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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:APOA2-FOXO1 (FusionGDB2 ID:HG336TG2308) |
Fusion Gene Summary for APOA2-FOXO1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: APOA2-FOXO1 | Fusion gene ID: hg336tg2308 | Hgene | Tgene | Gene symbol | APOA2 | FOXO1 | Gene ID | 336 | 2308 |
| Gene name | apolipoprotein A2 | forkhead box O1 | |
| Synonyms | Apo-AII|ApoA-II|apoAII | FKH1|FKHR|FOXO1A | |
| Cytomap | ('APOA2')('FOXO1') 1q23.3 | 13q14.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | apolipoprotein A-II | forkhead box protein O1forkhead box protein O1Aforkhead, Drosophila, homolog of, in rhabdomyosarcoma | |
| Modification date | 20200327 | 20200322 | |
| UniProtAcc | P02652 | Q12778 | |
| Ensembl transtripts involved in fusion gene | ENST00000367990, ENST00000463812, ENST00000468465, ENST00000470459, ENST00000464492, ENST00000491350, | ||
| Fusion gene scores | * DoF score | 28 X 4 X 2=224 | 11 X 11 X 7=847 |
| # samples | 29 | 14 | |
| ** MAII score | log2(29/224*10)=0.37255416795733 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(14/847*10)=-2.59693514238723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: APOA2 [Title/Abstract] AND FOXO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | APOA2(161192082)-FOXO1(41177483), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | APOA2 | GO:0002740 | negative regulation of cytokine secretion involved in immune response | 12458630 |
| Hgene | APOA2 | GO:0006656 | phosphatidylcholine biosynthetic process | 14967812 |
| Hgene | APOA2 | GO:0009395 | phospholipid catabolic process | 14967812 |
| Hgene | APOA2 | GO:0009749 | response to glucose | 14988251 |
| Hgene | APOA2 | GO:0010873 | positive regulation of cholesterol esterification | 14967812 |
| Hgene | APOA2 | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling | 14967812 |
| Hgene | APOA2 | GO:0018158 | protein oxidation | 12576517 |
| Hgene | APOA2 | GO:0018206 | peptidyl-methionine modification | 12576517 |
| Hgene | APOA2 | GO:0031647 | regulation of protein stability | 14967812 |
| Hgene | APOA2 | GO:0033344 | cholesterol efflux | 11162594 |
| Hgene | APOA2 | GO:0033700 | phospholipid efflux | 11162594 |
| Hgene | APOA2 | GO:0034370 | triglyceride-rich lipoprotein particle remodeling | 14967812 |
| Hgene | APOA2 | GO:0034374 | low-density lipoprotein particle remodeling | 8106353 |
| Hgene | APOA2 | GO:0034375 | high-density lipoprotein particle remodeling | 8106353|14967812 |
| Hgene | APOA2 | GO:0034380 | high-density lipoprotein particle assembly | 218942 |
| Hgene | APOA2 | GO:0034384 | high-density lipoprotein particle clearance | 10764676 |
| Hgene | APOA2 | GO:0042632 | cholesterol homeostasis | 14967812 |
| Hgene | APOA2 | GO:0043691 | reverse cholesterol transport | 14967812 |
| Hgene | APOA2 | GO:0045416 | positive regulation of interleukin-8 biosynthetic process | 11591715 |
| Hgene | APOA2 | GO:0046340 | diacylglycerol catabolic process | 14967812 |
| Hgene | APOA2 | GO:0050766 | positive regulation of phagocytosis | 20495215 |
| Hgene | APOA2 | GO:0050821 | protein stabilization | 20495215 |
| Hgene | APOA2 | GO:0050995 | negative regulation of lipid catabolic process | 14967812 |
| Hgene | APOA2 | GO:0050996 | positive regulation of lipid catabolic process | 8640403 |
| Hgene | APOA2 | GO:0060192 | negative regulation of lipase activity | 14967812 |
| Hgene | APOA2 | GO:0060621 | negative regulation of cholesterol import | 10764676 |
| Hgene | APOA2 | GO:0060695 | negative regulation of cholesterol transporter activity | 8106353 |
| Tgene | FOXO1 | GO:0009267 | cellular response to starvation | 20543840 |
| Tgene | FOXO1 | GO:0032873 | negative regulation of stress-activated MAPK cascade | 19696738 |
| Tgene | FOXO1 | GO:0043066 | negative regulation of apoptotic process | 10871843 |
| Tgene | FOXO1 | GO:0045893 | positive regulation of transcription, DNA-templated | 7862145|10871843|12228231 |
| Tgene | FOXO1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10871843|12228231 |
| Tgene | FOXO1 | GO:0071455 | cellular response to hyperoxia | 20543840 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for APOA2-FOXO1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for APOA2-FOXO1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for APOA2-FOXO1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:161192082/:41177483) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| APOA2 | FOXO1 |
| FUNCTION: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. | FUNCTION: Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for APOA2-FOXO1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for APOA2-FOXO1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for APOA2-FOXO1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | APOA2 | P02652 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
| Hgene | APOA2 | P02652 | DB09130 | Copper | Small molecule | Approved|Investigational | |
| Hgene | APOA2 | P02652 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational |
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Related Diseases for APOA2-FOXO1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | APOA2 | C0020445 | Hypercholesterolemia, Familial | 1 | CTD_human |
| Hgene | APOA2 | C0745103 | Hyperlipoproteinemia Type IIa | 1 | CTD_human;GENOMICS_ENGLAND |
| Hgene | APOA2 | C1704417 | Hyperlipoproteinemia Type IIb | 1 | CTD_human |
| Tgene | C0020542 | Pulmonary Hypertension | 1 | CTD_human | |
| Tgene | C0022578 | Keratoconus | 1 | CTD_human | |
| Tgene | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human | |
| Tgene | C0026998 | Acute Myeloid Leukemia, M1 | 1 | CTD_human | |
| Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
| Tgene | C0206655 | Alveolar rhabdomyosarcoma | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET | |
| Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human | |
| Tgene | C1879321 | Acute Myeloid Leukemia (AML-M2) | 1 | CTD_human |
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