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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:HSD17B3-CDC14B (FusionGDB2 ID:HG3293TG8555) |
Fusion Gene Summary for HSD17B3-CDC14B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HSD17B3-CDC14B | Fusion gene ID: hg3293tg8555 | Hgene | Tgene | Gene symbol | HSD17B3 | CDC14B | Gene ID | 3293 | 8555 |
| Gene name | hydroxysteroid 17-beta dehydrogenase 3 | cell division cycle 14B | |
| Synonyms | EDH17B3|SDR12C2 | CDC14B3|Cdc14B1|Cdc14B2|hCDC14B | |
| Cytomap | ('HSD17B3')('CDC14B') 9q22.32 | 9q22.32-q22.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | testosterone 17-beta-dehydrogenase 317-beta-HSD 317-beta-HSD317-beta-hydroxysteroid dehydrogenase type 3hydroxysteroid dehydrogenase 3short chain dehydrogenase/reductase family 12C member 2testicular 17-beta-hydroxysteroid dehydrogenase | dual specificity protein phosphatase CDC14BCDC14 cell division cycle 14 homolog B | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | O60729 | |
| Ensembl transtripts involved in fusion gene | ENST00000375262, ENST00000375263, ENST00000464104, | ||
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 7 X 7 X 4=196 |
| # samples | 4 | 8 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HSD17B3 [Title/Abstract] AND CDC14B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | HSD17B3(99060698)-CDC14B(99327765), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | HSD17B3-CDC14B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HSD17B3-CDC14B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HSD17B3-CDC14B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HSD17B3-CDC14B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HSD17B3-CDC14B seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CDC14B | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint | 18662541 |
| Fusion gene breakpoints across HSD17B3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CDC14B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUAD | TCGA-L4-A4E5-01A | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
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Fusion Gene ORF analysis for HSD17B3-CDC14B |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000375262 | ENST00000481149 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| 5CDS-intron | ENST00000375263 | ENST00000481149 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| Frame-shift | ENST00000375262 | ENST00000265659 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| Frame-shift | ENST00000375262 | ENST00000375236 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| Frame-shift | ENST00000375262 | ENST00000375240 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| Frame-shift | ENST00000375262 | ENST00000375241 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| Frame-shift | ENST00000375262 | ENST00000375242 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| Frame-shift | ENST00000375263 | ENST00000265659 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| Frame-shift | ENST00000375263 | ENST00000375236 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| Frame-shift | ENST00000375263 | ENST00000375240 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| Frame-shift | ENST00000375263 | ENST00000375241 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| Frame-shift | ENST00000375263 | ENST00000375242 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| In-frame | ENST00000375262 | ENST00000463569 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| In-frame | ENST00000375263 | ENST00000463569 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| intron-3CDS | ENST00000464104 | ENST00000265659 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| intron-3CDS | ENST00000464104 | ENST00000375236 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| intron-3CDS | ENST00000464104 | ENST00000375240 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| intron-3CDS | ENST00000464104 | ENST00000375241 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| intron-3CDS | ENST00000464104 | ENST00000375242 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| intron-3CDS | ENST00000464104 | ENST00000463569 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| intron-intron | ENST00000464104 | ENST00000481149 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000375263 | HSD17B3 | chr9 | 99060698 | - | ENST00000463569 | CDC14B | chr9 | 99327765 | - | 1801 | 249 | 23 | 1546 | 507 |
| ENST00000375262 | HSD17B3 | chr9 | 99060698 | - | ENST00000463569 | CDC14B | chr9 | 99327765 | - | 1753 | 201 | 56 | 1498 | 480 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000375263 | ENST00000463569 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - | 0.001312561 | 0.99868745 |
| ENST00000375262 | ENST00000463569 | HSD17B3 | chr9 | 99060698 | - | CDC14B | chr9 | 99327765 | - | 0.001295813 | 0.9987042 |
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Fusion Genomic Features for HSD17B3-CDC14B |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for HSD17B3-CDC14B |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:99060698/chr9:99327765) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | CDC14B |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. {ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:9367992}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000265659 | 0 | 13 | 214_374 | 53 | 472.0 | Domain | Tyrosine-protein phosphatase | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375236 | 0 | 13 | 214_374 | 53 | 486.0 | Domain | Tyrosine-protein phosphatase | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375240 | 0 | 13 | 214_374 | 53 | 460.0 | Domain | Tyrosine-protein phosphatase | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375241 | 0 | 14 | 214_374 | 53 | 499.0 | Domain | Tyrosine-protein phosphatase | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375242 | 0 | 14 | 214_374 | 16 | 462.0 | Domain | Tyrosine-protein phosphatase | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000463569 | 0 | 14 | 214_374 | 53 | 518.0 | Domain | Tyrosine-protein phosphatase | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000265659 | 0 | 13 | 199_212 | 53 | 472.0 | Region | Note=Linker | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000265659 | 0 | 13 | 213_379 | 53 | 472.0 | Region | Note=B | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375236 | 0 | 13 | 199_212 | 53 | 486.0 | Region | Note=Linker | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375236 | 0 | 13 | 213_379 | 53 | 486.0 | Region | Note=B | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375240 | 0 | 13 | 199_212 | 53 | 460.0 | Region | Note=Linker | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375240 | 0 | 13 | 213_379 | 53 | 460.0 | Region | Note=B | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375241 | 0 | 14 | 199_212 | 53 | 499.0 | Region | Note=Linker | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375241 | 0 | 14 | 213_379 | 53 | 499.0 | Region | Note=B | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375242 | 0 | 14 | 199_212 | 16 | 462.0 | Region | Note=Linker | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375242 | 0 | 14 | 213_379 | 16 | 462.0 | Region | Note=B | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375242 | 0 | 14 | 44_198 | 16 | 462.0 | Region | Note=A | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000463569 | 0 | 14 | 199_212 | 53 | 518.0 | Region | Note=Linker | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000463569 | 0 | 14 | 213_379 | 53 | 518.0 | Region | Note=B |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HSD17B3 | chr9:99060698 | chr9:99327765 | ENST00000375263 | - | 2 | 11 | 48_77 | 67 | 311.0 | Nucleotide binding | NADP |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000265659 | 0 | 13 | 1_54 | 53 | 472.0 | Motif | Nucleolar localization signal | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375236 | 0 | 13 | 1_54 | 53 | 486.0 | Motif | Nucleolar localization signal | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375240 | 0 | 13 | 1_54 | 53 | 460.0 | Motif | Nucleolar localization signal | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375241 | 0 | 14 | 1_54 | 53 | 499.0 | Motif | Nucleolar localization signal | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375242 | 0 | 14 | 1_54 | 16 | 462.0 | Motif | Nucleolar localization signal | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000463569 | 0 | 14 | 1_54 | 53 | 518.0 | Motif | Nucleolar localization signal | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000265659 | 0 | 13 | 44_198 | 53 | 472.0 | Region | Note=A | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375236 | 0 | 13 | 44_198 | 53 | 486.0 | Region | Note=A | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375240 | 0 | 13 | 44_198 | 53 | 460.0 | Region | Note=A | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000375241 | 0 | 14 | 44_198 | 53 | 499.0 | Region | Note=A | |
| Tgene | CDC14B | chr9:99060698 | chr9:99327765 | ENST00000463569 | 0 | 14 | 44_198 | 53 | 518.0 | Region | Note=A |
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Fusion Gene Sequence for HSD17B3-CDC14B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >37673_37673_1_HSD17B3-CDC14B_HSD17B3_chr9_99060698_ENST00000375262_CDC14B_chr9_99327765_ENST00000463569_length(transcript)=1753nt_BP=201nt ATGGGGGACGTCCTGGAACAGTTCTTCATCCTCACAGGGCTGCTGGTGTGCCTGGCCTGCCTGGCGAAGTGCGTGAGATTCTCCAGATGT GTTTTACTGAACTACTGGAAAGTTTTGCCAAAGTCTTTCTTGCGGTCAATGGGACAGTGGGCAGTGATCACTGGAGCAGGCGATGGAATT GGGAAAGCGTACTCGTTCGAGATCGCCTTTGTTTTGCCATTCTCTACAGCAGACCAAAGAGTGCATCAAATGTACATTATTTCAGCATAG ATAATGAACTTGAATATGAGAACTTCTACGCAGATTTTGGACCACTCAATCTGGCAATGGTTTACAGATATTGTTGCAAGATCAATAAGA AATTAAAGTCCATTACAATGTTAAGGAAGAAAATTGTTCATTTTACTGGCTCTGATCAGAGAAAACAAGCAAATGCTGCCTTCCTTGTTG GATGCTACATGGTTATATATTTGGGGAGAACCCCAGAAGAAGCATATAGAATATTAATCTTTGGAGAGACATCCTATATTCCTTTCAGAG ATGCTGCCTATGGAAGTTGCAATTTCTACATTACACTTCTTGACTGTTTTCATGCAGTAAAGAAGGCAATGCAGTATGGCTTCCTTAATT TCAACTCATTTAACCTTGATGAATATGAACACTATGAAAAAGCAGAAAATGGAGATTTAAATTGGATAATACCAGACCGATTTATTGCCT TCTGTGGACCTCATTCAAGAGCCAGACTTGAAAGTGGTTACCACCAACATTCTCCTGAGACTTATATTCAATATTTTAAGAATCACAATG TTACTACCATTATTCGTCTGAATAAAAGGATGTATGATGCCAAACGCTTTACGGATGCTGGCTTCGATCACCATGATCTTTTCTTTGCGG ATGGCAGCACCCCTACTGATGCCATTGTCAAAGAATTCCTAGATATCTGTGAAAATGCTGAGGGTGCCATTGCAGTACATTGCAAAGCTG GCCTTGGTCGCACGGGCACTCTGATAGCCTGCTACATCATGAAGCATTACAGGATGACAGCAGCCGAGACCATTGCGTGGGTCAGGATCT GCAGACCTGGCTCGGTGATTGGGCCTCAGCAGCAGTTTTTGGTGATGAAGCAAACCAACCTCTGGCTGGAAGGGGACTATTTTCGTCAGA AGTTAAAGGGGCAGGAGAATGGACAACACAGAGCAGCCTTCTCCAAACTTCTCTCTGGCGTTGATGACATTTCCATAAATGGGGTCGAGA ATCAAGATCAGCAAGAACCCGAACCGTACAGTGATGATGACGAAATCAATGGAGTGACACAAGGTGATAGACTTCGGGCCTTGAAAAGCA GAAGACAATCCAAAACAAACGCTATTCCTCTCACATGTCCCCTAGCTGTGCTGACCTCTGCACTGTGTAGTGTTGTCATCTGGTGGATTG TTTGTGACTACATTCTTCCCATCCTGCTATTCTGTCTCGATGGTTTCAGAACACAGTAGCCATCAGGACCCCCTGACAGATAGCTGCTTC TCTCCATTTCAAGGACTAAAACAGTCTTGCGTTAAGTAAAAACCTGTGACCAGAGCTGAAGGAAGACTCTAGGACTGAAAACTGCAACAG AAATTAGCACAATTTGAAAACAAAACAAAATTGCAAAAGCCTTAGTTGCTTTTTCCACCTAAGAAGTTGATCAATGGAGAAAATGTCCAC >37673_37673_1_HSD17B3-CDC14B_HSD17B3_chr9_99060698_ENST00000375262_CDC14B_chr9_99327765_ENST00000463569_length(amino acids)=480AA_BP=48 MPGEVREILQMCFTELLESFAKVFLAVNGTVGSDHWSRRWNWESVLVRDRLCFAILYSRPKSASNVHYFSIDNELEYENFYADFGPLNLA MVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEEAYRILIFGETSYIPFRDAAYGSCNFYITLLDCFHA VKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTD AGFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQT NLWLEGDYFRQKLKGQENGQHRAAFSKLLSGVDDISINGVENQDQQEPEPYSDDDEINGVTQGDRLRALKSRRQSKTNAIPLTCPLAVLT -------------------------------------------------------------- >37673_37673_2_HSD17B3-CDC14B_HSD17B3_chr9_99060698_ENST00000375263_CDC14B_chr9_99327765_ENST00000463569_length(transcript)=1801nt_BP=249nt TACACAGAGAGCCACGGCCAGGGCTGAAACAGTCTGTTGAGTGCAGCCATGGGGGACGTCCTGGAACAGTTCTTCATCCTCACAGGGCTG CTGGTGTGCCTGGCCTGCCTGGCGAAGTGCGTGAGATTCTCCAGATGTGTTTTACTGAACTACTGGAAAGTTTTGCCAAAGTCTTTCTTG CGGTCAATGGGACAGTGGGCAGTGATCACTGGAGCAGGCGATGGAATTGGGAAAGCGTACTCGTTCGAGATCGCCTTTGTTTTGCCATTC TCTACAGCAGACCAAAGAGTGCATCAAATGTACATTATTTCAGCATAGATAATGAACTTGAATATGAGAACTTCTACGCAGATTTTGGAC CACTCAATCTGGCAATGGTTTACAGATATTGTTGCAAGATCAATAAGAAATTAAAGTCCATTACAATGTTAAGGAAGAAAATTGTTCATT TTACTGGCTCTGATCAGAGAAAACAAGCAAATGCTGCCTTCCTTGTTGGATGCTACATGGTTATATATTTGGGGAGAACCCCAGAAGAAG CATATAGAATATTAATCTTTGGAGAGACATCCTATATTCCTTTCAGAGATGCTGCCTATGGAAGTTGCAATTTCTACATTACACTTCTTG ACTGTTTTCATGCAGTAAAGAAGGCAATGCAGTATGGCTTCCTTAATTTCAACTCATTTAACCTTGATGAATATGAACACTATGAAAAAG CAGAAAATGGAGATTTAAATTGGATAATACCAGACCGATTTATTGCCTTCTGTGGACCTCATTCAAGAGCCAGACTTGAAAGTGGTTACC ACCAACATTCTCCTGAGACTTATATTCAATATTTTAAGAATCACAATGTTACTACCATTATTCGTCTGAATAAAAGGATGTATGATGCCA AACGCTTTACGGATGCTGGCTTCGATCACCATGATCTTTTCTTTGCGGATGGCAGCACCCCTACTGATGCCATTGTCAAAGAATTCCTAG ATATCTGTGAAAATGCTGAGGGTGCCATTGCAGTACATTGCAAAGCTGGCCTTGGTCGCACGGGCACTCTGATAGCCTGCTACATCATGA AGCATTACAGGATGACAGCAGCCGAGACCATTGCGTGGGTCAGGATCTGCAGACCTGGCTCGGTGATTGGGCCTCAGCAGCAGTTTTTGG TGATGAAGCAAACCAACCTCTGGCTGGAAGGGGACTATTTTCGTCAGAAGTTAAAGGGGCAGGAGAATGGACAACACAGAGCAGCCTTCT CCAAACTTCTCTCTGGCGTTGATGACATTTCCATAAATGGGGTCGAGAATCAAGATCAGCAAGAACCCGAACCGTACAGTGATGATGACG AAATCAATGGAGTGACACAAGGTGATAGACTTCGGGCCTTGAAAAGCAGAAGACAATCCAAAACAAACGCTATTCCTCTCACATGTCCCC TAGCTGTGCTGACCTCTGCACTGTGTAGTGTTGTCATCTGGTGGATTGTTTGTGACTACATTCTTCCCATCCTGCTATTCTGTCTCGATG GTTTCAGAACACAGTAGCCATCAGGACCCCCTGACAGATAGCTGCTTCTCTCCATTTCAAGGACTAAAACAGTCTTGCGTTAAGTAAAAA CCTGTGACCAGAGCTGAAGGAAGACTCTAGGACTGAAAACTGCAACAGAAATTAGCACAATTTGAAAACAAAACAAAATTGCAAAAGCCT TAGTTGCTTTTTCCACCTAAGAAGTTGATCAATGGAGAAAATGTCCACTGGAGTTTGAATAATGAACTTTGAGTTTGGGTGCAAGCAAAT >37673_37673_2_HSD17B3-CDC14B_HSD17B3_chr9_99060698_ENST00000375263_CDC14B_chr9_99327765_ENST00000463569_length(amino acids)=507AA_BP=75 MKQSVECSHGGRPGTVLHPHRAAGVPGLPGEVREILQMCFTELLESFAKVFLAVNGTVGSDHWSRRWNWESVLVRDRLCFAILYSRPKSA SNVHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEEAYRILIFG ETSYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRARLESGYHQHSPETY IQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAA ETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDYFRQKLKGQENGQHRAAFSKLLSGVDDISINGVENQDQQEPEPYSDDDEINGVTQG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for HSD17B3-CDC14B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for HSD17B3-CDC14B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for HSD17B3-CDC14B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HSD17B3 | C0268296 | 17-Hydroxysteroid Dehydrogenase Deficiency | 7 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | HSD17B3 | C0019269 | Hermaphroditism | 1 | CTD_human |
| Hgene | HSD17B3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | HSD17B3 | C0033804 | Pseudohermaphroditism | 1 | CTD_human |
| Hgene | HSD17B3 | C0036875 | Disorders of Sex Development | 1 | CTD_human |
| Hgene | HSD17B3 | C0266362 | Ambiguous Genitalia | 1 | CTD_human |
| Hgene | HSD17B3 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| Hgene | HSD17B3 | C2930618 | Intersex Conditions | 1 | CTD_human |
| Hgene | HSD17B3 | C2930619 | Sex Differentiation Disorders | 1 | CTD_human |
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