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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACACA-FAM104A (FusionGDB2 ID:HG31TG84923)

Fusion Gene Summary for ACACA-FAM104A

check button Fusion gene summary
Fusion gene informationFusion gene name: ACACA-FAM104A
Fusion gene ID: hg31tg84923
HgeneTgene
Gene symbol

ACACA

FAM104A

Gene ID

31

84923

Gene nameacetyl-CoA carboxylase alphafamily with sequence similarity 104 member A
SynonymsACAC|ACACAD|ACC|ACC1|ACCA-
Cytomap('ACACA')('FAM104A')

17q12

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionacetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alphaprotein FAM104A
Modification date2020031320200313
UniProtAcc.

Q969W3

Ensembl transtripts involved in fusion geneENST00000335166, ENST00000353139, 
ENST00000360679, ENST00000394406, 
ENST00000361253, ENST00000416895, 
ENST00000588142, ENST00000589665, 
Fusion gene scores* DoF score44 X 35 X 17=261805 X 18 X 9=810
# samples 5120
** MAII scorelog2(51/26180*10)=-5.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/810*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACACA [Title/Abstract] AND FAM104A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACACA(35631084)-FAM104A(71205907), # samples:2
Anticipated loss of major functional domain due to fusion event.ACACA-FAM104A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACACA-FAM104A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACACA-FAM104A seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ACACA-FAM104A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ACACA-FAM104A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ACACA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FAM104A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0DD-01AACACAchr17

35631084

-FAM104Achr17

71205907

-


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Fusion Gene ORF analysis for ACACA-FAM104A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000335166ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000335166ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000335166ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000335166ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000353139ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000353139ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000353139ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000353139ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000360679ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000360679ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000360679ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000360679ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000394406ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000394406ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000394406ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000394406ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
Frame-shiftENST00000335166ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
Frame-shiftENST00000335166ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
Frame-shiftENST00000353139ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
Frame-shiftENST00000360679ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
Frame-shiftENST00000394406ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
Frame-shiftENST00000394406ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
In-frameENST00000353139ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
In-frameENST00000360679ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000361253ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000361253ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000416895ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000416895ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000588142ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000588142ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000589665ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000589665ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000361253ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000361253ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000361253ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000361253ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000416895ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000416895ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000416895ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000416895ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000588142ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000588142ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000588142ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000588142ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000589665ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000589665ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000589665ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000589665ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000353139ACACAchr1735631084-ENST00000403627FAM104Achr1771205907-390614904611729422
ENST00000360679ACACAchr1735631084-ENST00000403627FAM104Achr1771205907-357411582971397366

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000353139ENST00000403627ACACAchr1735631084-FAM104Achr1771205907-0.0012053630.99879456
ENST00000360679ENST00000403627ACACAchr1735631084-FAM104Achr1771205907-0.0006052640.9993948

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Fusion Genomic Features for ACACA-FAM104A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ACACA-FAM104A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:35631084/chr17:71205907)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAM104A

Q969W3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACACAchr17:35631084chr17:71205907ENST00000353139-956315_3203362384.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACACAchr17:35631084chr17:71205907ENST00000335166-855117_6182212269.0DomainBiotin carboxylation
HgeneACACAchr17:35631084chr17:71205907ENST00000335166-8551576_19142212269.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000335166-8551918_22342212269.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000335166-855275_4662212269.0DomainATP-grasp
HgeneACACAchr17:35631084chr17:71205907ENST00000335166-855745_8192212269.0DomainBiotinyl-binding
HgeneACACAchr17:35631084chr17:71205907ENST00000353139-956117_6183362384.0DomainBiotin carboxylation
HgeneACACAchr17:35631084chr17:71205907ENST00000353139-9561576_19143362384.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000353139-9561918_22343362384.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000353139-956275_4663362384.0DomainATP-grasp
HgeneACACAchr17:35631084chr17:71205907ENST00000353139-956745_8193362384.0DomainBiotinyl-binding
HgeneACACAchr17:35631084chr17:71205907ENST00000360679-754117_6182412289.0DomainBiotin carboxylation
HgeneACACAchr17:35631084chr17:71205907ENST00000360679-7541576_19142412289.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000360679-7541918_22342412289.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000360679-754275_4662412289.0DomainATP-grasp
HgeneACACAchr17:35631084chr17:71205907ENST00000360679-754745_8192412289.0DomainBiotinyl-binding
HgeneACACAchr17:35631084chr17:71205907ENST00000394406-956117_6182992347.0DomainBiotin carboxylation
HgeneACACAchr17:35631084chr17:71205907ENST00000394406-9561576_19142992347.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000394406-9561918_22342992347.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000394406-956275_4662992347.0DomainATP-grasp
HgeneACACAchr17:35631084chr17:71205907ENST00000394406-956745_8192992347.0DomainBiotinyl-binding
HgeneACACAchr17:35631084chr17:71205907ENST00000335166-855315_3202212269.0Nucleotide bindingATP
HgeneACACAchr17:35631084chr17:71205907ENST00000360679-754315_3202412289.0Nucleotide bindingATP
HgeneACACAchr17:35631084chr17:71205907ENST00000394406-956315_3202992347.0Nucleotide bindingATP
HgeneACACAchr17:35631084chr17:71205907ENST00000335166-8551576_22342212269.0RegionCarboxyltransferase
HgeneACACAchr17:35631084chr17:71205907ENST00000353139-9561576_22343362384.0RegionCarboxyltransferase
HgeneACACAchr17:35631084chr17:71205907ENST00000360679-7541576_22342412289.0RegionCarboxyltransferase
HgeneACACAchr17:35631084chr17:71205907ENST00000394406-9561576_22342992347.0RegionCarboxyltransferase
TgeneFAM104Achr17:35631084chr17:71205907ENST000004036271394_145107187.0Compositional biasNote=Ser-rich
TgeneFAM104Achr17:35631084chr17:71205907ENST000004051592494_145128208.0Compositional biasNote=Ser-rich


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Fusion Gene Sequence for ACACA-FAM104A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1151_1151_1_ACACA-FAM104A_ACACA_chr17_35631084_ENST00000353139_FAM104A_chr17_71205907_ENST00000403627_length(transcript)=3906nt_BP=1490nt
GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG
ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC
CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG
GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT
TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC
AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGGTCTTTCTGGAAGTGGATAT
CTACTCAGACAGTAAGAATTATAAGAGCTGTAAGAGCTCATTTTGGAGGAATAATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGC
TGAACCAGCACTCTCGATTCATAATAGGTTCTGTGTCTGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGTTGGACCTACTGG
AGGAGAAGGAGGGCTCCTTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCTGATTTGGGGATCTCTAGCCTACAGGATGGCTTGGCCT
TGCACATAAGGTCCAGCATGTCTGGCTTGCACCTAGTAAAGCAGGGCCGAGACAGAAAGAAAATAGATTCTCAACGAGATTTCACTGTGG
CTTCTCCAGCAGAATTTGTTACTCGCTTTGGGGGAAATAAAGTGATTGAGAAGGTTCTTATTGCTAACAATGGCATTGCAGCAGTGAAAT
GCATGCGGTCTATCCGTAGGTGGTCTTATGAAATGTTTCGAAATGAACGTGCAATTAGATTCGTTGTCATGGTCACACCTGAAGACCTTA
AAGCCAATGCAGAATACATTAAGATGGCAGATCACTATGTGCCAGTGCCTGGAGGACCAAACAACAACAACTATGCAAATGTGGAATTAA
TTCTTGATATTGCTAAAAGGATCCCAGTACAAGCAGTGTGGGCTGGCTGGGGTCATGCTTCTGAGAATCCCAAACTACCGGAACTTCTCT
TGAAAAATGGCATTGCCTTCATGGGTCCTCCAAGCCAGGCCATGTGGGCTTTAGGGGATAAGATTGCATCTTCCATAGTGGCTCAAACTG
CAGGTATCCCAACTCTTCCCTGGAGCGGCAGTGGTCTTCGTGTGGACTGGCAGGAAAATGATTTTTCAAAACGTATCTTAAATGTTCCCC
AGGAGCTATATGAAAAAGGTTATGTGAAAGATGTGGATGATGGGCTACAGTCTTCAGGCAGTGACAGTGGTGGGAGCAGCAGCAGCAGCA
GCAGCAGCATCAATAGCCCGGACAGGGCCAGCGGGCCGGAAGGCAGCTTGAGCCAGACCATGGCCGGATCCAGCCCTAACACGCCTCAGC
CCGTGCCCGAGCAGTCCGCGCTGTGCCAAGGCCTCTACTTCCACATCAACCAGACCCTGAGGGAGGCCCACTTCCACAGCCTACAGCACC
GAGGGCGGCCTCTGACATGATGTGCCGGCAGTTTCTTGCCTTCTGTGAAGGGACAGCGCTGTGCAGATTTGATATTTCAACTTACAACTT
GTTTTAAAAGAAAAATTGCACACGAAAAATGCCTGTTGGCTTTTCAGTCTATATTTGAAATAACAGGTTAACAGGCAGTTGTTTACTTGT
GGTTTTGCTGCACTATTGCAATTTCAAAGGGGCTTTGAAGCAATTTTTTATAGGATTCTTTTGAGGGAGGGTATCAAATCTATGTCAAGG
TAGTGGTTTGAGGAAAACTCATTCTGTGTGTTGAATCCATAGTATGTCCCATTCAGACTGATTTCCAAATCTGTCAACTAGAAACTCTAC
TTTATGTAAAGGGCCTTTTAAAAATGCGGGATCTTCAATTTTTTTTATTCAATAAACTAGTAAAGAGTATCTAGTTTCCATGAAAAAACA
TAAGTTTTTTTCCAAAATATAGGAAGCTTGATTCAGTCTTGCACTGAAATTAACTGCCATACTACCTCTCAGTATGTAGATGTTCTATTG
AAAGTACTCTCTCCTGTGTAACAGGAGAACAATCAGATCCAATTCAGACTGTCAGTGAAGCACACTCCCTAATAATAGTCTCTACTCTTT
GTTATATATTTGTATTTCCAGAGAGAATGTCTTTTAGATTCTTGTATACCCAGATAACTTCTGTGTCACTATTCCACCAGAGTCTGCACC
TCAGACTTTAGTAGGAAACATGGCACAGTTCTGCAAGTAAAGTAATATGTAATGACTTTTTGTCCTACAAACTTGGTCAGTCAGCAGCTT
ACATGATCTCATTGACAATTCCACCTTGTAGTGTCAACAATTAAGGTGTTGTTGAACGCTGATAAAATGTAAGCTACCTGAACTGATGTC
TAAAGCAACAAGTATTGTGAAATTTTGGGACAAGGATTAACTTGATGCTTAAAGTAACCCCCAACAGTAACTAGGGGGCCACATTCCATC
AGTGAAACTGGAAAGATTGGTGTGGCTGAGAATCAGATGAGCAGAGGCACCTTTAGAAGAAATAATGTGGTAGTATTTATTTAGGGAGAG
ACAGATGTGTTGCCATGTTACTTAGTCATACTAGAGAGCCAGCCAAGTTTGAATAATGAAGGTGCAGACGTGTTGTCTTCTTCACTGACA
AGCTGTCTGAACAAGGAGCCAGGAACTGTCGGGTCACCAGCTGTGGAGCGTGCCGGGGGGACAACCTGCCATTGGATGTAGAGAAAAGTG
CCTTAGAGTTGGCCTGAGCCCTCCTGCCCACTCGCCCTCCGCGCGACGCCACTCGGAGTCCACACGGCACACACAAGCGGAGCTGAGAAG
CACGATGGCTCTAGTCAGAGGACTTTGCTGTCGGTCCAGATTTGAAGAGGACACGGAACAGCATGAGCCTTTGTGACAAAACTAGAATTT
GGAAATGAGGACTGTCTTGGGAAAAGGGTAGACACAGGCACTTCTCTCCACAGCCTGCTAACCTAATGTGGGCAGAACTGAAAGATCACT
GCAGTGGAAACTGTTCTGGAAGAGGCTGCAACATAGCCCATGCTTAGGGACTGGATGGTTTTTGCAAGAGCTTTTTTTTTTTTTAAACTA
CCATCTCCCAACTTTTAAAGCCAGATACTTGACAAGGATTTTAGATCTTAATGGGTTCGATGGTAGGGAATACGGAAAGGATACACTGCT
AATATTGTGTCTAACAATAAAGCAAACAACTCGATGCTGTAAGAAGACAAGCTGTTTGAGCTTTCAAACACACATGCACACAGCACAATT
CAGAAATACCCAGGAGGATTCCTGCAGGCTTAACAGTTGGCATCGTACTGAAATGAAACGTGTATTAACAAGAAAATGTCAAACTTTTGG
GGAAACAAATTTTCTGTTACTTCCCACCCAACTAAAAGGGAAGATAAAACCATCATCACCAGAACAAAACAGATTTTCTCCAAACAAGTA
CAATGATAGTGCCGGGTTGGCAGTTAACTCTTTCACCCTACTAAATTCAAGAGCTCATCTCCACCCTGTCCTGTATATTTTCTACATTTC
TATTAAGAGGCTACTTGGTAGTGTCAGCGGGCATCTTTTACACCTTCTAGTAGCTCAAGCTAGTAAAACCTTGTACTTCTCTATTGCGCC

>1151_1151_1_ACACA-FAM104A_ACACA_chr17_35631084_ENST00000353139_FAM104A_chr17_71205907_ENST00000403627_length(amino acids)=422AA_BP=342
MRRNDERMWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKE
GSLSPASVGSDTLSDLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRS
IRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNG
IAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQSSGSDSGGSSSSSSSSI

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>1151_1151_2_ACACA-FAM104A_ACACA_chr17_35631084_ENST00000360679_FAM104A_chr17_71205907_ENST00000403627_length(transcript)=3574nt_BP=1158nt
GGCAGCCAGGAGAGGCAGTGGAGCTTTTCTCCGTTGACTGTCAGAAGAAAGTGACTGTTGTTGAAAATGTTTGCTGCAACTAAAGGAGAG
CTGCTAAGATCTACTTTCTAGTTAAACAAGCTTTTATATTTCTCCCCGGCTCCTCTCAGTTCCCTTGGGAAATCAACTAATTGTGTGTGT
AAGCTAAGTGTGTGGAGGAGAGAAGATGCAAAAAGGAAGAGAAAGGTGGGGAAAGAAGGAAATTGGGAACAATTAGACAAAAAGACTATA
GTTTGAGGCCATCAGGAGTATTCTAGTCTGACTGAAGCCAGGCAGAAGGCACAGTATCTCTTGTCCTCCTGGGTTTTAAGCAGCTGCAAC
AGGAGGAGGAACTGCGGCTTGTGTTTACAAGGCCGAAATCTGAAGAAAAAGCTTCCATTCTTTTCCCATCTTGATATGGAGGGTTCTCCA
GAGGAAAATAAGGAAATGAGATATTACATGCTTCAAAGGTCCAGCATGTCTGGCTTGCACCTAGTAAAGCAGGGCCGAGACAGAAAGAAA
ATAGATTCTCAACGAGATTTCACTGTGGCTTCTCCAGCAGAATTTGTTACTCGCTTTGGGGGAAATAAAGTGATTGAGAAGGTTCTTATT
GCTAACAATGGCATTGCAGCAGTGAAATGCATGCGGTCTATCCGTAGGTGGTCTTATGAAATGTTTCGAAATGAACGTGCAATTAGATTC
GTTGTCATGGTCACACCTGAAGACCTTAAAGCCAATGCAGAATACATTAAGATGGCAGATCACTATGTGCCAGTGCCTGGAGGACCAAAC
AACAACAACTATGCAAATGTGGAATTAATTCTTGATATTGCTAAAAGGATCCCAGTACAAGCAGTGTGGGCTGGCTGGGGTCATGCTTCT
GAGAATCCCAAACTACCGGAACTTCTCTTGAAAAATGGCATTGCCTTCATGGGTCCTCCAAGCCAGGCCATGTGGGCTTTAGGGGATAAG
ATTGCATCTTCCATAGTGGCTCAAACTGCAGGTATCCCAACTCTTCCCTGGAGCGGCAGTGGTCTTCGTGTGGACTGGCAGGAAAATGAT
TTTTCAAAACGTATCTTAAATGTTCCCCAGGAGCTATATGAAAAAGGTTATGTGAAAGATGTGGATGATGGGCTACAGTCTTCAGGCAGT
GACAGTGGTGGGAGCAGCAGCAGCAGCAGCAGCAGCATCAATAGCCCGGACAGGGCCAGCGGGCCGGAAGGCAGCTTGAGCCAGACCATG
GCCGGATCCAGCCCTAACACGCCTCAGCCCGTGCCCGAGCAGTCCGCGCTGTGCCAAGGCCTCTACTTCCACATCAACCAGACCCTGAGG
GAGGCCCACTTCCACAGCCTACAGCACCGAGGGCGGCCTCTGACATGATGTGCCGGCAGTTTCTTGCCTTCTGTGAAGGGACAGCGCTGT
GCAGATTTGATATTTCAACTTACAACTTGTTTTAAAAGAAAAATTGCACACGAAAAATGCCTGTTGGCTTTTCAGTCTATATTTGAAATA
ACAGGTTAACAGGCAGTTGTTTACTTGTGGTTTTGCTGCACTATTGCAATTTCAAAGGGGCTTTGAAGCAATTTTTTATAGGATTCTTTT
GAGGGAGGGTATCAAATCTATGTCAAGGTAGTGGTTTGAGGAAAACTCATTCTGTGTGTTGAATCCATAGTATGTCCCATTCAGACTGAT
TTCCAAATCTGTCAACTAGAAACTCTACTTTATGTAAAGGGCCTTTTAAAAATGCGGGATCTTCAATTTTTTTTATTCAATAAACTAGTA
AAGAGTATCTAGTTTCCATGAAAAAACATAAGTTTTTTTCCAAAATATAGGAAGCTTGATTCAGTCTTGCACTGAAATTAACTGCCATAC
TACCTCTCAGTATGTAGATGTTCTATTGAAAGTACTCTCTCCTGTGTAACAGGAGAACAATCAGATCCAATTCAGACTGTCAGTGAAGCA
CACTCCCTAATAATAGTCTCTACTCTTTGTTATATATTTGTATTTCCAGAGAGAATGTCTTTTAGATTCTTGTATACCCAGATAACTTCT
GTGTCACTATTCCACCAGAGTCTGCACCTCAGACTTTAGTAGGAAACATGGCACAGTTCTGCAAGTAAAGTAATATGTAATGACTTTTTG
TCCTACAAACTTGGTCAGTCAGCAGCTTACATGATCTCATTGACAATTCCACCTTGTAGTGTCAACAATTAAGGTGTTGTTGAACGCTGA
TAAAATGTAAGCTACCTGAACTGATGTCTAAAGCAACAAGTATTGTGAAATTTTGGGACAAGGATTAACTTGATGCTTAAAGTAACCCCC
AACAGTAACTAGGGGGCCACATTCCATCAGTGAAACTGGAAAGATTGGTGTGGCTGAGAATCAGATGAGCAGAGGCACCTTTAGAAGAAA
TAATGTGGTAGTATTTATTTAGGGAGAGACAGATGTGTTGCCATGTTACTTAGTCATACTAGAGAGCCAGCCAAGTTTGAATAATGAAGG
TGCAGACGTGTTGTCTTCTTCACTGACAAGCTGTCTGAACAAGGAGCCAGGAACTGTCGGGTCACCAGCTGTGGAGCGTGCCGGGGGGAC
AACCTGCCATTGGATGTAGAGAAAAGTGCCTTAGAGTTGGCCTGAGCCCTCCTGCCCACTCGCCCTCCGCGCGACGCCACTCGGAGTCCA
CACGGCACACACAAGCGGAGCTGAGAAGCACGATGGCTCTAGTCAGAGGACTTTGCTGTCGGTCCAGATTTGAAGAGGACACGGAACAGC
ATGAGCCTTTGTGACAAAACTAGAATTTGGAAATGAGGACTGTCTTGGGAAAAGGGTAGACACAGGCACTTCTCTCCACAGCCTGCTAAC
CTAATGTGGGCAGAACTGAAAGATCACTGCAGTGGAAACTGTTCTGGAAGAGGCTGCAACATAGCCCATGCTTAGGGACTGGATGGTTTT
TGCAAGAGCTTTTTTTTTTTTTAAACTACCATCTCCCAACTTTTAAAGCCAGATACTTGACAAGGATTTTAGATCTTAATGGGTTCGATG
GTAGGGAATACGGAAAGGATACACTGCTAATATTGTGTCTAACAATAAAGCAAACAACTCGATGCTGTAAGAAGACAAGCTGTTTGAGCT
TTCAAACACACATGCACACAGCACAATTCAGAAATACCCAGGAGGATTCCTGCAGGCTTAACAGTTGGCATCGTACTGAAATGAAACGTG
TATTAACAAGAAAATGTCAAACTTTTGGGGAAACAAATTTTCTGTTACTTCCCACCCAACTAAAAGGGAAGATAAAACCATCATCACCAG
AACAAAACAGATTTTCTCCAAACAAGTACAATGATAGTGCCGGGTTGGCAGTTAACTCTTTCACCCTACTAAATTCAAGAGCTCATCTCC
ACCCTGTCCTGTATATTTTCTACATTTCTATTAAGAGGCTACTTGGTAGTGTCAGCGGGCATCTTTTACACCTTCTAGTAGCTCAAGCTA

>1151_1151_2_ACACA-FAM104A_ACACA_chr17_35631084_ENST00000360679_FAM104A_chr17_71205907_ENST00000403627_length(amino acids)=366AA_BP=286
MTEARQKAQYLLSSWVLSSCNRRRNCGLCLQGRNLKKKLPFFSHLDMEGSPEENKEMRYYMLQRSSMSGLHLVKQGRDRKKIDSQRDFTV
ASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVEL
ILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVP
QELYEKGYVKDVDDGLQSSGSDSGGSSSSSSSSINSPDRASGPEGSLSQTMAGSSPNTPQPVPEQSALCQGLYFHINQTLREAHFHSLQH

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Fusion Gene PPI Analysis for ACACA-FAM104A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACACA-FAM104A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACACA-FAM104A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACACAC0018801Heart failure1CTD_human
HgeneACACAC0018802Congestive heart failure1CTD_human
HgeneACACAC0023212Left-Sided Heart Failure1CTD_human
HgeneACACAC0235527Heart Failure, Right-Sided1CTD_human
HgeneACACAC1959583Myocardial Failure1CTD_human
HgeneACACAC1961112Heart Decompensation1CTD_human
HgeneACACAC2239176Liver carcinoma1CTD_human