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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APC-DTWD2 (FusionGDB2 ID:HG324TG285605)

Fusion Gene Summary for APC-DTWD2

check button Fusion gene summary
Fusion gene informationFusion gene name: APC-DTWD2
Fusion gene ID: hg324tg285605
HgeneTgene
Gene symbol

APC

DTWD2

Gene ID

324

285605

Gene nameAPC regulator of WNT signaling pathwayDTW domain containing 2
SynonymsBTPS2|DESMD|DP2|DP2.5|DP3|GS|PPP1R46-
Cytomap('APC')('DTWD2')

5q22.2

5q23.1

Type of geneprotein-codingprotein-coding
Descriptionadenomatous polyposis coli proteinAPC, WNT signaling pathway regulatorWNT signaling pathway regulatoradenomatosis polyposis coli tumor suppressoradenomatous polyposis coli (APC)deleted in polyposis 2.5epididymis secretory sperm binding proteinproteDTW domain-containing protein 2
Modification date2020032920200313
UniProtAcc.

Q8NBA8

Ensembl transtripts involved in fusion geneENST00000257430, ENST00000457016, 
ENST00000508376, ENST00000505350, 
Fusion gene scores* DoF score14 X 10 X 8=11209 X 7 X 5=315
# samples 1410
** MAII scorelog2(14/1120*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/315*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APC [Title/Abstract] AND DTWD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPC(112164669)-DTWD2(118183913), # samples:3
Anticipated loss of major functional domain due to fusion event.APC-DTWD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APC-DTWD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPC

GO:0006974

cellular response to DNA damage stimulus

14728717

HgeneAPC

GO:0007026

negative regulation of microtubule depolymerization

11166179

HgeneAPC

GO:0007050

cell cycle arrest

8521819

HgeneAPC

GO:0008285

negative regulation of cell proliferation

8521819

HgeneAPC

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

8521819

HgeneAPC

GO:0065003

protein-containing complex assembly

16188939


check buttonFusion gene breakpoints across APC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DTWD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-EQ-A4SO-01AAPCchr5

112164669

+DTWD2chr5

118183913

-
ChimerDB4STADTCGA-EQ-A4SOAPCchr5

112164669

+DTWD2chr5

118183913

-


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Fusion Gene ORF analysis for APC-DTWD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000257430ENST00000304058APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000257430ENST00000510708APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000257430ENST00000515439APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000457016ENST00000304058APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000457016ENST00000510708APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000457016ENST00000515439APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000508376ENST00000304058APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000508376ENST00000510708APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000508376ENST00000515439APCchr5

112164669

+DTWD2chr5

118183913

-
intron-3CDSENST00000505350ENST00000304058APCchr5

112164669

+DTWD2chr5

118183913

-
intron-3CDSENST00000505350ENST00000510708APCchr5

112164669

+DTWD2chr5

118183913

-
intron-3CDSENST00000505350ENST00000515439APCchr5

112164669

+DTWD2chr5

118183913

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000457016APCchr5112164669+ENST00000304058DTWD2chr5118183913-601821233802422680
ENST00000457016APCchr5112164669+ENST00000510708DTWD2chr5118183913-379921233802422680
ENST00000457016APCchr5112164669+ENST00000515439DTWD2chr5118183913-306121233802422680
ENST00000257430APCchr5112164669+ENST00000304058DTWD2chr5118183913-56941799562098680
ENST00000257430APCchr5112164669+ENST00000510708DTWD2chr5118183913-34751799562098680
ENST00000257430APCchr5112164669+ENST00000515439DTWD2chr5118183913-27371799562098680
ENST00000508376APCchr5112164669+ENST00000304058DTWD2chr5118183913-579519001572199680
ENST00000508376APCchr5112164669+ENST00000510708DTWD2chr5118183913-357619001572199680
ENST00000508376APCchr5112164669+ENST00000515439DTWD2chr5118183913-283819001572199680

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000457016ENST00000304058APCchr5112164669+DTWD2chr5118183913-0.0003167560.99968326
ENST00000457016ENST00000510708APCchr5112164669+DTWD2chr5118183913-0.0007861540.9992138
ENST00000457016ENST00000515439APCchr5112164669+DTWD2chr5118183913-0.0020606640.9979393
ENST00000257430ENST00000304058APCchr5112164669+DTWD2chr5118183913-0.0002851150.9997149
ENST00000257430ENST00000510708APCchr5112164669+DTWD2chr5118183913-0.0006010480.99939895
ENST00000257430ENST00000515439APCchr5112164669+DTWD2chr5118183913-0.0013914670.9986085
ENST00000508376ENST00000304058APCchr5112164669+DTWD2chr5118183913-0.0003027920.9996972
ENST00000508376ENST00000510708APCchr5112164669+DTWD2chr5118183913-0.0006589580.9993411
ENST00000508376ENST00000515439APCchr5112164669+DTWD2chr5118183913-0.0015431820.99845684

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Fusion Genomic Features for APC-DTWD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for APC-DTWD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:112164669/chr5:118183913)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DTWD2

Q8NBA8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)) (PubMed:31804502). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)) (PubMed:31804502). {ECO:0000269|PubMed:31804502}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416127_2485812844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+14162_615812844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416127_2485812844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+14162_615812844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517127_2485812844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+15172_615812844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416453_4955812844.0RepeatNote=ARM 1
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416505_5475812844.0RepeatNote=ARM 2
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416453_4955812844.0RepeatNote=ARM 1
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416505_5475812844.0RepeatNote=ARM 2
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517453_4955812844.0RepeatNote=ARM 1
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517505_5475812844.0RepeatNote=ARM 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+14161131_11565812844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+14161558_15775812844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+14161_7305812844.0Compositional biasNote=Leu-rich
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416731_28325812844.0Compositional biasNote=Ser-rich
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+14161131_11565812844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+14161558_15775812844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+14161_7305812844.0Compositional biasNote=Leu-rich
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416731_28325812844.0Compositional biasNote=Ser-rich
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+15171131_11565812844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+15171558_15775812844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+15171_7305812844.0Compositional biasNote=Leu-rich
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517731_28325812844.0Compositional biasNote=Ser-rich
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+14162803_28065812844.0MotifNote=Microtubule tip localization signal
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+14162841_28435812844.0MotifNote=PDZ-binding
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+14162803_28065812844.0MotifNote=Microtubule tip localization signal
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+14162841_28435812844.0MotifNote=PDZ-binding
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+15172803_28065812844.0MotifNote=Microtubule tip localization signal
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+15172841_28435812844.0MotifNote=PDZ-binding
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+14161866_18935812844.0RegionNote=Highly charged
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416960_13375812844.0RegionNote=Responsible for down-regulation through a process mediated by direct ubiquitination
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+14161866_18935812844.0RegionNote=Highly charged
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416960_13375812844.0RegionNote=Responsible for down-regulation through a process mediated by direct ubiquitination
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+15171866_18935812844.0RegionNote=Highly charged
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517960_13375812844.0RegionNote=Responsible for down-regulation through a process mediated by direct ubiquitination
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416548_5915812844.0RepeatNote=ARM 3
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416592_6385812844.0RepeatNote=ARM 4
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416639_6835812844.0RepeatNote=ARM 5
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416684_7255812844.0RepeatNote=ARM 6
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416726_7675812844.0RepeatNote=ARM 7
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416548_5915812844.0RepeatNote=ARM 3
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416592_6385812844.0RepeatNote=ARM 4
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416639_6835812844.0RepeatNote=ARM 5
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416684_7255812844.0RepeatNote=ARM 6
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416726_7675812844.0RepeatNote=ARM 7
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517548_5915812844.0RepeatNote=ARM 3
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517592_6385812844.0RepeatNote=ARM 4
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517639_6835812844.0RepeatNote=ARM 5
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517684_7255812844.0RepeatNote=ARM 6
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517726_7675812844.0RepeatNote=ARM 7
TgeneDTWD2chr5:112164669chr5:118183913ENST0000051070836178_181199299.0MotifNote=DXTW


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Fusion Gene Sequence for APC-DTWD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5380_5380_1_APC-DTWD2_APC_chr5_112164669_ENST00000257430_DTWD2_chr5_118183913_ENST00000304058_length(transcript)=5694nt_BP=1799nt
GGAGACAGAATGGAGGTGCTGCCGGACTCGGAAATGGGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGC
AAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCAT
CTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTC
TTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGAT
CTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTG
GATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAAC
TTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATG
AAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTC
AGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAA
CCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTA
CACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGG
TGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAG
ACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAA
ATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGC
GTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGG
ACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGC
ATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACC
ACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTA
TGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGT
CTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGG
TGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTG
CTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTG
CCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGG
AATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTT
CATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATT
CATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATG
TTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATT
GGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTA
CAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGT
ATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGA
AATAGCACACATTTTCATTTGTAATCACTCTGGATAAATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCTGGTAAACTTAT
TTTATTGATGTTTTCATATGGAAAATAATAAGTGGAATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCTATTTAATATAA
CCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAAAAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTGTATAGAATAAG
AGACATGTATGTAACATATATGTATATTCAGCACAAGTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATTTTGTTTAGTCT
TTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGTTAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACTTGGTAACTATT
TATAGAGCATACACCAATGATTATTTCTCACAGTTTTCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAAAAGGTATAATG
CTGGTCACAATTAGAATGCTAATATTTGGGGAAACTATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTATTGTTGATTTA
TTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCATTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGTGAGAATTGCTT
GAGCCCAGGAGTTTGAGACCAGCCTGGGCAATATGGTGAGACTCCATCTCCATACAAAATTAAAAAAAAAATAATTAGCCAGATGTGGTG
GTGTGCACTTGTAGTCCTAGCTACTTGGGAGGCTAAGGTGGGAGGATCGCTGGAGCCCAGGACATCAAGGTTGCAAGGAGCTATGTTCAT
TCCACTGCACTCCAGCCTGGGCTACAGAGTGAGACCTGTCTAAAATAAATAAATAAATAAACAAACTAGCTCATTTACAATGTAAAGCAC
TTAATATCAAATGATTATTTGGTGTACTAGAAAAGAAACAGCATATAATAATGTATAATAGTTTCTTAACAAGTGGGGCTAAAATCATTT
TGTAGTAATTTTTCACATTGATATTAAACTTCATGAGTTTCTTTTAGTCATTATTATTATTATTATTATTATTTGAGATGGAATCTCGCT
CTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTTGGCTCACTGAAAGCTCTGCCTCCTGGGTTCACGCCATTCTTCTGCCTCAGCCTCC
TGAGTAGCTGGGACTACAGGTGCCCACCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTATTAGCCAGGA
TGGTCTCGATCTCCTGACCTCGTGATCTGTCTGCCTTGGCCTCCAAAAGTGCTGGGACCGTGCCCAGCCATCATTATTATTTTTTAAAAA
GAAAACTCCCCCTACCCCCAGTATACCATTTTGTATCTCAAAATTTTACTTTATTGATTTTTAAGAGTAATTTCTACTTTTATCTTTTAA
ATAAAACATTTTAGAGTATTTTTGAAGACTTAAAAAGCTTAAAATTTAGTGTTTTTGGAAATGTATAAAATTTTCTTGAAGTATGTATAG
TTTTCCAAATTACTTTACTGACCTGTTAACTCACTGTACTTGTTTTTTACTTATTTTTTCCTGACCTCTTAACAAGGTGAGTCCATTTAA
TCATCTGTGGTATAAAATGCTTCTCTAGTCACCTGTTCTCATTAAACAGTTGTAAGTAAGTTTTAAAAGCCATTATTTTAATTACTAAAA
GTTCTCAAGTGTGTAGTATTATCTGAGTATTTTAATTGAAAAATTAATCAGGCTTTTAAAAATTACTTTTTTATTGTATTAGTTGGCTTT
TAAATTCAGATTCTTTATATTTGCTTGATTTTTCCTGGAAGTTCCAAGTTTTATGAATTTGTAGCTGATAGTAGGTTTTACTTGTGTACC
CCATCTGCACTTTGATGTTGTGTAGATCGTTTTGTGAGTTATTTGAACCGTGTAACTCAGAGAATAGTATTTCCTCATACATAAAGTGAC
CTCACTTTTAATCAGCTCCTTTATAGTATGTTGAAAATCACTGCGTGTAATGAGAGGTATTGAGAGTTTCTTGCACACATGAGTGTAAAA
GGTTGAGAACTAGATTATACAAAGTAGTAAGTCACAGTGCATGGCAACTTTCTACAGGTTGGATTATAAGACTTATGTGGAATAGGAGAA
TTATATTGGGAAAAAATTATTTTCTCTAACTTGAAGACTCCAGAGACACTTTTCTTAGTCATGACCAGTAATATTTTTCATATATTTTGG
AAGAAATAAGCTCCTCACTATACCACCAGTTAGTGATTTATTTATTTATGTATTTTAGAGACAGGGCCTCCTTCTGTCACCCAGTTTGGA
GTGCAGTGGTGTAATCATAGCTTACTGCAGCATCAAACTCCTGGGCTCAAGTGTTCCTCCTGCCTCAGCCTCCCAAGTAGCTAGAACCTC
AGCCCCATGCCACCACACTCAGCTAATTTTAAATTTTACTAATTTCATTTAATTTTTGTGGAGATGGGGGTCTTGCTGTGTTGTTTAGGC
TGGTCCTGAACTCCTGGCCTCAAGCGATCCTTCTGCCTTGGCCTCTCAGTAAATTATATAGAAGAGCACTTCTGTATAATTTACTCAGTT
TCTTCATCACATATTTCCAACTGTTGCCCTAAATAGGTTTAAAAATGTGATCATGTTATTAGAAAATCCTTTCCATTGAATTTCAGGGAT
GCTGAATTTCAGGGAGCTAAATTGTTGACCCTTGCCTGTAGTTGTTATTGGTTCAGAAGTAAATTTTATTGATGCTACAAGTAAAAAATT
AGATCTGACTTAGTAAACTCAAAAGTTTTACAAAACTGTATTTTACTATGTAGATGTATTTCTTTAAAATAGGTATGGATGGATATTTTT

>5380_5380_1_APC-DTWD2_APC_chr5_112164669_ENST00000257430_DTWD2_chr5_118183913_ENST00000304058_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_2_APC-DTWD2_APC_chr5_112164669_ENST00000257430_DTWD2_chr5_118183913_ENST00000510708_length(transcript)=3475nt_BP=1799nt
GGAGACAGAATGGAGGTGCTGCCGGACTCGGAAATGGGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGC
AAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCAT
CTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTC
TTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGAT
CTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTG
GATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAAC
TTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATG
AAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTC
AGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAA
CCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTA
CACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGG
TGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAG
ACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAA
ATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGC
GTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGG
ACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGC
ATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACC
ACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTA
TGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGT
CTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGG
TGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTG
CTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTG
CCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGG
AATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTT
CATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATT
CATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATG
TTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATT
GGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTA
CAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGT
ATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGA
AATAGCACACATTTTCATTTGTAATCACTCTGGATAAATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCTGGTAAACTTAT
TTTATTGATGTTTTCATATGGAAAATAATAAGTGGAATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCTATTTAATATAA
CCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAAAAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTGTATAGAATAAG
AGACATGTATGTAACATATATGTATATTCAGCACAAGTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATTTTGTTTAGTCT
TTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGTTAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACTTGGTAACTATT
TATAGAGCATACACCAATGATTATTTCTCACAGTTTTCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAAAAGGTATAATG
CTGGTCACAATTAGAATGCTAATATTTGGGGAAACTATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTATTGTTGATTTA
TTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCATTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGTGAGAATTGCTT

>5380_5380_2_APC-DTWD2_APC_chr5_112164669_ENST00000257430_DTWD2_chr5_118183913_ENST00000510708_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_3_APC-DTWD2_APC_chr5_112164669_ENST00000257430_DTWD2_chr5_118183913_ENST00000515439_length(transcript)=2737nt_BP=1799nt
GGAGACAGAATGGAGGTGCTGCCGGACTCGGAAATGGGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGC
AAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCAT
CTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTC
TTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGAT
CTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTG
GATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAAC
TTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATG
AAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTC
AGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAA
CCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTA
CACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGG
TGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAG
ACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAA
ATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGC
GTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGG
ACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGC
ATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACC
ACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTA
TGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGT
CTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGG
TGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTG
CTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTG
CCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGG
AATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTT
CATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATT
CATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATG
TTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATT
GGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTA
CAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGT
ATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGA

>5380_5380_3_APC-DTWD2_APC_chr5_112164669_ENST00000257430_DTWD2_chr5_118183913_ENST00000515439_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_4_APC-DTWD2_APC_chr5_112164669_ENST00000457016_DTWD2_chr5_118183913_ENST00000304058_length(transcript)=6018nt_BP=2123nt
ACAAGATGGCGGAGGGCAAGTAGCAAGGGGGCGGGGTGTGGCCGCCGGAAGCCTAGCCGCTGCTCGGGGGGGACCTGCGGGCTCAGGCCC
GGGAGCTGCGGACCGAGGTTGGCTCGATGCTGTTCCCAGGTACTGTTGTTGGCTGTTGGTGAGGAAGGTGAAGCACTCAGTTGCCTTCTC
GGGCCTCGGCGCCCCCTATGTACGCCTCCCTGGGCTCGGGTCCGGTCGCCCCTTTGCCCGCTTCTGTACCACCCTCAGTTCTCGGGTCCT
GGAGCACCGGCGGCAGCAGGAGCTGCGTCCGGCAGGAGACGAAGAGCCCGGGCGGCGCTCGTACTTCTGGCCACTGGGCGAGCGTCTGGC
AGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTC
GACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAA
GTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTG
GAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTC
CTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGC
TTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTT
TAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAAC
TAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGC
TTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTC
AAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTT
CTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTA
CTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTC
CTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCA
GTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATAC
GCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAAC
ATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGG
CCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGG
CTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAA
AATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGC
GAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAA
TTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAG
AGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAA
ATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTT
ATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAA
AGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACT
GAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTG
TGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAAT
TAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAA
TCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATG
ATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATA
AATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCTGGTAAACTTATTTTATTGATGTTTTCATATGGAAAATAATAAGTGGA
ATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCTATTTAATATAACCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAA
AAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTGTATAGAATAAGAGACATGTATGTAACATATATGTATATTCAGCACAA
GTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATTTTGTTTAGTCTTTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGT
TAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACTTGGTAACTATTTATAGAGCATACACCAATGATTATTTCTCACAGTTT
TCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAAAAGGTATAATGCTGGTCACAATTAGAATGCTAATATTTGGGGAAACT
ATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTATTGTTGATTTATTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCAT
TAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGTGAGAATTGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAATATGG
TGAGACTCCATCTCCATACAAAATTAAAAAAAAAATAATTAGCCAGATGTGGTGGTGTGCACTTGTAGTCCTAGCTACTTGGGAGGCTAA
GGTGGGAGGATCGCTGGAGCCCAGGACATCAAGGTTGCAAGGAGCTATGTTCATTCCACTGCACTCCAGCCTGGGCTACAGAGTGAGACC
TGTCTAAAATAAATAAATAAATAAACAAACTAGCTCATTTACAATGTAAAGCACTTAATATCAAATGATTATTTGGTGTACTAGAAAAGA
AACAGCATATAATAATGTATAATAGTTTCTTAACAAGTGGGGCTAAAATCATTTTGTAGTAATTTTTCACATTGATATTAAACTTCATGA
GTTTCTTTTAGTCATTATTATTATTATTATTATTATTTGAGATGGAATCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTTG
GCTCACTGAAAGCTCTGCCTCCTGGGTTCACGCCATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCACCACCACGCC
CGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTATTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGTCTGCCT
TGGCCTCCAAAAGTGCTGGGACCGTGCCCAGCCATCATTATTATTTTTTAAAAAGAAAACTCCCCCTACCCCCAGTATACCATTTTGTAT
CTCAAAATTTTACTTTATTGATTTTTAAGAGTAATTTCTACTTTTATCTTTTAAATAAAACATTTTAGAGTATTTTTGAAGACTTAAAAA
GCTTAAAATTTAGTGTTTTTGGAAATGTATAAAATTTTCTTGAAGTATGTATAGTTTTCCAAATTACTTTACTGACCTGTTAACTCACTG
TACTTGTTTTTTACTTATTTTTTCCTGACCTCTTAACAAGGTGAGTCCATTTAATCATCTGTGGTATAAAATGCTTCTCTAGTCACCTGT
TCTCATTAAACAGTTGTAAGTAAGTTTTAAAAGCCATTATTTTAATTACTAAAAGTTCTCAAGTGTGTAGTATTATCTGAGTATTTTAAT
TGAAAAATTAATCAGGCTTTTAAAAATTACTTTTTTATTGTATTAGTTGGCTTTTAAATTCAGATTCTTTATATTTGCTTGATTTTTCCT
GGAAGTTCCAAGTTTTATGAATTTGTAGCTGATAGTAGGTTTTACTTGTGTACCCCATCTGCACTTTGATGTTGTGTAGATCGTTTTGTG
AGTTATTTGAACCGTGTAACTCAGAGAATAGTATTTCCTCATACATAAAGTGACCTCACTTTTAATCAGCTCCTTTATAGTATGTTGAAA
ATCACTGCGTGTAATGAGAGGTATTGAGAGTTTCTTGCACACATGAGTGTAAAAGGTTGAGAACTAGATTATACAAAGTAGTAAGTCACA
GTGCATGGCAACTTTCTACAGGTTGGATTATAAGACTTATGTGGAATAGGAGAATTATATTGGGAAAAAATTATTTTCTCTAACTTGAAG
ACTCCAGAGACACTTTTCTTAGTCATGACCAGTAATATTTTTCATATATTTTGGAAGAAATAAGCTCCTCACTATACCACCAGTTAGTGA
TTTATTTATTTATGTATTTTAGAGACAGGGCCTCCTTCTGTCACCCAGTTTGGAGTGCAGTGGTGTAATCATAGCTTACTGCAGCATCAA
ACTCCTGGGCTCAAGTGTTCCTCCTGCCTCAGCCTCCCAAGTAGCTAGAACCTCAGCCCCATGCCACCACACTCAGCTAATTTTAAATTT
TACTAATTTCATTTAATTTTTGTGGAGATGGGGGTCTTGCTGTGTTGTTTAGGCTGGTCCTGAACTCCTGGCCTCAAGCGATCCTTCTGC
CTTGGCCTCTCAGTAAATTATATAGAAGAGCACTTCTGTATAATTTACTCAGTTTCTTCATCACATATTTCCAACTGTTGCCCTAAATAG
GTTTAAAAATGTGATCATGTTATTAGAAAATCCTTTCCATTGAATTTCAGGGATGCTGAATTTCAGGGAGCTAAATTGTTGACCCTTGCC
TGTAGTTGTTATTGGTTCAGAAGTAAATTTTATTGATGCTACAAGTAAAAAATTAGATCTGACTTAGTAAACTCAAAAGTTTTACAAAAC

>5380_5380_4_APC-DTWD2_APC_chr5_112164669_ENST00000457016_DTWD2_chr5_118183913_ENST00000304058_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_5_APC-DTWD2_APC_chr5_112164669_ENST00000457016_DTWD2_chr5_118183913_ENST00000510708_length(transcript)=3799nt_BP=2123nt
ACAAGATGGCGGAGGGCAAGTAGCAAGGGGGCGGGGTGTGGCCGCCGGAAGCCTAGCCGCTGCTCGGGGGGGACCTGCGGGCTCAGGCCC
GGGAGCTGCGGACCGAGGTTGGCTCGATGCTGTTCCCAGGTACTGTTGTTGGCTGTTGGTGAGGAAGGTGAAGCACTCAGTTGCCTTCTC
GGGCCTCGGCGCCCCCTATGTACGCCTCCCTGGGCTCGGGTCCGGTCGCCCCTTTGCCCGCTTCTGTACCACCCTCAGTTCTCGGGTCCT
GGAGCACCGGCGGCAGCAGGAGCTGCGTCCGGCAGGAGACGAAGAGCCCGGGCGGCGCTCGTACTTCTGGCCACTGGGCGAGCGTCTGGC
AGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTC
GACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAA
GTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTG
GAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTC
CTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGC
TTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTT
TAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAAC
TAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGC
TTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTC
AAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTT
CTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTA
CTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTC
CTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCA
GTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATAC
GCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAAC
ATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGG
CCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGG
CTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAA
AATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGC
GAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAA
TTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAG
AGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAA
ATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTT
ATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAA
AGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACT
GAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTG
TGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAAT
TAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAA
TCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATG
ATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATA
AATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCTGGTAAACTTATTTTATTGATGTTTTCATATGGAAAATAATAAGTGGA
ATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCTATTTAATATAACCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAA
AAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTGTATAGAATAAGAGACATGTATGTAACATATATGTATATTCAGCACAA
GTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATTTTGTTTAGTCTTTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGT
TAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACTTGGTAACTATTTATAGAGCATACACCAATGATTATTTCTCACAGTTT
TCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAAAAGGTATAATGCTGGTCACAATTAGAATGCTAATATTTGGGGAAACT
ATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTATTGTTGATTTATTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCAT
TAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGTGAGAATTGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAATATGG

>5380_5380_5_APC-DTWD2_APC_chr5_112164669_ENST00000457016_DTWD2_chr5_118183913_ENST00000510708_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_6_APC-DTWD2_APC_chr5_112164669_ENST00000457016_DTWD2_chr5_118183913_ENST00000515439_length(transcript)=3061nt_BP=2123nt
ACAAGATGGCGGAGGGCAAGTAGCAAGGGGGCGGGGTGTGGCCGCCGGAAGCCTAGCCGCTGCTCGGGGGGGACCTGCGGGCTCAGGCCC
GGGAGCTGCGGACCGAGGTTGGCTCGATGCTGTTCCCAGGTACTGTTGTTGGCTGTTGGTGAGGAAGGTGAAGCACTCAGTTGCCTTCTC
GGGCCTCGGCGCCCCCTATGTACGCCTCCCTGGGCTCGGGTCCGGTCGCCCCTTTGCCCGCTTCTGTACCACCCTCAGTTCTCGGGTCCT
GGAGCACCGGCGGCAGCAGGAGCTGCGTCCGGCAGGAGACGAAGAGCCCGGGCGGCGCTCGTACTTCTGGCCACTGGGCGAGCGTCTGGC
AGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTC
GACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAA
GTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTG
GAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTC
CTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGC
TTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTT
TAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAAC
TAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGC
TTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTC
AAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTT
CTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTA
CTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTC
CTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCA
GTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATAC
GCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAAC
ATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGG
CCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGG
CTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAA
AATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGC
GAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAA
TTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAG
AGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAA
ATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTT
ATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAA
AGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACT
GAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTG
TGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAAT
TAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAA
TCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATG
ATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATA

>5380_5380_6_APC-DTWD2_APC_chr5_112164669_ENST00000457016_DTWD2_chr5_118183913_ENST00000515439_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_7_APC-DTWD2_APC_chr5_112164669_ENST00000508376_DTWD2_chr5_118183913_ENST00000304058_length(transcript)=5795nt_BP=1900nt
GAATGGAGGTGCTGCCGGACTCGGAAATGGGGACACATGCATTGGTGGCCAAAAGAGAGAGGAGACAAAACCGCTGCAGATGGCTGATGT
GAATCTAGTGGAAAGAGCTACTGGGGATGAGAGAAAGAGGAGGAGGCAGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCA
GTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGA
AACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTT
ATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAG
CCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAG
AGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTA
TTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCA
ATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAAT
AGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAA
CAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCA
GGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCT
GGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTC
TAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGT
ATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAA
GAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGA
ACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATT
TGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCT
TACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTAC
GCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTT
GAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGA
AGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTG
TGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACT
TCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACT
CAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCA
AATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTA
AACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCC
TCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGT
TGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAG
TCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGG
AAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCA
TGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATAAATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCT
GGTAAACTTATTTTATTGATGTTTTCATATGGAAAATAATAAGTGGAATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCT
ATTTAATATAACCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAAAAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTG
TATAGAATAAGAGACATGTATGTAACATATATGTATATTCAGCACAAGTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATT
TTGTTTAGTCTTTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGTTAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACT
TGGTAACTATTTATAGAGCATACACCAATGATTATTTCTCACAGTTTTCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAA
AAGGTATAATGCTGGTCACAATTAGAATGCTAATATTTGGGGAAACTATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTA
TTGTTGATTTATTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCATTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGT
GAGAATTGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAATATGGTGAGACTCCATCTCCATACAAAATTAAAAAAAAAATAATTAGC
CAGATGTGGTGGTGTGCACTTGTAGTCCTAGCTACTTGGGAGGCTAAGGTGGGAGGATCGCTGGAGCCCAGGACATCAAGGTTGCAAGGA
GCTATGTTCATTCCACTGCACTCCAGCCTGGGCTACAGAGTGAGACCTGTCTAAAATAAATAAATAAATAAACAAACTAGCTCATTTACA
ATGTAAAGCACTTAATATCAAATGATTATTTGGTGTACTAGAAAAGAAACAGCATATAATAATGTATAATAGTTTCTTAACAAGTGGGGC
TAAAATCATTTTGTAGTAATTTTTCACATTGATATTAAACTTCATGAGTTTCTTTTAGTCATTATTATTATTATTATTATTATTTGAGAT
GGAATCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTTGGCTCACTGAAAGCTCTGCCTCCTGGGTTCACGCCATTCTTCTG
CCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCACCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGT
ATTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGTCTGCCTTGGCCTCCAAAAGTGCTGGGACCGTGCCCAGCCATCATTATTA
TTTTTTAAAAAGAAAACTCCCCCTACCCCCAGTATACCATTTTGTATCTCAAAATTTTACTTTATTGATTTTTAAGAGTAATTTCTACTT
TTATCTTTTAAATAAAACATTTTAGAGTATTTTTGAAGACTTAAAAAGCTTAAAATTTAGTGTTTTTGGAAATGTATAAAATTTTCTTGA
AGTATGTATAGTTTTCCAAATTACTTTACTGACCTGTTAACTCACTGTACTTGTTTTTTACTTATTTTTTCCTGACCTCTTAACAAGGTG
AGTCCATTTAATCATCTGTGGTATAAAATGCTTCTCTAGTCACCTGTTCTCATTAAACAGTTGTAAGTAAGTTTTAAAAGCCATTATTTT
AATTACTAAAAGTTCTCAAGTGTGTAGTATTATCTGAGTATTTTAATTGAAAAATTAATCAGGCTTTTAAAAATTACTTTTTTATTGTAT
TAGTTGGCTTTTAAATTCAGATTCTTTATATTTGCTTGATTTTTCCTGGAAGTTCCAAGTTTTATGAATTTGTAGCTGATAGTAGGTTTT
ACTTGTGTACCCCATCTGCACTTTGATGTTGTGTAGATCGTTTTGTGAGTTATTTGAACCGTGTAACTCAGAGAATAGTATTTCCTCATA
CATAAAGTGACCTCACTTTTAATCAGCTCCTTTATAGTATGTTGAAAATCACTGCGTGTAATGAGAGGTATTGAGAGTTTCTTGCACACA
TGAGTGTAAAAGGTTGAGAACTAGATTATACAAAGTAGTAAGTCACAGTGCATGGCAACTTTCTACAGGTTGGATTATAAGACTTATGTG
GAATAGGAGAATTATATTGGGAAAAAATTATTTTCTCTAACTTGAAGACTCCAGAGACACTTTTCTTAGTCATGACCAGTAATATTTTTC
ATATATTTTGGAAGAAATAAGCTCCTCACTATACCACCAGTTAGTGATTTATTTATTTATGTATTTTAGAGACAGGGCCTCCTTCTGTCA
CCCAGTTTGGAGTGCAGTGGTGTAATCATAGCTTACTGCAGCATCAAACTCCTGGGCTCAAGTGTTCCTCCTGCCTCAGCCTCCCAAGTA
GCTAGAACCTCAGCCCCATGCCACCACACTCAGCTAATTTTAAATTTTACTAATTTCATTTAATTTTTGTGGAGATGGGGGTCTTGCTGT
GTTGTTTAGGCTGGTCCTGAACTCCTGGCCTCAAGCGATCCTTCTGCCTTGGCCTCTCAGTAAATTATATAGAAGAGCACTTCTGTATAA
TTTACTCAGTTTCTTCATCACATATTTCCAACTGTTGCCCTAAATAGGTTTAAAAATGTGATCATGTTATTAGAAAATCCTTTCCATTGA
ATTTCAGGGATGCTGAATTTCAGGGAGCTAAATTGTTGACCCTTGCCTGTAGTTGTTATTGGTTCAGAAGTAAATTTTATTGATGCTACA
AGTAAAAAATTAGATCTGACTTAGTAAACTCAAAAGTTTTACAAAACTGTATTTTACTATGTAGATGTATTTCTTTAAAATAGGTATGGA

>5380_5380_7_APC-DTWD2_APC_chr5_112164669_ENST00000508376_DTWD2_chr5_118183913_ENST00000304058_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_8_APC-DTWD2_APC_chr5_112164669_ENST00000508376_DTWD2_chr5_118183913_ENST00000510708_length(transcript)=3576nt_BP=1900nt
GAATGGAGGTGCTGCCGGACTCGGAAATGGGGACACATGCATTGGTGGCCAAAAGAGAGAGGAGACAAAACCGCTGCAGATGGCTGATGT
GAATCTAGTGGAAAGAGCTACTGGGGATGAGAGAAAGAGGAGGAGGCAGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCA
GTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGA
AACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTT
ATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAG
CCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAG
AGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTA
TTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCA
ATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAAT
AGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAA
CAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCA
GGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCT
GGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTC
TAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGT
ATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAA
GAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGA
ACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATT
TGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCT
TACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTAC
GCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTT
GAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGA
AGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTG
TGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACT
TCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACT
CAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCA
AATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTA
AACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCC
TCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGT
TGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAG
TCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGG
AAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCA
TGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATAAATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCT
GGTAAACTTATTTTATTGATGTTTTCATATGGAAAATAATAAGTGGAATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCT
ATTTAATATAACCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAAAAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTG
TATAGAATAAGAGACATGTATGTAACATATATGTATATTCAGCACAAGTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATT
TTGTTTAGTCTTTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGTTAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACT
TGGTAACTATTTATAGAGCATACACCAATGATTATTTCTCACAGTTTTCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAA
AAGGTATAATGCTGGTCACAATTAGAATGCTAATATTTGGGGAAACTATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTA
TTGTTGATTTATTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCATTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGT

>5380_5380_8_APC-DTWD2_APC_chr5_112164669_ENST00000508376_DTWD2_chr5_118183913_ENST00000510708_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

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>5380_5380_9_APC-DTWD2_APC_chr5_112164669_ENST00000508376_DTWD2_chr5_118183913_ENST00000515439_length(transcript)=2838nt_BP=1900nt
GAATGGAGGTGCTGCCGGACTCGGAAATGGGGACACATGCATTGGTGGCCAAAAGAGAGAGGAGACAAAACCGCTGCAGATGGCTGATGT
GAATCTAGTGGAAAGAGCTACTGGGGATGAGAGAAAGAGGAGGAGGCAGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCA
GTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGA
AACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTT
ATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAG
CCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAG
AGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTA
TTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCA
ATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAAT
AGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAA
CAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCA
GGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCT
GGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTC
TAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGT
ATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAA
GAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGA
ACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATT
TGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCT
TACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTAC
GCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTT
GAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGA
AGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTG
TGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACT
TCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACT
CAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCA
AATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTA
AACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCC
TCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGT
TGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAG
TCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGG
AAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCA

>5380_5380_9_APC-DTWD2_APC_chr5_112164669_ENST00000508376_DTWD2_chr5_118183913_ENST00000515439_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

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Top

Fusion Gene PPI Analysis for APC-DTWD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for APC-DTWD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for APC-DTWD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPCC0032580Adenomatous Polyposis Coli24CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneAPCC2713442Polyposis, Adenomatous Intestinal11CTD_human
HgeneAPCC2713443Familial Intestinal Polyposis11CTD_human
HgeneAPCC0007102Malignant tumor of colon7CTD_human
HgeneAPCC0009375Colonic Neoplasms7CTD_human
HgeneAPCC0009402Colorectal Carcinoma7CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneAPCC0009404Colorectal Neoplasms7CTD_human;UNIPROT
HgeneAPCC0021841Intestinal Neoplasms6CTD_human
HgeneAPCC0346627Intestinal Cancer6CTD_human
HgeneAPCC0001430Adenoma5CTD_human
HgeneAPCC0205646Adenoma, Basal Cell5CTD_human
HgeneAPCC0205647Follicular adenoma5CTD_human
HgeneAPCC0205648Adenoma, Microcystic5CTD_human
HgeneAPCC0205649Adenoma, Monomorphic5CTD_human
HgeneAPCC0205650Papillary adenoma5CTD_human
HgeneAPCC0205651Adenoma, Trabecular5CTD_human
HgeneAPCC0021846Intestinal Polyps3CTD_human
HgeneAPCC0001418Adenocarcinoma2CTD_human
HgeneAPCC0004352Autistic Disorder2CTD_human
HgeneAPCC0007113Rectal Carcinoma2CTD_human
HgeneAPCC0007621Neoplastic Cell Transformation2CTD_human
HgeneAPCC0025149Medulloblastoma2CTD_human;UNIPROT
HgeneAPCC0033578Prostatic Neoplasms2CTD_human
HgeneAPCC0034885Rectal Neoplasms2CTD_human
HgeneAPCC0205641Adenocarcinoma, Basal Cell2CTD_human
HgeneAPCC0205642Adenocarcinoma, Oxyphilic2CTD_human
HgeneAPCC0205643Carcinoma, Cribriform2CTD_human
HgeneAPCC0205644Carcinoma, Granular Cell2CTD_human
HgeneAPCC0205645Adenocarcinoma, Tubular2CTD_human
HgeneAPCC0376358Malignant neoplasm of prostate2CTD_human
HgeneAPCC0002886Anemia, Macrocytic1CTD_human
HgeneAPCC0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneAPCC0009405Hereditary Nonpolyposis Colorectal Neoplasms1CTD_human
HgeneAPCC0015393Eye Abnormalities1CTD_human
HgeneAPCC0017181Gastrointestinal Hemorrhage1CTD_human
HgeneAPCC0017185Gastrointestinal Neoplasms1CTD_human
HgeneAPCC0017636Glioblastoma1CTD_human
HgeneAPCC0018932Hematochezia1CTD_human
HgeneAPCC0020473Hyperlipidemia1CTD_human
HgeneAPCC0020796Profound Mental Retardation1CTD_human
HgeneAPCC0021390Inflammatory Bowel Diseases1CTD_human
HgeneAPCC0023518Leukocytosis1CTD_human
HgeneAPCC0023903Liver neoplasms1CTD_human
HgeneAPCC0024121Lung Neoplasms1CTD_human
HgeneAPCC0024667Animal Mammary Neoplasms1CTD_human
HgeneAPCC0025363Mental Retardation, Psychosocial1CTD_human
HgeneAPCC0025500Mesothelioma1CTD_human
HgeneAPCC0035222Respiratory Distress Syndrome, Adult1CTD_human
HgeneAPCC0036341Schizophrenia1PSYGENET
HgeneAPCC0038002Splenomegaly1CTD_human
HgeneAPCC0079218Fibromatosis, Aggressive1CGI;CTD_human;ORPHANET
HgeneAPCC0151857Pleocytosis1CTD_human
HgeneAPCC0205833Medullomyoblastoma1CTD_human
HgeneAPCC0206646Fibromatosis, Abdominal1CTD_human
HgeneAPCC0206677Adenomatous Polyps1CTD_human
HgeneAPCC0242379Malignant neoplasm of lung1CTD_human
HgeneAPCC0265325Turcot syndrome (disorder)1CTD_human
HgeneAPCC0278510Childhood Medulloblastoma1CTD_human
HgeneAPCC0278876Adult Medulloblastoma1CTD_human
HgeneAPCC0334588Giant Cell Glioblastoma1CTD_human
HgeneAPCC0345904Malignant neoplasm of liver1CTD_human
HgeneAPCC0685938Malignant neoplasm of gastrointestinal tract1CTD_human
HgeneAPCC0751291Desmoplastic Medulloblastoma1CTD_human
HgeneAPCC0917816Mental deficiency1CTD_human
HgeneAPCC1257925Mammary Carcinoma, Animal1CTD_human
HgeneAPCC1275668Melanotic medulloblastoma1CTD_human
HgeneAPCC1333990Hereditary Nonpolyposis Colorectal Cancer1CTD_human
HgeneAPCC1621958Glioblastoma Multiforme1CTD_human
HgeneAPCC1706412Lipidemias1CTD_human
HgeneAPCC1859309Syndactyly Cenani Lenz type1ORPHANET
HgeneAPCC1879526Aberrant Crypt Foci1CTD_human
HgeneAPCC3714756Intellectual Disability1CTD_human
HgeneAPCC4552100Lynch Syndrome1CTD_human