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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ICAM1-RTN4 (FusionGDB2 ID:HG3383TG57142) |
Fusion Gene Summary for ICAM1-RTN4 |
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Fusion gene information | Fusion gene name: ICAM1-RTN4 | Fusion gene ID: hg3383tg57142 | Hgene | Tgene | Gene symbol | ICAM1 | RTN4 | Gene ID | 3383 | 57142 |
Gene name | intercellular adhesion molecule 1 | reticulon 4 | |
Synonyms | BB2|CD54|P3.58 | ASY|NI220/250|NOGO|NSP|NSP-CL|Nbla00271|Nbla10545|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-C | |
Cytomap | ('ICAM1')('RTN4') 19p13.2 | 2p16.1 | |
Type of gene | protein-coding | protein-coding | |
Description | intercellular adhesion molecule 1ICAM-1cell surface glycoprotein P3.58epididymis secretory sperm binding proteinintercellular adhesion molecule 1 (CD54), human rhinovirus receptormajor group rhinovirus receptor | reticulon-4Human NogoAMy043 proteinfoocenneurite growth inhibitor 220neurite outgrowth inhibitorneuroendocrine-specific protein C homologreticulon 5 | |
Modification date | 20200329 | 20200327 | |
UniProtAcc | P05362 | . | |
Ensembl transtripts involved in fusion gene | ENST00000264832, ENST00000423829, ENST00000585443, | ||
Fusion gene scores | * DoF score | 8 X 6 X 5=240 | 27 X 28 X 9=6804 |
# samples | 9 | 35 | |
** MAII score | log2(9/240*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(35/6804*10)=-4.28095631383106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ICAM1 [Title/Abstract] AND RTN4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ICAM1(10381644)-RTN4(55200230), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ICAM1 | GO:0007155 | cell adhesion | 16809613 |
Hgene | ICAM1 | GO:0044406 | adhesion of symbiont to host | 2538243 |
Hgene | ICAM1 | GO:0046813 | receptor-mediated virion attachment to host cell | 2538243 |
Hgene | ICAM1 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 |
Hgene | ICAM1 | GO:1904646 | cellular response to amyloid-beta | 11078691 |
Hgene | ICAM1 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 |
Tgene | RTN4 | GO:0030517 | negative regulation of axon extension | 10667797 |
Tgene | RTN4 | GO:0071787 | endoplasmic reticulum tubular network formation | 24262037|25612671 |
Tgene | RTN4 | GO:1905552 | positive regulation of protein localization to endoplasmic reticulum | 27353365 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for ICAM1-RTN4 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ICAM1-RTN4 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ICAM1-RTN4 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:10381644/:55200230) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ICAM1 | . |
FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742}.; FUNCTION: (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. {ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:9539703}.; FUNCTION: (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. {ECO:0000269|PubMed:11413168}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ICAM1-RTN4 |
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Fusion Gene PPI Analysis for ICAM1-RTN4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ICAM1-RTN4 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ICAM1 | P05362 | DB00108 | Natalizumab | Biotech | Approved|Investigational | |
Hgene | ICAM1 | P05362 | DB08818 | Hyaluronic acid | Small molecule | Approved|Vet_approved |
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Related Diseases for ICAM1-RTN4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ICAM1 | C0002152 | Alloxan Diabetes | 3 | CTD_human |
Hgene | ICAM1 | C0011853 | Diabetes Mellitus, Experimental | 3 | CTD_human |
Hgene | ICAM1 | C0038433 | Streptozotocin Diabetes | 3 | CTD_human |
Hgene | ICAM1 | C0004096 | Asthma | 2 | CTD_human |
Hgene | ICAM1 | C0004943 | Behcet Syndrome | 2 | CTD_human |
Hgene | ICAM1 | C0007102 | Malignant tumor of colon | 2 | CTD_human |
Hgene | ICAM1 | C0007222 | Cardiovascular Diseases | 2 | CTD_human |
Hgene | ICAM1 | C0007786 | Brain Ischemia | 2 | CTD_human |
Hgene | ICAM1 | C0009375 | Colonic Neoplasms | 2 | CTD_human |
Hgene | ICAM1 | C0019284 | Diaphragmatic Hernia | 2 | CTD_human |
Hgene | ICAM1 | C0020538 | Hypertensive disease | 2 | CTD_human |
Hgene | ICAM1 | C0021368 | Inflammation | 2 | CTD_human |
Hgene | ICAM1 | C0035126 | Reperfusion Injury | 2 | CTD_human |
Hgene | ICAM1 | C0242488 | Acute Lung Injury | 2 | CTD_human |
Hgene | ICAM1 | C0917798 | Cerebral Ischemia | 2 | CTD_human |
Hgene | ICAM1 | C0004153 | Atherosclerosis | 1 | CTD_human |
Hgene | ICAM1 | C0006267 | Bronchiectasis | 1 | CTD_human |
Hgene | ICAM1 | C0008370 | Cholestasis | 1 | CTD_human |
Hgene | ICAM1 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
Hgene | ICAM1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Hgene | ICAM1 | C0011884 | Diabetic Retinopathy | 1 | CTD_human |
Hgene | ICAM1 | C0020443 | Hypercholesterolemia | 1 | CTD_human |
Hgene | ICAM1 | C0021390 | Inflammatory Bowel Diseases | 1 | CTD_human |
Hgene | ICAM1 | C0026640 | Mouth Neoplasms | 1 | CTD_human |
Hgene | ICAM1 | C0026769 | Multiple Sclerosis | 1 | CTD_human |
Hgene | ICAM1 | C0027051 | Myocardial Infarction | 1 | CTD_human |
Hgene | ICAM1 | C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human |
Hgene | ICAM1 | C0027720 | Nephrosis | 1 | CTD_human |
Hgene | ICAM1 | C0028754 | Obesity | 1 | CTD_human |
Hgene | ICAM1 | C0032231 | Pleurisy | 1 | CTD_human |
Hgene | ICAM1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | ICAM1 | C0035235 | Respiratory Syncytial Virus Infections | 1 | CTD_human |
Hgene | ICAM1 | C0035309 | Retinal Diseases | 1 | CTD_human |
Hgene | ICAM1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | ICAM1 | C0036982 | Shock, Hemorrhagic | 1 | CTD_human |
Hgene | ICAM1 | C0038454 | Cerebrovascular accident | 1 | CTD_human |
Hgene | ICAM1 | C0041948 | Uremia | 1 | CTD_human |
Hgene | ICAM1 | C0042109 | Urticaria | 1 | CTD_human |
Hgene | ICAM1 | C0085129 | Bronchial Hyperreactivity | 1 | CTD_human |
Hgene | ICAM1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | ICAM1 | C0153381 | Malignant neoplasm of mouth | 1 | CTD_human |
Hgene | ICAM1 | C0238281 | Middle Cerebral Artery Syndrome | 1 | CTD_human |
Hgene | ICAM1 | C0282548 | Leukostasis | 1 | CTD_human |
Hgene | ICAM1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Hgene | ICAM1 | C0740376 | Middle Cerebral Artery Thrombosis | 1 | CTD_human |
Hgene | ICAM1 | C0740391 | Middle Cerebral Artery Occlusion | 1 | CTD_human |
Hgene | ICAM1 | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
Hgene | ICAM1 | C0751324 | Multiple Sclerosis, Acute Fulminating | 1 | CTD_human |
Hgene | ICAM1 | C0751845 | Middle Cerebral Artery Embolus | 1 | CTD_human |
Hgene | ICAM1 | C0751846 | Left Middle Cerebral Artery Infarction | 1 | CTD_human |
Hgene | ICAM1 | C0751847 | Embolic Infarction, Middle Cerebral Artery | 1 | CTD_human |
Hgene | ICAM1 | C0751848 | Thrombotic Infarction, Middle Cerebral Artery | 1 | CTD_human |
Hgene | ICAM1 | C0751849 | Right Middle Cerebral Artery Infarction | 1 | CTD_human |
Hgene | ICAM1 | C0751956 | Acute Cerebrovascular Accidents | 1 | CTD_human |
Hgene | ICAM1 | C1563937 | Atherogenesis | 1 | CTD_human |
Hgene | ICAM1 | C4721453 | Peripheral Nervous System Diseases | 1 | CTD_human |
Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
Tgene | C0036341 | Schizophrenia | 1 | CTD_human |