Fusion Gene Studies
in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APOC1-LAMA1 (FusionGDB2 ID:HG341TG284217)

Fusion Gene Summary for APOC1-LAMA1

check button Fusion gene summary
Fusion gene informationFusion gene name: APOC1-LAMA1
Fusion gene ID: hg341tg284217
HgeneTgene
Gene symbol

APOC1

LAMA1

Gene ID

341

284217

Gene nameapolipoprotein C1laminin subunit alpha 1
SynonymsApo-CI|ApoC-I|apo-CIB|apoC-IBLAMA|PTBHS|S-LAM-alpha
Cytomap('APOC1')('LAMA1')

19q13.32

18p11.31

Type of geneprotein-codingprotein-coding
Descriptionapolipoprotein C-Ilaminin subunit alpha-1S-LAM alphaS-laminin subunit alphalaminin A chainlaminin, alpha 1laminin-3 subunit alpha
Modification date2020031320200320
UniProtAcc

P02654

.
Ensembl transtripts involved in fusion geneENST00000252491, ENST00000588750, 
ENST00000588802, ENST00000586638, 
ENST00000592885, ENST00000589781, 
Fusion gene scores* DoF score5 X 3 X 4=607 X 8 X 3=168
# samples 56
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/168*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APOC1 [Title/Abstract] AND LAMA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPOC1(45419584)-LAMA1(7042250), # samples:1
Anticipated loss of major functional domain due to fusion event.APOC1-LAMA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APOC1-LAMA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APOC1-LAMA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APOC1-LAMA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPOC1

GO:0010900

negative regulation of phosphatidylcholine catabolic process

2302419

HgeneAPOC1

GO:0010916

negative regulation of very-low-density lipoprotein particle clearance

1917954

HgeneAPOC1

GO:0032375

negative regulation of cholesterol transport

10978346

HgeneAPOC1

GO:0033344

cholesterol efflux

11162594

HgeneAPOC1

GO:0033700

phospholipid efflux

11162594

HgeneAPOC1

GO:0034369

plasma lipoprotein particle remodeling

10978346

HgeneAPOC1

GO:0034382

chylomicron remnant clearance

4020294

HgeneAPOC1

GO:0045717

negative regulation of fatty acid biosynthetic process

15576844

HgeneAPOC1

GO:0045833

negative regulation of lipid metabolic process

182536

HgeneAPOC1

GO:0048261

negative regulation of receptor-mediated endocytosis

1917954

HgeneAPOC1

GO:0050995

negative regulation of lipid catabolic process

15576844

HgeneAPOC1

GO:0051005

negative regulation of lipoprotein lipase activity

15576844


check buttonFusion gene breakpoints across APOC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LAMA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for APOC1-LAMA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000592885ENST00000389658APOC1chr1945419584+LAMA1chr187042250-0.0005000820.9994999
ENST00000586638ENST00000389658APOC1chr1945419584+LAMA1chr187042250-0.0004769250.99952304

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Fusion Genomic Features for APOC1-LAMA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for APOC1-LAMA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:45419584/chr18:7042250)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APOC1

P02654

.
FUNCTION: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein. {ECO:0000269|PubMed:17339654, ECO:0000303|PubMed:25160599}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587631706_17833853076.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587631044_10893853076.0DomainLaminin EGF-like 12
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587631090_11493853076.0DomainLaminin EGF-like 13
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587631150_11593853076.0DomainLaminin EGF-like 14%3B first part
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587631170_13613853076.0DomainLaminin IV type A 2
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587631362_14023853076.0DomainLaminin EGF-like 14%3B second part
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587631403_14513853076.0DomainLaminin EGF-like 15
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587631452_15083853076.0DomainLaminin EGF-like 16
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587631509_15553853076.0DomainLaminin EGF-like 17
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587632117_22973853076.0DomainLaminin G-like 1
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587632305_24813853076.0DomainLaminin G-like 2
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587632486_26733853076.0DomainLaminin G-like 3
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587632713_28853853076.0DomainLaminin G-like 4
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587632890_30703853076.0DomainLaminin G-like 5
TgeneLAMA1chr19:45419584chr18:7042250ENST00000389658763397_4533853076.0DomainLaminin EGF-like 3
TgeneLAMA1chr19:45419584chr18:7042250ENST00000389658763454_5023853076.0DomainLaminin EGF-like 4
TgeneLAMA1chr19:45419584chr18:7042250ENST00000389658763503_5123853076.0DomainLaminin EGF-like 5%3B first part
TgeneLAMA1chr19:45419584chr18:7042250ENST00000389658763516_7083853076.0DomainLaminin IV type A 1
TgeneLAMA1chr19:45419584chr18:7042250ENST00000389658763709_7413853076.0DomainLaminin EGF-like 5%3B second part
TgeneLAMA1chr19:45419584chr18:7042250ENST00000389658763742_7903853076.0DomainLaminin EGF-like 6
TgeneLAMA1chr19:45419584chr18:7042250ENST00000389658763791_8483853076.0DomainLaminin EGF-like 7
TgeneLAMA1chr19:45419584chr18:7042250ENST00000389658763849_9013853076.0DomainLaminin EGF-like 8
TgeneLAMA1chr19:45419584chr18:7042250ENST00000389658763902_9503853076.0DomainLaminin EGF-like 9
TgeneLAMA1chr19:45419584chr18:7042250ENST00000389658763951_9973853076.0DomainLaminin EGF-like 10
TgeneLAMA1chr19:45419584chr18:7042250ENST00000389658763998_10433853076.0DomainLaminin EGF-like 11
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587632534_25363853076.0MotifNote=Cell attachment site
TgeneLAMA1chr19:45419584chr18:7042250ENST000003896587631556_21163853076.0RegionNote=Domain II and I

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLAMA1chr19:45419584chr18:7042250ENST0000038965876318_2693853076.0DomainLaminin N-terminal
TgeneLAMA1chr19:45419584chr18:7042250ENST00000389658763270_3263853076.0DomainLaminin EGF-like 1
TgeneLAMA1chr19:45419584chr18:7042250ENST00000389658763327_3963853076.0DomainLaminin EGF-like 2


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Fusion Gene Sequence for APOC1-LAMA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5554_5554_1_APOC1-LAMA1_APOC1_chr19_45419584_ENST00000586638_LAMA1_chr18_7042250_ENST00000389658_length(transcript)=8521nt_BP=113nt
CAGAGTGCCCCTCCGGCCTCGCCATGAGGCTCTTCCTGTCGCTCCCGGTCCTGGTGGTGGTTCTGTCGATCGTCTTGGAAGTAGAACCCT
TCCCAGGGCACGGGAGAGCTGGGGTGTCTCCTTATGAGGATGAGCCTTGCCGCCCCTGTAATTGTGACCCTGTGGGGTCCCTCAGTTCTG
TCTGTATTAAGGATGACCTCCATTCTGACTTACACAATGGGAAGCAGCCAGGTCAGTGCCCATGTAAGGAAGGTTATACAGGAGAAAAAT
GTGATCGCTGCCAACTTGGCTATAAGGATTACCCGACCTGTGTCTCCTGTGGGTGCAACCCAGTGGGCAGTGCCAGTGATGAGCCCTGCA
CAGGGCCCTGTGTTTGTAAGGAAAACGTTGAGGGGAAGGCCTGTGATCGCTGCAAGCCAGGATTCTATAACTTGAAGGAAAAAAACCCCC
GGGGCTGCTCCGAGTGCTTCTGCTTTGGCGTTTCTGATGTCTGCAGCAGCCTCTCTTGGCCTGTTGGTCAGGTAAACAGTATGTCCGGGT
GGCTGGTCACCGACTTGATCAGTCCCAGGAAGATCCCGTCTCAGCAAGATGCACTAGGCGGGCGCCATCAGGTCAGCATCAACAACACCG
CGGTCATGCAGAGACTGGCTCCCAAGTACTACTGGGCAGCCCCCGAGGCCTACCTTGGAAATAAGCTGACTGCGTTTGGCGGATTCCTGA
AATACACGGTGTCCTACGATATTCCGGTAGAGACGGTAGACAGTAACCTCATGTCGCATGCTGACGTCATCATTAAGGGAAACGGACTCA
CTTTAAGCACACAGGCTGAGGGTCTGTCATTGCAGCCTTATGAAGAGTACCTAAACGTGGTTAGACTTGTGCCTGAAAACTTCCAAGATT
TTCACAGCAAAAGGCAGATTGATCGTGACCAGCTGATGACTGTCCTTGCCAATGTGACACATCTTTTGATCAGAGCCAACTACAATTCTG
CAAAAATGGCTCTTTACAGGTTGGAGTCCGTCTCTCTGGACATAGCCAGCTCTAATGCCATCGACCTGGTGGTGGCCGCTGATGTGGAGC
ACTGTGAATGTCCGCAAGGCTACACAGGGACCTCCTGTGAGTCGTGCCTCTCTGGCTATTACCGCGTGGATGGAATACTCTTTGGAGGAA
TTTGTCAACCCTGTGAATGCCACGGCCATGCAGCTGAGTGTAATGTTCACGGCGTTTGCATTGCGTGTGCGCACAACACCACCGGCGTCC
ACTGTGAGCAGTGCTTGCCCGGCTTCTACGGGGAGCCTTCCCGAGGGACACCTGGGGACTGCCAGCCCTGCGCCTGCCCTCTCACCATAG
CCTCCAACAATTTCAGCCCCACCTGCCACCTCAATGATGGAGATGAAGTGGTCTGTGACTGGTGTGCCCCGGGCTACTCAGGAGCTTGGT
GTGAGAGATGTGCAGATGGTTACTATGGAAACCCAACAGTGCCTGGCGAATCTTGTGTTCCCTGTGACTGCAGCGGCAACGTGGACCCCT
CGGAGGCTGGTCACTGTGACTCAGTCACCGGGGAGTGCCTGAAGTGCCTGGGGAACACAGATGGCGCCCACTGTGAAAGGTGTGCTGACG
GGTTCTATGGGGACGCTGTGACAGCCAAGAACTGCCGCGCCTGTGAATGCCATGTGAAAGGCTCCCATTCTGCCGTGTGCCATCTTGAGA
CCGGGCTCTGTGACTGCAAACCAAACGTGACTGGACAGCAGTGTGACCAGTGCTTGCATGGCTATTATGGGCTGGACTCAGGCCATGGCT
GCCGGCCCTGCAACTGCAGCGTGGCAGGCTCCGTGTCAGATGGCTGCACGGATGAAGGCCAGTGTCACTGTGTCCCAGGTGTGGCAGGGA
AAAGGTGTGACAGGTGTGCCCATGGCTTCTACGCCTACCAGGATGGTAGCTGTACACCCTGTGACTGCCCACACACTCAGAATACCTGCG
ACCCAGAAACTGGAGAGTGTGTCTGCCCCCCTCACACACAGGGTGTGAAGTGTGAAGAATGTGAGGATGGGCACTGGGGCTACGATGCGG
AGGTGGGGTGCCAGGCCTGCAATTGCAGTCTCGTGGGGTCGACTCATCATCGGTGCGATGTGGTCACCGGCCATTGCCAGTGCAAGTCAA
AATTTGGTGGCCGGGCCTGCGATCAGTGTTCCTTGGGTTACAGAGACTTTCCCGACTGTGTTCCCTGTGACTGTGACCTGAGGGGGACGT
CGGGGGACGCCTGCAACCTGGAGCAGGGTCTCTGCGGCTGTGTGGAGGAAACCGGGGCCTGCCCTTGCAAGGAAAATGTCTTTGGTCCTC
AGTGCAACGAATGTCGAGAGGGCACCTTCGCTCTCCGCGCAGACAACCCCCTGGGCTGCAGCCCGTGCTTCTGCTCCGGGCTGTCCCACC
TCTGCTCAGAGCTGGAGGACTACGTGAGGACCCCAGTAACGCTGGGCTCCGATCAGCCTCTTCTGCGTGTGGTTTCTCAGAGTAACTTGA
GGGGCACGACCGAGGGGGTTTACTACCAGGCCCCCGACTTCCTGCTGGATGCCGCCACCGTCCGGCAGCACATCCGTGCAGAGCCGTTTT
ACTGGCGGCTGCCGCAGCAGTTCCAAGGAGACCAGCTCATGGCCTATGGTGGCAAACTGAAGTACAGCGTGGCCTTCTATTCTTTGGATG
GCGTCGGCACCTCCAATTTTGAGCCTCAAGTTCTCATCAAAGGTGGTCGGATCAGAAAGCAAGTCATTTACATGGATGCACCAGCCCCAG
AGAATGGAGTGAGACAGGAACAAGAAGTAGCAATGAGAGAGAATTTTTGGAAATATTTTAACTCTGTTTCTGAAAAACCTGTCACGCGAG
AGGATTTTATGTCTGTCCTCAGCGATATTGAGTACATCCTCATCAAGGCATCGTATGGTCAAGGATTACAGCAGAGCAGAATCTCAGACA
TTTCAATGGAGGTTGGCAGAAAGGCTGAAAAGCTGCACCCAGAAGAAGAGGTTGCATCTCTTTTAGAGAATTGTGTCTGTCCTCCTGGCA
CTGTGGGATTCTCATGTCAGGACTGCGCCCCTGGGTACCACAGAGGGAAGCTCCCAGCAGGGAGTGACAGGGGACCACGCCCTCTGGTTG
CTCCTTGTGTTCCCTGCAGTTGCAACAACCACAGTGACACCTGTGACCCCAACACCGGGAAGTGTCTGAACTGTGGCGATAACACAGCAG
GTGACCATTGTGATGTGTGTACTTCTGGCTACTACGGGAAGGTGACTGGCTCAGCAAGTGACTGTGCTCTGTGTGCCTGTCCTCACAGCC
CTCCTGCCAGTTTTAGTCCCACTTGTGTCTTGGAAGGGGACCACGATTTCCGTTGTGACGCCTGTCTCCTGGGCTATGAAGGAAAACACT
GTGAAAGGTGCTCCTCAAGCTATTATGGGAACCCTCAAACACCAGGTGGCAGTTGCCAGAAGTGTGACTGCAACCCGCACGGCTCTGTCC
ACGGTGACTGTGACCGCACATCTGGGCAGTGCGTTTGCAGGCTGGGGGCCTCGGGGCTCCGGTGCGATGAGTGTGAACCGAGGCACATTC
TGATGGAAACAGATTGTGTTTCCTGTGATGATGAGTGTGTAGGTGTGCTGCTGAATGACTTGGATGAGATTGGTGATGCCGTTCTTTCTC
TGAACCTCACTGGCATTATCCCTGTCCCATATGGAATTTTGTCAAACCTGGAAAATACAACTAAATATCTCCAGGAATCTTTATTAAAAG
AAAATATGCAAAAGGACCTGGGAAAAATTAAGCTTGAAGGTGTTGCAGAAGAAACGGACAACCTGCAAAAGAAGCTCACTAGGATGTTAG
CGAGTACCCAAAAGGTGAATAGGGCAACTGAGAGAATCTTCAAGGAGAGTCAAGACCTGGCCATAGCCATTGAGAGGCTGCAGATGAGCA
TCACAGAAATTATGGAAAAGACAACTTTAAATCAGACTTTGGATGAAGATTTCCTACTACCCAATTCTACTCTTCAGAACATGCAACAGA
ATGGTACATCTTTGCTAGAAATCATGCAGATAAGAGACTTCACACAGTTGCACCAAAATGCCACCCTTGAACTCAAGGCTGCTGAAGATT
TATTGTCACAAATTCAGGAAAATTACCAGAAGCCGCTGGAAGAATTGGAGGTATTGAAAGAAGCAGCAAGCCACGTCCTTTCAAAGCACA
ACAATGAACTAAAGGCGGCTGAGGCGCTCGTGAGGGAAGCTGAGGCAAAGATGCAGGAAAGCAACCACCTGCTGCTCATGGTCAATGCTA
ATCTGAGAGAATTCAGTGATAAAAAGCTGCATGTTCAAGAAGAACAAAATCTGACCTCAGAGCTCATTGTCCAAGGAAGAGGATTGATAG
ATGCTGCTGCTGCACAAACAGATGCTGTACAAGATGCTCTAGAGCACTTAGAGGATCACCAGGATAAGCTACTTTTATGGTCTGCCAAAA
TCAGGCACCACATAGATGACCTGGTCATGCACATGTCCCAAAGGAACGCAGTCGACCTGGTCTACAGAGCTGAGGACCATGCCGCTGAGT
TCCAGAGACTAGCAGATGTTCTGTACAGTGGCCTTGAAAACATCAGAAATGTGTCCCTGAATGCCACCAGTGCAGCCTATGTCCATTACA
ACATCCAGAGCCTGATTGAAGAATCGGAGGAACTGGCCAGAGATGCTCACAGGACTGTGACTGAGACGAGCCTGCTCTCAGAATCCCTTG
TTTCTAACGGGAAAGCGGCCGTGCAGCGCAGCTCCAGATTTCTAAAAGAAGGCAACAACCTCAGCAGGAAGCTTCCAGGTATTGCATTGG
AACTGAGTGAATTGAGAAATAAGACAAACAGATTTCAAGAGAATGCTGTTGAAATTACCAGGCAAACCAATGAATCACTCTTGATACTTA
GAGCAATTCCTAAAGGTATAAGAGACAAGGGAGCCAAAACCAAAGAGCTGGCCACGTCTGCAAGCCAGAGCGCGGTGAGCACGCTGAGGG
ACGTGGCGGGGCTGAGCCAGGAGCTGCTGAACACATCTGCCAGCCTGTCCAGGGTCAACACCACATTACGAGAGACACACCAGCTTCTGC
AGGACTCCACCATGGCCACTCTGTTGGCTGGAAGAAAAGTCAAAGACGTGGAAATTCAAGCCAACCTTTTGTTTGATCGGTTGAAGCCTT
TGAAGATGTTAGAGGAGAATCTGAGCAGAAACCTATCAGAAATTAAACTGTTGATCAGCCAGGCCCGCAAACAAGCAGCTTCTATTAAAG
TCGCCGTGTCTGCAGACAGAGATTGCATCCGGGCCTACCAGCCTCAGATTTCCTCTACCAACTACAATACCTTAACACTAAATGTTAAGA
CACAGGAACCCGATAATCTTCTCTTCTACCTCGGTAGCAGCACCGCTTCTGATTTCCTTGCAGTGGAGATGCGGCGAGGGAGAGTGGCCT
TCCTGTGGGACCTGGGCTCCGGGTCCACACGCTTGGAGTTTCCAGACTTTCCCATTGATGACAACAGATGGCACAGTATCCATGTAGCCA
GATTTGGAAACATTGGTTCACTGAGTGTAAAGGAAATGAGCTCAAATCAAAAGTCACCAACAAAAACAAGTAAATCCCCTGGGACAGCTA
ATGTTCTGGATGTAAACAATTCAACACTCATGTTTGTTGGAGGTCTTGGAGGACAAATCAAGAAATCTCCTGCTGTGAAGGTTACTCATT
TTAAAGGCTGCTTGGGGGAGGCCTTCCTGAATGGAAAATCCATAGGCCTATGGAACTATATTGAAAGGGAAGGCAAGTGCCGTGGGTGCT
TCGGAAGCTCCCAGAATGAAGACCCTTCCTTCCATTTTGACGGGAGTGGGTACTCTGTCGTGGAGAAGTCACTTCCGGCTACCGTGACCC
AGATAATCATGCTTTTTAATACCTTTTCACCTAATGGACTTCTTCTCTACCTGGGTTCATACGGCACAAAAGACTTTTTATCCATCGAGC
TGTTTCGTGGCAGAGTGAAGGTTATGACTGACCTGGGTTCAGGACCCATTACCCTTTTGACAGACAGACGTTATAACAATGGAACCTGGT
ACAAAATTGCCTTCCAGCGAAACCGGAAGCAAGGAGTGCTAGCAGTTATCGATGCCTATAACACCAGTAATAAAGAAACCAAGCAGGGCG
AGACTCCGGGAGCATCTTCTGACCTCAACCGCCTAGACAAGGACCCGATTTATGTGGGTGGATTACCAAGGTCAAGAGTTGTAAGGAGAG
GTGTCACCACCAAAAGCTTTGTGGGCTGCATCAAGAACCTGGAAATATCCAGATCAACCTTTGACTTACTCAGAAATTCCTATGGAGTGA
GAAAAGGCTGTTTACTGGAGCCCATCCGGAGTGTTAGCTTCCTGAAAGGCGGCTACATTGAATTGCCACCCAAATCTTTGTCACCAGAAT
CAGAATGGCTGGTAACATTTGCCACCACGAACAGCAGTGGCATCATCCTGGCTGCCCTCGGCGGGGATGTGGAGAAGCGGGGTGATCGTG
AGGAAGCACACGTGCCCTTCTTTTCCGTCATGCTGATCGGAGGCAACATTGAGGTACATGTCAATCCTGGGGATGGGACAGGCCTGAGAA
AAGCTCTCCTGCACGCTCCCACGGGTACCTGCAGTGATGGACAAGCGCATTCCATCTCCTTGGTCAGGAATCGGAGAATTATCACTGTCC
AATTGGATGAGAACAATCCTGTGGAAATGAAGTTGGGCACATTAGTAGAAAGCAGGACGATAAATGTGTCCAATCTGTACGTCGGGGGAA
TTCCAGAGGGAGAGGGGACGTCACTGCTCACAATGAGAAGATCGTTCCATGGCTGTATCAAAAACCTGATCTTCAATTTGGAACTTTTGG
ATTTCAACAGTGCAGTTGGCCATGAGCAAGTCGACCTGGACACCTGCTGGCTGTCAGAAAGGCCTAAGCTGGCTCCCGATGCAGAGGACA
GCAAGCTCTTGCCAGAGCCCCGGGCTTTTCCAGAACAGTGTGTGGTGGATGCAGCTCTGGAGTACGTTCCCGGCGCTCACCAGTTTGGTC
TCACACAAAACAGCCATTTCATCTTGCCTTTTAATCAGTCGGCTGTCAGAAAGAAGCTCTCGGTTGAGCTAAGCATCCGCACGTTCGCCT
CCAGCGGCCTGATTTACTACATGGCTCATCAGAACCAAGCAGACTACGCTGTGCTCCAGCTGCACGGGGGCCGCCTCCACTTCATGTTTG
ACCTTGGCAAAGGCAGAACAAAGGTCTCTCACCCTGCACTGCTCAGTGATGGCAAGTGGCACACGGTCAAGACAGACTATGTTAAAAGAA
AAGGCTTCATAACTGTCGACGGCCGAGAGTCTCCCATGGTGACTGTGGTGGGAGATGGAACCATGCTGGATGTGGAGGGTTTGTTCTACC
TAGGAGGCCTGCCCTCCCAGTACCAGGCCAGGAAAATTGGAAATATCACCCACAGCATCCCTGCCTGCATTGGGGATGTGACGGTTAACA
GCAAACAGCTGGACAAGGACAGCCCGGTGTCTGCCTTCACGGTGAACAGGTGCTACGCAGTGGCCCAGGAAGGAACATACTTTGACGGAA
GCGGATATGCAGCTCTTGTCAAAGAGGGCTACAAAGTCCAGTCAGATGTGAACATCACACTGGAGTTTCGAACCTCCTCGCAGAATGGCG
TCCTCCTGGGGATCAGCACTGCCAAAGTGGATGCCATTGGACTAGAGCTTGTGGACGGCAAGGTCTTGTTCCATGTCAACAATGGTGCTG
GCAGGATAACAGCTGCATATGAGCCCAAAACCGCCACTGTGCTCTGTGATGGAAAATGGCACACTCTTCAAGCTAACAAAAGCAAACACC
GTATCACTCTGATTGTTGACGGGAACGCAGTTGGCGCTGAAAGTCCACACACCCAGTCTACCTCAGTGGACACCAACAATCCCATTTATG
TTGGTGGCTATCCTGCTGGTGTGAAGCAAAAATGCCTGCGCAGCCAGACCTCGTTCCGCGGGTGTTTGAGGAAGCTAGCTCTGATTAAGA
GCCCGCAGGTGCAGTCCTTTGACTTCAGCAGAGCGTTCGAACTGCACGGAGTTTTCCTTCATTCCTGTCCTGGGACCGAGTCCTGAACTT
CAAGCAGAATCCTCAGTTGGAATCATTGCTAATATTTTGAGGAGAAGTGTATGTGTGAATTAAGAATCTCTTCAGTTCATATTTCATTTC
CAACTCAGGTTAAGTGTTTCTGGGGAGAGATGTTGTGTTTACGTTACACTAAAACCACATGTGCAACAAATACCTCCATTAAATGGTCTA
AAATGTAAATTGAATTCCCTGGCTCTCTTTTTAAACGTATTTTTAAAAAAATCTTTATACACATTGAATGTTCTGTTGATTACTTGATAG

>5554_5554_1_APOC1-LAMA1_APOC1_chr19_45419584_ENST00000586638_LAMA1_chr18_7042250_ENST00000389658_length(amino acids)=2720AA_BP=30
MRLFLSLPVLVVVLSIVLEVEPFPGHGRAGVSPYEDEPCRPCNCDPVGSLSSVCIKDDLHSDLHNGKQPGQCPCKEGYTGEKCDRCQLGY
KDYPTCVSCGCNPVGSASDEPCTGPCVCKENVEGKACDRCKPGFYNLKEKNPRGCSECFCFGVSDVCSSLSWPVGQVNSMSGWLVTDLIS
PRKIPSQQDALGGRHQVSINNTAVMQRLAPKYYWAAPEAYLGNKLTAFGGFLKYTVSYDIPVETVDSNLMSHADVIIKGNGLTLSTQAEG
LSLQPYEEYLNVVRLVPENFQDFHSKRQIDRDQLMTVLANVTHLLIRANYNSAKMALYRLESVSLDIASSNAIDLVVAADVEHCECPQGY
TGTSCESCLSGYYRVDGILFGGICQPCECHGHAAECNVHGVCIACAHNTTGVHCEQCLPGFYGEPSRGTPGDCQPCACPLTIASNNFSPT
CHLNDGDEVVCDWCAPGYSGAWCERCADGYYGNPTVPGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGNTDGAHCERCADGFYGDAVT
AKNCRACECHVKGSHSAVCHLETGLCDCKPNVTGQQCDQCLHGYYGLDSGHGCRPCNCSVAGSVSDGCTDEGQCHCVPGVAGKRCDRCAH
GFYAYQDGSCTPCDCPHTQNTCDPETGECVCPPHTQGVKCEECEDGHWGYDAEVGCQACNCSLVGSTHHRCDVVTGHCQCKSKFGGRACD
QCSLGYRDFPDCVPCDCDLRGTSGDACNLEQGLCGCVEETGACPCKENVFGPQCNECREGTFALRADNPLGCSPCFCSGLSHLCSELEDY
VRTPVTLGSDQPLLRVVSQSNLRGTTEGVYYQAPDFLLDAATVRQHIRAEPFYWRLPQQFQGDQLMAYGGKLKYSVAFYSLDGVGTSNFE
PQVLIKGGRIRKQVIYMDAPAPENGVRQEQEVAMRENFWKYFNSVSEKPVTREDFMSVLSDIEYILIKASYGQGLQQSRISDISMEVGRK
AEKLHPEEEVASLLENCVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCDPNTGKCLNCGDNTAGDHCDVCT
SGYYGKVTGSASDCALCACPHSPPASFSPTCVLEGDHDFRCDACLLGYEGKHCERCSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCDRTS
GQCVCRLGASGLRCDECEPRHILMETDCVSCDDECVGVLLNDLDEIGDAVLSLNLTGIIPVPYGILSNLENTTKYLQESLLKENMQKDLG
KIKLEGVAEETDNLQKKLTRMLASTQKVNRATERIFKESQDLAIAIERLQMSITEIMEKTTLNQTLDEDFLLPNSTLQNMQQNGTSLLEI
MQIRDFTQLHQNATLELKAAEDLLSQIQENYQKPLEELEVLKEAASHVLSKHNNELKAAEALVREAEAKMQESNHLLLMVNANLREFSDK
KLHVQEEQNLTSELIVQGRGLIDAAAAQTDAVQDALEHLEDHQDKLLLWSAKIRHHIDDLVMHMSQRNAVDLVYRAEDHAAEFQRLADVL
YSGLENIRNVSLNATSAAYVHYNIQSLIEESEELARDAHRTVTETSLLSESLVSNGKAAVQRSSRFLKEGNNLSRKLPGIALELSELRNK
TNRFQENAVEITRQTNESLLILRAIPKGIRDKGAKTKELATSASQSAVSTLRDVAGLSQELLNTSASLSRVNTTLRETHQLLQDSTMATL
LAGRKVKDVEIQANLLFDRLKPLKMLEENLSRNLSEIKLLISQARKQAASIKVAVSADRDCIRAYQPQISSTNYNTLTLNVKTQEPDNLL
FYLGSSTASDFLAVEMRRGRVAFLWDLGSGSTRLEFPDFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNS
TLMFVGGLGGQIKKSPAVKVTHFKGCLGEAFLNGKSIGLWNYIEREGKCRGCFGSSQNEDPSFHFDGSGYSVVEKSLPATVTQIIMLFNT
FSPNGLLLYLGSYGTKDFLSIELFRGRVKVMTDLGSGPITLLTDRRYNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSD
LNRLDKDPIYVGGLPRSRVVRRGVTTKSFVGCIKNLEISRSTFDLLRNSYGVRKGCLLEPIRSVSFLKGGYIELPPKSLSPESEWLVTFA
TTNSSGIILAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSISLVRNRRIITVQLDENNPV
EMKLGTLVESRTINVSNLYVGGIPEGEGTSLLTMRRSFHGCIKNLIFNLELLDFNSAVGHEQVDLDTCWLSERPKLAPDAEDSKLLPEPR
AFPEQCVVDAALEYVPGAHQFGLTQNSHFILPFNQSAVRKKLSVELSIRTFASSGLIYYMAHQNQADYAVLQLHGGRLHFMFDLGKGRTK
VSHPALLSDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLPSQYQARKIGNITHSIPACIGDVTVNSKQLDKDS
PVSAFTVNRCYAVAQEGTYFDGSGYAALVKEGYKVQSDVNITLEFRTSSQNGVLLGISTAKVDAIGLELVDGKVLFHVNNGAGRITAAYE
PKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGAESPHTQSTSVDTNNPIYVGGYPAGVKQKCLRSQTSFRGCLRKLALIKSPQVQSFD

--------------------------------------------------------------
>5554_5554_2_APOC1-LAMA1_APOC1_chr19_45419584_ENST00000592885_LAMA1_chr18_7042250_ENST00000389658_length(transcript)=8660nt_BP=252nt
CTCCCAACCAAGCCCTCCAGCAAGGATTCAGAGTGCCCCTCCGGCCTCGCCATGAGGCTCTTCCTGTCGCTCCCGGTCCTGGTGGTGGTT
CTGTCGATCGTCTTGGAAGTAGAACCCTTCCCAGGGCACGGGAGAGCTGGGGTGTGTTTTTGGGTGGAGCCCTGGCAGATGGTCCAAGAT
GAACAGATTGAAAAAAAAACAAGTCCTGGAGAGGCTGACAACATCCCTCTGGTCACACAGCTAGATCTCAAGGTGTCTCCTTATGAGGAT
GAGCCTTGCCGCCCCTGTAATTGTGACCCTGTGGGGTCCCTCAGTTCTGTCTGTATTAAGGATGACCTCCATTCTGACTTACACAATGGG
AAGCAGCCAGGTCAGTGCCCATGTAAGGAAGGTTATACAGGAGAAAAATGTGATCGCTGCCAACTTGGCTATAAGGATTACCCGACCTGT
GTCTCCTGTGGGTGCAACCCAGTGGGCAGTGCCAGTGATGAGCCCTGCACAGGGCCCTGTGTTTGTAAGGAAAACGTTGAGGGGAAGGCC
TGTGATCGCTGCAAGCCAGGATTCTATAACTTGAAGGAAAAAAACCCCCGGGGCTGCTCCGAGTGCTTCTGCTTTGGCGTTTCTGATGTC
TGCAGCAGCCTCTCTTGGCCTGTTGGTCAGGTAAACAGTATGTCCGGGTGGCTGGTCACCGACTTGATCAGTCCCAGGAAGATCCCGTCT
CAGCAAGATGCACTAGGCGGGCGCCATCAGGTCAGCATCAACAACACCGCGGTCATGCAGAGACTGGCTCCCAAGTACTACTGGGCAGCC
CCCGAGGCCTACCTTGGAAATAAGCTGACTGCGTTTGGCGGATTCCTGAAATACACGGTGTCCTACGATATTCCGGTAGAGACGGTAGAC
AGTAACCTCATGTCGCATGCTGACGTCATCATTAAGGGAAACGGACTCACTTTAAGCACACAGGCTGAGGGTCTGTCATTGCAGCCTTAT
GAAGAGTACCTAAACGTGGTTAGACTTGTGCCTGAAAACTTCCAAGATTTTCACAGCAAAAGGCAGATTGATCGTGACCAGCTGATGACT
GTCCTTGCCAATGTGACACATCTTTTGATCAGAGCCAACTACAATTCTGCAAAAATGGCTCTTTACAGGTTGGAGTCCGTCTCTCTGGAC
ATAGCCAGCTCTAATGCCATCGACCTGGTGGTGGCCGCTGATGTGGAGCACTGTGAATGTCCGCAAGGCTACACAGGGACCTCCTGTGAG
TCGTGCCTCTCTGGCTATTACCGCGTGGATGGAATACTCTTTGGAGGAATTTGTCAACCCTGTGAATGCCACGGCCATGCAGCTGAGTGT
AATGTTCACGGCGTTTGCATTGCGTGTGCGCACAACACCACCGGCGTCCACTGTGAGCAGTGCTTGCCCGGCTTCTACGGGGAGCCTTCC
CGAGGGACACCTGGGGACTGCCAGCCCTGCGCCTGCCCTCTCACCATAGCCTCCAACAATTTCAGCCCCACCTGCCACCTCAATGATGGA
GATGAAGTGGTCTGTGACTGGTGTGCCCCGGGCTACTCAGGAGCTTGGTGTGAGAGATGTGCAGATGGTTACTATGGAAACCCAACAGTG
CCTGGCGAATCTTGTGTTCCCTGTGACTGCAGCGGCAACGTGGACCCCTCGGAGGCTGGTCACTGTGACTCAGTCACCGGGGAGTGCCTG
AAGTGCCTGGGGAACACAGATGGCGCCCACTGTGAAAGGTGTGCTGACGGGTTCTATGGGGACGCTGTGACAGCCAAGAACTGCCGCGCC
TGTGAATGCCATGTGAAAGGCTCCCATTCTGCCGTGTGCCATCTTGAGACCGGGCTCTGTGACTGCAAACCAAACGTGACTGGACAGCAG
TGTGACCAGTGCTTGCATGGCTATTATGGGCTGGACTCAGGCCATGGCTGCCGGCCCTGCAACTGCAGCGTGGCAGGCTCCGTGTCAGAT
GGCTGCACGGATGAAGGCCAGTGTCACTGTGTCCCAGGTGTGGCAGGGAAAAGGTGTGACAGGTGTGCCCATGGCTTCTACGCCTACCAG
GATGGTAGCTGTACACCCTGTGACTGCCCACACACTCAGAATACCTGCGACCCAGAAACTGGAGAGTGTGTCTGCCCCCCTCACACACAG
GGTGTGAAGTGTGAAGAATGTGAGGATGGGCACTGGGGCTACGATGCGGAGGTGGGGTGCCAGGCCTGCAATTGCAGTCTCGTGGGGTCG
ACTCATCATCGGTGCGATGTGGTCACCGGCCATTGCCAGTGCAAGTCAAAATTTGGTGGCCGGGCCTGCGATCAGTGTTCCTTGGGTTAC
AGAGACTTTCCCGACTGTGTTCCCTGTGACTGTGACCTGAGGGGGACGTCGGGGGACGCCTGCAACCTGGAGCAGGGTCTCTGCGGCTGT
GTGGAGGAAACCGGGGCCTGCCCTTGCAAGGAAAATGTCTTTGGTCCTCAGTGCAACGAATGTCGAGAGGGCACCTTCGCTCTCCGCGCA
GACAACCCCCTGGGCTGCAGCCCGTGCTTCTGCTCCGGGCTGTCCCACCTCTGCTCAGAGCTGGAGGACTACGTGAGGACCCCAGTAACG
CTGGGCTCCGATCAGCCTCTTCTGCGTGTGGTTTCTCAGAGTAACTTGAGGGGCACGACCGAGGGGGTTTACTACCAGGCCCCCGACTTC
CTGCTGGATGCCGCCACCGTCCGGCAGCACATCCGTGCAGAGCCGTTTTACTGGCGGCTGCCGCAGCAGTTCCAAGGAGACCAGCTCATG
GCCTATGGTGGCAAACTGAAGTACAGCGTGGCCTTCTATTCTTTGGATGGCGTCGGCACCTCCAATTTTGAGCCTCAAGTTCTCATCAAA
GGTGGTCGGATCAGAAAGCAAGTCATTTACATGGATGCACCAGCCCCAGAGAATGGAGTGAGACAGGAACAAGAAGTAGCAATGAGAGAG
AATTTTTGGAAATATTTTAACTCTGTTTCTGAAAAACCTGTCACGCGAGAGGATTTTATGTCTGTCCTCAGCGATATTGAGTACATCCTC
ATCAAGGCATCGTATGGTCAAGGATTACAGCAGAGCAGAATCTCAGACATTTCAATGGAGGTTGGCAGAAAGGCTGAAAAGCTGCACCCA
GAAGAAGAGGTTGCATCTCTTTTAGAGAATTGTGTCTGTCCTCCTGGCACTGTGGGATTCTCATGTCAGGACTGCGCCCCTGGGTACCAC
AGAGGGAAGCTCCCAGCAGGGAGTGACAGGGGACCACGCCCTCTGGTTGCTCCTTGTGTTCCCTGCAGTTGCAACAACCACAGTGACACC
TGTGACCCCAACACCGGGAAGTGTCTGAACTGTGGCGATAACACAGCAGGTGACCATTGTGATGTGTGTACTTCTGGCTACTACGGGAAG
GTGACTGGCTCAGCAAGTGACTGTGCTCTGTGTGCCTGTCCTCACAGCCCTCCTGCCAGTTTTAGTCCCACTTGTGTCTTGGAAGGGGAC
CACGATTTCCGTTGTGACGCCTGTCTCCTGGGCTATGAAGGAAAACACTGTGAAAGGTGCTCCTCAAGCTATTATGGGAACCCTCAAACA
CCAGGTGGCAGTTGCCAGAAGTGTGACTGCAACCCGCACGGCTCTGTCCACGGTGACTGTGACCGCACATCTGGGCAGTGCGTTTGCAGG
CTGGGGGCCTCGGGGCTCCGGTGCGATGAGTGTGAACCGAGGCACATTCTGATGGAAACAGATTGTGTTTCCTGTGATGATGAGTGTGTA
GGTGTGCTGCTGAATGACTTGGATGAGATTGGTGATGCCGTTCTTTCTCTGAACCTCACTGGCATTATCCCTGTCCCATATGGAATTTTG
TCAAACCTGGAAAATACAACTAAATATCTCCAGGAATCTTTATTAAAAGAAAATATGCAAAAGGACCTGGGAAAAATTAAGCTTGAAGGT
GTTGCAGAAGAAACGGACAACCTGCAAAAGAAGCTCACTAGGATGTTAGCGAGTACCCAAAAGGTGAATAGGGCAACTGAGAGAATCTTC
AAGGAGAGTCAAGACCTGGCCATAGCCATTGAGAGGCTGCAGATGAGCATCACAGAAATTATGGAAAAGACAACTTTAAATCAGACTTTG
GATGAAGATTTCCTACTACCCAATTCTACTCTTCAGAACATGCAACAGAATGGTACATCTTTGCTAGAAATCATGCAGATAAGAGACTTC
ACACAGTTGCACCAAAATGCCACCCTTGAACTCAAGGCTGCTGAAGATTTATTGTCACAAATTCAGGAAAATTACCAGAAGCCGCTGGAA
GAATTGGAGGTATTGAAAGAAGCAGCAAGCCACGTCCTTTCAAAGCACAACAATGAACTAAAGGCGGCTGAGGCGCTCGTGAGGGAAGCT
GAGGCAAAGATGCAGGAAAGCAACCACCTGCTGCTCATGGTCAATGCTAATCTGAGAGAATTCAGTGATAAAAAGCTGCATGTTCAAGAA
GAACAAAATCTGACCTCAGAGCTCATTGTCCAAGGAAGAGGATTGATAGATGCTGCTGCTGCACAAACAGATGCTGTACAAGATGCTCTA
GAGCACTTAGAGGATCACCAGGATAAGCTACTTTTATGGTCTGCCAAAATCAGGCACCACATAGATGACCTGGTCATGCACATGTCCCAA
AGGAACGCAGTCGACCTGGTCTACAGAGCTGAGGACCATGCCGCTGAGTTCCAGAGACTAGCAGATGTTCTGTACAGTGGCCTTGAAAAC
ATCAGAAATGTGTCCCTGAATGCCACCAGTGCAGCCTATGTCCATTACAACATCCAGAGCCTGATTGAAGAATCGGAGGAACTGGCCAGA
GATGCTCACAGGACTGTGACTGAGACGAGCCTGCTCTCAGAATCCCTTGTTTCTAACGGGAAAGCGGCCGTGCAGCGCAGCTCCAGATTT
CTAAAAGAAGGCAACAACCTCAGCAGGAAGCTTCCAGGTATTGCATTGGAACTGAGTGAATTGAGAAATAAGACAAACAGATTTCAAGAG
AATGCTGTTGAAATTACCAGGCAAACCAATGAATCACTCTTGATACTTAGAGCAATTCCTAAAGGTATAAGAGACAAGGGAGCCAAAACC
AAAGAGCTGGCCACGTCTGCAAGCCAGAGCGCGGTGAGCACGCTGAGGGACGTGGCGGGGCTGAGCCAGGAGCTGCTGAACACATCTGCC
AGCCTGTCCAGGGTCAACACCACATTACGAGAGACACACCAGCTTCTGCAGGACTCCACCATGGCCACTCTGTTGGCTGGAAGAAAAGTC
AAAGACGTGGAAATTCAAGCCAACCTTTTGTTTGATCGGTTGAAGCCTTTGAAGATGTTAGAGGAGAATCTGAGCAGAAACCTATCAGAA
ATTAAACTGTTGATCAGCCAGGCCCGCAAACAAGCAGCTTCTATTAAAGTCGCCGTGTCTGCAGACAGAGATTGCATCCGGGCCTACCAG
CCTCAGATTTCCTCTACCAACTACAATACCTTAACACTAAATGTTAAGACACAGGAACCCGATAATCTTCTCTTCTACCTCGGTAGCAGC
ACCGCTTCTGATTTCCTTGCAGTGGAGATGCGGCGAGGGAGAGTGGCCTTCCTGTGGGACCTGGGCTCCGGGTCCACACGCTTGGAGTTT
CCAGACTTTCCCATTGATGACAACAGATGGCACAGTATCCATGTAGCCAGATTTGGAAACATTGGTTCACTGAGTGTAAAGGAAATGAGC
TCAAATCAAAAGTCACCAACAAAAACAAGTAAATCCCCTGGGACAGCTAATGTTCTGGATGTAAACAATTCAACACTCATGTTTGTTGGA
GGTCTTGGAGGACAAATCAAGAAATCTCCTGCTGTGAAGGTTACTCATTTTAAAGGCTGCTTGGGGGAGGCCTTCCTGAATGGAAAATCC
ATAGGCCTATGGAACTATATTGAAAGGGAAGGCAAGTGCCGTGGGTGCTTCGGAAGCTCCCAGAATGAAGACCCTTCCTTCCATTTTGAC
GGGAGTGGGTACTCTGTCGTGGAGAAGTCACTTCCGGCTACCGTGACCCAGATAATCATGCTTTTTAATACCTTTTCACCTAATGGACTT
CTTCTCTACCTGGGTTCATACGGCACAAAAGACTTTTTATCCATCGAGCTGTTTCGTGGCAGAGTGAAGGTTATGACTGACCTGGGTTCA
GGACCCATTACCCTTTTGACAGACAGACGTTATAACAATGGAACCTGGTACAAAATTGCCTTCCAGCGAAACCGGAAGCAAGGAGTGCTA
GCAGTTATCGATGCCTATAACACCAGTAATAAAGAAACCAAGCAGGGCGAGACTCCGGGAGCATCTTCTGACCTCAACCGCCTAGACAAG
GACCCGATTTATGTGGGTGGATTACCAAGGTCAAGAGTTGTAAGGAGAGGTGTCACCACCAAAAGCTTTGTGGGCTGCATCAAGAACCTG
GAAATATCCAGATCAACCTTTGACTTACTCAGAAATTCCTATGGAGTGAGAAAAGGCTGTTTACTGGAGCCCATCCGGAGTGTTAGCTTC
CTGAAAGGCGGCTACATTGAATTGCCACCCAAATCTTTGTCACCAGAATCAGAATGGCTGGTAACATTTGCCACCACGAACAGCAGTGGC
ATCATCCTGGCTGCCCTCGGCGGGGATGTGGAGAAGCGGGGTGATCGTGAGGAAGCACACGTGCCCTTCTTTTCCGTCATGCTGATCGGA
GGCAACATTGAGGTACATGTCAATCCTGGGGATGGGACAGGCCTGAGAAAAGCTCTCCTGCACGCTCCCACGGGTACCTGCAGTGATGGA
CAAGCGCATTCCATCTCCTTGGTCAGGAATCGGAGAATTATCACTGTCCAATTGGATGAGAACAATCCTGTGGAAATGAAGTTGGGCACA
TTAGTAGAAAGCAGGACGATAAATGTGTCCAATCTGTACGTCGGGGGAATTCCAGAGGGAGAGGGGACGTCACTGCTCACAATGAGAAGA
TCGTTCCATGGCTGTATCAAAAACCTGATCTTCAATTTGGAACTTTTGGATTTCAACAGTGCAGTTGGCCATGAGCAAGTCGACCTGGAC
ACCTGCTGGCTGTCAGAAAGGCCTAAGCTGGCTCCCGATGCAGAGGACAGCAAGCTCTTGCCAGAGCCCCGGGCTTTTCCAGAACAGTGT
GTGGTGGATGCAGCTCTGGAGTACGTTCCCGGCGCTCACCAGTTTGGTCTCACACAAAACAGCCATTTCATCTTGCCTTTTAATCAGTCG
GCTGTCAGAAAGAAGCTCTCGGTTGAGCTAAGCATCCGCACGTTCGCCTCCAGCGGCCTGATTTACTACATGGCTCATCAGAACCAAGCA
GACTACGCTGTGCTCCAGCTGCACGGGGGCCGCCTCCACTTCATGTTTGACCTTGGCAAAGGCAGAACAAAGGTCTCTCACCCTGCACTG
CTCAGTGATGGCAAGTGGCACACGGTCAAGACAGACTATGTTAAAAGAAAAGGCTTCATAACTGTCGACGGCCGAGAGTCTCCCATGGTG
ACTGTGGTGGGAGATGGAACCATGCTGGATGTGGAGGGTTTGTTCTACCTAGGAGGCCTGCCCTCCCAGTACCAGGCCAGGAAAATTGGA
AATATCACCCACAGCATCCCTGCCTGCATTGGGGATGTGACGGTTAACAGCAAACAGCTGGACAAGGACAGCCCGGTGTCTGCCTTCACG
GTGAACAGGTGCTACGCAGTGGCCCAGGAAGGAACATACTTTGACGGAAGCGGATATGCAGCTCTTGTCAAAGAGGGCTACAAAGTCCAG
TCAGATGTGAACATCACACTGGAGTTTCGAACCTCCTCGCAGAATGGCGTCCTCCTGGGGATCAGCACTGCCAAAGTGGATGCCATTGGA
CTAGAGCTTGTGGACGGCAAGGTCTTGTTCCATGTCAACAATGGTGCTGGCAGGATAACAGCTGCATATGAGCCCAAAACCGCCACTGTG
CTCTGTGATGGAAAATGGCACACTCTTCAAGCTAACAAAAGCAAACACCGTATCACTCTGATTGTTGACGGGAACGCAGTTGGCGCTGAA
AGTCCACACACCCAGTCTACCTCAGTGGACACCAACAATCCCATTTATGTTGGTGGCTATCCTGCTGGTGTGAAGCAAAAATGCCTGCGC
AGCCAGACCTCGTTCCGCGGGTGTTTGAGGAAGCTAGCTCTGATTAAGAGCCCGCAGGTGCAGTCCTTTGACTTCAGCAGAGCGTTCGAA
CTGCACGGAGTTTTCCTTCATTCCTGTCCTGGGACCGAGTCCTGAACTTCAAGCAGAATCCTCAGTTGGAATCATTGCTAATATTTTGAG
GAGAAGTGTATGTGTGAATTAAGAATCTCTTCAGTTCATATTTCATTTCCAACTCAGGTTAAGTGTTTCTGGGGAGAGATGTTGTGTTTA
CGTTACACTAAAACCACATGTGCAACAAATACCTCCATTAAATGGTCTAAAATGTAAATTGAATTCCCTGGCTCTCTTTTTAAACGTATT
TTTAAAAAAATCTTTATACACATTGAATGTTCTGTTGATTACTTGATAGTATTTTATGTTTTTCATTTTGAGCTTTTTAAAAAAGTATCA

>5554_5554_2_APOC1-LAMA1_APOC1_chr19_45419584_ENST00000592885_LAMA1_chr18_7042250_ENST00000389658_length(amino acids)=2757AA_BP=67
MRLFLSLPVLVVVLSIVLEVEPFPGHGRAGVCFWVEPWQMVQDEQIEKKTSPGEADNIPLVTQLDLKVSPYEDEPCRPCNCDPVGSLSSV
CIKDDLHSDLHNGKQPGQCPCKEGYTGEKCDRCQLGYKDYPTCVSCGCNPVGSASDEPCTGPCVCKENVEGKACDRCKPGFYNLKEKNPR
GCSECFCFGVSDVCSSLSWPVGQVNSMSGWLVTDLISPRKIPSQQDALGGRHQVSINNTAVMQRLAPKYYWAAPEAYLGNKLTAFGGFLK
YTVSYDIPVETVDSNLMSHADVIIKGNGLTLSTQAEGLSLQPYEEYLNVVRLVPENFQDFHSKRQIDRDQLMTVLANVTHLLIRANYNSA
KMALYRLESVSLDIASSNAIDLVVAADVEHCECPQGYTGTSCESCLSGYYRVDGILFGGICQPCECHGHAAECNVHGVCIACAHNTTGVH
CEQCLPGFYGEPSRGTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPGYSGAWCERCADGYYGNPTVPGESCVPCDCSGNVDPS
EAGHCDSVTGECLKCLGNTDGAHCERCADGFYGDAVTAKNCRACECHVKGSHSAVCHLETGLCDCKPNVTGQQCDQCLHGYYGLDSGHGC
RPCNCSVAGSVSDGCTDEGQCHCVPGVAGKRCDRCAHGFYAYQDGSCTPCDCPHTQNTCDPETGECVCPPHTQGVKCEECEDGHWGYDAE
VGCQACNCSLVGSTHHRCDVVTGHCQCKSKFGGRACDQCSLGYRDFPDCVPCDCDLRGTSGDACNLEQGLCGCVEETGACPCKENVFGPQ
CNECREGTFALRADNPLGCSPCFCSGLSHLCSELEDYVRTPVTLGSDQPLLRVVSQSNLRGTTEGVYYQAPDFLLDAATVRQHIRAEPFY
WRLPQQFQGDQLMAYGGKLKYSVAFYSLDGVGTSNFEPQVLIKGGRIRKQVIYMDAPAPENGVRQEQEVAMRENFWKYFNSVSEKPVTRE
DFMSVLSDIEYILIKASYGQGLQQSRISDISMEVGRKAEKLHPEEEVASLLENCVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVA
PCVPCSCNNHSDTCDPNTGKCLNCGDNTAGDHCDVCTSGYYGKVTGSASDCALCACPHSPPASFSPTCVLEGDHDFRCDACLLGYEGKHC
ERCSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCDRTSGQCVCRLGASGLRCDECEPRHILMETDCVSCDDECVGVLLNDLDEIGDAVLSL
NLTGIIPVPYGILSNLENTTKYLQESLLKENMQKDLGKIKLEGVAEETDNLQKKLTRMLASTQKVNRATERIFKESQDLAIAIERLQMSI
TEIMEKTTLNQTLDEDFLLPNSTLQNMQQNGTSLLEIMQIRDFTQLHQNATLELKAAEDLLSQIQENYQKPLEELEVLKEAASHVLSKHN
NELKAAEALVREAEAKMQESNHLLLMVNANLREFSDKKLHVQEEQNLTSELIVQGRGLIDAAAAQTDAVQDALEHLEDHQDKLLLWSAKI
RHHIDDLVMHMSQRNAVDLVYRAEDHAAEFQRLADVLYSGLENIRNVSLNATSAAYVHYNIQSLIEESEELARDAHRTVTETSLLSESLV
SNGKAAVQRSSRFLKEGNNLSRKLPGIALELSELRNKTNRFQENAVEITRQTNESLLILRAIPKGIRDKGAKTKELATSASQSAVSTLRD
VAGLSQELLNTSASLSRVNTTLRETHQLLQDSTMATLLAGRKVKDVEIQANLLFDRLKPLKMLEENLSRNLSEIKLLISQARKQAASIKV
AVSADRDCIRAYQPQISSTNYNTLTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRVAFLWDLGSGSTRLEFPDFPIDDNRWHSIHVAR
FGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTLMFVGGLGGQIKKSPAVKVTHFKGCLGEAFLNGKSIGLWNYIEREGKCRGCF
GSSQNEDPSFHFDGSGYSVVEKSLPATVTQIIMLFNTFSPNGLLLYLGSYGTKDFLSIELFRGRVKVMTDLGSGPITLLTDRRYNNGTWY
KIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPRSRVVRRGVTTKSFVGCIKNLEISRSTFDLLRNSYGVR
KGCLLEPIRSVSFLKGGYIELPPKSLSPESEWLVTFATTNSSGIILAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRK
ALLHAPTGTCSDGQAHSISLVRNRRIITVQLDENNPVEMKLGTLVESRTINVSNLYVGGIPEGEGTSLLTMRRSFHGCIKNLIFNLELLD
FNSAVGHEQVDLDTCWLSERPKLAPDAEDSKLLPEPRAFPEQCVVDAALEYVPGAHQFGLTQNSHFILPFNQSAVRKKLSVELSIRTFAS
SGLIYYMAHQNQADYAVLQLHGGRLHFMFDLGKGRTKVSHPALLSDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYL
GGLPSQYQARKIGNITHSIPACIGDVTVNSKQLDKDSPVSAFTVNRCYAVAQEGTYFDGSGYAALVKEGYKVQSDVNITLEFRTSSQNGV
LLGISTAKVDAIGLELVDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGAESPHTQSTSVDTNNPIYV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for APOC1-LAMA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APOC1-LAMA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APOC1-LAMA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPOC1C0002395Alzheimer's Disease2CTD_human
HgeneAPOC1C0011265Presenile dementia2CTD_human
HgeneAPOC1C0276496Familial Alzheimer Disease (FAD)2CTD_human
HgeneAPOC1C0494463Alzheimer Disease, Late Onset2CTD_human
HgeneAPOC1C0546126Acute Confusional Senile Dementia2CTD_human
HgeneAPOC1C0750900Alzheimer's Disease, Focal Onset2CTD_human
HgeneAPOC1C0750901Alzheimer Disease, Early Onset2CTD_human
HgeneAPOC1C0018801Heart failure1CTD_human
HgeneAPOC1C0018802Congestive heart failure1CTD_human
HgeneAPOC1C0023212Left-Sided Heart Failure1CTD_human
HgeneAPOC1C0235527Heart Failure, Right-Sided1CTD_human
HgeneAPOC1C1959583Myocardial Failure1CTD_human
HgeneAPOC1C1961112Heart Decompensation1CTD_human
TgeneC4014821Cerebellar ataxia, intellectual disability, oculomotor apraxia, cerebellar cysts syndrome2GENOMICS_ENGLAND;ORPHANET
TgeneC0009402Colorectal Carcinoma1CTD_human
TgeneC0009404Colorectal Neoplasms1CTD_human
TgeneC0020796Profound Mental Retardation1CTD_human
TgeneC0025363Mental Retardation, Psychosocial1CTD_human
TgeneC0036341Schizophrenia1CTD_human
TgeneC0400966Non-alcoholic Fatty Liver Disease1CTD_human
TgeneC0917816Mental deficiency1CTD_human
TgeneC3241937Nonalcoholic Steatohepatitis1CTD_human
TgeneC3714756Intellectual Disability1CTD_human