Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ACACA-ADAM9 (FusionGDB2 ID:HG31TG8754)

Fusion Gene Summary for ACACA-ADAM9

check button Fusion gene summary
Fusion gene informationFusion gene name: ACACA-ADAM9
Fusion gene ID: hg31tg8754
HgeneTgene
Gene symbol

ACACA

ADAM9

Gene ID

31

8754

Gene nameacetyl-CoA carboxylase alphaADAM metallopeptidase domain 9
SynonymsACAC|ACACAD|ACC|ACC1|ACCACORD9|MCMP|MDC9|Mltng
Cytomap('ACACA')('ADAM9')

17q12

8p11.22

Type of geneprotein-codingprotein-coding
Descriptionacetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alphadisintegrin and metalloproteinase domain-containing protein 9ADAM metallopeptidase domain 9 (meltrin gamma)cellular disintegrin-related proteincone rod dystrophy 9metalloprotease/disintegrin/cysteine-rich protein 9myeloma cell metalloproteinase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000353139, ENST00000394406, 
ENST00000416895, ENST00000588142, 
ENST00000335166, ENST00000360679, 
ENST00000361253, ENST00000589665, 
Fusion gene scores* DoF score44 X 35 X 17=2618012 X 12 X 8=1152
# samples 5113
** MAII scorelog2(51/26180*10)=-5.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/1152*10)=-3.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACACA [Title/Abstract] AND ADAM9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACACA(35687113)-ADAM9(38865405), # samples:3
Anticipated loss of major functional domain due to fusion event.ACACA-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACACA-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACACA-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACACA-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACACA-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ACACA-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ACACA-ADAM9 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADAM9

GO:0000186

activation of MAPKK activity

17704059

TgeneADAM9

GO:0006509

membrane protein ectodomain proteolysis

9920899

TgeneADAM9

GO:0034612

response to tumor necrosis factor

11831872

TgeneADAM9

GO:0050714

positive regulation of protein secretion

17704059


check buttonFusion gene breakpoints across ACACA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ADAM9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FJ-A3ZE-01AACACAchr17

35687113

-ADAM9chr8

38865405

+


Top

Fusion Gene ORF analysis for ACACA-ADAM9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000353139ENST00000484143ACACAchr17

35687113

-ADAM9chr8

38865405

+
5CDS-intronENST00000394406ENST00000484143ACACAchr17

35687113

-ADAM9chr8

38865405

+
5CDS-intronENST00000416895ENST00000484143ACACAchr17

35687113

-ADAM9chr8

38865405

+
5CDS-intronENST00000588142ENST00000484143ACACAchr17

35687113

-ADAM9chr8

38865405

+
Frame-shiftENST00000353139ENST00000466936ACACAchr17

35687113

-ADAM9chr8

38865405

+
Frame-shiftENST00000353139ENST00000481513ACACAchr17

35687113

-ADAM9chr8

38865405

+
Frame-shiftENST00000353139ENST00000487273ACACAchr17

35687113

-ADAM9chr8

38865405

+
Frame-shiftENST00000394406ENST00000466936ACACAchr17

35687113

-ADAM9chr8

38865405

+
Frame-shiftENST00000394406ENST00000481513ACACAchr17

35687113

-ADAM9chr8

38865405

+
Frame-shiftENST00000394406ENST00000487273ACACAchr17

35687113

-ADAM9chr8

38865405

+
Frame-shiftENST00000588142ENST00000466936ACACAchr17

35687113

-ADAM9chr8

38865405

+
Frame-shiftENST00000588142ENST00000481513ACACAchr17

35687113

-ADAM9chr8

38865405

+
Frame-shiftENST00000588142ENST00000487273ACACAchr17

35687113

-ADAM9chr8

38865405

+
In-frameENST00000416895ENST00000466936ACACAchr17

35687113

-ADAM9chr8

38865405

+
In-frameENST00000416895ENST00000481513ACACAchr17

35687113

-ADAM9chr8

38865405

+
In-frameENST00000416895ENST00000487273ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-3CDSENST00000335166ENST00000466936ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-3CDSENST00000335166ENST00000481513ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-3CDSENST00000335166ENST00000487273ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-3CDSENST00000360679ENST00000466936ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-3CDSENST00000360679ENST00000481513ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-3CDSENST00000360679ENST00000487273ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-3CDSENST00000361253ENST00000466936ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-3CDSENST00000361253ENST00000481513ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-3CDSENST00000361253ENST00000487273ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-3CDSENST00000589665ENST00000466936ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-3CDSENST00000589665ENST00000481513ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-3CDSENST00000589665ENST00000487273ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-intronENST00000335166ENST00000484143ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-intronENST00000360679ENST00000484143ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-intronENST00000361253ENST00000484143ACACAchr17

35687113

-ADAM9chr8

38865405

+
intron-intronENST00000589665ENST00000484143ACACAchr17

35687113

-ADAM9chr8

38865405

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000416895ACACAchr1735687113-ENST00000487273ADAM9chr838865405+44848209633182739
ENST00000416895ACACAchr1735687113-ENST00000466936ADAM9chr838865405+2581820461853130
ENST00000416895ACACAchr1735687113-ENST00000481513ADAM9chr838865405+3032820461853130

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000416895ENST00000487273ACACAchr1735687113-ADAM9chr838865405+0.0002159550.99978405
ENST00000416895ENST00000466936ACACAchr1735687113-ADAM9chr838865405+0.328002240.6719978
ENST00000416895ENST00000481513ACACAchr1735687113-ADAM9chr838865405+0.206858070.7931419

Top

Fusion Genomic Features for ACACA-ADAM9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACACAchr1735687112-ADAM9chr838865404+6.62E-091
ACACAchr1735687112-ADAM9chr838865404+6.62E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ACACA-ADAM9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:35687113/chr8:38865405)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADAM9chr17:35687113chr8:38865405ENST00000487273022505_63432820.0Compositional biasNote=Cys-rich
TgeneADAM9chr17:35687113chr8:38865405ENST00000487273022790_79532820.0Compositional biasNote=Poly-Pro
TgeneADAM9chr17:35687113chr8:38865405ENST00000487273022212_40632820.0DomainPeptidase M12B
TgeneADAM9chr17:35687113chr8:38865405ENST00000487273022414_50132820.0DomainDisintegrin
TgeneADAM9chr17:35687113chr8:38865405ENST00000487273022644_69832820.0DomainEGF-like
TgeneADAM9chr17:35687113chr8:38865405ENST00000487273022719_81932820.0Topological domainCytoplasmic
TgeneADAM9chr17:35687113chr8:38865405ENST00000487273022698_71832820.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACACAchr17:35687113chr8:38865405ENST00000335166-155117_61802269.0DomainBiotin carboxylation
HgeneACACAchr17:35687113chr8:38865405ENST00000335166-1551576_191402269.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35687113chr8:38865405ENST00000335166-1551918_223402269.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35687113chr8:38865405ENST00000335166-155275_46602269.0DomainATP-grasp
HgeneACACAchr17:35687113chr8:38865405ENST00000335166-155745_81902269.0DomainBiotinyl-binding
HgeneACACAchr17:35687113chr8:38865405ENST00000353139-356117_6181122384.0DomainBiotin carboxylation
HgeneACACAchr17:35687113chr8:38865405ENST00000353139-3561576_19141122384.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35687113chr8:38865405ENST00000353139-3561918_22341122384.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35687113chr8:38865405ENST00000353139-356275_4661122384.0DomainATP-grasp
HgeneACACAchr17:35687113chr8:38865405ENST00000353139-356745_8191122384.0DomainBiotinyl-binding
HgeneACACAchr17:35687113chr8:38865405ENST00000360679-154117_61802289.0DomainBiotin carboxylation
HgeneACACAchr17:35687113chr8:38865405ENST00000360679-1541576_191402289.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35687113chr8:38865405ENST00000360679-1541918_223402289.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35687113chr8:38865405ENST00000360679-154275_46602289.0DomainATP-grasp
HgeneACACAchr17:35687113chr8:38865405ENST00000360679-154745_81902289.0DomainBiotinyl-binding
HgeneACACAchr17:35687113chr8:38865405ENST00000394406-356117_618752347.0DomainBiotin carboxylation
HgeneACACAchr17:35687113chr8:38865405ENST00000394406-3561576_1914752347.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35687113chr8:38865405ENST00000394406-3561918_2234752347.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35687113chr8:38865405ENST00000394406-356275_466752347.0DomainATP-grasp
HgeneACACAchr17:35687113chr8:38865405ENST00000394406-356745_819752347.0DomainBiotinyl-binding
HgeneACACAchr17:35687113chr8:38865405ENST00000335166-155315_32002269.0Nucleotide bindingATP
HgeneACACAchr17:35687113chr8:38865405ENST00000353139-356315_3201122384.0Nucleotide bindingATP
HgeneACACAchr17:35687113chr8:38865405ENST00000360679-154315_32002289.0Nucleotide bindingATP
HgeneACACAchr17:35687113chr8:38865405ENST00000394406-356315_320752347.0Nucleotide bindingATP
HgeneACACAchr17:35687113chr8:38865405ENST00000335166-1551576_223402269.0RegionCarboxyltransferase
HgeneACACAchr17:35687113chr8:38865405ENST00000353139-3561576_22341122384.0RegionCarboxyltransferase
HgeneACACAchr17:35687113chr8:38865405ENST00000360679-1541576_223402289.0RegionCarboxyltransferase
HgeneACACAchr17:35687113chr8:38865405ENST00000394406-3561576_2234752347.0RegionCarboxyltransferase
TgeneADAM9chr17:35687113chr8:38865405ENST0000048727302229_69732820.0Topological domainExtracellular


Top

Fusion Gene Sequence for ACACA-ADAM9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1135_1135_1_ACACA-ADAM9_ACACA_chr17_35687113_ENST00000416895_ADAM9_chr8_38865405_ENST00000466936_length(transcript)=2581nt_BP=820nt
GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG
ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC
CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG
GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT
TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC
AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGGTCTTTCTGGAAGTGGATAT
CTACTCAGACAGTAAGAATTATAAGAGCTGTAAGAGCTCATTTTGGAGGAATAATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGC
TGAACCAGCACTCTCGATTCATAATAGGTTCTGTGTCTGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGTTGGACCTACTGG
AGGAGAAGGAGGGCTCCTTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCTGATTTGGGGATCTCTAGCCTACAGGATGGCTTGGCCT
TGCACATAAGGCTTTCAACAGACCTCACATCTTTCTTCTTATGAAATTATAACTCCTTGGAGATTAACTAGAGAAAGAAGAGAAGCCCCT
AGGCCCTATTCAAAACAAGTATCTTATGTTATTCAGGCTGAAGGAAAAGAGCATATTATTCACTTGGAAAGGAACAAAGACCTTTTGCCT
GAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGACTTTAATCACTGACCATCCCAATATACAGAGGTGTGGTCCTCTCTGCATCAGA
GAACAGAGTACTCCTGGGGACAGAGCTGGCCAGAATACCCAAAATAATTGGCAGATGTCAAATTTGGCTTTCTGTGTTTATTACTAGAGC
ATAAACATTTCTAGTTTTGTTTGAGTGTTTTACAGTCCTTTTTGGCAGTTAGGTATTATACCTTTTTTTCTTTTGCAATGGTTTTCATGA
GAAATCTTTATTCCCATTACATGTGTATGTTTTATTTTTCTTCTGAACTTTGTAATACTTTGCTATGTTGAATTGTTTCTGTTGGTAGCG
CACTTTTGCAGCATTCTTCAAATAGGAGGCAAAAAAATCTTTAGATTAATTATTAGTACTTACAAAAACCAAGGAAATGCTGACTTAGGC
CTATCTTCTGGTCCACTATCTGATTTCTTTATCTTAGTGTGTTGTTGGTCCATTGTTTAATAGAAAATTAGTAGAGGAGTTTGAATTTAC
CTTACAGCATAAACCAGATAGAAAATAACGCATTCATCCAGTCATGCATCCAATGATTACCAAGGCAGAAGGCCAAACACCACATAATTT
GTGTCACTTGACAAAAGCAGTAATGTTAAAAGGCATTTTTTTCCTCATAGAGGTTTCTTGGCATACTTTCTTCAGACATACACTGTTTGG
GCTTGAGTTTTGACTCATTATTTGCTGATGAAGCTACTTTAATCTGTTTGTGCCTTGGTATCTTCGCTTTAAAATGTAATAATAGTTACC
ACTTTATGGATATACTGGGAAACTTAACTGAGTTAATACTTACAAGATGCTTAGAACAGTCTGACAATTTTTAACTCAACGAATGTTATT
ATTTGTTGCTATTATTGACAGCGTATGTTCTTAAAACTGCCAAAAATTGATTTAATTATATAGAAACTTATGTAACTATTATCTTATATA
ATACTTAAGTATCATAAGTATGATAGAGTTATGCTTTTCTGGGTGTTTGAAAAATGTCAACTAAGACAGATGGTGTCTCACTTATTTCTT
GGTTATTTAATATTGTTCAGTTAGATGAAAGTGTGATTGTAGATTTGAAATACAAAATAAAACTTGGATACTGTGATTTTTTTAACATGG
CCAGACTGTCATGTATTATAATGACATATACTTTTGTCCATAAAATGAAATTAAGTTTCACTGAAAAATTTACATACTTTCCCCTGGGGA
TTCTATTGCTTCAGATTAAAGTTTATAAAGTATCATTAGTGTCTTCCACAGGGTCATTTTACACAAACACAGTTTTAGTGAGATGTCAAC
TGGCTTTTGTTGGTTGTTGGATTGACTGTGATTTAAAATGTTAAAGATGATATAATGCATCTTGTTCTGCTTCTAGGCTGAAAGGTCACT
GAGGCAGAGCTGTTTGTACCTTGTATCCCCTGGAATTTTGCCTAAACATTTGTGTACTCATAGGGTGGTAGGAGATAGTCCGCAGATGGT

>1135_1135_1_ACACA-ADAM9_ACACA_chr17_35687113_ENST00000416895_ADAM9_chr8_38865405_ENST00000466936_length(amino acids)=130AA_BP=
MRRNDERMWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKE

--------------------------------------------------------------
>1135_1135_2_ACACA-ADAM9_ACACA_chr17_35687113_ENST00000416895_ADAM9_chr8_38865405_ENST00000481513_length(transcript)=3032nt_BP=820nt
GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG
ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC
CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG
GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT
TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC
AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGGTCTTTCTGGAAGTGGATAT
CTACTCAGACAGTAAGAATTATAAGAGCTGTAAGAGCTCATTTTGGAGGAATAATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGC
TGAACCAGCACTCTCGATTCATAATAGGTTCTGTGTCTGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGTTGGACCTACTGG
AGGAGAAGGAGGGCTCCTTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCTGATTTGGGGATCTCTAGCCTACAGGATGGCTTGGCCT
TGCACATAAGGCTTTCAACAGACCTCACATCTTTCTTCTTATGAAATTATAACTCCTTGGAGATTAACTAGAGAAAGAAGAGAAGCCCCT
AGGCCCTATTCAAAACAAGTATCTTATGTTATTCAGGCTGAAGGAAAAGAGCATATTATTCACTTGGAAAGGAACAAAGACCTTTTGCCT
GAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGACTTTAATCACTGACCATCCCAATATACAGGTAATGTATTTTTCTCTTGATCCC
ATAGCAAATTTTAAAACAATTATAATTTAAAAATGAGTTCTGTATAGGCACTCAGGACTGTTACATTGCACAGCCCCACAGGGTACCTTT
AACATTATAACATATGGGTTATCTTGGGAAAAGTGGGTGCATTTCTATAGACTAAGCTGTACCTTACAGCTCTCCAGGTACTCAGTAGTT
AAGGTTTTTTTTTTAAAGACTAGGAAAATAAATCTTCTATTTAATGGTAATCCTTACTGATGAGAAAATTTGATATGTTTTGAAAATAGG
AGTTTCTGATTTTTTTGTTGAAAGTTAATATCTCTAAAAGTGCACTTATTAAAACATTTAATTTGTCAGTGATATTTAGTAAAGAAAAAC
ACTCATTTGATGTTATGTGTTCTAATGTTCTAAATTTTTTCTGAAAATAATTGTTTCCTAAAAGAGGTGTGGTCCTCTCTGCATCAGAGA
ACAGAGTACTCCTGGGGACAGAGCTGGCCAGAATACCCAAAATAATTGGCAGATGTCAAATTTGGCTTTCTGTGTTTATTACTAGAGCAT
AAACATTTCTAGTTTTGTTTGAGTGTTTTACAGTCCTTTTTGGCAGTTAGGTATTATACCTTTTTTTCTTTTGCAATGGTTTTCATGAGA
AATCTTTATTCCCATTACATGTGTATGTTTTATTTTTCTTCTGAACTTTGTAATACTTTGCTATGTTGAATTGTTTCTGTTGGTAGCGCA
CTTTTGCAGCATTCTTCAAATAGGAGGCAAAAAAATCTTTAGATTAATTATTAGTACTTACAAAAACCAAGGAAATGCTGACTTAGGCCT
ATCTTCTGGTCCACTATCTGATTTCTTTATCTTAGTGTGTTGTTGGTCCATTGTTTAATAGAAAATTAGTAGAGGAGTTTGAATTTACCT
TACAGCATAAACCAGATAGAAAATAACGCATTCATCCAGTCATGCATCCAATGATTACCAAGGCAGAAGGCCAAACACCACATAATTTGT
GTCACTTGACAAAAGCAGTAATGTTAAAAGGCATTTTTTTCCTCATAGAGGTTTCTTGGCATACTTTCTTCAGACATACACTGTTTGGGC
TTGAGTTTTGACTCATTATTTGCTGATGAAGCTACTTTAATCTGTTTGTGCCTTGGTATCTTCGCTTTAAAATGTAATAATAGTTACCAC
TTTATGGATATACTGGGAAACTTAACTGAGTTAATACTTACAAGATGCTTAGAACAGTCTGACAATTTTTAACTCAACGAATGTTATTAT
TTGTTGCTATTATTGACAGCGTATGTTCTTAAAACTGCCAAAAATTGATTTAATTATATAGAAACTTATGTAACTATTATCTTATATAAT
ACTTAAGTATCATAAGTATGATAGAGTTATGCTTTTCTGGGTGTTTGAAAAATGTCAACTAAGACAGATGGTGTCTCACTTATTTCTTGG
TTATTTAATATTGTTCAGTTAGATGAAAGTGTGATTGTAGATTTGAAATACAAAATAAAACTTGGATACTGTGATTTTTTTAACATGGCC
AGACTGTCATGTATTATAATGACATATACTTTTGTCCATAAAATGAAATTAAGTTTCACTGAAAAATTTACATACTTTCCCCTGGGGATT
CTATTGCTTCAGATTAAAGTTTATAAAGTATCATTAGTGTCTTCCACAGGGTCATTTTACACAAACACAGTTTTAGTGAGATGTCAACTG
GCTTTTGTTGGTTGTTGGATTGACTGTGATTTAAAATGTTAAAGATGATATAATGCATCTTGTTCTGCTTCTAGGCTGAAAGGTCACTGA
GGCAGAGCTGTTTGTACCTTGTATCCCCTGGAATTTTGCCTAAACATTTGTGTACTCATAGGGTGGTAGGAGATAGTCCGCAGATGGTCT

>1135_1135_2_ACACA-ADAM9_ACACA_chr17_35687113_ENST00000416895_ADAM9_chr8_38865405_ENST00000481513_length(amino acids)=130AA_BP=
MRRNDERMWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKE

--------------------------------------------------------------
>1135_1135_3_ACACA-ADAM9_ACACA_chr17_35687113_ENST00000416895_ADAM9_chr8_38865405_ENST00000487273_length(transcript)=4484nt_BP=820nt
GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG
ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC
CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG
GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT
TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC
AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGGTCTTTCTGGAAGTGGATAT
CTACTCAGACAGTAAGAATTATAAGAGCTGTAAGAGCTCATTTTGGAGGAATAATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGC
TGAACCAGCACTCTCGATTCATAATAGGTTCTGTGTCTGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGTTGGACCTACTGG
AGGAGAAGGAGGGCTCCTTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCTGATTTGGGGATCTCTAGCCTACAGGATGGCTTGGCCT
TGCACATAAGGCTTTCAACAGACCTCACATCTTTCTTCTTATGAAATTATAACTCCTTGGAGATTAACTAGAGAAAGAAGAGAAGCCCCT
AGGCCCTATTCAAAACAAGTATCTTATGTTATTCAGGCTGAAGGAAAAGAGCATATTATTCACTTGGAAAGGAACAAAGACCTTTTGCCT
GAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGACTTTAATCACTGACCATCCCAATATACAGAATCATTGTCATTATCGGGGCTAT
GTGGAGGGAGTTCATAATTCATCCATTGCTCTTAGCGACTGTTTTGGACTCAGAGGATTGCTGCATTTAGAGAATGCGAGTTATGGGATT
GAACCCCTGCAGAACAGCTCTCATTTTGAGCACATCATTTATCGAATGGATGATGTCTACAAAGAGCCTCTGAAATGTGGAGTTTCCAAC
AAGGATATAGAGAAAGAAACTGCAAAGGATGAAGAGGAAGAGCCTCCCAGCATGACTCAGCTACTTCGAAGAAGAAGAGCTGTCTTGCCA
CAGACCCGGTATGTGGAGCTGTTCATTGTCGTAGACAAGGAAAGGTATGACATGATGGGAAGAAATCAGACTGCTGTGAGAGAAGAGATG
ATTCTCCTGGCAAACTACTTGGATAGTATGTATATTATGTTAAATATTCGAATTGTGCTAGTTGGACTGGAGATTTGGACCAATGGAAAC
CTGATCAACATAGTTGGGGGTGCTGGTGATGTGCTGGGGAACTTCGTGCAGTGGCGGGAAAAGTTTCTTATCACACGTCGGAGACATGAC
AGTGCACAGCTAGTTCTAAAGAAAGGTTTTGGTGGAACTGCAGGAATGGCATTTGTGGGAACAGTGTGTTCAAGGAGCCACGCAGGCGGG
ATTAATGTGTTTGGACAAATCACTGTGGAGACATTTGCTTCCATTGTTGCTCATGAATTGGGTCATAATCTTGGAATGAATCACGATGAT
GGGAGAGATTGTTCCTGTGGAGCAAAGAGCTGCATCATGAATTCAGGAGCATCGGGTTCCAGAAACTTTAGCAGTTGCAGTGCAGAGGAC
TTTGAGAAGTTAACTTTAAATAAAGGAGGAAACTGCCTTCTTAATATTCCAAAGCCTGATGAAGCCTATAGTGCTCCCTCCTGTGGTAAT
AAGTTGGTGGACGCTGGGGAAGAGTGTGACTGTGGTACTCCAAAGGAATGTGAATTGGACCCTTGCTGCGAAGGAAGTACCTGTAAGCTT
AAATCATTTGCTGAGTGTGCATATGGTGACTGTTGTAAAGACTGTCGGTTCCTTCCAGGAGGTACTTTATGCCGAGGAAAAACCAGTGAG
TGTGATGTTCCAGAGTACTGCAATGGTTCTTCTCAGTTCTGTCAGCCAGATGTTTTTATTCAGAATGGATATCCTTGCCAGAATAACAAA
GCCTATTGCTACAACGGCATGTGCCAGTATTATGATGCTCAATGTCAAGTCATCTTTGGCTCAAAAGCCAAGGCTGCCCCCAAAGATTGT
TTCATTGAAGTGAATTCTAAAGGTGACAGATTTGGCAATTGTGGTTTCTCTGGCAATGAATACAAGAAGTGTGCCACTGGGAATGCTTTG
TGTGGAAAGCTTCAGTGTGAGAATGTACAAGAGATACCTGTATTTGGAATTGTGCCTGCTATTATTCAAACGCCTAGTCGAGGCACCAAA
TGTTGGGGTGTGGATTTCCAGCTAGGATCAGATGTTCCAGATCCTGGGATGGTTAACGAAGGCACAAAATGTGGTGCTGGAAAGATCTGT
AGAAACTTCCAGTGTGTAGATGCTTCTGTTCTGAATTATGACTGTGATGTTCAGAAAAAGTGTCATGGACATGGGGTATGTAATAGCAAT
AAGAATTGTCACTGTGAAAATGGCTGGGCTCCCCCAAATTGTGAGACTAAAGGATACGGAGGAAGTGTGGACAGTGGACCTACATACAAT
GAAATGAATACTGCATTGAGGGACGGACTTCTGGTCTTCTTCTTCCTAATTGTTCCCCTTATTGTCTGTGCTATTTTTATCTTCATCAAG
AGGGATCAACTGTGGAGAAGCTACTTCAGAAAGAAGAGATCACAAACATATGAGTCAGATGGCAAAAATCAAGCAAACCCTTCTAGACAG
CCGGGGAGTGTTCCTCGACATGTTTCTCCAGTGACACCTCCCAGAGAAGTTCCTATATATGCAAACAGATTTGCAGTACCAACCTATGCA
GCCAAGCAACCTCAGCAGTTCCCATCAAGGCCACCTCCACCACAACCGAAAGTATCATCTCAGGGAAACTTAATTCCTGCCCGTCCTGCT
CCTGCACCTCCTTTATATAGTTCCCTCACTTGATTTTTTTAACCTTCTTTTTGCAAATGTCTTCAGGGAACTGAGCTAATACTTTTTTTT
TTTCTTGATGTTTTCTTGAAAAGCCTTTCTGTTGCAACTATGAATGAAAACAAAACACCACAAAACAGACTTCACTAACACAGAAAAACA
GAAACTGAGTGTGAGAGTTGTGAAATACAAGGAAATGCAGTAAAGCCAGGGAATTTACAATAACATTTCCGTTTCCATCATTGAATAAGT
CTTATTCAGTCATCGGTGAGGTTAATGCACTAATCATGGATTTTTTGAACATGTTATTGCAGTGATTCTCAAATTAACTGTATTGGTGTA
AGAGTTTTGTCATTAAGTGTTTAAGTGTTATTCTGAATTTTCTACCTTAGTTATCATTAATGTAGTTCCTCATTGAACATGTGATAATCT
AATACCTGTGAAAACTGACTAATCAGCTGCCAATAATATCTAATATTTTTCATCATGCACGAATTAATAATCATCATACTCTAGAATCTT
GTCTGTCACTCACTACATGAATAAGCAAATATTGTCTTCAAAAGAATGCACAAGAACCACAATTAAGATGTCATATTATTTTGAAAGTAC
AAAATATACTAAAAGAGTGTGTGTGTATTCACGCAGTTACTCGCTTCCATTTTTATGACCTTTCAACTATAGGTAATAACTCTTAGAGAA
ATTAATTTAATATTAGAATTTCTATTATGAATCATGTGAAAGCATGACATTCGTTCACAATAGCACTATTTTAAATAAATTATAAGCTTT
AAGGTACGAAGTATTTAATAGATCTAATCAAATATGTTGATTCATGGCTATAATAAAGCAGGAGCAATTATAAAATCTTCAATCAATTGA
ACTTTTACAAAACCACTTGAGAATTTCATGAGCACTTTAAAATCTGAACTTTCAAAGCTTGCTATTAAATCATTTAGAATGTTTACATTT
ACTAAGGTGTGCTGGGTCATGTAAAATATTAGACACTAATATTTTCATAGAAATTAGGCTGGAGAAAGAAGGAAGAAATGGTTTTCTTAA
ATACCTACAAAAAAGTTACTGTGGTATCTATGAGTTATCATCTTAGCTGTGTTAAAAATGAATTTTTACTATGGCAGATATGGTATGGAT
CGTAAAATTTTAAGCACTAAAAATTTTTTCATAACCTTTCATAATAAAGTTTAATAATAGGTTTATTAACTGAATTTCATTAGTTTTTTA

>1135_1135_3_ACACA-ADAM9_ACACA_chr17_35687113_ENST00000416895_ADAM9_chr8_38865405_ENST00000487273_length(amino acids)=739AA_BP=
MERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYK
EPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLV
GLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELG
HNLGMNHDDGRDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDP
CCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGS
KAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEG
TKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLI
VCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ACACA-ADAM9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ACACA-ADAM9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ACACA-ADAM9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACACAC0018801Heart failure1CTD_human
HgeneACACAC0018802Congestive heart failure1CTD_human
HgeneACACAC0023212Left-Sided Heart Failure1CTD_human
HgeneACACAC0235527Heart Failure, Right-Sided1CTD_human
HgeneACACAC1959583Myocardial Failure1CTD_human
HgeneACACAC1961112Heart Decompensation1CTD_human
HgeneACACAC2239176Liver carcinoma1CTD_human
TgeneC0015397Disorder of eye1GENOMICS_ENGLAND
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC1423873CONE-ROD DYSTROPHY 91CTD_human;GENOMICS_ENGLAND
TgeneC3489532Cone-Rod Dystrophy 21ORPHANET