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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ACACA-ADAM9 (FusionGDB2 ID:HG31TG8754)

Fusion Gene Summary for ACACA-ADAM9

Fusion gene summary

Fusion gene information	Fusion gene name: ACACA-ADAM9
	Fusion gene ID: hg31tg8754
		Hgene	Tgene
	Gene symbol	ACACA	ADAM9
	Gene ID	31	8754
	Gene name	acetyl-CoA carboxylase alpha	ADAM metallopeptidase domain 9
	Synonyms	ACAC\|ACACAD\|ACC\|ACC1\|ACCA	CORD9\|MCMP\|MDC9\|Mltng
	Cytomap	('ACACA')('ADAM9') 17q12	8p11.22
	Type of gene	protein-coding	protein-coding
	Description	acetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alpha	disintegrin and metalloproteinase domain-containing protein 9ADAM metallopeptidase domain 9 (meltrin gamma)cellular disintegrin-related proteincone rod dystrophy 9metalloprotease/disintegrin/cysteine-rich protein 9myeloma cell metalloproteinase
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000353139, ENST00000394406, ENST00000416895, ENST00000588142, ENST00000335166, ENST00000360679, ENST00000361253, ENST00000589665,
Fusion gene scores	* DoF score	44 X 35 X 17=26180	12 X 12 X 8=1152
	# samples	51	13
	** MAII score	log2(51/26180*10)=-5.68182403997375 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/1152*10)=-3.14755718841386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ACACA [Title/Abstract] AND ADAM9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ACACA(35687113)-ADAM9(38865405), # samples:3
Anticipated loss of major functional domain due to fusion event.	ACACA-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACACA-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACACA-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACACA-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACACA-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ACACA-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ACACA-ADAM9 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ADAM9	GO:0000186	activation of MAPKK activity	17704059
Tgene	ADAM9	GO:0006509	membrane protein ectodomain proteolysis	9920899
Tgene	ADAM9	GO:0034612	response to tumor necrosis factor	11831872
Tgene	ADAM9	GO:0050714	positive regulation of protein secretion	17704059

Fusion gene breakpoints across ACACA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ADAM9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-FJ-A3ZE-01A	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+

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Fusion Gene ORF analysis for ACACA-ADAM9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000353139	ENST00000484143	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
5CDS-intron	ENST00000394406	ENST00000484143	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
5CDS-intron	ENST00000416895	ENST00000484143	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
5CDS-intron	ENST00000588142	ENST00000484143	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
Frame-shift	ENST00000353139	ENST00000466936	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
Frame-shift	ENST00000353139	ENST00000481513	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
Frame-shift	ENST00000353139	ENST00000487273	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
Frame-shift	ENST00000394406	ENST00000466936	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
Frame-shift	ENST00000394406	ENST00000481513	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
Frame-shift	ENST00000394406	ENST00000487273	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
Frame-shift	ENST00000588142	ENST00000466936	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
Frame-shift	ENST00000588142	ENST00000481513	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
Frame-shift	ENST00000588142	ENST00000487273	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
In-frame	ENST00000416895	ENST00000466936	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
In-frame	ENST00000416895	ENST00000481513	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
In-frame	ENST00000416895	ENST00000487273	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-3CDS	ENST00000335166	ENST00000466936	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-3CDS	ENST00000335166	ENST00000481513	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-3CDS	ENST00000335166	ENST00000487273	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-3CDS	ENST00000360679	ENST00000466936	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-3CDS	ENST00000360679	ENST00000481513	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-3CDS	ENST00000360679	ENST00000487273	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-3CDS	ENST00000361253	ENST00000466936	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-3CDS	ENST00000361253	ENST00000481513	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-3CDS	ENST00000361253	ENST00000487273	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-3CDS	ENST00000589665	ENST00000466936	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-3CDS	ENST00000589665	ENST00000481513	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-3CDS	ENST00000589665	ENST00000487273	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-intron	ENST00000335166	ENST00000484143	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-intron	ENST00000360679	ENST00000484143	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-intron	ENST00000361253	ENST00000484143	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+
intron-intron	ENST00000589665	ENST00000484143	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000416895	ACACA	chr17	35687113	-	ENST00000487273	ADAM9	chr8	38865405	+	4484	820	963	3182	739
ENST00000416895	ACACA	chr17	35687113	-	ENST00000466936	ADAM9	chr8	38865405	+	2581	820	461	853	130
ENST00000416895	ACACA	chr17	35687113	-	ENST00000481513	ADAM9	chr8	38865405	+	3032	820	461	853	130

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000416895	ENST00000487273	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+	0.000215955	0.99978405
ENST00000416895	ENST00000466936	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+	0.32800224	0.6719978
ENST00000416895	ENST00000481513	ACACA	chr17	35687113	-	ADAM9	chr8	38865405	+	0.20685807	0.7931419

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Fusion Genomic Features for ACACA-ADAM9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ACACA	chr17	35687112	-	ADAM9	chr8	38865404	+	6.62E-09	1
ACACA	chr17	35687112	-	ADAM9	chr8	38865404	+	6.62E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACACA-ADAM9

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:35687113/chr8:38865405)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ADAM9

chr17:35687113

chr8:38865405

ENST00000487273

505_634

820.0

Compositional bias

Note=Cys-rich

Tgene

ADAM9

chr17:35687113

chr8:38865405

ENST00000487273

790_795

820.0

Compositional bias

Note=Poly-Pro

Tgene

ADAM9

chr17:35687113

chr8:38865405

ENST00000487273

212_406

820.0

Domain

Peptidase M12B

Tgene

ADAM9

chr17:35687113

chr8:38865405

ENST00000487273

414_501

820.0

Domain

Disintegrin

Tgene

ADAM9

chr17:35687113

chr8:38865405

ENST00000487273

644_698

820.0

Domain

EGF-like

Tgene

ADAM9

chr17:35687113

chr8:38865405

ENST00000487273

719_819

820.0

Topological domain

Cytoplasmic

Tgene

ADAM9

chr17:35687113

chr8:38865405

ENST00000487273

698_718

820.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000335166

117_618

2269.0

Domain

Biotin carboxylation

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000335166

1576_1914

2269.0

Domain

CoA carboxyltransferase N-terminal

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000335166

1918_2234

2269.0

Domain

CoA carboxyltransferase C-terminal

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000335166

275_466

2269.0

Domain

ATP-grasp

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000335166

745_819

2269.0

Domain

Biotinyl-binding

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000353139

117_618

112

2384.0

Domain

Biotin carboxylation

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000353139

1576_1914

112

2384.0

Domain

CoA carboxyltransferase N-terminal

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000353139

1918_2234

112

2384.0

Domain

CoA carboxyltransferase C-terminal

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000353139

275_466

112

2384.0

Domain

ATP-grasp

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000353139

745_819

112

2384.0

Domain

Biotinyl-binding

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000360679

117_618

2289.0

Domain

Biotin carboxylation

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000360679

1576_1914

2289.0

Domain

CoA carboxyltransferase N-terminal

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000360679

1918_2234

2289.0

Domain

CoA carboxyltransferase C-terminal

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000360679

275_466

2289.0

Domain

ATP-grasp

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000360679

745_819

2289.0

Domain

Biotinyl-binding

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000394406

117_618

2347.0

Domain

Biotin carboxylation

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000394406

1576_1914

2347.0

Domain

CoA carboxyltransferase N-terminal

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000394406

1918_2234

2347.0

Domain

CoA carboxyltransferase C-terminal

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000394406

275_466

2347.0

Domain

ATP-grasp

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000394406

745_819

2347.0

Domain

Biotinyl-binding

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000335166

315_320

2269.0

Nucleotide binding

ATP

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000353139

315_320

112

2384.0

Nucleotide binding

ATP

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000360679

315_320

2289.0

Nucleotide binding

ATP

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000394406

315_320

2347.0

Nucleotide binding

ATP

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000335166

1576_2234

2269.0

Region

Carboxyltransferase

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000353139

1576_2234

112

2384.0

Region

Carboxyltransferase

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000360679

1576_2234

2289.0

Region

Carboxyltransferase

Hgene

ACACA

chr17:35687113

chr8:38865405

ENST00000394406

1576_2234

2347.0

Region

Carboxyltransferase

Tgene

ADAM9

chr17:35687113

chr8:38865405

ENST00000487273

29_697

820.0

Topological domain

Extracellular

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Fusion Gene Sequence for ACACA-ADAM9

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>1135_1135_1_ACACA-ADAM9_ACACA_chr17_35687113_ENST00000416895_ADAM9_chr8_38865405_ENST00000466936_length(transcript)=2581nt_BP=820nt
GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG
ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC
CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG
GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT
TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC
AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGGTCTTTCTGGAAGTGGATAT
CTACTCAGACAGTAAGAATTATAAGAGCTGTAAGAGCTCATTTTGGAGGAATAATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGC
TGAACCAGCACTCTCGATTCATAATAGGTTCTGTGTCTGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGTTGGACCTACTGG
AGGAGAAGGAGGGCTCCTTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCTGATTTGGGGATCTCTAGCCTACAGGATGGCTTGGCCT
TGCACATAAGGCTTTCAACAGACCTCACATCTTTCTTCTTATGAAATTATAACTCCTTGGAGATTAACTAGAGAAAGAAGAGAAGCCCCT
AGGCCCTATTCAAAACAAGTATCTTATGTTATTCAGGCTGAAGGAAAAGAGCATATTATTCACTTGGAAAGGAACAAAGACCTTTTGCCT
GAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGACTTTAATCACTGACCATCCCAATATACAGAGGTGTGGTCCTCTCTGCATCAGA
GAACAGAGTACTCCTGGGGACAGAGCTGGCCAGAATACCCAAAATAATTGGCAGATGTCAAATTTGGCTTTCTGTGTTTATTACTAGAGC
ATAAACATTTCTAGTTTTGTTTGAGTGTTTTACAGTCCTTTTTGGCAGTTAGGTATTATACCTTTTTTTCTTTTGCAATGGTTTTCATGA
GAAATCTTTATTCCCATTACATGTGTATGTTTTATTTTTCTTCTGAACTTTGTAATACTTTGCTATGTTGAATTGTTTCTGTTGGTAGCG
CACTTTTGCAGCATTCTTCAAATAGGAGGCAAAAAAATCTTTAGATTAATTATTAGTACTTACAAAAACCAAGGAAATGCTGACTTAGGC
CTATCTTCTGGTCCACTATCTGATTTCTTTATCTTAGTGTGTTGTTGGTCCATTGTTTAATAGAAAATTAGTAGAGGAGTTTGAATTTAC
CTTACAGCATAAACCAGATAGAAAATAACGCATTCATCCAGTCATGCATCCAATGATTACCAAGGCAGAAGGCCAAACACCACATAATTT
GTGTCACTTGACAAAAGCAGTAATGTTAAAAGGCATTTTTTTCCTCATAGAGGTTTCTTGGCATACTTTCTTCAGACATACACTGTTTGG
GCTTGAGTTTTGACTCATTATTTGCTGATGAAGCTACTTTAATCTGTTTGTGCCTTGGTATCTTCGCTTTAAAATGTAATAATAGTTACC
ACTTTATGGATATACTGGGAAACTTAACTGAGTTAATACTTACAAGATGCTTAGAACAGTCTGACAATTTTTAACTCAACGAATGTTATT
ATTTGTTGCTATTATTGACAGCGTATGTTCTTAAAACTGCCAAAAATTGATTTAATTATATAGAAACTTATGTAACTATTATCTTATATA
ATACTTAAGTATCATAAGTATGATAGAGTTATGCTTTTCTGGGTGTTTGAAAAATGTCAACTAAGACAGATGGTGTCTCACTTATTTCTT
GGTTATTTAATATTGTTCAGTTAGATGAAAGTGTGATTGTAGATTTGAAATACAAAATAAAACTTGGATACTGTGATTTTTTTAACATGG
CCAGACTGTCATGTATTATAATGACATATACTTTTGTCCATAAAATGAAATTAAGTTTCACTGAAAAATTTACATACTTTCCCCTGGGGA
TTCTATTGCTTCAGATTAAAGTTTATAAAGTATCATTAGTGTCTTCCACAGGGTCATTTTACACAAACACAGTTTTAGTGAGATGTCAAC
TGGCTTTTGTTGGTTGTTGGATTGACTGTGATTTAAAATGTTAAAGATGATATAATGCATCTTGTTCTGCTTCTAGGCTGAAAGGTCACT
GAGGCAGAGCTGTTTGTACCTTGTATCCCCTGGAATTTTGCCTAAACATTTGTGTACTCATAGGGTGGTAGGAGATAGTCCGCAGATGGT
CTAAAGAATGCCATGTGATACTGTGAGATGCCAATAATATAAATAAAACTTTGTTATTATT

>1135_1135_1_ACACA-ADAM9_ACACA_chr17_35687113_ENST00000416895_ADAM9_chr8_38865405_ENST00000466936_length(amino acids)=130AA_BP=
MRRNDERMWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKE
GSLSPASVGSDTLSDLGISSLQDGLALHIRLSTDLTSFFL

--------------------------------------------------------------
>1135_1135_2_ACACA-ADAM9_ACACA_chr17_35687113_ENST00000416895_ADAM9_chr8_38865405_ENST00000481513_length(transcript)=3032nt_BP=820nt
GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG
ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC
CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG
GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT
TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC
AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGGTCTTTCTGGAAGTGGATAT
CTACTCAGACAGTAAGAATTATAAGAGCTGTAAGAGCTCATTTTGGAGGAATAATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGC
TGAACCAGCACTCTCGATTCATAATAGGTTCTGTGTCTGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGTTGGACCTACTGG
AGGAGAAGGAGGGCTCCTTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCTGATTTGGGGATCTCTAGCCTACAGGATGGCTTGGCCT
TGCACATAAGGCTTTCAACAGACCTCACATCTTTCTTCTTATGAAATTATAACTCCTTGGAGATTAACTAGAGAAAGAAGAGAAGCCCCT
AGGCCCTATTCAAAACAAGTATCTTATGTTATTCAGGCTGAAGGAAAAGAGCATATTATTCACTTGGAAAGGAACAAAGACCTTTTGCCT
GAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGACTTTAATCACTGACCATCCCAATATACAGGTAATGTATTTTTCTCTTGATCCC
ATAGCAAATTTTAAAACAATTATAATTTAAAAATGAGTTCTGTATAGGCACTCAGGACTGTTACATTGCACAGCCCCACAGGGTACCTTT
AACATTATAACATATGGGTTATCTTGGGAAAAGTGGGTGCATTTCTATAGACTAAGCTGTACCTTACAGCTCTCCAGGTACTCAGTAGTT
AAGGTTTTTTTTTTAAAGACTAGGAAAATAAATCTTCTATTTAATGGTAATCCTTACTGATGAGAAAATTTGATATGTTTTGAAAATAGG
AGTTTCTGATTTTTTTGTTGAAAGTTAATATCTCTAAAAGTGCACTTATTAAAACATTTAATTTGTCAGTGATATTTAGTAAAGAAAAAC
ACTCATTTGATGTTATGTGTTCTAATGTTCTAAATTTTTTCTGAAAATAATTGTTTCCTAAAAGAGGTGTGGTCCTCTCTGCATCAGAGA
ACAGAGTACTCCTGGGGACAGAGCTGGCCAGAATACCCAAAATAATTGGCAGATGTCAAATTTGGCTTTCTGTGTTTATTACTAGAGCAT
AAACATTTCTAGTTTTGTTTGAGTGTTTTACAGTCCTTTTTGGCAGTTAGGTATTATACCTTTTTTTCTTTTGCAATGGTTTTCATGAGA
AATCTTTATTCCCATTACATGTGTATGTTTTATTTTTCTTCTGAACTTTGTAATACTTTGCTATGTTGAATTGTTTCTGTTGGTAGCGCA
CTTTTGCAGCATTCTTCAAATAGGAGGCAAAAAAATCTTTAGATTAATTATTAGTACTTACAAAAACCAAGGAAATGCTGACTTAGGCCT
ATCTTCTGGTCCACTATCTGATTTCTTTATCTTAGTGTGTTGTTGGTCCATTGTTTAATAGAAAATTAGTAGAGGAGTTTGAATTTACCT
TACAGCATAAACCAGATAGAAAATAACGCATTCATCCAGTCATGCATCCAATGATTACCAAGGCAGAAGGCCAAACACCACATAATTTGT
GTCACTTGACAAAAGCAGTAATGTTAAAAGGCATTTTTTTCCTCATAGAGGTTTCTTGGCATACTTTCTTCAGACATACACTGTTTGGGC
TTGAGTTTTGACTCATTATTTGCTGATGAAGCTACTTTAATCTGTTTGTGCCTTGGTATCTTCGCTTTAAAATGTAATAATAGTTACCAC
TTTATGGATATACTGGGAAACTTAACTGAGTTAATACTTACAAGATGCTTAGAACAGTCTGACAATTTTTAACTCAACGAATGTTATTAT
TTGTTGCTATTATTGACAGCGTATGTTCTTAAAACTGCCAAAAATTGATTTAATTATATAGAAACTTATGTAACTATTATCTTATATAAT
ACTTAAGTATCATAAGTATGATAGAGTTATGCTTTTCTGGGTGTTTGAAAAATGTCAACTAAGACAGATGGTGTCTCACTTATTTCTTGG
TTATTTAATATTGTTCAGTTAGATGAAAGTGTGATTGTAGATTTGAAATACAAAATAAAACTTGGATACTGTGATTTTTTTAACATGGCC
AGACTGTCATGTATTATAATGACATATACTTTTGTCCATAAAATGAAATTAAGTTTCACTGAAAAATTTACATACTTTCCCCTGGGGATT
CTATTGCTTCAGATTAAAGTTTATAAAGTATCATTAGTGTCTTCCACAGGGTCATTTTACACAAACACAGTTTTAGTGAGATGTCAACTG
GCTTTTGTTGGTTGTTGGATTGACTGTGATTTAAAATGTTAAAGATGATATAATGCATCTTGTTCTGCTTCTAGGCTGAAAGGTCACTGA
GGCAGAGCTGTTTGTACCTTGTATCCCCTGGAATTTTGCCTAAACATTTGTGTACTCATAGGGTGGTAGGAGATAGTCCGCAGATGGTCT
AAAGAATGCCATGTGATACTGTGAGATGCCAATAATATAAATAAAACTTTGTTATTATTAAA

>1135_1135_2_ACACA-ADAM9_ACACA_chr17_35687113_ENST00000416895_ADAM9_chr8_38865405_ENST00000481513_length(amino acids)=130AA_BP=
MRRNDERMWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKE
GSLSPASVGSDTLSDLGISSLQDGLALHIRLSTDLTSFFL

--------------------------------------------------------------
>1135_1135_3_ACACA-ADAM9_ACACA_chr17_35687113_ENST00000416895_ADAM9_chr8_38865405_ENST00000487273_length(transcript)=4484nt_BP=820nt
GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG
ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC
CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG
GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT
TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC
AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGGTCTTTCTGGAAGTGGATAT
CTACTCAGACAGTAAGAATTATAAGAGCTGTAAGAGCTCATTTTGGAGGAATAATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGC
TGAACCAGCACTCTCGATTCATAATAGGTTCTGTGTCTGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGTTGGACCTACTGG
AGGAGAAGGAGGGCTCCTTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCTGATTTGGGGATCTCTAGCCTACAGGATGGCTTGGCCT
TGCACATAAGGCTTTCAACAGACCTCACATCTTTCTTCTTATGAAATTATAACTCCTTGGAGATTAACTAGAGAAAGAAGAGAAGCCCCT
AGGCCCTATTCAAAACAAGTATCTTATGTTATTCAGGCTGAAGGAAAAGAGCATATTATTCACTTGGAAAGGAACAAAGACCTTTTGCCT
GAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGACTTTAATCACTGACCATCCCAATATACAGAATCATTGTCATTATCGGGGCTAT
GTGGAGGGAGTTCATAATTCATCCATTGCTCTTAGCGACTGTTTTGGACTCAGAGGATTGCTGCATTTAGAGAATGCGAGTTATGGGATT
GAACCCCTGCAGAACAGCTCTCATTTTGAGCACATCATTTATCGAATGGATGATGTCTACAAAGAGCCTCTGAAATGTGGAGTTTCCAAC
AAGGATATAGAGAAAGAAACTGCAAAGGATGAAGAGGAAGAGCCTCCCAGCATGACTCAGCTACTTCGAAGAAGAAGAGCTGTCTTGCCA
CAGACCCGGTATGTGGAGCTGTTCATTGTCGTAGACAAGGAAAGGTATGACATGATGGGAAGAAATCAGACTGCTGTGAGAGAAGAGATG
ATTCTCCTGGCAAACTACTTGGATAGTATGTATATTATGTTAAATATTCGAATTGTGCTAGTTGGACTGGAGATTTGGACCAATGGAAAC
CTGATCAACATAGTTGGGGGTGCTGGTGATGTGCTGGGGAACTTCGTGCAGTGGCGGGAAAAGTTTCTTATCACACGTCGGAGACATGAC
AGTGCACAGCTAGTTCTAAAGAAAGGTTTTGGTGGAACTGCAGGAATGGCATTTGTGGGAACAGTGTGTTCAAGGAGCCACGCAGGCGGG
ATTAATGTGTTTGGACAAATCACTGTGGAGACATTTGCTTCCATTGTTGCTCATGAATTGGGTCATAATCTTGGAATGAATCACGATGAT
GGGAGAGATTGTTCCTGTGGAGCAAAGAGCTGCATCATGAATTCAGGAGCATCGGGTTCCAGAAACTTTAGCAGTTGCAGTGCAGAGGAC
TTTGAGAAGTTAACTTTAAATAAAGGAGGAAACTGCCTTCTTAATATTCCAAAGCCTGATGAAGCCTATAGTGCTCCCTCCTGTGGTAAT
AAGTTGGTGGACGCTGGGGAAGAGTGTGACTGTGGTACTCCAAAGGAATGTGAATTGGACCCTTGCTGCGAAGGAAGTACCTGTAAGCTT
AAATCATTTGCTGAGTGTGCATATGGTGACTGTTGTAAAGACTGTCGGTTCCTTCCAGGAGGTACTTTATGCCGAGGAAAAACCAGTGAG
TGTGATGTTCCAGAGTACTGCAATGGTTCTTCTCAGTTCTGTCAGCCAGATGTTTTTATTCAGAATGGATATCCTTGCCAGAATAACAAA
GCCTATTGCTACAACGGCATGTGCCAGTATTATGATGCTCAATGTCAAGTCATCTTTGGCTCAAAAGCCAAGGCTGCCCCCAAAGATTGT
TTCATTGAAGTGAATTCTAAAGGTGACAGATTTGGCAATTGTGGTTTCTCTGGCAATGAATACAAGAAGTGTGCCACTGGGAATGCTTTG
TGTGGAAAGCTTCAGTGTGAGAATGTACAAGAGATACCTGTATTTGGAATTGTGCCTGCTATTATTCAAACGCCTAGTCGAGGCACCAAA
TGTTGGGGTGTGGATTTCCAGCTAGGATCAGATGTTCCAGATCCTGGGATGGTTAACGAAGGCACAAAATGTGGTGCTGGAAAGATCTGT
AGAAACTTCCAGTGTGTAGATGCTTCTGTTCTGAATTATGACTGTGATGTTCAGAAAAAGTGTCATGGACATGGGGTATGTAATAGCAAT
AAGAATTGTCACTGTGAAAATGGCTGGGCTCCCCCAAATTGTGAGACTAAAGGATACGGAGGAAGTGTGGACAGTGGACCTACATACAAT
GAAATGAATACTGCATTGAGGGACGGACTTCTGGTCTTCTTCTTCCTAATTGTTCCCCTTATTGTCTGTGCTATTTTTATCTTCATCAAG
AGGGATCAACTGTGGAGAAGCTACTTCAGAAAGAAGAGATCACAAACATATGAGTCAGATGGCAAAAATCAAGCAAACCCTTCTAGACAG
CCGGGGAGTGTTCCTCGACATGTTTCTCCAGTGACACCTCCCAGAGAAGTTCCTATATATGCAAACAGATTTGCAGTACCAACCTATGCA
GCCAAGCAACCTCAGCAGTTCCCATCAAGGCCACCTCCACCACAACCGAAAGTATCATCTCAGGGAAACTTAATTCCTGCCCGTCCTGCT
CCTGCACCTCCTTTATATAGTTCCCTCACTTGATTTTTTTAACCTTCTTTTTGCAAATGTCTTCAGGGAACTGAGCTAATACTTTTTTTT
TTTCTTGATGTTTTCTTGAAAAGCCTTTCTGTTGCAACTATGAATGAAAACAAAACACCACAAAACAGACTTCACTAACACAGAAAAACA
GAAACTGAGTGTGAGAGTTGTGAAATACAAGGAAATGCAGTAAAGCCAGGGAATTTACAATAACATTTCCGTTTCCATCATTGAATAAGT
CTTATTCAGTCATCGGTGAGGTTAATGCACTAATCATGGATTTTTTGAACATGTTATTGCAGTGATTCTCAAATTAACTGTATTGGTGTA
AGAGTTTTGTCATTAAGTGTTTAAGTGTTATTCTGAATTTTCTACCTTAGTTATCATTAATGTAGTTCCTCATTGAACATGTGATAATCT
AATACCTGTGAAAACTGACTAATCAGCTGCCAATAATATCTAATATTTTTCATCATGCACGAATTAATAATCATCATACTCTAGAATCTT
GTCTGTCACTCACTACATGAATAAGCAAATATTGTCTTCAAAAGAATGCACAAGAACCACAATTAAGATGTCATATTATTTTGAAAGTAC
AAAATATACTAAAAGAGTGTGTGTGTATTCACGCAGTTACTCGCTTCCATTTTTATGACCTTTCAACTATAGGTAATAACTCTTAGAGAA
ATTAATTTAATATTAGAATTTCTATTATGAATCATGTGAAAGCATGACATTCGTTCACAATAGCACTATTTTAAATAAATTATAAGCTTT
AAGGTACGAAGTATTTAATAGATCTAATCAAATATGTTGATTCATGGCTATAATAAAGCAGGAGCAATTATAAAATCTTCAATCAATTGA
ACTTTTACAAAACCACTTGAGAATTTCATGAGCACTTTAAAATCTGAACTTTCAAAGCTTGCTATTAAATCATTTAGAATGTTTACATTT
ACTAAGGTGTGCTGGGTCATGTAAAATATTAGACACTAATATTTTCATAGAAATTAGGCTGGAGAAAGAAGGAAGAAATGGTTTTCTTAA
ATACCTACAAAAAAGTTACTGTGGTATCTATGAGTTATCATCTTAGCTGTGTTAAAAATGAATTTTTACTATGGCAGATATGGTATGGAT
CGTAAAATTTTAAGCACTAAAAATTTTTTCATAACCTTTCATAATAAAGTTTAATAATAGGTTTATTAACTGAATTTCATTAGTTTTTTA
AAAGTGTTTTTGGTTTGTGTATATATACATATACAAATACAACATTTACAATAAATAAAATACTTGAAATTCTC

>1135_1135_3_ACACA-ADAM9_ACACA_chr17_35687113_ENST00000416895_ADAM9_chr8_38865405_ENST00000487273_length(amino acids)=739AA_BP=
MERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYK
EPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLV
GLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELG
HNLGMNHDDGRDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDP
CCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGS
KAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEG
TKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLI
VCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQ
GNLIPARPAPAPPLYSSLT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACACA-ADAM9

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ACACA-ADAM9

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ACACA-ADAM9

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ACACA	C0018801	Heart failure	1	CTD_human
Hgene	ACACA	C0018802	Congestive heart failure	1	CTD_human
Hgene	ACACA	C0023212	Left-Sided Heart Failure	1	CTD_human
Hgene	ACACA	C0235527	Heart Failure, Right-Sided	1	CTD_human
Hgene	ACACA	C1959583	Myocardial Failure	1	CTD_human
Hgene	ACACA	C1961112	Heart Decompensation	1	CTD_human
Hgene	ACACA	C2239176	Liver carcinoma	1	CTD_human
Tgene		C0015397	Disorder of eye	1	GENOMICS_ENGLAND
Tgene		C0033578	Prostatic Neoplasms	1	CTD_human
Tgene		C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene		C1423873	CONE-ROD DYSTROPHY 9	1	CTD_human;GENOMICS_ENGLAND
Tgene		C3489532	Cone-Rod Dystrophy 2	1	ORPHANET

Fusion Gene Studies in Kim Lab

Fusion gene:ACACA-ADAM9 (FusionGDB2 ID:HG31TG8754)

Fusion Gene Summary for ACACA-ADAM9

Fusion Gene ORF analysis for ACACA-ADAM9

Fusion Genomic Features for ACACA-ADAM9

Fusion Protein Features for ACACA-ADAM9

Fusion Gene Sequence for ACACA-ADAM9

Fusion Gene PPI Analysis for ACACA-ADAM9

Related Drugs for ACACA-ADAM9

Related Diseases for ACACA-ADAM9

Fusion Gene Studies
in Kim Lab