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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHSY3-DDX46 (FusionGDB2 ID:HG337876TG9879)

Fusion Gene Summary for CHSY3-DDX46

check button Fusion gene summary
Fusion gene informationFusion gene name: CHSY3-DDX46
Fusion gene ID: hg337876tg9879
HgeneTgene
Gene symbol

CHSY3

DDX46

Gene ID

337876

9879

Gene namechondroitin sulfate synthase 3DEAD-box helicase 46
SynonymsCHSY2|CSS3PRPF5|Prp5
Cytomap('CHSY3')('DDX46')

5q23.3

5q31.1

Type of geneprotein-codingprotein-coding
Descriptionchondroitin sulfate synthase 3N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3N-acetylgalactosaminyltransferase 3carbohydrate synthase 2chSy-2chondroitin glucuronyltransferase 3chondroitin synthase-2glucuronosyl-N-acetylgalactosprobable ATP-dependent RNA helicase DDX46DEAD (Asp-Glu-Ala-Asp) box polypeptide 46DEAD box protein 46PRP5 homologPrp5-like DEAD-box proteinRNA helicase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000507545, ENST00000305031, 
Fusion gene scores* DoF score9 X 6 X 5=27011 X 9 X 6=594
# samples 1012
** MAII scorelog2(10/270*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/594*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHSY3 [Title/Abstract] AND DDX46 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHSY3(129244053)-DDX46(134130540), # samples:1
Anticipated loss of major functional domain due to fusion event.CHSY3-DDX46 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHSY3-DDX46 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHSY3-DDX46 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CHSY3-DDX46 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CHSY3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DDX46 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-P5-A72W-01ACHSY3chr5

129244053

-DDX46chr5

134130540

+


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Fusion Gene ORF analysis for CHSY3-DDX46

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000507545ENST00000354283CHSY3chr5

129244053

-DDX46chr5

134130540

+
3UTR-3CDSENST00000507545ENST00000452510CHSY3chr5

129244053

-DDX46chr5

134130540

+
3UTR-3UTRENST00000507545ENST00000509178CHSY3chr5

129244053

-DDX46chr5

134130540

+
5CDS-3UTRENST00000305031ENST00000509178CHSY3chr5

129244053

-DDX46chr5

134130540

+
In-frameENST00000305031ENST00000354283CHSY3chr5

129244053

-DDX46chr5

134130540

+
In-frameENST00000305031ENST00000452510CHSY3chr5

129244053

-DDX46chr5

134130540

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000305031CHSY3chr5129244053-ENST00000452510DDX46chr5134130540+534914443582916852
ENST00000305031CHSY3chr5129244053-ENST00000354283DDX46chr5134130540+350414443582913851

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000305031ENST00000452510CHSY3chr5129244053-DDX46chr5134130540+0.000169910.99983
ENST00000305031ENST00000354283CHSY3chr5129244053-DDX46chr5134130540+0.0011801490.99881977

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Fusion Genomic Features for CHSY3-DDX46


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CHSY3-DDX46


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:129244053/chr5:134130540)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHSY3chr5:129244053chr5:134130540ENST00000305031-23211_235362883.0Compositional biasNote=Pro-rich
HgeneCHSY3chr5:129244053chr5:134130540ENST00000305031-231_7362883.0Topological domainCytoplasmic
HgeneCHSY3chr5:129244053chr5:134130540ENST00000305031-238_28362883.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneDDX46chr5:129244053chr5:134130540ENST000003542831223592_7535421032.0DomainHelicase C-terminal
TgeneDDX46chr5:129244053chr5:134130540ENST000004525101223592_7535421033.0DomainHelicase C-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHSY3chr5:129244053chr5:134130540ENST00000305031-23539_544362883.0Compositional biasNote=Poly-Leu
HgeneCHSY3chr5:129244053chr5:134130540ENST00000305031-2329_882362883.0Topological domainLumenal
TgeneDDX46chr5:129244053chr5:134130540ENST000003542831223152_1975421032.0Coiled coilOntology_term=ECO:0000255
TgeneDDX46chr5:129244053chr5:134130540ENST000004525101223152_1975421033.0Coiled coilOntology_term=ECO:0000255
TgeneDDX46chr5:129244053chr5:134130540ENST000003542831223202_2095421032.0Compositional biasNote=Poly-Asp
TgeneDDX46chr5:129244053chr5:134130540ENST0000035428312233_1035421032.0Compositional biasNote=Arg-rich
TgeneDDX46chr5:129244053chr5:134130540ENST000004525101223202_2095421033.0Compositional biasNote=Poly-Asp
TgeneDDX46chr5:129244053chr5:134130540ENST0000045251012233_1035421033.0Compositional biasNote=Arg-rich
TgeneDDX46chr5:129244053chr5:134130540ENST000003542831223403_5815421032.0DomainHelicase ATP-binding
TgeneDDX46chr5:129244053chr5:134130540ENST000004525101223403_5815421033.0DomainHelicase ATP-binding
TgeneDDX46chr5:129244053chr5:134130540ENST000003542831223372_4005421032.0MotifNote=Q motif
TgeneDDX46chr5:129244053chr5:134130540ENST000003542831223529_5325421032.0MotifNote=DEAD box
TgeneDDX46chr5:129244053chr5:134130540ENST000004525101223372_4005421033.0MotifNote=Q motif
TgeneDDX46chr5:129244053chr5:134130540ENST000004525101223529_5325421033.0MotifNote=DEAD box
TgeneDDX46chr5:129244053chr5:134130540ENST000003542831223416_4235421032.0Nucleotide bindingATP
TgeneDDX46chr5:129244053chr5:134130540ENST000004525101223416_4235421033.0Nucleotide bindingATP


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Fusion Gene Sequence for CHSY3-DDX46


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16735_16735_1_CHSY3-DDX46_CHSY3_chr5_129244053_ENST00000305031_DDX46_chr5_134130540_ENST00000354283_length(transcript)=3504nt_BP=1444nt
GGGTGGCAGCCTAGGAGCGGACGCGTTGCCGCCGCCGCTGCTCCTCCTCCTCCTCCTGCAGCTCCTCCAGCTGCCGCTGCTGCCGCCGCT
GCCGCCACCGCCGCCGCCGGGAGAAGTTTCACTCCCGACCCTTGCTCGGAGCCCCGGCCCAGAGCTGAGCGGGAGCCCGGCAGGCAGCTG
CAGCCCGCGGCAGTCGAGGCGTCCGCGGCGCTTCGACCTCCAGCCGGTGTCGGCGCCTAGGCGGCCGGCTGCGGCCGCGGCTGGGGGCGC
AAAGGCGGAGGAGGGGCGGGTGTGAGCCGGGGAAACCGCGTGCCGCGCCGCGACAGCCCAGCGAGCGTCCGCGCCCGGGACAGCCGCGAT
GGCTGTGCGCTCTCGCCGCCCGTGGATGAGCGTGGCATTAGGGCTGGTGCTGGGCTTCACCGCCGCGTCCTGGCTCATCGCCCCCAGGGT
GGCGGAGCTGAGCGAGAGGAAGAGACGTGGCTCCAGCCTCTGCTCCTACTACGGTCGCTCTGCTGCTGGCCCCCGCGCCGGCGCTCAGCA
GCCGCTCCCCCAGCCCCAGTCCCGACCACGGCAGGAGCAGTCGCCGCCCCCCGCGCGCCAGGATCTCCAGGGGCCACCGCTGCCCGAGGC
AGCACCCGGGATCACCAGTTTTCGAAGCAGCCCCTGGCAGCAGCCACCTCCGCTGCAGCAGCGGCGGCGAGGACGCGAGCCTGAGGGCGC
GACGGGGCTTCCCGGTGCTCCAGCGGCCGAGGGGGAGCCCGAGGAGGAGGACGGGGGCGCGGCTGGGCAGCGGAGAGACGGCCGGCCGGG
GAGTAGCCACAACGGCAGCGGGGACGGGGGCGCTGCCGCCCCGAGCGCCCGACCCCGGGACTTCCTGTACGTGGGGGTGATGACCGCGCA
GAAGTACCTGGGCAGCCGCGCGCTGGCCGCGCAGCGGACCTGGGCGCGTTTCATCCCGGGCCGCGTGGAGTTCTTTTCCAGCCAGCAGCC
CCCCAACGCCGGCCAGCCCCCGCCACCCCTGCCTGTCATCGCGCTACCGGGTGTGGACGACTCCTATCCTCCCCAGAAAAAGTCCTTCAT
GATGATCAAGTACATGCACGACCACTACCTGGACAAGTATGAGTGGTTCATGCGCGCCGACGACGATGTCTACATCAAAGGTGATAAATT
AGAAGAGTTTCTTAGATCGCTAAACAGCAGTAAGCCTCTCTACCTGGGACAGACTGGCCTGGGGAATATTGAAGAGCTTGGAAAGCTGGG
ACTGGAGCCTGGGGAAAACTTCTGTATGGGAGGACCTGGCATGATCTTTAGCCGAGAAGTTCTCAGGAGGATGGTGCCACATATTGGTGA
ATGCCTTAGAGAAATGTACACGACTCATGAGGATGTGGAAGTAGGAAGATGCGTTCGCCGTTTTGGTGGGACTCAGTGTGTCTGGTCTTA
CGAGGTCATGCGCATCGTGGATAATGTTCGTCCTGATCGACAGACGGTTATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTTTGGC
TCGCAGGATCCTCAGTAAACCTATTGAAGTACAAGTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGATTGA
AGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTTCTAGGCCATTATCAAGAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGGAACA
TGCTGATGGTCTTCTTAAGGATTTAATGAGAGCATCTTATCCTTGCATGTCTCTTCATGGAGGCATTGATCAATATGACAGAGATAGCAT
CATAAATGACTTTAAGAATGGGACCTGCAAACTTCTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTCTTGT
AGTAAATTATAGCTGCCCCAACCATTATGAGGATTATGTACACAGAGCAGGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTTATAC
TTTTATCACAGAGGATCAAGCTCGCTATGCTGGTGACATAATTAAAGCTCTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAGAGAA
ACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCTGAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGTTTGA
TGAAACAGAACAAGCTTTGGCTAATGAGAGGAAGAAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTGCAGT
TGATATTGATGAGCAAATTGAAAGCATGTTTAATTCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTGCTCC
AACTGCAGGAAATGCTGAGAAATTAGAAATTGCTAAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTCAGGA
TGTGATGCAGCAGGCCACCAATGCAATTCTTAGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAACTTGC
TGAAAAGATCAATGCCAAGCTCAATTATGTGCCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTAAGAG
ATATGAAGAAGAATTAGAGATCAATGACTTCCCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTGAATA
CTCTGAAGCCGCAATTACAATCAGAGGAACCTACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAATTGA
AAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCATACCA
ACCAACAAATAAAGGAAGATACAAAGTCTTATAGACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGTTGCT
GTCTGCAGTTTACAATGTATTGTAAATGAAGATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGGTAAA
GAAATCTGTCCGTAAGTACCCCCACAATCAGTCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAACTCA
AATATCAATATTTTAAATGTCCGGATAATATTCTAGAGGTTTAAAAAATGGAAATATTTGAACTTTCTATTGAAGACAATAAAGTACACA
AGTCGTTAAGGGGCTATTCACTTTATCCTGTACTTTCAATGAAATTGTGATCATTTCCTAAGAAAAGGTAAAATTCACTATCATATTTTG
TGTCCCCACCTTGATGTTACATGACTCTGGAACAATATGAACTGGATTTAAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGAGAGT

>16735_16735_1_CHSY3-DDX46_CHSY3_chr5_129244053_ENST00000305031_DDX46_chr5_134130540_ENST00000354283_length(amino acids)=851AA_BP=362
MAVRSRRPWMSVALGLVLGFTAASWLIAPRVAELSERKRRGSSLCSYYGRSAAGPRAGAQQPLPQPQSRPRQEQSPPPARQDLQGPPLPE
AAPGITSFRSSPWQQPPPLQQRRRGREPEGATGLPGAPAAEGEPEEEDGGAAGQRRDGRPGSSHNGSGDGGAAAPSARPRDFLYVGVMTA
QKYLGSRALAAQRTWARFIPGRVEFFSSQQPPNAGQPPPPLPVIALPGVDDSYPPQKKSFMMIKYMHDHYLDKYEWFMRADDDVYIKGDK
LEEFLRSLNSSKPLYLGQTGLGNIEELGKLGLEPGENFCMGGPGMIFSREVLRRMVPHIGECLREMYTTHEDVEVGRCVRRFGGTQCVWS
YEVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQE
HADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAY
TFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAA
VDIDEQIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIAEQL
AEKINAKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAI

--------------------------------------------------------------
>16735_16735_2_CHSY3-DDX46_CHSY3_chr5_129244053_ENST00000305031_DDX46_chr5_134130540_ENST00000452510_length(transcript)=5349nt_BP=1444nt
GGGTGGCAGCCTAGGAGCGGACGCGTTGCCGCCGCCGCTGCTCCTCCTCCTCCTCCTGCAGCTCCTCCAGCTGCCGCTGCTGCCGCCGCT
GCCGCCACCGCCGCCGCCGGGAGAAGTTTCACTCCCGACCCTTGCTCGGAGCCCCGGCCCAGAGCTGAGCGGGAGCCCGGCAGGCAGCTG
CAGCCCGCGGCAGTCGAGGCGTCCGCGGCGCTTCGACCTCCAGCCGGTGTCGGCGCCTAGGCGGCCGGCTGCGGCCGCGGCTGGGGGCGC
AAAGGCGGAGGAGGGGCGGGTGTGAGCCGGGGAAACCGCGTGCCGCGCCGCGACAGCCCAGCGAGCGTCCGCGCCCGGGACAGCCGCGAT
GGCTGTGCGCTCTCGCCGCCCGTGGATGAGCGTGGCATTAGGGCTGGTGCTGGGCTTCACCGCCGCGTCCTGGCTCATCGCCCCCAGGGT
GGCGGAGCTGAGCGAGAGGAAGAGACGTGGCTCCAGCCTCTGCTCCTACTACGGTCGCTCTGCTGCTGGCCCCCGCGCCGGCGCTCAGCA
GCCGCTCCCCCAGCCCCAGTCCCGACCACGGCAGGAGCAGTCGCCGCCCCCCGCGCGCCAGGATCTCCAGGGGCCACCGCTGCCCGAGGC
AGCACCCGGGATCACCAGTTTTCGAAGCAGCCCCTGGCAGCAGCCACCTCCGCTGCAGCAGCGGCGGCGAGGACGCGAGCCTGAGGGCGC
GACGGGGCTTCCCGGTGCTCCAGCGGCCGAGGGGGAGCCCGAGGAGGAGGACGGGGGCGCGGCTGGGCAGCGGAGAGACGGCCGGCCGGG
GAGTAGCCACAACGGCAGCGGGGACGGGGGCGCTGCCGCCCCGAGCGCCCGACCCCGGGACTTCCTGTACGTGGGGGTGATGACCGCGCA
GAAGTACCTGGGCAGCCGCGCGCTGGCCGCGCAGCGGACCTGGGCGCGTTTCATCCCGGGCCGCGTGGAGTTCTTTTCCAGCCAGCAGCC
CCCCAACGCCGGCCAGCCCCCGCCACCCCTGCCTGTCATCGCGCTACCGGGTGTGGACGACTCCTATCCTCCCCAGAAAAAGTCCTTCAT
GATGATCAAGTACATGCACGACCACTACCTGGACAAGTATGAGTGGTTCATGCGCGCCGACGACGATGTCTACATCAAAGGTGATAAATT
AGAAGAGTTTCTTAGATCGCTAAACAGCAGTAAGCCTCTCTACCTGGGACAGACTGGCCTGGGGAATATTGAAGAGCTTGGAAAGCTGGG
ACTGGAGCCTGGGGAAAACTTCTGTATGGGAGGACCTGGCATGATCTTTAGCCGAGAAGTTCTCAGGAGGATGGTGCCACATATTGGTGA
ATGCCTTAGAGAAATGTACACGACTCATGAGGATGTGGAAGTAGGAAGATGCGTTCGCCGTTTTGGTGGGACTCAGTGTGTCTGGTCTTA
CGAGGTCATGCGCATCGTGGATAATGTTCGTCCTGATCGACAGACGGTTATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTTTGGC
TCGCAGGATCCTCAGTAAACCTATTGAAGTACAAGTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGATTGA
AGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTTCTAGGCCATTATCAAGAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGGAACA
TGCTGATGGTCTTCTTAAGGATTTAATGAGAGCATCTTATCCTTGCATGTCTCTTCATGGAGGCATTGATCAATATGACAGAGATAGCAT
CATAAATGACTTTAAGAATGGGACCTGCAAACTTCTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTCTTGT
AGTAAATTATAGCTGCCCCAACCATTATGAGGATTATGTACACAGAGCAGGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTTATAC
TTTTATCACAGAGGATCAAGCTCGCTATGCTGGTGACATAATTAAAGCTCTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAGAGAA
ACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCTGAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGTTTGA
TGAAACAGAACAAGCTTTGGCTAATGAGAGGAAGAAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTGCAGT
TGATATTGATGAGCAAATTGAAAGCATGTTTAATTCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTGCTCC
AACTGCAGGAAATGCTGAGAAATTAGAAATTGCTAAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTCAGGT
AGATGTGATGCAGCAGGCCACCAATGCAATTCTTAGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAACT
TGCTGAAAAGATCAATGCCAAGCTCAATTATGTGCCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTAA
GAGATATGAAGAAGAATTAGAGATCAATGACTTCCCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTGA
ATACTCTGAAGCCGCAATTACAATCAGAGGAACCTACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAAT
TGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCATA
CCAACCAACAAATAAAGGAAGATACAAAGTCTTATAGACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGTT
GCTGTCTGCAGTTTACAATGTATTGTAAATGAAGATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGGT
AAAGAAATCTGTCCGTAAGTACCCCCACAATCAGTCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAAC
TCAAATATCAATATTTTAAATGTCCGGATAATATTCTAGAGGTTTAAAAAATGGAAATATTTGAACTTTCTATTGAAGACAATAAAGTAC
ACAAGTCGTTAAGGGGCTATTCACTTTATCCTGTACTTTCAATGAAATTGTGATCATTTCCTAAGAAAAGGTAAAATTCACTATCATATT
TTGTGTCCCCACCTTGATGTTACATGACTCTGGAACAATATGAACTGGATTTAAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGAG
AGTTTTTGTTTCAATTTTTATCATCATAAATGGGCAAAAAGTAGTTGGACTAATTTCGGTTTTTATACAAGTAAAGATTTAATAGTATAA
GGATTTTTTTGCATTTCTTTACACTGAGTGTAAAACTCTACAAAGAGTTATAGTATTTACTACTTTGAGGTTTCCCTCACAACTTCTGGC
TCCATACCTAGCCCCTCTTTTATAATCTTCCTTAAAAGAAAGAGTGTAGCCTATAAATACTAAATATGATACCTTTTCCTTCTAGAAAGT
GTTTATTTATATATCTATACATGTTGTATGTACAAATATCCTACTACTTTTAATCTGATTTTTCTTCAGGATTATTGAGTAGGTTGTGAA
TTTTCTTTCTTAAAAATTGTAAAACATAATGGTACCCAAGTTTTAAACTTAGATGTGCTTCATCTTAGTGAAATTTAATTCACAAGGAAT
CATAAATTGTGTTTTTGAGGCTGGGCGCAGTGACTCACACCTGTATCCCAGCAATTTGGGAGGCCGAGGTGGGCAGATCACTTGAGGTCA
GGAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGTCGGCATGGTGGTGGGTGGCTGTAAT
CCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCTGAGCCAAGATAACACCATTGCACTCCAGCCTGGGCGACAGAGTGAGACTATCTCAA
AAATAAATAAATAAATAAATAAATAGTATTTTTGAGCCTTCAAGATACAGTTCCTGAATATTCTAATTTAAATTGTTATAATTGGATTAC
CTAATATTCTTTTCAAGACTCCTGATGTATTAACTTCATGTTATTGTCACTTTTCAAAAAAGGAATTTTTTTCAGGAGTTAAATAAAGTC
AGTCTTTTATATCCAAGGGTTTCAAACCCACAGATTAAACCAACCACAGATCAAAAATAGAAAAAAAAAAAAAAAGAAAAAAAGAATGTA
AAATTTTAAAAATACAGTTTAACAGCTGTAAAAGTTTTACTATAACATTTACATTGTGTTAGGTATTTTAAGTAATTTAAAGGTTACAGT
ATACAGGCGGTTAAAGTATACAGGAGGATGTGCATCGGTTATATGCATATAGCAAGCCATTTCATATAAGAGGCTTGAACATCCATGGAT
TTTGGTATAGAGGAGGGGTTTAAGGGGTGTCCTGCAATCAGTCCCCCTCTCATACCAAAGGATGACTGTATATTTCTTAAATGAAGAGAC
TTTCATTCTTTAAATATTATTGACTTACAGTTTAAAAATAAATAAATAAAAGCATACTATAGTTGTAAAAACAAATAATTTTAATAGTAT
ATTCAGTGGCTGAAGTGATAGGGAGTATTAATCATTATTTCTTCAGTATAAAGTTATTCTTCCTGAAAAAGTAAGATATACCTGGGAAAT
ATTCTTGGATCCTTCACACATCCACTTAATTTCTTGAAGGAAGAAAACAGACAAAAGACATGTAACAACAGAAACAAATAAACCACTTAC
TGTAAAATTTCAGAAATTGTGGGCTCATTCCCTCCCTCTAGTTTATTTATTTGCTCATCTTTATCACCTAATGGTAGTTTGTTTTCTTTG
GTAGAGTATATGGCAGTCCCACATCGATGATAATTGGTGCTCCCTTCATCCAACTGGATCACTTTGAGATTCAGTTTTACATCATTTTAG
CATTTTGTTTGTATATCAGTTGTGATGAGCCACTGATAAAATTTTGTTCTAAAATGAAACATATTACTTTGTTAGTACATTTTTTAGTGT
CACACTGACTTTTAAAATTTGAATGATATATAGACTTTGTTTTTTTAATGCAATATGAATATTTGCTCATGTTTTCTAAATTCCTTATAA

>16735_16735_2_CHSY3-DDX46_CHSY3_chr5_129244053_ENST00000305031_DDX46_chr5_134130540_ENST00000452510_length(amino acids)=852AA_BP=362
MAVRSRRPWMSVALGLVLGFTAASWLIAPRVAELSERKRRGSSLCSYYGRSAAGPRAGAQQPLPQPQSRPRQEQSPPPARQDLQGPPLPE
AAPGITSFRSSPWQQPPPLQQRRRGREPEGATGLPGAPAAEGEPEEEDGGAAGQRRDGRPGSSHNGSGDGGAAAPSARPRDFLYVGVMTA
QKYLGSRALAAQRTWARFIPGRVEFFSSQQPPNAGQPPPPLPVIALPGVDDSYPPQKKSFMMIKYMHDHYLDKYEWFMRADDDVYIKGDK
LEEFLRSLNSSKPLYLGQTGLGNIEELGKLGLEPGENFCMGGPGMIFSREVLRRMVPHIGECLREMYTTHEDVEVGRCVRRFGGTQCVWS
YEVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQE
HADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAY
TFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAA
VDIDEQIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTIAEQ
LAEKINAKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLA

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Fusion Gene PPI Analysis for CHSY3-DDX46


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHSY3-DDX46


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHSY3-DDX46


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource