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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ACACB-MARCH9 (FusionGDB2 ID:HG32TG92979) |
Fusion Gene Summary for ACACB-MARCH9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACACB-MARCH9 | Fusion gene ID: hg32tg92979 | Hgene | Tgene | Gene symbol | ACACB | MARCH9 | Gene ID | 32 | 92979 |
| Gene name | acetyl-CoA carboxylase beta | membrane associated ring-CH-type finger 9 | |
| Synonyms | ACC2|ACCB|HACC275 | MARCH-IX|MARCH9|RNF179 | |
| Cytomap | ('ACACB')('MARCH9') 12q24.11 | 12q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | acetyl-CoA carboxylase 2ACC-betaacetyl-Coenzyme A carboxylase beta | E3 ubiquitin-protein ligase MARCH9RING finger protein 179RING-type E3 ubiquitin transferase MARCH9membrane associated ring finger 9membrane-associated RING finger protein 9membrane-associated RING-CH protein IXmembrane-associated ring finger (C3HC4) | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000338432, ENST00000377848, ENST00000377854, ENST00000543201, ENST00000543080, | ||
| Fusion gene scores | * DoF score | 4 X 5 X 5=100 | 5 X 5 X 4=100 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ACACB [Title/Abstract] AND MARCH9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ACACB(109675185)-MARCH9(58150712), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | ACACB-MARCH9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACACB-MARCH9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACACB-MARCH9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACACB-MARCH9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACACB | GO:0006084 | acetyl-CoA metabolic process | 20952656 |
| Hgene | ACACB | GO:0051289 | protein homotetramerization | 20952656 |
| Fusion gene breakpoints across ACACB (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MARCH9 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-3B-A9HS-01A | ACACB | chr12 | 109675185 | - | MARCH9 | chr12 | 58150712 | + |
| ChimerDB4 | SARC | TCGA-3B-A9HS-01A | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + |
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Fusion Gene ORF analysis for ACACB-MARCH9 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000338432 | ENST00000548358 | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + |
| 5CDS-intron | ENST00000377848 | ENST00000548358 | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + |
| 5CDS-intron | ENST00000377854 | ENST00000548358 | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + |
| 5CDS-intron | ENST00000543201 | ENST00000548358 | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + |
| In-frame | ENST00000338432 | ENST00000266643 | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + |
| In-frame | ENST00000377848 | ENST00000266643 | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + |
| In-frame | ENST00000377854 | ENST00000266643 | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + |
| In-frame | ENST00000543201 | ENST00000266643 | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + |
| intron-3CDS | ENST00000543080 | ENST00000266643 | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + |
| intron-intron | ENST00000543080 | ENST00000548358 | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000338432 | ACACB | chr12 | 109675185 | + | ENST00000266643 | MARCH9 | chr12 | 58150712 | + | 6975 | 4781 | 119 | 5464 | 1781 |
| ENST00000377854 | ACACB | chr12 | 109675185 | + | ENST00000266643 | MARCH9 | chr12 | 58150712 | + | 6655 | 4461 | 9 | 5144 | 1711 |
| ENST00000377848 | ACACB | chr12 | 109675185 | + | ENST00000266643 | MARCH9 | chr12 | 58150712 | + | 6865 | 4671 | 9 | 5354 | 1781 |
| ENST00000543201 | ACACB | chr12 | 109675185 | + | ENST00000266643 | MARCH9 | chr12 | 58150712 | + | 2855 | 661 | 1 | 1344 | 447 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000338432 | ENST00000266643 | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + | 0.002828842 | 0.9971712 |
| ENST00000377854 | ENST00000266643 | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + | 0.001907217 | 0.99809283 |
| ENST00000377848 | ENST00000266643 | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + | 0.002445635 | 0.99755436 |
| ENST00000543201 | ENST00000266643 | ACACB | chr12 | 109675185 | + | MARCH9 | chr12 | 58150712 | + | 0.02852264 | 0.9714774 |
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Fusion Genomic Features for ACACB-MARCH9 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ACACB-MARCH9 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:109675185/chr12:58150712) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACACB | chr12:109675185 | chr12:58150712 | ENST00000338432 | + | 34 | 53 | 259_761 | 1554 | 2459.0 | Domain | Biotin carboxylation |
| Hgene | ACACB | chr12:109675185 | chr12:58150712 | ENST00000338432 | + | 34 | 53 | 414_609 | 1554 | 2459.0 | Domain | ATP-grasp |
| Hgene | ACACB | chr12:109675185 | chr12:58150712 | ENST00000338432 | + | 34 | 53 | 888_962 | 1554 | 2459.0 | Domain | Biotinyl-binding |
| Hgene | ACACB | chr12:109675185 | chr12:58150712 | ENST00000377848 | + | 33 | 52 | 259_761 | 1554 | 2459.0 | Domain | Biotin carboxylation |
| Hgene | ACACB | chr12:109675185 | chr12:58150712 | ENST00000377848 | + | 33 | 52 | 414_609 | 1554 | 2459.0 | Domain | ATP-grasp |
| Hgene | ACACB | chr12:109675185 | chr12:58150712 | ENST00000377848 | + | 33 | 52 | 888_962 | 1554 | 2459.0 | Domain | Biotinyl-binding |
| Hgene | ACACB | chr12:109675185 | chr12:58150712 | ENST00000338432 | + | 34 | 53 | 458_463 | 1554 | 2459.0 | Nucleotide binding | ATP |
| Hgene | ACACB | chr12:109675185 | chr12:58150712 | ENST00000377848 | + | 33 | 52 | 458_463 | 1554 | 2459.0 | Nucleotide binding | ATP |
| Tgene | MARCH9 | chr12:109675185 | chr12:58150712 | ENST00000548358 | 0 | 2 | 74_89 | 0 | 234.0 | Compositional bias | Note=Pro-rich | |
| Tgene | MARCH9 | chr12:109675185 | chr12:58150712 | ENST00000266643 | 0 | 4 | 185_205 | 119 | 347.0 | Transmembrane | Helical | |
| Tgene | MARCH9 | chr12:109675185 | chr12:58150712 | ENST00000266643 | 0 | 4 | 219_239 | 119 | 347.0 | Transmembrane | Helical | |
| Tgene | MARCH9 | chr12:109675185 | chr12:58150712 | ENST00000548358 | 0 | 2 | 185_205 | 0 | 234.0 | Transmembrane | Helical | |
| Tgene | MARCH9 | chr12:109675185 | chr12:58150712 | ENST00000548358 | 0 | 2 | 219_239 | 0 | 234.0 | Transmembrane | Helical | |
| Tgene | MARCH9 | chr12:109675185 | chr12:58150712 | ENST00000548358 | 0 | 2 | 102_162 | 0 | 234.0 | Zinc finger | RING-CH-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACACB | chr12:109675185 | chr12:58150712 | ENST00000338432 | + | 34 | 53 | 1695_2025 | 1554 | 2459.0 | Domain | CoA carboxyltransferase N-terminal |
| Hgene | ACACB | chr12:109675185 | chr12:58150712 | ENST00000338432 | + | 34 | 53 | 2029_2345 | 1554 | 2459.0 | Domain | CoA carboxyltransferase C-terminal |
| Hgene | ACACB | chr12:109675185 | chr12:58150712 | ENST00000377848 | + | 33 | 52 | 1695_2025 | 1554 | 2459.0 | Domain | CoA carboxyltransferase N-terminal |
| Hgene | ACACB | chr12:109675185 | chr12:58150712 | ENST00000377848 | + | 33 | 52 | 2029_2345 | 1554 | 2459.0 | Domain | CoA carboxyltransferase C-terminal |
| Hgene | ACACB | chr12:109675185 | chr12:58150712 | ENST00000338432 | + | 34 | 53 | 1695_2345 | 1554 | 2459.0 | Region | Carboxyltransferase |
| Hgene | ACACB | chr12:109675185 | chr12:58150712 | ENST00000377848 | + | 33 | 52 | 1695_2345 | 1554 | 2459.0 | Region | Carboxyltransferase |
| Tgene | MARCH9 | chr12:109675185 | chr12:58150712 | ENST00000266643 | 0 | 4 | 74_89 | 119 | 347.0 | Compositional bias | Note=Pro-rich | |
| Tgene | MARCH9 | chr12:109675185 | chr12:58150712 | ENST00000266643 | 0 | 4 | 102_162 | 119 | 347.0 | Zinc finger | RING-CH-type |
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Fusion Gene Sequence for ACACB-MARCH9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >1185_1185_1_ACACB-MARCH9_ACACB_chr12_109675185_ENST00000338432_MARCH9_chr12_58150712_ENST00000266643_length(transcript)=6975nt_BP=4781nt CAGCTAGCAGGCTTAGATTCAGGCCCTCAGCAAACAAGGAACCTGGAAAATGTAACCCTGAATGCACGGTGGGGAGGACATGGCAAGAGA AAAGCGGCAGGAATAAAGTGATTTTCTGAATGGTCTTGCTTCTTTGTCTATCTTGTCTGATTTTCTCCTGTCTGACCTTTTCCTGGTTAA AAATCTGGGGGAAAATGACGGACTCCAAGCCGATCACCAAGAGTAAATCAGAAGCAAACCTCATCCCGAGCCAGGAGCCCTTTCCAGCCT CTGATAACTCAGGGGAGACACCGCAGAGAAATGGGGAGGGCCACACTCTGCCCAAGACACCCAGCCAGGCCGAGCCAGCCTCCCACAAAG GCCCCAAAGATGCCGGTCGGCGGAGAAACTCCCTACCACCCTCCCACCAGAAGCCCCCAAGAAACCCCCTTTCTTCCAGTGACGCAGCAC CCTCCCCAGAGCTTCAAGCCAACGGGACTGGGACACAAGGTCTGGAGGCCACAGATACCAATGGCCTGTCCTCCTCAGCCAGGCCCCAGG GCCAGCAAGCTGGCTCCCCCTCCAAAGAAGACAAGAAGCAGGCAAACATCAAGAGGCAGCTGATGACCAACTTCATCCTGGGCTCTTTTG ATGACTACTCCTCCGACGAGGACTCTGTTGCTGGCTCATCTCGTGAGTCTACCCGGAAGGGCAGCCGGGCCAGCTTGGGGGCCCTGTCCC TGGAGGCTTATCTGACCACAGGTGAAGCTGAGACCCGCGTCCCCACTATGAGGCCGAGCATGTCGGGACTCCACCTGGTGAAGAGGGGAC GGGAACACAAGAAGCTGGACCTGCACAGAGACTTTACCGTGGCTTCTCCCGCTGAGTTTGTCACACGCTTTGGGGGGGATCGGGTCATCG AGAAGGTGCTTATTGCCAACAACGGGATTGCCGCCGTGAAGTGCATGCGCTCCATCCGCAGGTGGGCCTATGAGATGTTCCGCAACGAGC GGGCCATCCGGTTTGTTGTGATGGTGACCCCCGAGGACCTTAAGGCCAACGCAGAGTACATCAAGATGGCGGATCATTACGTCCCCGTCC CAGGAGGGCCCAATAACAACAACTATGCCAACGTGGAGCTGATTGTGGACATTGCCAAGAGAATCCCCGTGCAGGCGGTGTGGGCTGGCT GGGGCCATGCTTCAGAAAACCCTAAACTTCCGGAGCTGCTGTGCAAGAATGGAGTTGCTTTCTTAGGCCCTCCCAGTGAGGCCATGTGGG CCTTAGGAGATAAGATCGCCTCCACCGTTGTCGCCCAGACGCTACAGGTCCCAACCCTGCCCTGGAGTGGAAGCGGCCTGACAGTGGAGT GGACAGAAGATGATCTGCAGCAGGGAAAAAGAATCAGTGTCCCAGAAGATGTTTATGACAAGGGTTGCGTGAAAGACGTAGATGAGGGCT TGGAGGCAGCAGAAAGAATTGGTTTTCCATTGATGATCAAAGCTTCTGAAGGTGGCGGAGGGAAGGGAATCCGGAAGGCTGAGAGTGCGG AGGACTTCCCGATCCTTTTCAGACAAGTACAGAGTGAGATCCCAGGCTCGCCCATCTTTCTCATGAAGCTGGCCCAGCACGCCCGTCACC TGGAAGTTCAGATCCTCGCTGACCAGTATGGGAATGCTGTGTCTCTGTTTGGTCGCGACTGCTCCATCCAGCGGCGGCATCAGAAGATCG TTGAGGAAGCACCGGCCACCATCGCCCCGCTGGCCATATTCGAGTTCATGGAGCAGTGTGCCATCCGCCTGGCCAAGACCGTGGGCTATG TGAGTGCAGGGACAGTGGAATACCTCTATAGTCAGGATGGCAGCTTCCACTTCTTGGAGCTGAATCCTCGCTTGCAGGTGGAACATCCCT GCACAGAAATGATTGCTGATGTTAATCTGCCGGCCGCCCAGCTACAGATCGCCATGGGCGTGCCACTGCACCGGCTGAAGGATATCCGGC TTCTGTATGGAGAGTCACCATGGGGAGTGACTCCCATTTCTTTTGAAACCCCCTCAAACCCTCCCCTCGCCCGAGGCCACGTCATTGCCG CCAGAATCACCAGCGAAAACCCAGACGAGGGTTTTAAGCCGAGCTCCGGGACTGTCCAGGAACTGAATTTCCGGAGCAGCAAGAACGTGT GGGGTTACTTCAGCGTGGCCGCTACTGGAGGCCTGCACGAGTTTGCGGATTCCCAATTTGGGCACTGCTTCTCCTGGGGAGAGAACCGGG AAGAGGCCATTTCGAACATGGTGGTGGCTTTGAAGGAACTGTCCATCCGAGGCGACTTTAGGACTACCGTGGAATACCTCATTAACCTCC TGGAGACCGAGAGCTTCCAGAACAACGACATCGACACCGGGTGGTTGGACTACCTCATTGCTGAGAAAGTGCAGGCGGAGAAACCGGATA TCATGCTTGGGGTGGTATGCGGGGCCTTGAACGTGGCCGATGCGATGTTCAGAACGTGCATGACAGATTTCTTACACTCCCTGGAAAGGG GCCAGGTCCTCCCAGCGGATTCACTACTGAACCTCGTAGATGTGGAATTAATTTACGGAGGTGTTAAGTACATTCTCAAGGTGGCCCGGC AGTCTCTGACCATGTTCGTTCTCATCATGAATGGCTGCCACATCGAGATTGATGCCCACCGGCTGAATGATGGGGGGCTCCTGCTCTCCT ACAATGGGAACAGCTACACCACCTACATGAAGGAAGAGGTTGACAGTTACCGAATTACCATCGGCAATAAGACGTGTGTGTTTGAGAAGG AGAACGATCCTACAGTCCTGAGATCCCCCTCGGCTGGGAAGCTGACACAGTACACAGTGGAGGATGGGGGCCACGTTGAGGCTGGGAGCA GCTACGCTGAGATGGAGGTGATGAAGATGATCATGACCCTGAACGTTCAGGAAAGAGGCCGGGTGAAGTACATCAAGCGTCCAGGTGCCG TGCTGGAAGCAGGCTGCGTGGTGGCCAGGCTGGAGCTCGATGACCCTTCTAAAGTCCACCCGGCTGAACCGTTCACAGGAGAACTCCCTG CCCAGCAGACACTGCCCATCCTCGGAGAGAAACTGCACCAGGTCTTCCACAGCGTCCTGGAAAACCTCACCAACGTCATGAGTGGCTTTT GTCTGCCAGAGCCCGTTTTTAGCATAAAGCTGAAGGAGTGGGTGCAGAAGCTCATGATGACCCTCCGGCACCCGTCACTGCCGCTGCTGG AGCTGCAGGAGATCATGACCAGCGTGGCAGGCCGCATCCCCGCCCCTGTGGAGAAGTCTGTCCGCAGGGTGATGGCCCAGTATGCCAGCA ACATCACCTCGGTGCTGTGCCAGTTCCCCAGCCAGCAGATAGCCACCATCCTGGACTGCCATGCAGCCACCCTGCAGCGGAAGGCTGATC GAGAGGTCTTCTTCATCAACACCCAGAGCATCGTGCAGTTGGTCCAGAGATACCGCAGCGGGATCCGCGGCTATATGAAAACAGTGGTGT TGGATCTCCTGAGAAGATACTTGCGTGTTGAGCACCATTTTCAGCAAGCCCACTACGACAAGTGTGTGATAAACCTCAGGGAGCAGTTCA AGCCAGACATGTCCCAGGTGCTGGACTGCATCTTCTCCCACGCACAGGTGGCCAAGAAGAACCAGCTGGTGATCATGTTGATCGATGAGC TGTGTGGCCCAGACCCTTCCCTGTCGGACGAGCTGATCTCCATCCTCAACGAGCTCACTCAGCTGAGCAAAAGCGAGCACTGCAAAGTGG CCCTCAGAGCCCGGCAGATCCTGATTGCCTCCCACCTCCCCTCCTACGAGCTGCGGCATAACCAGGTGGAGTCCATTTTCCTGTCTGCCA TTGACATGTACGGCCACCAGTTCTGCCCCGAGAACCTCAAGAAATTAATACTTTCGGAAACAACCATCTTCGACGTCCTGCCTACTTTCT TCTATCACGCAAACAAAGTCGTGTGCATGGCGTCCTTGGAGGTTTACGTGCGGAGGGGCTACATCGCCTATGAGTTAAACAGCCTGCAGC ACCGGCAGCTCCCGGACGGCACCTGCGTGGTAGAATTCCAGTTCATGCTGCCGTCCTCCCACCCAAACCGGATGACCGTGCCCATCAGCA TCACCAACCCTGACCTGCTGAGGCACAGCACAGAGCTCTTCATGGACAGCGGCTTCTCCCCACTGTGCCAGCGCATGGGAGCCATGGTAG CCTTCAGGAGATTCGAGGACTTCACCAGAAATTTTGATGAAGTCATCTCTTGCTTCGCCAACGTGCCCAAAGACACCCCCCTCTTCAGCG AGGCCCGCACCTCCCTATACTCCGAGGATGACTGCAAGAGCCTCAGAGAAGAGCCCATCCACATTCTGAATGTGTCCATCCAGTGTGCAG ACCACCTGGAGGATGAGGCACTGGTGCCGATTTTACGGACATTCGTACAGTCCAAGAAAAATATCCTTGTGGATTATGGACTCCGACGAA TCACATTCTTGATTGCCCAAGAGAAAGAATTTCCCAAGTTTTTCACATTCAGAGCAAGAGATGAGTTTGCAGAAGATCGCATTTACCGTC ACTTGGAACCTGCCCTGGCCTTCCAGCTGGAACTTAACCGGATGCGTAACTTCGATCTGACCGCCGTGCCCTGTGCCAACCACAAGATGC ACCTTTACCTGGGTGCTGCCAAGGTGAAGGAAGGTGTGGAAGTGACGGACCATAGGTTCTTCATCCGCGCCATCATCAGGCACTCTGACC TGATCACAAAGGGGGAGCTCTTAAGCCCCTGCCGCTGCGACGGCTCAGTGCGCTGCACGCATCAGCCCTGCCTCATCCGCTGGATCAGCG AGAGGGGCTCCTGGAGCTGTGAGCTCTGCTACTTCAAGTACCAGGTCCTGGCGATCAGCACCAAGAACCCACTGCAGTGGCAGGCCATCT CCCTGACGGTCATCGAGAAGGTCCAGATTGCTGCCATAGTTCTGGGCTCGCTCTTCCTGGTTGCCAGCATCTCCTGGCTCATCTGGTCCT CACTCAGCCCTTCAGCCAAGTGGCAACGACAGGATCTGCTCTTTCAGATCTGCTACGGCATGTATGGCTTCATGGATGTCGTCTGCATAG GCCTCATCATCCATGAAGGCTCCTCTGTCTACCGCATCTTCAAGCGCTGGCAGGCAGTGAACCAGCAGTGGAAGGTCCTAAATTATGACA AGACCAAGGACATAGGAGGAGATGCAGGGGGAGGGACGGCAGGGAAGTCAGGCCCCAGGAACTCACGGACGGGCCCCACCTCTGGGGCCA CGAGCCGCCCCCCAGCTGCCCAGCGCATGCGGACGCTCTTGCCTCAGCGCTGCGGTTATACAATCTTGCACCTCCTTGGGCAGCTGCGGC CACCAGATGCCCGTTCCAGCTCCCATTCTGGCCGAGAGGTTGTCATGAGGGTCACTACAGTCTGAACTGGACTCCAGGAGCAGGGATCTT GAGTCAATGCATCAGTCAGAGAAGAACTCTCATGGCTGCTGGAGGTACCAGCTGGACAAGGTGTTTGGGGCATGCTGCCCCCGTCACCGA GGATCTGTGTGGGTAGCCTCAAGCTGGAGACATTGTCTGGCCTCACTGCCCACTGGGTAGAGACACCTGGATGACATTTCAGTACCCGCT GGCAGCTCCTCCCACTCATCCAGAGACGGCCGGTGGGCAGGCGGGGAGAGCAGCTTTCCTTCCCTGGAGAGAACCGTCTTTACCTCAGCT CCTAGGGCCTCCAGCCCCCCAGCTCCACCACGGTGACTTGGTGAAGGGGGACCAATGCCAGAAGAAAGGGGCTGTAGACCCCTATTCCCC ACCCCATGGCCACAGGGCATCTGGCAATAAGACTAGTATACATTGACCTCCCGTTCCCTGCATGAGGGCGGGGAGTTCCCCCTGCTCCAT CCCCCATTGCATGGGGGAAGGGCATAAAGAATCATTTATATGCACGTGGAGACTCCTTTCTCATCTGGGGCTTTTCTGGAGGGTTGGGAG ATGTGGGGAGGTTTCTCTGCACAGGTTGCAAATCCCAAATGCAGCAGTGGGTTCTGAGTTGTAGGTGTGACTCCCACTTGCTGGTGAATA ATTCATGTTGGCTGCTAGGTGGCAGCACTCCGAGGTATCTAAAGGGTAGACCTGGACCTGCCACCTATGAGTTGTGTGATATAGAAAAAA ATCTCTTAGCTCTGGTTTTCCTGTCTACTTCATAGGGTTGGAATAAGGATAAATGAGGGACAGGTTGGATGCCGTTGCAGAGAAAATCAG CAATGACATAAAGAGATTTCTAGAATAGTTGATGGTCCATTTATTTCAAATAGTAGCTGGTGTAACAAATTCTAAAATGTGTTTTTCATC TGGAGTTGCACAGAATCATGGAATTTTGTGTTGAGTGACATAATAGGTATGGAAATATGAGGGGAAATAGACATTGCAAATGTGAAGCAT GGTGGTTATTTGTTAAGAATGAGAACTCCTCTGACTCTAAATATTTGGGCCTGTGGGCTGGGGAAGGCTGGAGCCATCTGCCTTGTTCTG GAGATCATCTGGGTTCTATCAGTCCTTCTCAAGTACTGTGCTCACCCAGAAAAGCAGTGTGAAGTGAATTTGGACTCATTTGGAGTGAGA TGGAGGGAATCCCCCCACTCAGTGTTATGAGTCTCCAACCCCAGTTTAAGCTATTTCCATGGCAGTTTAGGGTCACAGGTTTGATCCCGG TGTGCCCAGCCAGTGGTATTAATGGATGGCATTATGTTTGGAGGCAGCAGCATAGAGGACTGTTGTTTATAGAGAAAAGATTTGGGAAGG ACTGTTTACAATGTGGGTCAGCCTGAAGCCTGGGCACTTTCTTCTGTGACCTTGGGGTTGTGTATTATATGAATGATGCTGTTTTTAAGT >1185_1185_1_ACACB-MARCH9_ACACB_chr12_109675185_ENST00000338432_MARCH9_chr12_58150712_ENST00000266643_length(amino acids)=1781AA_BP=1554 MVLLLCLSCLIFSCLTFSWLKIWGKMTDSKPITKSKSEANLIPSQEPFPASDNSGETPQRNGEGHTLPKTPSQAEPASHKGPKDAGRRRN SLPPSHQKPPRNPLSSSDAAPSPELQANGTGTQGLEATDTNGLSSSARPQGQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSSDEDSV AGSSRESTRKGSRASLGALSLEAYLTTGEAETRVPTMRPSMSGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGDRVIEKVLIANNGI AAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKL PELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGKRISVPEDVYDKGCVKDVDEGLEAAERIGFP LMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSPIFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAP LAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYGESPWGV TPISFETPSNPPLARGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVA LKELSIRGDFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGALNVADAMFRTCMTDFLHSLERGQVLPADSLL NLVDVELIYGGVKYILKVARQSLTMFVLIMNGCHIEIDAHRLNDGGLLLSYNGNSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSP SAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVARLELDDPSKVHPAEPFTGELPAQQTLPILGE KLHQVFHSVLENLTNVMSGFCLPEPVFSIKLKEWVQKLMMTLRHPSLPLLELQEIMTSVAGRIPAPVEKSVRRVMAQYASNITSVLCQFP SQQIATILDCHAATLQRKADREVFFINTQSIVQLVQRYRSGIRGYMKTVVLDLLRRYLRVEHHFQQAHYDKCVINLREQFKPDMSQVLDC IFSHAQVAKKNQLVIMLIDELCGPDPSLSDELISILNELTQLSKSEHCKVALRARQILIASHLPSYELRHNQVESIFLSAIDMYGHQFCP ENLKKLILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCVVEFQFMLPSSHPNRMTVPISITNPDLLRHS TELFMDSGFSPLCQRMGAMVAFRRFEDFTRNFDEVISCFANVPKDTPLFSEARTSLYSEDDCKSLREEPIHILNVSIQCADHLEDEALVP ILRTFVQSKKNILVDYGLRRITFLIAQEKEFPKFFTFRARDEFAEDRIYRHLEPALAFQLELNRMRNFDLTAVPCANHKMHLYLGAAKVK EGVEVTDHRFFIRAIIRHSDLITKGELLSPCRCDGSVRCTHQPCLIRWISERGSWSCELCYFKYQVLAISTKNPLQWQAISLTVIEKVQI AAIVLGSLFLVASISWLIWSSLSPSAKWQRQDLLFQICYGMYGFMDVVCIGLIIHEGSSVYRIFKRWQAVNQQWKVLNYDKTKDIGGDAG -------------------------------------------------------------- >1185_1185_2_ACACB-MARCH9_ACACB_chr12_109675185_ENST00000377848_MARCH9_chr12_58150712_ENST00000266643_length(transcript)=6865nt_BP=4671nt ATTTTCTGAATGGTCTTGCTTCTTTGTCTATCTTGTCTGATTTTCTCCTGTCTGACCTTTTCCTGGTTAAAAATCTGGGGGAAAATGACG GACTCCAAGCCGATCACCAAGAGTAAATCAGAAGCAAACCTCATCCCGAGCCAGGAGCCCTTTCCAGCCTCTGATAACTCAGGGGAGACA CCGCAGAGAAATGGGGAGGGCCACACTCTGCCCAAGACACCCAGCCAGGCCGAGCCAGCCTCCCACAAAGGCCCCAAAGATGCCGGTCGG CGGAGAAACTCCCTACCACCCTCCCACCAGAAGCCCCCAAGAAACCCCCTTTCTTCCAGTGACGCAGCACCCTCCCCAGAGCTTCAAGCC AACGGGACTGGGACACAAGGTCTGGAGGCCACAGATACCAATGGCCTGTCCTCCTCAGCCAGGCCCCAGGGCCAGCAAGCTGGCTCCCCC TCCAAAGAAGACAAGAAGCAGGCAAACATCAAGAGGCAGCTGATGACCAACTTCATCCTGGGCTCTTTTGATGACTACTCCTCCGACGAG GACTCTGTTGCTGGCTCATCTCGTGAGTCTACCCGGAAGGGCAGCCGGGCCAGCTTGGGGGCCCTGTCCCTGGAGGCTTATCTGACCACA GGTGAAGCTGAGACCCGCGTCCCCACTATGAGGCCGAGCATGTCGGGACTCCACCTGGTGAAGAGGGGACGGGAACACAAGAAGCTGGAC CTGCACAGAGACTTTACCGTGGCTTCTCCCGCTGAGTTTGTCACACGCTTTGGGGGGGATCGGGTCATCGAGAAGGTGCTTATTGCCAAC AACGGGATTGCCGCCGTGAAGTGCATGCGCTCCATCCGCAGGTGGGCCTATGAGATGTTCCGCAACGAGCGGGCCATCCGGTTTGTTGTG ATGGTGACCCCCGAGGACCTTAAGGCCAACGCAGAGTACATCAAGATGGCGGATCATTACGTCCCCGTCCCAGGAGGGCCCAATAACAAC AACTATGCCAACGTGGAGCTGATTGTGGACATTGCCAAGAGAATCCCCGTGCAGGCGGTGTGGGCTGGCTGGGGCCATGCTTCAGAAAAC CCTAAACTTCCGGAGCTGCTGTGCAAGAATGGAGTTGCTTTCTTAGGCCCTCCCAGTGAGGCCATGTGGGCCTTAGGAGATAAGATCGCC TCCACCGTTGTCGCCCAGACGCTACAGGTCCCAACCCTGCCCTGGAGTGGAAGCGGCCTGACAGTGGAGTGGACAGAAGATGATCTGCAG CAGGGAAAAAGAATCAGTGTCCCAGAAGATGTTTATGACAAGGGTTGCGTGAAAGACGTAGATGAGGGCTTGGAGGCAGCAGAAAGAATT GGTTTTCCATTGATGATCAAAGCTTCTGAAGGTGGCGGAGGGAAGGGAATCCGGAAGGCTGAGAGTGCGGAGGACTTCCCGATCCTTTTC AGACAAGTACAGAGTGAGATCCCAGGCTCGCCCATCTTTCTCATGAAGCTGGCCCAGCACGCCCGTCACCTGGAAGTTCAGATCCTCGCT GACCAGTATGGGAATGCTGTGTCTCTGTTTGGTCGCGACTGCTCCATCCAGCGGCGGCATCAGAAGATCGTTGAGGAAGCACCGGCCACC ATCGCCCCGCTGGCCATATTCGAGTTCATGGAGCAGTGTGCCATCCGCCTGGCCAAGACCGTGGGCTATGTGAGTGCAGGGACAGTGGAA TACCTCTATAGTCAGGATGGCAGCTTCCACTTCTTGGAGCTGAATCCTCGCTTGCAGGTGGAACATCCCTGCACAGAAATGATTGCTGAT GTTAATCTGCCGGCCGCCCAGCTACAGATCGCCATGGGCGTGCCACTGCACCGGCTGAAGGATATCCGGCTTCTGTATGGAGAGTCACCA TGGGGAGTGACTCCCATTTCTTTTGAAACCCCCTCAAACCCTCCCCTCGCCCGAGGCCACGTCATTGCCGCCAGAATCACCAGCGAAAAC CCAGACGAGGGTTTTAAGCCGAGCTCCGGGACTGTCCAGGAACTGAATTTCCGGAGCAGCAAGAACGTGTGGGGTTACTTCAGCGTGGCC GCTACTGGAGGCCTGCACGAGTTTGCGGATTCCCAATTTGGGCACTGCTTCTCCTGGGGAGAGAACCGGGAAGAGGCCATTTCGAACATG GTGGTGGCTTTGAAGGAACTGTCCATCCGAGGCGACTTTAGGACTACCGTGGAATACCTCATTAACCTCCTGGAGACCGAGAGCTTCCAG AACAACGACATCGACACCGGGTGGTTGGACTACCTCATTGCTGAGAAAGTGCAGGCGGAGAAACCGGATATCATGCTTGGGGTGGTATGC GGGGCCTTGAACGTGGCCGATGCGATGTTCAGAACGTGCATGACAGATTTCTTACACTCCCTGGAAAGGGGCCAGGTCCTCCCAGCGGAT TCACTACTGAACCTCGTAGATGTGGAATTAATTTACGGAGGTGTTAAGTACATTCTCAAGGTGGCCCGGCAGTCTCTGACCATGTTCGTT CTCATCATGAATGGCTGCCACATCGAGATTGATGCCCACCGGCTGAATGATGGGGGGCTCCTGCTCTCCTACAATGGGAACAGCTACACC ACCTACATGAAGGAAGAGGTTGACAGTTACCGAATTACCATCGGCAATAAGACGTGTGTGTTTGAGAAGGAGAACGATCCTACAGTCCTG AGATCCCCCTCGGCTGGGAAGCTGACACAGTACACAGTGGAGGATGGGGGCCACGTTGAGGCTGGGAGCAGCTACGCTGAGATGGAGGTG ATGAAGATGATCATGACCCTGAACGTTCAGGAAAGAGGCCGGGTGAAGTACATCAAGCGTCCAGGTGCCGTGCTGGAAGCAGGCTGCGTG GTGGCCAGGCTGGAGCTCGATGACCCTTCTAAAGTCCACCCGGCTGAACCGTTCACAGGAGAACTCCCTGCCCAGCAGACACTGCCCATC CTCGGAGAGAAACTGCACCAGGTCTTCCACAGCGTCCTGGAAAACCTCACCAACGTCATGAGTGGCTTTTGTCTGCCAGAGCCCGTTTTT AGCATAAAGCTGAAGGAGTGGGTGCAGAAGCTCATGATGACCCTCCGGCACCCGTCACTGCCGCTGCTGGAGCTGCAGGAGATCATGACC AGCGTGGCAGGCCGCATCCCCGCCCCTGTGGAGAAGTCTGTCCGCAGGGTGATGGCCCAGTATGCCAGCAACATCACCTCGGTGCTGTGC CAGTTCCCCAGCCAGCAGATAGCCACCATCCTGGACTGCCATGCAGCCACCCTGCAGCGGAAGGCTGATCGAGAGGTCTTCTTCATCAAC ACCCAGAGCATCGTGCAGTTGGTCCAGAGATACCGCAGCGGGATCCGCGGCTATATGAAAACAGTGGTGTTGGATCTCCTGAGAAGATAC TTGCGTGTTGAGCACCATTTTCAGCAAGCCCACTACGACAAGTGTGTGATAAACCTCAGGGAGCAGTTCAAGCCAGACATGTCCCAGGTG CTGGACTGCATCTTCTCCCACGCACAGGTGGCCAAGAAGAACCAGCTGGTGATCATGTTGATCGATGAGCTGTGTGGCCCAGACCCTTCC CTGTCGGACGAGCTGATCTCCATCCTCAACGAGCTCACTCAGCTGAGCAAAAGCGAGCACTGCAAAGTGGCCCTCAGAGCCCGGCAGATC CTGATTGCCTCCCACCTCCCCTCCTACGAGCTGCGGCATAACCAGGTGGAGTCCATTTTCCTGTCTGCCATTGACATGTACGGCCACCAG TTCTGCCCCGAGAACCTCAAGAAATTAATACTTTCGGAAACAACCATCTTCGACGTCCTGCCTACTTTCTTCTATCACGCAAACAAAGTC GTGTGCATGGCGTCCTTGGAGGTTTACGTGCGGAGGGGCTACATCGCCTATGAGTTAAACAGCCTGCAGCACCGGCAGCTCCCGGACGGC ACCTGCGTGGTAGAATTCCAGTTCATGCTGCCGTCCTCCCACCCAAACCGGATGACCGTGCCCATCAGCATCACCAACCCTGACCTGCTG AGGCACAGCACAGAGCTCTTCATGGACAGCGGCTTCTCCCCACTGTGCCAGCGCATGGGAGCCATGGTAGCCTTCAGGAGATTCGAGGAC TTCACCAGAAATTTTGATGAAGTCATCTCTTGCTTCGCCAACGTGCCCAAAGACACCCCCCTCTTCAGCGAGGCCCGCACCTCCCTATAC TCCGAGGATGACTGCAAGAGCCTCAGAGAAGAGCCCATCCACATTCTGAATGTGTCCATCCAGTGTGCAGACCACCTGGAGGATGAGGCA CTGGTGCCGATTTTACGGACATTCGTACAGTCCAAGAAAAATATCCTTGTGGATTATGGACTCCGACGAATCACATTCTTGATTGCCCAA GAGAAAGAATTTCCCAAGTTTTTCACATTCAGAGCAAGAGATGAGTTTGCAGAAGATCGCATTTACCGTCACTTGGAACCTGCCCTGGCC TTCCAGCTGGAACTTAACCGGATGCGTAACTTCGATCTGACCGCCGTGCCCTGTGCCAACCACAAGATGCACCTTTACCTGGGTGCTGCC AAGGTGAAGGAAGGTGTGGAAGTGACGGACCATAGGTTCTTCATCCGCGCCATCATCAGGCACTCTGACCTGATCACAAAGGGGGAGCTC TTAAGCCCCTGCCGCTGCGACGGCTCAGTGCGCTGCACGCATCAGCCCTGCCTCATCCGCTGGATCAGCGAGAGGGGCTCCTGGAGCTGT GAGCTCTGCTACTTCAAGTACCAGGTCCTGGCGATCAGCACCAAGAACCCACTGCAGTGGCAGGCCATCTCCCTGACGGTCATCGAGAAG GTCCAGATTGCTGCCATAGTTCTGGGCTCGCTCTTCCTGGTTGCCAGCATCTCCTGGCTCATCTGGTCCTCACTCAGCCCTTCAGCCAAG TGGCAACGACAGGATCTGCTCTTTCAGATCTGCTACGGCATGTATGGCTTCATGGATGTCGTCTGCATAGGCCTCATCATCCATGAAGGC TCCTCTGTCTACCGCATCTTCAAGCGCTGGCAGGCAGTGAACCAGCAGTGGAAGGTCCTAAATTATGACAAGACCAAGGACATAGGAGGA GATGCAGGGGGAGGGACGGCAGGGAAGTCAGGCCCCAGGAACTCACGGACGGGCCCCACCTCTGGGGCCACGAGCCGCCCCCCAGCTGCC CAGCGCATGCGGACGCTCTTGCCTCAGCGCTGCGGTTATACAATCTTGCACCTCCTTGGGCAGCTGCGGCCACCAGATGCCCGTTCCAGC TCCCATTCTGGCCGAGAGGTTGTCATGAGGGTCACTACAGTCTGAACTGGACTCCAGGAGCAGGGATCTTGAGTCAATGCATCAGTCAGA GAAGAACTCTCATGGCTGCTGGAGGTACCAGCTGGACAAGGTGTTTGGGGCATGCTGCCCCCGTCACCGAGGATCTGTGTGGGTAGCCTC AAGCTGGAGACATTGTCTGGCCTCACTGCCCACTGGGTAGAGACACCTGGATGACATTTCAGTACCCGCTGGCAGCTCCTCCCACTCATC CAGAGACGGCCGGTGGGCAGGCGGGGAGAGCAGCTTTCCTTCCCTGGAGAGAACCGTCTTTACCTCAGCTCCTAGGGCCTCCAGCCCCCC AGCTCCACCACGGTGACTTGGTGAAGGGGGACCAATGCCAGAAGAAAGGGGCTGTAGACCCCTATTCCCCACCCCATGGCCACAGGGCAT CTGGCAATAAGACTAGTATACATTGACCTCCCGTTCCCTGCATGAGGGCGGGGAGTTCCCCCTGCTCCATCCCCCATTGCATGGGGGAAG GGCATAAAGAATCATTTATATGCACGTGGAGACTCCTTTCTCATCTGGGGCTTTTCTGGAGGGTTGGGAGATGTGGGGAGGTTTCTCTGC ACAGGTTGCAAATCCCAAATGCAGCAGTGGGTTCTGAGTTGTAGGTGTGACTCCCACTTGCTGGTGAATAATTCATGTTGGCTGCTAGGT GGCAGCACTCCGAGGTATCTAAAGGGTAGACCTGGACCTGCCACCTATGAGTTGTGTGATATAGAAAAAAATCTCTTAGCTCTGGTTTTC CTGTCTACTTCATAGGGTTGGAATAAGGATAAATGAGGGACAGGTTGGATGCCGTTGCAGAGAAAATCAGCAATGACATAAAGAGATTTC TAGAATAGTTGATGGTCCATTTATTTCAAATAGTAGCTGGTGTAACAAATTCTAAAATGTGTTTTTCATCTGGAGTTGCACAGAATCATG GAATTTTGTGTTGAGTGACATAATAGGTATGGAAATATGAGGGGAAATAGACATTGCAAATGTGAAGCATGGTGGTTATTTGTTAAGAAT GAGAACTCCTCTGACTCTAAATATTTGGGCCTGTGGGCTGGGGAAGGCTGGAGCCATCTGCCTTGTTCTGGAGATCATCTGGGTTCTATC AGTCCTTCTCAAGTACTGTGCTCACCCAGAAAAGCAGTGTGAAGTGAATTTGGACTCATTTGGAGTGAGATGGAGGGAATCCCCCCACTC AGTGTTATGAGTCTCCAACCCCAGTTTAAGCTATTTCCATGGCAGTTTAGGGTCACAGGTTTGATCCCGGTGTGCCCAGCCAGTGGTATT AATGGATGGCATTATGTTTGGAGGCAGCAGCATAGAGGACTGTTGTTTATAGAGAAAAGATTTGGGAAGGACTGTTTACAATGTGGGTCA GCCTGAAGCCTGGGCACTTTCTTCTGTGACCTTGGGGTTGTGTATTATATGAATGATGCTGTTTTTAAGTAAACCATTCAACAGCAATTA >1185_1185_2_ACACB-MARCH9_ACACB_chr12_109675185_ENST00000377848_MARCH9_chr12_58150712_ENST00000266643_length(amino acids)=1781AA_BP=1554 MVLLLCLSCLIFSCLTFSWLKIWGKMTDSKPITKSKSEANLIPSQEPFPASDNSGETPQRNGEGHTLPKTPSQAEPASHKGPKDAGRRRN SLPPSHQKPPRNPLSSSDAAPSPELQANGTGTQGLEATDTNGLSSSARPQGQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSSDEDSV AGSSRESTRKGSRASLGALSLEAYLTTGEAETRVPTMRPSMSGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGDRVIEKVLIANNGI AAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKL PELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGKRISVPEDVYDKGCVKDVDEGLEAAERIGFP LMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSPIFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAP LAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYGESPWGV TPISFETPSNPPLARGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVA LKELSIRGDFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGALNVADAMFRTCMTDFLHSLERGQVLPADSLL NLVDVELIYGGVKYILKVARQSLTMFVLIMNGCHIEIDAHRLNDGGLLLSYNGNSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSP SAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVARLELDDPSKVHPAEPFTGELPAQQTLPILGE KLHQVFHSVLENLTNVMSGFCLPEPVFSIKLKEWVQKLMMTLRHPSLPLLELQEIMTSVAGRIPAPVEKSVRRVMAQYASNITSVLCQFP SQQIATILDCHAATLQRKADREVFFINTQSIVQLVQRYRSGIRGYMKTVVLDLLRRYLRVEHHFQQAHYDKCVINLREQFKPDMSQVLDC IFSHAQVAKKNQLVIMLIDELCGPDPSLSDELISILNELTQLSKSEHCKVALRARQILIASHLPSYELRHNQVESIFLSAIDMYGHQFCP ENLKKLILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCVVEFQFMLPSSHPNRMTVPISITNPDLLRHS TELFMDSGFSPLCQRMGAMVAFRRFEDFTRNFDEVISCFANVPKDTPLFSEARTSLYSEDDCKSLREEPIHILNVSIQCADHLEDEALVP ILRTFVQSKKNILVDYGLRRITFLIAQEKEFPKFFTFRARDEFAEDRIYRHLEPALAFQLELNRMRNFDLTAVPCANHKMHLYLGAAKVK EGVEVTDHRFFIRAIIRHSDLITKGELLSPCRCDGSVRCTHQPCLIRWISERGSWSCELCYFKYQVLAISTKNPLQWQAISLTVIEKVQI AAIVLGSLFLVASISWLIWSSLSPSAKWQRQDLLFQICYGMYGFMDVVCIGLIIHEGSSVYRIFKRWQAVNQQWKVLNYDKTKDIGGDAG -------------------------------------------------------------- >1185_1185_3_ACACB-MARCH9_ACACB_chr12_109675185_ENST00000377854_MARCH9_chr12_58150712_ENST00000266643_length(transcript)=6655nt_BP=4461nt ATTTTCTGAATGGTCTTGCTTCTTTGTCTATCTTGTCTGATTTTCTCCTGTCTGACCTTTTCCTGGTTAAAAATCTGGGGGAAAATGACG GACTCCAAGCCGATCACCAAGAGTAAATCAGAAGCAAACCTCATCCCGAGCCAGGAGCCCTTTCCAGCCTCTGATAACTCAGGGGAGACA CCGCAGAGAAATGGGGAGGGCCACACTCTGCCCAAGACACCCAGCCAGGCCGAGCCAGCCTCCCACAAAGGCCCCAAAGATGCCGGTCGG CGGAGAAACTCCCTACCACCCTCCCACCAGAAGCCCCCAAGAAACCCCCTTTCTTCCAGTGACGCAGCACCCTCCCCAGAGCTTCAAGCC AACGGGACTGGGACACAAGGTCTGGAGGCCACAGATACCAATGGCCTGTCCTCCTCAGCCAGGCCCCAGGGCCAGCAAGCTGGCTCCCCC TCCAAAGAAGACAAGAAGCAGGCAAACATCAAGAGGCAGCTGATGACCAACTTCATCCTGGGCTCTTTTGATGACTACTCCTCCGACGAG GACTCTGTTGCTGGCTCATCTCGTGAGTCTACCCGGAAGGGCAGCCGGGCCAGCTTGGGGGCCCTGTCCCTGGAGGCTTATCTGACCACA GGTGAAGCTGAGACCCGCGTCCCCACTATGAGGCCGAGCATGTCGGGACTCCACCTGGTGAAGAGGGGACGGGAACACAAGAAGCTGGAC CTGCACAGAGACTTTACCGTGGCTTCTCCCGCTGAGTTTGTCACACGCTTTGGGGGGGATCGGGTCATCGAGAAGGTGCTTATTGCCAAC AACGGGATTGCCGCCGTGAAGTGCATGCGCTCCATCCGCAGGTGGGCCTATGAGATGTTCCGCAACGAGCGGGCCATCCGGTTTGTTGTG ATGGTGACCCCCGAGGACCTTAAGGCCAACGCAGAGTACATCAAGATGGCGGATCATTACGTCCCCGTCCCAGGAGGGCCCAATAACAAC AACTATGCCAACGTGGAGCTGATTGTGGACATTGCCAAGAGAATCCCCGTGCAGGCGGTGTGGGCTGGCTGGGGCCATGCTTCAGAAAAC CCTAAACTTCCGGAGCTGCTGTGCAAGAATGGAGTTGCTTTCTTAGGCCCTCCCAGTGAGGCCATGTGGGCCTTAGGAGATAAGATCGCC TCCACCGTTGTCGCCCAGACGCTACAGGTCCCAACCCTGCCCTGGAGTGGAAGCGGCCTGACAGTGGAGTGGACAGAAGATGATCTGCAG CAGGGAAAAAGAATCAGTGTCCCAGAAGATGTTTATGACAAGGGTTGCGTGAAAGACGTAGATGAGGGCTTGGAGGCAGCAGAAAGAATT GGTTTTCCATTGATGATCAAAGCTTCTGAAGGTGGCGGAGGGAAGGGAATCCGGAAGGCTGAGAGTGCGGAGGACTTCCCGATCCTTTTC AGACAAGTACAGAGTGAGATCCCAGGCTCGCCCATCTTTCTCATGAAGCTGGCCCAGCACGCCCGTCACCTGGAAGTTCAGATCCTCGCT GACCAGTATGGGAATGCTGTGTCTCTGTTTGGTCGCGACTGCTCCATCCAGCGGCGGCATCAGAAGATCGTTGAGGAAGCACCGGCCACC ATCGCCCCGCTGGCCATATTCGAGTTCATGGAGCAGTGTGCCATCCGCCTGGCCAAGACCGTGGGCTATGTGAGTGCAGGGACAGTGGAA TACCTCTATAGTCAGGATGGCAGCTTCCACTTCTTGGAGCTGAATCCTCGCTTGCAGGTGGAACATCCCTGCACAGAAATGATTGCTGAT GTTAATCTGCCGGCCGCCCAGCTACAGATCGCCATGGGCGTGCCACTGCACCGGCTGAAGGATATCCGGCTTCTGTATGGAGAGTCACCA TGGGGAGTGACTCCCATTTCTTTTGAAACCCCCTCAAACCCTCCCCTCGCCCGAGGCCACGTCATTGCCGCCAGAATCACCAGCGAAAAC CCAGACGAGGGTTTTAAGCCGAGCTCCGGGACTGTCCAGGAACTGAATTTCCGGAGCAGCAAGAACGTGTGGGGTTACTTCAGCGTGGCC GCTACTGGAGGCCTGCACGAGTTTGCGGATTCCCAATTTGGGCACTGCTTCTCCTGGGGAGAGAACCGGGAAGAGGCCATTTCGAACATG GTGGTGGCTTTGAAGGAACTGTCCATCCGAGGCGACTTTAGGACTACCGTGGAATACCTCATTAACCTCCTGGAGACCGAGAGCTTCCAG AACAACGACATCGACACCGGGTGGTTGGACTACCTCATTGCTGAGAAAGTGCAGGCGGAGAAACCGGATATCATGCTTGGGGTGGTATGC GGGGCCTTGAACGTGGCCGATGCGATGTTCAGAACGTGCATGACAGATTTCTTACACTCCCTGGAAAGGGGCCAGGTCCTCCCAGCGGAT TCACTACTGAACCTCGTAGATGTGGAATTAATTTACGGAGGTGTTAAGTACATTCTCAAGGTGGCCCGGCAGTCTCTGACCATGTTCGTT CTCATCATGAATGGCTGCCACATCGAGATTGATGCCCACCGGCTGAATGATGGGGGGCTCCTGCTCTCCTACAATGGGAACAGCTACACC ACCTACATGAAGGAAGAGGTTGACAGTTACCGAATTACCATCGGCAATAAGACGTGTGTGTTTGAGAAGGAGAACGATCCTACAGTCCTG AGATCCCCCTCGGCTGGGAAGCTGACACAGTACACAGTGGAGGATGGGGGCCACGTTGAGGCTGGGAGCAGCTACGCTGAGATGGAGGTG ATGAAGATGATCATGACCCTGAACGTTCAGGAAAGAGGCCGGGTGAAGTACATCAAGCGTCCAGGTGCCGTGCTGGAAGCAGGCTGCGTG GTGGCCAGGCTGGAGCTCGATGACCCTTCTAAAGTCCACCCGGCTGAACCGTTCACAGGAGAACTCCCTGCCCAGCAGACACTGCCCATC CTCGGAGAGAAACTGCACCAGGTCTTCCACAGCGTCCTGGAAAACCTCACCAACGTCATGAGTGGCTTTTGTCTGCCAGAGCCCGTTTTT AGCATAAAGCTGAAGGAGTGGGTGCAGAAGCTCATGATGACCCTCCGGCACCCGTCACTGCCGCTGCTGGAGCTGCAGGAGATCATGACC AGCGTGGCAGGCCGCATCCCCGCCCCTGTGGAGAAGTCTGTCCGCAGGGTGATGGCCCAGTATGCCAGCAACATCACCTCGGTGCTGTGC CAGTTCCCCAGCCAGCAGATAGCCACCATCCTGGACTGCCATGCAGCCACCCTGCAGCGGAAGGCTGATCGAGAGGTCTTCTTCATCAAC ACCCAGAGCATCGTGCAGTTGGTCCAGAGCAAGGATGAGCTGTGTGGCCCAGACCCTTCCCTGTCGGACGAGCTGATCTCCATCCTCAAC GAGCTCACTCAGCTGAGCAAAAGCGAGCACTGCAAAGTGGCCCTCAGAGCCCGGCAGATCCTGATTGCCTCCCACCTCCCCTCCTACGAG CTGCGGCATAACCAGGTGGAGTCCATTTTCCTGTCTGCCATTGACATGTACGGCCACCAGTTCTGCCCCGAGAACCTCAAGAAATTAATA CTTTCGGAAACAACCATCTTCGACGTCCTGCCTACTTTCTTCTATCACGCAAACAAAGTCGTGTGCATGGCGTCCTTGGAGGTTTACGTG CGGAGGGGCTACATCGCCTATGAGTTAAACAGCCTGCAGCACCGGCAGCTCCCGGACGGCACCTGCGTGGTAGAATTCCAGTTCATGCTG CCGTCCTCCCACCCAAACCGGATGACCGTGCCCATCAGCATCACCAACCCTGACCTGCTGAGGCACAGCACAGAGCTCTTCATGGACAGC GGCTTCTCCCCACTGTGCCAGCGCATGGGAGCCATGGTAGCCTTCAGGAGATTCGAGGACTTCACCAGAAATTTTGATGAAGTCATCTCT TGCTTCGCCAACGTGCCCAAAGACACCCCCCTCTTCAGCGAGGCCCGCACCTCCCTATACTCCGAGGATGACTGCAAGAGCCTCAGAGAA GAGCCCATCCACATTCTGAATGTGTCCATCCAGTGTGCAGACCACCTGGAGGATGAGGCACTGGTGCCGATTTTACGGACATTCGTACAG TCCAAGAAAAATATCCTTGTGGATTATGGACTCCGACGAATCACATTCTTGATTGCCCAAGAGAAAGAATTTCCCAAGTTTTTCACATTC AGAGCAAGAGATGAGTTTGCAGAAGATCGCATTTACCGTCACTTGGAACCTGCCCTGGCCTTCCAGCTGGAACTTAACCGGATGCGTAAC TTCGATCTGACCGCCGTGCCCTGTGCCAACCACAAGATGCACCTTTACCTGGGTGCTGCCAAGGTGAAGGAAGGTGTGGAAGTGACGGAC CATAGGTTCTTCATCCGCGCCATCATCAGGCACTCTGACCTGATCACAAAGGGGGAGCTCTTAAGCCCCTGCCGCTGCGACGGCTCAGTG CGCTGCACGCATCAGCCCTGCCTCATCCGCTGGATCAGCGAGAGGGGCTCCTGGAGCTGTGAGCTCTGCTACTTCAAGTACCAGGTCCTG GCGATCAGCACCAAGAACCCACTGCAGTGGCAGGCCATCTCCCTGACGGTCATCGAGAAGGTCCAGATTGCTGCCATAGTTCTGGGCTCG CTCTTCCTGGTTGCCAGCATCTCCTGGCTCATCTGGTCCTCACTCAGCCCTTCAGCCAAGTGGCAACGACAGGATCTGCTCTTTCAGATC TGCTACGGCATGTATGGCTTCATGGATGTCGTCTGCATAGGCCTCATCATCCATGAAGGCTCCTCTGTCTACCGCATCTTCAAGCGCTGG CAGGCAGTGAACCAGCAGTGGAAGGTCCTAAATTATGACAAGACCAAGGACATAGGAGGAGATGCAGGGGGAGGGACGGCAGGGAAGTCA GGCCCCAGGAACTCACGGACGGGCCCCACCTCTGGGGCCACGAGCCGCCCCCCAGCTGCCCAGCGCATGCGGACGCTCTTGCCTCAGCGC TGCGGTTATACAATCTTGCACCTCCTTGGGCAGCTGCGGCCACCAGATGCCCGTTCCAGCTCCCATTCTGGCCGAGAGGTTGTCATGAGG GTCACTACAGTCTGAACTGGACTCCAGGAGCAGGGATCTTGAGTCAATGCATCAGTCAGAGAAGAACTCTCATGGCTGCTGGAGGTACCA GCTGGACAAGGTGTTTGGGGCATGCTGCCCCCGTCACCGAGGATCTGTGTGGGTAGCCTCAAGCTGGAGACATTGTCTGGCCTCACTGCC CACTGGGTAGAGACACCTGGATGACATTTCAGTACCCGCTGGCAGCTCCTCCCACTCATCCAGAGACGGCCGGTGGGCAGGCGGGGAGAG CAGCTTTCCTTCCCTGGAGAGAACCGTCTTTACCTCAGCTCCTAGGGCCTCCAGCCCCCCAGCTCCACCACGGTGACTTGGTGAAGGGGG ACCAATGCCAGAAGAAAGGGGCTGTAGACCCCTATTCCCCACCCCATGGCCACAGGGCATCTGGCAATAAGACTAGTATACATTGACCTC CCGTTCCCTGCATGAGGGCGGGGAGTTCCCCCTGCTCCATCCCCCATTGCATGGGGGAAGGGCATAAAGAATCATTTATATGCACGTGGA GACTCCTTTCTCATCTGGGGCTTTTCTGGAGGGTTGGGAGATGTGGGGAGGTTTCTCTGCACAGGTTGCAAATCCCAAATGCAGCAGTGG GTTCTGAGTTGTAGGTGTGACTCCCACTTGCTGGTGAATAATTCATGTTGGCTGCTAGGTGGCAGCACTCCGAGGTATCTAAAGGGTAGA CCTGGACCTGCCACCTATGAGTTGTGTGATATAGAAAAAAATCTCTTAGCTCTGGTTTTCCTGTCTACTTCATAGGGTTGGAATAAGGAT AAATGAGGGACAGGTTGGATGCCGTTGCAGAGAAAATCAGCAATGACATAAAGAGATTTCTAGAATAGTTGATGGTCCATTTATTTCAAA TAGTAGCTGGTGTAACAAATTCTAAAATGTGTTTTTCATCTGGAGTTGCACAGAATCATGGAATTTTGTGTTGAGTGACATAATAGGTAT GGAAATATGAGGGGAAATAGACATTGCAAATGTGAAGCATGGTGGTTATTTGTTAAGAATGAGAACTCCTCTGACTCTAAATATTTGGGC CTGTGGGCTGGGGAAGGCTGGAGCCATCTGCCTTGTTCTGGAGATCATCTGGGTTCTATCAGTCCTTCTCAAGTACTGTGCTCACCCAGA AAAGCAGTGTGAAGTGAATTTGGACTCATTTGGAGTGAGATGGAGGGAATCCCCCCACTCAGTGTTATGAGTCTCCAACCCCAGTTTAAG CTATTTCCATGGCAGTTTAGGGTCACAGGTTTGATCCCGGTGTGCCCAGCCAGTGGTATTAATGGATGGCATTATGTTTGGAGGCAGCAG CATAGAGGACTGTTGTTTATAGAGAAAAGATTTGGGAAGGACTGTTTACAATGTGGGTCAGCCTGAAGCCTGGGCACTTTCTTCTGTGAC >1185_1185_3_ACACB-MARCH9_ACACB_chr12_109675185_ENST00000377854_MARCH9_chr12_58150712_ENST00000266643_length(amino acids)=1711AA_BP=1484 MVLLLCLSCLIFSCLTFSWLKIWGKMTDSKPITKSKSEANLIPSQEPFPASDNSGETPQRNGEGHTLPKTPSQAEPASHKGPKDAGRRRN SLPPSHQKPPRNPLSSSDAAPSPELQANGTGTQGLEATDTNGLSSSARPQGQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSSDEDSV AGSSRESTRKGSRASLGALSLEAYLTTGEAETRVPTMRPSMSGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGDRVIEKVLIANNGI AAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKL PELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGKRISVPEDVYDKGCVKDVDEGLEAAERIGFP LMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSPIFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAP LAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYGESPWGV TPISFETPSNPPLARGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVA LKELSIRGDFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGALNVADAMFRTCMTDFLHSLERGQVLPADSLL NLVDVELIYGGVKYILKVARQSLTMFVLIMNGCHIEIDAHRLNDGGLLLSYNGNSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSP SAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVARLELDDPSKVHPAEPFTGELPAQQTLPILGE KLHQVFHSVLENLTNVMSGFCLPEPVFSIKLKEWVQKLMMTLRHPSLPLLELQEIMTSVAGRIPAPVEKSVRRVMAQYASNITSVLCQFP SQQIATILDCHAATLQRKADREVFFINTQSIVQLVQSKDELCGPDPSLSDELISILNELTQLSKSEHCKVALRARQILIASHLPSYELRH NQVESIFLSAIDMYGHQFCPENLKKLILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCVVEFQFMLPSS HPNRMTVPISITNPDLLRHSTELFMDSGFSPLCQRMGAMVAFRRFEDFTRNFDEVISCFANVPKDTPLFSEARTSLYSEDDCKSLREEPI HILNVSIQCADHLEDEALVPILRTFVQSKKNILVDYGLRRITFLIAQEKEFPKFFTFRARDEFAEDRIYRHLEPALAFQLELNRMRNFDL TAVPCANHKMHLYLGAAKVKEGVEVTDHRFFIRAIIRHSDLITKGELLSPCRCDGSVRCTHQPCLIRWISERGSWSCELCYFKYQVLAIS TKNPLQWQAISLTVIEKVQIAAIVLGSLFLVASISWLIWSSLSPSAKWQRQDLLFQICYGMYGFMDVVCIGLIIHEGSSVYRIFKRWQAV NQQWKVLNYDKTKDIGGDAGGGTAGKSGPRNSRTGPTSGATSRPPAAQRMRTLLPQRCGYTILHLLGQLRPPDARSSSHSGREVVMRVTT -------------------------------------------------------------- >1185_1185_4_ACACB-MARCH9_ACACB_chr12_109675185_ENST00000543201_MARCH9_chr12_58150712_ENST00000266643_length(transcript)=2855nt_BP=661nt GATGACCGTGCCCATCAGCATCACCAACCCTGACCTGCTGAGGCACAGCACAGAGCTCTTCATGGACAGCGGCTTCTCCCCACTGTGCCA GCGCATGGGAGCCATGGTAGCCTTCAGGAGATTCGAGGACTTCACCAGAAATTTTGATGAAGTCATCTCTTGCTTCGCCAACGTGCCCAA AGACACCCCCCTCTTCAGCGAGGCCCGCACCTCCCTATACTCCGAGGATGACTGCAAGAGCCTCAGAGAAGAGCCCATCCACATTCTGAA TGTGTCCATCCAGTGTGCAGACCACCTGGAGGATGAGGCACTGGTGCCGATTTTACGGACATTCGTACAGTCCAAGAAAAATATCCTTGT GGATTATGGACTCCGACGAATCACATTCTTGATTGCCCAAGAGAAAGAATTTCCCAAGTTTTTCACATTCAGAGCAAGAGATGAGTTTGC AGAAGATCGCATTTACCGTCACTTGGAACCTGCCCTGGCCTTCCAGCTGGAACTTAACCGGATGCGTAACTTCGATCTGACCGCCGTGCC CTGTGCCAACCACAAGATGCACCTTTACCTGGGTGCTGCCAAGGTGAAGGAAGGTGTGGAAGTGACGGACCATAGGTTCTTCATCCGCGC CATCATCAGGCACTCTGACCTGATCACAAAGGGGGAGCTCTTAAGCCCCTGCCGCTGCGACGGCTCAGTGCGCTGCACGCATCAGCCCTG CCTCATCCGCTGGATCAGCGAGAGGGGCTCCTGGAGCTGTGAGCTCTGCTACTTCAAGTACCAGGTCCTGGCGATCAGCACCAAGAACCC ACTGCAGTGGCAGGCCATCTCCCTGACGGTCATCGAGAAGGTCCAGATTGCTGCCATAGTTCTGGGCTCGCTCTTCCTGGTTGCCAGCAT CTCCTGGCTCATCTGGTCCTCACTCAGCCCTTCAGCCAAGTGGCAACGACAGGATCTGCTCTTTCAGATCTGCTACGGCATGTATGGCTT CATGGATGTCGTCTGCATAGGCCTCATCATCCATGAAGGCTCCTCTGTCTACCGCATCTTCAAGCGCTGGCAGGCAGTGAACCAGCAGTG GAAGGTCCTAAATTATGACAAGACCAAGGACATAGGAGGAGATGCAGGGGGAGGGACGGCAGGGAAGTCAGGCCCCAGGAACTCACGGAC GGGCCCCACCTCTGGGGCCACGAGCCGCCCCCCAGCTGCCCAGCGCATGCGGACGCTCTTGCCTCAGCGCTGCGGTTATACAATCTTGCA CCTCCTTGGGCAGCTGCGGCCACCAGATGCCCGTTCCAGCTCCCATTCTGGCCGAGAGGTTGTCATGAGGGTCACTACAGTCTGAACTGG ACTCCAGGAGCAGGGATCTTGAGTCAATGCATCAGTCAGAGAAGAACTCTCATGGCTGCTGGAGGTACCAGCTGGACAAGGTGTTTGGGG CATGCTGCCCCCGTCACCGAGGATCTGTGTGGGTAGCCTCAAGCTGGAGACATTGTCTGGCCTCACTGCCCACTGGGTAGAGACACCTGG ATGACATTTCAGTACCCGCTGGCAGCTCCTCCCACTCATCCAGAGACGGCCGGTGGGCAGGCGGGGAGAGCAGCTTTCCTTCCCTGGAGA GAACCGTCTTTACCTCAGCTCCTAGGGCCTCCAGCCCCCCAGCTCCACCACGGTGACTTGGTGAAGGGGGACCAATGCCAGAAGAAAGGG GCTGTAGACCCCTATTCCCCACCCCATGGCCACAGGGCATCTGGCAATAAGACTAGTATACATTGACCTCCCGTTCCCTGCATGAGGGCG GGGAGTTCCCCCTGCTCCATCCCCCATTGCATGGGGGAAGGGCATAAAGAATCATTTATATGCACGTGGAGACTCCTTTCTCATCTGGGG CTTTTCTGGAGGGTTGGGAGATGTGGGGAGGTTTCTCTGCACAGGTTGCAAATCCCAAATGCAGCAGTGGGTTCTGAGTTGTAGGTGTGA CTCCCACTTGCTGGTGAATAATTCATGTTGGCTGCTAGGTGGCAGCACTCCGAGGTATCTAAAGGGTAGACCTGGACCTGCCACCTATGA GTTGTGTGATATAGAAAAAAATCTCTTAGCTCTGGTTTTCCTGTCTACTTCATAGGGTTGGAATAAGGATAAATGAGGGACAGGTTGGAT GCCGTTGCAGAGAAAATCAGCAATGACATAAAGAGATTTCTAGAATAGTTGATGGTCCATTTATTTCAAATAGTAGCTGGTGTAACAAAT TCTAAAATGTGTTTTTCATCTGGAGTTGCACAGAATCATGGAATTTTGTGTTGAGTGACATAATAGGTATGGAAATATGAGGGGAAATAG ACATTGCAAATGTGAAGCATGGTGGTTATTTGTTAAGAATGAGAACTCCTCTGACTCTAAATATTTGGGCCTGTGGGCTGGGGAAGGCTG GAGCCATCTGCCTTGTTCTGGAGATCATCTGGGTTCTATCAGTCCTTCTCAAGTACTGTGCTCACCCAGAAAAGCAGTGTGAAGTGAATT TGGACTCATTTGGAGTGAGATGGAGGGAATCCCCCCACTCAGTGTTATGAGTCTCCAACCCCAGTTTAAGCTATTTCCATGGCAGTTTAG GGTCACAGGTTTGATCCCGGTGTGCCCAGCCAGTGGTATTAATGGATGGCATTATGTTTGGAGGCAGCAGCATAGAGGACTGTTGTTTAT AGAGAAAAGATTTGGGAAGGACTGTTTACAATGTGGGTCAGCCTGAAGCCTGGGCACTTTCTTCTGTGACCTTGGGGTTGTGTATTATAT >1185_1185_4_ACACB-MARCH9_ACACB_chr12_109675185_ENST00000543201_MARCH9_chr12_58150712_ENST00000266643_length(amino acids)=447AA_BP=220 MTVPISITNPDLLRHSTELFMDSGFSPLCQRMGAMVAFRRFEDFTRNFDEVISCFANVPKDTPLFSEARTSLYSEDDCKSLREEPIHILN VSIQCADHLEDEALVPILRTFVQSKKNILVDYGLRRITFLIAQEKEFPKFFTFRARDEFAEDRIYRHLEPALAFQLELNRMRNFDLTAVP CANHKMHLYLGAAKVKEGVEVTDHRFFIRAIIRHSDLITKGELLSPCRCDGSVRCTHQPCLIRWISERGSWSCELCYFKYQVLAISTKNP LQWQAISLTVIEKVQIAAIVLGSLFLVASISWLIWSSLSPSAKWQRQDLLFQICYGMYGFMDVVCIGLIIHEGSSVYRIFKRWQAVNQQW -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ACACB-MARCH9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACACB-MARCH9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ACACB-MARCH9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ACACB | C0021655 | Insulin Resistance | 1 | CTD_human |
| Hgene | ACACB | C0028754 | Obesity | 1 | CTD_human |
| Hgene | ACACB | C0920563 | Insulin Sensitivity | 1 | CTD_human |
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