCCTAGAGAAGTACGGATACCTCAATGAACAGGTCCCCAAA GCTCCCACCTCCACTCGATTCAGCGATGCCATCAGAGCGTTTCAGTGGGTGTCCCAGCTACCTGTCAGCGGCGTGTTGGACCGCGCCACC CTGCGCCAGATGACTCGTCCCCGCTGCGGGGTTACAGATACCAACAGTTATGCGGCCTGGGCTGAGAGGATCAGTGACTTGTTTGCTAGA CACCGGACCAAAATGAGGCGTAAGAAACGCTTTGCAAAGCAAGGTGAGCACTGTTAAAATCCGGCTAGGCCAAGATTTCCCAATGTCTTG AAGCCAATGGCTAGGAAAACAGCTGAGCCTGGGACTGGACTTTGTCAGTAACCTCTCTTCCCTAGGGCACGGGAGGAGTGGGTGAATAGG ACCTCTTGGCTTGAGGACCATGATTGTGAATACAGACATTTAATTCAGAATGACACCTACATTGATGAATTTTCATTGTACAAGTGTTTT TCCAGATCAAACACAAAACCCATGTAATTCCTTGATAAATTTTCAATGCAGGGCAGATAAACTGTTGCTAACATTTTTCATTTATATTTA >1165_1165_3_ACACA-MMP28_ACACA_chr17_35454765_ENST00000361253_MMP28_chr17_34106327_ENST00000250144_length(amino acids)=463AA_BP=370 MGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKDPIDRII EFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRTVELSIPADPANLDSEAKIIQQ AGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVVIDSSINPR HMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKEREEFLIPIYHQVAVQFADLHDTP GRMQEKGVISAFLEKYGYLNEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKM -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ACACA-MMP28 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACACA-MMP28 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ACACA-MMP28 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ACACA | C0018801 | Heart failure | 1 | CTD_human |
| Hgene | ACACA | C0018802 | Congestive heart failure | 1 | CTD_human |
| Hgene | ACACA | C0023212 | Left-Sided Heart Failure | 1 | CTD_human |
| Hgene | ACACA | C0235527 | Heart Failure, Right-Sided | 1 | CTD_human |
| Hgene | ACACA | C1959583 | Myocardial Failure | 1 | CTD_human |
| Hgene | ACACA | C1961112 | Heart Decompensation | 1 | CTD_human |
| Hgene | ACACA | C2239176 | Liver carcinoma | 1 | CTD_human |
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