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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HSF1-CPSF3L (FusionGDB2 ID:HG3297TG54973)

Fusion Gene Summary for HSF1-CPSF3L

check button Fusion gene summary
Fusion gene informationFusion gene name: HSF1-CPSF3L
Fusion gene ID: hg3297tg54973
HgeneTgene
Gene symbol

HSF1

CPSF3L

Gene ID

3297

54973

Gene nameheat shock transcription factor 1integrator complex subunit 11
SynonymsHSTF1CPSF3L|CPSF73L|INT11|RC-68|RC68
Cytomap('HSF1')('CPSF3L')

8q24.3

1p36.33

Type of geneprotein-codingprotein-coding
Descriptionheat shock factor protein 1integrator complex subunit 11CPSF3-like proteincleavage and polyadenylation specific factor 3-likecleavage and polyadenylation-specific factor 3-like proteinprotein related to CPSF subunits of 68 kDarelated to CPSF subunits 68 kDa
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000528842, ENST00000400780, 
ENST00000528838, 
Fusion gene scores* DoF score10 X 6 X 8=4808 X 8 X 6=384
# samples 1210
** MAII scorelog2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/384*10)=-1.94110631094643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSF1 [Title/Abstract] AND CPSF3L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHSF1(145537302)-CPSF3L(1250998), # samples:1
Anticipated loss of major functional domain due to fusion event.HSF1-CPSF3L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HSF1-CPSF3L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HSF1-CPSF3L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HSF1-CPSF3L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSF1

GO:0000122

negative regulation of transcription by RNA polymerase II

8926278|9341107

HgeneHSF1

GO:0000165

MAPK cascade

12917326

HgeneHSF1

GO:0009299

mRNA transcription

21597468

HgeneHSF1

GO:0034605

cellular response to heat

7935471|9222587|9341107|10359787|10413683|10747973|11514557|11583998|12917326|14707147|16554823|17897941|21085490|26159920

HgeneHSF1

GO:0034620

cellular response to unfolded protein

15016915

HgeneHSF1

GO:0034622

cellular protein-containing complex assembly

11583998

HgeneHSF1

GO:0045944

positive regulation of transcription by RNA polymerase II

9341107|10561509|11514557|12917326|16278218|21085490

HgeneHSF1

GO:0061408

positive regulation of transcription from RNA polymerase II promoter in response to heat stress

7760831|9499401|10747973|12659875|12665592|15016915|25963659|26754925

HgeneHSF1

GO:0071276

cellular response to cadmium ion

10359787|11514557|15016915|25963659

HgeneHSF1

GO:0071280

cellular response to copper ion

15016915

HgeneHSF1

GO:0071480

cellular response to gamma radiation

26359349

HgeneHSF1

GO:0072738

cellular response to diamide

15016915

HgeneHSF1

GO:1900034

regulation of cellular response to heat

11583998

HgeneHSF1

GO:1903936

cellular response to sodium arsenite

15016915

TgeneCPSF3L

GO:0016180

snRNA processing

16239144


check buttonFusion gene breakpoints across HSF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CPSF3L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer67NHSF1chr8

145537302

+CPSF3Lchr1

1250998

-


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Fusion Gene ORF analysis for HSF1-CPSF3L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000528842ENST00000411962HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
3UTR-3CDSENST00000528842ENST00000435064HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
3UTR-5UTRENST00000528842ENST00000419704HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
3UTR-5UTRENST00000528842ENST00000421495HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
3UTR-5UTRENST00000528842ENST00000462432HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
3UTR-5UTRENST00000528842ENST00000540437HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
3UTR-intronENST00000528842ENST00000450926HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
3UTR-intronENST00000528842ENST00000545578HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
5CDS-5UTRENST00000400780ENST00000419704HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
5CDS-5UTRENST00000400780ENST00000421495HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
5CDS-5UTRENST00000400780ENST00000462432HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
5CDS-5UTRENST00000400780ENST00000540437HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
5CDS-5UTRENST00000528838ENST00000419704HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
5CDS-5UTRENST00000528838ENST00000421495HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
5CDS-5UTRENST00000528838ENST00000462432HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
5CDS-5UTRENST00000528838ENST00000540437HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
5CDS-intronENST00000400780ENST00000450926HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
5CDS-intronENST00000400780ENST00000545578HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
5CDS-intronENST00000528838ENST00000450926HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
5CDS-intronENST00000528838ENST00000545578HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
In-frameENST00000400780ENST00000411962HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
In-frameENST00000400780ENST00000435064HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
In-frameENST00000528838ENST00000411962HSF1chr8

145537302

+CPSF3Lchr1

1250998

-
In-frameENST00000528838ENST00000435064HSF1chr8

145537302

+CPSF3Lchr1

1250998

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000528838HSF1chr8145537302+ENST00000435064CPSF3Lchr11250998-30441408432781912
ENST00000528838HSF1chr8145537302+ENST00000411962CPSF3Lchr11250998-30401408432781912
ENST00000400780HSF1chr8145537302+ENST00000435064CPSF3Lchr11250998-28521216522589845
ENST00000400780HSF1chr8145537302+ENST00000411962CPSF3Lchr11250998-28481216522589845

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000528838ENST00000435064HSF1chr8145537302+CPSF3Lchr11250998-0.0174498730.9825501
ENST00000528838ENST00000411962HSF1chr8145537302+CPSF3Lchr11250998-0.0175411010.98245883
ENST00000400780ENST00000435064HSF1chr8145537302+CPSF3Lchr11250998-0.0185938270.9814062
ENST00000400780ENST00000411962HSF1chr8145537302+CPSF3Lchr11250998-0.0187357420.98126423

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Fusion Genomic Features for HSF1-CPSF3L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for HSF1-CPSF3L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:145537302/chr1:1250998)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSF1chr8:145537302chr1:1250998ENST00000528838+1013130_203416530.0RegionHydrophobic repeat HR-A/B
HgeneHSF1chr8:145537302chr1:1250998ENST00000528838+101315_120416530.0RegionDNA-binding domain
HgeneHSF1chr8:145537302chr1:1250998ENST00000528838+1013203_224416530.0RegionD domain
HgeneHSF1chr8:145537302chr1:1250998ENST00000528838+1013221_310416530.0RegionRegulatory domain
HgeneHSF1chr8:145537302chr1:1250998ENST00000528838+1013384_409416530.0RegionHydrophobic repeat HR-C
TgeneCPSF3Lchr8:145537302chr1:1250998ENST0000041970411568_7342500.0MotifNote=HXHXDH motif
TgeneCPSF3Lchr8:145537302chr1:1250998ENST0000045092601768_730579.0MotifNote=HXHXDH motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSF1chr8:145537302chr1:1250998ENST00000528838+1013412_420416530.0Motif9aaTAD
HgeneHSF1chr8:145537302chr1:1250998ENST00000528838+1013371_529416530.0RegionTransactivation domain
TgeneCPSF3Lchr8:145537302chr1:1250998ENST0000043506431768_73143601.0MotifNote=HXHXDH motif
TgeneCPSF3Lchr8:145537302chr1:1250998ENST0000054043751968_73149607.0MotifNote=HXHXDH motif
TgeneCPSF3Lchr8:145537302chr1:1250998ENST0000054557841868_73114572.0MotifNote=HXHXDH motif


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Fusion Gene Sequence for HSF1-CPSF3L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37706_37706_1_HSF1-CPSF3L_HSF1_chr8_145537302_ENST00000400780_CPSF3L_chr1_1250998_ENST00000411962_length(transcript)=2848nt_BP=1216nt
GAGCGGGAACAGCTTCCACGTGTTCGACCAGGGCCAGTTTGCCAAGGAGGTGCTGCCCAAGTACTTCAAGCACAACAACATGGCCAGCTT
CGTGCGGCAGCTCAACATGTATGGCTTCCGGAAAGTGGTCCACATCGAGCAGGGCGGCCTGGTCAAGCCAGAGAGAGACGACACGGAGTT
CCAGCACCCATGCTTCCTGCGTGGCCAGGAGCAGCTCCTTGAGAACATCAAGAGGAAAGTGACCAGTGTGTCCACCCTGAAGAGTGAAGA
CATAAAGATCCGCCAGGACAGCGTCACCAAGCTGCTGACGGACGTGCAGCTGATGAAGGGGAAGCAGGAGTGCATGGACTCCAAGCTCCT
GGCCATGAAGCATGAGAATGAGGCTCTGTGGCGGGAGGTGGCCAGCCTTCGGCAGAAGCATGCCCAGCAACAGAAAGTCGTCAACAAGCT
CATTCAGTTCCTGATCTCACTGGTGCAGTCAAACCGGATCCTGGGGGTGAAGAGAAAGATCCCCCTGATGCTGAACGACAGTGGCTCAGC
ACATTCCATGCCCAAGTATAGCCGGCAGTTCTCCCTGGAGCACGTCCACGGCTCGGGCCCCTACTCGGCCCCCTCCCCAGCCTACAGCAG
CTCCAGCCTCTACGCCCCTGATGCTGTGGCCAGCTCTGGACCCATCATCTCCGACATCACCGAGCTGGCTCCTGCCAGCCCCATGGCCTC
CCCCGGCGGGAGCATAGACGAGAGGCCCCTATCCAGCAGCCCCCTGGTGCGTGTCAAGGAGGAGCCCCCCAGCCCGCCTCAGAGCCCCCG
GGTAGAGGAGGCGAGTCCCGGGCGCCCATCTTCCGTGGACACCCTCTTGTCCCCGACCGCCCTCATTGACTCCATCCTGCGGGAGAGTGA
ACCTGCCCCCGCCTCCGTCACAGCCCTCACGGACGCCAGGGGCCACACGGACACCGAGGGCCGGCCTCCCTCCCCCCCGCCCACCTCCAC
CCCTGAAAAGTGCCTCAGCGTAGCCTGCCTGGACAATTTGGCTCGCACTCCACAGATGTCTAGGGTCGCCCGCCTCTTCCCCTGCCCCTC
TTCCTCTCCGCATGGCCAAGTCCAGCCAGGGAATGAGCTCAGTGACCACTTGGATGCTATGGACTCCAACCTGGATAACCTGCAGACCAT
GCTGAGCAGCCACGGCTTCAGCGTGGACACCAGTGCCCTGCTGGACGTAGATGATGAGCTGGAGATCAAGGCCTACTATGCAGGCCACGT
GCTGGGGGCAGCCATGTTCCAGATTAAAGTGGGCTCAGAGTCTGTGGTCTACACGGGTGATTATAACATGACCCCAGACCGACACTTAGG
AGCTGCCTGGATTGACAAGTGCCGCCCCAACCTGCTCATCACAGAGTCCACGTACGCCACGACCATCCGTGACTCCAAGCGCTGCCGGGA
GCGAGACTTCCTGAAGAAAGTCCACGAGACCGTGGAGCGTGGTGGGAAGGTGCTGATACCTGTGTTCGCGCTGGGCCGCGCCCAGGAGCT
CTGCATCCTCCTGGAGACCTTCTGGGAGCGCATGAACCTGAAGGTGCCCATCTACTTCTCCACGGGGCTGACCGAGAAGGCCAACCACTA
CTACAAGCTGTTCATCCCCTGGACCAACCAGAAGATCCGCAAGACTTTCGTGCAGAGGAACATGTTTGAGTTCAAGCACATCAAGGCCTT
CGACCGGGCTTTTGCTGACAACCCAGGACCGATGGTTGTGTTTGCCACGCCAGGAATGCTGCACGCTGGGCAGTCCCTGCAGATCTTCCG
GAAATGGGCCGGAAACGAAAAGAACATGGTCATCATGCCCGGCTACTGCGTGCAGGGCACCGTCGGCCACAAGATCCTCAGCGGGCAGCG
GAAGCTCGAGATGGAGGGGCGGCAGGTGCTGGAGGTCAAGATGCAGGTGGAGTACATGTCATTCAGCGCACACGCGGACGCCAAGGGCAT
CATGCAGCTGGTGGGCCAGGCAGAGCCGGAGAGCGTGCTGCTGGTGCATGGCGAGGCCAAGAAGATGGAGTTCCTGAAGCAGAAGATCGA
GCAGGAGCTCCGGGTCAACTGCTACATGCCGGCCAATGGCGAGACGGTGACGCTGCCCACAAGCCCCAGCATCCCCGTAGGCATCTCGCT
GGGGCTGCTGAAGCGGGAGATGGCGCAGGGGCTGCTCCCTGAGGCCAAGAAGCCTCGGCTCCTGCACGGCACCCTGATCATGAAGGACAG
CAACTTCCGGCTGGTGTCCTCAGAGCAAGCCCTCAAAGAGCTGGGTCTGGCTGAGCACCAGCTGCGCTTCACCTGCCGCGTGCACCTGCA
TGACACACGCAAGGAGCAGGAGACGGCATTGCGCGTCTACAGCCACCTCAAGAGCGTCCTGAAGGACCACTGTGTGCAGCACCTCCCAGA
CGGCTCTGTGACTGTGGAGTCCGTCCTCCTCCAGGCCGCCGCCCCTTCTGAGGACCCAGGCACCAAGGTGCTGCTGGTCTCCTGGACCTA
CCAGGACGAGGAGCTGGGGAGCTTCCTCACATCTCTGCTGAAGAAGGGCCTCCCCCAGGCCCCCAGCTGAGGCCGGCAACTCACCCAGCC
GCCACCTCTGCCCTCTCCCAGCTGGACAGACCCTGGGCCTGCACTTCAGGACTGTGGGTGCCCTGGGTGAACAGACCCTGCAGGTCCCAT
CCCTGGGGACAGAGGCCTTGTGTCACCTGCCTGCCCAGGCAGCTGTTTGCAGCTGAAGAAACAAACTGGTCTCCAGGCTGTCTTGCCTTT

>37706_37706_1_HSF1-CPSF3L_HSF1_chr8_145537302_ENST00000400780_CPSF3L_chr1_1250998_ENST00000411962_length(amino acids)=845AA_BP=185
MPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTKLLTDVQL
MKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHG
SGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLS
PTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDNLARTPQMSRVARLFPCPSSSPHGQVQPGNELSDHL
DAMDSNLDNLQTMLSSHGFSVDTSALLDVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITEST
YATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFV
QRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVE
YMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKK
PRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSE

--------------------------------------------------------------
>37706_37706_2_HSF1-CPSF3L_HSF1_chr8_145537302_ENST00000400780_CPSF3L_chr1_1250998_ENST00000435064_length(transcript)=2852nt_BP=1216nt
GAGCGGGAACAGCTTCCACGTGTTCGACCAGGGCCAGTTTGCCAAGGAGGTGCTGCCCAAGTACTTCAAGCACAACAACATGGCCAGCTT
CGTGCGGCAGCTCAACATGTATGGCTTCCGGAAAGTGGTCCACATCGAGCAGGGCGGCCTGGTCAAGCCAGAGAGAGACGACACGGAGTT
CCAGCACCCATGCTTCCTGCGTGGCCAGGAGCAGCTCCTTGAGAACATCAAGAGGAAAGTGACCAGTGTGTCCACCCTGAAGAGTGAAGA
CATAAAGATCCGCCAGGACAGCGTCACCAAGCTGCTGACGGACGTGCAGCTGATGAAGGGGAAGCAGGAGTGCATGGACTCCAAGCTCCT
GGCCATGAAGCATGAGAATGAGGCTCTGTGGCGGGAGGTGGCCAGCCTTCGGCAGAAGCATGCCCAGCAACAGAAAGTCGTCAACAAGCT
CATTCAGTTCCTGATCTCACTGGTGCAGTCAAACCGGATCCTGGGGGTGAAGAGAAAGATCCCCCTGATGCTGAACGACAGTGGCTCAGC
ACATTCCATGCCCAAGTATAGCCGGCAGTTCTCCCTGGAGCACGTCCACGGCTCGGGCCCCTACTCGGCCCCCTCCCCAGCCTACAGCAG
CTCCAGCCTCTACGCCCCTGATGCTGTGGCCAGCTCTGGACCCATCATCTCCGACATCACCGAGCTGGCTCCTGCCAGCCCCATGGCCTC
CCCCGGCGGGAGCATAGACGAGAGGCCCCTATCCAGCAGCCCCCTGGTGCGTGTCAAGGAGGAGCCCCCCAGCCCGCCTCAGAGCCCCCG
GGTAGAGGAGGCGAGTCCCGGGCGCCCATCTTCCGTGGACACCCTCTTGTCCCCGACCGCCCTCATTGACTCCATCCTGCGGGAGAGTGA
ACCTGCCCCCGCCTCCGTCACAGCCCTCACGGACGCCAGGGGCCACACGGACACCGAGGGCCGGCCTCCCTCCCCCCCGCCCACCTCCAC
CCCTGAAAAGTGCCTCAGCGTAGCCTGCCTGGACAATTTGGCTCGCACTCCACAGATGTCTAGGGTCGCCCGCCTCTTCCCCTGCCCCTC
TTCCTCTCCGCATGGCCAAGTCCAGCCAGGGAATGAGCTCAGTGACCACTTGGATGCTATGGACTCCAACCTGGATAACCTGCAGACCAT
GCTGAGCAGCCACGGCTTCAGCGTGGACACCAGTGCCCTGCTGGACGTAGATGATGAGCTGGAGATCAAGGCCTACTATGCAGGCCACGT
GCTGGGGGCAGCCATGTTCCAGATTAAAGTGGGCTCAGAGTCTGTGGTCTACACGGGTGATTATAACATGACCCCAGACCGACACTTAGG
AGCTGCCTGGATTGACAAGTGCCGCCCCAACCTGCTCATCACAGAGTCCACGTACGCCACGACCATCCGTGACTCCAAGCGCTGCCGGGA
GCGAGACTTCCTGAAGAAAGTCCACGAGACCGTGGAGCGTGGTGGGAAGGTGCTGATACCTGTGTTCGCGCTGGGCCGCGCCCAGGAGCT
CTGCATCCTCCTGGAGACCTTCTGGGAGCGCATGAACCTGAAGGTGCCCATCTACTTCTCCACGGGGCTGACCGAGAAGGCCAACCACTA
CTACAAGCTGTTCATCCCCTGGACCAACCAGAAGATCCGCAAGACTTTCGTGCAGAGGAACATGTTTGAGTTCAAGCACATCAAGGCCTT
CGACCGGGCTTTTGCTGACAACCCAGGACCGATGGTTGTGTTTGCCACGCCAGGAATGCTGCACGCTGGGCAGTCCCTGCAGATCTTCCG
GAAATGGGCCGGAAACGAAAAGAACATGGTCATCATGCCCGGCTACTGCGTGCAGGGCACCGTCGGCCACAAGATCCTCAGCGGGCAGCG
GAAGCTCGAGATGGAGGGGCGGCAGGTGCTGGAGGTCAAGATGCAGGTGGAGTACATGTCATTCAGCGCACACGCGGACGCCAAGGGCAT
CATGCAGCTGGTGGGCCAGGCAGAGCCGGAGAGCGTGCTGCTGGTGCATGGCGAGGCCAAGAAGATGGAGTTCCTGAAGCAGAAGATCGA
GCAGGAGCTCCGGGTCAACTGCTACATGCCGGCCAATGGCGAGACGGTGACGCTGCCCACAAGCCCCAGCATCCCCGTAGGCATCTCGCT
GGGGCTGCTGAAGCGGGAGATGGCGCAGGGGCTGCTCCCTGAGGCCAAGAAGCCTCGGCTCCTGCACGGCACCCTGATCATGAAGGACAG
CAACTTCCGGCTGGTGTCCTCAGAGCAAGCCCTCAAAGAGCTGGGTCTGGCTGAGCACCAGCTGCGCTTCACCTGCCGCGTGCACCTGCA
TGACACACGCAAGGAGCAGGAGACGGCATTGCGCGTCTACAGCCACCTCAAGAGCGTCCTGAAGGACCACTGTGTGCAGCACCTCCCAGA
CGGCTCTGTGACTGTGGAGTCCGTCCTCCTCCAGGCCGCCGCCCCTTCTGAGGACCCAGGCACCAAGGTGCTGCTGGTCTCCTGGACCTA
CCAGGACGAGGAGCTGGGGAGCTTCCTCACATCTCTGCTGAAGAAGGGCCTCCCCCAGGCCCCCAGCTGAGGCCGGCAACTCACCCAGCC
GCCACCTCTGCCCTCTCCCAGCTGGACAGACCCTGGGCCTGCACTTCAGGACTGTGGGTGCCCTGGGTGAACAGACCCTGCAGGTCCCAT
CCCTGGGGACAGAGGCCTTGTGTCACCTGCCTGCCCAGGCAGCTGTTTGCAGCTGAAGAAACAAACTGGTCTCCAGGCTGTCTTGCCTTT

>37706_37706_2_HSF1-CPSF3L_HSF1_chr8_145537302_ENST00000400780_CPSF3L_chr1_1250998_ENST00000435064_length(amino acids)=845AA_BP=185
MPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTKLLTDVQL
MKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHG
SGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLS
PTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDNLARTPQMSRVARLFPCPSSSPHGQVQPGNELSDHL
DAMDSNLDNLQTMLSSHGFSVDTSALLDVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITEST
YATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFV
QRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVE
YMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKK
PRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSE

--------------------------------------------------------------
>37706_37706_3_HSF1-CPSF3L_HSF1_chr8_145537302_ENST00000528838_CPSF3L_chr1_1250998_ENST00000411962_length(transcript)=3040nt_BP=1408nt
CGCGCCCGTTGCAAGATGGCGGCGGCCATGCTGGGCCCCGGGGCTGTGTGTGCGCAGCGGGCGGCGGCGCGGCCCGGAAGGCTGGCGCGG
CGACGGCGTTAGCCCGGCCCTCGGCCCCTCTTTGCGGCCGCTCCCTCCGCCTATTCCCTCCTTGCTCGAGATGGATCTGCCCGTGGGCCC
CGGCGCGGCGGGGCCCAGCAACGTCCCGGCCTTCCTGACCAAGCTGTGGACCCTCGTGAGCGACCCGGACACCGACGCGCTCATCTGCTG
GAGCCCGAGCGGGAACAGCTTCCACGTGTTCGACCAGGGCCAGTTTGCCAAGGAGGTGCTGCCCAAGTACTTCAAGCACAACAACATGGC
CAGCTTCGTGCGGCAGCTCAACATGTATGGCTTCCGGAAAGTGGTCCACATCGAGCAGGGCGGCCTGGTCAAGCCAGAGAGAGACGACAC
GGAGTTCCAGCACCCATGCTTCCTGCGTGGCCAGGAGCAGCTCCTTGAGAACATCAAGAGGAAAGTGACCAGTGTGTCCACCCTGAAGAG
TGAAGACATAAAGATCCGCCAGGACAGCGTCACCAAGCTGCTGACGGACGTGCAGCTGATGAAGGGGAAGCAGGAGTGCATGGACTCCAA
GCTCCTGGCCATGAAGCATGAGAATGAGGCTCTGTGGCGGGAGGTGGCCAGCCTTCGGCAGAAGCATGCCCAGCAACAGAAAGTCGTCAA
CAAGCTCATTCAGTTCCTGATCTCACTGGTGCAGTCAAACCGGATCCTGGGGGTGAAGAGAAAGATCCCCCTGATGCTGAACGACAGTGG
CTCAGCACATTCCATGCCCAAGTATAGCCGGCAGTTCTCCCTGGAGCACGTCCACGGCTCGGGCCCCTACTCGGCCCCCTCCCCAGCCTA
CAGCAGCTCCAGCCTCTACGCCCCTGATGCTGTGGCCAGCTCTGGACCCATCATCTCCGACATCACCGAGCTGGCTCCTGCCAGCCCCAT
GGCCTCCCCCGGCGGGAGCATAGACGAGAGGCCCCTATCCAGCAGCCCCCTGGTGCGTGTCAAGGAGGAGCCCCCCAGCCCGCCTCAGAG
CCCCCGGGTAGAGGAGGCGAGTCCCGGGCGCCCATCTTCCGTGGACACCCTCTTGTCCCCGACCGCCCTCATTGACTCCATCCTGCGGGA
GAGTGAACCTGCCCCCGCCTCCGTCACAGCCCTCACGGACGCCAGGGGCCACACGGACACCGAGGGCCGGCCTCCCTCCCCCCCGCCCAC
CTCCACCCCTGAAAAGTGCCTCAGCGTAGCCTGCCTGGACAAGAATGAGCTCAGTGACCACTTGGATGCTATGGACTCCAACCTGGATAA
CCTGCAGACCATGCTGAGCAGCCACGGCTTCAGCGTGGACACCAGTGCCCTGCTGGACGTAGATGATGAGCTGGAGATCAAGGCCTACTA
TGCAGGCCACGTGCTGGGGGCAGCCATGTTCCAGATTAAAGTGGGCTCAGAGTCTGTGGTCTACACGGGTGATTATAACATGACCCCAGA
CCGACACTTAGGAGCTGCCTGGATTGACAAGTGCCGCCCCAACCTGCTCATCACAGAGTCCACGTACGCCACGACCATCCGTGACTCCAA
GCGCTGCCGGGAGCGAGACTTCCTGAAGAAAGTCCACGAGACCGTGGAGCGTGGTGGGAAGGTGCTGATACCTGTGTTCGCGCTGGGCCG
CGCCCAGGAGCTCTGCATCCTCCTGGAGACCTTCTGGGAGCGCATGAACCTGAAGGTGCCCATCTACTTCTCCACGGGGCTGACCGAGAA
GGCCAACCACTACTACAAGCTGTTCATCCCCTGGACCAACCAGAAGATCCGCAAGACTTTCGTGCAGAGGAACATGTTTGAGTTCAAGCA
CATCAAGGCCTTCGACCGGGCTTTTGCTGACAACCCAGGACCGATGGTTGTGTTTGCCACGCCAGGAATGCTGCACGCTGGGCAGTCCCT
GCAGATCTTCCGGAAATGGGCCGGAAACGAAAAGAACATGGTCATCATGCCCGGCTACTGCGTGCAGGGCACCGTCGGCCACAAGATCCT
CAGCGGGCAGCGGAAGCTCGAGATGGAGGGGCGGCAGGTGCTGGAGGTCAAGATGCAGGTGGAGTACATGTCATTCAGCGCACACGCGGA
CGCCAAGGGCATCATGCAGCTGGTGGGCCAGGCAGAGCCGGAGAGCGTGCTGCTGGTGCATGGCGAGGCCAAGAAGATGGAGTTCCTGAA
GCAGAAGATCGAGCAGGAGCTCCGGGTCAACTGCTACATGCCGGCCAATGGCGAGACGGTGACGCTGCCCACAAGCCCCAGCATCCCCGT
AGGCATCTCGCTGGGGCTGCTGAAGCGGGAGATGGCGCAGGGGCTGCTCCCTGAGGCCAAGAAGCCTCGGCTCCTGCACGGCACCCTGAT
CATGAAGGACAGCAACTTCCGGCTGGTGTCCTCAGAGCAAGCCCTCAAAGAGCTGGGTCTGGCTGAGCACCAGCTGCGCTTCACCTGCCG
CGTGCACCTGCATGACACACGCAAGGAGCAGGAGACGGCATTGCGCGTCTACAGCCACCTCAAGAGCGTCCTGAAGGACCACTGTGTGCA
GCACCTCCCAGACGGCTCTGTGACTGTGGAGTCCGTCCTCCTCCAGGCCGCCGCCCCTTCTGAGGACCCAGGCACCAAGGTGCTGCTGGT
CTCCTGGACCTACCAGGACGAGGAGCTGGGGAGCTTCCTCACATCTCTGCTGAAGAAGGGCCTCCCCCAGGCCCCCAGCTGAGGCCGGCA
ACTCACCCAGCCGCCACCTCTGCCCTCTCCCAGCTGGACAGACCCTGGGCCTGCACTTCAGGACTGTGGGTGCCCTGGGTGAACAGACCC
TGCAGGTCCCATCCCTGGGGACAGAGGCCTTGTGTCACCTGCCTGCCCAGGCAGCTGTTTGCAGCTGAAGAAACAAACTGGTCTCCAGGC

>37706_37706_3_HSF1-CPSF3L_HSF1_chr8_145537302_ENST00000528838_CPSF3L_chr1_1250998_ENST00000411962_length(amino acids)=912AA_BP=280
MCVRSGRRRGPEGWRGDGVSPALGPSLRPLPPPIPSLLEMDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQ
FAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTKLL
TDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSL
EHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSV
DTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDT
SALLDVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHET
VERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGP
MVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPE
SVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQA
LKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLT

--------------------------------------------------------------
>37706_37706_4_HSF1-CPSF3L_HSF1_chr8_145537302_ENST00000528838_CPSF3L_chr1_1250998_ENST00000435064_length(transcript)=3044nt_BP=1408nt
CGCGCCCGTTGCAAGATGGCGGCGGCCATGCTGGGCCCCGGGGCTGTGTGTGCGCAGCGGGCGGCGGCGCGGCCCGGAAGGCTGGCGCGG
CGACGGCGTTAGCCCGGCCCTCGGCCCCTCTTTGCGGCCGCTCCCTCCGCCTATTCCCTCCTTGCTCGAGATGGATCTGCCCGTGGGCCC
CGGCGCGGCGGGGCCCAGCAACGTCCCGGCCTTCCTGACCAAGCTGTGGACCCTCGTGAGCGACCCGGACACCGACGCGCTCATCTGCTG
GAGCCCGAGCGGGAACAGCTTCCACGTGTTCGACCAGGGCCAGTTTGCCAAGGAGGTGCTGCCCAAGTACTTCAAGCACAACAACATGGC
CAGCTTCGTGCGGCAGCTCAACATGTATGGCTTCCGGAAAGTGGTCCACATCGAGCAGGGCGGCCTGGTCAAGCCAGAGAGAGACGACAC
GGAGTTCCAGCACCCATGCTTCCTGCGTGGCCAGGAGCAGCTCCTTGAGAACATCAAGAGGAAAGTGACCAGTGTGTCCACCCTGAAGAG
TGAAGACATAAAGATCCGCCAGGACAGCGTCACCAAGCTGCTGACGGACGTGCAGCTGATGAAGGGGAAGCAGGAGTGCATGGACTCCAA
GCTCCTGGCCATGAAGCATGAGAATGAGGCTCTGTGGCGGGAGGTGGCCAGCCTTCGGCAGAAGCATGCCCAGCAACAGAAAGTCGTCAA
CAAGCTCATTCAGTTCCTGATCTCACTGGTGCAGTCAAACCGGATCCTGGGGGTGAAGAGAAAGATCCCCCTGATGCTGAACGACAGTGG
CTCAGCACATTCCATGCCCAAGTATAGCCGGCAGTTCTCCCTGGAGCACGTCCACGGCTCGGGCCCCTACTCGGCCCCCTCCCCAGCCTA
CAGCAGCTCCAGCCTCTACGCCCCTGATGCTGTGGCCAGCTCTGGACCCATCATCTCCGACATCACCGAGCTGGCTCCTGCCAGCCCCAT
GGCCTCCCCCGGCGGGAGCATAGACGAGAGGCCCCTATCCAGCAGCCCCCTGGTGCGTGTCAAGGAGGAGCCCCCCAGCCCGCCTCAGAG
CCCCCGGGTAGAGGAGGCGAGTCCCGGGCGCCCATCTTCCGTGGACACCCTCTTGTCCCCGACCGCCCTCATTGACTCCATCCTGCGGGA
GAGTGAACCTGCCCCCGCCTCCGTCACAGCCCTCACGGACGCCAGGGGCCACACGGACACCGAGGGCCGGCCTCCCTCCCCCCCGCCCAC
CTCCACCCCTGAAAAGTGCCTCAGCGTAGCCTGCCTGGACAAGAATGAGCTCAGTGACCACTTGGATGCTATGGACTCCAACCTGGATAA
CCTGCAGACCATGCTGAGCAGCCACGGCTTCAGCGTGGACACCAGTGCCCTGCTGGACGTAGATGATGAGCTGGAGATCAAGGCCTACTA
TGCAGGCCACGTGCTGGGGGCAGCCATGTTCCAGATTAAAGTGGGCTCAGAGTCTGTGGTCTACACGGGTGATTATAACATGACCCCAGA
CCGACACTTAGGAGCTGCCTGGATTGACAAGTGCCGCCCCAACCTGCTCATCACAGAGTCCACGTACGCCACGACCATCCGTGACTCCAA
GCGCTGCCGGGAGCGAGACTTCCTGAAGAAAGTCCACGAGACCGTGGAGCGTGGTGGGAAGGTGCTGATACCTGTGTTCGCGCTGGGCCG
CGCCCAGGAGCTCTGCATCCTCCTGGAGACCTTCTGGGAGCGCATGAACCTGAAGGTGCCCATCTACTTCTCCACGGGGCTGACCGAGAA
GGCCAACCACTACTACAAGCTGTTCATCCCCTGGACCAACCAGAAGATCCGCAAGACTTTCGTGCAGAGGAACATGTTTGAGTTCAAGCA
CATCAAGGCCTTCGACCGGGCTTTTGCTGACAACCCAGGACCGATGGTTGTGTTTGCCACGCCAGGAATGCTGCACGCTGGGCAGTCCCT
GCAGATCTTCCGGAAATGGGCCGGAAACGAAAAGAACATGGTCATCATGCCCGGCTACTGCGTGCAGGGCACCGTCGGCCACAAGATCCT
CAGCGGGCAGCGGAAGCTCGAGATGGAGGGGCGGCAGGTGCTGGAGGTCAAGATGCAGGTGGAGTACATGTCATTCAGCGCACACGCGGA
CGCCAAGGGCATCATGCAGCTGGTGGGCCAGGCAGAGCCGGAGAGCGTGCTGCTGGTGCATGGCGAGGCCAAGAAGATGGAGTTCCTGAA
GCAGAAGATCGAGCAGGAGCTCCGGGTCAACTGCTACATGCCGGCCAATGGCGAGACGGTGACGCTGCCCACAAGCCCCAGCATCCCCGT
AGGCATCTCGCTGGGGCTGCTGAAGCGGGAGATGGCGCAGGGGCTGCTCCCTGAGGCCAAGAAGCCTCGGCTCCTGCACGGCACCCTGAT
CATGAAGGACAGCAACTTCCGGCTGGTGTCCTCAGAGCAAGCCCTCAAAGAGCTGGGTCTGGCTGAGCACCAGCTGCGCTTCACCTGCCG
CGTGCACCTGCATGACACACGCAAGGAGCAGGAGACGGCATTGCGCGTCTACAGCCACCTCAAGAGCGTCCTGAAGGACCACTGTGTGCA
GCACCTCCCAGACGGCTCTGTGACTGTGGAGTCCGTCCTCCTCCAGGCCGCCGCCCCTTCTGAGGACCCAGGCACCAAGGTGCTGCTGGT
CTCCTGGACCTACCAGGACGAGGAGCTGGGGAGCTTCCTCACATCTCTGCTGAAGAAGGGCCTCCCCCAGGCCCCCAGCTGAGGCCGGCA
ACTCACCCAGCCGCCACCTCTGCCCTCTCCCAGCTGGACAGACCCTGGGCCTGCACTTCAGGACTGTGGGTGCCCTGGGTGAACAGACCC
TGCAGGTCCCATCCCTGGGGACAGAGGCCTTGTGTCACCTGCCTGCCCAGGCAGCTGTTTGCAGCTGAAGAAACAAACTGGTCTCCAGGC

>37706_37706_4_HSF1-CPSF3L_HSF1_chr8_145537302_ENST00000528838_CPSF3L_chr1_1250998_ENST00000435064_length(amino acids)=912AA_BP=280
MCVRSGRRRGPEGWRGDGVSPALGPSLRPLPPPIPSLLEMDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQ
FAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTKLL
TDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSL
EHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSV
DTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDT
SALLDVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHET
VERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGP
MVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPE
SVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQA
LKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HSF1-CPSF3L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HSF1-CPSF3L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HSF1-CPSF3L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHSF1C0006826Malignant Neoplasms1CTD_human
HgeneHSF1C0027651Neoplasms1CTD_human
HgeneHSF1C0086692Benign Neoplasm1CTD_human
HgeneHSF1C1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneHSF1C1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
HgeneHSF1C4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human